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When assembling concatemers from synthetic oligonucleotides, increasing salt concentration to 200 mM was found to be a major optimizing factor due to its ability to enhance ionic strength, which hastened the formation of concatemers.
55:. As an example, if the genes in the phage DNA are arranged ABC, then in a concatemer the genes would be ABCABCABCABC and so on (assuming synthesis was initiated between genes C and A). They are further broken by
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During active infection, some species of viruses have been shown to replicate their genetic material via the formation of concatemers. In the case of
68:, its entire genome is made over and over on a single strand. These long concatemers are subsequently cleaved between the pac-1 and pac-2 regions by
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Bernstein H, Bernstein C (July 1973). "Circular and branched circular concatenates as possible intermediates in bacteriophage T4 DNA replication".
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Oxford
Dictionary of Biochemistry and Molecular Biology, 2nd ed. R. l., eds. Oxford University Press, 2006. p. 138.
117:"Cloning human herpes virus 6A genome into bacterial artificial chromosomes and study of DNA replication intermediates"
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intermediates included circular and branched circular concatemeric structures that likely arose by
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molecule that contains multiple copies of the same DNA sequence linked in series. These
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that occurs once in each copy of the genome). Concatemers are frequently the result of
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260:"Characterization of self-assembled DNA concatemers from synthetic oligonucleotides"
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176:"The molecular biology of human herpesvirus-6 latency and telomere integration"
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when the genome is packaged into individual virions.
264:Computational and Structural Biotechnology Journal
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121:Proceedings of the National Academy of Sciences
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78:replicating DNA was labeled with tritiated
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31:molecules are usually copies of an entire
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115:Borenstein, Ronen; Frenkel, Niza (2009).
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258:Sun, Lu; Åkerman, Björn (August 2014).
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35:linked end to end and separated by
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92:rolling circle replication
49:rolling circle replication
384:Repetitive DNA sequences
174:Arbuckle, Jesse (2011).
142:10.1073/pnas.0908504106
180:Microbes and Infection
23:is a long continuous
16:Type of DNA molecule
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127:(45): 19138–19143.
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21:concatemer
80:thymidine
70:ribozymes
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39:sites (a
29:polymeric
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