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Cyclooxygenase

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239: 5309: 427: 841:, and other members of this drug class. Because COX-2 is usually specific to inflamed tissue, there is much less gastric irritation associated with COX-2 inhibitors, with a decreased risk of peptic ulceration. The selectivity of COX-2 does not seem to negate other side-effects of NSAIDs, most notably an increased risk of 1183:
Arachidonic acid is a component of membrane phospholipids released either in a one-step process, after phospholipase A2 (PLA2) action, or a two-step process, after phospholipase C and DAG lipase actions. Arachidonic acid is then metabolized by cyclooxygenase (COX) and 5-lipoxygenase, resulting in the
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Caution should be exercised in combining low dose aspirin with COX-2 inhibitors due to potential increased damage to the gastric mucosa. COX-2 is upregulated when COX-1 is suppressed with aspirin, which is thought to be important in enhancing mucosal defense mechanisms and lessening the erosion by
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synthesis has the effect of reduced inflammation, as well as antipyretic, antithrombotic and analgesic effects. The most frequent adverse effect of NSAIDs is irritation of the gastric mucosa as prostaglandins normally have a protective role in the gastrointestinal tract. Some NSAIDs are also acidic
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This evidence, however, has been contradicted by the 2016 PRECISION (Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen) trial of 24,081 participants, which shows a lower incidence of cardiovascular death (including hemorrhagic death), nonfatal myocardial
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Nissen SE, Yeomans ND, Solomon DH, Luscher TF, Libby P, Husni ME, Graham DY, Borer JS, Wisniewski LM, Wolski KE, Qiuqing W, Menon V, Ruschitzka F, Gaffney M, Beckerman B, Berger MF, Weihang B, Lincoff AM (December 2016). "Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis".
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even with short-term use. A 2006 analysis of 138 randomised trials and almost 150,000 participants showed that selective COX-2 inhibitors are associated with a moderately increased risk of vascular events, mainly due to a twofold increased risk of
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Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, Pak JY, Gildehaus D, Miyashiro JM, Penning TD, Seibert K, Isakson PC, Stallings WC (1996). "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents".
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synthesis of prostaglandins and leukotrienes, respectively. These intracellular messengers play an important role in the regulation of signal transduction implicated in pain and inflammatory responses.
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O'Leary KA, de Pascual-Teresa S, de Pascual-Tereasa S, Needs PW, Bao YP, O'Brien NM, Williamson G (July 2004). "Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription".
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sterically hinders). Drug molecules, such as DuP-697 and the coxibs derived from it, bind to this alternative site and are considered to be selective inhibitors of COX-2.
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COX is a common target for anti-inflammatory drugs. The most significant difference between the isoenzymes, which allows for selective inhibition, is the substitution of
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Nina M, Bernèche S, Roux B (2000). "Anchoring of a monotopic membrane protein: the binding of prostaglandin H2 synthase-1 to the surface of a phospholipid bilayer".
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Inhibition of COX-2 using celecoxib has been shown to reduce the immunosuppressive TGFβ expression in hepatocytes attenuating EMT in human hepatocellular carcinoma
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Albert D, ZĂĽndorf I, Dingermann T, MĂĽller WE, Steinhilber D, Werz O (December 2002). "Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase".
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Zhang Y, Mills GL, Nair MG (December 2002). "Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa".
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Zhang Y, Mills GL, Nair MG (2003). "Cyclooxygenase inhibitory and antioxidant compounds from the fruiting body of an edible mushroom, Agrocybe aegerita".
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Litalien C, Beaulieu P (2011). "Chapter 117 – Molecular Mechanisms of Drug Actions: From Receptors to Effectors". In Fuhrman BP, Zimmerman JJ (eds.).
759:, a small 4-helical membrane anchor, and a core heme-peroxidase catalytic domain. Both form dimers. The membrane anchor fixes the proteins into the 2876: 2496: 460: 275: 3723: 3703: 3259: 3209: 755:, respectively, and having 65% amino acid sequence homology and near-identical catalytic sites. Both proteins have three domains: an N-terminal 4029: 3494: 3384: 3379: 3364: 3299: 3249: 3204: 2769: 4436: 4267: 4257: 3681: 3359: 3339: 3324: 3314: 3294: 3289: 3244: 3219: 3184: 3030: 2861: 2639: 2537: 2476: 2437: 2236: 2226: 2134: 2022: 210: 4466: 4461: 4426: 4401: 4262: 4123: 3980: 3581: 3576: 3374: 3354: 3349: 3344: 3329: 3319: 3309: 3284: 3274: 3269: 3264: 3254: 3239: 3234: 3194: 3153: 3133: 3090: 3085: 3070: 3060: 3055: 3040: 2919: 2841: 2796: 2710: 2686: 2676: 2124: 4451: 4406: 4217: 4163: 4148: 3997: 3708: 3656: 3541: 3389: 3334: 3304: 3279: 3229: 3224: 3214: 3199: 3148: 3143: 3100: 3035: 3025: 2995: 2939: 2909: 2866: 2856: 2705: 2629: 2481: 2394: 2191: 1817: 4456: 4431: 4421: 4272: 4247: 4232: 4197: 4173: 4168: 3919: 3369: 3189: 3123: 3095: 3080: 3075: 3050: 2666: 2634: 2614: 2557: 2442: 2365: 2360: 2355: 2350: 2186: 2181: 4559: 4476: 4192: 4138: 4133: 3168: 3015: 2924: 2881: 2432: 2345: 2231: 2211: 2206: 2201: 1723:"Cyclooxygenase-2 and Akt mediate multiple growth-factor-induced epithelial-mesenchymal transition in human hepatocellular carcinoma" 970:
and other conditions as a consequence of the fact that they provide less cardiovascular risk than other treatments including NSAIDs.
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Picot D, Loll PJ, Garavito RM (January 1994). "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1".
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Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, Cravatt BF, Basbaum AI, Zygmunt PM (September 2005).
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Kumar, V., Abbas, A. K., & Aster, J. C. (2017). Robbins Basic Pathology (10th ed.). Elsevier - Health Sciences Division.
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In terms of their molecular biology, COX-1 and COX-2 are of similar molecular weight, approximately 70 and 72 k
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provide alternative fatty acids to arachidonic acid. These acids can be turned into some anti-inflammatory
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The classical COX inhibitors are not selective and inhibit all types of COX. The resulting inhibition of
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infarction, or nonfatal stroke for Celecoxib as compared to both Naproxen and Ibuprofen.
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Cyclooxygenase-2 (prostaglandin synthase-2) in complex with a COX-2 selective inhibitor
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Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C (June 2006).
5323: 5107: 5066: 4499: 4183: 3968: 3865: 3743: 3728: 3661: 3591: 963: 899: 817: 752: 658:. The specific reaction catalyzed is the conversion from arachidonic acid to 639: 161: 1412: 5056: 4804: 4800: 4039: 3956: 3882: 3860: 3813: 3748: 3718: 3698: 3693: 3616: 3504: 2929: 2891: 2759: 2586: 2422: 2307: 2114: 1772: 1756: 1707: 1671: 1614: 1575: 1544: 1509: 1455: 1420: 1385: 1310: 1267: 1258: 1223: 1214: 1197: 673: 643: 244: 1699: 1126: 1061: 5280: 5215: 5051: 4514: 4416: 4357: 4227: 4212: 4153: 4118: 4096: 4076: 4024: 4009: 3951: 3909: 3835: 3803: 3788: 3621: 3606: 3531: 3469: 3464: 3138: 2811: 2774: 2749: 2744: 2591: 2547: 2506: 2501: 2399: 2335: 2312: 2302: 2221: 2196: 2163: 2129: 1944: 1338: 1332: 858: 821: 788: 705: 635: 627: 525: 340: 99: 1798:
A discussion of the enzymatic mechanism, including interactive 3D models
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Crystallographic structure of prostaglandin H2 synthase-1 complex with
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Liu J, Seibold SA, Rieke CJ, Song I, Cukier RI, Smith WL (June 2007).
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has been shown to inhibit COX-1 around 3-18 times as much as aspirin.
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unbalanced by prostacyclin (which is reduced by COX-2 inhibition).
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which may cause additional damage to the gastrointestinal tract.
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Moreno J, Krishnan AV, Peehl DM, Feldman D (July–August 2006).
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inhibition of COX can provide relief from the symptoms of
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COX-2 inhibitors have been found to increase the risk of
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Discovery and development of COX-2 selective inhibitors
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because the root symbol "COX" was already used for the
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is a COX inhibitor, a fact to which some or all of its
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In 1146: 1144: 723:, "PTGS" is officially used for this family of 4389: 1398: 1363: 5022: 4587: 4366: 2822: 2023: 1818: 1474:"Fish oil: what the prescriber needs to know" 1081: 1079: 930:Cardiovascular side-effects of COX inhibitors 833:Selectivity for COX-2 is the main feature of 2950: 1714: 1678: 1629: 1551: 1467: 1465: 1427: 1392: 1141: 1357: 1230: 873:, and etoricoxib, are still on the market. 5029: 5015: 4594: 4580: 2030: 2016: 1825: 1811: 1727:Journal of Gastroenterology and Hepatology 1472:Cleland LG, James MJ, Proudman SM (2006). 1366:Journal of Agricultural and Food Chemistry 1325: 1076: 1015: 630:) that is responsible for biosynthesis of 425: 237: 21:"COX" redirects here. For other uses, see 1780:at the U.S. National Library of Medicine 1746: 1661: 1499: 1489: 1462: 1257: 1213: 876: 1793:Cyclooxygenase: Proteopedia, life in 3D 1588: 5322: 3421: 5010: 4575: 2011: 1806: 811:non-steroidal anti-inflammatory drugs 4787:24-hydroxycholesterol 7α-hydroxylase 4044:Selective COX-2 inhibitors (coxibs): 791:side-pocket in the enzyme (which Ile 787:residue in COX-2 allows access to a 682:Nonsteroidal anti-inflammatory drugs 2153:Tooltip Prostaglandin D2 receptor 2 2096:Tooltip Prostaglandin D2 receptor 1 1246:The Journal of Biological Chemistry 1202:The Journal of Biological Chemistry 974:Effects of COX on the immune system 902:by COX instead of pro-inflammatory 798: 609:prostaglandin-endoperoxide synthase 31:Prostaglandin-endoperoxide synthase 13: 4015:AM-404 (N-arachidonoylaminophenol) 3833:Anthranilic acids (fenamic acids): 3485:Mesalazine (5-aminosalicylic acid) 2576:Tooltip Prostaglandin EP4 receptor 2461:Tooltip Prostaglandin EP3 receptor 2384:Tooltip Prostaglandin EP2 receptor 2277:Tooltip Prostaglandin EP1 receptor 1169:10.1016/B978-0-323-07307-3.10117-X 892:have been found to inhibit COX-2. 14: 5361: 4505:Îł-Linolenic acid (gamolenic acid) 3851:Meclofenamic acid (meclofenamate) 2260:Tooltip Prostaglandin E2 receptor 2079:Tooltip Prostaglandin D2 receptor 1953:5-Lipoxygenase activating protein 1766: 5307: 4560:Leukotriene signaling modulators 4352:Tooltip Prostaglandin F synthase 4333:Tooltip Prostaglandin E synthase 4292:Tooltip Prostaglandin D synthase 2734:Tooltip Prostaglandin F receptor 1739:10.1111/j.1440-1746.2011.06980.x 1478:Arthritis Research & Therapy 809:The main COX inhibitors are the 4767:Cholesterol 7 alpha-hydroxylase 4713:Flavin-containing monooxygenase 3871:Talinflumic acid (talinflumate) 3861:Morniflumic acid (morniflumate) 3841:Floctafenic acid (floctafenate) 3824:Tiaprofenic acid (tiaprofenate) 1582: 1516: 828: 770: 4394:Tooltip Thromboxane A synthase 3445:Aspirin (acetylsalicylic acid) 2659:16,16-Dimethyl Prostaglandin E 1348: 1282: 1189: 805:Mechanism of action of aspirin 779:at position 523 in COX-1 with 1: 4553:Receptor/signaling modulators 4375:Tooltip Prostacyclin synthase 3876:Tolfenamic acid (tolfenamate) 3846:Flufenamic acid (flufenamate) 3836:Etofenamic acid (etofenamate) 2892:Prostacyclin (prostaglandin I 2831:Tooltip Prostacyclin receptor 1976:Gamma-glutamyl transpeptidase 1964:LTA4 hydrolase (B4 synthesis) 1537:10.1016/s0006-2952(02)01387-4 1009: 2959:Tooltip Thromboxane receptor 1921:Prostaglandin-E2 9-reductase 1448:10.1016/j.mrfmmm.2004.01.015 654:family, it is also known as 7: 5335:Genes on human chromosome 1 5330:Genes on human chromosome 9 5036: 4996:Deoxyhypusine monooxygenase 4025:Paracetamol (acetaminophen) 3856:Mefenamic acid (mefenamate) 3510:Salicylate (salicylic acid) 1957:Arachidonate 5-lipoxygenase 1788:GONUTS Page: Cyclooxygenase 1589:Wallace JL (October 2008). 1291:European Biophysics Journal 981: 652:animal-type heme peroxidase 619:(specifically, a family of 10: 5366: 5350:Integral membrane proteins 3704:Bucloxic acid (blucloxate) 3622:Indometacin (indomethacin) 1773:The Cyclooxygenase Protein 1607:10.1152/physrev.00004.2008 1000:(not functional in humans) 802: 746: 656:prostaglandin G/H synthase 20: 5193: 5185:Michaelis–Menten kinetics 5157: 5126: 5095: 5044: 4991:Ecdysone 20-monooxygenase 4950: 4942:Stearoyl-CoA desaturase-1 4922: 4914:Dopamine beta-hydroxylase 4900: 4882:Phenylalanine hydroxylase 4863: 4831: 4795: 4695: 4622: 4544: 4489: 4387: 4364: 4345: 4326: 4281: 3866:Niflumic acid (niflumate) 3419: 3402: 3177: 2970:Carbocyclic thromboxane A 2948: 2820: 2723: 2648: 2566: 2451: 2374: 2267: 2249: 2143: 2086: 2068: 2051: 1989: 1943: 1880: 1852: 1654:10.1136/bmj.332.7553.1302 881:Culinary mushrooms, like 783:in COX-2. The smaller Val 700:. The active metabolite ( 584: 574: 569: 565: 548: 536: 531: 519: 507: 495: 483: 471: 459: 451: 441: 436: 424: 417: 399: 389: 384: 380: 363: 351: 346: 334: 322: 310: 298: 286: 274: 266: 256: 251: 236: 229: 209: 197: 185: 180: 176: 160: 141: 129: 117: 105: 93: 81: 69: 64: 52: 40: 35: 30: 5077:Diffusion-limited enzyme 4184:Menatetrenone (vitamin K 4007:Aminophenols (anilines): 1782:Medical Subject Headings 1525:Biochemical Pharmacology 4510:Dihomo-Îł-linolenic acid 3907:Enolic acids (oxicams): 3450:Benorilate (benorylate) 1413:10.1078/0944-7113-00272 1155:Pediatric Critical Care 857:through an increase of 607:), officially known as 4976:Squalene monooxygenase 4892:Tryptophan hydroxylase 4641:HIF prolyl-hydroxylase 4309:selenium tetrachloride 1259:10.1074/jbc.M501489200 1215:10.1074/jbc.M701235200 877:Natural COX inhibition 5170:Eadie–Hofstee diagram 5103:Allosteric regulation 4772:Methane monooxygenase 4745:Nitric oxide synthase 3978:Aminonicotinic acids: 1872:Diacylglycerol lipase 1700:10.1056/NEJMoa1611593 1595:Physiological Reviews 941:myocardial infarction 761:endoplasmic reticulum 712:has been attributed. 5180:Lineweaver–Burk plot 4887:Tyrosine hydroxylase 4611:steroid hydroxylases 3627:Indometacin farnesil 3480:Magnesium salicylate 3111:Pinane thromboxane A 2872:Iloprost (ciloprost) 2492:Iloprost (ciloprost) 2298:Iloprost (ciloprost) 968:rheumatoid arthritis 733:cytochrome c oxidase 23:Cox (disambiguation) 4837:iron–sulfur protein 3455:Carbasalate calcium 1564:Anticancer Research 1111:1996Natur.384..644K 1046:1994Natur.367..243P 696:isozyme are called 662:via a short-living 5139:Enzyme superfamily 5072:Enzyme promiscuity 4636:Prolyl hydroxylase 4317:selenium disulfide 3949:4-Aminoquinolines: 1303:10.1007/PL00006649 710:therapeutic effect 684:(NSAIDs), such as 650:. A member of the 5295: 5294: 5004: 5003: 4670:Lysyl hydroxylase 4569: 4568: 4485: 4484: 3520:Sodium salicylate 3490:Methyl salicylate 3413: 3398: 3397: 2719: 2718: 2245: 2244: 2062: 2005: 2004: 1436:Mutation Research 1378:10.1021/jf0257648 1178:978-0-323-07307-3 962:Fish oils (e.g., 715:In medicine, the 598: 597: 594: 593: 413: 412: 409: 408: 225: 224: 221: 220: 124:metabolic pathway 5357: 5312: 5311: 5303: 5175:Hanes–Woolf plot 5118:Enzyme activator 5113:Enzyme inhibitor 5087:Enzyme catalysis 5031: 5024: 5017: 5008: 5007: 4596: 4589: 4582: 4573: 4572: 4520:Arachidonic acid 4395: 4391: 4376: 4372: 4353: 4349: 4334: 4330: 4293: 4289: 4116:Others/unsorted: 3691:Propionic acids: 3672:Sulindac sulfide 3437:Salicylic acids: 3428: 3423: 3417: 3416: 3407: 2960: 2956: 2832: 2828: 2735: 2731: 2577: 2573: 2462: 2458: 2385: 2381: 2278: 2274: 2265: 2264: 2261: 2257: 2154: 2150: 2097: 2093: 2084: 2083: 2080: 2076: 2066: 2065: 2056: 2032: 2025: 2018: 2009: 2008: 1860:Phospholipase A2 1838:lipid metabolism 1827: 1820: 1813: 1804: 1803: 1761: 1760: 1750: 1718: 1712: 1711: 1682: 1676: 1675: 1665: 1648:(7553): 1302–8. 1633: 1627: 1626: 1586: 1580: 1579: 1555: 1549: 1548: 1520: 1514: 1513: 1503: 1493: 1469: 1460: 1459: 1431: 1425: 1424: 1396: 1390: 1389: 1361: 1355: 1352: 1346: 1341: 1335: 1329: 1323: 1322: 1286: 1280: 1279: 1261: 1252:(36): 31405–12. 1243: 1234: 1228: 1227: 1217: 1208:(25): 18233–44. 1193: 1187: 1186: 1158: 1148: 1139: 1138: 1119:10.1038/384644a0 1093: 1083: 1074: 1073: 1054:10.1038/367243a0 1029: 1019: 998:Cyclooxygenase-3 993:Cyclooxygenase-2 988:Cyclooxygenase-1 936:atherothrombosis 799:Classical NSAIDs 698:COX-2 inhibitors 664:prostaglandin G2 660:prostaglandin H2 648:arachidonic acid 567: 566: 429: 419:Cyclooxygenase 2 415: 414: 382: 381: 241: 231:Cyclooxygenase 1 227: 226: 178: 177: 28: 27: 18:Class of enzymes 5365: 5364: 5360: 5359: 5358: 5356: 5355: 5354: 5320: 5319: 5318: 5306: 5298: 5296: 5291: 5203:Oxidoreductases 5189: 5165:Enzyme kinetics 5153: 5149:List of enzymes 5122: 5091: 5062:Catalytic triad 5040: 5035: 5005: 5000: 4954:- miscellaneous 4946: 4918: 4896: 4859: 4827: 4791: 4782:14α-demethylase 4691: 4618: 4603:Oxidoreductases 4600: 4570: 4565: 4540: 4536: 4533:Prostaglandin H 4528: 4525:Prostaglandin G 4481: 4393: 4383: 4381:Tranylcypromine 4374: 4370: 4360: 4351: 4341: 4332: 4322: 4313:sodium selenite 4291: 4287: 4277: 4223:Rosmarinic acid 4187: 3995:Sulfonanilides: 3898:Oxyphenbutazone 3424: 3406: 3394: 3173: 3114: 2986: 2973: 2958: 2954: 2944: 2904: 2901:Prostaglandin E 2896:, epoprostenol) 2895: 2830: 2826: 2816: 2791: 2788:Prostaglandin F 2783: 2780:Prostaglandin D 2733: 2729: 2715: 2700: 2697:Prostaglandin F 2662: 2644: 2609: 2606:Prostaglandin E 2600: 2597:Prostaglandin E 2575: 2572: 2562: 2543:Ricinoleic acid 2532: 2529:Prostaglandin E 2523: 2520:Prostaglandin E 2515: 2512:Prostaglandin D 2460: 2457: 2447: 2417: 2414:Prostaglandin E 2408: 2405:Prostaglandin E 2383: 2380: 2370: 2330: 2327:Prostaglandin E 2321: 2318:Prostaglandin E 2276: 2273: 2259: 2255: 2241: 2172: 2169:Prostaglandin D 2152: 2149: 2139: 2110: 2107:Prostaglandin D 2095: 2092: 2078: 2074: 2055: 2047: 2036: 2006: 2001: 1985: 1939: 1876: 1867:Phospholipase C 1848: 1831: 1769: 1764: 1719: 1715: 1683: 1679: 1634: 1630: 1587: 1583: 1570:(4A): 2525–30. 1556: 1552: 1531:(12): 1767–75. 1521: 1517: 1470: 1463: 1442:(1–2): 245–54. 1432: 1428: 1397: 1393: 1362: 1358: 1353: 1349: 1337: 1331: 1330: 1326: 1287: 1283: 1241: 1235: 1231: 1194: 1190: 1179: 1149: 1142: 1105:(6610): 644–8. 1085: 1084: 1077: 1040:(6460): 243–9. 1021: 1020: 1016: 1012: 984: 976: 932: 879: 831: 807: 801: 794: 786: 773: 757:EGF-like domain 749: 432: 247: 26: 19: 12: 11: 5: 5363: 5353: 5352: 5347: 5342: 5340:Prostaglandins 5337: 5332: 5317: 5316: 5293: 5292: 5290: 5289: 5276: 5263: 5250: 5237: 5224: 5211: 5197: 5195: 5191: 5190: 5188: 5187: 5182: 5177: 5172: 5167: 5161: 5159: 5155: 5154: 5152: 5151: 5146: 5141: 5136: 5130: 5128: 5127:Classification 5124: 5123: 5121: 5120: 5115: 5110: 5105: 5099: 5097: 5093: 5092: 5090: 5089: 5084: 5079: 5074: 5069: 5064: 5059: 5054: 5048: 5046: 5042: 5041: 5034: 5033: 5026: 5019: 5011: 5002: 5001: 4999: 4998: 4993: 4988: 4983: 4978: 4973: 4966:Heme oxygenase 4963: 4961:Cyclooxygenase 4957: 4955: 4948: 4947: 4945: 4944: 4939: 4933: 4931: 4920: 4919: 4917: 4916: 4910: 4908: 4898: 4897: 4895: 4894: 4889: 4884: 4878: 4876: 4861: 4860: 4858: 4857: 4852: 4847: 4841: 4839: 4829: 4828: 4826: 4825: 4820: 4815: 4809: 4807: 4793: 4792: 4790: 4789: 4784: 4779: 4774: 4769: 4764: 4763: 4762: 4757: 4752: 4742: 4741: 4740: 4735: 4730: 4725: 4720: 4709: 4707: 4693: 4692: 4690: 4689: 4688: 4687: 4682: 4672: 4667: 4666: 4665: 4660: 4659: 4658: 4653: 4648: 4632: 4630: 4628:2-oxoglutarate 4620: 4619: 4599: 4598: 4591: 4584: 4576: 4567: 4566: 4564: 4563: 4556: 4549: 4545: 4542: 4541: 4539: 4538: 4534: 4530: 4526: 4522: 4517: 4515:Diacylglycerol 4512: 4507: 4502: 4493: 4491: 4487: 4486: 4483: 4482: 4480: 4479: 4474: 4469: 4464: 4459: 4454: 4449: 4444: 4439: 4434: 4429: 4424: 4419: 4414: 4409: 4404: 4398: 4396: 4385: 4384: 4379: 4377: 4368: 4362: 4361: 4356: 4354: 4343: 4342: 4337: 4335: 4324: 4323: 4321: 4320: 4302: 4296: 4294: 4285: 4279: 4278: 4276: 4275: 4270: 4265: 4260: 4255: 4250: 4245: 4240: 4235: 4230: 4225: 4220: 4215: 4210: 4205: 4200: 4195: 4190: 4185: 4181: 4176: 4171: 4166: 4161: 4156: 4151: 4146: 4141: 4136: 4131: 4126: 4121: 4109: 4104: 4099: 4094: 4089: 4084: 4079: 4074: 4069: 4064: 4059: 4054: 4049: 4037: 4032: 4027: 4022: 4017: 4012: 4000: 3988: 3983: 3971: 3959: 3954: 3942: 3937: 3932: 3927: 3922: 3917: 3912: 3903:Phenylbutazone 3900: 3895: 3890: 3885: 3873: 3868: 3863: 3858: 3853: 3848: 3843: 3838: 3826: 3821: 3816: 3811: 3806: 3801: 3796: 3791: 3786: 3781: 3776: 3771: 3766: 3761: 3756: 3751: 3746: 3741: 3736: 3731: 3726: 3721: 3716: 3711: 3706: 3701: 3696: 3684: 3679: 3674: 3669: 3664: 3659: 3654: 3649: 3644: 3639: 3634: 3629: 3624: 3619: 3614: 3609: 3604: 3599: 3594: 3589: 3584: 3579: 3574: 3569: 3564: 3559: 3554: 3549: 3544: 3539: 3534: 3522: 3517: 3512: 3507: 3502: 3497: 3492: 3487: 3482: 3477: 3472: 3467: 3462: 3457: 3452: 3447: 3442: 3433: 3431: 3414: 3400: 3399: 3396: 3395: 3393: 3392: 3387: 3382: 3377: 3372: 3367: 3362: 3357: 3352: 3347: 3342: 3337: 3332: 3327: 3322: 3317: 3312: 3307: 3302: 3297: 3292: 3287: 3282: 3277: 3272: 3267: 3262: 3257: 3252: 3247: 3242: 3237: 3232: 3227: 3222: 3217: 3212: 3207: 3202: 3197: 3192: 3187: 3181: 3179: 3175: 3174: 3172: 3171: 3166: 3161: 3156: 3151: 3146: 3141: 3136: 3131: 3126: 3121: 3116: 3112: 3108: 3103: 3098: 3093: 3088: 3083: 3078: 3073: 3068: 3063: 3058: 3053: 3048: 3043: 3038: 3033: 3028: 3023: 3018: 3013: 3008: 2999: 2998: 2993: 2988: 2984: 2980: 2975: 2971: 2963: 2961: 2952: 2946: 2945: 2943: 2942: 2933: 2932: 2927: 2922: 2917: 2912: 2907: 2902: 2898: 2893: 2889: 2884: 2879: 2877:Isocarbacyclin 2874: 2869: 2864: 2859: 2854: 2849: 2844: 2835: 2833: 2824: 2818: 2817: 2815: 2814: 2809: 2804: 2799: 2794: 2789: 2785: 2781: 2777: 2772: 2767: 2762: 2757: 2752: 2747: 2738: 2736: 2727: 2721: 2720: 2717: 2716: 2714: 2713: 2708: 2703: 2698: 2694: 2689: 2684: 2679: 2674: 2669: 2664: 2660: 2652: 2650: 2646: 2645: 2643: 2642: 2637: 2632: 2627: 2618: 2617: 2612: 2610:(dinoprostone) 2607: 2603: 2598: 2594: 2589: 2580: 2578: 2570: 2564: 2563: 2561: 2560: 2551: 2550: 2545: 2540: 2535: 2533:(dinoprostone) 2530: 2526: 2521: 2517: 2513: 2509: 2504: 2499: 2497:Isocarbacyclin 2494: 2489: 2484: 2479: 2474: 2465: 2463: 2455: 2449: 2448: 2446: 2445: 2440: 2435: 2426: 2425: 2420: 2418:(dinoprostone) 2415: 2411: 2406: 2402: 2397: 2388: 2386: 2378: 2372: 2371: 2369: 2368: 2363: 2358: 2353: 2348: 2339: 2338: 2333: 2331:(dinoprostone) 2328: 2324: 2319: 2315: 2310: 2305: 2300: 2295: 2290: 2281: 2279: 2271: 2262: 2253: 2247: 2246: 2243: 2242: 2240: 2239: 2234: 2229: 2224: 2219: 2214: 2209: 2204: 2199: 2194: 2189: 2184: 2175: 2174: 2170: 2166: 2157: 2155: 2147: 2141: 2140: 2138: 2137: 2132: 2127: 2118: 2117: 2112: 2108: 2100: 2098: 2090: 2081: 2072: 2063: 2049: 2048: 2035: 2034: 2027: 2020: 2012: 2003: 2002: 2000: 1999: 1993: 1991: 1987: 1986: 1984: 1983: 1981:LTD4 hydrolase 1978: 1973: 1967: 1966: 1960: 1959: 1949: 1947: 1941: 1940: 1938: 1937: 1931: 1930: 1924: 1923: 1918: 1912: 1911: 1905: 1904: 1903: 1902: 1897: 1890:Cyclooxygenase 1886: 1884: 1878: 1877: 1875: 1874: 1869: 1863: 1862: 1856: 1854: 1850: 1849: 1830: 1829: 1822: 1815: 1807: 1801: 1800: 1795: 1790: 1785: 1778:Cyclooxygenase 1775: 1768: 1767:External links 1765: 1763: 1762: 1713: 1677: 1628: 1601:(4): 1547–65. 1581: 1550: 1515: 1491:10.1186/ar1876 1461: 1426: 1391: 1372:(26): 7581–5. 1356: 1347: 1324: 1281: 1229: 1188: 1177: 1140: 1075: 1013: 1011: 1008: 1007: 1006: 1001: 995: 990: 983: 980: 975: 972: 931: 928: 904:prostaglandins 878: 875: 843:kidney failure 830: 827: 800: 797: 792: 784: 772: 769: 748: 745: 670:Pharmaceutical 666:intermediate. 640:prostaglandins 601:Cyclooxygenase 596: 595: 592: 591: 586: 582: 581: 576: 572: 571: 563: 562: 552: 546: 545: 540: 534: 533: 529: 528: 523: 517: 516: 511: 505: 504: 499: 493: 492: 487: 481: 480: 475: 469: 468: 463: 457: 456: 453: 449: 448: 443: 439: 438: 434: 433: 430: 422: 421: 411: 410: 407: 406: 401: 397: 396: 391: 387: 386: 378: 377: 367: 361: 360: 355: 349: 348: 344: 343: 338: 332: 331: 326: 320: 319: 314: 308: 307: 302: 296: 295: 290: 284: 283: 278: 272: 271: 268: 264: 263: 258: 254: 253: 249: 248: 242: 234: 233: 223: 222: 219: 218: 213: 207: 206: 201: 195: 194: 189: 183: 182: 174: 173: 164: 158: 157: 146: 139: 138: 133: 127: 126: 121: 115: 114: 109: 103: 102: 97: 91: 90: 85: 79: 78: 73: 67: 66: 62: 61: 56: 50: 49: 44: 38: 37: 33: 32: 17: 9: 6: 4: 3: 2: 5362: 5351: 5348: 5346: 5343: 5341: 5338: 5336: 5333: 5331: 5328: 5327: 5325: 5315: 5310: 5305: 5304: 5301: 5287: 5283: 5282: 5277: 5274: 5270: 5269: 5264: 5261: 5257: 5256: 5251: 5248: 5244: 5243: 5238: 5235: 5231: 5230: 5225: 5222: 5218: 5217: 5212: 5209: 5205: 5204: 5199: 5198: 5196: 5192: 5186: 5183: 5181: 5178: 5176: 5173: 5171: 5168: 5166: 5163: 5162: 5160: 5156: 5150: 5147: 5145: 5144:Enzyme family 5142: 5140: 5137: 5135: 5132: 5131: 5129: 5125: 5119: 5116: 5114: 5111: 5109: 5108:Cooperativity 5106: 5104: 5101: 5100: 5098: 5094: 5088: 5085: 5083: 5080: 5078: 5075: 5073: 5070: 5068: 5067:Oxyanion hole 5065: 5063: 5060: 5058: 5055: 5053: 5050: 5049: 5047: 5043: 5039: 5032: 5027: 5025: 5020: 5018: 5013: 5012: 5009: 4997: 4994: 4992: 4989: 4987: 4984: 4982: 4979: 4977: 4974: 4971: 4967: 4964: 4962: 4959: 4958: 4956: 4953: 4949: 4943: 4940: 4938: 4935: 4934: 4932: 4929: 4925: 4921: 4915: 4912: 4911: 4909: 4907: 4903: 4899: 4893: 4890: 4888: 4885: 4883: 4880: 4879: 4877: 4874: 4873:BH4 dependent 4870: 4866: 4862: 4856: 4853: 4851: 4848: 4846: 4843: 4842: 4840: 4838: 4834: 4830: 4824: 4821: 4819: 4816: 4814: 4811: 4810: 4808: 4806: 4802: 4798: 4794: 4788: 4785: 4783: 4780: 4778: 4775: 4773: 4770: 4768: 4765: 4761: 4758: 4756: 4753: 4751: 4748: 4747: 4746: 4743: 4739: 4736: 4734: 4731: 4729: 4726: 4724: 4721: 4719: 4716: 4715: 4714: 4711: 4710: 4708: 4706: 4702: 4698: 4694: 4686: 4683: 4681: 4678: 4677: 4676: 4673: 4671: 4668: 4664: 4661: 4657: 4654: 4652: 4649: 4647: 4644: 4643: 4642: 4639: 4638: 4637: 4634: 4633: 4631: 4629: 4625: 4621: 4616: 4612: 4608: 4604: 4597: 4592: 4590: 4585: 4583: 4578: 4577: 4574: 4562: 4561: 4557: 4555: 4554: 4550: 4547: 4546: 4543: 4537: 4531: 4529: 4523: 4521: 4518: 4516: 4513: 4511: 4508: 4506: 4503: 4501: 4500:Linoleic acid 4498: 4495: 4494: 4492: 4488: 4478: 4475: 4473: 4470: 4468: 4465: 4463: 4460: 4458: 4455: 4453: 4450: 4448: 4445: 4443: 4440: 4438: 4435: 4433: 4430: 4428: 4425: 4423: 4420: 4418: 4415: 4413: 4410: 4408: 4405: 4403: 4400: 4399: 4397: 4392: 4386: 4382: 4378: 4373: 4363: 4359: 4355: 4350: 4344: 4340: 4336: 4331: 4325: 4318: 4314: 4310: 4306: 4303: 4301: 4298: 4297: 4295: 4290: 4280: 4274: 4271: 4269: 4266: 4264: 4261: 4259: 4256: 4254: 4251: 4249: 4246: 4244: 4241: 4239: 4236: 4234: 4231: 4229: 4226: 4224: 4221: 4219: 4216: 4214: 4211: 4209: 4206: 4204: 4201: 4199: 4196: 4194: 4191: 4189: 4182: 4180: 4177: 4175: 4172: 4170: 4167: 4165: 4162: 4160: 4157: 4155: 4152: 4150: 4147: 4145: 4142: 4140: 4137: 4135: 4132: 4130: 4127: 4125: 4122: 4120: 4117: 4113: 4110: 4108: 4105: 4103: 4100: 4098: 4095: 4093: 4090: 4088: 4085: 4083: 4080: 4078: 4075: 4073: 4070: 4068: 4065: 4063: 4060: 4058: 4055: 4053: 4050: 4048: 4045: 4041: 4038: 4036: 4033: 4031: 4028: 4026: 4023: 4021: 4018: 4016: 4013: 4011: 4008: 4004: 4001: 3999: 3996: 3992: 3989: 3987: 3984: 3982: 3979: 3975: 3972: 3970: 3969:Fluproquazone 3967: 3966:Quinazolines: 3963: 3960: 3958: 3955: 3953: 3950: 3946: 3943: 3941: 3938: 3936: 3933: 3931: 3928: 3926: 3923: 3921: 3918: 3916: 3913: 3911: 3908: 3904: 3901: 3899: 3896: 3894: 3891: 3889: 3886: 3884: 3881: 3877: 3874: 3872: 3869: 3867: 3864: 3862: 3859: 3857: 3854: 3852: 3849: 3847: 3844: 3842: 3839: 3837: 3834: 3830: 3827: 3825: 3822: 3820: 3817: 3815: 3812: 3810: 3807: 3805: 3802: 3800: 3797: 3795: 3792: 3790: 3787: 3785: 3782: 3780: 3777: 3775: 3772: 3770: 3767: 3765: 3762: 3760: 3757: 3755: 3752: 3750: 3747: 3745: 3744:Flunoxaprofen 3742: 3740: 3737: 3735: 3732: 3730: 3729:Dexketoprofen 3727: 3725: 3724:Dexindoprofen 3722: 3720: 3717: 3715: 3712: 3710: 3707: 3705: 3702: 3700: 3697: 3695: 3692: 3688: 3685: 3683: 3680: 3678: 3675: 3673: 3670: 3668: 3665: 3663: 3662:Proglumetacin 3660: 3658: 3655: 3653: 3650: 3648: 3645: 3643: 3640: 3638: 3635: 3633: 3630: 3628: 3625: 3623: 3620: 3618: 3615: 3613: 3610: 3608: 3605: 3603: 3600: 3598: 3595: 3593: 3592:Difenpiramide 3590: 3588: 3585: 3583: 3580: 3578: 3575: 3573: 3570: 3568: 3565: 3563: 3560: 3558: 3555: 3553: 3550: 3548: 3545: 3543: 3540: 3538: 3535: 3533: 3530: 3529:Acetic acids: 3526: 3523: 3521: 3518: 3516: 3513: 3511: 3508: 3506: 3503: 3501: 3498: 3496: 3493: 3491: 3488: 3486: 3483: 3481: 3478: 3476: 3473: 3471: 3468: 3466: 3463: 3461: 3458: 3456: 3453: 3451: 3448: 3446: 3443: 3441: 3438: 3435: 3434: 3432: 3430: 3418: 3415: 3411: 3405: 3401: 3391: 3388: 3386: 3383: 3381: 3378: 3376: 3373: 3371: 3368: 3366: 3363: 3361: 3358: 3356: 3353: 3351: 3348: 3346: 3343: 3341: 3338: 3336: 3333: 3331: 3328: 3326: 3323: 3321: 3318: 3316: 3313: 3311: 3308: 3306: 3303: 3301: 3298: 3296: 3293: 3291: 3288: 3286: 3283: 3281: 3278: 3276: 3273: 3271: 3268: 3266: 3263: 3261: 3260:Fenprostalene 3258: 3256: 3253: 3251: 3248: 3246: 3243: 3241: 3238: 3236: 3233: 3231: 3228: 3226: 3223: 3221: 3218: 3216: 3213: 3211: 3210:Delprostenate 3208: 3206: 3203: 3201: 3198: 3196: 3193: 3191: 3188: 3186: 3183: 3182: 3180: 3176: 3170: 3167: 3165: 3162: 3160: 3157: 3155: 3152: 3150: 3147: 3145: 3142: 3140: 3137: 3135: 3132: 3130: 3127: 3125: 3122: 3120: 3117: 3115: 3109: 3107: 3104: 3102: 3099: 3097: 3094: 3092: 3089: 3087: 3084: 3082: 3079: 3077: 3074: 3072: 3069: 3067: 3064: 3062: 3059: 3057: 3054: 3052: 3049: 3047: 3044: 3042: 3039: 3037: 3034: 3032: 3029: 3027: 3024: 3022: 3019: 3017: 3014: 3012: 3009: 3007: 3004: 3001: 3000: 2997: 2994: 2992: 2989: 2987: 2983:Thromboxane A 2981: 2979: 2976: 2974: 2968: 2965: 2964: 2962: 2957: 2947: 2941: 2938: 2935: 2934: 2931: 2928: 2926: 2923: 2921: 2918: 2916: 2913: 2911: 2908: 2906: 2905:(alprostadil) 2899: 2897: 2890: 2888: 2885: 2883: 2880: 2878: 2875: 2873: 2870: 2868: 2865: 2863: 2860: 2858: 2855: 2853: 2850: 2848: 2845: 2843: 2840: 2837: 2836: 2834: 2829: 2819: 2813: 2810: 2808: 2805: 2803: 2800: 2798: 2795: 2793: 2786: 2784: 2778: 2776: 2773: 2771: 2768: 2766: 2763: 2761: 2758: 2756: 2753: 2751: 2748: 2746: 2743: 2740: 2739: 2737: 2732: 2722: 2712: 2709: 2707: 2704: 2702: 2695: 2693: 2690: 2688: 2685: 2683: 2680: 2678: 2675: 2673: 2670: 2668: 2665: 2663: 2657: 2654: 2653: 2651: 2647: 2641: 2638: 2636: 2633: 2631: 2628: 2626: 2623: 2620: 2619: 2616: 2613: 2611: 2604: 2602: 2601:(alprostadil) 2595: 2593: 2590: 2588: 2585: 2582: 2581: 2579: 2574: 2565: 2559: 2556: 2553: 2552: 2549: 2546: 2544: 2541: 2539: 2536: 2534: 2527: 2525: 2524:(alprostadil) 2518: 2516: 2510: 2508: 2505: 2503: 2500: 2498: 2495: 2493: 2490: 2488: 2485: 2483: 2480: 2478: 2475: 2473: 2470: 2467: 2466: 2464: 2459: 2450: 2444: 2441: 2439: 2436: 2434: 2431: 2428: 2427: 2424: 2421: 2419: 2412: 2410: 2409:(alprostadil) 2403: 2401: 2398: 2396: 2393: 2390: 2389: 2387: 2382: 2373: 2367: 2364: 2362: 2359: 2357: 2354: 2352: 2349: 2347: 2344: 2341: 2340: 2337: 2334: 2332: 2325: 2323: 2322:(alprostadil) 2316: 2314: 2311: 2309: 2306: 2304: 2301: 2299: 2296: 2294: 2291: 2289: 2286: 2283: 2282: 2280: 2275: 2266: 2263: 2258: 2248: 2238: 2235: 2233: 2230: 2228: 2225: 2223: 2220: 2218: 2215: 2213: 2210: 2208: 2205: 2203: 2200: 2198: 2195: 2193: 2190: 2188: 2185: 2183: 2180: 2177: 2176: 2173: 2167: 2165: 2162: 2159: 2158: 2156: 2151: 2142: 2136: 2133: 2131: 2128: 2126: 2123: 2120: 2119: 2116: 2113: 2111: 2105: 2102: 2101: 2099: 2094: 2085: 2082: 2077: 2067: 2064: 2060: 2054: 2050: 2046: 2043: 2040: 2033: 2028: 2026: 2021: 2019: 2014: 2013: 2010: 1998: 1995: 1994: 1992: 1988: 1982: 1979: 1977: 1974: 1972: 1971:LTC4 synthase 1969: 1968: 1965: 1962: 1961: 1958: 1954: 1951: 1950: 1948: 1946: 1942: 1936: 1933: 1932: 1929: 1928:PGI2 synthase 1926: 1925: 1922: 1919: 1917: 1914: 1913: 1910: 1909:PGD2 synthase 1907: 1906: 1901: 1898: 1896: 1893: 1892: 1891: 1888: 1887: 1885: 1883: 1879: 1873: 1870: 1868: 1865: 1864: 1861: 1858: 1857: 1855: 1851: 1847: 1843: 1839: 1835: 1828: 1823: 1821: 1816: 1814: 1809: 1808: 1805: 1799: 1796: 1794: 1791: 1789: 1786: 1783: 1779: 1776: 1774: 1771: 1770: 1758: 1754: 1749: 1744: 1740: 1736: 1733:(3): 566–78. 1732: 1728: 1724: 1717: 1709: 1705: 1701: 1697: 1693: 1689: 1681: 1673: 1669: 1664: 1659: 1655: 1651: 1647: 1643: 1639: 1632: 1624: 1620: 1616: 1612: 1608: 1604: 1600: 1596: 1592: 1585: 1577: 1573: 1569: 1565: 1561: 1554: 1546: 1542: 1538: 1534: 1530: 1526: 1519: 1511: 1507: 1502: 1497: 1492: 1487: 1483: 1479: 1475: 1468: 1466: 1457: 1453: 1449: 1445: 1441: 1437: 1430: 1422: 1418: 1414: 1410: 1407:(5): 386–90. 1406: 1402: 1401:Phytomedicine 1395: 1387: 1383: 1379: 1375: 1371: 1367: 1360: 1351: 1345: 1340: 1334: 1328: 1320: 1316: 1312: 1308: 1304: 1300: 1297:(6): 439–54. 1296: 1292: 1285: 1277: 1273: 1269: 1265: 1260: 1255: 1251: 1247: 1240: 1233: 1225: 1221: 1216: 1211: 1207: 1203: 1199: 1192: 1185: 1180: 1174: 1170: 1166: 1162: 1157: 1156: 1147: 1145: 1136: 1132: 1128: 1124: 1120: 1116: 1112: 1108: 1104: 1100: 1092: 1088: 1082: 1080: 1071: 1067: 1063: 1059: 1055: 1051: 1047: 1043: 1039: 1035: 1028: 1024: 1018: 1014: 1005: 1002: 999: 996: 994: 991: 989: 986: 985: 979: 971: 969: 965: 964:cod liver oil 960: 956: 954: 950: 946: 942: 937: 927: 923: 921: 917: 913: 911: 907: 905: 901: 900:prostacyclins 897: 893: 891: 888:A variety of 886: 884: 874: 872: 868: 864: 860: 856: 852: 848: 844: 840: 836: 826: 823: 819: 818:prostaglandin 814: 812: 806: 796: 790: 782: 778: 768: 766: 762: 758: 754: 744: 742: 738: 734: 730: 726: 722: 718: 713: 711: 707: 703: 699: 695: 691: 687: 683: 679: 675: 671: 667: 665: 661: 657: 653: 649: 645: 641: 637: 633: 629: 626: 622: 618: 614: 610: 606: 602: 590: 587: 583: 580: 577: 573: 568: 564: 561: 560: 556: 553: 551: 547: 544: 541: 539: 535: 530: 527: 524: 522: 518: 515: 512: 510: 506: 503: 500: 498: 494: 491: 488: 486: 482: 479: 476: 474: 470: 467: 464: 462: 458: 454: 450: 447: 444: 440: 435: 428: 423: 420: 416: 405: 402: 398: 395: 392: 388: 383: 379: 376: 375: 371: 368: 366: 362: 359: 356: 354: 350: 345: 342: 339: 337: 333: 330: 327: 325: 321: 318: 315: 313: 309: 306: 303: 301: 297: 294: 291: 289: 285: 282: 279: 277: 273: 269: 265: 262: 259: 255: 250: 246: 240: 235: 232: 228: 217: 214: 212: 208: 205: 202: 200: 196: 193: 190: 188: 184: 179: 175: 172: 168: 165: 163: 162:Gene Ontology 159: 156: 153: 150: 147: 144: 140: 137: 134: 132: 128: 125: 122: 120: 116: 113: 110: 108: 104: 101: 100:NiceZyme view 98: 96: 92: 89: 86: 84: 80: 77: 74: 72: 68: 63: 60: 57: 55: 51: 48: 45: 43: 39: 34: 29: 24: 16: 5281:Translocases 5278: 5265: 5252: 5239: 5226: 5216:Transferases 5213: 5200: 5057:Binding site 4960: 4805:flavoprotein 4609:, including 4607:dioxygenases 4558: 4551: 4496: 4115: 4043: 4040:Propacetamol 4030:Parapropamol 4006: 3994: 3977: 3965: 3957:Floctafenine 3948: 3906: 3883:Azapropazone 3880:Pyrazolones: 3879: 3832: 3814:Tarenflurbil 3749:Flurbiprofen 3719:Dexibuprofen 3699:Benoxaprofen 3694:Alminoprofen 3690: 3617:Glucametacin 3528: 3505:Salicylamide 3495:Salacetamide 3436: 3420: 3385:Trimoprostil 3380:Tiprostanide 3365:Spiriprostil 3300:Naxaprostene 3250:Esuberaprost 3205:Cobiprostone 3003:Antagonists: 3002: 2966: 2937:Antagonists: 2936: 2930:Treprostinil 2838: 2770:Fluprostenol 2760:Cloprostenol 2741: 2655: 2622:Antagonists: 2621: 2587:Lubiprostone 2583: 2555:Antagonists: 2554: 2468: 2430:Antagonists: 2429: 2423:Treprostinil 2391: 2343:Antagonists: 2342: 2308:Lubiprostone 2284: 2179:Antagonists: 2178: 2160: 2122:Antagonists: 2121: 2115:Treprostinil 2103: 1945:Leukotrienes 1935:TXA synthase 1916:PGE synthase 1889: 1730: 1726: 1716: 1691: 1687: 1680: 1645: 1641: 1631: 1598: 1594: 1584: 1567: 1563: 1553: 1528: 1524: 1518: 1481: 1477: 1439: 1435: 1429: 1404: 1400: 1394: 1369: 1365: 1359: 1350: 1343: 1327: 1294: 1290: 1284: 1249: 1245: 1232: 1205: 1201: 1191: 1182: 1154: 1102: 1098: 1037: 1033: 1017: 977: 961: 957: 933: 924: 914: 908: 894: 887: 880: 865:(brand name 847:heart attack 832: 829:Newer NSAIDs 815: 808: 774: 771:Pharmacology 750: 714: 674:inflammation 668: 655: 644:prostacyclin 634:, including 612: 608: 604: 600: 599: 557: 452:Alt. symbols 372: 267:Alt. symbols 245:flurbiprofen 88:BRENDA entry 15: 5052:Active site 4497:Precursors: 4437:Nicogrelate 4417:Furegrelate 4358:Bimatoprost 4268:Trifenagrel 4258:Tiflamizole 4228:Rutecarpine 4213:Resveratrol 4154:Glimepiride 4119:Anitrazafen 4097:Robenacoxib 4077:Lumiracoxib 4010:Acetanilide 3952:Antrafenine 3910:Ampiroxicam 3804:Pranoprofen 3789:Naproxcinod 3682:Zidometacin 3607:Fenclofenac 3532:Aceclofenac 3470:Ethenzamide 3465:Dipyrocetyl 3360:Rosaprostol 3340:Posaraprost 3325:Penprostene 3315:Ornoprostil 3295:Mexiprostil 3290:Meteneprost 3245:Eptaloprost 3220:Dimoxaprost 3185:Arbaprostil 3139:Seratrodast 3031:BMS-180,291 2862:Carbacyclin 2812:Unoprostone 2792:(dinoprost) 2775:Latanoprost 2750:Bimatoprost 2745:Alfaprostol 2701:(dinoprost) 2640:ONO-AE3-208 2592:Misoprostol 2548:Sulprostone 2538:Remiprostol 2507:Misoprostol 2502:Latanoprost 2477:Carbacyclin 2438:PF-04418948 2400:Misoprostol 2336:Sulprostone 2313:Misoprostol 2303:Latanoprost 2237:Vidupiprant 2227:Timapiprant 2222:Setipiprant 2197:Fevipiprant 2164:Indometacin 2135:Vidupiprant 2130:Laropiprant 1882:Prostanoids 1844:metabolism 859:thromboxane 822:thromboxane 789:hydrophobic 717:root symbol 706:paracetamol 636:thromboxane 632:prostanoids 579:Swiss-model 437:Identifiers 394:Swiss-model 252:Identifiers 76:IntEnz view 36:Identifiers 5345:EC 1.14.99 5324:Categories 5255:Isomerases 5229:Hydrolases 5096:Regulation 4937:Tyrosinase 4904:: reduced 4867:: reduced 4835:: reduced 4799:: reduced 4467:Samixogrel 4462:Rolafagrel 4447:Picotamide 4427:Midazogrel 4402:Camonagrel 4263:Timegadine 4208:Pamicogrel 4179:Licofelone 4159:Hyperforin 4124:Clobuzarit 4112:Valdecoxib 4107:Tilmacoxib 4092:Polmacoxib 4067:Etoricoxib 4035:Phenacetin 4003:Nimesulide 3981:Clonixeril 3974:Proquazone 3930:Lornoxicam 3829:Vedaprofen 3779:Miroprofen 3774:Loxoprofen 3769:Ketoprofen 3764:Indoprofen 3739:Fenoprofen 3652:Oxametacin 3647:Nabumetone 3587:Diclofenac 3582:Clometacin 3577:Cinmetacin 3572:Bumadizone 3552:Alclofenac 3537:Acemetacin 3475:Guacetisal 3460:Diflunisal 3410:inhibitors 3375:Tilsuprost 3355:Rivenprost 3350:Rioprostil 3345:Prostalene 3330:Pimilprost 3320:Oxoprostol 3310:Nocloprost 3285:Luprostiol 3275:Lanproston 3270:Froxiprost 3265:Flunoprost 3255:Etiproston 3240:Enisoprost 3235:Eganoprost 3195:Ciprostene 3164:Terutroban 3154:Sulotroban 3134:Samixogrel 3119:Ramatroban 3106:Picotamide 3091:Mipitroban 3086:Linotroban 3071:Imitrodast 3061:ICI-192605 3056:ICI-185282 3041:Domitroban 3021:Argatroban 2920:Taprostene 2842:ACT-333679 2807:Travoprost 2802:Tafluprost 2797:Sulotroban 2755:Carboprost 2711:Taprenepag 2692:Omidenepag 2687:Nocloprost 2677:Evatanepag 2672:Carboprost 2625:Grapiprant 2217:Ramatroban 2125:Asapiprant 2045:modulators 2039:Prostanoid 1842:eicosanoid 1834:Metabolism 1484:(1): 202. 1010:References 951:, but not 945:diclofenac 916:Calcitriol 910:Hyperforin 890:flavonoids 851:thrombosis 839:etoricoxib 803:See also: 777:isoleucine 767:membrane. 575:Structures 570:Search for 559:q25.2-25.3 532:Other data 390:Structures 385:Search for 347:Other data 145:structures 112:KEGG entry 59:9055-65-6 5134:EC number 4906:ascorbate 4869:pteridine 4472:Terbogrel 4452:Pirmagrel 4412:Dazoxiben 4407:Dazmegrel 4300:Retinoids 4218:Romazarit 4164:Itazigrel 4149:FR-122047 4144:Flumizole 4102:Rofecoxib 4087:Parecoxib 4082:Mavacoxib 4072:Firocoxib 4062:Deracoxib 4057:Cimicoxib 4052:Celecoxib 4047:Apricoxib 3998:Flosulide 3962:Glafenine 3945:Tenoxicam 3940:Piroxicam 3935:Meloxicam 3819:Tepoxalin 3799:Pirprofen 3794:Oxaprozin 3759:Ibuproxam 3754:Ibuprofen 3714:Carprofen 3709:Butibufen 3687:Zomepirac 3657:Oxindanac 3642:Mofezolac 3637:Lonazolac 3632:Ketorolac 3612:Fentiazac 3567:Bufexamac 3562:Bromfenac 3542:Aclofenac 3525:Triflusal 3515:Salsalate 3440:Aloxiprin 3390:Viprostol 3335:Piriprost 3305:Nileprost 3280:Limaprost 3230:Ecraprost 3225:Doxaprost 3215:Deprostil 3200:Clinprost 3159:Terbogrel 3149:SQ-29,548 3144:SQ-28,668 3101:ONO-11120 3066:Ifetroban 3036:Daltroban 3026:Bay U3405 2996:Vapiprost 2967:Agonists: 2940:RO1138452 2915:Selexipag 2910:Ralinepag 2867:Cicaprost 2857:BMY-45778 2852:Beraprost 2839:Agonists: 2765:Enprostil 2742:Agonists: 2706:Simenepag 2682:Gemeprost 2656:Agonists: 2630:GW-627368 2584:Agonists: 2487:Enprostil 2482:Cicaprost 2472:Beraprost 2469:Agonists: 2395:Butaprost 2392:Agonists: 2293:Enprostil 2288:Beraprost 2285:Agonists: 2192:Bay U3405 2161:Agonists: 2104:Agonists: 2042:signaling 1990:Ungrouped 1853:Precursor 1094:​; 1030:​; 949:ibuprofen 926:aspirin. 920:vitamin D 896:Fish oils 871:celecoxib 863:Rofecoxib 835:celecoxib 765:microsome 763:(ER) and 690:ibuprofen 628:1.14.99.1 615:), is an 543:1.14.99.1 538:EC number 514:NM_000963 461:NCBI gene 374:q32-q33.3 358:1.14.99.1 353:EC number 329:NM_080591 276:NCBI gene 65:Databases 47:1.14.99.1 5158:Kinetics 5082:Cofactor 5045:Activity 4548:See also 4457:Ridogrel 4432:Nafagrel 4422:Isbogrel 4305:Selenium 4273:Tropesin 4248:SC-58125 4233:Satigrel 4198:NCX-4040 4174:L-670596 4169:L-655240 4129:Curcumin 3991:Flunixin 3986:Clonixin 3925:Isoxicam 3920:Enolicam 3915:Droxicam 3893:Isopyrin 3888:Dipyrone 3809:Suprofen 3784:Naproxen 3734:Fenbufen 3677:Tolmetin 3667:Sulindac 3602:Felbinac 3597:Etodolac 3557:Bendazac 3370:Tiaprost 3190:Ataprost 3178:Unsorted 3124:Ridogrel 3096:ONO-3708 3081:L-670596 3076:L-655240 3051:GR-32191 2667:Aganepag 2649:Unsorted 2635:L-161982 2615:TCS-2510 2558:L-798106 2443:TG 4-155 2366:SC-51322 2361:SC-51089 2356:SC-19220 2351:ONO-8130 2187:AZD-1981 2182:ADC-3680 2053:Receptor 1757:22097969 1708:27959716 1672:16740558 1615:18923189 1576:16886660 1545:12445866 1510:16542466 1456:15225597 1421:12834003 1386:12475274 1311:11081405 1276:10837155 1268:15987694 1224:17462992 982:See also 953:naproxen 729:proteins 721:genetics 642:such as 621:isozymes 589:InterPro 404:InterPro 216:proteins 204:articles 192:articles 149:RCSB PDB 5314:Biology 5268:Ligases 5038:Enzymes 4952:1.14.99 4930:: other 4924:1.14.18 4902:1.14.17 4865:1.14.16 4833:1.14.15 4797:1.14.14 4697:1.14.13 4624:1.14.11 4477:U63557A 4442:Ozagrel 4253:Tenidap 4193:NCX-466 4139:FK-3311 4134:DuP-697 4020:Bucetin 3547:Amfenac 3500:Salicin 3169:TRA-418 3016:AA-2414 3006:12-HETE 2991:U-46619 2925:TRA-418 2882:MRE-269 2433:AH-6809 2346:AH-6809 2232:TM30089 2212:QAV-680 2207:MK-7246 2202:MK-1029 2059:ligands 1846:enzymes 1748:3288221 1663:1473048 1501:1526555 1344:UniProt 1319:6317524 1163:–1568. 1135:4326310 1127:8967954 1107:Bibcode 1070:4340064 1062:8121489 1042:Bibcode 883:maitake 747:Biology 686:aspirin 646:, from 585:Domains 521:UniProt 400:Domains 336:UniProt 171:QuickGO 136:profile 119:MetaCyc 54:CAS no. 5300:Portal 5242:Lyases 4801:flavin 4680:ALKBH1 4490:Others 4339:HQL-79 4243:SC-560 4238:SC-236 4203:NS-398 3404:Enzyme 3046:EP-045 3011:13-APA 2951:TP (TX 2887:NS-304 2847:AFP-07 1784:(MeSH) 1755:  1745:  1706:  1694:(26). 1670:  1660:  1623:448875 1621:  1613:  1574:  1543:  1508:  1498:  1454:  1419:  1384:  1339:P35354 1333:P23219 1317:  1309:  1274:  1266:  1222:  1175:  1133:  1125:  1099:Nature 1068:  1060:  1034:Nature 855:stroke 853:, and 781:valine 617:enzyme 555:Chr. 1 526:P35354 509:RefSeq 490:600262 442:Symbol 370:Chr. 9 341:P23219 324:RefSeq 305:176805 257:Symbol 199:PubMed 181:Search 167:AmiGO 155:PDBsum 95:ExPASy 83:BRENDA 71:IntEnz 42:EC no. 5194:Types 4970:HMOX1 4705:NADPH 4663:P4HTM 4656:EGLN3 4651:EGLN2 4646:EGLN1 4617:1.14) 3129:S-145 2978:I-BOP 2823:IP (I 2726:FP (F 2252:EP (E 2071:DP (D 1900:PTGS2 1895:PTGS1 1619:S2CID 1315:S2CID 1272:S2CID 1242:(PDF) 1131:S2CID 1066:S2CID 867:Vioxx 741:PTGS2 737:PTGS1 725:genes 704:) of 702:AM404 694:COX-2 550:Locus 455:COX-2 446:PTGS2 365:Locus 270:COX-1 261:PTGS1 131:PRIAM 5286:list 5279:EC7 5273:list 5266:EC6 5260:list 5253:EC5 5247:list 5240:EC4 5234:list 5227:EC3 5221:list 5214:EC2 5208:list 5201:EC1 4986:21A2 4981:17A1 4855:11A1 4850:11B2 4845:11B1 4813:19A1 4760:NOS3 4755:NOS2 4750:NOS1 4738:FMO5 4733:FMO4 4728:FMO3 4723:FMO2 4718:FMO1 4701:NADH 4675:AlkB 4390:TXAS 4348:PGFS 4329:PGES 3427:PTGS 1997:HPGD 1753:PMID 1704:PMID 1688:NEJM 1668:PMID 1611:PMID 1572:PMID 1541:PMID 1506:PMID 1452:PMID 1417:PMID 1382:PMID 1307:PMID 1264:PMID 1220:PMID 1173:ISBN 1161:1553 1123:PMID 1091:6COX 1058:PMID 1027:1CQE 947:and 820:and 739:and 727:and 688:and 678:pain 676:and 638:and 613:PTGS 502:6COX 485:OMIM 478:9605 473:HGNC 466:5743 317:1CQE 300:OMIM 293:9604 288:HGNC 281:5742 211:NCBI 152:PDBe 107:KEGG 4823:2E1 4818:2D6 4803:or 4777:3A4 4703:or 4685:FTO 4367:PGI 4284:PGD 3422:COX 1743:PMC 1735:doi 1696:doi 1692:375 1658:PMC 1650:doi 1646:332 1642:BMJ 1603:doi 1533:doi 1496:PMC 1486:doi 1444:doi 1440:551 1409:doi 1374:doi 1299:doi 1254:doi 1250:280 1210:doi 1206:282 1165:doi 1115:doi 1103:384 1087:PDB 1050:doi 1038:367 1023:PDB 793:523 785:523 605:COX 497:PDB 312:PDB 187:PMC 143:PDB 5326:: 4928:19 4699:: 4626:: 4615:EC 4605:: 4315:, 4311:, 4114:; 4042:; 4005:; 3993:; 3976:; 3964:; 3947:; 3905:; 3878:; 3831:; 3689:; 3527:; 2953:A2 2790:2α 2728:2α 2699:2α 2569:EP 2454:EP 2377:EP 2270:EP 2146:DP 2089:DP 1840:– 1836:: 1751:. 1741:. 1731:27 1729:. 1725:. 1702:. 1690:. 1666:. 1656:. 1644:. 1640:. 1617:. 1609:. 1599:88 1597:. 1593:. 1568:26 1566:. 1562:. 1539:. 1529:64 1527:. 1504:. 1494:. 1480:. 1476:. 1464:^ 1450:. 1438:. 1415:. 1405:10 1403:. 1380:. 1370:50 1368:. 1342:. 1336:, 1313:. 1305:. 1295:29 1293:. 1270:. 1262:. 1248:. 1244:. 1218:. 1204:. 1200:. 1181:. 1171:. 1143:^ 1129:. 1121:. 1113:. 1101:. 1089:: 1078:^ 1064:. 1056:. 1048:. 1036:. 1025:: 906:. 849:, 837:, 813:. 753:Da 680:. 625:EC 623:, 169:/ 5302:: 5288:) 5284:( 5275:) 5271:( 5262:) 5258:( 5249:) 5245:( 5236:) 5232:( 5223:) 5219:( 5210:) 5206:( 5030:e 5023:t 5016:v 4972:) 4968:( 4926:- 4875:) 4871:( 4613:( 4595:e 4588:t 4581:v 4535:2 4527:2 4371:S 4369:2 4319:) 4307:( 4288:S 4286:2 4188:) 4186:2 3429:) 3425:( 3412:) 3408:( 3113:2 2985:2 2972:2 2955:) 2903:1 2894:2 2827:) 2825:2 2782:2 2730:) 2661:2 2608:2 2599:1 2571:4 2531:2 2522:1 2514:2 2456:3 2416:2 2407:1 2379:2 2329:2 2320:1 2272:1 2256:) 2254:2 2171:2 2148:2 2109:2 2091:1 2075:) 2073:2 2061:) 2057:( 2031:e 2024:t 2017:v 1955:/ 1826:e 1819:t 1812:v 1759:. 1737:: 1710:. 1698:: 1674:. 1652:: 1625:. 1605:: 1578:. 1547:. 1535:: 1512:. 1488:: 1482:8 1458:. 1446:: 1423:. 1411:: 1388:. 1376:: 1321:. 1301:: 1278:. 1256:: 1226:. 1212:: 1167:: 1137:. 1117:: 1109:: 1072:. 1052:: 1044:: 918:( 611:( 603:( 25:.

Index

Cox (disambiguation)
EC no.
1.14.99.1
CAS no.
9055-65-6
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB
RCSB PDB
PDBe
PDBsum
Gene Ontology
AmiGO
QuickGO
PMC
articles
PubMed
articles
NCBI
proteins

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