Knowledge

Cycloserine

Source 📝

498: 475: 47: 38: 8142: 1063:-cycloserine combined with a single dose of ketamine was investigated for treatment resistant bipolar depression. When administered for 8 weeks after a ketamine infusion, cycloserine appeared to potentiate the antidepressant effects in all trial participants. However, a 2019 clinical trial showed no statistically significant difference between the 1067:-cycloserine and placebo groups when it came to maintaining the antidepressant effect of a single ketamine infusion. The authors suggest several possible explanations for this nonsignificance, namely the inclusion of high-risk or severely treatment-resistant participants as well as a possible confounding 1031:
The price increase was rescinded after the previous owner, the Purdue University Research Foundation, which retained "oversight of the manufacturing operation" intervened and Rodelis returned the drug to an NGO of Purdue University. The foundation now will charge $ 1,050 for 30 capsules, twice what
752:
For the treatment of tuberculosis, cycloserine is classified as a second-line drug. Its use is only considered if one or more first-line drugs cannot be used. Hence, cycloserine is restricted for use only against multiple drug-resistant and extensively drug-resistant strains of
7539: 7534: 6475: 7786: 7672: 6096: 946:
managed to synthesis the pure D-enantiomer by cyclizing the corresponding α‐amino‐β‐chlorohydroxamic acids. Chemical synthesis of the compound was revolutionized in the 2010s, when several approaches starting with the cheap
1027:
In the U.S., the price of cycloserine increased from $ 500 for 30 pills to $ 10,800 in 2015 after the Chao Center for Industrial Pharmacy and Contract Manufacturing changed ownership to Rodelis Therapeutics in August 2015.
7597: 6415: 2183:"Maintenance of antidepressant and antisuicidal effects by D-cycloserine among patients with treatment-resistant depression who responded to low-dose ketamine infusion: a double-blind randomized placebo-control study" 7569: 7791: 7677: 1116:
Polc P, Pieri L, Bonetti EP, Scherschlicht R, Moehler H, Kettler R, et al. (April 1986). "L-cycloserine: behavioural and biochemical effects after single and repeated administration to mice, rats and cats".
7516: 7766: 1864: 7888: 7585: 5971: 5677: 1928: 4569: 7457: 757:
Another reason for limited use of this drug is the neurological side effects it causes, since it is able to penetrate into the central nervous system (CNS) and cause headaches, drowsiness,
1036:
has been criticised for not ensuring that the philanthropic initiative continued. Due to US antitrust laws, however, no company may control the price of a product after it is outlicensed.
6225: 7612: 7732: 5406: 4878: 5426: 991:
A 1963 patent describes industrial production of the drug by bacterial fermentation. It is unclear what process is used in the 21st century, fermentation, or chemical synthesis.
813:
found no evidence of benefit in anxiety disorders as of 2015. Another review found preliminary evidence of benefit. Evidence for use in addiction is tentative but also unclear.
5460: 1898: 7627: 7893: 5020: 1075:-cycloserine having a stronger antisuicidal effect than placebo, the authors caution that this difference might be attributed to the placebo group feeling worse than the 7450: 6196: 5194: 2857: 7878: 7663: 6342: 1704:"Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway" 1856: 7925: 6157: 8167: 8005: 7443: 7423: 5399: 5372: 4871: 7712: 7577: 5061: 4935: 3871: 1944:"An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials" 1309: 130: 1920: 7902: 5854: 906:
agonism, which improves neural plasticity in lab animals. The degree of clinical usefulness is, as aforementioned, very unclear and still being explored.
8116: 7416: 7942: 7702: 2782: 8120: 8112: 7776: 5392: 4864: 7727: 6739: 5864: 7687: 6181: 2850: 7324: 6575: 6347: 6166: 4995: 925:. Cycloserine can be conceptualized as a cyclized version of serine, with an oxidative loss of dihydrogen to form the nitrogen-oxygen bond. 82: 8038: 7771: 7707: 7093: 7078: 6610: 6480: 6440: 5783: 2772: 2287: 1626:
Silverman R (1998). "An Aromatization Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase for the Antibiotic l-Cycloserine".
591: 7329: 7309: 7304: 7261: 7088: 7058: 6749: 6647: 6620: 6570: 6537: 6517: 6512: 6455: 6450: 6435: 6425: 6405: 6400: 5991: 5951: 5899: 5637: 5572: 5562: 5557: 5361: 5035: 5015: 4152: 7635: 7617: 6605: 6590: 6362: 6357: 6245: 2244: 1216: 3018: 7125: 7120: 7115: 7110: 6642: 6062: 5537: 2843: 2265: 1890: 936:
Initial approaches to synthesize the compound was first published in 1955, when the Stammer group produced a racemic synthesis from
7990: 7850: 7845: 5732: 1770:
Kuehl Jr FA, Wolf FJ, Trenner NR, Peck RL, Buhs RP, Howe E, et al. (1955). "D-4-Amino-3-isoxazolidinone, a new antibiotic".
2958: 2947: 7832: 6625: 6460: 5874: 5707: 5642: 2141: 1828:
Hidy PH, Hodge EB, Young VV, Harned RL, Brewer GA, Phillips WF, et al. (1955). "Structure and reactions of cycloserine".
1177: 8182: 6507: 4096: 2801: 736: 1051:-cycloserine aids in learning by helping form stronger neural connections. It has been investigated as an aid to facilitate 4270: 2369: 1535:"Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by the antibiotic D-cycloserine" 5178: 7493: 7344: 6171: 636: 4856: 1259: 5354: 2787: 1210: 1039:
In 2015, the cost in the United States was increased to US$ 3,150 a month and then decreased to US$ 1,050 per month.
611: 119: 8162: 7650: 4113: 2818: 2280: 2835: 8177: 4145: 2777: 248: 160: 100: 1325:"Augmentation of cognitive and behavioural therapies (CBT) with d-cycloserine for anxiety and related disorders" 6329: 4015: 3901: 845: 2044:"Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders" 6077: 5415: 4239: 1305: 8108: 7985: 7484: 7409: 5347: 4910: 4589: 4564: 4204: 3067: 493: 354: 6704: 3926: 3846: 2973: 2907: 2472: 2273: 670: 666: 654: 567: 454: 8132: 7980: 7865: 7855: 6497: 4138: 899:-alanine molecules cannot be joined. This effectively leads to inhibition of peptidoglycan synthesis. 423: 8172: 5242: 4657: 4344: 4275: 3851: 2978: 2295: 1230: 801:
can reduce the incidence of some of these CNS side effects (e.g. convulsions) caused by cycloserine.
701: 1587:"Initial characterization of D-cycloserine for future formulation development for anxiety disorders" 8071: 7912: 6130: 5140: 4594: 2874: 2554: 470: 3780: 1993:"D-cycloserine as an augmentation strategy for cognitive behavioral therapy for anxiety disorders" 443: 8058: 7952: 7359: 5199: 5124: 4955: 4707: 4599: 4265: 4101: 3916: 3876: 2983: 2891: 2806: 2440: 2424: 59: 7435: 2142:"Single-Dose Ketamine Followed by Daily d-Cycloserine in Treatment-Resistant Bipolar Depression" 988:
successfully used recombinant versions of three enzymes in the cluster to produce the compound.
8043: 7682: 7549: 7234: 6709: 6502: 6314: 6305: 5214: 4712: 4579: 4559: 4524: 4424: 3940: 3891: 3881: 3636: 3408: 2532: 2429: 2317: 2300: 1084: 872: 4887: 3669: 3501: 3320: 403: 7476: 7473: 7229: 4902: 4702: 4619: 4234: 3921: 3906: 3886: 2599: 2419: 1200: 2248: 1059:
and anxiety disorders, and treatment with schizophrenia. In a open label trial, a course of
8020: 6352: 6067: 5808: 5384: 5272: 4629: 4604: 4224: 4219: 4005: 3911: 3856: 2767: 2445: 363: 215: 5204: 1801:, Brewer GA, Phillips WF, et al. (1955). "Synthesis of D-4-amino-3-isoxazolidinone". 343: 8: 8076: 8010: 7965: 7883: 6714: 6120: 5547: 5445: 5209: 5145: 3896: 3866: 3715: 3677: 269: 7561: 7281: 928:
Cycloserine is stable under basic conditions, with the greatest stability at pH = 11.5.
497: 474: 278: 8033: 7524: 6657: 6652: 6492: 6336: 5418: 4886: 4609: 4450: 4429: 4378: 2226: 2213: 2182: 2181:
Chen MH, Cheng CM, Gueorguieva R, Lin WC, Li CT, Hong CJ, et al. (November 2019).
2117: 2092: 2068: 2043: 2019: 1992: 1968: 1943: 1728: 1703: 1679: 1654: 1564: 1450: 1425: 1401: 1376: 1349: 1324: 1142: 677: 1499: 1474: 7239: 6145: 6041: 5859: 5752: 5427: 5267: 4419: 4393: 3431: 3137: 2912: 2304: 2296: 2230: 2218: 2163: 2122: 2073: 2059: 2024: 1973: 1733: 1684: 1608: 1556: 1504: 1455: 1406: 1354: 1284: 1206: 1134: 1130: 758: 175: 1568: 8048: 7809: 7741: 6794: 6111: 6057: 5835: 5773: 5450: 5257: 5066: 4919: 4899: 4823: 4780: 4574: 4161: 4019: 3170: 2968: 2865: 2208: 2198: 2153: 2112: 2104: 2063: 2055: 2014: 2004: 1963: 1959: 1955: 1837: 1810: 1779: 1723: 1715: 1674: 1666: 1635: 1598: 1546: 1494: 1486: 1445: 1441: 1437: 1426:"D-cycloserine effects on extinction of conditioned responses to drug-related cues" 1396: 1388: 1344: 1340: 1336: 1274: 1238: 1173: 1126: 1080: 1068: 1052: 841: 510: 185: 143: 92: 46: 2093:"D-cycloserine: an evolving role in learning and neuroplasticity in schizophrenia" 1752: 1490: 1146: 8187: 8146: 7995: 7692: 7294: 7244: 7004: 6924: 6889: 6789: 6230: 6140: 5909: 5485: 5247: 4775: 3807: 3251: 3078: 2595: 2586: 2194: 810: 303: 203: 193: 2882: 2878: 1921:"Learning and Brain Activity Are Boosted by a Dose of a Small-Molecule Compound" 1585:
Kaushal G, Ramirez R, Alambo D, Taupradist W, Choksi K, Sirbu C (October 2011).
1109: 8081: 7756: 7697: 7204: 7184: 6949: 6884: 6804: 6784: 6580: 6052: 5981: 5768: 5687: 5150: 5091: 5081: 5056: 4990: 4837: 4455: 4398: 4363: 4229: 4107: 3037: 2812: 2737: 2481: 2331: 1000: 999:
The compound was first isolated nearly simultaneously by two teams. Workers at
884: 794: 693: 2203: 1603: 1586: 8156: 8089: 8000: 7934: 7751: 7717: 7602: 7529: 7511: 7374: 7369: 7349: 7209: 7174: 7029: 7024: 7014: 6989: 6984: 6919: 6879: 6839: 6420: 6125: 6037: 5976: 5921: 5889: 5748: 5682: 5502: 5475: 5297: 5277: 5229: 5168: 5158: 4980: 4828: 4755: 4470: 4199: 4001: 3860: 3475: 3303: 3215: 3209: 3155: 3151: 3121: 3116: 3111: 3106: 3096: 3032: 3003: 2993: 2671: 2658: 2649: 2563: 2509: 1475:"Mechanism of D-cycloserine action: alanine racemase from Escherichia coli W" 1258:
Nitsche MA, Jaussi W, Liebetanz D, Lang N, Tergau F, Paulus W (August 2004).
1016: 915: 903: 837: 578: 486: 2108: 29: 7164: 6994: 6964: 6869: 6834: 6769: 6754: 6532: 6033: 6006: 5961: 5758: 5744: 5712: 5662: 5617: 5262: 4960: 4809: 4789: 4644: 4511: 4434: 4336: 3770: 3687: 3530: 3388: 3373: 3179: 3008: 2709: 2642: 2633: 2620: 2499: 2458: 2453: 2308: 2222: 2167: 2126: 2077: 2028: 2009: 1977: 1798: 1737: 1670: 1612: 1560: 1459: 1410: 1358: 1288: 1279: 1235:
World Health Organization model list of essential medicines: 21st list 2019
822: 766: 731: 662: 434: 138: 5051: 4940: 4296: 2042:
Singewald N, Schmuckermair C, Whittle N, Holmes A, Ressler KJ (May 2015).
1688: 1508: 1392: 1323:
Ori R, Amos T, Bergman H, Soares-Weiser K, Ipser JC, Stein DJ (May 2015).
1138: 984:-serine, then turned into the final compound by cyclization. In 2013, Uda 19:
This article is about the tuberculosis medicine. For the nerve agent, see
7975: 7804: 7799: 7781: 7640: 7544: 7506: 7354: 7339: 7319: 7289: 7219: 7103: 7083: 7073: 7068: 7048: 7009: 6959: 6954: 6939: 6929: 6894: 6844: 6814: 6809: 6799: 6719: 6662: 6615: 6522: 6470: 6385: 6271: 6186: 5894: 5879: 5825: 5813: 5627: 5602: 5490: 5465: 5326: 5318: 5096: 4634: 4306: 4209: 4082: 4060: 4029: 3949: 3829: 3819: 3705: 3697: 3682: 3596: 3566: 3561: 3556: 3551: 3546: 3525: 3514: 3486: 3480: 3436: 3398: 3378: 3363: 3311: 3189: 3146: 3087: 3053: 3028: 2998: 2988: 2866: 2731: 2697: 2663: 2653: 2540: 2397: 2350: 2158: 1719: 1096: 778: 689: 3957:
Insert into bacterial cell wall causing perforation and depolarization:
1841: 1814: 1783: 1260:"Consolidation of human motor cortical neuroplasticity by D-cycloserine" 1243: 323: 7746: 7469: 7392: 7364: 7314: 7299: 7276: 7271: 7266: 7199: 7169: 7159: 7098: 7034: 7019: 6999: 6944: 6914: 6899: 6874: 6859: 6824: 6819: 6779: 6774: 6744: 6729: 6689: 6667: 6630: 6600: 6585: 6565: 6323: 6293: 6276: 6266: 6021: 6011: 5986: 5941: 5818: 5803: 5798: 5778: 5737: 5727: 5717: 5697: 5692: 5652: 5647: 5607: 5597: 5582: 5522: 5497: 5287: 5282: 5251: 5237: 5219: 5101: 5010: 4970: 4945: 4895: 4676: 4584: 4465: 4460: 4442: 4388: 4169: 4070: 4065: 4033: 4009: 3980: 3958: 3824: 3797: 3747: 3728: 3659: 3649: 3611: 3601: 3591: 3576: 3571: 3519: 3490: 3456: 3446: 3426: 3383: 3353: 3348: 3338: 3307: 3233: 3205: 3184: 3160: 3101: 3092: 2933: 2749: 2725: 2713: 2603: 2382: 2365: 2340: 1551: 1534: 1092: 798: 770: 713: 705: 685: 658: 543: 334: 20: 4624: 1639: 867:-alanine form. The second enzyme is involved in joining two of these 7970: 7761: 7466: 7189: 7179: 7137: 7063: 7053: 6979: 6974: 6934: 6909: 6904: 6854: 6829: 6759: 6734: 6724: 6699: 6694: 6684: 6560: 6445: 6430: 6410: 6395: 6390: 6281: 6106: 6101: 6047: 5936: 5931: 5926: 5884: 5793: 5788: 5763: 5672: 5612: 5592: 5587: 5577: 5567: 5542: 5470: 5432:
Tooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
5224: 5086: 5025: 4693: 4497: 4403: 4316: 4077: 3963: 3814: 3792: 3765: 3760: 3755: 3733: 3723: 3654: 3625: 3616: 3586: 3541: 3465: 3460: 3451: 3441: 3421: 3393: 3368: 3358: 3343: 3333: 3328: 3288: 3283: 3276: 3265: 3255: 3246: 3127: 3048: 3043: 2870: 2743: 2720: 2692: 2637: 2629: 2522: 2517: 2494: 2402: 2355: 2345: 2326: 1033: 1008: 1003:
isolated the compound, which they called oxamycin, from a species of
833: 774: 723: 716: 709: 289: 228: 86: 4130: 7622: 7607: 7334: 7132: 7039: 6864: 6849: 6764: 6679: 6595: 6485: 6367: 6298: 6288: 6150: 6016: 5914: 5722: 5036: 5005: 4985: 4975: 4614: 4478: 4383: 4194: 4053: 3644: 3620: 3606: 3581: 3536: 3509: 3470: 3416: 3271: 3260: 2704: 2489: 2387: 2041: 1702:
Uda N, Matoba Y, Kumagai T, Oda K, Noda M, Sugiyama M (June 2013).
960:
The biosynthesis of the compound is defined by a ten-gene cluster.
954: 797:
consumption may increase the risk of seizures. Coadministration of
786: 697: 681: 383: 314: 114: 1655:"Principles of plastic surgery of congenital facial abnormalities" 566: 7465: 7378: 7224: 7214: 7194: 7149: 6635: 6250: 6235: 6201: 6135: 6026: 5904: 5622: 5552: 5532: 5480: 5076: 4965: 4814: 4730: 4326: 4311: 4301: 4291: 4244: 4214: 2572: 2377: 1377:"D-Cycloserine in Neuropsychiatric Diseases: A Systematic Review" 891:-alanine molecules. If both of these enzymes are inhibited, then 826: 782: 762: 712:
is safe for the baby. Cycloserine is similar in structure to the
1071:
from the ketamine infusion phase. Although the results point to
1007:. The same team prepared the molecule synthetically. Workers at 859:
is a pyridoxal 5'-phosphate-dependent enzyme which converts the
832:, cycloserine acts against two crucial enzymes important in the 7823: 7254: 7154: 6527: 6258: 6240: 6217: 5512: 5507: 5115: 5000: 4950: 4321: 4249: 3803: 3299: 2392: 919: 914:
Under mildly acidic conditions, cycloserine hydrolyzes to give
856: 781:, and shaking (tremors). Overdose of cycloserine may result in 414: 233: 7833: 1584: 871:-alanine residues together by catalyzing the formation of the 722:
and works by interfering with the formation of the bacteria's
619:
InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
37: 7249: 6674: 6465: 6191: 6001: 5527: 5517: 4543: 4349: 3788: 3237: 2937: 2610: 2139: 1115: 557: 394: 208: 5414: 459: 7722: 7142: 6969: 6555: 6542: 6176: 5996: 5966: 5956: 5869: 5702: 5667: 5657: 5455: 5071: 1322: 1056: 821:
Cycloserine works as an antibiotic by inhibiting cell-wall
790: 374: 7494: 1257: 6380: 1229: 7651: 5179: 1247:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. 2180: 1891:"Big Price Increase for Tuberculosis Drug Is Rescinded" 1769: 737:
World Health Organization's List of Essential Medicines
6672:
Uncompetitive pore blockers (mostly dizocilpine site):
1753:"US3090730A Process for the production of cycloserine" 8130: 6078: 3872:
Benzathine benzylpenicillin/procaine benzylpenicillin
2140:
Kantrowitz J, Halberstam B, Gangwisch J (June 2015).
1857:"Drug Goes From $ 13.50 a Tablet to $ 750, Overnight" 1205:. Springer Science & Business Media. p. 41. 1176:. The American Society of Health-System Pharmacists. 1827: 1796: 1466: 1381:
The International Journal of Neuropsychopharmacology
895:-alanine residues cannot form and previously formed 5041:
Tooltip Vesicular inhibitory amino acid transporter
1701: 7866: 2783:Isoniazid/pyridoxine/sulfamethoxazole/trimethoprim 1990: 1532: 729:Cycloserine was discovered in 1954 from a type of 4748: 8154: 7913: 942:‐β‐aminoxyalanine ethyl ester. In 1957, Platter 302: 8059: 7953: 5125: 4768: 4692: 4552: 1251: 277: 7838:Tooltip Glutamine aminohydrolase (glutaminase) 6330: 6315: 1619: 1472: 1370: 1368: 902:Psychiatric use is suggested based on partial 583:155 to 156 °C (311 to 313 °F) (dec.) 8168:World Health Organization essential medicines 7451: 5400: 4872: 4146: 2851: 2281: 1941: 1423: 8021: 2773:Ethambutol/isoniazid/pyrazinamide/rifampicin 1533:Prosser GA, de Carvalho LP (February 2013). 1374: 1198: 1091:-cycloserine and the atypical antipsychotic 665:. Specifically it is used, along with other 442: 118: 4888: 2245:"Official page about NeuroRX NRX100/NRX101" 1991:Hofmann SG, Wu QJ, Boettcher H (May 2013). 1884: 1882: 1365: 1329:The Cochrane Database of Systematic Reviews 1015:. It was shown to hydrolyze to serine and 692:. It is not recommended in people who have 8117:Metabotropic glutamate receptor modulators 7499:Tooltip Excitatory amino acid transporters 7458: 7444: 7417:Metabotropic glutamate receptor modulators 5407: 5393: 4879: 4865: 4685: 4153: 4139: 2858: 2844: 2288: 2274: 1580: 1578: 1528: 1526: 1524: 1522: 1520: 1518: 1168: 1166: 1164: 1162: 1160: 1158: 1156: 496: 473: 342: 7424:Glutamate metabolism/transport modulators 5373:Glutamate metabolism/transport modulators 4802: 3979:Inhibits PG elongation and crosslinking: 2212: 2202: 2157: 2116: 2067: 2018: 2008: 1967: 1727: 1678: 1625: 1602: 1550: 1498: 1449: 1400: 1348: 1278: 1242: 1047:Some experimental evidence suggests that 362: 8121:GABA metabolism and transport modulators 8113:Ionotropic glutamate receptor modulators 7656:Tooltip Vesicular glutamate transporters 5836: 5273:Valproate semisodium (divalproex sodium) 5184:Tooltip γ-Aminobutyrate aminotransferase 4920: 1942:Bowers ME, Ressler KJ (September 2015). 1879: 1830:Journal of the American Chemical Society 1803:Journal of the American Chemical Society 1772:Journal of the American Chemical Society 1628:Journal of the American Chemical Society 1997:Biology of Mood & Anxiety Disorders 1888: 1854: 1848: 1575: 1515: 1153: 469: 322: 77:-cycloserine, 4-amino-3-isoxazolidinone 8155: 7147:Alcohols/volatile anesthetics/related: 1901:from the original on 26 September 2015 1867:from the original on 25 September 2015 1750: 1223: 1011:isolated the compound from strains of 957:) were published by different groups. 909: 825:in bacteria. As a cyclic analogue of 816: 487: 7693:Amido black 10B (naphthol blue black) 7439: 6303:Other positive allosteric modulators: 6083:Tooltip N-Methyl-D-aspartate receptor 5388: 4860: 4160: 4134: 2839: 2269: 1708:Antimicrobial Agents and Chemotherapy 1300: 1298: 1237:. Geneva: World Health Organization. 1180:from the original on 20 December 2016 422: 402: 169: 109: 91: 2090: 1652: 1473:Lambert MP, Neuhaus FC (June 1972). 972:-arginine are converted to O-ureido- 142: 7044:Ifenprodil (NR2B) site antagonists: 4961:Deramciclane (EGIS-3886, EGYT-3886) 2197:(published 2019-08-17): 2112–2118. 1591:Drug Discoveries & Therapeutics 1424:Myers KM, Carlezon WA (June 2012). 1306:"CYCLOSERINE: Human Health Effects" 382: 293: 13: 7871:Tooltip Aspartate aminotransferase 5608:Pesampator (BIIB-104, PF-04958242) 2146:The Journal of Clinical Psychiatry 1913: 1295: 14: 8199: 4004:subunit synthesis and transport: 2788:Rifampicin/isoniazid/pyrazinamide 1375:Schade S, Paulus W (April 2016). 1308:. National Institutes of Health. 8140: 7918:Tooltip Alanine aminotransferase 2060:10.1016/j.pharmthera.2014.12.004 1931:from the original on 2015-12-23. 1312:from the original on 2014-04-16. 1219:from the original on 2016-12-20. 1097:acute suicidal ideation/behavior 527: 521: 45: 36: 8064:Tooltip Glutamate decarboxylase 7958:Tooltip Glutamate dehydrogenase 7084:Rislenemdaz (CERC-301, MK-0657) 6031:Negative allosteric modulators: 5919:Positive allosteric modulators: 5742:Negative allosteric modulators: 5495:Positive allosteric modulators: 5130:Tooltip Glutamate decarboxylase 2778:Ethambutol/isoniazid/rifampicin 2237: 2174: 2133: 2084: 2048:Pharmacology & Therapeutics 2035: 1984: 1935: 1889:Pollack A (21 September 2015). 1855:Pollack A (20 September 2015). 1821: 1790: 1763: 1744: 1695: 1646: 1079:-cycloserine feeling better. A 953:-serine (mirror form of normal 747: 742: 624:Key:DYDCUQKUCUHJBH-UWTATZPHSA-N 223:10 hrs (normal kidney function) 8049:Phosphinothricin (glufosinate) 6320:Tooltip Dehydroepiandrosterone 5628:Tulrampator (S-47445, CX-1632) 5523:Farampator (CX-691, ORG-24448) 4399:Norepinephrine (noradrenaline) 3902:Imipenem/cilastatin/relebactam 1960:10.1016/j.biopsych.2015.06.008 1442:10.1016/j.biopsych.2012.02.030 1417: 1341:10.1002/14651858.CD007803.pub2 1316: 1192: 708:. It is unclear if use during 533: 515: 260:)-4-Amino-1,2-oxazolidin-3-one 1: 8109:Receptor/signaling modulators 7410:Receptor/signaling modulators 7259:Unknown/unsorted antagonists: 5823:Unknown/unsorted antagonists: 5416:Ionotropic glutamate receptor 5348:Receptor/signaling modulators 1797:Hidy PH, Hodge EB, Young VV, 1491:10.1128/JB.110.3.978-987.1972 1102: 978:-serine, flipped to O-ureido- 804: 8183:GABA transaminase inhibitors 8026:Tooltip Glutamine synthetase 5366:receptor positive modulators 1199:Gottlieb D, Shaw PD (2012). 1131:10.1016/0028-3908(86)90236-4 1022: 931: 676:Common side effects include 667:antituberculosis medications 649:, sold under the brand name 7: 7108:NR2A-selective antagonists: 6640:Polyamine site antagonists: 5865:Acromelic acid (acromelate) 5451:Acromelic acid (acromelate) 4893:Tooltip γ-Aminobutyric acid 3927:Ticarcillin/clavulanic acid 3847:Amoxicillin/clavulanic acid 2984:Phenoxymethylpenicillin (V) 2974:Benzathine benzylpenicillin 2672:Thioacetazone (amithiozone) 2473:Protein synthesis inhibitor 1653:Holt GR (6 December 2021). 1125:(4). Elsevier BV: 411–418. 1042: 671:drug resistant tuberculosis 655:GABA transaminase inhibitor 10: 8204: 5548:Hydrochlorothiazide (HCTZ) 2091:Goff DC (September 2012). 994: 505:Chemical and physical data 18: 8102: 8057: 8019: 7951: 7911: 7864: 7831: 7822: 7752:Glutamic acid (glutamate) 7718:Aspartic acid (aspartate) 7649: 7573:-CCG-III ((2S,3S,4R)-CCG) 7530:Glutamic acid (glutamate) 7512:Aspartic acid (aspartate) 7492: 7483: 7401: 6490:Glycine site antagonists: 6076: 5834: 5425: 5339: 5317: 5310: 5195:3-Hydrazinopropionic acid 5177: 5123: 5114: 5034: 4918: 4909: 4741: 4729: 4675: 4652: 4643: 4542: 4519: 4510: 4490: 4412: 4371: 4362: 4335: 4284: 4258: 4205:Glutamic acid (glutamate) 4200:Aspartic acid (aspartate) 4187: 4178: 4168: 4091: 4043: 3993: 3972: 3948: 3939: 3852:Ampicillin/flucloxacillin 3839: 3779: 3746: 3714: 3696: 3668: 3635: 3500: 3407: 3319: 3298: 3232: 3198: 3169: 3136: 3077: 3066: 3017: 2979:Procaine benzylpenicillin 2957: 2946: 2932: 2890: 2796: 2760: 2684: 2619: 2585: 2562: 2553: 2531: 2508: 2480: 2471: 2439: 2411: 2364: 2325: 2316: 2204:10.1038/s41386-019-0480-y 1751:Harned RL (21 May 1963). 1604:10.5582/ddt.2011.v5.5.253 1231:World Health Organization 632: 607: 587: 577: 555: 542: 509: 504: 485: 453: 433: 413: 393: 373: 353: 333: 313: 288: 268: 244: 239: 227: 214: 202: 192: 184: 159: 154: 129: 99: 81: 68: 58: 53: 44: 35: 8072:3-Mercaptopropionic acid 7581:-Serine-O-sulphate (SOS) 6378:Competitive antagonists: 6286:Polyamine site agonists: 6272:Neboglamine (nebostinel) 5841:Tooltip Kainate receptor 5355:GABA receptor modulators 5141:3-Mercaptopropionic acid 4925:Tooltip GABA transporter 4389:Epinephrine (adrenaline) 2555:Cell envelope antibiotic 2441:Topoisomerase inhibitors 1013:Streptomyces orchidaceus 673:. It is given by mouth. 8163:Anti-tuberculosis drugs 7879:2-Amino-3-butenoic acid 7673:6-(4'-Phenylstyryl)-QDC 7557:-3-Hydroxyaspartic acid 7360:Pentamidine isethionate 7104:Traxoprodil (CP-101606) 6343:Epipregnanolone sulfate 3917:Piperacillin/tazobactam 3877:Cefepime/enmetazobactam 2533:Polypeptide antibiotics 2425:Calcium aminosalicylate 2187:Neuropsychopharmacology 1479:Journal of Bacteriology 1267:Neuropsychopharmacology 1095:is being developed for 16:Tuberculosis medication 8178:NMDA receptor agonists 8044:Methionine sulfoximine 7631:-3-Methylglutamic acid 7390:Allosteric modulators: 7325:Ipenoxazone (MLV-6976) 6980:Pethidine (meperidine) 6601:Licostinel (ACEA-1021) 6523:Apimostinel (NRX-1074) 6187:Apimostinel (NRX-1074) 6155:Glycine site agonists: 5987:Licostinel (ACEA-1021) 5698:Licostinel (ACEA-1021) 5583:Mibampator (LY-451395) 4824:Carbonyl sulfide (COS) 4425:N-Methylphenethylamine 4008:synthesis inhibition ( 3892:Ceftolozane/tazobactam 3882:Cefoperazone/sulbactam 3781:β-lactamase inhibitors 2430:Sodium aminosalicylate 2318:Nucleic acid inhibitor 2301:tuberculosis treatment 2097:Schizophrenia Bulletin 2010:10.1186/2045-5380-3-11 1671:10.1002/cmdc.202100503 1659:Facial Plastic Surgery 1280:10.1038/sj.npp.1300517 1085:cycloserine/lurasidone 887:between the resulting 7059:CO-101244 (PD-174494) 6775:Delucemine (NPS-1506) 6725:Alazocine (SKF-10047) 4565:2-AGE (noladin ether) 3922:Sulbactam/durlobactam 3907:Meropenem/vaborbactam 3887:Ceftazidime/avibactam 3019:β-lactamase resistant 2959:β-lactamase sensitive 2600:arabinosyltransferase 2420:4-Aminosalicylic acid 2109:10.1093/schbul/sbs012 1948:Biological Psychiatry 1430:Biological Psychiatry 773:, hyperirritability, 7898:-Methylene-aspartate 7079:Radiprodil (RGH-896) 7054:Buphenine (nylidrin) 6631:Rapastinel (GLYX-13) 6446:Midafotel (d-CPPene) 6353:Pregnenolone sulfate 6277:Rapastinel (GLYX-13) 6068:Pregnenolone sulfate 5809:Pregnenolone sulfate 4776:Carbon monoxide (CO) 3912:Panipenem/betamipron 3857:Ampicillin/sulbactam 2969:Benzylpenicillin (G) 2903:cell wall by binding 2768:Ethambutol/isoniazid 2159:10.4088/JCP.14l09527 1720:10.1128/AAC.02291-12 1032:it charged before". 688:, unsteadiness, and 8011:Pyridoxal phosphate 7713:Chicago sky blue 6B 7678:6-Biphenyl-4-yl-QDC 6310:-Hydroxycholesterol 6121:Homoquinolinic acid 6094:Main site agonists: 5852:Main site agonists: 5446:5-Fluorowillardiine 5443:Main site agonists: 5062:Chicago sky blue 6B 4936:4-Aminovaleric acid 4781:Hydrogen sulfide (H 4635:Virodhamine (O-AEA) 3897:Imipenem/cilastatin 3867:Aztreonam/avibactam 3678:Ceftaroline fosamil 2636:synth. inhibition: 1925:Scientific American 1842:10.1021/ja01613a106 1815:10.1021/ja01613a107 1784:10.1021/ja01613a105 1393:10.1093/ijnp/pyv102 1202:Mechanism of Action 910:Chemical properties 817:Mechanism of action 32: 8034:2-Aminoadipic acid 7903:Hydrazinosuccinate 6658:Diethylenetriamine 6337:prasterone sulfate 6112:Homocysteic acid ( 5855:5-Bromowillardiine 4838:Sulfur dioxide (SO 4749:Cholinergic system 4451:Phenylethanolamine 4430:N-Methyltryptamine 4394:NAS (normelatonin) 4181:inhibitory systems 4179:Major excitatory / 4118:Never to phase III 4050:Hydrolyze NAM-NAG 3138:Carboxypenicillins 2901:layer of bacterial 2897:(inhibit synthesis 2823:Never to phase III 2305:leprostatic agents 2297:Antimycobacterials 1861:The New York Times 1552:10.1111/febs.12108 678:allergic reactions 28: 8128: 8127: 8098: 8097: 8084: 7818: 7817: 7736: 7733:Erythro-4-methyl- 7667: 7588: 7580: 7572: 7564: 7552: 7433: 7432: 7284: 7240:Trichloroethylene 7185:Ethanol (alcohol) 6550: 6493:4-Cl-KYN (AV-101) 6261: 6253: 6220: 6212: 6204: 6161: 6146:Tetrazolylglycine 6115: 6053:Ethanol (alcohol) 6042:sodium thiopental 5860:5-Iodowillardiine 5769:Ethanol (alcohol) 5753:sodium thiopental 5382: 5381: 5335: 5334: 5306: 5305: 5268:Valproate pivoxil 5232: 5205:γ-Acetylenic-GABA 5110: 5109: 4854: 4853: 4850: 4849: 4798: 4797: 4790:Nitric oxide (NO) 4764: 4763: 4737: 4725: 4724: 4721: 4720: 4671: 4670: 4667: 4666: 4538: 4537: 4534: 4533: 4506: 4505: 4420:3-Iodothyronamine 4358: 4357: 4162:Neurotransmitters 4128: 4127: 3989: 3988: 3935: 3934: 3742: 3741: 3524:Antipseudomonal ( 3432:Cefuroxime axetil 3228: 3227: 3224: 3223: 3171:Ureidopenicillins 3062: 3061: 2926: 2919: 2915: 2905:to and inhibiting 2833: 2832: 2680: 2679: 2670:Others/unsorted: 2549: 2548: 2467: 2466: 1640:10.1021/ja972907b 1634:(10): 2256–2267. 1119:Neuropharmacology 1090: 1078: 1074: 1066: 1062: 1050: 922: 898: 894: 890: 882: 878: 870: 866: 862: 855:(Ddl). The first 852: 848: 829: 719: 644: 643: 568:Interactive image 455:CompTox Dashboard 173: 112: 8195: 8173:Isoxazolidinones 8145: 8144: 8143: 8136: 8082: 8065: 8061: 8027: 8023: 7959: 7955: 7943:Propargylglycine 7937: 7929: 7919: 7915: 7897: 7872: 7868: 7839: 7835: 7829: 7828: 7810:Xanthurenic acid 7734: 7703:Benzopurpurin 4B 7665: 7657: 7653: 7586: 7578: 7570: 7562: 7550: 7500: 7496: 7490: 7489: 7460: 7453: 7446: 7437: 7436: 7282: 7235:Trichloroethanol 6795:Dextromethorphan 6548: 6332: 6321: 6317: 6259: 6251: 6218: 6210: 6202: 6159: 6113: 6084: 6080: 5842: 5838: 5673:Fanapanel (MPQX) 5433: 5429: 5409: 5402: 5395: 5386: 5385: 5315: 5314: 5258:Sodium valproate 5230: 5185: 5181: 5153: 5131: 5127: 5121: 5120: 5042: 5038: 4926: 4922: 4916: 4915: 4894: 4890: 4881: 4874: 4867: 4858: 4857: 4829:Nitrous oxide (N 4800: 4799: 4769:Gasotransmitters 4766: 4765: 4746: 4745: 4736: 4690: 4689: 4683: 4682: 4650: 4649: 4585:Anandamide (AEA) 4553:Endocannabinoids 4550: 4549: 4517: 4516: 4404:Serotonin (5-HT) 4369: 4368: 4188:Glutamate system 4185: 4184: 4176: 4175: 4155: 4148: 4141: 4132: 4131: 3946: 3945: 3317: 3316: 3173:(4th generation) 3140:(4th generation) 3081:(3rd generation) 3079:Aminopenicillins 3075: 3074: 3022:(2nd generation) 2962:(1st generation) 2955: 2954: 2944: 2943: 2930: 2929: 2925: 2917: 2913: 2899:of peptidoglycan 2895: 2860: 2853: 2846: 2837: 2836: 2560: 2559: 2478: 2477: 2323: 2322: 2290: 2283: 2276: 2267: 2266: 2260: 2259: 2257: 2256: 2247:. Archived from 2241: 2235: 2234: 2216: 2206: 2178: 2172: 2171: 2161: 2137: 2131: 2130: 2120: 2088: 2082: 2081: 2071: 2039: 2033: 2032: 2022: 2012: 1988: 1982: 1981: 1971: 1939: 1933: 1932: 1917: 1911: 1910: 1908: 1906: 1886: 1877: 1876: 1874: 1872: 1852: 1846: 1845: 1825: 1819: 1818: 1794: 1788: 1787: 1767: 1761: 1760: 1748: 1742: 1741: 1731: 1714:(6): 2603–2612. 1699: 1693: 1692: 1682: 1650: 1644: 1643: 1623: 1617: 1616: 1606: 1582: 1573: 1572: 1554: 1539:The FEBS Journal 1530: 1513: 1512: 1502: 1470: 1464: 1463: 1453: 1421: 1415: 1414: 1404: 1372: 1363: 1362: 1352: 1320: 1314: 1313: 1302: 1293: 1292: 1282: 1264: 1255: 1249: 1248: 1246: 1227: 1221: 1220: 1196: 1190: 1189: 1187: 1185: 1170: 1151: 1150: 1113: 1088: 1081:combination drug 1076: 1072: 1069:carryover effect 1064: 1060: 1053:exposure therapy 1048: 983: 982: 977: 976: 971: 970: 965: 964: 952: 951: 941: 940: 920: 896: 892: 888: 880: 876: 868: 864: 863:-alanine to the 860: 850: 846: 842:alanine racemase 827: 755:M. tuberculosis. 717: 661:, used to treat 640: 639: 570: 550: 535: 529: 523: 517: 500: 489: 478: 477: 463: 461: 446: 426: 406: 386: 366: 346: 326: 306: 296: 295: 281: 219: 171: 168: 146: 122: 111: 108: 95: 76: 75: 49: 40: 33: 31: 27: 8203: 8202: 8198: 8197: 8196: 8194: 8193: 8192: 8153: 8152: 8151: 8141: 8139: 8131: 8129: 8124: 8094: 8063: 8053: 8025: 8015: 7996:Hexachlorophene 7957: 7947: 7935: 7927: 7917: 7907: 7895: 7870: 7860: 7837: 7814: 7777:Reactive blue 2 7655: 7645: 7498: 7479: 7464: 7434: 7429: 7397: 7295:Flufenamic acid 7230:Trichloroethane 7005:Rhynchophylline 6925:Methoxphenidine 6890:Levomilnacipran 6790:Dextromethadone 6715:α-Endopsychosin 6319: 6231:Dimethylglycine 6141:Quinolinic acid 6082: 6072: 5910:Quisqualic acid 5840: 5830: 5486:Quisqualic acid 5431: 5421: 5413: 5383: 5378: 5365: 5331: 5302: 5248:Rosmarinic acid 5183: 5173: 5151: 5129: 5106: 5040: 5030: 4924: 4905: 4892: 4885: 4855: 4846: 4841: 4832: 4818: 4794: 4784: 4760: 4717: 4663: 4639: 4530: 4502: 4486: 4408: 4364:Biogenic amines 4354: 4331: 4280: 4254: 4180: 4164: 4159: 4129: 4124: 4123: 4108:Clinical trials 4087: 4039: 3985: 3968: 3931: 3835: 3808:Clavulanic acid 3775: 3738: 3710: 3692: 3664: 3631: 3496: 3403: 3310: 3306: 3302: 3294: 3252:Antipseudomonal 3220: 3194: 3165: 3132: 3069: 3058: 3021: 3013: 2961: 2949: 2922:transpeptidases 2921: 2911: 2906: 2904: 2902: 2900: 2898: 2896: 2894: 2886: 2864: 2834: 2829: 2828: 2813:Clinical trials 2792: 2756: 2676: 2615: 2596:Ethylenediamine 2587:Arabinogalactan 2581: 2545: 2527: 2504: 2482:Aminoglycosides 2463: 2444: 2435: 2407: 2360: 2330: 2312: 2294: 2264: 2263: 2254: 2252: 2243: 2242: 2238: 2195:Springer Nature 2179: 2175: 2138: 2134: 2089: 2085: 2040: 2036: 1989: 1985: 1940: 1936: 1919: 1918: 1914: 1904: 1902: 1887: 1880: 1870: 1868: 1853: 1849: 1826: 1822: 1795: 1791: 1768: 1764: 1749: 1745: 1700: 1696: 1651: 1647: 1624: 1620: 1583: 1576: 1531: 1516: 1471: 1467: 1422: 1418: 1373: 1366: 1335:(5): CD007803. 1321: 1317: 1304: 1303: 1296: 1262: 1256: 1252: 1228: 1224: 1213: 1197: 1193: 1183: 1181: 1172: 1171: 1154: 1114: 1110: 1105: 1055:in people with 1045: 1025: 997: 980: 979: 974: 973: 968: 967: 962: 961: 949: 948: 938: 937: 934: 912: 853:-alanine ligase 819: 811:Cochrane review 807: 750: 745: 735:. It is on the 635: 633: 628: 625: 620: 615: 614: 603: 600: 595: 594: 573: 548: 538: 532: 526: 520: 481: 457: 449: 429: 409: 389: 369: 349: 329: 309: 292: 284: 264: 261: 252: 251: 217: 194:Bioavailability 186:Pharmacokinetic 180: 150: 125: 73: 72: 24: 17: 12: 11: 5: 8201: 8191: 8190: 8185: 8180: 8175: 8170: 8165: 8150: 8149: 8126: 8125: 8103: 8100: 8099: 8096: 8095: 8093: 8092: 8087: 8079: 8074: 8068: 8066: 8055: 8054: 8052: 8051: 8046: 8041: 8036: 8030: 8028: 8017: 8016: 8014: 8013: 8008: 8003: 7998: 7993: 7988: 7983: 7978: 7973: 7968: 7962: 7960: 7949: 7948: 7946: 7945: 7940: 7932: 7922: 7920: 7909: 7908: 7906: 7905: 7900: 7891: 7886: 7881: 7875: 7873: 7862: 7861: 7859: 7858: 7853: 7848: 7842: 7840: 7826: 7820: 7819: 7816: 7815: 7813: 7812: 7807: 7802: 7797: 7789: 7784: 7779: 7774: 7769: 7764: 7759: 7757:Kynurenic acid 7754: 7749: 7744: 7739: 7737:-glutamic acid 7730: 7728:Direct blue 71 7725: 7720: 7715: 7710: 7705: 7700: 7698:Bafilomycin A1 7695: 7690: 7685: 7680: 7675: 7670: 7660: 7658: 7647: 7646: 7644: 7643: 7638: 7633: 7625: 7620: 7615: 7610: 7605: 7600: 7595: 7583: 7575: 7567: 7559: 7547: 7542: 7537: 7532: 7527: 7522: 7514: 7509: 7503: 7501: 7487: 7481: 7480: 7463: 7462: 7455: 7448: 7440: 7431: 7430: 7428: 7427: 7420: 7413: 7402: 7399: 7398: 7396: 7395: 7383: 7382: 7372: 7367: 7362: 7357: 7352: 7347: 7342: 7337: 7332: 7327: 7322: 7317: 7312: 7307: 7302: 7297: 7292: 7287: 7279: 7274: 7269: 7264: 7252: 7247: 7242: 7237: 7232: 7227: 7222: 7217: 7212: 7207: 7205:Methoxyflurane 7202: 7197: 7192: 7187: 7182: 7177: 7172: 7167: 7162: 7157: 7152: 7140: 7135: 7123: 7118: 7113: 7101: 7096: 7091: 7086: 7081: 7076: 7071: 7066: 7061: 7056: 7051: 7046: 7037: 7032: 7027: 7022: 7017: 7012: 7007: 7002: 6997: 6992: 6987: 6982: 6977: 6972: 6967: 6962: 6957: 6952: 6950:Nitromemantine 6947: 6942: 6937: 6932: 6927: 6922: 6917: 6912: 6907: 6902: 6897: 6892: 6887: 6885:Levomethorphan 6882: 6877: 6872: 6867: 6862: 6857: 6852: 6847: 6842: 6837: 6832: 6827: 6822: 6817: 6812: 6807: 6805:Dieticyclidine 6802: 6797: 6792: 6787: 6785:Dextrallorphan 6782: 6777: 6772: 6767: 6762: 6757: 6752: 6747: 6742: 6740:Argiotoxin-636 6737: 6732: 6727: 6722: 6717: 6712: 6707: 6702: 6697: 6692: 6687: 6682: 6677: 6665: 6660: 6655: 6653:Diaminopropane 6650: 6645: 6633: 6628: 6623: 6618: 6613: 6608: 6603: 6598: 6593: 6588: 6583: 6581:Kynurenic acid 6578: 6573: 6568: 6563: 6558: 6553: 6545: 6540: 6535: 6530: 6525: 6520: 6515: 6510: 6505: 6500: 6495: 6483: 6478: 6473: 6468: 6463: 6458: 6453: 6448: 6443: 6438: 6433: 6428: 6423: 6418: 6413: 6408: 6403: 6398: 6393: 6388: 6383: 6371: 6370: 6365: 6360: 6355: 6350: 6345: 6340: 6327: 6312: 6296: 6291: 6279: 6274: 6269: 6264: 6256: 6248: 6243: 6238: 6233: 6228: 6223: 6215: 6207: 6199: 6194: 6189: 6184: 6179: 6174: 6169: 6164: 6148: 6143: 6138: 6133: 6128: 6123: 6118: 6109: 6104: 6099: 6087: 6085: 6074: 6073: 6071: 6070: 6065: 6060: 6055: 6050: 6045: 6024: 6019: 6014: 6009: 6004: 5999: 5994: 5989: 5984: 5982:Kynurenic acid 5979: 5974: 5969: 5964: 5959: 5954: 5945: 5944: 5939: 5934: 5929: 5924: 5912: 5907: 5902: 5897: 5892: 5887: 5882: 5877: 5872: 5867: 5862: 5857: 5845: 5843: 5832: 5831: 5829: 5828: 5816: 5811: 5806: 5801: 5796: 5791: 5786: 5781: 5776: 5771: 5766: 5761: 5756: 5735: 5730: 5725: 5720: 5715: 5710: 5705: 5700: 5695: 5690: 5688:Kynurenic acid 5685: 5680: 5675: 5670: 5665: 5660: 5655: 5650: 5645: 5640: 5631: 5630: 5625: 5620: 5615: 5610: 5605: 5600: 5595: 5590: 5585: 5580: 5575: 5570: 5565: 5560: 5555: 5550: 5545: 5540: 5535: 5530: 5525: 5520: 5515: 5510: 5505: 5500: 5488: 5483: 5478: 5473: 5468: 5463: 5458: 5453: 5448: 5436: 5434: 5423: 5422: 5412: 5411: 5404: 5397: 5389: 5380: 5379: 5377: 5376: 5369: 5363: 5358: 5351: 5344: 5340: 5337: 5336: 5333: 5332: 5330: 5329: 5323: 5321: 5319:Antivitamin B6 5312: 5308: 5307: 5304: 5303: 5301: 5300: 5291: 5290: 5285: 5280: 5275: 5270: 5265: 5260: 5255: 5245: 5240: 5235: 5227: 5222: 5217: 5212: 5207: 5202: 5197: 5188: 5186: 5175: 5174: 5172: 5171: 5162: 5161: 5156: 5148: 5143: 5134: 5132: 5118: 5112: 5111: 5108: 5107: 5105: 5104: 5099: 5094: 5092:Nipecotic acid 5089: 5084: 5082:N-Butyric acid 5079: 5074: 5069: 5064: 5059: 5057:Bafilomycin A1 5054: 5045: 5043: 5032: 5031: 5029: 5028: 5023: 5018: 5013: 5008: 5003: 4998: 4993: 4991:Nipecotic acid 4988: 4983: 4978: 4973: 4968: 4963: 4958: 4953: 4948: 4943: 4938: 4929: 4927: 4913: 4907: 4906: 4884: 4883: 4876: 4869: 4861: 4852: 4851: 4848: 4847: 4845: 4844: 4839: 4835: 4830: 4826: 4821: 4816: 4812: 4806: 4804: 4796: 4795: 4793: 4792: 4787: 4782: 4778: 4772: 4770: 4762: 4761: 4759: 4758: 4752: 4750: 4743: 4739: 4738: 4734: 4727: 4726: 4723: 4722: 4719: 4718: 4716: 4715: 4710: 4705: 4699: 4697: 4687: 4680: 4673: 4672: 4669: 4668: 4665: 4664: 4662: 4661: 4653: 4647: 4641: 4640: 4638: 4637: 4632: 4627: 4622: 4617: 4612: 4607: 4602: 4597: 4592: 4587: 4582: 4577: 4572: 4567: 4562: 4556: 4554: 4547: 4540: 4539: 4536: 4535: 4532: 4531: 4529: 4528: 4520: 4514: 4508: 4507: 4504: 4503: 4501: 4500: 4494: 4492: 4488: 4487: 4485: 4484: 4476: 4468: 4463: 4458: 4456:Phenethylamine 4453: 4448: 4440: 4432: 4427: 4422: 4416: 4414: 4410: 4409: 4407: 4406: 4401: 4396: 4391: 4386: 4381: 4375: 4373: 4366: 4360: 4359: 4356: 4355: 4353: 4352: 4347: 4341: 4339: 4333: 4332: 4330: 4329: 4324: 4319: 4314: 4309: 4304: 4299: 4294: 4288: 4286: 4285:Glycine system 4282: 4281: 4279: 4278: 4273: 4268: 4262: 4260: 4256: 4255: 4253: 4252: 4247: 4242: 4237: 4232: 4230:Kynurenic acid 4227: 4222: 4217: 4212: 4207: 4202: 4197: 4191: 4189: 4182: 4173: 4166: 4165: 4158: 4157: 4150: 4143: 4135: 4126: 4125: 4122: 4121: 4120: 4119: 4116: 4105: 4099: 4093: 4092: 4089: 4088: 4086: 4085: 4080: 4075: 4074: 4073: 4068: 4058: 4057: 4056: 4047: 4045: 4041: 4040: 4038: 4037: 4027: 4013: 3997: 3995: 3991: 3990: 3987: 3986: 3984: 3983: 3976: 3974: 3970: 3969: 3967: 3966: 3961: 3954: 3952: 3943: 3937: 3936: 3933: 3932: 3930: 3929: 3924: 3919: 3914: 3909: 3904: 3899: 3894: 3889: 3884: 3879: 3874: 3869: 3864: 3854: 3849: 3843: 3841: 3837: 3836: 3834: 3833: 3827: 3822: 3817: 3813:non-β-lactam ( 3811: 3801: 3795: 3785: 3783: 3777: 3776: 3774: 3773: 3768: 3763: 3758: 3752: 3750: 3744: 3743: 3740: 3739: 3737: 3736: 3731: 3726: 3720: 3718: 3712: 3711: 3709: 3708: 3702: 3700: 3694: 3693: 3691: 3690: 3685: 3680: 3674: 3672: 3670:5th generation 3666: 3665: 3663: 3662: 3657: 3652: 3647: 3641: 3639: 3637:4th generation 3633: 3632: 3630: 3629: 3623: 3614: 3609: 3604: 3599: 3594: 3589: 3584: 3579: 3574: 3569: 3564: 3559: 3554: 3549: 3544: 3539: 3534: 3528: 3522: 3517: 3512: 3506: 3504: 3502:3rd generation 3498: 3497: 3495: 3494: 3484: 3478: 3473: 3468: 3463: 3454: 3449: 3444: 3439: 3434: 3429: 3424: 3419: 3413: 3411: 3409:2nd generation 3405: 3404: 3402: 3401: 3396: 3391: 3386: 3381: 3376: 3371: 3366: 3361: 3356: 3351: 3346: 3341: 3336: 3331: 3325: 3323: 3321:1st generation 3314: 3304:Cephalosporins 3296: 3295: 3293: 3292: 3286: 3280: 3274: 3269: 3263: 3258: 3249: 3242: 3240: 3230: 3229: 3226: 3225: 3222: 3221: 3219: 3218: 3213: 3202: 3200: 3196: 3195: 3193: 3192: 3187: 3182: 3176: 3174: 3167: 3166: 3164: 3163: 3158: 3149: 3143: 3141: 3134: 3133: 3131: 3130: 3125: 3119: 3114: 3109: 3104: 3099: 3090: 3084: 3082: 3072: 3064: 3063: 3060: 3059: 3057: 3056: 3051: 3046: 3041: 3038:Flucloxacillin 3035: 3025: 3023: 3015: 3014: 3012: 3011: 3006: 3001: 2996: 2991: 2986: 2981: 2976: 2971: 2965: 2963: 2952: 2941: 2927: 2888: 2887: 2869:active on the 2867:Antibacterials 2863: 2862: 2855: 2848: 2840: 2831: 2830: 2827: 2826: 2825: 2824: 2821: 2810: 2804: 2798: 2797: 2794: 2793: 2791: 2790: 2785: 2780: 2775: 2770: 2764: 2762: 2758: 2757: 2755: 2754: 2738:Nitroimidazole 2734: 2729: 2717: 2701: 2688: 2686: 2682: 2681: 2678: 2677: 2675: 2674: 2667: 2666: 2661: 2656: 2650:Thiocarbamides 2646: 2645: 2640: 2626: 2624: 2617: 2616: 2614: 2613: 2607: 2606: 2592: 2590: 2583: 2582: 2580: 2579: 2569: 2567: 2557: 2551: 2550: 2547: 2546: 2544: 2543: 2537: 2535: 2529: 2528: 2526: 2525: 2520: 2514: 2512: 2506: 2505: 2503: 2502: 2497: 2492: 2486: 2484: 2475: 2469: 2468: 2465: 2464: 2462: 2461: 2456: 2450: 2448: 2437: 2436: 2434: 2433: 2427: 2415: 2413: 2409: 2408: 2406: 2405: 2400: 2395: 2390: 2385: 2380: 2374: 2372: 2362: 2361: 2359: 2358: 2353: 2348: 2343: 2337: 2335: 2332:RNA polymerase 2320: 2314: 2313: 2293: 2292: 2285: 2278: 2270: 2262: 2261: 2236: 2173: 2152:(6): 737–738. 2132: 2083: 2034: 1983: 1934: 1912: 1878: 1847: 1820: 1789: 1762: 1757:Google Patents 1743: 1694: 1665:(3): 147–154. 1645: 1618: 1574: 1545:(4): 1150–66. 1514: 1465: 1436:(11): 947–55. 1416: 1364: 1315: 1294: 1250: 1222: 1211: 1191: 1152: 1107: 1106: 1104: 1101: 1044: 1041: 1024: 1021: 996: 993: 933: 930: 911: 908: 885:dipeptide bond 818: 815: 806: 803: 749: 746: 744: 741: 694:kidney failure 642: 641: 630: 629: 627: 626: 623: 621: 618: 610: 609: 608: 605: 604: 602: 601: 598: 590: 589: 588: 585: 584: 581: 575: 574: 572: 571: 563: 561: 553: 552: 546: 540: 539: 536: 530: 524: 518: 513: 507: 506: 502: 501: 491: 483: 482: 480: 479: 466: 464: 451: 450: 448: 447: 439: 437: 431: 430: 428: 427: 419: 417: 411: 410: 408: 407: 399: 397: 391: 390: 388: 387: 379: 377: 371: 370: 368: 367: 359: 357: 351: 350: 348: 347: 339: 337: 331: 330: 328: 327: 319: 317: 311: 310: 308: 307: 299: 297: 286: 285: 283: 282: 274: 272: 266: 265: 263: 262: 255: 247: 246: 245: 242: 241: 237: 236: 231: 225: 224: 221: 212: 211: 206: 200: 199: 196: 190: 189: 182: 181: 179: 178: 165: 163: 157: 156: 152: 151: 149: 148: 135: 133: 127: 126: 124: 123: 105: 103: 97: 96: 89: 79: 78: 70: 66: 65: 62: 56: 55: 51: 50: 42: 41: 15: 9: 6: 4: 3: 2: 8200: 8189: 8186: 8184: 8181: 8179: 8176: 8174: 8171: 8169: 8166: 8164: 8161: 8160: 8158: 8148: 8138: 8137: 8134: 8123: 8122: 8118: 8114: 8110: 8107: 8101: 8091: 8090:Semicarbazide 8088: 8086: 8085:-Allylglycine 8080: 8078: 8075: 8073: 8070: 8069: 8067: 8062: 8056: 8050: 8047: 8045: 8042: 8040: 8037: 8035: 8032: 8031: 8029: 8024: 8018: 8012: 8009: 8007: 8006:Palmitoyl-CoA 8004: 8002: 8001:Hydroxylamine 7999: 7997: 7994: 7992: 7989: 7987: 7984: 7982: 7979: 7977: 7974: 7972: 7969: 7967: 7964: 7963: 7961: 7956: 7950: 7944: 7941: 7939: 7933: 7931: 7924: 7923: 7921: 7916: 7910: 7904: 7901: 7899: 7892: 7890: 7887: 7885: 7882: 7880: 7877: 7876: 7874: 7869: 7863: 7857: 7854: 7852: 7849: 7847: 7844: 7843: 7841: 7836: 7830: 7827: 7825: 7821: 7811: 7808: 7806: 7803: 7801: 7798: 7796: 7794: 7790: 7788: 7785: 7783: 7780: 7778: 7775: 7773: 7770: 7768: 7765: 7763: 7760: 7758: 7755: 7753: 7750: 7748: 7745: 7743: 7740: 7738: 7731: 7729: 7726: 7724: 7721: 7719: 7716: 7714: 7711: 7709: 7706: 7704: 7701: 7699: 7696: 7694: 7691: 7689: 7686: 7684: 7681: 7679: 7676: 7674: 7671: 7669: 7662: 7661: 7659: 7654: 7648: 7642: 7639: 7637: 7634: 7632: 7630: 7626: 7624: 7621: 7619: 7616: 7614: 7611: 7609: 7606: 7604: 7603:Maslinic acid 7601: 7599: 7596: 7594: 7592: 7584: 7582: 7576: 7574: 7568: 7566: 7560: 7558: 7556: 7548: 7546: 7543: 7541: 7538: 7536: 7533: 7531: 7528: 7526: 7523: 7521: 7519: 7515: 7513: 7510: 7508: 7505: 7504: 7502: 7497: 7491: 7488: 7486: 7482: 7478: 7475: 7471: 7468: 7461: 7456: 7454: 7449: 7447: 7442: 7441: 7438: 7426: 7425: 7421: 7419: 7418: 7414: 7412: 7411: 7408: 7404: 7403: 7400: 7394: 7391: 7388: 7385: 7384: 7380: 7376: 7375:Transcrocetin 7373: 7371: 7370:Psychotridine 7368: 7366: 7363: 7361: 7358: 7356: 7353: 7351: 7350:Niflumic acid 7348: 7346: 7343: 7341: 7338: 7336: 7333: 7331: 7328: 7326: 7323: 7321: 7318: 7316: 7313: 7311: 7308: 7306: 7303: 7301: 7298: 7296: 7293: 7291: 7288: 7286: 7280: 7278: 7275: 7273: 7270: 7268: 7265: 7263: 7260: 7256: 7253: 7251: 7248: 7246: 7243: 7241: 7238: 7236: 7233: 7231: 7228: 7226: 7223: 7221: 7218: 7216: 7213: 7211: 7210:Nitrous oxide 7208: 7206: 7203: 7201: 7198: 7196: 7193: 7191: 7188: 7186: 7183: 7181: 7178: 7176: 7175:Diethyl ether 7173: 7171: 7168: 7166: 7163: 7161: 7158: 7156: 7153: 7151: 7148: 7144: 7141: 7139: 7136: 7134: 7131: 7127: 7124: 7122: 7119: 7117: 7114: 7112: 7109: 7105: 7102: 7100: 7097: 7095: 7092: 7090: 7087: 7085: 7082: 7080: 7077: 7075: 7072: 7070: 7067: 7065: 7062: 7060: 7057: 7055: 7052: 7050: 7047: 7045: 7041: 7038: 7036: 7033: 7031: 7030:Tenocyclidine 7028: 7026: 7025:Tabernanthine 7023: 7021: 7018: 7016: 7015:Rolicyclidine 7013: 7011: 7008: 7006: 7003: 7001: 6998: 6996: 6993: 6991: 6990:Phencyclidine 6988: 6986: 6985:Phencyclamine 6983: 6981: 6978: 6976: 6973: 6971: 6968: 6966: 6963: 6961: 6958: 6956: 6953: 6951: 6948: 6946: 6943: 6941: 6938: 6936: 6933: 6931: 6928: 6926: 6923: 6921: 6920:Methoxetamine 6918: 6916: 6913: 6911: 6908: 6906: 6903: 6901: 6898: 6896: 6893: 6891: 6888: 6886: 6883: 6881: 6880:Levomethadone 6878: 6876: 6873: 6871: 6868: 6866: 6863: 6861: 6858: 6856: 6853: 6851: 6848: 6846: 6843: 6841: 6840:Fluorolintane 6838: 6836: 6833: 6831: 6828: 6826: 6823: 6821: 6818: 6816: 6813: 6811: 6808: 6806: 6803: 6801: 6798: 6796: 6793: 6791: 6788: 6786: 6783: 6781: 6778: 6776: 6773: 6771: 6768: 6766: 6763: 6761: 6758: 6756: 6753: 6751: 6748: 6746: 6743: 6741: 6738: 6736: 6733: 6731: 6728: 6726: 6723: 6721: 6718: 6716: 6713: 6711: 6708: 6706: 6703: 6701: 6698: 6696: 6693: 6691: 6688: 6686: 6683: 6681: 6678: 6676: 6673: 6669: 6666: 6664: 6661: 6659: 6656: 6654: 6651: 6649: 6646: 6644: 6641: 6637: 6634: 6632: 6629: 6627: 6624: 6622: 6619: 6617: 6614: 6612: 6609: 6607: 6604: 6602: 6599: 6597: 6594: 6592: 6589: 6587: 6584: 6582: 6579: 6577: 6574: 6572: 6569: 6567: 6564: 6562: 6559: 6557: 6554: 6552: 6546: 6544: 6541: 6539: 6536: 6534: 6531: 6529: 6526: 6524: 6521: 6519: 6516: 6514: 6511: 6509: 6506: 6504: 6501: 6499: 6496: 6494: 6491: 6487: 6484: 6482: 6479: 6477: 6474: 6472: 6469: 6467: 6464: 6462: 6459: 6457: 6454: 6452: 6449: 6447: 6444: 6442: 6439: 6437: 6434: 6432: 6429: 6427: 6424: 6422: 6421:Kaitocephalin 6419: 6417: 6414: 6412: 6409: 6407: 6404: 6402: 6399: 6397: 6394: 6392: 6389: 6387: 6384: 6382: 6379: 6376: 6373: 6372: 6369: 6366: 6364: 6361: 6359: 6356: 6354: 6351: 6349: 6346: 6344: 6341: 6338: 6334: 6328: 6325: 6318: 6313: 6311: 6309: 6304: 6300: 6297: 6295: 6292: 6290: 6287: 6283: 6280: 6278: 6275: 6273: 6270: 6268: 6265: 6263: 6257: 6255: 6249: 6247: 6244: 6242: 6239: 6237: 6234: 6232: 6229: 6227: 6224: 6222: 6216: 6214: 6208: 6206: 6200: 6198: 6195: 6193: 6190: 6188: 6185: 6183: 6180: 6178: 6175: 6173: 6170: 6168: 6165: 6163: 6156: 6152: 6149: 6147: 6144: 6142: 6139: 6137: 6134: 6132: 6129: 6127: 6126:Ibotenic acid 6124: 6122: 6119: 6117: 6110: 6108: 6105: 6103: 6100: 6098: 6095: 6092: 6089: 6088: 6086: 6081: 6075: 6069: 6066: 6064: 6061: 6059: 6056: 6054: 6051: 6049: 6046: 6043: 6039: 6038:pentobarbital 6035: 6032: 6028: 6025: 6023: 6020: 6018: 6015: 6013: 6010: 6008: 6005: 6003: 6000: 5998: 5995: 5993: 5990: 5988: 5985: 5983: 5980: 5978: 5977:Kaitocephalin 5975: 5973: 5970: 5968: 5965: 5963: 5960: 5958: 5955: 5953: 5950: 5947: 5946: 5943: 5940: 5938: 5935: 5933: 5930: 5928: 5925: 5923: 5922:Cyclothiazide 5920: 5916: 5913: 5911: 5908: 5906: 5903: 5901: 5898: 5896: 5893: 5891: 5890:Ibotenic acid 5888: 5886: 5883: 5881: 5878: 5876: 5873: 5871: 5868: 5866: 5863: 5861: 5858: 5856: 5853: 5850: 5847: 5846: 5844: 5839: 5833: 5827: 5824: 5820: 5817: 5815: 5812: 5810: 5807: 5805: 5802: 5800: 5797: 5795: 5792: 5790: 5787: 5785: 5782: 5780: 5777: 5775: 5772: 5770: 5767: 5765: 5762: 5760: 5757: 5754: 5750: 5749:pentobarbital 5746: 5743: 5739: 5736: 5734: 5731: 5729: 5726: 5724: 5721: 5719: 5716: 5714: 5711: 5709: 5706: 5704: 5701: 5699: 5696: 5694: 5691: 5689: 5686: 5684: 5683:Kaitocephalin 5681: 5679: 5676: 5674: 5671: 5669: 5666: 5664: 5661: 5659: 5656: 5654: 5651: 5649: 5646: 5644: 5641: 5639: 5636: 5633: 5632: 5629: 5626: 5624: 5621: 5619: 5616: 5614: 5611: 5609: 5606: 5604: 5601: 5599: 5596: 5594: 5591: 5589: 5586: 5584: 5581: 5579: 5576: 5574: 5571: 5569: 5566: 5564: 5561: 5559: 5556: 5554: 5551: 5549: 5546: 5544: 5541: 5539: 5536: 5534: 5531: 5529: 5526: 5524: 5521: 5519: 5516: 5514: 5511: 5509: 5506: 5504: 5503:Cyclothiazide 5501: 5499: 5496: 5492: 5489: 5487: 5484: 5482: 5479: 5477: 5476:Ibotenic acid 5474: 5472: 5469: 5467: 5464: 5462: 5459: 5457: 5454: 5452: 5449: 5447: 5444: 5441: 5438: 5437: 5435: 5430: 5424: 5420: 5417: 5410: 5405: 5403: 5398: 5396: 5391: 5390: 5387: 5375: 5374: 5370: 5368: 5367: 5359: 5357: 5356: 5352: 5350: 5349: 5345: 5342: 5341: 5338: 5328: 5325: 5324: 5322: 5320: 5316: 5313: 5309: 5299: 5298:3-Methyl-GABA 5296: 5293: 5292: 5289: 5286: 5284: 5281: 5279: 5278:Valproic acid 5276: 5274: 5271: 5269: 5266: 5264: 5261: 5259: 5256: 5253: 5249: 5246: 5244: 5241: 5239: 5236: 5234: 5228: 5226: 5223: 5221: 5218: 5216: 5213: 5211: 5208: 5206: 5203: 5201: 5198: 5196: 5193: 5190: 5189: 5187: 5182: 5176: 5170: 5169:3-Methyl-GABA 5167: 5164: 5163: 5160: 5159:Semicarbazide 5157: 5155: 5154:-Allylglycine 5149: 5147: 5144: 5142: 5139: 5136: 5135: 5133: 5128: 5122: 5119: 5117: 5113: 5103: 5100: 5098: 5095: 5093: 5090: 5088: 5085: 5083: 5080: 5078: 5075: 5073: 5070: 5068: 5065: 5063: 5060: 5058: 5055: 5053: 5050: 5047: 5046: 5044: 5039: 5033: 5027: 5024: 5022: 5019: 5017: 5014: 5012: 5009: 5007: 5004: 5002: 4999: 4997: 4994: 4992: 4989: 4987: 4984: 4982: 4981:Ibotenic acid 4979: 4977: 4974: 4972: 4969: 4967: 4964: 4962: 4959: 4957: 4954: 4952: 4949: 4947: 4944: 4942: 4939: 4937: 4934: 4931: 4930: 4928: 4923: 4917: 4914: 4912: 4908: 4904: 4901: 4897: 4891: 4882: 4877: 4875: 4870: 4868: 4863: 4862: 4859: 4843: 4836: 4834: 4827: 4825: 4822: 4820: 4813: 4811: 4808: 4807: 4805: 4801: 4791: 4788: 4786: 4779: 4777: 4774: 4773: 4771: 4767: 4757: 4756:Acetylcholine 4754: 4753: 4751: 4747: 4744: 4742:Miscellaneous 4740: 4735: 4732: 4728: 4714: 4711: 4709: 4706: 4704: 4701: 4700: 4698: 4695: 4691: 4688: 4684: 4681: 4678: 4674: 4659: 4655: 4654: 4651: 4648: 4646: 4645:Neurosteroids 4642: 4636: 4633: 4631: 4628: 4626: 4623: 4621: 4618: 4616: 4613: 4611: 4608: 4606: 4603: 4601: 4598: 4596: 4593: 4591: 4588: 4586: 4583: 4581: 4578: 4576: 4573: 4571: 4568: 4566: 4563: 4561: 4558: 4557: 4555: 4551: 4548: 4545: 4541: 4526: 4522: 4521: 4518: 4515: 4513: 4512:Neuropeptides 4509: 4499: 4496: 4495: 4493: 4489: 4483: 4481: 4477: 4475: 4473: 4469: 4467: 4464: 4462: 4459: 4457: 4454: 4452: 4449: 4447: 4445: 4441: 4439: 4437: 4433: 4431: 4428: 4426: 4423: 4421: 4418: 4417: 4415: 4411: 4405: 4402: 4400: 4397: 4395: 4392: 4390: 4387: 4385: 4382: 4380: 4377: 4376: 4374: 4370: 4367: 4365: 4361: 4351: 4348: 4346: 4343: 4342: 4340: 4338: 4334: 4328: 4325: 4323: 4320: 4318: 4315: 4313: 4310: 4308: 4305: 4303: 4300: 4298: 4295: 4293: 4290: 4289: 4287: 4283: 4277: 4274: 4272: 4269: 4267: 4264: 4263: 4261: 4257: 4251: 4248: 4246: 4243: 4241: 4238: 4236: 4233: 4231: 4228: 4226: 4223: 4221: 4218: 4216: 4213: 4211: 4208: 4206: 4203: 4201: 4198: 4196: 4193: 4192: 4190: 4186: 4183: 4177: 4174: 4171: 4167: 4163: 4156: 4151: 4149: 4144: 4142: 4137: 4136: 4133: 4117: 4115: 4112: 4111: 4109: 4106: 4103: 4100: 4098: 4095: 4094: 4090: 4084: 4081: 4079: 4076: 4072: 4069: 4067: 4064: 4063: 4062: 4059: 4055: 4052: 4051: 4049: 4048: 4046: 4042: 4035: 4031: 4028: 4025: 4021: 4017: 4014: 4011: 4007: 4003: 3999: 3998: 3996: 3994:Intracellular 3992: 3982: 3978: 3977: 3975: 3971: 3965: 3962: 3960: 3956: 3955: 3953: 3951: 3947: 3944: 3942: 3938: 3928: 3925: 3923: 3920: 3918: 3915: 3913: 3910: 3908: 3905: 3903: 3900: 3898: 3895: 3893: 3890: 3888: 3885: 3883: 3880: 3878: 3875: 3873: 3870: 3868: 3865: 3862: 3861:Sultamicillin 3858: 3855: 3853: 3850: 3848: 3845: 3844: 3842: 3838: 3831: 3828: 3826: 3823: 3821: 3818: 3816: 3812: 3809: 3805: 3802: 3799: 3796: 3794: 3790: 3787: 3786: 3784: 3782: 3778: 3772: 3769: 3767: 3764: 3762: 3759: 3757: 3754: 3753: 3751: 3749: 3745: 3735: 3732: 3730: 3727: 3725: 3722: 3721: 3719: 3717: 3713: 3707: 3704: 3703: 3701: 3699: 3695: 3689: 3686: 3684: 3681: 3679: 3676: 3675: 3673: 3671: 3667: 3661: 3658: 3656: 3653: 3651: 3648: 3646: 3643: 3642: 3640: 3638: 3634: 3627: 3624: 3622: 3618: 3615: 3613: 3610: 3608: 3605: 3603: 3600: 3598: 3595: 3593: 3590: 3588: 3585: 3583: 3580: 3578: 3575: 3573: 3570: 3568: 3565: 3563: 3560: 3558: 3555: 3553: 3550: 3548: 3545: 3543: 3540: 3538: 3535: 3532: 3529: 3527: 3523: 3521: 3518: 3516: 3513: 3511: 3508: 3507: 3505: 3503: 3499: 3492: 3488: 3485: 3482: 3479: 3477: 3476:Cefbuperazone 3474: 3472: 3469: 3467: 3464: 3462: 3458: 3455: 3453: 3450: 3448: 3445: 3443: 3440: 3438: 3435: 3433: 3430: 3428: 3425: 3423: 3420: 3418: 3415: 3414: 3412: 3410: 3406: 3400: 3397: 3395: 3392: 3390: 3387: 3385: 3382: 3380: 3377: 3375: 3372: 3370: 3367: 3365: 3362: 3360: 3357: 3355: 3352: 3350: 3347: 3345: 3342: 3340: 3337: 3335: 3332: 3330: 3327: 3326: 3324: 3322: 3318: 3315: 3313: 3309: 3305: 3301: 3297: 3290: 3287: 3285: 3281: 3278: 3275: 3273: 3270: 3267: 3264: 3262: 3259: 3257: 3253: 3250: 3248: 3245:Carbapenems ( 3244: 3243: 3241: 3239: 3235: 3231: 3217: 3216:Sulbenicillin 3214: 3211: 3210:Pivmecillinam 3207: 3204: 3203: 3201: 3197: 3191: 3188: 3186: 3183: 3181: 3178: 3177: 3175: 3172: 3168: 3162: 3159: 3157: 3156:Carindacillin 3153: 3152:Carbenicillin 3150: 3148: 3145: 3144: 3142: 3139: 3135: 3129: 3126: 3123: 3122:Talampicillin 3120: 3118: 3117:Metampicillin 3115: 3113: 3112:Lenampicillin 3110: 3108: 3107:Bacampicillin 3105: 3103: 3100: 3098: 3097:Pivampicillin 3094: 3091: 3089: 3086: 3085: 3083: 3080: 3076: 3073: 3071: 3065: 3055: 3052: 3050: 3047: 3045: 3042: 3039: 3036: 3034: 3033:Dicloxacillin 3030: 3027: 3026: 3024: 3020: 3016: 3010: 3007: 3005: 3004:Clometocillin 3002: 3000: 2997: 2995: 2994:Pheneticillin 2992: 2990: 2987: 2985: 2982: 2980: 2977: 2975: 2972: 2970: 2967: 2966: 2964: 2960: 2956: 2953: 2951: 2945: 2942: 2939: 2935: 2931: 2928: 2923: 2909: 2893: 2889: 2884: 2880: 2876: 2872: 2868: 2861: 2856: 2854: 2849: 2847: 2842: 2841: 2838: 2822: 2820: 2817: 2816: 2814: 2811: 2808: 2805: 2803: 2800: 2799: 2795: 2789: 2786: 2784: 2781: 2779: 2776: 2774: 2771: 2769: 2766: 2765: 2763: 2759: 2752: 2751: 2746: 2745: 2740: 2739: 2735: 2733: 2730: 2727: 2723: 2722: 2718: 2715: 2711: 2707: 2706: 2702: 2699: 2695: 2694: 2690: 2689: 2687: 2685:Other/unknown 2683: 2673: 2669: 2668: 2665: 2662: 2660: 2659:Prothionamide 2657: 2655: 2651: 2648: 2647: 2644: 2641: 2639: 2635: 2631: 2628: 2627: 2625: 2622: 2618: 2612: 2609: 2608: 2605: 2601: 2597: 2594: 2593: 2591: 2588: 2584: 2578: 2574: 2571: 2570: 2568: 2565: 2564:Peptidoglycan 2561: 2558: 2556: 2552: 2542: 2539: 2538: 2536: 2534: 2530: 2524: 2521: 2519: 2516: 2515: 2513: 2511: 2507: 2501: 2498: 2496: 2493: 2491: 2488: 2487: 2485: 2483: 2479: 2476: 2474: 2470: 2460: 2457: 2455: 2452: 2451: 2449: 2447: 2442: 2438: 2431: 2428: 2426: 2422: 2421: 2417: 2416: 2414: 2410: 2404: 2401: 2399: 2396: 2394: 2391: 2389: 2386: 2384: 2381: 2379: 2376: 2375: 2373: 2371: 2367: 2363: 2357: 2354: 2352: 2349: 2347: 2344: 2342: 2339: 2338: 2336: 2333: 2328: 2324: 2321: 2319: 2315: 2310: 2306: 2302: 2298: 2291: 2286: 2284: 2279: 2277: 2272: 2271: 2268: 2251:on 2020-07-09 2250: 2246: 2240: 2232: 2228: 2224: 2220: 2215: 2210: 2205: 2200: 2196: 2192: 2188: 2184: 2177: 2169: 2165: 2160: 2155: 2151: 2147: 2143: 2136: 2128: 2124: 2119: 2114: 2110: 2106: 2103:(5): 936–41. 2102: 2098: 2094: 2087: 2079: 2075: 2070: 2065: 2061: 2057: 2053: 2049: 2045: 2038: 2030: 2026: 2021: 2016: 2011: 2006: 2002: 1998: 1994: 1987: 1979: 1975: 1970: 1965: 1961: 1957: 1954:(5): E15-27. 1953: 1949: 1945: 1938: 1930: 1926: 1922: 1916: 1900: 1896: 1892: 1885: 1883: 1866: 1862: 1858: 1851: 1843: 1839: 1836:(8): 2345–6. 1835: 1831: 1824: 1816: 1812: 1809:(8): 2346–7. 1808: 1804: 1800: 1793: 1785: 1781: 1778:(8): 2344–5. 1777: 1773: 1766: 1758: 1754: 1747: 1739: 1735: 1730: 1725: 1721: 1717: 1713: 1709: 1705: 1698: 1690: 1686: 1681: 1676: 1672: 1668: 1664: 1660: 1656: 1649: 1641: 1637: 1633: 1629: 1622: 1614: 1610: 1605: 1600: 1597:(5): 253–60. 1596: 1592: 1588: 1581: 1579: 1570: 1566: 1562: 1558: 1553: 1548: 1544: 1540: 1536: 1529: 1527: 1525: 1523: 1521: 1519: 1510: 1506: 1501: 1496: 1492: 1488: 1485:(3): 978–87. 1484: 1480: 1476: 1469: 1461: 1457: 1452: 1447: 1443: 1439: 1435: 1431: 1427: 1420: 1412: 1408: 1403: 1398: 1394: 1390: 1387:(4): pyv102. 1386: 1382: 1378: 1371: 1369: 1360: 1356: 1351: 1346: 1342: 1338: 1334: 1330: 1326: 1319: 1311: 1307: 1301: 1299: 1290: 1286: 1281: 1276: 1273:(8): 1573–8. 1272: 1268: 1261: 1254: 1245: 1240: 1236: 1232: 1226: 1218: 1214: 1212:9783642460517 1208: 1204: 1203: 1195: 1179: 1175: 1174:"Cycloserine" 1169: 1167: 1165: 1163: 1161: 1159: 1157: 1148: 1144: 1140: 1136: 1132: 1128: 1124: 1120: 1112: 1108: 1100: 1098: 1094: 1087:, containing 1086: 1082: 1070: 1058: 1054: 1040: 1037: 1035: 1029: 1020: 1018: 1017:hydroxylamine 1014: 1010: 1006: 1002: 992: 989: 987: 958: 956: 945: 929: 926: 924: 917: 916:hydroxylamine 907: 905: 904:NMDA receptor 900: 886: 874: 858: 854: 843: 839: 838:peptidoglycan 835: 831: 824: 814: 812: 802: 800: 796: 792: 788: 784: 780: 776: 772: 768: 765:, confusion, 764: 761:, dizziness, 760: 756: 740: 738: 734: 733: 727: 725: 721: 715: 711: 707: 703: 699: 695: 691: 687: 683: 679: 674: 672: 669:, for active 668: 664: 660: 656: 652: 648: 638: 631: 622: 617: 616: 613: 606: 597: 596: 593: 586: 582: 580: 579:Melting point 576: 569: 565: 564: 562: 559: 554: 547: 545: 541: 514: 512: 508: 503: 499: 495: 492: 490: 488:ECHA InfoCard 484: 476: 472: 471:DTXSID8022870 468: 467: 465: 456: 452: 445: 441: 440: 438: 436: 432: 425: 421: 420: 418: 416: 412: 405: 401: 400: 398: 396: 392: 385: 381: 380: 378: 376: 372: 365: 361: 360: 358: 356: 352: 345: 341: 340: 338: 336: 332: 325: 321: 320: 318: 316: 312: 305: 301: 300: 298: 291: 287: 280: 276: 275: 273: 271: 267: 259: 254: 253: 250: 243: 238: 235: 232: 230: 226: 222: 220: 213: 210: 207: 205: 201: 197: 195: 191: 187: 183: 177: 167: 166: 164: 162: 158: 153: 145: 140: 137: 136: 134: 132: 128: 121: 116: 107: 106: 104: 102: 98: 94: 90: 88: 84: 80: 71: 67: 63: 61: 57: 54:Clinical data 52: 48: 43: 39: 34: 26: 22: 8105: 8104: 7938:-Cycloserine 7792: 7688:Acid red 114 7664:4-Methylene- 7628: 7590: 7554: 7517: 7422: 7415: 7406: 7405: 7389: 7386: 7258: 7165:Cyclopropane 7146: 7129: 7107: 7043: 6995:Propoxyphene 6965:Orphenadrine 6870:Ketobemidone 6835:Eticyclidine 6770:Coronaridine 6755:ARL-15896-AR 6671: 6639: 6551:-Cycloserine 6547: 6533:Carisoprodol 6489: 6377: 6375:Antagonists: 6374: 6307: 6302: 6285: 6213:-Cycloserine 6209: 6154: 6093: 6090: 6034:Barbiturates 6030: 6007:Selurampanel 5962:Dasolampanel 5949:Antagonists: 5948: 5918: 5851: 5848: 5822: 5759:Cyclopropane 5745:Barbiturates 5741: 5713:Selurampanel 5663:Dasolampanel 5635:Antagonists: 5634: 5618:Pramiracetam 5494: 5442: 5439: 5371: 5360: 5353: 5346: 5294: 5263:Valnoctamide 5233:-Cycloserine 5191: 5165: 5137: 5048: 4932: 4810:Acetaldehyde 4479: 4471: 4443: 4435: 4413:Trace amines 4032:inhibitors ( 4023: 4022:inhibitors ( 3950:Lipopeptides 3941:Polypeptides 3840:Combinations 3771:Nocardicin A 3688:Ceftobiprole 3531:Cefoperazone 3389:Cefaloridine 3374:Cefaloglycin 3312:Carbacephems 3180:Piperacillin 3009:Penamecillin 2910:, a group of 2761:Combinations 2748: 2742: 2736: 2719: 2710:Pyrazinamide 2703: 2691: 2643:Methaniazide 2634:mycolic acid 2621:Mycolic acid 2576: 2500:Streptomycin 2459:Moxifloxacin 2454:Gatifloxacin 2418: 2299:, including 2253:. Retrieved 2249:the original 2239: 2190: 2186: 2176: 2149: 2145: 2135: 2100: 2096: 2086: 2051: 2047: 2037: 2000: 1996: 1986: 1951: 1947: 1937: 1924: 1915: 1905:24 September 1903:. Retrieved 1894: 1871:21 September 1869:. Retrieved 1860: 1850: 1833: 1829: 1823: 1806: 1802: 1792: 1775: 1771: 1765: 1756: 1746: 1711: 1707: 1697: 1662: 1658: 1648: 1631: 1627: 1621: 1594: 1590: 1542: 1538: 1482: 1478: 1468: 1433: 1429: 1419: 1384: 1380: 1332: 1328: 1318: 1270: 1266: 1253: 1244:10665/325771 1234: 1225: 1201: 1194: 1182:. Retrieved 1122: 1118: 1111: 1046: 1038: 1030: 1026: 1012: 1005:Streptomyces 1004: 998: 990: 985: 966:-serine and 959: 943: 935: 927: 913: 901: 823:biosynthesis 820: 808: 767:paresthesias 754: 751: 748:Tuberculosis 743:Medical uses 732:Streptomyces 730: 728: 675: 663:tuberculosis 650: 646: 645: 634:   435:NIAID ChemDB 257: 216:Elimination 161:Legal status 155:Legal status 101:License data 25: 7976:Chloroquine 7805:Valinomycin 7800:Trypan blue 7782:Rose bengal 7767:NPPB (N144) 7641:WAY-213,613 7545:Kainic acid 7507:Amphetamine 7485:Transporter 7355:Pentamidine 7340:Minocycline 7320:Hodgkinsine 7290:Dexanabinol 7220:Sevoflurane 7074:Isoxsuprine 7069:Haloperidol 7049:Besonprodil 7010:Rimantadine 6960:Norketamine 6955:Noribogaine 6930:Milnacipran 6895:Levorphanol 6845:Gacyclidine 6815:Dizocilpine 6810:Diphenidine 6800:Dextrorphan 6720:Alaproclate 6663:Huperzine A 6616:Meprobamate 6576:Harkoseride 6471:Perzinfotel 6348:Plazinemdor 5895:Kainic acid 5880:Domoic acid 5826:Minocycline 5814:Sevoflurane 5491:Willardiine 5466:Domoic acid 5327:Ginkgotoxin 5295:Activators: 5192:Inhibitors: 5166:Activators: 5138:Inhibitors: 5097:Valinomycin 5049:Inhibitors: 4996:NNC 05-2090 4933:Inhibitors: 4911:Transporter 4815:Ammonia (NH 4686:Nucleosides 4446:-Octopamine 4438:-Octopamine 4350:T-HCA (GHC) 4307:Hypotaurine 4259:GABA system 4210:Glutathione 4104:from market 4083:Teixobactin 4061:Tyrothricin 4030:bactoprenol 4024:Cycloserine 3830:Vaborbactam 3820:Durlobactam 3748:Monobactams 3706:Cefiderocol 3698:Siderophore 3683:Ceftolozane 3597:Cefpimizole 3567:Cefpodoxime 3562:Cefpiramide 3557:Cefmenoxime 3552:Ceftizoxime 3547:Cefdaloxime 3526:Ceftazidime 3515:Ceftriaxone 3487:Carbacephem 3481:Cefmetazole 3437:Cefamandole 3399:Cefatrizine 3379:Cefacetrile 3364:Cefroxadine 3308:Cephamycins 3234:Carbapenems 3190:Mezlocillin 3147:Ticarcillin 3088:Amoxicillin 3054:Methicillin 3029:Cloxacillin 2999:Azidocillin 2989:Propicillin 2934:Penicillins 2809:from market 2732:Bedaquiline 2698:Clofazimine 2664:Thiocarlide 2654:Ethionamide 2602:inhibitor: 2577:Cycloserine 2541:Capreomycin 2510:Oxazolidone 2398:Solasulfone 2366:Antifolates 2351:Rifapentine 875:-dependent 840:synthesis: 779:convulsions 647:Cycloserine 551: g·mol 494:100.000.626 404:CHEBI:40009 240:Identifiers 198:~70% to 90% 69:Other names 60:Trade names 30:Cycloserine 8157:Categories 8039:JFD01307SC 7772:Ponceau SS 7747:Furosemide 7742:Evans blue 7708:Bumetamide 7668:-glutamate 7477:modulators 7470:metabolism 7393:AGN-241751 7365:Piretanide 7315:Furosemide 7300:Flupirtine 7277:Conantokin 7272:Caroverine 7267:Bumetanide 7200:Isoflurane 7170:Desflurane 7160:Chloroform 7099:Safaprodil 7094:Ro 25-6981 7035:Tiletamine 7020:Sabeluzole 7000:Remacemide 6945:Neramexane 6915:Methorphan 6900:Loperamide 6875:Lanicemine 6860:Indantadol 6825:Esketamine 6820:Ephenidine 6780:Dexoxadrol 6745:Arketamine 6730:Amantadine 6690:3-MeO-PCMo 6668:Putrescine 6611:MDL-105519 6586:Kynurenine 6566:Gavestinel 6481:SDZ-220581 6441:MDL-100453 6324:prasterone 6294:Spermidine 6267:Milacemide 6172:ACC (ACPC) 6058:Evans blue 6022:Topiramate 6012:Tezampanel 5942:Isoflurane 5819:Talampanel 5804:Perampanel 5799:Isoflurane 5784:GYKI-53655 5779:GYKI-52466 5774:Evans blue 5738:Zonampanel 5728:Topiramate 5718:Tezampanel 5693:Kynurenine 5653:Caroverine 5648:Becampanel 5598:Oxiracetam 5498:Aniracetam 5419:modulators 5288:Vigabatrin 5283:Valpromide 5252:lemon balm 5238:Phenelzine 5220:Gabaculine 5102:Vigabatrin 5067:Evans blue 5011:SKF-89976A 4971:Gabaculine 4946:Arecaidine 4903:modulators 4896:metabolism 4803:Candidates 4677:Nucleobase 4466:Tryptamine 4461:Synephrine 4372:Monoamines 4337:GHB system 4170:Amino acid 4071:Tyrocidine 4066:Gramicidin 4034:Bacitracin 4010:Fosfomycin 3981:Ramoplanin 3959:Daptomycin 3825:Relebactam 3798:Tazobactam 3729:Cefquinome 3716:Veterinary 3660:Cefquinome 3650:Cefozopran 3612:Ceftiolene 3602:Cefsulodin 3592:Cefodizime 3577:Cefditoren 3572:Ceftibuten 3520:Cefotaxime 3491:Loracarbef 3457:Cephamycin 3447:Ceforanide 3427:Cefuroxime 3384:Cefalonium 3354:Cefazaflur 3349:Cefazedone 3339:Cefadroxil 3206:Mecillinam 3185:Azlocillin 3161:Temocillin 3102:Hetacillin 3093:Ampicillin 2750:Pretomanid 2726:Terizidone 2714:Morinamide 2630:Hydrazides 2604:Ethambutol 2575:analogue: 2446:quinolones 2383:Acedapsone 2341:Rifampicin 2327:Rifamycins 2255:2023-10-22 2054:: 150–90. 1184:8 December 1103:References 1093:lurasidone 844:(Alr) and 836:stages of 805:Psychiatry 799:pyridoxine 771:dysarthria 759:depression 714:amino acid 706:alcoholics 702:depression 686:sleepiness 659:antibiotic 556:3D model ( 544:Molar mass 364:95IK5KI84Z 335:ChemSpider 270:CAS Number 249:IUPAC name 204:Metabolism 21:Cyclosarin 8106:See also: 7971:Bithionol 7926:β-Chloro- 7762:Nigericin 7474:transport 7467:Glutamate 7407:See also: 7387:Unsorted: 7330:MDL-27266 7310:FR-115427 7305:FPL-12495 7262:ARR-15896 7190:Halothane 7180:Enflurane 7138:Magnesium 7089:Ro 8-4304 7064:Eliprodil 6975:PD-137889 6935:Morphanol 6910:Methadone 6905:Memantine 6855:Ibogamine 6830:Etoxadrol 6760:ARL-16247 6750:ARL-12495 6735:Aptiganel 6700:4-MeO-PCP 6695:3-MeO-PCP 6685:3-MeO-PCE 6648:Co 101676 6621:MRZ 2/576 6571:GV-196771 6561:Felbamate 6538:CGP-39653 6518:ACEA-1328 6513:ACEA-1011 6456:NPC-17742 6451:NPC-12626 6436:LY-274614 6431:LY-235959 6426:LY-233053 6411:CGS-19755 6406:CGP-40116 6401:CGP-39653 6396:CGP-39551 6391:CGP-37849 6381:AP5 (APV) 6282:Sarcosine 6158:β-Fluoro- 6107:Glutamate 6102:Aspartate 6091:Agonists: 6048:Enflurane 5992:LY-382884 5952:ACEA-1011 5937:Halothane 5932:Enflurane 5927:Diazoxide 5900:LY-339434 5885:Glutamate 5849:Agonists: 5794:Irampanel 5789:Halothane 5764:Enflurane 5638:ACEA-1011 5613:Piracetam 5593:ORG-26576 5588:Nooglutyl 5578:LY-503430 5573:LY-451646 5568:LY-404187 5563:LY-395153 5558:LY-392098 5543:Diazoxide 5471:Glutamate 5440:Agonists: 5225:Isoniazid 5087:Nigericin 5052:β-Alanine 5026:Tiagabine 5016:SNAP-5114 4941:β-Alanine 4900:transport 4694:Adenosine 4498:Histamine 4482:-Tyramine 4474:-Tyramine 4317:Sarcosine 4297:β-Alanine 4292:α-Alanine 4114:Phase III 4102:Withdrawn 4078:Isoniazid 3964:Surfactin 3815:Avibactam 3793:Sulbactam 3766:Carumonam 3761:Tigemonam 3756:Aztreonam 3734:Cefovecin 3724:Ceftiofur 3655:Cefpirome 3626:Latamoxef 3617:Oxacephem 3587:Cefetamet 3542:Cefcapene 3466:Cefotetan 3461:Cefoxitin 3452:Cefuzonam 3442:Cefonicid 3422:Cefprozil 3394:Cefalotin 3369:Ceftezole 3359:Cefradine 3344:Cefapirin 3334:Cefalexin 3329:Cefazolin 3289:Ritipenem 3284:Faropenem 3277:Panipenem 3266:Meropenem 3256:Doripenem 3247:Ertapenem 3128:Epicillin 3049:Nafcillin 3044:Oxacillin 2892:β-lactams 2871:cell wall 2819:Phase III 2807:Withdrawn 2744:Delamanid 2721:Isoxazole 2693:Phenazine 2638:Isoniazid 2523:Sutezolid 2518:Linezolid 2495:Kanamycin 2403:Sulfoxone 2356:Rifalazil 2346:Rifabutin 2334:inhibitor 2231:201057546 2003:(1): 11. 1799:Harned RL 1034:Eli Lilly 1023:Economics 1009:Eli Lilly 932:Synthesis 883:-alanine 879:-alanine- 849:-alanine: 834:cytosolic 775:psychosis 724:cell wall 710:pregnancy 704:, or are 651:Seromycin 599:O=C1NOC1N 424:ChEMBL771 229:Excretion 218:half-life 120:Seromycin 93:Monograph 87:Drugs.com 64:Seromycin 8147:Medicine 7930:-alanine 7636:UCPH-101 7623:Theanine 7618:TFB-TBOA 7608:SYM-2081 7593:-2,4-PDC 7335:Metaphit 7245:Urethane 7133:Hydrogen 7130:Cations: 7040:Tramadol 6865:Ketamine 6850:Ibogaine 6765:Budipine 6680:3-HO-PCP 6606:LU-73068 6596:L-701324 6591:L-689560 6498:5,7-DCKA 6486:Selfotel 6368:SAGE-718 6363:SAGE-301 6358:SAGE-201 6299:Spermine 6289:Neomycin 6254:-Alanine 6246:L-687414 6205:-Alanine 6162:-alanine 6151:Theanine 6017:Theanine 5915:SYM-2081 5723:Theanine 5343:See also 5006:Riluzole 4986:Muscimol 4976:Guvacine 4733:-derived 4679:-derived 4660:instead. 4615:Oleamide 4546:-derived 4527:instead. 4384:Dopamine 4195:Agmatine 4172:-derived 4054:lysozyme 4000:Inhibit 3645:Cefepime 3621:Flomoxef 3607:Cefteram 3582:Cefotiam 3537:Cefdinir 3510:Cefixime 3471:Cefminox 3417:Cefaclor 3282:Penems ( 3272:Biapenem 3261:Imipenem 3070:spectrum 3068:Extended 2950:spectrum 2920:-alanine 2916:-alanyl- 2875:envelope 2705:Pyrazine 2490:Amikacin 2388:Diucifon 2223:31421635 2168:26132675 2127:22368237 2078:25550231 2029:23768232 1978:26238379 1929:Archived 1899:Archived 1865:Archived 1738:23529730 1613:22466372 1569:22305408 1561:23286234 1460:22579305 1411:26364274 1359:25957940 1310:Archived 1289:15199378 1233:(2019). 1217:Archived 1178:Archived 1043:Research 955:L-serine 830:-alanine 793:, while 787:seizures 720:-alanine 698:epilepsy 690:numbness 682:seizures 637:(verify) 315:DrugBank 131:ATC code 115:DailyMed 7379:saffron 7225:Toluene 7215:Octanol 7195:Hexanol 7150:Benzene 7126:TCN-213 7121:TCN-201 7116:MPX-007 7111:MPX-004 6705:8A-PDHQ 6643:Arcaine 6636:ZD-9379 6333:sulfate 6262:-Serine 6236:Glycine 6221:-Serine 6136:Proline 6063:NS-3763 6036:(e.g., 6027:UBP-302 5905:Proline 5747:(e.g., 5623:S-18986 5553:IDRA-21 5538:CX-1942 5533:CX-1739 5481:Proline 5077:Glycine 4966:EF-1502 4731:Vitamin 4625:RVD-Hpα 4580:AA-5-HT 4327:Taurine 4312:Proline 4302:Glycine 4245:Proline 4215:Glycine 3300:Cephems 2573:Alanine 2378:Dapsone 2214:6898334 2118:3446239 2069:4380664 2020:3686620 1969:4527085 1729:3716191 1689:3459696 1680:9293202 1509:4555420 1451:4001849 1402:4851259 1350:8939046 1139:3012401 995:History 923:-serine 809:A 2015 795:alcohol 783:paresis 763:vertigo 657:and an 653:, is a 549:102.093 511:Formula 324:DB00260 290:PubChem 279:68-41-7 147:) 141: ( 139:J04AB01 117::  8188:Aldols 8133:Portal 7991:GW5074 7851:CB-839 7824:Enzyme 7652:vGluTs 7255:Xylene 7155:Butane 6528:AV-101 6241:HA-966 5528:CX-717 5518:CX-614 5513:CX-546 5508:CX-516 5180:GABA-T 5116:Enzyme 5001:NO-711 4951:CI-966 4696:system 4570:2-ALPI 4491:Others 4322:Serine 4250:Serine 4097:WHO-EM 3804:Clavam 3238:Penems 2948:Narrow 2938:Penams 2802:WHO-EM 2393:Promin 2229:  2221:  2211:  2193:(12). 2166:  2125:  2115:  2076:  2066:  2027:  2017:  1976:  1966:  1736:  1726:  1687:  1677:  1611:  1567:  1559:  1507:  1500:247518 1497:  1458:  1448:  1409:  1399:  1357:  1347:  1287:  1209:  1147:462885 1145:  1137:  986:et al. 944:et al. 857:enzyme 789:, and 592:SMILES 444:007654 415:ChEMBL 384:D00877 234:Kidney 176:℞-only 174: 113:  7846:BPTES 7795:-ACDP 7793:trans 7683:7-CKA 7629:threo 7591:trans 7555:threo 7553:-(-)- 7540:HIP-B 7535:HIP-A 7520:-ACBD 7495:EAATs 7250:Xenon 6710:18-MC 6675:2-MDP 6503:7-CKA 6466:PEAQX 6192:B6B21 6182:AK-51 6116:-HCA) 6079:NMDAR 6002:NS102 5733:YM90K 5428:AMPAR 5311:Other 5037:VIAAT 4605:NAGly 4544:Lipid 4379:6-OHM 4271:GABOB 4044:Other 4016:DADAL 3973:Other 3789:Penam 3199:Other 2623:layer 2611:SQ109 2589:layer 2566:layer 2227:S2CID 1565:S2CID 1263:(PDF) 1143:S2CID 1001:Merck 612:InChI 558:JSmol 395:ChEBI 209:Liver 8077:AAOA 7981:EGCG 7966:AAOA 7884:AAOA 7787:SITS 7723:DIDS 7613:TBOA 7598:MPDC 7565:-αAA 7525:DHKA 7472:and 7345:MPEP 7285:-αAA 7143:Zinc 6970:PCPr 6940:NEFA 6626:PNQX 6556:DNQX 6543:CNQX 6476:PPDA 6461:PBPD 6331:DHEA 6316:DHEA 6226:DHPG 6177:ACPD 6167:ACBD 6131:NMDA 6097:AMAA 5997:NBQX 5972:GAMS 5967:DNQX 5957:CNQX 5875:ATPA 5870:AMPA 5708:PNQX 5703:NBQX 5678:GAMS 5668:DNQX 5658:CNQX 5643:ATPO 5603:PEPA 5461:BOAA 5456:AMPA 5362:GABA 5210:AOAA 5200:DABA 5146:AAOA 5072:GABA 5021:TACA 4956:DABA 4898:and 4889:GABA 4658:here 4656:See 4600:NADA 4575:2-OG 4560:2-AG 4525:here 4523:See 4266:GABA 4240:NAAG 4225:GSSG 4220:GSNO 2908:PBPs 2883:J01D 2879:J01C 2873:and 2303:and 2219:PMID 2164:PMID 2123:PMID 2074:PMID 2025:PMID 1974:PMID 1907:2015 1873:2015 1734:PMID 1685:PMID 1609:PMID 1557:PMID 1505:PMID 1456:PMID 1407:PMID 1355:PMID 1333:2015 1285:PMID 1207:ISBN 1186:2016 1135:PMID 1057:PTSD 918:and 791:coma 375:KEGG 355:UNII 344:5998 304:6234 188:data 83:AHFS 8060:GAD 7986:GTP 7954:GDH 7914:ALT 7889:AMB 7867:AST 7856:DON 7834:GAH 7518:cis 6508:ACC 6416:CPP 6386:AP7 6197:CCG 5837:KAR 5243:PEH 5215:EOS 5126:GAD 4921:GAT 4713:ATP 4708:AMP 4703:ADP 4630:SEA 4620:PEA 4610:OEA 4595:LPI 4590:DEA 4345:GHB 4276:GHB 4235:NAA 4006:NAM 2412:ASA 2370:DSI 2309:J04 2209:PMC 2199:doi 2154:doi 2113:PMC 2105:doi 2064:PMC 2056:doi 2052:149 2015:PMC 2005:doi 1964:PMC 1956:doi 1895:NYT 1838:doi 1811:doi 1780:doi 1724:PMC 1716:doi 1675:PMC 1667:doi 1636:doi 1632:120 1599:doi 1547:doi 1543:280 1495:PMC 1487:doi 1483:110 1446:PMC 1438:doi 1397:PMC 1389:doi 1345:PMC 1337:doi 1275:doi 1239:hdl 1127:doi 873:ATP 460:EPA 294:CID 144:WHO 8159:: 8119:• 8115:• 8111:• 8022:GS 7896:DL 7894:β- 7257:; 7145:; 7128:; 7106:; 7042:; 6670:; 6638:; 6488:; 6306:24 6301:; 6284:; 6153:; 6040:, 6029:; 5917:; 5821:; 5751:, 5740:; 5493:; 4833:O) 4785:S) 4110:: 4020:AR 4002:PG 3236:/ 3154:/ 2815:: 2747:, 2712:, 2652:: 2225:. 2217:. 2207:. 2191:44 2189:. 2185:. 2162:. 2150:76 2148:. 2144:. 2121:. 2111:. 2101:38 2099:. 2095:. 2072:. 2062:. 2050:. 2046:. 2023:. 2013:. 1999:. 1995:. 1972:. 1962:. 1952:78 1950:. 1946:. 1927:. 1923:. 1897:. 1893:. 1881:^ 1863:. 1859:. 1834:77 1832:. 1807:77 1805:. 1776:77 1774:. 1755:. 1732:. 1722:. 1712:57 1710:. 1706:. 1683:. 1673:. 1661:. 1657:. 1630:. 1607:. 1593:. 1589:. 1577:^ 1563:. 1555:. 1541:. 1537:. 1517:^ 1503:. 1493:. 1481:. 1477:. 1454:. 1444:. 1434:71 1432:. 1428:. 1405:. 1395:. 1385:19 1383:. 1379:. 1367:^ 1353:. 1343:. 1331:. 1327:. 1297:^ 1283:. 1271:29 1269:. 1265:. 1215:. 1155:^ 1141:. 1133:. 1123:25 1121:. 1099:. 1083:, 1019:. 939:DL 785:, 777:, 769:, 739:. 726:. 700:, 696:, 684:, 680:, 170:US 110:US 8135:: 8083:L 7936:L 7928:L 7735:L 7666:L 7589:- 7587:L 7579:L 7571:L 7563:L 7551:L 7459:e 7452:t 7445:v 7381:) 7377:( 7283:D 6549:D 6339:) 6335:( 6326:) 6322:( 6308:S 6260:L 6252:L 6219:D 6211:D 6203:D 6160:D 6114:L 6044:) 5755:) 5408:e 5401:t 5394:v 5364:A 5254:) 5250:( 5231:L 5152:L 4880:e 4873:t 4866:v 4842:) 4840:2 4831:2 4819:) 4817:3 4783:2 4480:p 4472:m 4444:p 4436:m 4154:e 4147:t 4140:v 4036:) 4026:) 4018:/ 4012:) 3863:) 3859:( 3832:) 3810:) 3806:( 3800:) 3791:( 3628:) 3619:( 3533:) 3493:) 3489:( 3483:) 3459:( 3291:) 3279:) 3268:) 3254:( 3212:) 3208:( 3124:) 3095:( 3040:) 3031:( 2940:) 2936:( 2924:) 2918:D 2914:D 2885:) 2881:- 2877:( 2859:e 2852:t 2845:v 2753:) 2741:( 2728:) 2724:( 2716:) 2708:( 2700:) 2696:( 2632:/ 2598:/ 2443:/ 2432:) 2423:( 2368:/ 2329:/ 2311:) 2307:( 2289:e 2282:t 2275:v 2258:. 2233:. 2201:: 2170:. 2156:: 2129:. 2107:: 2080:. 2058:: 2031:. 2007:: 2001:3 1980:. 1958:: 1909:. 1875:. 1844:. 1840:: 1817:. 1813:: 1786:. 1782:: 1759:. 1740:. 1718:: 1691:. 1669:: 1663:3 1642:. 1638:: 1615:. 1601:: 1595:5 1571:. 1549:: 1511:. 1489:: 1462:. 1440:: 1413:. 1391:: 1361:. 1339:: 1291:. 1277:: 1241:: 1188:. 1149:. 1129:: 1089:D 1077:D 1073:D 1065:D 1061:D 1049:D 981:D 975:L 969:L 963:L 950:D 921:D 897:D 893:D 889:D 881:D 877:D 869:D 865:D 861:L 851:D 847:D 828:D 718:D 560:) 537:2 534:O 531:2 528:N 525:6 522:H 519:3 516:C 462:) 458:( 258:R 256:( 172:: 85:/ 74:D 23:.

Index

Cyclosarin


Trade names
AHFS
Drugs.com
Monograph
License data
DailyMed
Seromycin
ATC code
J04AB01
WHO
Legal status
℞-only
Pharmacokinetic
Bioavailability
Metabolism
Liver
Elimination half-life
Excretion
Kidney
IUPAC name
CAS Number
68-41-7
PubChem
6234
DrugBank
DB00260
ChemSpider

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.