1141:
1100:
4582:
450:
272:
29:
1305:. These DNA methyltransferases can also methylate CpG sites within the coding regions of genes, where such methylation can increase gene transcription. Work with DNMT3a1 showed it preferentially localized to CpG islands bivalently marked by H3K4me3 (a transcription promoting mark) and H3K27me3 (a transcription repressive mark), coinciding with the
1206:
di-nucleotides in the mammalian genome. The recognition motif for the human enzyme involves only three of the bases in the CpG dinucleotide pair: a C on one strand and CpG on the other. This relaxed substrate specificity requirement allows it to methylate unusual structures like DNA slippage
1207:
intermediates at de novo rates that equal its maintenance rate. Like other DNA cytosine-5 methyltransferases the human enzyme recognizes flipped out cytosines in double stranded DNA and operates by the nucleophilic attack mechanism. In human cancer cells DNMT1 is responsible for both
1273:
transfer RNA and does not methylate DNA. The name for this methyltransferase has been changed from DNMT2 to TRDMT1 (tRNA aspartic acid methyltransferase 1) to better reflect its biological function. TRDMT1 is the first RNA cytosine methyltransferase to be identified in human cells.
1037:
Highly conserved DNA methyltransferases of the m4C, m5C, and m6A types have been reported, which appear as promising targets for the development of novel epigenetic inhibitors to fight bacterial virulence, antibiotic resistance, among other biomedical applications.
906:
Among the m6A methyltransferases (N-6 adenine-specific DNA methylase) there is a group of orphan MTases that do not participate in the bacterial restriction/methylation system. These enzymes have a regulatory role in gene expression and cell cycle regulation.
699:
m6A and m4C methyltransferases are found primarily in prokaryotes (although recent evidence has suggested that m6A is abundant in eukaryotes). m5C methyltransferases are found in some lower eukaryotes, in most higher plants, and in animals beginning with the
841:(CM) arrangements. According to this classification, N6-MTases that have a DPPY motif (CM II) occurring after the FxGxG motif (CM I) are designated D12 class N6-adenine MTases. The type I restriction and modification system is composed of three
1599:
Narva KE, Van Etten JL, Slatko BE, Benner JS (December 1988). "The amino acid sequence of the eukaryotic DNA methyltransferase, M.CviBIII, has regions of similarity with the prokaryotic isoschizomer M.TaqI and other DNA methyltransferases".
1154:
Manzo et al. observed differences in genomic binding of DNMT3a1, DNMT3a2 and DNMT3b. They found 3,970 regions exclusively enriched for DNMT3a1, 3,838 exclusively enriched for DNMT3a2 and 3,432 exclusively enriched for DNMT3b.
1293:
at the same rate. The architecture of DNMT3 enzymes is similar to that of DNMT1, with a regulatory region attached to a catalytic domain. There are at least five members of the DNMT3 family: DNMT3a1, DNMT3a2, 3b, 3c and 3L.
1075:
add methylation to DNA when one strand is already methylated. These work throughout the life of the organism to maintain the methylation pattern that had been established by the de novo methyltransferases.
1117:
proteins in a tightly assembled core region plus up to 30% of each histone remaining in a loosely organized tail (only one tail of each pair is shown). DNA is wrapped around the histone core proteins in
1336:
protein (HP1) and methyl-CpG-binding protein (MeCBP), among a number of other factors. They can also interact with DNMT1, which might be a co-operative event during DNA methylation. DNMT3a prefers
1049:
methyltransferases recognize something in the DNA that allows them to newly methylate cytosines. These are expressed mainly in early embryo development and they set up the pattern of methylation.
1317:, found that the DNA methylation changes caused by DNMT3a2 predominantly occur in intergenic and intronic regions. These intergenic and intronic DNA methylations were thought to likely regulate
1122:. The lysines (K) are designated with a number showing their position as, for instance (K4), indicating lysine as the 4th amino acid from the amino (N) end of the tail in the histone protein.
888:. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance methyltransferase, modifying the DNA so that both strands become
1269:
Although this enzyme has strong sequence similarities with 5-methylcytosine methyltransferases of both prokaryotes and eukaryotes, in 2006, the enzyme was shown to methylate position 38 in
2413:
Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, HĂ©rault Y, et al. (November 2016). "The DNA methyltransferase DNMT3C protects male germ cells from transposon activity".
2722:
Ting AH, Jair KW, Schuebel KE, Baylin SB (January 2006). "Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation".
1397:
expression of genes normally not expressed by the maternal allele. DNMT3L interacts with DNMT3a and DNMT3b and co-localized in the nucleus. Though DNMT3L appears incapable of
1261:
were viable and contained a small percentage of methylated DNA and methyltransferase activity. Mouse embryos homozygous for a deletion in Dnmt1 die at 10–11 days gestation.
2043:
Lauster R, Trautner TA, Noyer-Weidner M (March 1989). "Cytosine-specific type II DNA methyltransferases. A conserved enzyme core with variable target-recognizing domains".
1837:
Chahar S, Elsawy H, Ragozin S, Jeltsch A (January 2010). "Changing the DNA recognition specificity of the EcoDam DNA-(adenine-N6)-methyltransferase by directed evolution".
1471:
guadecitabine, an experimental drug under development by Astex
Pharmaceuticals and Otsuka Pharmaceutical. It failed to meet primary endpoints in a 2018 Phase III AML trial.
2593:
Kho MR, Baker DJ, Laayoun A, Smith SS (January 1998). "Stalling of human DNA (cytosine-5) methyltransferase at single-strand conformers from a site of dynamic mutation".
574:
408:
230:
133:
1675:
Timinskas A, Butkus V, Janulaitis A (May 1995). "Sequence motifs characteristic for DNA and DNA methyltransferases. Classification of all DNA methyltransferases".
4081:
1219:
long. The first 1,100 amino acids constitute the regulatory domain of the enzyme, and the remaining residues constitute the catalytic domain. These are joined by
2113:
Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ (July 1993). "Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine".
1872:
Maier JA, Albu RF, Jurkowski TP, Jeltsch A (December 2015). "Investigation of the C-terminal domain of the bacterial DNA-(adenine N6)-methyltransferase CcrM".
818:
binding sites, and comprises a central 9-stranded beta-sheet, surrounded by 5 helices; and a C-terminal DNA recognition domain, which is formed by 4 small
3224:
3912:
2341:"A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation"
4113:
1158:
The DNMT enzymes are not only regulated in their methylating locations on the genome by where they bind to DNA, but they are also regulated by the
4171:
1177:
methylation. For example, they indicated that H3K4me3 appears to block DNA methylation while H3K9me3 plays a role in promoting DNA methylation.
3358:
1343:
to CpA, CpT, and CpC methylation, though there appears to be some sequence preference of methylation for DNMT3a and DNMT3b. DNMT3a methylates
4067:
2687:
Jair KW, Bachman KE, Suzuki H, Ting AH, Rhee I, Yen RW, et al. (January 2006). "De novo CpG island methylation in human cancer cells".
1909:"Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis"
3968:
1354:. DNMT3a2 is induced to express in neurons, for instance, by new neuronal activity. This may be of importance in establishing long-term
4131:
4037:
3038:
Oliveira AM, Hemstedt TJ, Bading H (July 2012). "Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities".
1517:"Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification"
1183:
is a protein closely related to DNMT3a and DNMT3b in structure and critical for DNA methylation, but appears to be inactive on its own.
4232:
2380:
2306:
1712:"Three-dimensional structure of the adenine-specific DNA methyltransferase M.Taq I in complex with the cofactor S-adenosylmethionine"
1564:
Loenen WA, Daniel AS, Braymer HD, Murray NE (November 1987). "Organization and sequence of the hsd genes of
Escherichia coli K-12".
884:
but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target
4256:
4011:
1761:
Kelleher JE, Daniel AS, Murray NE (September 1991). "Mutations that confer de novo activity upon a maintenance methyltransferase".
3934:
3457:
2855:
4242:
3958:
2757:
Li E, Bestor TH, Jaenisch R (June 1992). "Targeted mutation of the DNA methyltransferase gene results in embryonic lethality".
1496:
3905:
3603:
1194:
is the most abundant DNA methyltransferase in mammalian cells, and considered to be the key maintenance methyltransferase in
1170:
around which the genomic DNA is wrapped (see
Figures). Rose and Klose reviewed the relationship between DNA methylation and
522:
344:
594:
428:
250:
153:
4196:
4268:
3988:
3984:
3835:
921:
865:
974:
m5C methyltransferases (C-5 cytosine-specific DNA methylase) (C5 Mtase) are enzymes that specifically methylate the C-5
4301:
3267:
1370:. Bayraktar and Kreutz found that DNMT inhibitors, applied in the brain, prevented long-term memories from forming.
4152:
3898:
2573:
2388:
2314:
4227:
4108:
3807:
1350:
The expression of DNMT3a2 differs from DNMT3a1 and DNMT3b because DNMT3a2 expression occurs in the pattern of an
1159:
1131:
1096:. Recently, another enzyme DNMT3c has been discovered specifically expressed in the male germline in the mouse.
1014:
are a component of restriction-modification systems and serve as valuable tools for the manipulation of DNA. The
719:
4217:
4212:
4136:
4016:
3860:
3369:
3802:
1956:
PĂłsfai J, Bhagwat AS, Roberts RJ (December 1988). "Sequence motifs specific for cytosine methyltransferases".
582:
416:
238:
141:
4457:
3993:
3953:
3855:
2932:
Karaca KG, Kupke J, Brito DV, Zeuch B, Thome C, Weichenhan D, Lutsik P, Plass C, Oliveira AM (January 2020).
2158:"Conserved DNA Methyltransferases: A Window into Fundamental Mechanisms of Epigenetic Regulation in Bacteria"
3823:
3797:
4222:
4062:
3285:
Pradhan S, Esteve PO (October 2003). "Mammalian DNA (cytosine-5) methyltransferases and their expression".
1461:
4237:
3450:
1084:
At least four differently active DNA methyltransferases have been identified in mammals. They are named
658:
MTases can be divided into three different groups on the basis of the chemical reactions they catalyze:
4572:
3483:
1302:
578:
412:
234:
137:
1425:
4558:
4545:
4532:
4519:
4506:
4493:
4480:
4442:
4047:
3963:
3680:
3616:
3586:
3564:
1710:
Labahn J, Granzin J, Schluckebier G, Robinson DP, Jack WE, Schildkraut I, Saenger W (November 1994).
535:
364:
357:
2469:"Isoform-specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands"
369:
4452:
4406:
4349:
4100:
3925:
3474:
3466:
3373:
3132:"The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders"
2630:"Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation"
1444:
1402:
1140:
1099:
831:
690:
678:
666:
4354:
3781:
3470:
1635:
Lauster R (March 1989). "Evolution of type II DNA methyltransferases. A gene duplication model".
1031:
835:
815:
3890:
4157:
3690:
3443:
2991:"Comprehensive analysis of regulation of DNA methyltransferase isoforms in human breast tumors"
1907:
Oliveira PH, Ribis JW, Garrett EM, Trzilova D, Kim A, Sekulovic O, et al. (January 2020).
1448:
2801:
4375:
4294:
3874:
3869:
3737:
3327:
3252:
Biological implications of the mechanism of action of human DNA (cytosine-5)methyltransferase
1419:
642:
2565:
2392:
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3685:
3651:
3545:
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2813:
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2422:
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1351:
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869:
561:
395:
217:
120:
3254:. Progress in Nucleic Acid Research and Molecular Biology. Vol. 49. pp. 65–111.
2800:
Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, et al. (January 2006).
8:
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969:
881:
861:
796:
788:
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723:
3435:
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2817:
2645:
2426:
1994:
Kumar S, Cheng X, Klimasauskas S, Mi S, Posfai J, Roberts RJ, Wilson GG (January 1994).
641:
serves a wide variety of biological functions. All the known DNA methyltransferases use
4344:
3523:
3339:
3206:
3158:
3131:
3107:
3082:
3063:
3015:
2990:
2966:
2933:
2906:
2882:"Gene body methylation can alter gene expression and is a therapeutic target in cancer"
2881:
2837:
2782:
2542:
2518:"Understanding the relationship between DNA methylation and histone lysine methylation"
2517:
2493:
2468:
2446:
2283:
2258:
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2182:
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2138:
1933:
1908:
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1516:
1390:
1378:
953:
781:
755:
747:
739:
3298:
3259:
2020:
1995:
33:
crystal structure of type i restriction enzyme ecoki m protein (ec 2.1.1.72) (m.ecoki)
4602:
4123:
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3842:
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3331:
3302:
3273:
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1613:
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1546:
1481:
1367:
1251:
1058:
991:
850:
687:
675:
569:
527:
403:
349:
225:
128:
3343:
3210:
3067:
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2786:
2450:
2240:
2142:
478:
300:
191:
57:
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4385:
4359:
4287:
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3002:
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2218:
2177:
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2122:
2087:
2052:
2015:
2007:
1965:
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1809:
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116:
2735:
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Manzo M, Wirz J, Ambrosi C, Villaseñor R, Roschitzki B, Baubec T (December 2017).
491:
313:
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2533:
1885:
1486:
1333:
999:
873:
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807:
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82:
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specificity as their corresponding restriction enzymes. These enzymes contain a
4586:
4475:
4416:
3838:
3826:
3776:
3006:
2957:
2634:
Proceedings of the
National Academy of Sciences of the United States of America
1716:
Proceedings of the
National Academy of Sciences of the United States of America
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1429:
1374:
1326:
1023:
896:
838:
827:
3098:
2897:
2173:
1924:
1850:
707:
The m6A methyltransferases (N-6 adenine-specific DNA methylase) (A-Mtase) are
4596:
4380:
4339:
4085:
3540:
3148:
1728:
1491:
1386:
1270:
965:
908:
893:
777:
761:
758:
2825:
2654:
2484:
2434:
1814:
1053:
methyltransferases are also active when a signal-responsive cell, such as a
4329:
4003:
3335:
3306:
3225:"EC Approves Marketing Authorization Of DACOGEN For Acute Myeloid Leukemia"
3202:
3167:
3116:
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2743:
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2551:
2502:
2442:
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2357:
2340:
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2232:
2223:
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2191:
1942:
1893:
1858:
1823:
1550:
1532:
1243:
877:
842:
630:
607:
3277:
2778:
2673:
2614:
2274:
2134:
2099:
2064:
2029:
1977:
1782:
1747:
1696:
1656:
1621:
1585:
531:
353:
4553:
4488:
4324:
3921:
3727:
3695:
3598:
2934:"Neuronal ensemble-specific DNA methylation strengthens engram stability"
2880:
Yang X, Han H, De
Carvalho DD, Lay FD, Jones PA, Liang G (October 2014).
2011:
1440:
1398:
1363:
1340:
1199:
1127:
1123:
1066:
949:
919:
are well characterized members of these family. More recently, CamA from
889:
854:
823:
735:
701:
681:
1289:
methyltransferases that could methylate hemimethylated and unmethylated
1227:
repeats. Both domains are required for the catalytic function of DNMT1.
693:
669:
3879:
3573:
3528:
3518:
3513:
3508:
3503:
1457:
1250:
development, while the somatic DNMT1 is always found in the nucleus of
1216:
1167:
1146:
1119:
1110:
1105:
948:
are found as components of type II restriction-modification systems in
900:
819:
765:
515:
337:
94:
1366:
occur after a memorable event is imposed on a rat, such as contextual
276:
structure of human dnmt2, an enigmatic dna methyltransferase homologue
4527:
4501:
4181:
3535:
3314:
Goll MG, Bestor TH (2005). "Eukaryotic cytosine methyltransferases".
3194:
1382:
1239:
1027:
811:
792:
626:
3051:
1238:-specific isoform (DNMT1o). DNMT1o is synthesized and stored in the
4581:
3742:
3732:
3427:
3413:
3399:
3385:
2802:"Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2"
2259:"Experience-dependent epigenomic reorganization in the hippocampus"
2078:
Cheng X (February 1995). "DNA modification by methyltransferases".
1344:
1337:
1298:
1290:
1203:
1019:
1007:
995:
987:
979:
961:
957:
941:
940:
that specifically methylate the amino group at the C-4 position of
810:
into 2 domains, an N-terminal catalytic domain, which contains the
804:
800:
773:
751:
716:
711:
that specifically methylate the amino group at the C-6 position of
498:
320:
77:
936:
m4C methyltransferases (N-4 cytosine-specific DNA methylases) are
4260:
3920:
3702:
3569:
1709:
1453:
1347:
sites at a rate much slower than DNMT1, but greater than DNMT3b.
1231:
1220:
1171:
1163:
1114:
1011:
945:
930:
858:
769:
712:
708:
510:
449:
332:
271:
89:
28:
4540:
4310:
4090:
4042:
3498:
1436:
1394:
1359:
1355:
1314:
1247:
1235:
1224:
1212:
1195:
1180:
1174:
1093:
1062:
1054:
975:
937:
743:
731:
623:
589:
454:
crystal structure of methyltransferase mboiia (moraxella bovis)
423:
245:
148:
2856:"TRDMT1 tRNA aspartic acid methyltransferase 1 (Homo sapiens)"
2257:
Duke CG, Kennedy AJ, Gavin CF, Day JJ, Sweatt JD (July 2017).
1798:"DNA methyltransferases and epigenetic regulation in bacteria"
4514:
3759:
3611:
1085:
926:
3359:
Information about DNA methyltransferases and DNA methylation
2042:
1906:
1018:
of HhaI methyltransferase (M.HhaI) has been resolved to 2.5
3830:
3660:
3591:
3423:
3409:
3395:
3381:
1211:
and maintenance methylation of tumor suppressor genes. The
834:. A classification of N-MTases has been proposed, based on
551:
485:
473:
385:
307:
295:
207:
186:
110:
64:
52:
4279:
2466:
2412:
1836:
1598:
1057:, needs to alter protein expression. As an example, when
3465:
2112:
1871:
1674:
1563:
1286:
634:
2799:
1993:
2627:
1432:
are under investigation for treatment of some cancers:
1297:
DNMT3a1, DNMT3a2 and DNMT3b can mediate methylation of
968:
by type II restriction enzymes that recognise the same
3422:
This article incorporates text from the public domain
3408:
This article incorporates text from the public domain
3394:
This article incorporates text from the public domain
3380:
This article incorporates text from the public domain
3181:
Mack GS (December 2010). "To selectivity and beyond".
3037:
2721:
2628:
Smith SS, Kaplan BE, Sowers LC, Newman EM (May 1992).
1234:, the somatic DNMT1, a splice variant (DNMT1b) and an
715:
in DNA. They are found in the three existing types of
4570:
2931:
2879:
2686:
2207:"Neuroplasticity mediated by altered gene expression"
1034:
binding sites, and a smaller DNA recognition domain.
2592:
1955:
1760:
1358:. In a rat, high levels of new DNA methylations in
742:
in order to prevent the host from digesting its own
2256:
799:of N6-MTase TaqI (M.TaqI) has been resolved to 2.4
4594:
4114:3-methyl-2-oxobutanoate hydroxymethyltransferase
3365:Data for a DNA methyltransferase (DNMT) Antibody
2756:
1514:
3129:
2204:
1989:
1987:
1795:
4295:
4068:Cyclopropane-fatty-acyl-phospholipid synthase
3906:
3451:
3284:
2338:
1670:
1668:
1666:
1069:neuron genome are differentially methylated.
3969:Phosphatidylethanolamine N-methyltransferase
3174:
3123:
3074:
3031:
2982:
2873:
2509:
2339:Chen T, Ueda Y, Xie S, Li E (October 2002).
2332:
2198:
2155:
1515:Iyer LM, Zhang D, Aravind L (January 2016).
1393:takes place. The loss of DNMT3L leads to bi-
925:, was shown to play key functional roles in
726:of the hsdM gene, and in type III it is the
4132:Phosphoribosylglycinamide formyltransferase
4038:Phosphatidyl ethanolamine methyltransferase
2106:
2071:
2036:
1984:
1949:
4302:
4288:
4233:3-hydroxymethylcephem carbamoyltransferase
3913:
3899:
3458:
3444:
3313:
2988:
1754:
1703:
1663:
1628:
1592:
1557:
1377:and is required for establishing maternal
1041:
998:sequences, which are believed to modulate
448:
270:
27:
3372:at the U.S. National Library of Medicine
3157:
3147:
3106:
3083:"DNA Methylation and Establishing Memory"
3080:
3014:
2965:
2927:
2925:
2905:
2663:
2653:
2541:
2515:
2492:
2356:
2282:
2222:
2181:
2019:
1996:"The DNA (cytosine-5) methyltransferases"
1932:
1813:
1737:
1727:
1540:
3328:10.1146/annurev.biochem.74.010904.153721
2462:
2460:
1796:Adhikari S, Curtis PD (September 2016).
1408:
1139:
1098:
1065:in a rat, 9.17% of the genes in the rat
872:. In the presence of the R subunit, the
2252:
2250:
2205:McClung CA, Nestler EJ (January 2008).
1634:
964:. By this action they protect DNA from
830:form a cleft that accommodates the DNA
4595:
4243:N-acetylornithine carbamoyltransferase
4012:Betaine-homocysteine methyltransferase
3959:Phenylethanolamine N-methyltransferase
3217:
2922:
1497:Cell cycle regulated Methyltransferase
1373:DNMT3L contains DNA methyltransferase
1242:of the oocyte and translocated to the
4283:
3894:
3604:Histone acetylation and deacetylation
3439:
3249:
2457:
2080:Current Opinion in Structural Biology
2077:
1385:inactive. DNMT3L is expressed during
722:(in type I system the A-Mtase is the
4197:methylmalonyl-CoA carboxytransferase
3180:
2247:
1134:on the lysines of the histone tails.
1088:, two isoforms transcribed from the
952:. Such enzymes recognise a specific
4269:Arginine:glycine amidinotransferase
3989:Acetylserotonin O-methyltransferase
3985:5-hydroxyindole-O-methyltransferase
3370:DNA+Modification+Methyltransferases
2516:Rose NR, Klose RJ (December 2014).
265:C-5 cytosine-specific DNA methylase
13:
3242:
1460:) in phase III trials for AML and
1413:
780:in their N-terminal section, this
14:
4614:
3352:
750:. These methylases have the same
648:
4580:
4153:Glutamate formimidoyltransferase
2989:Hegde M, Joshi MB (April 2021).
2574:HUGO Gene Nomenclature Committee
2389:HUGO Gene Nomenclature Committee
2315:HUGO Gene Nomenclature Committee
2156:Oliveira PH, Fang G (May 2020).
1301:in gene promoters, resulting in
1160:post-translational modifications
1132:post-translational modifications
1030:domain containing catalytic and
933:formations and host-adaptation.
720:restriction-modification systems
4228:Putrescine carbamoyltransferase
4109:Serine hydroxymethyltransferase
3808:Archaeal transcription factor B
3130:Bayraktar G, Kreutz MR (2018).
2848:
2793:
2750:
2715:
2680:
2621:
2586:
2558:
2406:
2373:
2299:
2149:
1900:
1865:
1092:gene: DNMT3a1 and DNMT3a2, and
845:R, M and S. The M (hsdM) and S
4218:Ornithine carbamoyltransferase
4213:Aspartate carbamoyltransferase
4137:Inosine monophosphate synthase
4017:Homocysteine methyltransferase
1830:
1789:
1508:
1073:Maintenance methyltransferases
903:, the HsdM N-terminal domain.
1:
3994:Catechol-O-methyl transferase
3954:Histamine N-methyltransferase
3316:Annual Review of Biochemistry
3299:10.1016/S1521-6616(03)00204-3
3260:10.1016/s0079-6603(08)60048-3
2736:10.1158/0008-5472.CAN-05-1537
2701:10.1158/0008-5472.CAN-05-1980
1502:
1332:DNMT3a1 can co-localize with
1145:Some repression signals on a
1104:Some activation signals on a
880:, binding to the same target
546:Available protein structures:
380:Available protein structures:
202:Available protein structures:
105:Available protein structures:
4223:Oxamate carbamoyltransferase
4063:Thiopurine methyltransferase
2771:10.1016/0092-8674(92)90611-F
2595:Journal of Molecular Biology
2534:10.1016/j.bbagrm.2014.02.007
2127:10.1016/0092-8674(93)90421-L
2092:10.1016/0959-440X(95)80003-J
2057:10.1016/0022-2836(89)90480-4
2045:Journal of Molecular Biology
1970:10.1016/0378-1119(88)90299-5
1886:10.1016/j.biochi.2015.10.011
1839:Journal of Molecular Biology
1775:10.1016/0022-2836(91)80064-2
1763:Journal of Molecular Biology
1689:10.1016/0378-1119(94)00783-O
1649:10.1016/0022-2836(89)90481-6
1637:Journal of Molecular Biology
1614:10.1016/0378-1119(88)90298-3
1578:10.1016/0022-2836(87)90303-2
1566:Journal of Molecular Biology
1079:
1022:: the molecule folds into 2
784:region could be involved in
653:
7:
4309:
4238:Lysine carbamoyltransferase
3924:: one carbon transferases (
1475:
868:strands of a bipartite DNA
645:(SAM) as the methyl donor.
10:
4619:
3484:Transcriptional regulation
3421:
3407:
3393:
3379:
3007:10.1007/s00432-021-03519-4
2958:10.1038/s41467-020-14498-4
1443:) in phase III trials for
1417:
686:m5C - those that generate
674:m4C - those that generate
662:m6A - those that generate
4466:
4458:Michaelis–Menten kinetics
4430:
4399:
4368:
4317:
4255:
4205:
4189:
4170:
4145:
4122:
4099:
4080:
4048:Histone methyltransferase
4030:
4002:
3977:
3964:Amine N-methyltransferase
3946:
3933:
3851:
3816:
3790:
3715:
3681:Transcription coregulator
3673:
3650:
3627:
3617:Histone acetyltransferase
3587:Histone methyltransferase
3565:Histone-modifying enzymes
3563:
3556:
3491:
3482:
3099:10.1177/25168657211072499
2898:10.1016/j.ccr.2014.07.028
2174:10.1016/j.tim.2020.04.007
1925:10.1038/s41564-019-0613-4
1851:10.1016/j.jmb.2009.09.027
1802:FEMS Microbiology Reviews
1468:approved in 2012 for AML.
1445:myelodysplastic syndromes
1428:of the DNMT family, some
1264:
1113:consist of four pairs of
990:cells, cytosine-specific
588:
568:
550:
545:
541:
521:
509:
497:
484:
472:
464:
459:
447:
442:
422:
402:
384:
379:
375:
363:
343:
331:
319:
306:
294:
286:
281:
269:
264:
244:
224:
206:
201:
197:
185:
177:
172:
167:
147:
127:
109:
104:
100:
88:
76:
63:
51:
43:
38:
26:
21:
4350:Diffusion-limited enzyme
4101:Hydroxymethyltransferase
3374:Medical Subject Headings
3361:at epigeneticstation.com
3149:10.3389/fnmol.2018.00169
1729:10.1073/pnas.91.23.10957
1401:, it may participate in
1313:. Work with DNMT3a2, in
1277:
1186:
922:Clostridioides difficile
826:. The N- and C-terminal
734:are responsible for the
730:of the mod gene). These
3782:Internal control region
2995:J Cancer Res Clin Oncol
2826:10.1126/science.1120976
2655:10.1073/pnas.89.10.4744
2485:10.15252/embj.201797038
2435:10.1126/science.aah5143
2211:Neuropsychopharmacology
1042:De novo vs. maintenance
956:in DNA and methylate a
4158:Aminomethyltransferase
2607:10.1006/jmbi.1997.1430
2358:10.1074/jbc.M205312200
2224:10.1038/sj.npp.1301544
2162:Trends in Microbiology
2000:Nucleic Acids Research
1533:10.1002/bies.201500104
1151:
1135:
917:Caulobacter crescentus
168:HsdM N-terminal domain
4443:Eadie–Hofstee diagram
4376:Allosteric regulation
4058:DNA methyltransferase
3875:Intrinsic termination
3640:DNA methyltransferase
3093:: 25168657211072499.
2275:10.1101/lm.045112.117
1815:10.1093/femsre/fuw023
1420:Hypomethylating agent
1409:Clinical significance
1325:or the expression of
1311:transcription factors
1143:
1102:
643:S-adenosyl methionine
612:DNA methyltransferase
4453:Lineweaver–Burk plot
4053:Thymidylate synthase
3652:Chromatin remodeling
3183:Nature Biotechnology
3081:Bernstein C (2022).
2522:Biochim Biophys Acta
1352:immediate early gene
1323:alternative splicing
1259:embryonic stem cells
1004:cell differentiation
870:recognition sequence
4022:Methionine synthase
3609:Histone deacetylase
3599:Histone demethylase
3583:Histone methylation
3287:Clinical Immunology
2950:2020NatCo..11..639G
2818:2006Sci...311..395G
2646:1992PNAS...89.4744S
2427:2016Sci...354..909B
1913:Nature Microbiology
1198:. It predominantly
892:. hsdM contains an
876:can also act as an
748:restriction enzymes
4412:Enzyme superfamily
4345:Enzyme promiscuity
3136:Front Mol Neurosci
2862:. NCBI. 2010-11-01
2570:Gene Symbol Report
2385:Gene Symbol Report
2311:Gene Symbol Report
2012:10.1093/nar/22.1.1
1426:epigenetic effects
1391:genomic imprinting
1257:DNMT1 null mutant
1230:DNMT1 has several
1152:
1136:
994:methylate certain
992:methyltransferases
982:in DNA to produce
629:the transfer of a
4568:
4567:
4277:
4276:
4251:
4250:
4166:
4165:
4124:Formyltransferase
4076:
4075:
3888:
3887:
3843:RNA polymerase II
3711:
3710:
3669:
3668:
3250:Smith SS (1994).
3087:Epigenet Insights
2479:(23): 3421–3434.
2421:(6314): 909–912.
1482:Methyltransferase
1368:fear conditioning
1059:fear conditioning
984:C5-methylcytosine
851:methyltransferase
688:C5-methylcytosine
676:N4-methylcytosine
604:
603:
600:
599:
595:structure summary
438:
437:
434:
433:
429:structure summary
260:
259:
256:
255:
251:structure summary
163:
162:
159:
158:
154:structure summary
22:N-6 DNA Methylase
4610:
4585:
4584:
4576:
4448:Hanes–Woolf plot
4391:Enzyme activator
4386:Enzyme inhibitor
4360:Enzyme catalysis
4304:
4297:
4290:
4281:
4280:
4187:
4186:
4097:
4096:
3944:
3943:
3915:
3908:
3901:
3892:
3891:
3765:Response element
3748:Response element
3561:
3560:
3489:
3488:
3460:
3453:
3446:
3437:
3436:
3347:
3310:
3281:
3237:
3236:
3234:
3232:
3221:
3215:
3214:
3195:10.1038/nbt.1724
3178:
3172:
3171:
3161:
3151:
3127:
3121:
3120:
3110:
3078:
3072:
3071:
3035:
3029:
3028:
3018:
2986:
2980:
2979:
2969:
2929:
2920:
2919:
2909:
2877:
2871:
2870:
2868:
2867:
2852:
2846:
2845:
2797:
2791:
2790:
2754:
2748:
2747:
2719:
2713:
2712:
2684:
2678:
2677:
2667:
2657:
2625:
2619:
2618:
2590:
2584:
2583:
2581:
2580:
2562:
2556:
2555:
2545:
2513:
2507:
2506:
2496:
2464:
2455:
2454:
2410:
2404:
2403:
2401:
2400:
2391:. Archived from
2377:
2371:
2370:
2360:
2351:(41): 38746–54.
2336:
2330:
2329:
2327:
2326:
2317:. Archived from
2303:
2297:
2296:
2286:
2254:
2245:
2244:
2226:
2202:
2196:
2195:
2185:
2153:
2147:
2146:
2110:
2104:
2103:
2075:
2069:
2068:
2040:
2034:
2033:
2023:
1991:
1982:
1981:
1953:
1947:
1946:
1936:
1904:
1898:
1897:
1869:
1863:
1862:
1834:
1828:
1827:
1817:
1793:
1787:
1786:
1758:
1752:
1751:
1741:
1731:
1722:(23): 10957–61.
1707:
1701:
1700:
1672:
1661:
1660:
1632:
1626:
1625:
1596:
1590:
1589:
1561:
1555:
1554:
1544:
1512:
1381:, despite being
1379:genomic imprints
1166:proteins of the
849:together form a
738:of specific DNA
664:N6-methyladenine
543:
542:
452:
440:
439:
377:
376:
274:
262:
261:
199:
198:
165:
164:
102:
101:
31:
19:
18:
16:Class of enzymes
4618:
4617:
4613:
4612:
4611:
4609:
4608:
4607:
4593:
4592:
4591:
4579:
4571:
4569:
4564:
4476:Oxidoreductases
4462:
4438:Enzyme kinetics
4426:
4422:List of enzymes
4395:
4364:
4335:Catalytic triad
4313:
4308:
4278:
4273:
4247:
4201:
4179:
4162:
4141:
4118:
4089:
4072:
4026:
3998:
3973:
3929:
3919:
3889:
3884:
3859:
3853:
3847:
3812:
3786:
3707:
3665:
3646:
3629:DNA methylation
3623:
3567:
3552:
3478:
3464:
3434:
3420:
3406:
3392:
3355:
3350:
3270:
3245:
3243:Further reading
3240:
3230:
3228:
3223:
3222:
3218:
3189:(12): 1259–66.
3179:
3175:
3128:
3124:
3079:
3075:
3052:10.1038/nn.3151
3036:
3032:
2987:
2983:
2930:
2923:
2878:
2874:
2865:
2863:
2854:
2853:
2849:
2812:(5759): 395–8.
2798:
2794:
2755:
2751:
2724:Cancer Research
2720:
2716:
2689:Cancer Research
2685:
2681:
2626:
2622:
2591:
2587:
2578:
2576:
2564:
2563:
2559:
2528:(12): 1362–72.
2514:
2510:
2465:
2458:
2411:
2407:
2398:
2396:
2379:
2378:
2374:
2337:
2333:
2324:
2322:
2305:
2304:
2300:
2255:
2248:
2203:
2199:
2154:
2150:
2111:
2107:
2076:
2072:
2041:
2037:
1992:
1985:
1954:
1950:
1905:
1901:
1870:
1866:
1835:
1831:
1794:
1790:
1759:
1755:
1708:
1704:
1673:
1664:
1633:
1629:
1597:
1593:
1562:
1558:
1513:
1509:
1505:
1487:DNA methylation
1478:
1430:DNMT inhibitors
1424:Because of the
1422:
1416:
1414:DNMT inhibitors
1411:
1403:transcriptional
1334:heterochromatin
1327:non-coding RNAs
1303:gene repression
1285:is a family of
1280:
1267:
1215:is about 1,620
1202:hemimethylated
1189:
1082:
1044:
1000:gene expression
656:
651:
639:DNA methylation
455:
277:
34:
17:
12:
11:
5:
4616:
4606:
4605:
4590:
4589:
4566:
4565:
4563:
4562:
4549:
4536:
4523:
4510:
4497:
4484:
4470:
4468:
4464:
4463:
4461:
4460:
4455:
4450:
4445:
4440:
4434:
4432:
4428:
4427:
4425:
4424:
4419:
4414:
4409:
4403:
4401:
4400:Classification
4397:
4396:
4394:
4393:
4388:
4383:
4378:
4372:
4370:
4366:
4365:
4363:
4362:
4357:
4352:
4347:
4342:
4337:
4332:
4327:
4321:
4319:
4315:
4314:
4307:
4306:
4299:
4292:
4284:
4275:
4274:
4272:
4271:
4265:
4263:
4253:
4252:
4249:
4248:
4246:
4245:
4240:
4235:
4230:
4225:
4220:
4215:
4209:
4207:
4203:
4202:
4200:
4199:
4193:
4191:
4184:
4168:
4167:
4164:
4163:
4161:
4160:
4155:
4149:
4147:
4143:
4142:
4140:
4139:
4134:
4128:
4126:
4120:
4119:
4117:
4116:
4111:
4105:
4103:
4094:
4078:
4077:
4074:
4073:
4071:
4070:
4065:
4060:
4055:
4050:
4045:
4040:
4034:
4032:
4028:
4027:
4025:
4024:
4019:
4014:
4008:
4006:
4000:
3999:
3997:
3996:
3991:
3981:
3979:
3975:
3974:
3972:
3971:
3966:
3961:
3956:
3950:
3948:
3941:
3931:
3930:
3918:
3917:
3910:
3903:
3895:
3886:
3885:
3883:
3882:
3877:
3872:
3866:
3864:
3849:
3848:
3846:
3845:
3839:RNA polymerase
3833:
3827:RNA polymerase
3820:
3818:
3814:
3813:
3811:
3810:
3805:
3800:
3794:
3792:
3788:
3787:
3785:
3784:
3779:
3774:
3769:
3768:
3767:
3762:
3752:
3751:
3750:
3745:
3740:
3735:
3730:
3719:
3717:
3713:
3712:
3709:
3708:
3706:
3705:
3700:
3699:
3698:
3693:
3688:
3677:
3675:
3671:
3670:
3667:
3666:
3664:
3663:
3657:
3655:
3648:
3647:
3645:
3644:
3643:
3642:
3634:
3632:
3625:
3624:
3622:
3621:
3620:
3619:
3614:
3601:
3596:
3595:
3594:
3579:
3577:
3558:
3554:
3553:
3551:
3550:
3549:
3548:
3543:
3533:
3532:
3531:
3526:
3521:
3516:
3511:
3506:
3495:
3493:
3486:
3480:
3479:
3463:
3462:
3455:
3448:
3440:
3378:
3377:
3367:
3362:
3354:
3353:External links
3351:
3349:
3348:
3311:
3282:
3268:
3246:
3244:
3241:
3239:
3238:
3216:
3173:
3122:
3073:
3030:
3001:(4): 937–971.
2981:
2921:
2872:
2847:
2792:
2749:
2714:
2679:
2640:(10): 4744–8.
2620:
2585:
2557:
2508:
2456:
2405:
2372:
2331:
2298:
2269:(7): 278–288.
2246:
2197:
2148:
2121:(2): 299–307.
2105:
2070:
2035:
1983:
1948:
1919:(1): 166–180.
1899:
1864:
1829:
1788:
1753:
1702:
1662:
1627:
1591:
1556:
1506:
1504:
1501:
1500:
1499:
1494:
1489:
1484:
1477:
1474:
1473:
1472:
1469:
1451:
1418:Main article:
1415:
1412:
1410:
1407:
1279:
1276:
1266:
1263:
1188:
1185:
1081:
1078:
1061:creates a new
1043:
1040:
915:and CcrM from
795:activity. The
697:
696:
684:
672:
655:
652:
650:
649:Classification
647:
602:
601:
598:
597:
592:
586:
585:
572:
566:
565:
555:
548:
547:
539:
538:
525:
519:
518:
513:
507:
506:
501:
495:
494:
489:
482:
481:
476:
470:
469:
466:
462:
461:
457:
456:
453:
445:
444:
436:
435:
432:
431:
426:
420:
419:
406:
400:
399:
389:
382:
381:
373:
372:
367:
361:
360:
347:
341:
340:
335:
329:
328:
323:
317:
316:
311:
304:
303:
298:
292:
291:
288:
284:
283:
279:
278:
275:
267:
266:
258:
257:
254:
253:
248:
242:
241:
228:
222:
221:
211:
204:
203:
195:
194:
189:
183:
182:
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174:
170:
169:
161:
160:
157:
156:
151:
145:
144:
131:
125:
124:
114:
107:
106:
98:
97:
92:
86:
85:
80:
74:
73:
68:
61:
60:
55:
49:
48:
45:
41:
40:
36:
35:
32:
24:
23:
15:
9:
6:
4:
3:
2:
4615:
4604:
4601:
4600:
4598:
4588:
4583:
4578:
4577:
4574:
4560:
4556:
4555:
4550:
4547:
4543:
4542:
4537:
4534:
4530:
4529:
4524:
4521:
4517:
4516:
4511:
4508:
4504:
4503:
4498:
4495:
4491:
4490:
4485:
4482:
4478:
4477:
4472:
4471:
4469:
4465:
4459:
4456:
4454:
4451:
4449:
4446:
4444:
4441:
4439:
4436:
4435:
4433:
4429:
4423:
4420:
4418:
4417:Enzyme family
4415:
4413:
4410:
4408:
4405:
4404:
4402:
4398:
4392:
4389:
4387:
4384:
4382:
4381:Cooperativity
4379:
4377:
4374:
4373:
4371:
4367:
4361:
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4340:Oxyanion hole
4338:
4336:
4333:
4331:
4328:
4326:
4323:
4322:
4320:
4316:
4312:
4305:
4300:
4298:
4293:
4291:
4286:
4285:
4282:
4270:
4267:
4266:
4264:
4262:
4258:
4254:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4214:
4211:
4210:
4208:
4204:
4198:
4195:
4194:
4192:
4188:
4185:
4183:
4177:
4173:
4169:
4159:
4156:
4154:
4151:
4150:
4148:
4144:
4138:
4135:
4133:
4130:
4129:
4127:
4125:
4121:
4115:
4112:
4110:
4107:
4106:
4104:
4102:
4098:
4095:
4093:- and Related
4092:
4087:
4086:Hydroxymethyl
4083:
4079:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4035:
4033:
4029:
4023:
4020:
4018:
4015:
4013:
4010:
4009:
4007:
4005:
4001:
3995:
3992:
3990:
3986:
3983:
3982:
3980:
3976:
3970:
3967:
3965:
3962:
3960:
3957:
3955:
3952:
3951:
3949:
3945:
3942:
3940:
3936:
3932:
3927:
3923:
3916:
3911:
3909:
3904:
3902:
3897:
3896:
3893:
3881:
3878:
3876:
3873:
3871:
3868:
3867:
3865:
3862:
3857:
3850:
3844:
3840:
3837:
3834:
3832:
3828:
3825:
3822:
3821:
3819:
3815:
3809:
3806:
3804:
3801:
3799:
3796:
3795:
3793:
3789:
3783:
3780:
3778:
3775:
3773:
3770:
3766:
3763:
3761:
3758:
3757:
3756:
3753:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3725:
3724:
3721:
3720:
3718:
3714:
3704:
3701:
3697:
3694:
3692:
3689:
3687:
3684:
3683:
3682:
3679:
3678:
3676:
3672:
3662:
3659:
3658:
3656:
3653:
3649:
3641:
3638:
3637:
3636:
3635:
3633:
3630:
3626:
3618:
3615:
3613:
3610:
3607:
3606:
3605:
3602:
3600:
3597:
3593:
3590:
3589:
3588:
3584:
3581:
3580:
3578:
3575:
3571:
3566:
3562:
3559:
3555:
3547:
3546:trp repressor
3544:
3542:
3541:lac repressor
3539:
3538:
3537:
3534:
3530:
3527:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3501:
3500:
3497:
3496:
3494:
3490:
3487:
3485:
3481:
3476:
3472:
3468:
3467:Transcription
3461:
3456:
3454:
3449:
3447:
3442:
3441:
3438:
3433:
3429:
3425:
3419:
3415:
3411:
3405:
3401:
3397:
3391:
3387:
3383:
3375:
3371:
3368:
3366:
3363:
3360:
3357:
3356:
3345:
3341:
3337:
3333:
3329:
3325:
3321:
3317:
3312:
3308:
3304:
3300:
3296:
3292:
3288:
3283:
3279:
3275:
3271:
3269:9780125400497
3265:
3261:
3257:
3253:
3248:
3247:
3226:
3220:
3212:
3208:
3204:
3200:
3196:
3192:
3188:
3184:
3177:
3169:
3165:
3160:
3155:
3150:
3145:
3141:
3137:
3133:
3126:
3118:
3114:
3109:
3104:
3100:
3096:
3092:
3088:
3084:
3077:
3069:
3065:
3061:
3057:
3053:
3049:
3046:(8): 1111–3.
3045:
3041:
3034:
3026:
3022:
3017:
3012:
3008:
3004:
3000:
2996:
2992:
2985:
2977:
2973:
2968:
2963:
2959:
2955:
2951:
2947:
2943:
2939:
2935:
2928:
2926:
2917:
2913:
2908:
2903:
2899:
2895:
2892:(4): 577–90.
2891:
2887:
2883:
2876:
2861:
2857:
2851:
2843:
2839:
2835:
2831:
2827:
2823:
2819:
2815:
2811:
2807:
2803:
2796:
2788:
2784:
2780:
2776:
2772:
2768:
2765:(6): 915–26.
2764:
2760:
2753:
2745:
2741:
2737:
2733:
2730:(2): 729–35.
2729:
2725:
2718:
2710:
2706:
2702:
2698:
2695:(2): 682–92.
2694:
2690:
2683:
2675:
2671:
2666:
2661:
2656:
2651:
2647:
2643:
2639:
2635:
2631:
2624:
2616:
2612:
2608:
2604:
2600:
2596:
2589:
2575:
2571:
2567:
2561:
2553:
2549:
2544:
2539:
2535:
2531:
2527:
2523:
2519:
2512:
2504:
2500:
2495:
2490:
2486:
2482:
2478:
2474:
2470:
2463:
2461:
2452:
2448:
2444:
2440:
2436:
2432:
2428:
2424:
2420:
2416:
2409:
2395:on 2012-11-20
2394:
2390:
2386:
2382:
2376:
2368:
2364:
2359:
2354:
2350:
2346:
2342:
2335:
2321:on 2012-10-06
2320:
2316:
2312:
2308:
2302:
2294:
2290:
2285:
2280:
2276:
2272:
2268:
2264:
2260:
2253:
2251:
2242:
2238:
2234:
2230:
2225:
2220:
2216:
2212:
2208:
2201:
2193:
2189:
2184:
2179:
2175:
2171:
2167:
2163:
2159:
2152:
2144:
2140:
2136:
2132:
2128:
2124:
2120:
2116:
2109:
2101:
2097:
2093:
2089:
2085:
2081:
2074:
2066:
2062:
2058:
2054:
2051:(2): 305–12.
2050:
2046:
2039:
2031:
2027:
2022:
2017:
2013:
2009:
2005:
2001:
1997:
1990:
1988:
1979:
1975:
1971:
1967:
1963:
1959:
1952:
1944:
1940:
1935:
1930:
1926:
1922:
1918:
1914:
1910:
1903:
1895:
1891:
1887:
1883:
1879:
1875:
1868:
1860:
1856:
1852:
1848:
1844:
1840:
1833:
1825:
1821:
1816:
1811:
1808:(5): 575–91.
1807:
1803:
1799:
1792:
1784:
1780:
1776:
1772:
1769:(2): 431–40.
1768:
1764:
1757:
1749:
1745:
1740:
1735:
1730:
1725:
1721:
1717:
1713:
1706:
1698:
1694:
1690:
1686:
1683:(1–2): 3–11.
1682:
1678:
1671:
1669:
1667:
1658:
1654:
1650:
1646:
1643:(2): 313–21.
1642:
1638:
1631:
1623:
1619:
1615:
1611:
1607:
1603:
1595:
1587:
1583:
1579:
1575:
1572:(2): 159–70.
1571:
1567:
1560:
1552:
1548:
1543:
1538:
1534:
1530:
1526:
1522:
1518:
1511:
1507:
1498:
1495:
1493:
1492:PRMT4 pathway
1490:
1488:
1485:
1483:
1480:
1479:
1470:
1467:
1463:
1459:
1455:
1452:
1450:
1446:
1442:
1438:
1435:
1434:
1433:
1431:
1427:
1421:
1406:
1404:
1400:
1396:
1392:
1388:
1387:gametogenesis
1384:
1383:catalytically
1380:
1376:
1371:
1369:
1365:
1361:
1357:
1353:
1348:
1346:
1342:
1339:
1335:
1330:
1328:
1324:
1320:
1316:
1312:
1308:
1304:
1300:
1295:
1292:
1288:
1284:
1275:
1272:
1271:aspartic acid
1262:
1260:
1255:
1253:
1249:
1246:during early
1245:
1241:
1237:
1233:
1228:
1226:
1222:
1218:
1214:
1210:
1205:
1201:
1197:
1193:
1184:
1182:
1178:
1176:
1173:
1169:
1165:
1161:
1156:
1149:
1148:
1142:
1138:
1133:
1129:
1125:
1121:
1116:
1112:
1108:
1107:
1101:
1097:
1095:
1091:
1087:
1077:
1074:
1070:
1068:
1064:
1060:
1056:
1052:
1048:
1039:
1035:
1033:
1029:
1025:
1021:
1017:
1013:
1009:
1005:
1001:
997:
993:
989:
985:
981:
977:
972:
971:
967:
963:
959:
955:
951:
947:
944:in DNA. Such
943:
939:
934:
932:
928:
924:
923:
918:
914:
910:
904:
902:
898:
895:
894:alpha-helical
891:
887:
883:
879:
875:
871:
867:
866:complementary
863:
860:
856:
852:
848:
844:
840:
837:
833:
829:
825:
824:alpha-helices
821:
817:
813:
809:
806:
802:
798:
794:
790:
787:
783:
779:
775:
771:
767:
763:
760:
757:
753:
749:
745:
741:
737:
733:
729:
725:
721:
718:
714:
710:
705:
703:
695:
692:
689:
685:
683:
680:
677:
673:
671:
668:
665:
661:
660:
659:
646:
644:
640:
636:
632:
628:
625:
621:
617:
613:
609:
596:
593:
591:
587:
584:
580:
576:
573:
571:
567:
563:
559:
556:
553:
549:
544:
540:
537:
533:
529:
526:
524:
520:
517:
514:
512:
508:
505:
502:
500:
496:
493:
490:
487:
483:
480:
477:
475:
471:
467:
463:
458:
451:
446:
443:DNA methylase
441:
430:
427:
425:
421:
418:
414:
410:
407:
405:
401:
397:
393:
390:
387:
383:
378:
374:
371:
368:
366:
362:
359:
355:
351:
348:
346:
342:
339:
336:
334:
330:
327:
324:
322:
318:
315:
312:
309:
305:
302:
299:
297:
293:
290:DNA_methylase
289:
285:
280:
273:
268:
263:
252:
249:
247:
243:
240:
236:
232:
229:
227:
223:
219:
215:
212:
209:
205:
200:
196:
193:
190:
188:
184:
180:
176:
171:
166:
155:
152:
150:
146:
143:
139:
135:
132:
130:
126:
122:
118:
115:
112:
108:
103:
99:
96:
93:
91:
87:
84:
81:
79:
75:
72:
69:
66:
62:
59:
56:
54:
50:
46:
42:
37:
30:
25:
20:
4554:Translocases
4551:
4538:
4525:
4512:
4499:
4489:Transferases
4486:
4473:
4330:Binding site
4057:
4004:Homocysteine
3639:
3319:
3315:
3290:
3286:
3251:
3231:28 September
3229:. Retrieved
3227:. 2012-09-28
3219:
3186:
3182:
3176:
3139:
3135:
3125:
3090:
3086:
3076:
3043:
3040:Nat Neurosci
3039:
3033:
2998:
2994:
2984:
2941:
2937:
2889:
2885:
2875:
2864:. Retrieved
2859:
2850:
2809:
2805:
2795:
2762:
2758:
2752:
2727:
2723:
2717:
2692:
2688:
2682:
2637:
2633:
2623:
2601:(1): 67–79.
2598:
2594:
2588:
2577:. Retrieved
2569:
2560:
2525:
2521:
2511:
2476:
2472:
2418:
2414:
2408:
2397:. Retrieved
2393:the original
2384:
2375:
2348:
2344:
2334:
2323:. Retrieved
2319:the original
2310:
2301:
2266:
2262:
2214:
2210:
2200:
2168:(1): 28–40.
2165:
2161:
2151:
2118:
2114:
2108:
2083:
2079:
2073:
2048:
2044:
2038:
2003:
1999:
1964:(1): 261–5.
1961:
1957:
1951:
1916:
1912:
1902:
1877:
1873:
1867:
1845:(1): 79–88.
1842:
1838:
1832:
1805:
1801:
1791:
1766:
1762:
1756:
1719:
1715:
1705:
1680:
1676:
1640:
1636:
1630:
1608:(1): 253–9.
1605:
1601:
1594:
1569:
1565:
1559:
1527:(1): 27–40.
1524:
1520:
1510:
1423:
1405:repression.
1372:
1349:
1331:
1296:
1282:
1281:
1268:
1256:
1244:cell nucleus
1229:
1208:
1191:
1190:
1179:
1157:
1153:
1144:
1137:
1128:acetylations
1124:Methylations
1103:
1089:
1083:
1072:
1071:
1050:
1046:
1045:
1036:
973:
935:
920:
916:
912:
905:
878:endonuclease
843:polypeptides
706:
698:
657:
631:methyl group
622:) family of
619:
615:
611:
608:biochemistry
605:
4325:Active site
3922:Transferase
3852:Termination
3728:Pribnow box
3696:Corepressor
3691:Coactivator
3492:prokaryotic
3322:: 481–514.
3293:(1): 6–16.
2886:Cancer Cell
2860:Entrez Gene
2345:J Biol Chem
2217:(1): 3–17.
2086:(1): 4–10.
2006:(1): 1–10.
1441:azacitidine
1399:methylation
1364:hippocampus
1341:methylation
1217:amino acids
1168:nucleosomes
1130:are common
1120:chromosomes
1111:Nucleosomes
1067:hippocampus
1026:- a larger
950:prokaryotes
927:sporulation
820:beta-sheets
736:methylation
702:echinoderms
468:N6_N4_Mtase
460:Identifiers
282:Identifiers
173:Identifiers
39:Identifiers
4528:Isomerases
4502:Hydrolases
4369:Regulation
3880:Rho factor
3870:Terminator
3861:eukaryotic
3836:eukaryotic
3817:Elongation
3803:Eukaryotic
3791:Initiation
3574:nucleosome
3557:eukaryotic
3529:gal operon
3524:ara operon
3519:Gua Operon
3514:gab operon
3509:trp operon
3504:lac operon
3475:Eukaryotic
2944:(1): 639.
2938:Nat Commun
2866:2010-11-07
2579:2012-09-27
2399:2012-09-27
2325:2012-09-27
1503:References
1458:decitabine
1321:activity,
1200:methylates
1147:nucleosome
1126:{Me}, and
1106:nucleosome
901:N-terminus
890:methylated
855:methylates
791:or in the
558:structures
392:structures
214:structures
117:structures
4407:EC number
4206:Carbamoyl
4182:Carbamoyl
3856:bacterial
3824:bacterial
3798:Bacterial
3772:Insulator
3716:Promotion
3686:Activator
3536:Repressor
3471:Bacterial
3432:IPR002941
3418:IPR012327
3404:IPR003356
3390:IPR001525
2263:Learn Mem
1874:Biochimie
1521:BioEssays
1307:promoters
1299:CpG sites
1248:embryonic
1240:cytoplasm
1080:Mammalian
1028:catalytic
1016:structure
988:mammalian
980:cytosines
942:cytosines
836:conserved
832:substrate
812:catalytic
797:structure
793:catalytic
786:substrate
782:conserved
756:conserved
740:sequences
717:bacterial
694:2.1.1.37
682:2.1.1.113
654:Substrate
616:DNA MTase
516:PDOC00088
504:IPR002941
338:PDOC00089
326:IPR001525
95:PDOC00087
83:IPR003356
4603:EC 2.1.1
4597:Category
4431:Kinetics
4355:Cofactor
4318:Activity
3777:Silencer
3755:Enhancer
3743:CAAT box
3733:TATA box
3723:Promoter
3428:InterPro
3414:InterPro
3400:InterPro
3386:InterPro
3344:32123961
3336:15952895
3307:14585271
3211:11480326
3203:21139608
3168:29875631
3117:35098021
3068:10590208
3060:22751036
3025:33604794
2976:32005851
2916:25263941
2842:39089541
2834:16424344
2787:19879601
2744:16424002
2709:16423997
2566:"DNMT3L"
2552:24560929
2503:29074627
2451:30907442
2443:27856912
2381:"DNMT3B"
2367:12138111
2293:28620075
2241:18241370
2233:17728700
2192:32417228
2143:54238106
1943:31768029
1894:26475175
1880:: 60–7.
1859:19766657
1824:27476077
1551:26660621
1476:See also
1319:enhancer
1309:of many
1254:tissue.
1232:isoforms
1032:cofactor
1010:, these
1008:bacteria
970:sequence
966:cleavage
962:sequence
960:in that
958:cytosine
954:sequence
886:sequence
882:sequence
862:residues
847:subunits
816:cofactor
805:molecule
752:sequence
746:via its
713:adenines
670:2.1.1.72
627:catalyze
575:RCSB PDB
499:InterPro
409:RCSB PDB
321:InterPro
231:RCSB PDB
134:RCSB PDB
78:InterPro
47:N6_Mtase
4587:Biology
4541:Ligases
4311:Enzymes
4261:Amidine
4190:Carboxy
4176:Carboxy
3939:Methyl-
3703:Inducer
3570:histone
3278:7863011
3159:5975432
3142:: 169.
3108:8793415
3016:7954751
2967:6994722
2946:Bibcode
2907:4224113
2814:Bibcode
2806:Science
2779:1606615
2674:1584813
2642:Bibcode
2615:9451440
2543:4316174
2494:5709737
2423:Bibcode
2415:Science
2307:"DNMT1"
2284:5473107
2183:7666040
2135:8343957
2100:7773746
2065:2716049
2030:8127644
1978:3248729
1934:6925328
1783:1833555
1748:7971991
1697:7607512
1657:2541254
1622:3248728
1586:3323532
1542:4738411
1454:Dacogen
1395:allelic
1362:of the
1360:neurons
1315:neurons
1252:somatic
1209:de novo
1196:mammals
1172:histone
1164:histone
1162:on the
1115:histone
1051:De novo
1047:De novo
1024:domains
1012:enzymes
946:enzymes
938:enzymes
931:biofilm
913:E. coli
899:at the
874:complex
859:adenine
828:domains
789:binding
732:enzymes
728:product
724:product
709:enzymes
624:enzymes
511:PROSITE
479:PF01555
370:cd00315
333:PROSITE
301:PF00145
192:PF12161
90:PROSITE
58:PF02384
4573:Portal
4515:Lyases
4091:Formyl
4043:DNMT3B
3499:Operon
3376:(MeSH)
3342:
3334:
3305:
3276:
3266:
3209:
3201:
3166:
3156:
3115:
3105:
3066:
3058:
3023:
3013:
2974:
2964:
2914:
2904:
2840:
2832:
2785:
2777:
2742:
2707:
2672:
2662:
2613:
2550:
2540:
2501:
2491:
2473:EMBO J
2449:
2441:
2365:
2291:
2281:
2239:
2231:
2190:
2180:
2141:
2133:
2098:
2063:
2028:
2021:307737
2018:
1976:
1941:
1931:
1892:
1857:
1822:
1781:
1746:
1736:
1695:
1655:
1620:
1584:
1549:
1539:
1437:Vidaza
1375:motifs
1356:memory
1265:TRDMT1
1236:oocyte
1213:enzyme
1181:DNMT3L
1175:lysine
1094:DNMT3b
1090:DNMT3a
1063:memory
1055:neuron
976:carbon
909:EcoDam
897:domain
822:and 8
803:. The
744:genome
610:, the
590:PDBsum
564:
554:
536:SUPFAM
492:CL0063
465:Symbol
424:PDBsum
398:
388:
358:SUPFAM
314:CL0063
287:Symbol
246:PDBsum
220:
210:
181:HsdM_N
178:Symbol
149:PDBsum
123:
113:
71:CL0063
44:Symbol
4467:Types
4257:2.1.4
4172:2.1.3
4146:Other
4082:2.1.2
4031:Other
3935:2.1.1
3760:E-box
3612:HDAC1
3340:S2CID
3207:S2CID
3064:S2CID
2838:S2CID
2783:S2CID
2665:49160
2447:S2CID
2237:S2CID
2139:S2CID
1739:45145
1389:when
1283:DNMT3
1278:DNMT3
1192:DNMT1
1187:DNMT1
1086:DNMT1
1006:. In
986:. In
911:from
853:that
839:motif
808:folds
772:-Pro-
759:motif
532:SCOPe
523:SCOP2
354:SCOPe
345:SCOP2
4559:list
4552:EC7
4546:list
4539:EC6
4533:list
4526:EC5
4520:list
4513:EC4
4507:list
4500:EC3
4494:list
4487:EC2
4481:list
4474:EC1
4180:and
3928:2.1)
3831:rpoB
3674:both
3661:CHD7
3592:EZH2
3426:and
3424:Pfam
3412:and
3410:Pfam
3398:and
3396:Pfam
3384:and
3382:Pfam
3332:PMID
3303:PMID
3274:PMID
3264:ISBN
3233:2012
3199:PMID
3164:PMID
3113:PMID
3056:PMID
3021:PMID
2972:PMID
2912:PMID
2830:PMID
2775:PMID
2759:Cell
2740:PMID
2705:PMID
2670:PMID
2611:PMID
2548:PMID
2526:1839
2499:PMID
2439:PMID
2363:PMID
2289:PMID
2229:PMID
2188:PMID
2131:PMID
2115:Cell
2096:PMID
2061:PMID
2026:PMID
1974:PMID
1958:Gene
1939:PMID
1890:PMID
1855:PMID
1820:PMID
1779:PMID
1744:PMID
1693:PMID
1677:Gene
1653:PMID
1618:PMID
1602:Gene
1582:PMID
1547:PMID
1447:and
1002:and
857:two
814:and
620:DNMT
583:PDBj
579:PDBe
562:ECOD
552:Pfam
528:1boo
488:clan
486:Pfam
474:Pfam
417:PDBj
413:PDBe
396:ECOD
386:Pfam
350:1hmy
310:clan
308:Pfam
296:Pfam
239:PDBj
235:PDBe
218:ECOD
208:Pfam
187:Pfam
142:PDBj
138:PDBe
121:ECOD
111:Pfam
67:clan
65:Pfam
53:Pfam
3738:BRE
3324:doi
3295:doi
3291:109
3256:doi
3191:doi
3154:PMC
3144:doi
3103:PMC
3095:doi
3048:doi
3011:PMC
3003:doi
2999:147
2962:PMC
2954:doi
2902:PMC
2894:doi
2822:doi
2810:311
2767:doi
2732:doi
2697:doi
2660:PMC
2650:doi
2603:doi
2599:275
2538:PMC
2530:doi
2489:PMC
2481:doi
2431:doi
2419:354
2353:doi
2349:277
2279:PMC
2271:doi
2219:doi
2178:PMC
2170:doi
2123:doi
2088:doi
2053:doi
2049:206
2016:PMC
2008:doi
1966:doi
1929:PMC
1921:doi
1882:doi
1878:119
1847:doi
1843:395
1810:doi
1771:doi
1767:221
1734:PMC
1724:doi
1685:doi
1681:157
1645:doi
1641:206
1610:doi
1574:doi
1570:198
1537:PMC
1529:doi
1462:CML
1449:AML
1345:CpG
1338:CpG
1291:CpG
1287:DNA
1225:Lys
1221:Gly
1204:CpG
996:CpG
978:of
864:in
778:Phe
774:Tyr
770:Pro
766:Asn
762:Asp
635:DNA
633:to
606:In
570:PDB
404:PDB
365:CDD
226:PDB
129:PDB
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