1311:
1297:
1304:
1290:
719:
696:
1331:
of celecoxib, it is necessary to analyze the free energy of binding difference between the drug molecule and COX-1 compared to COX-2 enzymes. The structural modifications highlight the importance of binding to residue 523 in the side binding pocket of the cyclooxygenase enzyme, which is an isoleucine in COX-1 and a valine in COX-2. This mutation appears to contribute to COX-2 selectivity by creating steric hindrance between the sulfonamide oxygen and the methyl group of Ile523 that effectively destabilizes the celecoxib-COX-1 complex.
40:
1092:, the elderly or debilitated patients. Use the lowest effective dose for the shortest duration of time, consistent with individual patient goals, to reduce risk of GI adverse events; alternate therapies should be considered for patients at high risk. When used concomitantly with ≤325 mg of aspirin, a substantial increase in the risk of gastrointestinal complications (e.g., ulcer) occurs; concomitant gastroprotective therapy (e.g., proton pump inhibitors) is recommended. The increased risk is about 81%.
7444:
7464:
31:
1511:) had been fabricated. The analgesic effects of the drugs had been exaggerated. Reuben was also a former paid spokesperson for Pfizer. Although from 2002 to 2007 Pfizer underwrote much of Dr. Reuben's research and "many of his trials found that Celebrex and Lyrica, Pfizer drugs, were effective against postoperative pain," Pfizer was not aware of the fraudulent data. None of the retracted studies were submitted to either the US
7454:
11502:
1250:
the protection of the gastrointestinal mucosa, kidney hemodynamics, and platelet thrombogenesis. COX-2, on the contrary, is extensively expressed in cells involved in inflammation and is upregulated by bacterial lipopolysaccharides, cytokines, growth factors, and tumor promoters. Celecoxib is approximately 10-20 times more selective for COX-2 inhibition over COX-1. It binds with its polar
2568:
2525:
1158:
result in poor cardiovascular outcomes than treatment with naproxen or ibuprofen. As a result, in 2018 an FDA advisory panel concluded that celecoxib poses no greater risk for causing heart attacks and strokes than the commonly-used NSAIDs ibuprofen or naproxen and recommended that the FDA consider changing its advice to physicians regarding celecoxib's safety.
1318:
para-sulfamoylphenyl at position 1 of the pyrazole was found to have a higher potency for COX-2 selective inhibition than a para-methoxyphenyl (see structures 1 and 2, below). In addition, a 4-(methylsulfonyl)phenyl or 4-sulfamoylphenyl is known to be necessary for COX-2 inhibition. For instance, replacing either of these entities with a –SO
1614:
the laboratory, it became apparent that celecoxib could interact with other intracellular components besides its most famous target, COX-2. The discovery of these additional targets has generated much controversy, and the initial assumption that celecoxib reduces tumor growth primarily by the inhibition of COX-2 became contentious.
1084:
cardiovascular risk in children has not been evaluated. Use the lowest effective dose for the shortest duration of time, consistent with individual patient goals, to reduce risk of cardiovascular events; alternative therapies should be considered for patients at high risk. The increased risk is about 37%.
1179:
found that cardiovascular effects of COX-2 inhibitors differ, depending on the drug. Other COX-2-selective inhibitors, such as rofecoxib, have significantly higher myocardial infarction rates than celecoxib. In April 2005, after an extensive review of data, the FDA concluded it was likely "that there
1169:
warned that with respect to "patients with a prior history of or at high risk for cardiovascular disease... use of COX-2 inhibitors for pain relief should be limited to patients for whom there are no appropriate alternatives, and then, only in the lowest dose and for the shortest duration necessary."
1613:
Different from cancer prevention, cancer treatment is focused on the therapy of tumors that have already formed and have established themselves inside the patient. Many studies are going on to determine whether celecoxib might be useful for this latter condition. However, during molecular studies in
1445:
of
Celebrex soon afterwards. Sales reached $ 2 billion in 2006. Prior to its availability in generic form, it was one of Pfizer's "best-selling drugs, amounting to more than $ 2.5 billion in sales , and was prescribed to 2.4 million" people in 2011. By 2012, 33 million Americans had taken celecoxib.
1330:
Celecoxib is compound 22; the 4-sulfamoylphenyl on the 1-pyrazol substituent is required for COX-2 inhibition and the 4-methyl on the 5-pyrazol system has low steric hindrance to maximize potency, while the 3-trifluoromethyl group provides superior selectivity and potency. To explain the selectivity
1249:
and COX-2. Inhibition of COX-1 (which celecoxib does not inhibit at therapeutic concentrations) inhibits the production of prostaglandins and the production of thromboxane A2, a platelet activator. COX-1 is traditionally defined as a constitutively expressed "housekeeping" enzyme and plays a role in
1204:, which can greatly elevate celecoxib serum levels. If used concomitantly with lithium, celecoxib increases lithium plasma levels. If used concomitantly with warfarin, celecoxib may result in increased risk of bleeding complications. The risk of bleeding and gastric ulcers also increase further when
1136:
moiety and may cause allergic reactions in those allergic to other sulfonamide-containing drugs. This is in addition to the contraindication in people with severe allergies to other NSAIDs. However, it has a low (reportedly 4%) chance of inducing cutaneous reactions among persons who have a history
1074:
Cardiovascular events: NSAIDs are associated with an increased risk of serious (and potentially fatal) adverse cardiovascular thrombotic events, including myocardial infarction and stroke. Risk may be increased with duration of use or pre-existing cardiovascular risk factors or disease. Individual
1487:
presented findings from their study that
Celebrex was "better in protecting the stomach from serious complications than other drugs." This became Celebrex's main selling point. However, following federal investigations it was revealed that Pfizer and Pharmacia "only presented the results from the
1317:
The Searle research group found the two appropriately substituted aromatic rings must reside on adjacent positions about the central ring for adequate COX-2 inhibition. Various modifications can be made to the 1,5-diarylpyrazole moiety to deduce the structure-activity relationship of celecoxib. A
1157:
A 2013 meta-analysis of hundreds of clinical trials found that coxibs (the class of drugs that includes celecoxib) increase the risk of major cardiovascular problems by about 37% over placebo. In 2016, a randomized trial provided strong evidence that treatment with celecoxib is not more likely to
1527:
It is legally available in many jurisdictions as a generic under several brand names. In the US, celecoxib was covered by three patents, two of which expired on 30 May 2014, and one of which (US RE44048) was due to expire 2 December 2015. On 13 March 2014, that patent was found to be invalid for
1436:
claimed that United States Pat. No. 6,048,850 (which claimed a method of inhibiting COX-2 in humans using a compound, without actually disclosing what that compound might be) covered drugs such as celecoxib. The court ruled in favor of Searle, holding in essence that the university had claimed a
1515:
or the
European Union's regulatory agencies prior to the drug's approval. Although Pfizer issued a public statement declaring, "It is very disappointing to learn about Dr. Scott Reuben's alleged actions. When we decided to support Dr. Reuben's research, he worked for a credible academic medical
1087:
Gastrointestinal events: NSAIDs may increase risk of serious gastrointestinal (GI) ulceration, bleeding, and perforation (may be fatal). These events may occur at any time during therapy and without warning. Use caution with a history of GI disease (bleeding or ulcers), concurrent therapy with
1083:
may occur (NSAIDs may impair response to thiazide or loop diuretics), and may contribute to cardiovascular events; monitor blood pressure and use with caution in patients with hypertension. May cause sodium and fluid retention, use with caution in patients with edema or heart failure. Long-term
1326:
substituent diminishes COX-2 inhibitory activity as noted with a very high inhibitory concentration-50 (see structures 3 – 5). At the 3-position of the pyrazole, a trifluoromethyl or difluoromethyl provides superior selectivity and potency compared to a fluoromethyl or methyl substitution (see
1440:
After the withdrawal of rofecoxib from the market in
September 2004, celecoxib enjoyed a robust increase in sales. However, the results of the APC trial in December of that year raised concerns that Celebrex might carry risks similar to those of rofecoxib, and Pfizer announced a moratorium on
1604:
families) showed celecoxib can prevent polyp growth. Hence, large-scale randomized clinical trials were undertaken. Results show a 33 to 45% polyp recurrence reduction in people treated with celecoxib each day. However, serious cardiovascular events were significantly more frequent in the
3922:
Bartoli F, Cavaleri D, Bachi B, Moretti F, Riboldi I, Crocamo C, et al. (September 2021). "Repurposed drugs as adjunctive treatments for mania and bipolar depression: A meta-review and critical appraisal of meta-analyses of randomized placebo-controlled trials".
1496:(FDA) released the full results of the Pfizer and Pharmacia study which showed that they had withheld crucial data. By 2012, a federal judge unsealed "thousands of pages of internal documents and depositions" in a "long-running securities fraud case against Pfizer."
1423:
from 2000 to 2003. Celecoxib was discovered and developed by G. D. Searle & Company and was approved by the FDA on 31 December 1998. It was co-promoted by
Monsanto Company (parent company of Searle) and Pfizer under the brand name Celebrex. Monsanto merged with
3117:
Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW, Docter S, et al. (April 1997). "Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-benze nesulfonamide (SC-58635, celecoxib)".
1396:, 358 F.3d 916 (Fed. Cir. 2004). The court ruled in favor of Searle in 2004, holding in essence that the university had claimed a method requiring, yet provided no written description of, a compound that could inhibit COX-2 and therefore the patent was invalid.
1388:, and in 2006, BYU sued Pfizer for breach of contract, claiming Pfizer did not properly pay contractual royalties back to BYU. A settlement was reached in April 2012, in which Pfizer agreed to pay $ 450 million. Other important discoveries in COX-2 were made at
1617:
Certainly, the inhibition of COX-2 is paramount for the anti-inflammatory and analgesic function of celecoxib. However, whether inhibition of COX-2 also plays a dominant role in this drug's anticancer effects is unclear. For example, a recent study with
1123:
to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid. They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.
3407:
2553:
3030:"ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents"
4095:
Fond G, Hamdani N, Kapczinski F, Boukouaci W, Drancourt N, Dargel A, et al. (March 2014). "Effectiveness and tolerance of anti-inflammatory drugs' add-on therapy in major mental disorders: a systematic qualitative review".
1605:
celecoxib-treated groups. Aspirin shows a similar (and possibly larger) protective effect, has demonstrated cardioprotective effects and is significantly cheaper, but no head-to-head clinical trials have compared the two drugs.
1245:, celecoxib inhibits the transformation of arachidonic acid to prostaglandin precursors. Therefore, it has analgesic and anti-inflammatory properties. Nonselective NSAIDs (such as aspirin, naproxen, and ibuprofen) inhibit both
1647:
was investigated, the antitumor potency did not at all depend on whether or not the respective compound could inhibit COX-2, showing the inhibition of COX-2 was not required for the anticancer effects. One of these compounds,
2510:
4731:
1428:, from which the Medical Research Division was acquired by Pfizer, giving Pfizer ownership of Celebrex. The drug was at the core of a major patent dispute that was resolved in Searle's favor (later Pfizer) in 2004. In
1165:(Vioxx) was removed from the market in 2004 due to its risk. Like all NSAIDs on the US market, celecoxib carries an FDA-mandated "black box warning" for cardiovascular and gastrointestinal risk. In February 2007, the
1111:
People with prior history of ulcer disease or GI bleeding require special precaution. Moderate to severe liver impairment or GI toxicity can occur with or without warning symptoms in people treated with NSAIDs.
1467:, which called the ad's comparisons misleading. Pfizer responded to Public Citizen's concerns with assurances that they are truthfully advertising the risk and benefits of Celebrex as set forth by the FDA.
3453:
1635:
Additional support for the idea that other targets besides COX-2 are important for celecoxib's anticancer effects has come from studies with chemically modified versions of celecoxib. Several dozen
3403:
1851:
McCormack PL (December 2011). "Celecoxib: a review of its use for symptomatic relief in the treatment of
Osteoarthritis, Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis".
2545:
2097:
1628:, but COX-2 played no role in this outcome; even more strikingly, the anticancer effects of celecoxib were also obtained with the use of cancer cell types that do not even contain COX-2.
3546:
1463:-minute advertisement which extensively discussed the adverse effects of Celebrex in comparison with other anti-inflammatory drugs. The ad drew criticism from the consumer advocacy group
2339:"OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence"
1516:
center and appeared to be a reputable investigator", the documents unsealed in 2012, revealed that by
February 2000, Pharmacia employees had devised a strategy to present the findings.
294:
9577:
4578:
Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA (February 2008). "Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs".
2498:
3365:
3296:
3432:
9888:
3329:
1820:
1552:
On the theory that inflammation plays a role in the pathogenesis of major mental disorders, celecoxib has been trialed for a number of psychiatric disorders, including
1149:; events may occur without warning and in patients without prior known sulfa allergy. Use should be discontinued at first sign of rash (or any other hypersensitivity).
3701:
8948:
3790:
1743:
1274:
For its use in reducing colon polyps, celecoxib affects genes and pathways involved in inflammation and malignant transformation in tumors, but not normal tissues.
6372:
1649:
1340:
797:
4009:
Na KS, Lee KJ, Lee JS, Cho YS, Jung HY (January 2014). "Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: a meta-analysis".
1738:[Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).
10029:
2063:
1643:. Some of these analogs retained COX-2 inhibitory activity, whereas many others did not. However, when the ability of all these compounds to kill tumor cells in
7750:
4694:
Zhang J, Ding EL, Song Y (October 2006). "Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials".
1600:
has been investigated, but neither celecoxib nor any other drug is indicated for this use. Small-scale clinical trials in very high-risk people (belonging to
1254:
to a hydrophilic side pocket region close to the active COX-2 binding site. In theory, this selectivity allows celecoxib and other COX-2 inhibitors to reduce
7447:
239:
4747:
6516:
1960:"Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials"
3449:
10789:
10759:
10590:
3812:
307:
4784:
4145:
2704:"Analysis and recommendations for Agency action regarding nonsteroidal anti-inflammatory drugs and cardiovascular risk [decision memorandum]"
4052:
Rosenblat JD, Cha DS, Mansur RB, McIntyre RS (August 2014). "Inflamed moods: a review of the interactions between inflammation and mood disorders".
9795:
9415:
1524:
Pfizer markets celecoxib under the brand name
Celebrex, and it is available as oral capsules containing 50, 100, 200 or 400 mg of celecoxib.
10642:
10622:
10178:
10128:
6864:
3536:
2089:
1489:
1419:
that led to the development of the anti-inflammatory drug celecoxib (Celebrex). He became senior executive vice president and chief scientist of
10948:
10413:
10303:
10298:
10283:
10218:
10168:
10123:
9688:
8049:
4623:"Antitumor properties of dimethyl-celecoxib, a derivative of celecoxib that does not inhibit cyclooxygenase-2: implications for glioma therapy"
2703:
1584:
It has been used to reduce colon and rectal polyps in people with familial adenomatous polyposis, but it is not known if it decreases rates of
1061:
It has been used to reduce colon and rectal polyps in people with familial adenomatous polyposis, but it is not known if it decreases rates of
3611:
3577:
11537:
11355:
11186:
11176:
10600:
10278:
10258:
10243:
10233:
10213:
10208:
10163:
10138:
10103:
9949:
9780:
9558:
9456:
9395:
9356:
9155:
9145:
9053:
8941:
4678:
3500:
125:
1507:, Springfield, Massachusetts, revealed that the data for 21 studies he had authored for the efficacy of the drug (along with others such as
1095:
Hematologic effects: Anemia may occur; monitor hemoglobin or hematocrit in people on long-term treatment. Celecoxib does not usually affect
11385:
11380:
11345:
11320:
11181:
11042:
10899:
10500:
10495:
10293:
10273:
10268:
10263:
10248:
10238:
10228:
10203:
10193:
10188:
10183:
10173:
10158:
10153:
10113:
10072:
10052:
10009:
10004:
9989:
9979:
9974:
9959:
9838:
9760:
9715:
9629:
9605:
9595:
9043:
6432:
5484:
3644:
811:
11370:
11325:
11136:
11082:
11067:
10916:
10627:
10575:
10460:
10308:
10253:
10223:
10198:
10148:
10143:
10133:
10118:
10067:
10062:
10019:
9954:
9944:
9914:
9858:
9828:
9785:
9775:
9624:
9548:
9400:
9313:
9110:
7997:
7163:
6939:
5313:
5293:
5278:
4504:
3351:
2136:
3288:
11375:
11350:
11340:
11191:
11166:
11151:
11116:
11092:
11087:
10838:
10288:
10108:
10042:
10014:
9999:
9994:
9969:
9585:
9553:
9533:
9476:
9361:
9284:
9279:
9274:
9269:
9105:
9100:
6879:
6839:
6494:
4454:"COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro"
1188:
associated with COX-2 inhibitors were examined, but no significant risks were found when compared to nonselective NSAIDs or placebos.
11478:
11395:
11111:
11057:
11052:
10087:
9934:
9843:
9800:
9351:
9264:
9150:
9130:
9125:
9120:
3156:
Price ML, Jorgensen WL (June 2001). "Rationale for the observed COX-2/COX-1 selectivity of celecoxib from Monte Carlo simulations".
1437:
method requiring, yet provided no written description of, a compound that could inhibit COX-2 and therefore the patent was invalid.
11257:
11161:
11156:
9964:
9929:
9805:
9765:
8934:
7457:
6509:
2014:"Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association"
1053:
Evidence of effects is not clear as a number of studies done by the manufacturer have not been released for independent analysis.
10047:
9896:
3319:
1812:
1773:
3731:
3679:
2956:"A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity"
1449:
Pfizer resumed advertising
Celebrex in magazines in 2006, and resumed television advertising in April 2007 with an unorthodox,
1205:
5700:
3255:
3200:
839:
InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
8892:
7422:
6460:
4777:
3012:
2190:
4141:"Clinical end points for developing pharmaceuticals to manage patients with a sporadic or genetic risk of colorectal cancer"
2733:"Do selective COX-2 inhibitors increase the risk of cerebrovascular events? A meta-analysis of randomized controlled trials"
1929:
1680:
7500:
6525:
3780:
3709:
1735:
8508:
8069:
8037:
7103:
6502:
6067:
4732:"COX-2 Selective (includes Bextra, Celebrex, and Vioxx) and Non-Selective Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)"
1310:
878:
11557:
11542:
5219:
5175:
5053:
1731:
4762:
3757:
2053:
1392:, which patented the discoveries. When the patent issued, the university sued Searle (later Pfizer) in a case called,
4978:
3222:
2895:
2667:
Mukherjee D, Nissen SE, Topol EJ (2001). "Risk of cardiovascular events associated with selective COX-2 inhibitors".
2166:
2130:
1652:, which entirely lacks the ability to inhibit COX-2, actually displayed stronger anticancer activity than celecoxib.
856:
831:
176:
98:
3966:
Müller N, Myint AM, Krause D, Weidinger E, Schwarz MJ (April 2013). "Anti-inflammatory treatment in schizophrenia".
1632:
and colleagues have published research showing antiangiogenic and antitumor activity of celecoxib in animal models.
8909:
6477:
4770:
2499:"FDA Warns that Using a Type of Pain and Fever Medication in Second Half of Pregnancy Could Lead to Complications"
964:. Use is not recommended in people at high risk for heart disease. The risks are similar to other NSAIDs, such as
9924:
5494:
1488:
first six months of a year long study rather than the whole thing." These partial results were then published in
445:
279:
157:
6113:
5115:
5005:
1601:
1442:
1032:
922:
4539:"Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents"
3069:
Half E, Arber N (February 2009). "Colon cancer: preventive agents and the present status of chemoprevention".
516:
11522:
6035:
6018:
5893:
5657:
5035:
1736:"RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial"
1137:
of such reactions to aspirin or nonselective NSAIDs. NSAIDs may cause serious skin adverse events, including
1036:
1028:
914:
11471:
8364:
8007:
5767:
5363:
4753:
4737:
3824:
3818:
3494:
2710:
2504:
1739:
1512:
1493:
1400:
1142:
1116:
949:
714:
567:
4274:"A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer"
2911:
Shi S, Klotz U (March 2008). "Clinical use and pharmacological properties of selective COX-2 inhibitors".
9063:
9006:
5969:
1703:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
1175:
1100:
675:
6524:
5359:
5329:
11562:
11532:
11492:
9486:
9371:
9294:
9187:
8027:
5149:
1166:
1146:
11428:
5254:
636:
11527:
9169:
8988:
6335:
6215:
6205:
2456:"Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention"
2288:"Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials"
1702:
1412:
1208:(SSRI) are used in combination with celecoxib. The drug may increase the risk of kidney failure with
987:. In 2021, it was the 98th most commonly prescribed medication in the United States, with more than 7
953:
3603:
3569:
2714:
11265:
11246:
11201:
9643:
8742:
8703:
7493:
7401:
6387:
6320:
6290:
5908:
5158:
4405:"Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy"
3260:
2628:"Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction"
1532:. Upon the patent expiry on 30 May 2014, the FDA approved the first versions of generic celecoxib.
1377:
691:
3488:
8971:
8897:
8613:
8017:
7673:
7426:
6465:
6190:
5905:
5391:
5239:
5166:
3674:
3634:
1504:
1433:
1389:
1296:
1251:
1185:
1133:
213:
115:
2626:
Kimmel SE, Berlin JA, Reilly M, Jaskowiak J, Kishel L, Chittams J, et al. (February 2005).
11307:
11227:
8661:
7617:
6270:
6260:
5993:
5835:
2585:
Nissen SE, Yeomans ND, Solomon DH, Lüscher TF, Libby P, Husni ME, et al. (December 2016).
1138:
1050:(acetaminophen) at 3990 mg per day, which is the first line treatment for osteoarthritis.
1024:
906:
657:
386:
4503:
Masferrer JL, Leahy KM, Koki AT, Zweifel BS, Settle SL, Woerner BM, et al. (March 2000).
4272:
Sandler RS, Halabi S, Baron JA, Budinger S, Paskett E, Keresztes R, et al. (March 2003).
4190:
Bertagnolli MM, Eagle CJ, Zauber AG, Redston M, Solomon SD, Kim K, et al. (August 2006).
3028:
Bhatt DL, Scheiman J, Abraham NS, Antman EM, Chan FK, Furberg CD, et al. (October 2008).
2834:"Efficacy and Safety of COX-2 Inhibitors in the Clinical Management of Arthritis: Mini Review"
2120:
1380:(BYU) discovered the COX-2 enzyme in 1988, and in 1991, BYU entered into a collaboration with
616:
11552:
11284:
9740:
8977:
8420:
8114:
8032:
8022:
7734:
7677:
7406:
7396:
7391:
7381:
5542:
5189:
3324:
2337:
Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, et al. (September 2007).
1370:
1259:
941:
507:
3846:
2644:
2627:
471:
422:
7.8 hours; 11 hours (mild hepatic impairment); 13 hours (moderate-severe hepatic impairment)
11423:
10545:
10398:
9868:
8631:
8592:
8425:
8415:
8410:
8237:
8042:
7958:
7600:
7376:
7353:
6834:
6706:
5940:
5817:
5338:
2454:
Solomon SD, McMurray JJ, Pfeffer MA, Wittes J, Fowler R, Finn P, et al. (March 2005).
1016:
1004:
910:
898:
576:
414:
9706:
9615:
3868:
1384:
to develop drugs to inhibit it. Monsanto's pharmaceutical division was later purchased by
556:
8:
10373:
8380:
8012:
7841:
7742:
7681:
7568:
7557:
7486:
7430:
7386:
7303:
6681:
6225:
6125:
6104:
5825:
5647:
5479:
5210:
5106:
4231:
Baron JA, Cole BF, Sandler RS, Haile RW, Ahnen D, Bresalier R, et al. (March 2003).
1221:
1008:
926:
902:
462:
220:
2782:"Clinical impact of selective serotonin reuptake inhibitors therapy with bleeding risks"
1958:
Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, et al. (August 2013).
1303:
718:
695:
11547:
11235:
8963:
8818:
8385:
8283:
7954:
7812:
7746:
7293:
7226:
5283:
4792:
4603:
4480:
4453:
4429:
4404:
4339:
4314:
4167:
4140:
4121:
4077:
4034:
3991:
3948:
3785:
3639:
3541:
3356:
3094:
2980:
2955:
2936:
2860:
2833:
2811:
2762:
2431:
2406:
2263:
2238:
1984:
1959:
1876:
1640:
1636:
984:
983:
Celecoxib was patented in 1993 and came into medical use in 1999. It is available as a
918:
187:
4380:
4363:
4313:
Bosetti C, Talamini R, Franceschi S, Negri E, Garavello W, La
Vecchia C (March 2003).
3169:
2378:
Flood J (March 2010). "The role of acetaminophen in the treatment of osteoarthritis".
2030:
2013:
1975:
1289:
10769:
10438:
10408:
8602:
8457:
8445:
8332:
7738:
7463:
7323:
7173:
6736:
6711:
6407:
5981:
4815:
4711:
4682:
4644:
4595:
4560:
4516:
4485:
4434:
4385:
4344:
4295:
4254:
4213:
4172:
4113:
4069:
4026:
3983:
3952:
3940:
3936:
3723:
3173:
3135:
3086:
3051:
3008:
2985:
2928:
2891:
2865:
2803:
2798:
2781:
2754:
2749:
2732:
2684:
2649:
2608:
2477:
2436:
2387:
2360:
2319:
2268:
2162:
2126:
2035:
1989:
1868:
1864:
1765:
1597:
647:
339:
319:
149:
4607:
4125:
4081:
4038:
3995:
3668:
3098:
2940:
2815:
2766:
2286:
Yelland MJ, Nikles CJ, McNairn N, Del Mar CB, Schluter PJ, Brown RM (January 2007).
1880:
1200:
P450 2C9. Caution must be exercised with concomitant use of 2C9 inhibitors, such as
11451:
11443:
11438:
10742:
10328:
9819:
9698:
9524:
9515:
9447:
9438:
9430:
9332:
9323:
9245:
9236:
9087:
9025:
8679:
8153:
7087:
6412:
6169:
5884:
5518:
5503:
5224:
4703:
4634:
4587:
4550:
4475:
4465:
4424:
4416:
4375:
4334:
4326:
4285:
4244:
4203:
4162:
4154:
4105:
4061:
4018:
3975:
3932:
3361:
3265:
3192:
3165:
3127:
3078:
3041:
2975:
2967:
2920:
2855:
2845:
2793:
2744:
2676:
2639:
2598:
2467:
2426:
2422:
2418:
2350:
2309:
2299:
2258:
2254:
2250:
2058:
2025:
2012:
Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA (March 2007).
1979:
1971:
1860:
1573:
1557:
1553:
1529:
1404:
1362:
1096:
731:
368:
262:
252:
57:
8926:
2304:
2287:
2182:
11506:
11299:
11231:
11141:
10816:
10794:
10764:
9461:
8863:
8782:
8764:
8577:
8342:
8327:
8268:
7651:
7552:
7467:
7205:
7195:
7153:
6619:
6537:
5851:
5813:
5604:
5026:
4941:
4707:
4537:
Zhu J, Song X, Lin HP, Young DC, Yan S, Marquez VE, et al. (December 2002).
2212:
1921:
1672:
1619:
1500:
1075:
cardiovascular risk profiles should be evaluated prior to prescribing. New-onset
1039:
who are older than two years of age and weigh more than 10 kg (22 lb).
874:
496:
400:
376:
232:
135:
7517:
7513:
6533:
6529:
4668:
4065:
4022:
3979:
10821:
10774:
10339:
9901:
8960:
8903:
8858:
8621:
8501:
8476:
8352:
8337:
7807:
7687:
7638:
7605:
7179:
6954:
6819:
6731:
6656:
6641:
6636:
6630:
6559:
6471:
6005:
5596:
5090:
4954:
4841:
4811:
4798:
4672:
3046:
3029:
2355:
2338:
1464:
1242:
1120:
1089:
1000:
957:
933:
890:
4591:
4555:
4538:
3753:
3475:
3387:
3082:
2971:
2924:
2405:
Puljak L, Marin A, Vrdoljak D, Markotic F, Utrobicic A, Tugwell P (May 2017).
1572:
A meta-analysis considering trials of celecoxib as an adjunctive treatment in
11516:
11418:
11102:
10887:
10784:
10662:
10647:
10580:
10510:
8792:
8787:
8777:
8707:
8669:
8127:
7902:
7832:
7692:
7661:
7610:
7313:
7190:
7003:
6988:
6869:
6804:
6345:
6305:
5675:
5548:
5429:
5372:
5130:
5079:
4639:
4622:
3893:
2572:
2529:
1629:
1561:
1263:
1181:
977:
707:
392:
352:
10958:
10875:
10801:
10779:
10732:
10667:
10637:
10617:
10612:
10535:
10423:
9848:
9810:
9678:
9505:
9341:
9226:
9033:
8797:
8772:
8530:
8435:
8319:
8106:
8094:
8084:
8059:
7927:
7917:
7847:
7722:
7717:
7628:
7185:
7148:
7133:
7077:
7062:
7057:
7008:
6983:
6973:
6968:
6726:
6604:
6584:
6579:
6569:
6551:
6392:
6356:
6240:
6230:
6184:
6180:
6142:
6050:
5840:
5779:
5775:
5756:
5751:
5730:
5719:
5533:
5527:
5513:
5508:
5439:
5434:
5387:
5273:
5140:
5120:
5049:
4998:
4988:
4802:
4794:
4715:
4686:
4648:
4599:
4564:
4520:
4489:
4470:
4438:
4420:
4389:
4348:
4330:
4299:
4258:
4217:
4176:
4117:
4073:
4030:
3987:
3944:
3177:
3090:
3055:
2989:
2932:
2869:
2807:
2758:
2688:
2680:
2653:
2612:
2481:
2440:
2391:
2364:
2323:
2272:
2039:
1993:
1872:
1644:
1255:
1080:
1076:
1020:
886:
257:
247:
7478:
3237:
3139:
2850:
2603:
2587:"Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis"
2586:
22:
11433:
11335:
11276:
11146:
11131:
11072:
11037:
11015:
10995:
10943:
10928:
10870:
10828:
10754:
10722:
10707:
10540:
10525:
10450:
10388:
10383:
10057:
9730:
9693:
9668:
9663:
9510:
9466:
9425:
9420:
9318:
9254:
9231:
9221:
9140:
9115:
9082:
9048:
8843:
8823:
8732:
8641:
8572:
8564:
8525:
8450:
8400:
8395:
8294:
8230:
8158:
8002:
7987:
7978:
7912:
7897:
7892:
7882:
7877:
7872:
7822:
7802:
7797:
7792:
7761:
7756:
7712:
7697:
7666:
7645:
7623:
7421:
indicates initially developed first-in-class compound of specific group;
7318:
7298:
7267:
7252:
7143:
7108:
7097:
6907:
6829:
6757:
6746:
6696:
6691:
6437:
6417:
6402:
6397:
6382:
6340:
6310:
6250:
6220:
6164:
6137:
6010:
5951:
5923:
5913:
5866:
5830:
5746:
5708:
5690:
5685:
5665:
5642:
5613:
5591:
5571:
5561:
5412:
5397:
5377:
5263:
5194:
5180:
5135:
5068:
5063:
5040:
5015:
4983:
4926:
4889:
4866:
4851:
4846:
4831:
4290:
4273:
4249:
4232:
4208:
4191:
2472:
2455:
1278:
1209:
1201:
1047:
961:
143:
39:
4505:"Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors"
3847:"Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan"
536:
11365:
11126:
11097:
11077:
11030:
11025:
11010:
10985:
10953:
10921:
10892:
10848:
10747:
10697:
10692:
10687:
10682:
10657:
10570:
10565:
10505:
10490:
10470:
10455:
10428:
10403:
10393:
10378:
10368:
10082:
10037:
10024:
9939:
9725:
9720:
9673:
9610:
9590:
9543:
9135:
8957:
8873:
8868:
8813:
8750:
8693:
8674:
8651:
8646:
8636:
8626:
8587:
8550:
8545:
8540:
8491:
8486:
8468:
8405:
8390:
8375:
8309:
8289:
8220:
8210:
8179:
8133:
8120:
8089:
8054:
7937:
7932:
7907:
7857:
7852:
7827:
7782:
7707:
7348:
7338:
7333:
7328:
7277:
7242:
7092:
7040:
7035:
7030:
7025:
6998:
6922:
6859:
6798:
6792:
6767:
6762:
6701:
6686:
6676:
6646:
6614:
6599:
6546:
6427:
6330:
6325:
6300:
6295:
6285:
6280:
6275:
6245:
6235:
6200:
6195:
6175:
6130:
6118:
6093:
6088:
6078:
6060:
6055:
6045:
6040:
5998:
5986:
5974:
5946:
5933:
5928:
5898:
5861:
5856:
5794:
5789:
5735:
5680:
5632:
5618:
5566:
5553:
5522:
5455:
5444:
5417:
5407:
5402:
5348:
5303:
5298:
5199:
5163:
5095:
5085:
5074:
5058:
5010:
4993:
4969:
4921:
4909:
4861:
4452:
Chuang HC, Kardosh A, Gaffney KJ, Petasis NA, Schönthal AH (May 2008).
4109:
2314:
1350:
1213:
1197:
1012:
894:
773:
547:
227:
4364:"Targeting cyclooxygenase-2 in human neoplasia: rationale and promise"
4158:
3131:
11390:
11330:
11062:
11020:
11005:
11000:
10990:
10980:
10975:
10965:
10880:
10863:
10858:
10853:
10737:
10717:
10712:
10677:
10672:
10632:
10605:
10560:
10555:
10550:
10530:
10485:
10480:
10443:
10433:
10358:
10077:
9984:
9833:
9770:
9683:
9600:
9405:
9390:
9211:
9206:
8878:
8838:
8833:
8687:
8535:
8496:
8440:
8370:
8304:
8299:
8258:
8243:
8215:
8194:
8189:
8184:
8143:
8099:
7887:
7862:
7727:
7656:
7584:
7509:
7343:
7308:
7272:
7262:
7257:
7247:
7237:
7232:
7215:
7168:
7082:
7067:
7052:
7020:
7014:
6978:
6944:
6933:
6927:
6889:
6854:
6849:
6844:
6824:
6787:
6782:
6716:
6671:
6624:
6589:
6574:
6442:
6422:
6377:
6367:
6361:
6265:
6159:
6083:
6073:
6028:
6015:
5956:
5918:
5846:
5784:
5725:
5714:
5670:
5627:
5586:
5580:
5576:
5538:
5465:
5460:
5450:
5422:
5382:
5343:
5318:
5308:
5268:
4914:
4904:
4899:
4894:
4856:
3003:
Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM (2008).
1484:
1425:
1420:
1376:
Two lawsuits arose over discovery of celecoxib. Daniel L. Simmons of
1358:
1354:
1180:
is a 'class effect' for increased CV risk for all NSAIDs". In a 2006
1162:
1043:
1031:, and to reduce the number of colon and rectal polyps in people with
973:
965:
482:
427:
129:
1766:"Celebrex 100mg capsule - Summary of Product Characteristics (SmPC)"
11223:
11218:
11047:
10909:
10904:
10843:
10833:
10811:
10806:
10727:
10702:
10652:
10595:
10585:
10520:
10515:
10475:
9790:
9410:
9216:
8848:
8727:
8722:
8582:
8481:
8253:
8248:
8225:
8174:
8148:
8138:
7947:
7942:
7922:
7837:
7817:
7766:
7579:
7564:
7158:
7138:
7124:
7072:
7046:
6993:
6917:
6912:
6884:
6874:
6814:
6809:
6777:
6609:
6594:
6564:
6351:
6315:
6255:
6023:
5961:
5741:
5637:
5609:
5288:
5125:
2239:"Single dose oral celecoxib for acute postoperative pain in adults"
1928:. American Society of Health-System Pharmacists. 11 November 2019.
1624:
1408:
1381:
1366:
1217:
1107:
counts; it does not inhibit platelet aggregation at approved doses.
1104:
969:
937:
596:
527:
171:
796:
663:
11360:
11171:
10938:
10465:
10418:
10363:
9909:
8853:
8828:
8698:
8683:
8430:
8360:
7992:
7964:
7787:
7702:
7547:
7358:
6959:
6772:
6721:
6665:
5244:
5145:
4959:
4820:
2571:
This article incorporates text from this source, which is in the
2528:
This article incorporates text from this source, which is in the
1536:
4054:
Progress in Neuro-Psychopharmacology & Biological Psychiatry
4011:
Progress in Neuro-Psychopharmacology & Biological Psychiatry
3968:
Progress in Neuro-Psychopharmacology & Biological Psychiatry
1088:
aspirin, anticoagulants and/or corticosteroids, smoking, use of
11121:
10322:
7633:
7535:
7526:
6899:
4884:
3604:"Celebrex Commercial, Long and Unconventional, Draws Criticism"
2161:(76 ed.). Pharmaceutical Press. 2018. pp. 1097–1098.
1622:
cells showed celecoxib could inhibit the growth of these cells
1585:
1480:
1385:
1349:
for arthritis. Celecoxib and other COX-2 selective inhibitors,
1346:
1062:
945:
627:
406:
4312:
4233:"A randomized trial of aspirin to prevent colorectal adenomas"
4192:"Celecoxib for the prevention of sporadic colorectal adenomas"
4094:
3669:"Top Pain Scientist Fabricated Data in Studies, Hospital Says"
10933:
7867:
7574:
7539:
4671:. In Pratt VM, McLeod HL, Rubinstein WS, et al. (eds.).
4189:
3116:
2890:(10th ed.). New York: McGraw-Hill Medical. p. 579.
2011:
1508:
1416:
1246:
1238:
787:
607:
3352:"Pfizer Settles B.Y.U. Lawsuit Over Development of Celebrex"
2453:
1639:
of celecoxib were generated with small alterations in their
680:
30:
4748:"FDA Approves Labeling Supplement for Celebrex (celecoxib)"
4451:
3921:
3781:"Judge cuts 18 months off patent life of Pfizer's Celebrex"
2625:
2584:
2404:
2285:
882:
587:
63:
4315:"Aspirin use and cancers of the upper aerodigestive tract"
4271:
4051:
3965:
3027:
2336:
1957:
78:
4502:
3537:"In Documents on Pain Drug, Signs of Doubt and Deception"
3489:"Drug Approval Package: Celebrex (Celecoxib) NDA# 20-998"
3433:
CAFC Court Decision Reach-Through Claims Declared Invalid
2093:
1710:
1281:(which may explain the reduction in cancer progression).
87:
69:
4577:
2546:"NSAIDs may cause rare kidney problems in unborn babies"
1341:
Discovery and development of cyclooxygenase 2 inhibitors
3635:"Doctor Admits Pain Studies Were Frauds, Hospital Says"
3289:"Judge orders Pfizer to pay BYU $ 852K for suit delays"
2831:
4361:
3002:
2540:
2538:
11490:
4230:
4139:
Rial NS, Zell JA, Cohen AM, Gerner EW (August 2012).
2780:
Turner MS, May DB, Arthur RR, Xiong GL (March 2007).
1667:
1665:
99:
84:
81:
75:
60:
2779:
2666:
1807:
1805:
1803:
1801:
1799:
1797:
1795:
1793:
1791:
1042:
For postoperative pain, it is more or less equal to
90:
66:
9064:
9007:
8956:
4614:
4138:
2535:
1695:
1579:
515:
72:
10345:
9487:
9372:
9295:
9188:
4146:Expert Review of Gastroenterology & Hepatology
3813:"FDA approves first generic versions of celecoxib"
3667:
2493:
2491:
1662:
1284:
9170:
8989:
4571:
3917:
3915:
3247:
2904:
2832:Mathew ST, Devi SG, Prasanth VV, Vinod B (2011).
2578:
2090:"FDA Panel Affirms Safety Of Painkiller Celebrex"
1788:
1056:
11514:
11266:
11247:
11202:
9644:
3320:"Pfizer, BYU settle Celebrex lawsuit for $ 450M"
1430:University of Rochester v. G.D. Searle & Co.
1394:University of Rochester v. G.D. Searle & Co.
819:c1cc(C)ccc1c2cc(C(F)(F)F)nn2c3ccc(cc3)S(=O)(=O)N
495:
4536:
4362:Dannenberg AJ, Subbaramaiah K (December 2003).
3007:(7th ed.). New York: McGraw-Hill Medical.
2701:
2488:
2118:
1490:The Journal of the American Medical Association
1237:A highly selective reversible inhibitor of the
470:
11308:
3912:
3570:"Celebrex Ads Are Back, Dire Warnings and All"
3452:. National Academy of Sciences. 15 June 2015.
3427:
3425:
3398:
3396:
3155:
1588:, so it is not a good choice for this reason.
1576:was inconclusive citing low evidence quality.
1475:
1065:, so it is not a good choice for this reason.
929:. Benefits are typically seen within an hour.
917:. It may also be used to decrease the risk of
11285:
9741:
8942:
7494:
6510:
4778:
4693:
4679:National Center for Biotechnology Information
3704:Mass. doctor accused of faking pain pill data
3286:
3034:Journal of the American College of Cardiology
2737:Journal of Clinical Pharmacy and Therapeutics
1258:(and pain) while minimizing gastrointestinal
9869:
3823:(Press release). 31 May 2014. Archived from
3280:
3256:"University sues Pfizer over COX-2 research"
3158:Bioorganic & Medicinal Chemistry Letters
2730:
2724:
2660:
2619:
2046:
1266:) that are common with nonselective NSAIDs.
999:Celecoxib is indicated for the treatment of
175:
7508:
4183:
4008:
3422:
3393:
3005:Pharmacotherapy A Pathophysiologic Approach
2996:
2411:The Cochrane Database of Systematic Reviews
2243:The Cochrane Database of Systematic Reviews
1953:
1951:
1949:
1947:
1916:
1914:
1912:
1910:
1673:"Celecoxib (Celebrex) Use During Pregnancy"
1596:The use of celecoxib to reduce the risk of
360:In general: ℞ (Prescription only)
8949:
8935:
7501:
7487:
6517:
6503:
4785:
4771:
4355:
3659:
3567:
3530:
3528:
3526:
3524:
3522:
3520:
3518:
3311:
3184:
3112:
3110:
3108:
2881:
2879:
2236:
2083:
2081:
1908:
1906:
1904:
1902:
1900:
1898:
1896:
1894:
1892:
1890:
1196:Celecoxib is predominantly metabolized by
1152:
717:
694:
555:
4638:
4620:
4554:
4479:
4469:
4428:
4402:
4379:
4338:
4289:
4248:
4207:
4166:
3223:"Dr. John Talley: 2001 St. Louis Awardee"
3068:
3045:
2979:
2913:European Journal of Clinical Pharmacology
2859:
2849:
2827:
2825:
2797:
2748:
2643:
2602:
2471:
2430:
2354:
2330:
2313:
2303:
2262:
2029:
2007:
2005:
2003:
1983:
1850:
575:
16:Nonsteroidal anti-inflammatory medication
4543:Journal of the National Cancer Institute
3665:
3561:
3253:
3190:
3151:
3149:
2953:
2910:
2702:Jenkins JK, Seligman PJ (6 April 2005).
2159:British national formulary : BNF 76
1944:
4669:"Celecoxib Therapy and CYP2C9 Genotype"
4580:Expert Opinion on Investigational Drugs
4306:
4265:
3778:
3626:
3597:
3595:
3515:
3444:
3442:
3440:
3404:"Reach-Through Claims Declared Invalid"
3105:
2885:
2876:
2695:
2645:10.7326/0003-4819-142-3-200502010-00005
2279:
2112:
2078:
1922:"Celecoxib Monograph for Professionals"
1887:
1846:
1844:
1842:
1840:
1838:
1539:after Upjohn was spun off from Pfizer.
1212:-converting enzyme-inhibitors, such as
1206:selective serotonin reuptake inhibitors
690:
535:
148:
11515:
10340:
4532:
4530:
4445:
3632:
3601:
3534:
3317:
2822:
2731:Chen LC, Ashcroft DM (December 2006).
2125:. John Wiley & Sons. p. 522.
2000:
1730:
1470:
1227:
708:
333:
8930:
7482:
6526:Non-steroidal anti-inflammatory drugs
6498:
4766:
4224:
3410:from the original on 22 February 2014
3368:from the original on 27 December 2017
3215:
3146:
2377:
2151:
2087:
2066:from the original on 18 December 2015
1823:from the original on 24 February 2021
1432:, 358 F.3d 916 (Fed. Cir. 2004), the
656:
635:
615:
346:
166:
134:
11538:Nonsteroidal anti-inflammatory drugs
10963:Selective COX-2 inhibitors (coxibs):
7453:
4666:
3614:from the original on 17 January 2018
3592:
3437:
3299:from the original on 31 October 2009
2556:from the original on 17 October 2020
2513:from the original on 16 October 2020
2380:The American Journal of Managed Care
2193:from the original on 15 January 2024
1835:
1683:from the original on 25 January 2021
1591:
1232:
1191:
1046:. For pain relief, it is similar to
662:
261:
251:
9072:Tooltip Prostaglandin D2 receptor 2
9015:Tooltip Prostaglandin D2 receptor 1
7104:COX-inhibiting nitric oxide donator
5054:ribonucleotide reductase inhibitors
4527:
4278:The New England Journal of Medicine
4237:The New England Journal of Medicine
4196:The New England Journal of Medicine
3760:from the original on 9 January 2017
3682:from the original on 30 August 2017
3580:from the original on 7 January 2016
3549:from the original on 3 January 2016
3456:from the original on 7 January 2016
2591:The New England Journal of Medicine
2460:The New England Journal of Medicine
2213:"Celecoxib - Drug Usage Statistics"
1608:
1567:
1535:In the US, Celebrex is marketed by
1361:, were discovered by a team at the
1184:of randomized control studies, the
940:. Serious side effects may include
879:nonsteroidal anti-inflammatory drug
595:
486:
325:
13:
10934:AM-404 (N-arachidonoylaminophenol)
10752:Anthranilic acids (fenamic acids):
10404:Mesalazine (5-aminosalicylic acid)
9495:Tooltip Prostaglandin EP4 receptor
9380:Tooltip Prostaglandin EP3 receptor
9303:Tooltip Prostaglandin EP2 receptor
9196:Tooltip Prostaglandin EP1 receptor
5220:Ribonucleotide reductase inhibitor
5176:Ribonucleotide reductase inhibitor
4659:
3734:from the original on 10 March 2016
3503:from the original on 27 March 2019
3203:from the original on 16 April 2018
2509:(Press release). 15 October 2020.
2237:Derry S, Moore RA (October 2013).
2139:from the original on 27 April 2021
1776:from the original on 6 August 2020
1746:from the original on 3 August 2023
1309:
1302:
1295:
1288:
1173:In 2005, a study published in the
1068:
1035:. It may be used in children with
233:Cyclooxygenase-2 (COX-2) inhibitor
14:
11574:
11424:γ-Linolenic acid (gamolenic acid)
10770:Meclofenamic acid (meclofenamate)
9179:Tooltip Prostaglandin E2 receptor
8998:Tooltip Prostaglandin D2 receptor
8593:Tetrahydrocannabinol (dronabinol)
4979:Dihydrofolate reductase inhibitor
4724:
3793:from the original on 25 July 2017
3702:"Associated Press, Mar 11, 2009,
3332:from the original on 3 March 2016
3287:Linda Thomson (28 October 2009).
3071:Expert Opinion on Pharmacotherapy
2888:Basic & clinical pharmacology
2550:U.S. Food and Drug Administration
2054:"Should you still take Celebrex?"
2031:10.1161/circulationaha.106.181424
881:(NSAID). It is used to treat the
288:
198:
120:Celebrex, Onsenal, Elyxyb, others
11500:
11479:Leukotriene signaling modulators
11271:Tooltip Prostaglandin F synthase
11252:Tooltip Prostaglandin E synthase
11211:Tooltip Prostaglandin D synthase
9653:Tooltip Prostaglandin F receptor
7462:
7452:
7443:
7442:
3937:10.1016/j.jpsychires.2021.09.018
3647:from the original on 17 May 2017
3236:(5): 2. May 2001. Archived from
2799:10.1111/j.1365-2796.2006.01720.x
2750:10.1111/j.1365-2710.2006.00774.x
2566:
2523:
2100:from the original on 20 May 2018
1932:from the original on 20 May 2019
1865:10.2165/11208240-000000000-00000
1503:, former chief of acute pain at
754:
748:
742:
56:
38:
29:
10790:Talinflumic acid (talinflumate)
10780:Morniflumic acid (morniflumate)
10760:Floctafenic acid (floctafenate)
10743:Tiaprofenic acid (tiaprofenate)
7354:Superoxide dismutase / orgotein
4496:
4396:
4132:
4088:
4045:
4002:
3959:
3925:Journal of Psychiatric Research
3886:
3861:
3839:
3805:
3772:
3746:
3716:
3694:
3481:
3468:
3380:
3344:
3062:
3021:
2947:
2773:
2447:
2398:
2371:
2230:
2205:
2175:
2119:Fischer J, Ganellin CR (2006).
1285:Structure-activity relationship
994:
844:Key:RZEKVGVHFLEQIL-UHFFFAOYSA-N
11313:Tooltip Thromboxane A synthase
10364:Aspirin (acetylsalicylic acid)
9578:16,16-Dimethyl Prostaglandin E
8361:Aspirin (acetylsalicylic acid)
6666:Aspirin (acetylsalicylic acid)
5116:Thymidylate synthase inhibitor
5006:Thymidylate synthase inhibitor
4403:Schönthal AH (December 2007).
4098:Acta Psychiatrica Scandinavica
3120:Journal of Medicinal Chemistry
2423:10.1002/14651858.CD009865.pub2
2407:"Celecoxib for osteoarthritis"
2255:10.1002/14651858.CD004233.pub4
1758:
1724:
1580:Familial adenomatous polyposis
1519:
1443:direct-to-consumer advertising
1415:in 1993 oversaw research into
1269:
1057:Familial adenomatous polyposis
1033:familial adenomatous polyposis
923:familial adenomatous polyposis
766:
760:
736:
314:
301:
1:
11472:Receptor/signaling modulators
11294:Tooltip Prostacyclin synthase
10795:Tolfenamic acid (tolfenamate)
10765:Flufenamic acid (flufenamate)
10755:Etofenamic acid (etofenamate)
9811:Prostacyclin (prostaglandin I
9750:Tooltip Prostacyclin receptor
5036:Adenosine deaminase inhibitor
4877:Block microtubule disassembly
4381:10.1016/S1535-6108(03)00310-6
3754:"US Re-issued Patent RE44048"
3666:Winstein KJ (11 March 2009).
3170:10.1016/s0960-894x(00)00522-9
2122:Analogue-based Drug Discovery
1976:10.1016/S0140-6736(13)60900-9
1813:"Celebrex- celecoxib capsule"
1655:
1547:
1345:It was initially marketed by
1037:juvenile rheumatoid arthritis
1029:juvenile rheumatoid arthritis
915:juvenile rheumatoid arthritis
310:(Other controlled substances)
9878:Tooltip Thromboxane receptor
4754:Food and Drug Administration
4738:Food and Drug Administration
4708:10.1001/jama.296.13.jrv60015
3819:Food and Drug Administration
3568:Berenson A (29 April 2006).
3495:Food and Drug Administration
3254:Yajnik J (27 October 2006).
2786:Journal of Internal Medicine
2711:Food and Drug Administration
2505:Food and Drug Administration
2343:Osteoarthritis and Cartilage
1513:Food and Drug Administration
1494:Food and Drug Administration
1407:, who was vice president of
1401:National Academy of Sciences
1117:Food and Drug Administration
950:gastrointestinal perforation
932:Common side effects include
869:, sold under the brand name
7:
10944:Paracetamol (acetaminophen)
10775:Mefenamic acid (mefenamate)
10429:Salicylate (salicylic acid)
8003:Paracetamol (acetaminophen)
6732:Salicylic acid (salicylate)
4621:Schönthal AH (April 2006).
4066:10.1016/j.pnpbp.2014.01.013
4023:10.1016/j.pnpbp.2013.09.006
3980:10.1016/j.pnpbp.2012.11.008
3779:Parloff R (13 March 2014).
3191:Langreth R (23 June 2003).
2632:Annals of Internal Medicine
2305:10.1093/rheumatology/kel195
1542:
1476:Fabricated efficacy studies
1176:Annals of Internal Medicine
1101:partial thromboplastin time
972:. Use in the later part of
10:
11579:
10623:Bucloxic acid (blucloxate)
10541:Indometacin (indomethacin)
4689:. Bookshelf ID: NBK379478.
4674:Medical Genetics Summaries
3857:– via Business Wire.
3849:. Pfizer. 16 November 2020
3633:Harris G (11 March 2009).
3047:10.1016/j.jacc.2008.08.002
2960:Rheumatology International
2356:10.1016/j.joca.2007.06.014
1742:(published 4 April 2023).
1338:
1334:
1167:American Heart Association
1147:toxic epidermal necrolysis
1127:
1115:In October 2020, the U.S.
726:Chemical and physical data
11558:Trifluoromethyl compounds
11543:Drugs developed by Pfizer
11463:
11408:
11306:
11283:
11264:
11245:
11200:
10785:Niflumic acid (niflumate)
10338:
10321:
10096:
9889:Carbocyclic thromboxane A
9867:
9739:
9642:
9567:
9485:
9370:
9293:
9186:
9168:
9062:
9005:
8987:
8970:
8887:
8806:
8763:
8741:
8704:Tricyclic antidepressants
8660:
8612:
8601:
8563:
8518:
8467:
8351:
8318:
8267:
8203:
8167:
8077:
8068:
7977:
7775:
7593:
7534:
7525:
7438:
7415:
7367:
7286:
7204:
7117:
6953:
6898:
6745:
6655:
6545:
6455:
6336:Omacetaxine mepesuccinate
6216:Ciltacabtagene autoleucel
6206:Brexucabtagene autoleucel
6152:
6103:
5883:
5876:
5812:
5766:
5699:
5656:
5493:
5478:
5358:
5328:
5253:
5238:
5209:
5105:
5025:
4968:
4951:
4940:
4876:
4829:
4810:
4592:10.1517/13543784.17.2.197
4409:British Journal of Cancer
4319:British Journal of Cancer
3535:Thomas K (24 June 2012).
3083:10.1517/14656560802560153
2972:10.1007/s00296-011-2263-6
2954:Conaghan PG (June 2012).
2925:10.1007/s00228-007-0400-7
2088:Stein R (25 April 2018).
1411:in 1989 and president of
954:gastrointestinal bleeding
852:
827:
807:
785:
772:
730:
725:
706:
674:
646:
626:
606:
586:
566:
546:
526:
506:
481:
461:
441:
436:
432:Faeces (57%), urine (27%)
426:
413:
399:
385:
375:
367:
278:
273:
238:
226:
212:
186:
156:
142:
124:
114:
51:
46:
37:
28:
11103:Menatetrenone (vitamin K
10926:Aminophenols (anilines):
8038:+propyphenazone/caffeine
7402:Naproxen/diphenhydramine
6388:Talimogene laherparepvec
6321:Nadofaragene firadenovec
6291:Lisocabtagene maraleucel
5240:Topoisomerase inhibitors
5159:DNA polymerase inhibitor
4640:10.3171/foc.2006.20.4.14
3602:Saul S (10 April 2007).
1378:Brigham Young University
1143:Stevens-Johnson syndrome
329:: Prescription only
11429:Dihomo-γ-linolenic acid
10826:Enolic acids (oxicams):
10369:Benorilate (benorylate)
7423:WHO-Essential Medicines
6191:Axicabtagene ciloleucel
4795:chemotherapeutic agents
4556:10.1093/jnci/94.23.1745
3675:The Wall Street Journal
3318:Harvey T (1 May 2012).
1740:Diário Oficial da União
1505:Baystate Medical Center
1434:University of Rochester
1390:University of Rochester
1153:Heart attack and stroke
991:million prescriptions.
11228:selenium tetrachloride
7888:Pethidine (meperidine)
6751:and related substances
6373:Sitimagene ceradenovec
6271:Idecabtagene vicleucel
5836:Methyl aminolevulinate
4471:10.1186/1476-4598-7-38
4421:10.1038/sj.bjc.6604049
4331:10.1038/sj.bjc.6600820
3193:"The Chemical Cobbler"
2681:10.1001/jama.286.8.954
1650:2,5-dimethyl-celecoxib
1314:
1307:
1300:
1293:
1260:adverse drug reactions
1252:sulfonamide side chain
1186:cerebrovascular events
1139:exfoliative dermatitis
1025:ankylosing spondylitis
907:ankylosing spondylitis
10897:Aminonicotinic acids:
8509:+paracetamol/caffeine
8487:Metamizole (dipyrone)
8421:Morpholine salicylate
8365:+paracetamol/caffeine
7407:Naproxen/esomeprazole
7397:Meloxicam/bupivacaine
7392:Ibuprofen/paracetamol
7382:Ibuprofen/hydrocodone
5847:Porphyrin derivatives
5543:Melphalan flufenamide
5190:Hypomethylating agent
4799:antineoplastic agents
3476:U.S. patent 5,466,823
3431:Ranjana Kadle (2004)
3388:U.S. patent 6,048,850
3325:The Salt Lake Tribune
2713:(FDA). Archived from
2604:10.1056/NEJMoa1611593
2183:"The Top 300 of 2021"
1313:
1306:
1299:
1292:
1132:Celecoxib contains a
11523:Antineoplastic drugs
10546:Indometacin farnesil
10399:Magnesium salicylate
10030:Pinane thromboxane A
9791:Iloprost (ciloprost)
9411:Iloprost (ciloprost)
9217:Iloprost (ciloprost)
8632:Gabapentin enacarbil
8426:Potassium salicylate
8416:Magnesium salicylate
8411:Imidazole salicylate
8238:Indometacin farnesil
7634:Diamorphine (heroin)
7601:Acetyldihydrocodeine
7377:Ibuprofen/famotidine
6835:Indometacin farnesil
6707:Magnesium salicylate
6528:(NSAIDs) (primarily
6176:Asparagine depleters
6105:Receptor antagonists
6019:+abiraterone acetate
4291:10.1056/NEJMoa021633
4250:10.1056/NEJMoa021735
4209:10.1056/NEJMoa061355
3499:. 24 December 1999.
2720:on 9 September 2005.
2473:10.1056/NEJMoa050405
1161:The COX-2 inhibitor
1017:musculoskeletal pain
1005:rheumatoid arthritis
980:is not recommended.
911:painful menstruation
899:rheumatoid arthritis
453:4-benzenesulfonamide
10374:Carbasalate calcium
8381:Carbasalate calcium
7387:Ibuprofen/oxycodone
7304:Chondroitin sulfate
6682:Carbasalate calcium
6226:Denileukin diftitox
6126:Retinoid X receptor
5826:Aminolevulinic acid
5648:Triethylenemelamine
5480:Crosslinking of DNA
5211:Deoxyribonucleotide
5150:+gimeracil/oteracil
4627:Neurosurgical Focus
2886:Katzung BG (2007).
2851:10.5402/2011/480291
1772:. 13 January 2020.
1641:chemical structures
1471:Society and culture
1327:structures 6 – 9).
1277:Celecoxib binds to
1228:Mechanism of action
1222:hydrochlorothiazide
1119:(FDA) required the
1079:or exacerbation of
1009:psoriatic arthritis
919:colorectal adenomas
903:psoriatic arthritis
873:among others, is a
342:(Prescription only)
297:(Prescription only)
25:
11236:selenium disulfide
10868:4-Aminoquinolines:
8914:Never to phase III
8819:Analgesic adjuvant
8720:1.7/1.8-selective:
8386:Choline salicylate
7813:Dextropropoxyphene
7294:Aminopropionitrile
6482:Never to phase III
5284:Etirinotecan pegol
4110:10.1111/acps.12211
3900:. 16 November 2020
3640:The New York Times
3608:The New York Times
3574:The New York Times
3542:The New York Times
3450:"Philip Needleman"
3357:The New York Times
3268:on 3 February 2009
1492:. In 2001, the US
1315:
1308:
1301:
1294:
985:generic medication
21:
11563:4-Tolyl compounds
11533:CYP2D6 inhibitors
11488:
11487:
11404:
11403:
10439:Sodium salicylate
10409:Methyl salicylate
10332:
10317:
10316:
9638:
9637:
9164:
9163:
8981:
8924:
8923:
8759:
8758:
8743:Potassium openers
8680:Local anesthetics
8622:Alcohol (ethanol)
8559:
8558:
8458:methyl salicylate
8446:Sodium salicylate
8333:Meclofenamic acid
8008:+aspirin/caffeine
7973:
7972:
7476:
7475:
7324:Glycosaminoglycan
7174:Meclofenamic acid
6737:Sodium salicylate
6712:Methyl salicylate
6492:
6491:
6451:
6450:
6408:Tigilanol tiglate
5885:Enzyme inhibitors
5808:
5807:
5804:
5803:
5504:Nitrogen mustards
5474:
5473:
5234:
5233:
4936:
4935:
4159:10.1586/egh.12.23
3712:on 16 March 2009.
3243:on 15 April 2018.
3132:10.1021/jm960803q
3014:978-0-07-147899-1
2838:ISRN Pharmacology
2386:(Suppl): S48–54.
1734:(31 March 2023).
1598:colorectal cancer
1592:Cancer prevention
1483:and its partner,
1399:According to the
1233:Anti-inflammatory
1192:Drug interactions
864:
863:
798:Interactive image
676:CompTox Dashboard
350:
337:
328:
317:
305:
292:
202:
169:
11570:
11528:COX-2 inhibitors
11505:
11504:
11503:
11496:
11439:Arachidonic acid
11314:
11310:
11295:
11291:
11272:
11268:
11253:
11249:
11212:
11208:
11035:Others/unsorted:
10610:Propionic acids:
10591:Sulindac sulfide
10356:Salicylic acids:
10347:
10342:
10336:
10335:
10326:
9879:
9875:
9751:
9747:
9654:
9650:
9496:
9492:
9381:
9377:
9304:
9300:
9197:
9193:
9184:
9183:
9180:
9176:
9073:
9069:
9016:
9012:
9003:
9002:
8999:
8995:
8985:
8984:
8975:
8951:
8944:
8937:
8928:
8927:
8614:Calcium blockers
8610:
8609:
8506:
8455:
8281:
8269:COX-2 inhibitors
8235:
8154:Tiaprofenic acid
8125:
8112:
8104:
8075:
8074:
7952:
7732:
7671:
7643:
7615:
7532:
7531:
7503:
7496:
7489:
7480:
7479:
7466:
7456:
7455:
7446:
7445:
7206:COX-2 inhibitors
7121:-arylanthranilic
7088:Tiaprofenic acid
6519:
6512:
6505:
6496:
6495:
6413:Tisagenlecleucel
6170:Arsenic trioxide
5881:
5880:
5814:Photosensitizers
5605:Alkyl sulfonates
5519:Cyclophosphamide
5491:
5490:
5430:Anthracenediones
5251:
5250:
5225:Hydroxycarbamide
4966:
4965:
4949:
4948:
4827:
4826:
4787:
4780:
4773:
4764:
4763:
4759:
4743:
4719:
4690:
4653:
4652:
4642:
4618:
4612:
4611:
4575:
4569:
4568:
4558:
4534:
4525:
4524:
4515:(5): 1306–1311.
4500:
4494:
4493:
4483:
4473:
4458:Molecular Cancer
4449:
4443:
4442:
4432:
4400:
4394:
4393:
4383:
4359:
4353:
4352:
4342:
4310:
4304:
4303:
4293:
4269:
4263:
4262:
4252:
4228:
4222:
4221:
4211:
4187:
4181:
4180:
4170:
4136:
4130:
4129:
4092:
4086:
4085:
4049:
4043:
4042:
4006:
4000:
3999:
3963:
3957:
3956:
3919:
3910:
3909:
3907:
3905:
3890:
3884:
3883:
3881:
3879:
3865:
3859:
3858:
3856:
3854:
3843:
3837:
3836:
3834:
3832:
3809:
3803:
3802:
3800:
3798:
3776:
3770:
3769:
3767:
3765:
3750:
3744:
3743:
3741:
3739:
3720:
3714:
3713:
3708:. Archived from
3698:
3692:
3691:
3689:
3687:
3671:
3663:
3657:
3656:
3654:
3652:
3630:
3624:
3623:
3621:
3619:
3599:
3590:
3589:
3587:
3585:
3565:
3559:
3558:
3556:
3554:
3532:
3513:
3512:
3510:
3508:
3485:
3479:
3478:
3472:
3466:
3465:
3463:
3461:
3446:
3435:
3429:
3420:
3419:
3417:
3415:
3400:
3391:
3390:
3384:
3378:
3377:
3375:
3373:
3362:Associated Press
3348:
3342:
3341:
3339:
3337:
3315:
3309:
3308:
3306:
3304:
3284:
3278:
3277:
3275:
3273:
3264:. Archived from
3251:
3245:
3244:
3242:
3227:
3219:
3213:
3212:
3210:
3208:
3188:
3182:
3181:
3153:
3144:
3143:
3114:
3103:
3102:
3066:
3060:
3059:
3049:
3025:
3019:
3018:
3000:
2994:
2993:
2983:
2951:
2945:
2944:
2908:
2902:
2901:
2883:
2874:
2873:
2863:
2853:
2829:
2820:
2819:
2801:
2777:
2771:
2770:
2752:
2728:
2722:
2721:
2719:
2708:
2699:
2693:
2692:
2664:
2658:
2657:
2647:
2623:
2617:
2616:
2606:
2582:
2576:
2570:
2569:
2565:
2563:
2561:
2552:. 21 July 2017.
2542:
2533:
2527:
2526:
2522:
2520:
2518:
2495:
2486:
2485:
2475:
2451:
2445:
2444:
2434:
2402:
2396:
2395:
2375:
2369:
2368:
2358:
2334:
2328:
2327:
2317:
2307:
2283:
2277:
2276:
2266:
2249:(10): CD004233.
2234:
2228:
2227:
2225:
2223:
2209:
2203:
2202:
2200:
2198:
2179:
2173:
2172:
2155:
2149:
2148:
2146:
2144:
2116:
2110:
2109:
2107:
2105:
2085:
2076:
2075:
2073:
2071:
2059:Consumer Reports
2050:
2044:
2043:
2033:
2009:
1998:
1997:
1987:
1970:(9894): 769–79.
1955:
1942:
1941:
1939:
1937:
1918:
1885:
1884:
1848:
1833:
1832:
1830:
1828:
1809:
1786:
1785:
1783:
1781:
1762:
1756:
1755:
1753:
1751:
1728:
1722:
1721:
1719:
1717:
1707:nctr-crs.fda.gov
1699:
1693:
1692:
1690:
1688:
1669:
1609:Cancer treatment
1574:bipolar disorder
1568:Bipolar disorder
1558:bipolar disorder
1554:major depression
1530:double patenting
1462:
1461:
1457:
1454:
1405:Philip Needleman
1097:prothrombin time
990:
860:
859:
800:
780:
768:
762:
756:
750:
744:
738:
721:
710:
699:
698:
684:
682:
666:
660:
639:
619:
599:
579:
559:
539:
519:
499:
489:
488:
474:
418:
355:
348:
345:
335:
332:
327:
324:
316:
313:
303:
300:
290:
287:
265:
255:
200:
197:
179:
168:
165:
152:
138:
106:
102:
97:
96:
93:
92:
89:
86:
83:
80:
77:
74:
71:
68:
65:
62:
42:
33:
26:
24:
20:
11578:
11577:
11573:
11572:
11571:
11569:
11568:
11567:
11513:
11512:
11511:
11501:
11499:
11491:
11489:
11484:
11459:
11455:
11452:Prostaglandin H
11447:
11444:Prostaglandin G
11400:
11312:
11302:
11300:Tranylcypromine
11293:
11289:
11279:
11270:
11260:
11251:
11241:
11232:sodium selenite
11210:
11206:
11196:
11142:Rosmarinic acid
11106:
10914:Sulfonanilides:
10817:Oxyphenbutazone
10343:
10325:
10313:
10092:
10033:
9905:
9892:
9877:
9873:
9863:
9823:
9820:Prostaglandin E
9815:, epoprostenol)
9814:
9749:
9745:
9735:
9710:
9707:Prostaglandin F
9702:
9699:Prostaglandin D
9652:
9648:
9634:
9619:
9616:Prostaglandin F
9581:
9563:
9528:
9525:Prostaglandin E
9519:
9516:Prostaglandin E
9494:
9491:
9481:
9462:Ricinoleic acid
9451:
9448:Prostaglandin E
9442:
9439:Prostaglandin E
9434:
9431:Prostaglandin D
9379:
9376:
9366:
9336:
9333:Prostaglandin E
9327:
9324:Prostaglandin E
9302:
9299:
9289:
9249:
9246:Prostaglandin E
9240:
9237:Prostaglandin E
9195:
9192:
9178:
9174:
9160:
9091:
9088:Prostaglandin D
9071:
9068:
9058:
9029:
9026:Prostaglandin D
9014:
9011:
8997:
8993:
8974:
8966:
8955:
8925:
8920:
8919:
8904:Clinical trials
8883:
8864:Phenazopyridine
8802:
8783:Cyclobenzaprine
8755:
8737:
8719:
8662:Sodium blockers
8656:
8604:
8597:
8555:
8514:
8504:
8463:
8453:
8347:
8343:Tolfenamic acid
8328:Flufenamic acid
8314:
8279:
8263:
8233:
8199:
8163:
8123:
8110:
8102:
8064:
8028:+metoclopramide
7969:
7950:
7771:
7730:
7669:
7652:Dihydromorphine
7641:
7613:
7589:
7521:
7507:
7477:
7472:
7434:
7427:withdrawn drugs
7411:
7369:
7363:
7282:
7208:
7200:
7196:Tolfenamic acid
7154:Flufenamic acid
7122:
7113:
6957:
6949:
6894:
6750:
6741:
6651:
6620:Oxyphenbutazone
6550:
6541:
6523:
6493:
6488:
6487:
6472:Clinical trials
6447:
6153:Other/ungrouped
6148:
6099:
5872:
5852:Porfimer sodium
5800:
5762:
5695:
5652:
5482:
5470:
5354:
5324:
5242:
5230:
5205:
5101:
5021:
4957:
4955:antimetabolites
4953:
4952:DNA precursors/
4944:
4942:DNA replication
4932:
4872:
4842:Vinca alkaloids
4818:
4806:
4791:
4758:. 28 June 2018.
4746:
4742:. 15 July 2005.
4730:
4727:
4722:
4702:(13): 1619–32.
4667:Dean L (2016).
4662:
4660:Further reading
4657:
4656:
4619:
4615:
4576:
4572:
4549:(23): 1745–57.
4535:
4528:
4509:Cancer Research
4501:
4497:
4450:
4446:
4401:
4397:
4360:
4356:
4311:
4307:
4270:
4266:
4229:
4225:
4188:
4184:
4137:
4133:
4093:
4089:
4050:
4046:
4007:
4003:
3964:
3960:
3920:
3913:
3903:
3901:
3892:
3891:
3887:
3877:
3875:
3867:
3866:
3862:
3852:
3850:
3845:
3844:
3840:
3830:
3828:
3811:
3810:
3806:
3796:
3794:
3777:
3773:
3763:
3761:
3752:
3751:
3747:
3737:
3735:
3722:
3721:
3717:
3700:
3699:
3695:
3685:
3683:
3664:
3660:
3650:
3648:
3631:
3627:
3617:
3615:
3600:
3593:
3583:
3581:
3566:
3562:
3552:
3550:
3533:
3516:
3506:
3504:
3487:
3486:
3482:
3474:
3473:
3469:
3459:
3457:
3448:
3447:
3438:
3430:
3423:
3413:
3411:
3402:
3401:
3394:
3386:
3385:
3381:
3371:
3369:
3350:
3349:
3345:
3335:
3333:
3316:
3312:
3302:
3300:
3285:
3281:
3271:
3269:
3252:
3248:
3240:
3225:
3221:
3220:
3216:
3206:
3204:
3189:
3185:
3154:
3147:
3115:
3106:
3067:
3063:
3040:(18): 1502–17.
3026:
3022:
3015:
3001:
2997:
2966:(6): 1491–502.
2952:
2948:
2909:
2905:
2898:
2884:
2877:
2830:
2823:
2778:
2774:
2729:
2725:
2717:
2706:
2700:
2696:
2665:
2661:
2624:
2620:
2597:(26): 2519–29.
2583:
2579:
2567:
2559:
2557:
2544:
2543:
2536:
2524:
2516:
2514:
2497:
2496:
2489:
2466:(11): 1071–80.
2452:
2448:
2417:(7): CD009865.
2403:
2399:
2376:
2372:
2349:(9): 981–1000.
2335:
2331:
2284:
2280:
2235:
2231:
2221:
2219:
2211:
2210:
2206:
2196:
2194:
2181:
2180:
2176:
2169:
2157:
2156:
2152:
2142:
2140:
2133:
2117:
2113:
2103:
2101:
2086:
2079:
2069:
2067:
2062:. August 2009.
2052:
2051:
2047:
2024:(12): 1634–42.
2010:
2001:
1956:
1945:
1935:
1933:
1920:
1919:
1888:
1859:(18): 2457–89.
1849:
1836:
1826:
1824:
1819:. 31 May 2019.
1811:
1810:
1789:
1779:
1777:
1764:
1763:
1759:
1749:
1747:
1729:
1725:
1715:
1713:
1701:
1700:
1696:
1686:
1684:
1671:
1670:
1663:
1658:
1620:malignant tumor
1611:
1594:
1582:
1570:
1550:
1545:
1522:
1501:Scott S. Reuben
1499:In March 2009,
1478:
1473:
1459:
1455:
1452:
1450:
1343:
1337:
1325:
1321:
1287:
1272:
1235:
1230:
1194:
1155:
1130:
1071:
1069:Adverse effects
1059:
997:
988:
921:in people with
875:COX-2 inhibitor
855:
853:
848:
845:
840:
835:
834:
823:
820:
815:
814:
803:
778:
765:
759:
753:
747:
741:
702:
678:
670:
642:
622:
602:
582:
562:
542:
522:
502:
485:
477:
457:
454:
449:
448:
416:
391:97% (mainly to
387:Protein binding
377:Bioavailability
369:Pharmacokinetic
363:
353:
269:
215:
208:
189:
182:
104:
100:
59:
55:
17:
12:
11:
5:
11576:
11566:
11565:
11560:
11555:
11550:
11545:
11540:
11535:
11530:
11525:
11510:
11509:
11486:
11485:
11483:
11482:
11475:
11468:
11464:
11461:
11460:
11458:
11457:
11453:
11449:
11445:
11441:
11436:
11434:Diacylglycerol
11431:
11426:
11421:
11412:
11410:
11406:
11405:
11402:
11401:
11399:
11398:
11393:
11388:
11383:
11378:
11373:
11368:
11363:
11358:
11353:
11348:
11343:
11338:
11333:
11328:
11323:
11317:
11315:
11304:
11303:
11298:
11296:
11287:
11281:
11280:
11275:
11273:
11262:
11261:
11256:
11254:
11243:
11242:
11240:
11239:
11221:
11215:
11213:
11204:
11198:
11197:
11195:
11194:
11189:
11184:
11179:
11174:
11169:
11164:
11159:
11154:
11149:
11144:
11139:
11134:
11129:
11124:
11119:
11114:
11109:
11104:
11100:
11095:
11090:
11085:
11080:
11075:
11070:
11065:
11060:
11055:
11050:
11045:
11040:
11028:
11023:
11018:
11013:
11008:
11003:
10998:
10993:
10988:
10983:
10978:
10973:
10968:
10956:
10951:
10946:
10941:
10936:
10931:
10919:
10907:
10902:
10890:
10878:
10873:
10861:
10856:
10851:
10846:
10841:
10836:
10831:
10822:Phenylbutazone
10819:
10814:
10809:
10804:
10792:
10787:
10782:
10777:
10772:
10767:
10762:
10757:
10745:
10740:
10735:
10730:
10725:
10720:
10715:
10710:
10705:
10700:
10695:
10690:
10685:
10680:
10675:
10670:
10665:
10660:
10655:
10650:
10645:
10640:
10635:
10630:
10625:
10620:
10615:
10603:
10598:
10593:
10588:
10583:
10578:
10573:
10568:
10563:
10558:
10553:
10548:
10543:
10538:
10533:
10528:
10523:
10518:
10513:
10508:
10503:
10498:
10493:
10488:
10483:
10478:
10473:
10468:
10463:
10458:
10453:
10441:
10436:
10431:
10426:
10421:
10416:
10411:
10406:
10401:
10396:
10391:
10386:
10381:
10376:
10371:
10366:
10361:
10352:
10350:
10333:
10319:
10318:
10315:
10314:
10312:
10311:
10306:
10301:
10296:
10291:
10286:
10281:
10276:
10271:
10266:
10261:
10256:
10251:
10246:
10241:
10236:
10231:
10226:
10221:
10216:
10211:
10206:
10201:
10196:
10191:
10186:
10181:
10176:
10171:
10166:
10161:
10156:
10151:
10146:
10141:
10136:
10131:
10126:
10121:
10116:
10111:
10106:
10100:
10098:
10094:
10093:
10091:
10090:
10085:
10080:
10075:
10070:
10065:
10060:
10055:
10050:
10045:
10040:
10035:
10031:
10027:
10022:
10017:
10012:
10007:
10002:
9997:
9992:
9987:
9982:
9977:
9972:
9967:
9962:
9957:
9952:
9947:
9942:
9937:
9932:
9927:
9918:
9917:
9912:
9907:
9903:
9899:
9894:
9890:
9882:
9880:
9871:
9865:
9864:
9862:
9861:
9852:
9851:
9846:
9841:
9836:
9831:
9826:
9821:
9817:
9812:
9808:
9803:
9798:
9796:Isocarbacyclin
9793:
9788:
9783:
9778:
9773:
9768:
9763:
9754:
9752:
9743:
9737:
9736:
9734:
9733:
9728:
9723:
9718:
9713:
9708:
9704:
9700:
9696:
9691:
9686:
9681:
9676:
9671:
9666:
9657:
9655:
9646:
9640:
9639:
9636:
9635:
9633:
9632:
9627:
9622:
9617:
9613:
9608:
9603:
9598:
9593:
9588:
9583:
9579:
9571:
9569:
9565:
9564:
9562:
9561:
9556:
9551:
9546:
9537:
9536:
9531:
9529:(dinoprostone)
9526:
9522:
9517:
9513:
9508:
9499:
9497:
9489:
9483:
9482:
9480:
9479:
9470:
9469:
9464:
9459:
9454:
9452:(dinoprostone)
9449:
9445:
9440:
9436:
9432:
9428:
9423:
9418:
9416:Isocarbacyclin
9413:
9408:
9403:
9398:
9393:
9384:
9382:
9374:
9368:
9367:
9365:
9364:
9359:
9354:
9345:
9344:
9339:
9337:(dinoprostone)
9334:
9330:
9325:
9321:
9316:
9307:
9305:
9297:
9291:
9290:
9288:
9287:
9282:
9277:
9272:
9267:
9258:
9257:
9252:
9250:(dinoprostone)
9247:
9243:
9238:
9234:
9229:
9224:
9219:
9214:
9209:
9200:
9198:
9190:
9181:
9172:
9166:
9165:
9162:
9161:
9159:
9158:
9153:
9148:
9143:
9138:
9133:
9128:
9123:
9118:
9113:
9108:
9103:
9094:
9093:
9089:
9085:
9076:
9074:
9066:
9060:
9059:
9057:
9056:
9051:
9046:
9037:
9036:
9031:
9027:
9019:
9017:
9009:
9000:
8991:
8982:
8968:
8967:
8954:
8953:
8946:
8939:
8931:
8922:
8921:
8918:
8917:
8916:
8915:
8912:
8901:
8895:
8889:
8888:
8885:
8884:
8882:
8881:
8876:
8871:
8866:
8861:
8859:Methoxyflurane
8856:
8851:
8846:
8841:
8836:
8831:
8826:
8821:
8816:
8810:
8808:
8804:
8803:
8801:
8800:
8795:
8790:
8785:
8780:
8775:
8769:
8767:
8761:
8760:
8757:
8756:
8754:
8753:
8747:
8745:
8739:
8738:
8736:
8735:
8730:
8725:
8717:
8712:
8711:
8701:
8696:
8691:
8677:
8672:
8666:
8664:
8658:
8657:
8655:
8654:
8649:
8644:
8639:
8634:
8629:
8624:
8618:
8616:
8607:
8599:
8598:
8596:
8595:
8590:
8585:
8580:
8575:
8569:
8567:
8561:
8560:
8557:
8556:
8554:
8553:
8548:
8543:
8538:
8533:
8528:
8522:
8520:
8516:
8515:
8513:
8512:
8502:Propyphenazone
8499:
8494:
8489:
8484:
8479:
8477:Aminophenazone
8473:
8471:
8465:
8464:
8462:
8461:
8448:
8443:
8438:
8433:
8428:
8423:
8418:
8413:
8408:
8403:
8398:
8393:
8388:
8383:
8378:
8373:
8368:
8357:
8355:
8349:
8348:
8346:
8345:
8340:
8338:Mefenamic acid
8335:
8330:
8324:
8322:
8316:
8315:
8313:
8312:
8307:
8302:
8297:
8292:
8287:
8273:
8271:
8265:
8264:
8262:
8261:
8256:
8251:
8246:
8241:
8228:
8223:
8218:
8213:
8207:
8205:
8201:
8200:
8198:
8197:
8192:
8187:
8182:
8177:
8171:
8169:
8165:
8164:
8162:
8161:
8156:
8151:
8146:
8141:
8136:
8131:
8118:
8097:
8092:
8087:
8081:
8079:
8072:
8066:
8065:
8063:
8062:
8057:
8052:
8047:
8046:
8045:
8040:
8035:
8030:
8025:
8020:
8015:
8010:
8000:
7995:
7990:
7984:
7982:
7975:
7974:
7971:
7970:
7968:
7967:
7962:
7945:
7940:
7935:
7930:
7925:
7920:
7915:
7910:
7905:
7900:
7895:
7890:
7885:
7880:
7875:
7870:
7865:
7860:
7855:
7850:
7845:
7835:
7830:
7825:
7820:
7815:
7810:
7808:Dextromoramide
7805:
7800:
7795:
7790:
7785:
7779:
7777:
7773:
7772:
7770:
7769:
7764:
7759:
7754:
7725:
7720:
7715:
7710:
7705:
7700:
7695:
7690:
7688:Hydromorphinol
7685:
7664:
7659:
7654:
7649:
7639:Dihydrocodeine
7636:
7631:
7626:
7621:
7608:
7606:Benzylmorphine
7603:
7597:
7595:
7591:
7590:
7588:
7587:
7582:
7577:
7572:
7562:
7561:
7560:
7555:
7544:
7542:
7529:
7523:
7522:
7506:
7505:
7498:
7491:
7483:
7474:
7473:
7471:
7470:
7460:
7450:
7439:
7436:
7435:
7431:veterinary use
7416:
7413:
7412:
7410:
7409:
7404:
7399:
7394:
7389:
7384:
7379:
7373:
7371:
7365:
7364:
7362:
7361:
7356:
7351:
7346:
7341:
7336:
7331:
7326:
7321:
7316:
7311:
7306:
7301:
7296:
7290:
7288:
7284:
7283:
7281:
7280:
7275:
7270:
7265:
7260:
7255:
7250:
7245:
7240:
7235:
7230:
7218:
7212:
7210:
7202:
7201:
7199:
7198:
7193:
7188:
7183:
7180:Mefenamic acid
7176:
7171:
7166:
7161:
7156:
7151:
7146:
7141:
7136:
7130:
7128:
7115:
7114:
7112:
7111:
7100:
7095:
7090:
7085:
7080:
7075:
7070:
7065:
7060:
7055:
7050:
7043:
7038:
7033:
7028:
7023:
7018:
7011:
7006:
7001:
6996:
6991:
6986:
6981:
6976:
6971:
6965:
6963:
6955:propionic acid
6951:
6950:
6948:
6947:
6942:
6937:
6930:
6925:
6920:
6915:
6910:
6904:
6902:
6896:
6895:
6893:
6892:
6887:
6882:
6877:
6872:
6867:
6862:
6857:
6852:
6847:
6842:
6837:
6832:
6827:
6822:
6820:Fenclozic acid
6817:
6812:
6807:
6802:
6795:
6790:
6785:
6780:
6775:
6770:
6765:
6760:
6754:
6752:
6743:
6742:
6740:
6739:
6734:
6729:
6724:
6719:
6714:
6709:
6704:
6699:
6694:
6689:
6684:
6679:
6674:
6669:
6661:
6659:
6653:
6652:
6650:
6649:
6644:
6642:Sulfinpyrazone
6639:
6637:Propyphenazone
6634:
6631:Phenylbutazone
6627:
6622:
6617:
6612:
6607:
6602:
6597:
6592:
6587:
6582:
6577:
6572:
6567:
6562:
6560:Aminophenazone
6556:
6554:
6543:
6542:
6522:
6521:
6514:
6507:
6499:
6490:
6489:
6486:
6485:
6484:
6483:
6480:
6469:
6463:
6457:
6456:
6453:
6452:
6449:
6448:
6446:
6445:
6440:
6435:
6430:
6425:
6420:
6415:
6410:
6405:
6400:
6395:
6390:
6385:
6380:
6375:
6370:
6365:
6359:
6348:
6343:
6338:
6333:
6328:
6323:
6318:
6313:
6308:
6303:
6298:
6293:
6288:
6283:
6278:
6273:
6268:
6263:
6258:
6253:
6248:
6243:
6238:
6233:
6228:
6223:
6218:
6213:
6208:
6203:
6198:
6193:
6188:
6172:
6167:
6162:
6156:
6154:
6150:
6149:
6147:
6146:
6134:
6122:
6109:
6107:
6101:
6100:
6098:
6097:
6091:
6086:
6081:
6076:
6064:
6058:
6053:
6048:
6043:
6032:
6026:
6021:
6013:
6006:PARP inhibitor
6002:
5990:
5978:
5966:
5965:
5964:
5959:
5954:
5949:
5937:
5931:
5926:
5921:
5916:
5902:
5889:
5887:
5878:
5874:
5873:
5871:
5870:
5864:
5859:
5854:
5843:
5838:
5833:
5828:
5822:
5820:
5810:
5809:
5806:
5805:
5802:
5801:
5799:
5798:
5792:
5787:
5782:
5772:
5770:
5764:
5763:
5761:
5760:
5754:
5749:
5738:
5733:
5728:
5723:
5711:
5705:
5703:
5697:
5696:
5694:
5693:
5688:
5683:
5678:
5673:
5668:
5662:
5660:
5658:Platinum-based
5654:
5653:
5651:
5650:
5645:
5640:
5635:
5623:
5622:
5616:
5600:
5599:
5594:
5589:
5584:
5574:
5569:
5557:
5556:
5551:
5546:
5536:
5531:
5525:
5516:
5511:
5499:
5497:
5488:
5476:
5475:
5472:
5471:
5469:
5468:
5463:
5458:
5453:
5448:
5442:
5437:
5426:
5420:
5415:
5410:
5405:
5400:
5395:
5385:
5380:
5373:Anthracyclines
5368:
5366:
5356:
5355:
5353:
5352:
5346:
5334:
5332:
5326:
5325:
5323:
5322:
5316:
5311:
5306:
5301:
5296:
5291:
5286:
5281:
5276:
5271:
5259:
5257:
5248:
5236:
5235:
5232:
5231:
5229:
5228:
5215:
5213:
5207:
5206:
5204:
5203:
5197:
5185:
5184:
5171:
5170:
5154:
5153:
5143:
5138:
5133:
5128:
5123:
5111:
5109:
5103:
5102:
5100:
5099:
5093:
5091:Mercaptopurine
5082:
5077:
5072:
5066:
5061:
5045:
5044:
5031:
5029:
5023:
5022:
5020:
5019:
5013:
5002:
4996:
4991:
4986:
4974:
4972:
4963:
4946:
4938:
4937:
4934:
4933:
4931:
4930:
4918:
4912:
4907:
4902:
4897:
4892:
4880:
4878:
4874:
4873:
4871:
4870:
4864:
4859:
4854:
4849:
4837:
4835:
4824:
4808:
4807:
4793:Intracellular
4790:
4789:
4782:
4775:
4767:
4761:
4760:
4744:
4726:
4725:External links
4723:
4721:
4720:
4691:
4663:
4661:
4658:
4655:
4654:
4613:
4586:(2): 197–208.
4570:
4526:
4495:
4444:
4415:(11): 1465–8.
4395:
4354:
4305:
4284:(10): 883–90.
4264:
4223:
4182:
4131:
4087:
4044:
4001:
3958:
3911:
3885:
3860:
3838:
3827:on 31 May 2014
3804:
3771:
3745:
3730:. 4 May 2020.
3715:
3693:
3658:
3625:
3591:
3560:
3514:
3480:
3467:
3436:
3421:
3392:
3379:
3364:. 1 May 2012.
3343:
3310:
3279:
3246:
3214:
3183:
3164:(12): 1541–4.
3145:
3126:(9): 1347–65.
3104:
3061:
3020:
3013:
2995:
2946:
2903:
2896:
2875:
2821:
2792:(3): 205–213.
2772:
2723:
2694:
2659:
2618:
2577:
2534:
2487:
2446:
2397:
2370:
2329:
2278:
2229:
2204:
2174:
2167:
2150:
2131:
2111:
2077:
2045:
1999:
1943:
1886:
1834:
1787:
1757:
1723:
1694:
1679:. 4 May 2020.
1660:
1659:
1657:
1654:
1610:
1607:
1593:
1590:
1581:
1578:
1569:
1566:
1549:
1546:
1544:
1541:
1521:
1518:
1477:
1474:
1472:
1469:
1465:Public Citizen
1336:
1333:
1323:
1319:
1286:
1283:
1271:
1268:
1264:stomach ulcers
1243:cyclooxygenase
1234:
1231:
1229:
1226:
1193:
1190:
1154:
1151:
1129:
1126:
1109:
1108:
1093:
1085:
1070:
1067:
1058:
1055:
1001:osteoarthritis
996:
993:
958:kidney failure
936:, nausea, and
934:abdominal pain
925:. It is taken
891:osteoarthritis
862:
861:
850:
849:
847:
846:
843:
841:
838:
830:
829:
828:
825:
824:
822:
821:
818:
810:
809:
808:
805:
804:
802:
801:
793:
791:
783:
782:
776:
770:
769:
763:
757:
751:
745:
739:
734:
728:
727:
723:
722:
712:
704:
703:
701:
700:
687:
685:
672:
671:
669:
668:
652:
650:
644:
643:
641:
640:
632:
630:
624:
623:
621:
620:
612:
610:
604:
603:
601:
600:
592:
590:
584:
583:
581:
580:
572:
570:
564:
563:
561:
560:
552:
550:
544:
543:
541:
540:
532:
530:
524:
523:
521:
520:
512:
510:
504:
503:
501:
500:
492:
490:
479:
478:
476:
475:
467:
465:
459:
458:
456:
455:
452:
444:
443:
442:
439:
438:
434:
433:
430:
424:
423:
420:
411:
410:
405:Liver (mainly
403:
397:
396:
389:
383:
382:
379:
373:
372:
365:
364:
362:
361:
358:
343:
330:
322:
311:
298:
284:
282:
276:
275:
271:
270:
268:
267:
244:
242:
236:
235:
230:
224:
223:
218:
216:administration
210:
209:
207:
206:
204:
194:
192:
184:
183:
181:
180:
162:
160:
154:
153:
146:
140:
139:
132:
122:
121:
118:
112:
111:
53:
49:
48:
44:
43:
35:
34:
15:
9:
6:
4:
3:
2:
11575:
11564:
11561:
11559:
11556:
11554:
11551:
11549:
11546:
11544:
11541:
11539:
11536:
11534:
11531:
11529:
11526:
11524:
11521:
11520:
11518:
11508:
11498:
11497:
11494:
11481:
11480:
11476:
11474:
11473:
11469:
11466:
11465:
11462:
11456:
11450:
11448:
11442:
11440:
11437:
11435:
11432:
11430:
11427:
11425:
11422:
11420:
11419:Linoleic acid
11417:
11414:
11413:
11411:
11407:
11397:
11394:
11392:
11389:
11387:
11384:
11382:
11379:
11377:
11374:
11372:
11369:
11367:
11364:
11362:
11359:
11357:
11354:
11352:
11349:
11347:
11344:
11342:
11339:
11337:
11334:
11332:
11329:
11327:
11324:
11322:
11319:
11318:
11316:
11311:
11305:
11301:
11297:
11292:
11282:
11278:
11274:
11269:
11263:
11259:
11255:
11250:
11244:
11237:
11233:
11229:
11225:
11222:
11220:
11217:
11216:
11214:
11209:
11199:
11193:
11190:
11188:
11185:
11183:
11180:
11178:
11175:
11173:
11170:
11168:
11165:
11163:
11160:
11158:
11155:
11153:
11150:
11148:
11145:
11143:
11140:
11138:
11135:
11133:
11130:
11128:
11125:
11123:
11120:
11118:
11115:
11113:
11110:
11108:
11101:
11099:
11096:
11094:
11091:
11089:
11086:
11084:
11081:
11079:
11076:
11074:
11071:
11069:
11066:
11064:
11061:
11059:
11056:
11054:
11051:
11049:
11046:
11044:
11041:
11039:
11036:
11032:
11029:
11027:
11024:
11022:
11019:
11017:
11014:
11012:
11009:
11007:
11004:
11002:
10999:
10997:
10994:
10992:
10989:
10987:
10984:
10982:
10979:
10977:
10974:
10972:
10969:
10967:
10964:
10960:
10957:
10955:
10952:
10950:
10947:
10945:
10942:
10940:
10937:
10935:
10932:
10930:
10927:
10923:
10920:
10918:
10915:
10911:
10908:
10906:
10903:
10901:
10898:
10894:
10891:
10889:
10888:Fluproquazone
10886:
10885:Quinazolines:
10882:
10879:
10877:
10874:
10872:
10869:
10865:
10862:
10860:
10857:
10855:
10852:
10850:
10847:
10845:
10842:
10840:
10837:
10835:
10832:
10830:
10827:
10823:
10820:
10818:
10815:
10813:
10810:
10808:
10805:
10803:
10800:
10796:
10793:
10791:
10788:
10786:
10783:
10781:
10778:
10776:
10773:
10771:
10768:
10766:
10763:
10761:
10758:
10756:
10753:
10749:
10746:
10744:
10741:
10739:
10736:
10734:
10731:
10729:
10726:
10724:
10721:
10719:
10716:
10714:
10711:
10709:
10706:
10704:
10701:
10699:
10696:
10694:
10691:
10689:
10686:
10684:
10681:
10679:
10676:
10674:
10671:
10669:
10666:
10664:
10663:Flunoxaprofen
10661:
10659:
10656:
10654:
10651:
10649:
10648:Dexketoprofen
10646:
10644:
10643:Dexindoprofen
10641:
10639:
10636:
10634:
10631:
10629:
10626:
10624:
10621:
10619:
10616:
10614:
10611:
10607:
10604:
10602:
10599:
10597:
10594:
10592:
10589:
10587:
10584:
10582:
10581:Proglumetacin
10579:
10577:
10574:
10572:
10569:
10567:
10564:
10562:
10559:
10557:
10554:
10552:
10549:
10547:
10544:
10542:
10539:
10537:
10534:
10532:
10529:
10527:
10524:
10522:
10519:
10517:
10514:
10512:
10511:Difenpiramide
10509:
10507:
10504:
10502:
10499:
10497:
10494:
10492:
10489:
10487:
10484:
10482:
10479:
10477:
10474:
10472:
10469:
10467:
10464:
10462:
10459:
10457:
10454:
10452:
10449:
10448:Acetic acids:
10445:
10442:
10440:
10437:
10435:
10432:
10430:
10427:
10425:
10422:
10420:
10417:
10415:
10412:
10410:
10407:
10405:
10402:
10400:
10397:
10395:
10392:
10390:
10387:
10385:
10382:
10380:
10377:
10375:
10372:
10370:
10367:
10365:
10362:
10360:
10357:
10354:
10353:
10351:
10349:
10337:
10334:
10330:
10324:
10320:
10310:
10307:
10305:
10302:
10300:
10297:
10295:
10292:
10290:
10287:
10285:
10282:
10280:
10277:
10275:
10272:
10270:
10267:
10265:
10262:
10260:
10257:
10255:
10252:
10250:
10247:
10245:
10242:
10240:
10237:
10235:
10232:
10230:
10227:
10225:
10222:
10220:
10217:
10215:
10212:
10210:
10207:
10205:
10202:
10200:
10197:
10195:
10192:
10190:
10187:
10185:
10182:
10180:
10179:Fenprostalene
10177:
10175:
10172:
10170:
10167:
10165:
10162:
10160:
10157:
10155:
10152:
10150:
10147:
10145:
10142:
10140:
10137:
10135:
10132:
10130:
10129:Delprostenate
10127:
10125:
10122:
10120:
10117:
10115:
10112:
10110:
10107:
10105:
10102:
10101:
10099:
10095:
10089:
10086:
10084:
10081:
10079:
10076:
10074:
10071:
10069:
10066:
10064:
10061:
10059:
10056:
10054:
10051:
10049:
10046:
10044:
10041:
10039:
10036:
10034:
10028:
10026:
10023:
10021:
10018:
10016:
10013:
10011:
10008:
10006:
10003:
10001:
9998:
9996:
9993:
9991:
9988:
9986:
9983:
9981:
9978:
9976:
9973:
9971:
9968:
9966:
9963:
9961:
9958:
9956:
9953:
9951:
9948:
9946:
9943:
9941:
9938:
9936:
9933:
9931:
9928:
9926:
9923:
9920:
9919:
9916:
9913:
9911:
9908:
9906:
9902:Thromboxane A
9900:
9898:
9895:
9893:
9887:
9884:
9883:
9881:
9876:
9866:
9860:
9857:
9854:
9853:
9850:
9847:
9845:
9842:
9840:
9837:
9835:
9832:
9830:
9827:
9825:
9824:(alprostadil)
9818:
9816:
9809:
9807:
9804:
9802:
9799:
9797:
9794:
9792:
9789:
9787:
9784:
9782:
9779:
9777:
9774:
9772:
9769:
9767:
9764:
9762:
9759:
9756:
9755:
9753:
9748:
9738:
9732:
9729:
9727:
9724:
9722:
9719:
9717:
9714:
9712:
9705:
9703:
9697:
9695:
9692:
9690:
9687:
9685:
9682:
9680:
9677:
9675:
9672:
9670:
9667:
9665:
9662:
9659:
9658:
9656:
9651:
9641:
9631:
9628:
9626:
9623:
9621:
9614:
9612:
9609:
9607:
9604:
9602:
9599:
9597:
9594:
9592:
9589:
9587:
9584:
9582:
9576:
9573:
9572:
9570:
9566:
9560:
9557:
9555:
9552:
9550:
9547:
9545:
9542:
9539:
9538:
9535:
9532:
9530:
9523:
9521:
9520:(alprostadil)
9514:
9512:
9509:
9507:
9504:
9501:
9500:
9498:
9493:
9484:
9478:
9475:
9472:
9471:
9468:
9465:
9463:
9460:
9458:
9455:
9453:
9446:
9444:
9443:(alprostadil)
9437:
9435:
9429:
9427:
9424:
9422:
9419:
9417:
9414:
9412:
9409:
9407:
9404:
9402:
9399:
9397:
9394:
9392:
9389:
9386:
9385:
9383:
9378:
9369:
9363:
9360:
9358:
9355:
9353:
9350:
9347:
9346:
9343:
9340:
9338:
9331:
9329:
9328:(alprostadil)
9322:
9320:
9317:
9315:
9312:
9309:
9308:
9306:
9301:
9292:
9286:
9283:
9281:
9278:
9276:
9273:
9271:
9268:
9266:
9263:
9260:
9259:
9256:
9253:
9251:
9244:
9242:
9241:(alprostadil)
9235:
9233:
9230:
9228:
9225:
9223:
9220:
9218:
9215:
9213:
9210:
9208:
9205:
9202:
9201:
9199:
9194:
9185:
9182:
9177:
9167:
9157:
9154:
9152:
9149:
9147:
9144:
9142:
9139:
9137:
9134:
9132:
9129:
9127:
9124:
9122:
9119:
9117:
9114:
9112:
9109:
9107:
9104:
9102:
9099:
9096:
9095:
9092:
9086:
9084:
9081:
9078:
9077:
9075:
9070:
9061:
9055:
9052:
9050:
9047:
9045:
9042:
9039:
9038:
9035:
9032:
9030:
9024:
9021:
9020:
9018:
9013:
9004:
9001:
8996:
8986:
8983:
8979:
8973:
8969:
8965:
8962:
8959:
8952:
8947:
8945:
8940:
8938:
8933:
8932:
8929:
8913:
8911:
8908:
8907:
8905:
8902:
8899:
8896:
8894:
8891:
8890:
8886:
8880:
8877:
8875:
8872:
8870:
8867:
8865:
8862:
8860:
8857:
8855:
8852:
8850:
8847:
8845:
8842:
8840:
8837:
8835:
8832:
8830:
8827:
8825:
8822:
8820:
8817:
8815:
8812:
8811:
8809:
8805:
8799:
8796:
8794:
8793:Methocarbamol
8791:
8789:
8788:Mephenoxalone
8786:
8784:
8781:
8779:
8778:Chlorzoxazone
8776:
8774:
8771:
8770:
8768:
8766:
8762:
8752:
8749:
8748:
8746:
8744:
8740:
8734:
8731:
8729:
8726:
8724:
8721:
8714:
8713:
8709:
8708:amitriptyline
8705:
8702:
8700:
8697:
8695:
8692:
8689:
8685:
8681:
8678:
8676:
8673:
8671:
8670:Carbamazepine
8668:
8667:
8665:
8663:
8659:
8653:
8650:
8648:
8645:
8643:
8640:
8638:
8635:
8633:
8630:
8628:
8625:
8623:
8620:
8619:
8617:
8615:
8611:
8608:
8606:
8600:
8594:
8591:
8589:
8586:
8584:
8581:
8579:
8576:
8574:
8571:
8570:
8568:
8566:
8562:
8552:
8549:
8547:
8544:
8542:
8539:
8537:
8534:
8532:
8529:
8527:
8524:
8523:
8521:
8517:
8510:
8503:
8500:
8498:
8495:
8493:
8490:
8488:
8485:
8483:
8480:
8478:
8475:
8474:
8472:
8470:
8466:
8459:
8452:
8449:
8447:
8444:
8442:
8439:
8437:
8434:
8432:
8429:
8427:
8424:
8422:
8419:
8417:
8414:
8412:
8409:
8407:
8404:
8402:
8399:
8397:
8394:
8392:
8389:
8387:
8384:
8382:
8379:
8377:
8374:
8372:
8369:
8366:
8362:
8359:
8358:
8356:
8354:
8350:
8344:
8341:
8339:
8336:
8334:
8331:
8329:
8326:
8325:
8323:
8321:
8317:
8311:
8308:
8306:
8303:
8301:
8298:
8296:
8293:
8291:
8288:
8285:
8278:
8275:
8274:
8272:
8270:
8266:
8260:
8257:
8255:
8252:
8250:
8247:
8245:
8242:
8239:
8232:
8229:
8227:
8224:
8222:
8219:
8217:
8214:
8212:
8209:
8208:
8206:
8202:
8196:
8193:
8191:
8188:
8186:
8183:
8181:
8178:
8176:
8173:
8172:
8170:
8166:
8160:
8157:
8155:
8152:
8150:
8147:
8145:
8142:
8140:
8137:
8135:
8132:
8129:
8128:Dexketoprofen
8122:
8119:
8116:
8108:
8101:
8098:
8096:
8093:
8091:
8088:
8086:
8083:
8082:
8080:
8076:
8073:
8071:
8067:
8061:
8058:
8056:
8053:
8051:
8048:
8044:
8041:
8039:
8036:
8034:
8031:
8029:
8026:
8024:
8021:
8019:
8016:
8014:
8011:
8009:
8006:
8005:
8004:
8001:
7999:
7996:
7994:
7991:
7989:
7986:
7985:
7983:
7980:
7976:
7966:
7963:
7960:
7956:
7949:
7946:
7944:
7941:
7939:
7936:
7934:
7931:
7929:
7926:
7924:
7921:
7919:
7916:
7914:
7911:
7909:
7906:
7904:
7903:Phenoperidine
7901:
7899:
7896:
7894:
7891:
7889:
7886:
7884:
7881:
7879:
7876:
7874:
7871:
7869:
7866:
7864:
7861:
7859:
7856:
7854:
7851:
7849:
7846:
7843:
7839:
7836:
7834:
7833:Ethoheptazine
7831:
7829:
7826:
7824:
7821:
7819:
7816:
7814:
7811:
7809:
7806:
7804:
7801:
7799:
7796:
7794:
7791:
7789:
7786:
7784:
7781:
7780:
7778:
7774:
7768:
7765:
7763:
7760:
7758:
7755:
7752:
7748:
7744:
7740:
7736:
7729:
7726:
7724:
7721:
7719:
7716:
7714:
7711:
7709:
7706:
7704:
7701:
7699:
7696:
7694:
7693:Hydromorphone
7691:
7689:
7686:
7683:
7679:
7675:
7668:
7665:
7663:
7662:Ethylmorphine
7660:
7658:
7655:
7653:
7650:
7647:
7640:
7637:
7635:
7632:
7630:
7627:
7625:
7622:
7619:
7612:
7611:Buprenorphine
7609:
7607:
7604:
7602:
7599:
7598:
7596:
7594:Semisynthetic
7592:
7586:
7583:
7581:
7578:
7576:
7573:
7570:
7566:
7563:
7559:
7556:
7554:
7551:
7550:
7549:
7546:
7545:
7543:
7541:
7537:
7533:
7530:
7528:
7524:
7519:
7515:
7511:
7504:
7499:
7497:
7492:
7490:
7485:
7484:
7481:
7469:
7465:
7461:
7459:
7451:
7449:
7441:
7440:
7437:
7432:
7428:
7424:
7420:
7414:
7408:
7405:
7403:
7400:
7398:
7395:
7393:
7390:
7388:
7385:
7383:
7380:
7378:
7375:
7374:
7372:
7366:
7360:
7357:
7355:
7352:
7350:
7347:
7345:
7342:
7340:
7337:
7335:
7332:
7330:
7327:
7325:
7322:
7320:
7317:
7315:
7314:Fluproquazone
7312:
7310:
7307:
7305:
7302:
7300:
7297:
7295:
7292:
7291:
7289:
7285:
7279:
7276:
7274:
7271:
7269:
7266:
7264:
7261:
7259:
7256:
7254:
7251:
7249:
7246:
7244:
7241:
7239:
7236:
7234:
7231:
7228:
7224:
7223:
7219:
7217:
7214:
7213:
7211:
7207:
7203:
7197:
7194:
7192:
7191:Niflumic acid
7189:
7187:
7184:
7182:
7181:
7177:
7175:
7172:
7170:
7167:
7165:
7162:
7160:
7157:
7155:
7152:
7150:
7147:
7145:
7142:
7140:
7137:
7135:
7132:
7131:
7129:
7126:
7120:
7116:
7110:
7106:
7105:
7101:
7099:
7096:
7094:
7091:
7089:
7086:
7084:
7081:
7079:
7076:
7074:
7071:
7069:
7066:
7064:
7061:
7059:
7056:
7054:
7051:
7049:
7048:
7044:
7042:
7039:
7037:
7034:
7032:
7029:
7027:
7024:
7022:
7019:
7017:
7016:
7012:
7010:
7007:
7005:
7004:Flunoxaprofen
7002:
7000:
6997:
6995:
6992:
6990:
6989:Dexketoprofen
6987:
6985:
6982:
6980:
6977:
6975:
6972:
6970:
6967:
6966:
6964:
6961:
6958:derivatives (
6956:
6952:
6946:
6943:
6941:
6938:
6936:
6935:
6931:
6929:
6926:
6924:
6921:
6919:
6916:
6914:
6911:
6909:
6906:
6905:
6903:
6901:
6897:
6891:
6888:
6886:
6883:
6881:
6878:
6876:
6873:
6871:
6870:Proglumetacin
6868:
6866:
6865:Prodolic acid
6863:
6861:
6858:
6856:
6853:
6851:
6848:
6846:
6843:
6841:
6838:
6836:
6833:
6831:
6828:
6826:
6823:
6821:
6818:
6816:
6813:
6811:
6808:
6806:
6805:Difenpiramide
6803:
6801:
6800:
6796:
6794:
6791:
6789:
6786:
6784:
6781:
6779:
6776:
6774:
6771:
6769:
6766:
6764:
6761:
6759:
6756:
6755:
6753:
6748:
6744:
6738:
6735:
6733:
6730:
6728:
6725:
6723:
6720:
6718:
6715:
6713:
6710:
6708:
6705:
6703:
6700:
6698:
6695:
6693:
6690:
6688:
6685:
6683:
6680:
6678:
6675:
6673:
6670:
6668:
6667:
6663:
6662:
6660:
6658:
6654:
6648:
6645:
6643:
6640:
6638:
6635:
6633:
6632:
6628:
6626:
6623:
6621:
6618:
6616:
6613:
6611:
6608:
6606:
6603:
6601:
6598:
6596:
6593:
6591:
6588:
6586:
6583:
6581:
6578:
6576:
6573:
6571:
6568:
6566:
6563:
6561:
6558:
6557:
6555:
6553:
6552:pyrazolidines
6548:
6544:
6539:
6535:
6531:
6527:
6520:
6515:
6513:
6508:
6506:
6501:
6500:
6497:
6481:
6479:
6476:
6475:
6473:
6470:
6467:
6464:
6462:
6459:
6458:
6454:
6444:
6441:
6439:
6436:
6434:
6431:
6429:
6426:
6424:
6421:
6419:
6416:
6414:
6411:
6409:
6406:
6404:
6401:
6399:
6396:
6394:
6391:
6389:
6386:
6384:
6381:
6379:
6376:
6374:
6371:
6369:
6366:
6363:
6360:
6358:
6354:
6353:
6349:
6347:
6346:Tabelecleucel
6344:
6342:
6339:
6337:
6334:
6332:
6329:
6327:
6324:
6322:
6319:
6317:
6314:
6312:
6309:
6307:
6306:Lurbinectedin
6304:
6302:
6299:
6297:
6294:
6292:
6289:
6287:
6284:
6282:
6279:
6277:
6274:
6272:
6269:
6267:
6264:
6262:
6259:
6257:
6254:
6252:
6249:
6247:
6244:
6242:
6239:
6237:
6234:
6232:
6229:
6227:
6224:
6222:
6219:
6217:
6214:
6212:
6209:
6207:
6204:
6202:
6199:
6197:
6194:
6192:
6189:
6186:
6182:
6178:
6177:
6173:
6171:
6168:
6166:
6163:
6161:
6158:
6157:
6155:
6151:
6144:
6140:
6139:
6135:
6132:
6128:
6127:
6123:
6120:
6116:
6115:
6111:
6110:
6108:
6106:
6102:
6095:
6092:
6090:
6087:
6085:
6082:
6080:
6077:
6075:
6071:
6069:
6065:
6062:
6059:
6057:
6054:
6052:
6049:
6047:
6044:
6042:
6038:
6037:
6033:
6030:
6027:
6025:
6022:
6020:
6017:
6014:
6012:
6008:
6007:
6003:
6000:
5996:
5995:
5991:
5988:
5984:
5983:
5979:
5976:
5972:
5971:
5967:
5963:
5960:
5958:
5955:
5953:
5950:
5948:
5945:
5944:
5943:
5942:
5938:
5935:
5932:
5930:
5927:
5925:
5922:
5920:
5917:
5915:
5911:
5910:
5907:
5903:
5900:
5896:
5895:
5891:
5890:
5888:
5886:
5882:
5879:
5875:
5868:
5865:
5863:
5860:
5858:
5855:
5853:
5849:
5848:
5844:
5842:
5839:
5837:
5834:
5832:
5829:
5827:
5824:
5823:
5821:
5819:
5815:
5811:
5796:
5793:
5791:
5788:
5786:
5783:
5781:
5777:
5774:
5773:
5771:
5769:
5768:Intercalation
5765:
5758:
5755:
5753:
5750:
5748:
5744:
5743:
5739:
5737:
5734:
5732:
5729:
5727:
5724:
5721:
5717:
5716:
5712:
5710:
5707:
5706:
5704:
5702:
5698:
5692:
5689:
5687:
5684:
5682:
5679:
5677:
5676:Dicycloplatin
5674:
5672:
5669:
5667:
5664:
5663:
5661:
5659:
5655:
5649:
5646:
5644:
5641:
5639:
5636:
5634:
5631:
5629:
5625:
5624:
5620:
5617:
5615:
5611:
5608:
5606:
5602:
5601:
5598:
5595:
5593:
5590:
5588:
5585:
5582:
5578:
5575:
5573:
5570:
5568:
5565:
5563:
5559:
5558:
5555:
5552:
5550:
5549:Prednimustine
5547:
5544:
5540:
5537:
5535:
5532:
5529:
5526:
5524:
5520:
5517:
5515:
5512:
5510:
5507:
5505:
5501:
5500:
5498:
5496:
5492:
5489:
5486:
5481:
5477:
5467:
5464:
5462:
5459:
5457:
5454:
5452:
5449:
5446:
5443:
5441:
5438:
5436:
5432:
5431:
5427:
5424:
5421:
5419:
5416:
5414:
5411:
5409:
5406:
5404:
5401:
5399:
5396:
5393:
5389:
5386:
5384:
5381:
5379:
5375:
5374:
5370:
5369:
5367:
5365:
5364:Intercalation
5361:
5357:
5350:
5347:
5345:
5341:
5340:
5336:
5335:
5333:
5331:
5327:
5320:
5317:
5315:
5312:
5310:
5307:
5305:
5302:
5300:
5297:
5295:
5292:
5290:
5287:
5285:
5282:
5280:
5277:
5275:
5272:
5270:
5266:
5265:
5261:
5260:
5258:
5256:
5252:
5249:
5246:
5241:
5237:
5226:
5222:
5221:
5217:
5216:
5214:
5212:
5208:
5201:
5198:
5196:
5192:
5191:
5187:
5186:
5182:
5178:
5177:
5173:
5172:
5168:
5167:+daunorubicin
5165:
5161:
5160:
5156:
5155:
5151:
5147:
5144:
5142:
5139:
5137:
5134:
5132:
5131:Doxifluridine
5129:
5127:
5124:
5122:
5118:
5117:
5113:
5112:
5110:
5108:
5104:
5097:
5094:
5092:
5088:
5087:
5083:
5081:
5080:Rabacfosadine
5078:
5076:
5073:
5070:
5067:
5065:
5062:
5060:
5056:
5055:
5051:
5047:
5046:
5042:
5038:
5037:
5033:
5032:
5030:
5028:
5024:
5017:
5014:
5012:
5008:
5007:
5003:
5000:
4997:
4995:
4992:
4990:
4987:
4985:
4981:
4980:
4976:
4975:
4973:
4971:
4967:
4964:
4961:
4956:
4950:
4947:
4943:
4939:
4928:
4924:
4923:
4919:
4916:
4913:
4911:
4908:
4906:
4903:
4901:
4898:
4896:
4893:
4891:
4887:
4886:
4882:
4881:
4879:
4875:
4868:
4865:
4863:
4860:
4858:
4855:
4853:
4850:
4848:
4844:
4843:
4839:
4838:
4836:
4833:
4828:
4825:
4822:
4817:
4813:
4809:
4804:
4800:
4796:
4788:
4783:
4781:
4776:
4774:
4769:
4768:
4765:
4757:
4755:
4749:
4745:
4741:
4739:
4733:
4729:
4728:
4717:
4713:
4709:
4705:
4701:
4697:
4692:
4688:
4684:
4680:
4676:
4675:
4670:
4665:
4664:
4650:
4646:
4641:
4636:
4632:
4628:
4624:
4617:
4609:
4605:
4601:
4597:
4593:
4589:
4585:
4581:
4574:
4566:
4562:
4557:
4552:
4548:
4544:
4540:
4533:
4531:
4522:
4518:
4514:
4510:
4506:
4499:
4491:
4487:
4482:
4477:
4472:
4467:
4463:
4459:
4455:
4448:
4440:
4436:
4431:
4426:
4422:
4418:
4414:
4410:
4406:
4399:
4391:
4387:
4382:
4377:
4373:
4369:
4365:
4358:
4350:
4346:
4341:
4336:
4332:
4328:
4324:
4320:
4316:
4309:
4301:
4297:
4292:
4287:
4283:
4279:
4275:
4268:
4260:
4256:
4251:
4246:
4243:(10): 891–9.
4242:
4238:
4234:
4227:
4219:
4215:
4210:
4205:
4202:(9): 873–84.
4201:
4197:
4193:
4186:
4178:
4174:
4169:
4164:
4160:
4156:
4153:(4): 507–17.
4152:
4148:
4147:
4142:
4135:
4127:
4123:
4119:
4115:
4111:
4107:
4104:(3): 163–79.
4103:
4099:
4091:
4083:
4079:
4075:
4071:
4067:
4063:
4059:
4055:
4048:
4040:
4036:
4032:
4028:
4024:
4020:
4016:
4012:
4005:
3997:
3993:
3989:
3985:
3981:
3977:
3973:
3969:
3962:
3954:
3950:
3946:
3942:
3938:
3934:
3930:
3926:
3918:
3916:
3899:
3895:
3889:
3874:
3870:
3864:
3848:
3842:
3826:
3822:
3820:
3814:
3808:
3792:
3788:
3787:
3782:
3775:
3759:
3755:
3749:
3733:
3729:
3725:
3719:
3711:
3707:
3705:
3697:
3681:
3677:
3676:
3670:
3662:
3646:
3642:
3641:
3636:
3629:
3613:
3609:
3605:
3598:
3596:
3579:
3575:
3571:
3564:
3548:
3544:
3543:
3538:
3531:
3529:
3527:
3525:
3523:
3521:
3519:
3502:
3498:
3496:
3490:
3484:
3477:
3471:
3455:
3451:
3445:
3443:
3441:
3434:
3428:
3426:
3409:
3405:
3399:
3397:
3389:
3383:
3367:
3363:
3359:
3358:
3353:
3347:
3331:
3327:
3326:
3321:
3314:
3298:
3294:
3290:
3283:
3267:
3263:
3262:
3261:The Scientist
3257:
3250:
3239:
3235:
3231:
3230:Chemical Bond
3224:
3218:
3202:
3198:
3194:
3187:
3179:
3175:
3171:
3167:
3163:
3159:
3152:
3150:
3141:
3137:
3133:
3129:
3125:
3121:
3113:
3111:
3109:
3100:
3096:
3092:
3088:
3084:
3080:
3076:
3072:
3065:
3057:
3053:
3048:
3043:
3039:
3035:
3031:
3024:
3016:
3010:
3006:
2999:
2991:
2987:
2982:
2977:
2973:
2969:
2965:
2961:
2957:
2950:
2942:
2938:
2934:
2930:
2926:
2922:
2919:(3): 233–52.
2918:
2914:
2907:
2899:
2897:9780071451536
2893:
2889:
2882:
2880:
2871:
2867:
2862:
2857:
2852:
2847:
2843:
2839:
2835:
2828:
2826:
2817:
2813:
2809:
2805:
2800:
2795:
2791:
2787:
2783:
2776:
2768:
2764:
2760:
2756:
2751:
2746:
2743:(6): 565–76.
2742:
2738:
2734:
2727:
2716:
2712:
2705:
2698:
2690:
2686:
2682:
2678:
2674:
2670:
2663:
2655:
2651:
2646:
2641:
2638:(3): 157–64.
2637:
2633:
2629:
2622:
2614:
2610:
2605:
2600:
2596:
2592:
2588:
2581:
2574:
2573:public domain
2555:
2551:
2547:
2541:
2539:
2531:
2530:public domain
2512:
2508:
2506:
2500:
2494:
2492:
2483:
2479:
2474:
2469:
2465:
2461:
2457:
2450:
2442:
2438:
2433:
2428:
2424:
2420:
2416:
2412:
2408:
2401:
2393:
2389:
2385:
2381:
2374:
2366:
2362:
2357:
2352:
2348:
2344:
2340:
2333:
2325:
2321:
2316:
2311:
2306:
2301:
2298:(1): 135–40.
2297:
2293:
2289:
2282:
2274:
2270:
2265:
2260:
2256:
2252:
2248:
2244:
2240:
2233:
2218:
2214:
2208:
2192:
2188:
2184:
2178:
2170:
2168:9780857113382
2164:
2160:
2154:
2138:
2134:
2132:9783527607495
2128:
2124:
2123:
2115:
2099:
2095:
2091:
2084:
2082:
2065:
2061:
2060:
2055:
2049:
2041:
2037:
2032:
2027:
2023:
2019:
2015:
2008:
2006:
2004:
1995:
1991:
1986:
1981:
1977:
1973:
1969:
1965:
1961:
1954:
1952:
1950:
1948:
1931:
1927:
1923:
1917:
1915:
1913:
1911:
1909:
1907:
1905:
1903:
1901:
1899:
1897:
1895:
1893:
1891:
1882:
1878:
1874:
1870:
1866:
1862:
1858:
1854:
1847:
1845:
1843:
1841:
1839:
1822:
1818:
1814:
1808:
1806:
1804:
1802:
1800:
1798:
1796:
1794:
1792:
1775:
1771:
1767:
1761:
1745:
1741:
1737:
1733:
1727:
1712:
1708:
1704:
1698:
1682:
1678:
1674:
1668:
1666:
1661:
1653:
1651:
1646:
1642:
1638:
1633:
1631:
1630:Karen Seibert
1627:
1626:
1621:
1615:
1606:
1603:
1599:
1589:
1587:
1577:
1575:
1565:
1563:
1562:schizophrenia
1559:
1555:
1540:
1538:
1533:
1531:
1525:
1517:
1514:
1510:
1506:
1502:
1497:
1495:
1491:
1486:
1482:
1468:
1466:
1447:
1444:
1438:
1435:
1431:
1427:
1422:
1418:
1414:
1410:
1406:
1402:
1397:
1395:
1391:
1387:
1383:
1379:
1374:
1372:
1368:
1364:
1360:
1356:
1352:
1348:
1342:
1332:
1328:
1312:
1305:
1298:
1291:
1282:
1280:
1275:
1267:
1265:
1261:
1257:
1253:
1248:
1244:
1240:
1225:
1223:
1219:
1215:
1211:
1207:
1203:
1199:
1189:
1187:
1183:
1182:meta-analysis
1178:
1177:
1171:
1168:
1164:
1159:
1150:
1148:
1144:
1140:
1135:
1125:
1122:
1118:
1113:
1106:
1102:
1098:
1094:
1091:
1086:
1082:
1078:
1073:
1072:
1066:
1064:
1054:
1051:
1049:
1045:
1040:
1038:
1034:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
1002:
992:
986:
981:
979:
978:breastfeeding
975:
971:
967:
963:
959:
955:
951:
947:
943:
942:heart attacks
939:
935:
930:
928:
924:
920:
916:
912:
908:
904:
900:
896:
892:
888:
884:
880:
876:
872:
868:
858:
851:
842:
837:
836:
833:
826:
817:
816:
813:
806:
799:
795:
794:
792:
789:
784:
777:
775:
771:
735:
733:
729:
724:
720:
716:
713:
711:
709:ECHA InfoCard
705:
697:
693:
692:DTXSID0022777
689:
688:
686:
677:
673:
665:
664:RCSB PDB
659:
654:
653:
651:
649:
645:
638:
634:
633:
631:
629:
625:
618:
614:
613:
611:
609:
605:
598:
594:
593:
591:
589:
585:
578:
574:
573:
571:
569:
565:
558:
554:
553:
551:
549:
545:
538:
534:
533:
531:
529:
525:
518:
514:
513:
511:
509:
505:
498:
494:
493:
491:
484:
480:
473:
469:
468:
466:
464:
460:
451:
450:
447:
440:
435:
431:
429:
425:
421:
419:
412:
408:
404:
402:
398:
394:
393:serum albumin
390:
388:
384:
380:
378:
374:
370:
366:
359:
356:
344:
341:
331:
323:
321:
312:
309:
299:
296:
286:
285:
283:
281:
277:
272:
264:
259:
254:
249:
246:
245:
243:
241:
237:
234:
231:
229:
225:
222:
219:
217:
211:
205:
196:
195:
193:
191:
185:
178:
173:
164:
163:
161:
159:
155:
151:
147:
145:
141:
137:
133:
131:
127:
123:
119:
117:
113:
109:
108:
95:
54:
52:Pronunciation
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
11553:Sulfonamides
11477:
11470:
11415:
11034:
10970:
10962:
10959:Propacetamol
10949:Parapropamol
10925:
10913:
10896:
10884:
10876:Floctafenine
10867:
10825:
10802:Azapropazone
10799:Pyrazolones:
10798:
10751:
10733:Tarenflurbil
10668:Flurbiprofen
10638:Dexibuprofen
10618:Benoxaprofen
10613:Alminoprofen
10609:
10536:Glucametacin
10447:
10424:Salicylamide
10414:Salacetamide
10355:
10304:Trimoprostil
10299:Tiprostanide
10284:Spiriprostil
10219:Naxaprostene
10169:Esuberaprost
10124:Cobiprostone
9922:Antagonists:
9921:
9885:
9856:Antagonists:
9855:
9849:Treprostinil
9757:
9689:Fluprostenol
9679:Cloprostenol
9660:
9574:
9541:Antagonists:
9540:
9506:Lubiprostone
9502:
9474:Antagonists:
9473:
9387:
9349:Antagonists:
9348:
9342:Treprostinil
9310:
9262:Antagonists:
9261:
9227:Lubiprostone
9203:
9098:Antagonists:
9097:
9079:
9041:Antagonists:
9040:
9034:Treprostinil
9022:
8798:Orphenadrine
8773:Carisoprodol
8765:Myorelaxants
8715:
8565:Cannabinoids
8531:Floctafenine
8436:Salicylamide
8276:
8115:+paracetamol
8107:Dexibuprofen
8095:Flurbiprofen
8085:Benoxaprofen
8060:Propacetamol
8050:Parapropamol
8018:+hydrocodone
7959:+paracetamol
7928:Remifentanil
7918:Proheptazine
7848:Ketobemidone
7788:Alphaprodine
7735:+paracetamol
7723:Nicomorphine
7718:Nicodicodine
7674:+paracetamol
7646:+paracetamol
7629:Desomorphine
7558:+paracetamol
7418:
7370:combinations
7221:
7220:
7186:Morniflumate
7178:
7149:Floctafenine
7134:Azapropazone
7118:
7102:
7078:Tarenflurbil
7063:Piketoprofen
7058:Pelubiprofen
7045:
7013:
7009:Flurbiprofen
6984:Dexibuprofen
6974:Benoxaprofen
6969:Alminoprofen
6932:
6797:
6727:Salicylamide
6664:
6629:
6605:Mofebutazone
6585:Famprofazone
6580:Difenamizole
6570:Azapropazone
6393:Tazemetostat
6357:Alitretinoin
6350:
6261:Estramustine
6241:Elsamitrucin
6231:Eflornithine
6210:
6185:Pegaspargase
6181:Asparaginase
6174:
6143:Testolactone
6136:
6124:
6112:
6066:
6051:Panobinostat
6034:
6004:
5992:
5980:
5968:
5939:
5904:
5892:
5845:
5841:Padeliporfin
5780:Dactinomycin
5776:Streptomyces
5757:Temozolomide
5752:Mitozolomide
5740:
5731:Mitobronitol
5720:Procarbazine
5713:
5701:Nonclassical
5626:
5603:
5597:Streptozocin
5562:Nitrosoureas
5560:
5534:Chlorambucil
5528:Trofosfamide
5514:Chlormethine
5509:Bendamustine
5502:
5440:Mitoxantrone
5435:Losoxantrone
5428:
5388:Daunorubicin
5371:
5337:
5274:Camptothecin
5262:
5218:
5188:
5174:
5157:
5141:Fluorouracil
5121:Capecitabine
5114:
5084:
5048:
5034:
5004:
4999:Pralatrexate
4989:Methotrexate
4977:
4920:
4883:
4840:
4751:
4735:
4699:
4695:
4673:
4630:
4626:
4616:
4583:
4579:
4573:
4546:
4542:
4512:
4508:
4498:
4461:
4457:
4447:
4412:
4408:
4398:
4374:(6): 431–6.
4371:
4367:
4357:
4325:(5): 672–4.
4322:
4318:
4308:
4281:
4277:
4267:
4240:
4236:
4226:
4199:
4195:
4185:
4150:
4144:
4134:
4101:
4097:
4090:
4057:
4053:
4047:
4014:
4010:
4004:
3971:
3967:
3961:
3928:
3924:
3902:. Retrieved
3897:
3888:
3876:. Retrieved
3872:
3863:
3851:. Retrieved
3841:
3829:. Retrieved
3825:the original
3816:
3807:
3795:. Retrieved
3784:
3774:
3762:. Retrieved
3748:
3736:. Retrieved
3727:
3718:
3710:the original
3703:
3696:
3684:. Retrieved
3673:
3661:
3649:. Retrieved
3638:
3628:
3616:. Retrieved
3607:
3582:. Retrieved
3573:
3563:
3551:. Retrieved
3540:
3505:. Retrieved
3492:
3483:
3470:
3458:. Retrieved
3412:. Retrieved
3382:
3370:. Retrieved
3355:
3346:
3334:. Retrieved
3323:
3313:
3301:. Retrieved
3293:Deseret News
3292:
3282:
3270:. Retrieved
3266:the original
3259:
3249:
3238:the original
3233:
3229:
3217:
3205:. Retrieved
3196:
3186:
3161:
3157:
3123:
3119:
3077:(2): 211–9.
3074:
3070:
3064:
3037:
3033:
3023:
3004:
2998:
2963:
2959:
2949:
2916:
2912:
2906:
2887:
2841:
2837:
2789:
2785:
2775:
2740:
2736:
2726:
2715:the original
2697:
2675:(8): 954–9.
2672:
2668:
2662:
2635:
2631:
2621:
2594:
2590:
2580:
2558:. Retrieved
2549:
2515:. Retrieved
2502:
2463:
2459:
2449:
2414:
2410:
2400:
2383:
2379:
2373:
2346:
2342:
2332:
2295:
2292:Rheumatology
2291:
2281:
2246:
2242:
2232:
2220:. Retrieved
2216:
2207:
2195:. Retrieved
2186:
2177:
2158:
2153:
2141:. Retrieved
2121:
2114:
2102:. Retrieved
2068:. Retrieved
2057:
2048:
2021:
2017:
1967:
1963:
1934:. Retrieved
1925:
1856:
1852:
1825:. Retrieved
1816:
1778:. Retrieved
1769:
1760:
1748:. Retrieved
1726:
1714:. Retrieved
1706:
1697:
1685:. Retrieved
1676:
1645:cell culture
1634:
1623:
1616:
1612:
1595:
1583:
1571:
1551:
1534:
1526:
1523:
1498:
1479:
1448:
1439:
1429:
1398:
1393:
1375:
1365:division of
1344:
1329:
1316:
1276:
1273:
1256:inflammation
1236:
1195:
1174:
1172:
1160:
1156:
1131:
1114:
1110:
1081:hypertension
1077:hypertension
1060:
1052:
1041:
1021:menstruation
998:
995:Medical uses
982:
931:
887:inflammation
870:
866:
865:
854:
415:Elimination
280:Legal status
274:Legal status
158:License data
18:
11416:Precursors:
11356:Nicogrelate
11336:Furegrelate
11277:Bimatoprost
11187:Trifenagrel
11177:Tiflamizole
11147:Rutecarpine
11132:Resveratrol
11073:Glimepiride
11038:Anitrazafen
11016:Robenacoxib
10996:Lumiracoxib
10929:Acetanilide
10871:Antrafenine
10829:Ampiroxicam
10723:Pranoprofen
10708:Naproxcinod
10601:Zidometacin
10526:Fenclofenac
10451:Aceclofenac
10389:Ethenzamide
10384:Dipyrocetyl
10279:Rosaprostol
10259:Posaraprost
10244:Penprostene
10234:Ornoprostil
10214:Mexiprostil
10209:Meteneprost
10164:Eptaloprost
10139:Dimoxaprost
10104:Arbaprostil
10058:Seratrodast
9950:BMS-180,291
9781:Carbacyclin
9731:Unoprostone
9711:(dinoprost)
9694:Latanoprost
9669:Bimatoprost
9664:Alfaprostol
9620:(dinoprost)
9559:ONO-AE3-208
9511:Misoprostol
9467:Sulprostone
9457:Remiprostol
9426:Misoprostol
9421:Latanoprost
9396:Carbacyclin
9357:PF-04418948
9319:Misoprostol
9255:Sulprostone
9232:Misoprostol
9222:Latanoprost
9156:Vidupiprant
9146:Timapiprant
9141:Setipiprant
9116:Fevipiprant
9083:Indometacin
9054:Vidupiprant
9049:Laropiprant
8900:from market
8844:Frunevetmab
8824:Bedinvetmab
8733:PF-05089771
8642:Mirogabalin
8603:Ion channel
8573:Cannabidiol
8526:Benzydamine
8469:Pyrazolones
8451:Wintergreen
8401:Ethenzamide
8396:Dipyrocetyl
8353:Salicylates
8295:Lumiracoxib
8231:Indometacin
8159:Zaltoprofen
8078:Propionates
7988:Acetanilide
7979:Paracetamol
7913:Piritramide
7898:Phenazocine
7893:Phenadoxone
7883:Pentazocine
7878:Oliceridine
7873:Norpipanone
7842:+fluanisone
7823:Dimenoxadol
7803:Carfentanil
7798:Bezitramide
7793:Anileridine
7762:Papaveretum
7757:Oxymorphone
7751:+naltrexone
7713:Nicocodeine
7698:Levorphanol
7667:Hydrocodone
7624:Butorphanol
7569:+naltrexone
7319:Glucosamine
7299:Benzydamine
7268:Robenacoxib
7253:Lumiracoxib
7144:Etofenamate
7109:Naproxcinod
7098:Zaltoprofen
6908:Ampiroxicam
6830:Indometacin
6758:Aceclofenac
6749:derivatives
6747:acetic acid
6697:Ethenzamide
6692:Dipyrocetyl
6657:salicylates
6547:pyrazolones
6468:from market
6438:Vorasidenib
6418:Trabectedin
6403:Tiazofurine
6398:Tebentafusp
6383:Tagraxofusp
6341:Plitidepsin
6311:Mitoguazone
6251:Epacadostat
6221:Demecolcine
6165:Aflibercept
6138:Sex steroid
6011:Fuzuloparib
5952:Carfilzomib
5924:Palbociclib
5914:Abemaciclib
5867:Verteporfin
5831:Efaproxiral
5747:Dacarbazine
5709:Altretamine
5691:Satraplatin
5686:Oxaliplatin
5666:Carboplatin
5643:Triaziquone
5614:Mannosulfan
5592:Ranimustine
5572:Fotemustine
5413:Pirarubicin
5398:Doxorubicin
5392:+cytarabine
5378:Aclarubicin
5339:Podophyllum
5264:Camptotheca
5195:Azacitidine
5181:Gemcitabine
5136:Floxuridine
5069:Fludarabine
5064:Clofarabine
5050:Halogenated
5041:Pentostatin
5016:Raltitrexed
4984:Aminopterin
4927:Ixabepilone
4922:Epothilones
4890:Cabazitaxel
4867:Vinorelbine
4852:Vincristine
4847:Vinblastine
4832:microtubule
4368:Cancer Cell
3931:: 230–238.
3764:10 November
3724:"Celecoxib"
3651:27 December
3618:21 February
3584:21 February
3553:27 December
3460:28 December
3414:31 December
3303:23 November
3272:11 November
2315:10072/15035
2070:27 December
2018:Circulation
1520:Brand names
1371:John Talley
1279:Cadherin-11
1270:Anti-cancer
1241:isoform of
1210:angiotensin
1202:fluconazole
1134:sulfonamide
1048:paracetamol
962:anaphylaxis
897:in adults,
781: g·mol
715:100.211.644
617:CHEBI:41423
472:169590-42-5
437:Identifiers
144:MedlinePlus
116:Trade names
11517:Categories
11386:Samixogrel
11381:Rolafagrel
11366:Picotamide
11346:Midazogrel
11321:Camonagrel
11182:Timegadine
11127:Pamicogrel
11098:Licofelone
11078:Hyperforin
11043:Clobuzarit
11031:Valdecoxib
11026:Tilmacoxib
11011:Polmacoxib
10986:Etoricoxib
10954:Phenacetin
10922:Nimesulide
10900:Clonixeril
10893:Proquazone
10849:Lornoxicam
10748:Vedaprofen
10698:Miroprofen
10693:Loxoprofen
10688:Ketoprofen
10683:Indoprofen
10658:Fenoprofen
10571:Oxametacin
10566:Nabumetone
10506:Diclofenac
10501:Clometacin
10496:Cinmetacin
10491:Bumadizone
10471:Alclofenac
10456:Acemetacin
10394:Guacetisal
10379:Diflunisal
10329:inhibitors
10294:Tilsuprost
10274:Rivenprost
10269:Rioprostil
10264:Prostalene
10249:Pimilprost
10239:Oxoprostol
10229:Nocloprost
10204:Luprostiol
10194:Lanproston
10189:Froxiprost
10184:Flunoprost
10174:Etiproston
10159:Enisoprost
10154:Eganoprost
10114:Ciprostene
10083:Terutroban
10073:Sulotroban
10053:Samixogrel
10038:Ramatroban
10025:Picotamide
10010:Mipitroban
10005:Linotroban
9990:Imitrodast
9980:ICI-192605
9975:ICI-185282
9960:Domitroban
9940:Argatroban
9839:Taprostene
9761:ACT-333679
9726:Travoprost
9721:Tafluprost
9716:Sulotroban
9674:Carboprost
9630:Taprenepag
9611:Omidenepag
9606:Nocloprost
9596:Evatanepag
9591:Carboprost
9544:Grapiprant
9136:Ramatroban
9044:Asapiprant
8964:modulators
8958:Prostanoid
8874:Rimazolium
8869:Proglumide
8814:Analgecine
8751:Flupirtine
8694:Mexiletine
8675:Lacosamide
8652:Ziconotide
8647:Pregabalin
8637:Leconotide
8627:Gabapentin
8605:modulators
8588:Nabiximols
8551:Proquazone
8546:Nimesulide
8541:Nabumetone
8492:Nifenazone
8406:Guacetisal
8391:Diflunisal
8376:Benorylate
8310:Valdecoxib
8290:Etoricoxib
8221:Diclofenac
8211:Acemetacin
8180:Lornoxicam
8134:Loxoprofen
8121:Ketoprofen
8090:Fenoprofen
8055:Phenacetin
8033:+oxycodone
8023:+ibuprofen
7955:+celecoxib
7938:Tapentadol
7933:Sufentanil
7908:Piminodine
7858:Meptazinol
7853:Lofentanil
7828:Dipipanone
7783:Alfentanil
7743:+ibuprofen
7708:Nalbuphine
7678:+ibuprofen
7510:Analgesics
7349:Proquazone
7339:Nimesulide
7334:Nabumetone
7329:Hyperforin
7278:Valdecoxib
7243:Etoricoxib
7093:Vedaprofen
7041:Miroprofen
7036:Loxoprofen
7031:Ketoprofen
7026:Indoprofen
6999:Fenoprofen
6923:Lornoxicam
6860:Oxametacin
6799:Diclofenac
6793:Bumadizone
6768:Alclofenac
6763:Acemetacin
6702:Guacetisal
6687:Diflunisal
6677:Benorylate
6647:Suxibuzone
6615:Nifenazone
6600:Metamizole
6433:Verdinexor
6428:Venetoclax
6331:Oblimersen
6326:Navitoclax
6301:Lucanthone
6296:Lonidamine
6286:Lifileucel
6281:Ivosidenib
6276:Imetelstat
6246:Enasidenib
6236:Elesclomol
6201:Bexarotene
6196:Belzutifan
6131:Bexarotene
6119:Atrasentan
6094:Umbralisib
6089:Idelalisib
6079:Copanlisib
6061:Vorinostat
6056:Romidepsin
6046:Entinostat
6041:Belinostat
5999:Masoprocol
5987:Tiazofurin
5975:Anagrelide
5947:Bortezomib
5934:Seliciclib
5929:Ribociclib
5909:inhibitors
5899:Tipifarnib
5862:Temoporfin
5857:Talaporfin
5795:Plicamycin
5790:Mitomycins
5736:Pipobroman
5715:Hydrazines
5681:Nedaplatin
5633:Carboquone
5628:Aziridines
5619:Treosulfan
5567:Carmustine
5554:Uramustine
5523:Ifosfamide
5495:Alkylating
5456:Bisantrene
5445:Pixantrone
5418:Valrubicin
5408:Idarubicin
5403:Epirubicin
5349:Teniposide
5304:Lurtotecan
5299:Irinotecan
5200:Decitabine
5164:Cytarabine
5107:Pyrimidine
5096:Tioguanine
5086:Thiopurine
5075:Nelarabine
5059:Cladribine
5011:Pemetrexed
4994:Pemetrexed
4970:Folic acid
4910:Paclitaxel
4862:Vinflunine
4633:(4): E21.
3974:: 146–53.
3869:"Celebrex"
2844:: 480291.
2560:15 October
2517:15 October
2222:14 January
2197:14 January
2143:13 October
1716:22 October
1656:References
1548:Psychiatry
1351:valdecoxib
1339:See also:
1220:, such as
1214:lisinopril
1198:cytochrome
1121:drug label
1019:, painful
1013:acute pain
976:or during
895:acute pain
786:3D model (
774:Molar mass
648:PDB ligand
577:JCX84Q7J1L
548:ChemSpider
508:IUPHAR/BPS
463:CAS Number
446:IUPAC name
401:Metabolism
228:Drug class
11548:Pyrazoles
11391:Terbogrel
11371:Pirmagrel
11331:Dazoxiben
11326:Dazmegrel
11219:Retinoids
11137:Romazarit
11083:Itazigrel
11068:FR-122047
11063:Flumizole
11021:Rofecoxib
11006:Parecoxib
11001:Mavacoxib
10991:Firocoxib
10981:Deracoxib
10976:Cimicoxib
10971:Celecoxib
10966:Apricoxib
10917:Flosulide
10881:Glafenine
10864:Tenoxicam
10859:Piroxicam
10854:Meloxicam
10738:Tepoxalin
10718:Pirprofen
10713:Oxaprozin
10678:Ibuproxam
10673:Ibuprofen
10633:Carprofen
10628:Butibufen
10606:Zomepirac
10576:Oxindanac
10561:Mofezolac
10556:Lonazolac
10551:Ketorolac
10531:Fentiazac
10486:Bufexamac
10481:Bromfenac
10461:Aclofenac
10444:Triflusal
10434:Salsalate
10359:Aloxiprin
10309:Viprostol
10254:Piriprost
10224:Nileprost
10199:Limaprost
10149:Ecraprost
10144:Doxaprost
10134:Deprostil
10119:Clinprost
10078:Terbogrel
10068:SQ-29,548
10063:SQ-28,668
10020:ONO-11120
9985:Ifetroban
9955:Daltroban
9945:Bay U3405
9915:Vapiprost
9886:Agonists:
9859:RO1138452
9834:Selexipag
9829:Ralinepag
9786:Cicaprost
9776:BMY-45778
9771:Beraprost
9758:Agonists:
9684:Enprostil
9661:Agonists:
9625:Simenepag
9601:Gemeprost
9575:Agonists:
9549:GW-627368
9503:Agonists:
9406:Enprostil
9401:Cicaprost
9391:Beraprost
9388:Agonists:
9314:Butaprost
9311:Agonists:
9212:Enprostil
9207:Beraprost
9204:Agonists:
9111:Bay U3405
9080:Agonists:
9023:Agonists:
8961:signaling
8910:Phase III
8898:Withdrawn
8879:Tanezumab
8839:Clonidine
8834:Capsaicin
8688:lidocaine
8536:Glafenine
8497:Phenazone
8441:Salsalate
8371:Aloxiprin
8320:Fenamates
8305:Rofecoxib
8300:Parecoxib
8284:+tramadol
8277:Celecoxib
8259:Zomepirac
8244:Ketorolac
8216:Bromfenac
8195:Tenoxicam
8190:Piroxicam
8185:Meloxicam
8144:Oxaprozin
8100:Ibuprofen
8043:+tramadol
7998:Butacetin
7863:Methadone
7776:Synthetic
7747:+naloxone
7728:Oxycodone
7657:Etorphine
7618:+naloxone
7585:Paregoric
7419:underline
7344:Oxaceprol
7309:Diacerein
7273:Rofecoxib
7263:Parecoxib
7258:Mavacoxib
7248:Firocoxib
7238:Deracoxib
7233:Cimicoxib
7227:+tramadol
7222:Celecoxib
7216:Apricoxib
7169:Glafenine
7164:Flutiazin
7125:fenamates
7083:Tepoxalin
7068:Pirprofen
7053:Oxaprozin
7021:Ibuproxam
7015:Ibuprofen
6979:Carprofen
6945:Tenoxicam
6940:Pivoxicam
6934:Piroxicam
6928:Meloxicam
6890:Zomepirac
6855:Mofezolac
6850:Lonazolac
6845:Ketorolac
6825:Fentiazac
6788:Bufexamac
6783:Bromfenac
6717:Salsalate
6672:Aloxiprin
6625:Phenazone
6590:Feprazone
6575:Clofezone
6478:Phase III
6466:Withdrawn
6443:Vosaroxin
6423:Veliparib
6378:Sotorasib
6368:Selinexor
6362:Tretinoin
6352:Retinoids
6266:Glasdegib
6211:Celecoxib
6160:Adagrasib
6084:Duvelisib
6074:Alpelisib
6029:Rucaparib
6016:Niraparib
5957:Oprozomib
5919:Alvocidib
5785:Bleomycin
5742:Triazenes
5726:Etoglucid
5671:Cisplatin
5587:Nimustine
5581:Semustine
5577:Lomustine
5539:Melphalan
5466:Menogaril
5461:Crisnatol
5451:Amsacrine
5423:Zorubicin
5383:Amrubicin
5344:Etoposide
5319:Topotecan
5314:Silatecan
5309:Rubitecan
5294:Gimatecan
5279:Cositecan
5269:Belotecan
4945:inhibitor
4915:Tesetaxel
4905:Ortataxel
4900:Larotaxel
4895:Docetaxel
4857:Vindesine
4464:(1): 38.
4060:: 23–34.
4017:: 79–85.
3953:237485915
3728:Drugs.com
1926:Drugs.com
1750:16 August
1677:Drugs.com
1485:Pharmacia
1426:Pharmacia
1421:Pharmacia
1359:mavacoxib
1355:parecoxib
1218:diuretics
1163:rofecoxib
1044:ibuprofen
974:pregnancy
966:ibuprofen
867:Celecoxib
637:ChEMBL118
428:Excretion
417:half-life
214:Routes of
188:Pregnancy
177:Celecoxib
136:Monograph
130:Drugs.com
23:Celecoxib
11507:Medicine
11467:See also
11376:Ridogrel
11351:Nafagrel
11341:Isbogrel
11224:Selenium
11192:Tropesin
11167:SC-58125
11152:Satigrel
11117:NCX-4040
11093:L-670596
11088:L-655240
11048:Curcumin
10910:Flunixin
10905:Clonixin
10844:Isoxicam
10839:Enolicam
10834:Droxicam
10812:Isopyrin
10807:Dipyrone
10728:Suprofen
10703:Naproxen
10653:Fenbufen
10596:Tolmetin
10586:Sulindac
10521:Felbinac
10516:Etodolac
10476:Bendazac
10289:Tiaprost
10109:Ataprost
10097:Unsorted
10043:Ridogrel
10015:ONO-3708
10000:L-670596
9995:L-655240
9970:GR-32191
9586:Aganepag
9568:Unsorted
9554:L-161982
9534:TCS-2510
9477:L-798106
9362:TG 4-155
9285:SC-51322
9280:SC-51089
9275:SC-19220
9270:ONO-8130
9106:AZD-1981
9101:ADC-3680
8972:Receptor
8849:Ketamine
8728:Funapide
8723:DSP-2230
8583:Nabilone
8578:Cannabis
8482:Ampyrone
8254:Tolmetin
8249:Sulindac
8226:Etodolac
8204:Acetates
8175:Isoxicam
8149:Suprofen
8139:Naproxen
8013:+codeine
7948:Tramadol
7943:Tilidine
7923:Propiram
7838:Fentanyl
7818:Dezocine
7767:Thebacon
7739:+aspirin
7682:+aspirin
7580:Laudanum
7565:Morphine
7553:+aspirin
7448:category
7209:(coxibs)
7159:Flunixin
7139:Clonixin
7073:Suprofen
7047:Naproxen
6994:Fenbufen
6918:Isoxicam
6913:Droxicam
6885:Tolmetin
6880:Tiopinac
6875:Sulindac
6840:Isoxepac
6815:Felbinac
6810:Etodolac
6778:Bendazac
6610:Morazone
6595:Kebuzone
6565:Ampyrone
6316:Mitotane
6256:Eribulin
6024:Olaparib
5962:Ixazomib
5638:Thiotepa
5610:Busulfan
5289:Exatecan
5126:Carmofur
4834:assembly
4797: /
4716:16968832
4687:28520369
4681:(NCBI).
4649:16709027
4608:21093404
4600:18230053
4565:12464646
4521:10728691
4490:18485224
4439:17955049
4390:14706335
4349:12618872
4300:12621132
4259:12621133
4218:16943400
4177:22928902
4126:23482349
4118:24215721
4082:32289214
4074:24468642
4039:35885429
4031:24056287
3996:22078590
3988:23178230
3945:34509090
3894:"Brands"
3791:Archived
3758:Archived
3732:Archived
3686:3 August
3680:Archived
3645:Archived
3612:Archived
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3547:Archived
3501:Archived
3454:Archived
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3366:Archived
3330:Archived
3297:Archived
3207:15 April
3201:Archived
3178:11412976
3099:72411967
3091:19236194
3056:19017521
2990:22193214
2941:24063728
2933:17999057
2870:22084715
2816:41772614
2808:17305643
2767:40738580
2759:17176361
2689:11509060
2654:15684203
2613:27959716
2554:Archived
2511:Archived
2482:15713944
2441:28530031
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2365:17719803
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2137:Archived
2098:Archived
2064:Archived
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1994:23726390
1930:Archived
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1873:22141388
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1105:platelet
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221:By mouth
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190:category
172:DailyMed
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11112:NCX-466
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11053:DuP-697
10939:Bucetin
10466:Amfenac
10419:Salicin
10088:TRA-418
9935:AA-2414
9925:12-HETE
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9844:TRA-418
9801:MRE-269
9352:AH-6809
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9151:TM30089
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8706:(e.g.,
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6960:profens
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