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Cold chain

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715: 512: 438: 1660: 91: 534:(GMP) environment that all drugs and biological products are required to follow, and are enforced by the various health regulatory bodies. As such, the distribution process must be validated to ensure that there is no negative impact to the safety, efficacy or quality of the drug substance. The GMP environment requires that all processes that might impact the safety, efficacy or quality of the drug substance must be 523: 1649: 27: 417:), in partnership with Jones, his engineer. Jones designed a portable air-cooling unit for trucks carrying perishable food, for which they obtained a patent on 12 July 1940, subsequent to a challenge to invent a refrigerated truck over a 1937 golf game by associates of Numero's, Werner Transportation Co. president Harry Werner, and United States Air Conditioning Co. president Al Fineberg, 325:
production to consumption. Cold chain management earned its name as a "chain" because it involves linking a set of storage locations and special transport equipment, required for ensuring that temperature conditions for goods are met, while they are in storage or in transit from production to consumption, akin to the interconnected links of a physical chain.
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transport as well as those in transit are important for maintaining the integrity of the chain. The reason why source and destination warehouses need equal importance is because preparing the cold chain packaging for transport is a very important dimension and is as important as conditioning the product itself for transport.
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Yurtseven, C., Ekren, B. Y., & Toy, A. O. (2022). An Overview of Warehouse Operations for Cold Chain. In Industrial Engineering in the Internet-of-Things World: Selected Papers from the Virtual Global Joint Conference on Industrial Engineering and Its Application Areas, GJCIE 2020, August 14–15,
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guidelines for good distribution practices, any comprehensive system of quality assurance must be founded on a reliable system of controlling the quality, safety and efficacy of a finished product delivered to a market. It is imperative that all manufacturing operations are carried out in conformity
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An unbroken cold chain is an uninterrupted sequence of refrigerated production, storage and distribution activities, along with associated equipment and logistics, which maintain a desired low-temperature interval to keep the safety and quality of perishable or sensitive products, such as foods and
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It is important to understand cold chain management as an integrated system of individual components that come together a seamless system for transportation of goods that can maintain the required temperature range during the period the shipment is in the system. Warehouses at both ends of the
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is a set of rules and procedures that ensure the systematic coordination of activities for ensuring temperature-control of goods while in storage and transit. The objective of a cold chain is to preserve the integrity and quality of goods such as pharmaceutical products or perishable good from
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vaccines, and some animal vaccines, such as those for chickens. Next the frozen chain requires -20 degrees C. Varicella and zoster vaccinations require this level. Then the refrigerated chain, which requires temperatures between two and eight degrees C. Most flu vaccinations only require
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and always en-route towards end use or destination, even when held temporarily in cold stores and hence commonly referred to as "cargo" during its entire logistics cycle. Adequate cold storage, in particular, can be crucial to prevent quantitative and qualitative food losses.
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industries and also in some chemical shipments. One common temperature range for a cold chain in pharmaceutical industries is 2 to 8 °C (36 to 46 °F), but the specific temperature (and time at temperature) tolerances depend on the actual product being shipped.
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This technology has been frequently in use since the 1950s, when it was most often used for preserving animal-based cells or tissue. As medical breakthroughs, such as in cancer treatment, have taken place, the demand for cold chain systems has grown. The
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to distant clinics in hot climates served by poorly developed transport networks. Vaccines can lose their efficacy if cold chain management fails. Disruption of a cold chain due to war may produce consequences similar to the
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Protecting Perishable Foods During Transport by Truck and Rail. Supersedes USDA Handbook 669 of 1995. Document HS1328 of the Horticultural Sciences Department, Institute of Food and Agricultural Sciences, University of
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Unique to fresh produce cargoes, the cold chain requires to additionally maintain product specific environment parameters which include air quality levels (carbon dioxide, oxygen, humidity and others).
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need to follow quality assurance as well in order that patients are getting quality medicines. WHO has issued international standards assisting Member States and those involved in the supply chain.
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Brian Lassen, "Is livestock production prepared for an electrically paralysed world?" J. Sci. Food Agric. 2013;93(1):2–4, Explains the vulnerability of the cold chain from electricity dependence.
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tags help monitor the temperature history of the truck, reefer container, warehouse, etc. and the temperature history of the product being shipped. They also can help determine the remaining
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and transportation temperatures as cold as −70 °C (−94 °F), requiring what has been referred to as a "colder chain" infrastructure. This creates some issues of distribution for the
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Riva, Marco; Piergiovanni, Schiraldi, Luciano; Schiraldi, Alberto (January 2001). "Performances of time-temperature indicators in the study of temperature exposure of packaged fresh foods".
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For vaccines, there are different types of cold chains. There is an ultralow, or deep freeze, cold chain for vaccines that require -70 degrees C, such as the Ebola and
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Bishara, R. H. (2006). Cold chain management–an essential component of the global pharmaceutical supply chain. American Pharmaceutical Review, 9(1), 105-109.
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EN 12830:1999 Temperature recorders for the transport, storage and distribution of chilled, frozen and deep-frozen/quick-frozen food and ice cream
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Who, W. H. O. (2010). Good Distribution Practices for Pharmaceutical Products. Technical Report Series. World Health Organization, Annex, 5.
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Pawanexh Kohli, "Fruits and Vegetables Post-Harvest Care: The Basics", Explains why the cold chain is required for fruits and vegetables.
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Regulatory guideless emphasise of strong managerial oversight for the quality systems that ensure integrity of the chain. As per
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with entrepreneur Joseph A. "Joe" Numero. In 1938 Numero sold his Cinema Supplies Inc. movie sound equipment business to
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Departments of Labor, Health and Human Services, and Education, and Related Agencies Appropriations Act, 2008
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Gyesley, S. W. (1991). "Total Systems Approach to Predict Shelf Life of Packaged Foods". ASTM STP 1113-EB.
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The State of Food and Agriculture 2019. Moving forward on food loss and waste reduction, In brief​
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https://www.who.int/docs/default-source/searo/india/publications/immunization-handbook-107-198-part2.pdf
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Brecht, Jeffrey K.; Sargent, Steven A.; Brecht, Patrick E.; Saenz, Jorge; Rodowick, Leonard (2019).
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that states a Knowledge editor's personal feelings or presents an original argument about a topic.
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The State of Food and Agriculture 2019. Moving forward on food loss and waste reduction, In brief
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Pambudi, Nugroho Agung; Sarifudin, Alfan; Gandidi, Indra Mamad; Romadhon, Rahmat (2022).
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was first used in 1908. The first effective cold store in the UK opened in 1882 at
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https://intelsius.com/wp-content/uploads/2011/10/Pharma-Cold-Chain-Bishara_APR.pdf
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Nordic Cold Chain Solutions, Manufacturer of temperature-controlled packaging,
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Refrigeration Nation: A History of Ice, Appliances, and Enterprise in America
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Manual on the Management, Maintenance and Use of Blood Cold Chain Equipment
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Cold chain being maintained using ice box while transporting polio vaccine
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medicines. In other words, the term denotes a low temperature-controlled
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Ray Cowland, Developing ISTA Cold Chain Environmental Standards, 2007.
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https://www.cls.co.at/media/files/who_gdp_tr957_annex5_cls_co_at.pdf
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Black Firsts: 4,000 Ground-Breaking and Pioneering Historical Events
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Biodefense and Pandemic Vaccine and Drug Development Act of 2005
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to form the new entity, U.S. Thermo Control Company (later the
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Rees, Jonathan (2013). "Chapter 1: Inventing the cold chain".
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https://link.springer.com/chapter/10.1007/978-3-030-76724-2_13
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The cold chain distribution process is an extension of the
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personal reflection, personal essay, or argumentative essay
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2020 (pp. 161-175). Springer International Publishing.
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Role of warehousing in integrated cold chain management
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The term 302: 2420:Children's Medical Safety Research Institute 2390:Children's Medical Safety Research Institute 2374: 2209:Advisory Committee on Immunization Practices 2035:National Vaccine Injury Compensation Program 1208:"Cold Chain (And Colder Chain) Distribution" 1167: 1165: 972: 718: This article incorporates text from a 2430:New Jersey Coalition for Vaccination Choice 2395:New Jersey Coalition for Vaccination Choice 1132: 557:. 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Archived from 1150:from the original on 16 February 2017 1053: 1047: 921: 799: 772: 770: 429:, have caused vastly increased need. 337:of products, e.g. fresh agricultural 2513:Australian Vaccination-risks Network 1437: 1283: 1172:Fischetti, Mark (19 November 2020). 1035:from the original on 3 December 2016 957:. Minnesota High Tech Association / 722:work. Licensed under CC BY-SA 3.0 ( 518:used to ship sensitive food products 495:, vaccines being developed may need 20: 2688:Anti-vaccinationism in chiropractic 2425:National Vaccine Information Center 2405:Anti-Vaccination Society of America 2231:Strategic Advisory Group of Experts 2003:Mumps outbreaks in the 21st century 1419:Cold and Chilled Storage Technology 13: 2463: 1736:Oral polio vaccine AIDS hypothesis 1726:Blood-injection-injury type phobia 1705: 1368: 1301:from the original on 24 April 2018 988:. Visible Ink Press. p. 613. 767: 14: 2775: 1014:Addison-Wesley, 1972; pp. 46- 50. 866:Lou Smyrlis (19 September 2013). 808: 541:A cold chain can be managed by a 2683:Alternative vaccination schedule 2474:National Anti-Vaccination League 1853:Democratic Republic of the Congo 1788:2018 Madagascar measles outbreak 1659: 1658: 1647: 1234:Packaging Technology and Science 1054:Kelly, Kate (15 December 2020). 713: 677:Transportation management system 89: 25: 2668:2000 Simpsonwood CDC conference 2400:Informed Consent Action Network 1877:1,000 to 10,000 confirmed cases 1767: 1350: 1338: 1326: 1313: 1260: 1225: 1017: 1002: 2663:Vaccine-induced seropositivity 2523:Informed Medical Options Party 2440:The Autism Community in Action 1212:Science Translational Medicine 1010:Eight Black American Inventors 896: 892:. 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Kennedy Jr. 2236:Immunization Alliance 2180:Dengvaxia controversy 922:Otter, Chris (2020). 662:Thermal decomposition 616:Phase-change material 525: 514: 440: 268:Entamoeba histolytica 176:Clostridium botulinum 2081:Vaccine vial monitor 2065:Operation Warp Speed 584:distribution channel 491:In 2020, during the 478:Spanish–American War 2739:Temperature control 2484:Humanitarian League 1746:Vaccines and autism 1577:Modified atmosphere 1458:nordiccoldchain.com 1184:on 19 December 2020 1100:2022EnRep...8..955P 1012:by Robert C. Hayden 726:). Text taken from 647:Temperature control 425:and its associated 252:Parasitic pathogens 167:Bacterial pathogens 2744:Cooling technology 2622:Yellow Card Scheme 2358:Ethan Lindenberger 2328:Taylor Winterstein 2312:Michael Pichichero 2297:H. 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1046: 1016: 1001: 994: 971: 939: 932: 909: 895: 879: 859: 850:|journal= 827: 798: 766: 755: 740: 739: 737: 734: 710: 707: 705: 704: 699: 694: 689: 684: 679: 674: 669: 664: 659: 654: 649: 644: 639: 634: 629: 624: 618: 613: 608: 603: 597: 595: 592: 566: 563: 508: 505: 501:Pfizer vaccine 464: 461: 455: 452: 447:pharmaceutical 434: 431: 363: 360: 317: 316: 314: 313: 306: 299: 291: 288: 287: 286: 285: 278: 271: 264: 254: 253: 249: 248: 247: 246: 241: 236: 231: 223: 222: 218: 217: 216: 215: 207: 200: 193: 186: 179: 169: 168: 164: 163: 162: 161: 156: 152: 147: 139: 138: 134: 133: 132: 131: 126: 120: 114: 108: 100: 99: 95: 94: 86: 85: 75: 74: 33: 31: 24: 15: 9: 6: 4: 3: 2: 2776: 2765: 2762: 2760: 2757: 2755: 2752: 2750: 2747: 2745: 2742: 2740: 2737: 2735: 2732: 2730: 2727: 2725: 2722: 2721: 2719: 2704: 2701: 2699: 2696: 2694: 2693:CEASE therapy 2691: 2689: 2686: 2684: 2681: 2679: 2676: 2674: 2671: 2669: 2666: 2664: 2661: 2659: 2656: 2654: 2651: 2649: 2646: 2644: 2641: 2640: 2638: 2634: 2628: 2625: 2623: 2620: 2618: 2615: 2613: 2610: 2608: 2605: 2604: 2602: 2600: 2596: 2592: 2582: 2579: 2577: 2574: 2572: 2569: 2568: 2565: 2558: 2548: 2545: 2544: 2541: 2534: 2524: 2521: 2519: 2516: 2514: 2511: 2510: 2507: 2500: 2490: 2487: 2485: 2482: 2480: 2477: 2475: 2472: 2471: 2468: 2461: 2451: 2448: 2446: 2443: 2441: 2438: 2436: 2433: 2431: 2428: 2426: 2423: 2421: 2418: 2416: 2413: 2411: 2408: 2406: 2403: 2401: 2398: 2396: 2393: 2391: 2388: 2386: 2383: 2382: 2379: 2372: 2369: 2365: 2359: 2356: 2354: 2351: 2349: 2346: 2344: 2341: 2339: 2336: 2334: 2331: 2329: 2326: 2325: 2323: 2319: 2313: 2310: 2308: 2305: 2303: 2300: 2298: 2295: 2293: 2290: 2288: 2285: 2283: 2282:Jeffrey Brent 2280: 2278: 2275: 2273: 2270: 2268: 2267:Riko Muranaka 2265: 2263: 2260: 2258: 2255: 2254: 2252: 2248: 2242: 2239: 2237: 2234: 2232: 2229: 2227: 2224: 2222: 2219: 2215: 2212: 2210: 2207: 2206: 2205: 2202: 2201: 2199: 2197:Organizations 2195: 2189: 2187: 2183: 2181: 2178: 2176: 2173: 2172: 2170: 2168:Controversies 2166: 2160: 2159: 2155: 2153: 2152: 2148: 2146: 2143: 2141: 2140: 2136: 2134: 2133: 2129: 2127: 2126: 2122: 2119: 2115: 2114: 2112: 2108: 2102: 2099: 2097: 2094: 2092: 2091:Vaccine trial 2089: 2087: 2084: 2082: 2079: 2078: 2076: 2072: 2066: 2063: 2061: 2058: 2056: 2053: 2051: 2048: 2046: 2043: 2041: 2038: 2036: 2033: 2031: 2028: 2026: 2025: 2021: 2020: 2018: 2014: 2004: 2001: 2000: 1997: 1990: 1978: 1972: 1965: 1961: 1960: 1956: 1954: 1951:, 15 deaths) 1950: 1946: 1943: 1940: 1936: 1933: 1930: 1926: 1923: 1920: 1916: 1913: 1912: 1910: 1906: 1899: 1895: 1892: 1889: 1885: 1882: 1881: 1879: 1875: 1869:, 415 deaths) 1868: 1864: 1861: 1858: 1854: 1851: 1850: 1848: 1844: 1840: 1833: 1828: 1826: 1821: 1819: 1814: 1813: 1810: 1806: 1799: 1789: 1786: 1784: 1781: 1779: 1776: 1775: 1772: 1765: 1762: 1758: 1752: 1749: 1747: 1744: 1742: 1739: 1737: 1734: 1732: 1729: 1727: 1724: 1722: 1719: 1718: 1716: 1714: 1710: 1701: 1696: 1694: 1689: 1687: 1682: 1681: 1678: 1666: 1657: 1655: 1650: 1645: 1644: 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185: 184: 180: 178: 177: 173: 172: 171: 170: 166: 165: 160: 153: 151: 148: 146: 143: 142: 141: 140: 136: 135: 130: 127: 124: 121: 118: 115: 112: 109: 107: 104: 103: 102: 101: 97: 96: 92: 88: 87: 84: 81: 80: 71: 68: 60: 57:February 2024 50: 46: 40: 39: 34:This article 32: 23: 22: 19: 2703:Turbo cancer 2599:surveillance 2595:Epidemiology 2287:Richard Deth 2277:David Baskin 2185: 2156: 2149: 2145:Natural News 2137: 2130: 2123: 2085: 2022: 1963: 1957: 1952: 1948: 1938: 1928: 1918: 1897: 1890:, 83 deaths) 1887: 1866: 1856: 1602:Potjevleesch 1537:Fermentation 1521: 1439: 1418: 1397: 1384:. Retrieved 1378: 1352: 1340: 1328: 1315: 1303:. Retrieved 1294: 1285: 1277:the original 1273:RFID Journal 1272: 1262: 1237: 1233: 1227: 1215:. Retrieved 1211: 1186:. Retrieved 1182:the original 1177: 1152:. Retrieved 1143: 1134: 1091: 1087: 1077: 1065:. Retrieved 1059: 1049: 1037:. Retrieved 1028: 1019: 1009: 1004: 984: 962:. Retrieved 954: 923: 898: 888: 882: 862: 841:cite journal 830: 818:. Retrieved 789:. Retrieved 784: 758: 744: 728: 720:free content 712: 588:supply chain 572: 568: 540: 529: 490: 482: 466: 457: 444: 427:vaccinations 419: 400: 391: 380:reefer ships 365: 331:supply chain 327: 321: 320: 280: 273: 266: 259: 209: 202: 195: 188: 181: 174: 63: 54: 35: 18: 2724:Food safety 2307:Mady Hornig 2262:Neal Halsey 1900:, 2 deaths) 1894:New Zealand 1863:Philippines 1768:Before 2019 1721:Chemophobia 1557:Irradiation 1417:Clive, D., 1240:(1): 1–39. 1217:5 September 1188:20 December 1094:: 955–972. 1067:20 December 964:11 February 791:19 December 785:www.who.int 702:ULT freezer 407:Thermo King 378:began with 343:frozen food 341:, seafood, 282:Trichinella 234:Hepatitis A 229:Enterovirus 211:Cronobacter 83:Food safety 2718:Categories 2617:STEP Study 2302:Boyd Haley 2292:Mark Geier 2257:Paul Offit 2250:Scientists 2086:Cold chain 1522:Cold chain 736:References 642:Shelf life 621:Frank Vale 555:shelf life 516:Slurry ice 507:Validation 392:cold chain 355:perishable 335:shelf life 322:Cold chain 197:Salmonella 2754:Packaging 2734:Logistics 2503:Australia 2175:Pandemrix 2151:Plandemic 1975:Related: 1959:Freewinds 1945:Kuala Koh 1609:Rillettes 1254:108566613 1126:245490703 1118:2352-4847 637:Packaging 536:validated 376:ice trade 374:from the 244:Rotavirus 239:Norovirus 1925:New York 1624:Sugaring 1587:Pickling 1567:Jellying 1547:Freezing 1421:, 1997, 1404:, 2005, 1305:24 April 1299:Archived 1154:24 April 1148:Archived 1039:24 April 1033:Archived 871:Archived 594:See also 474:smallpox 469:vaccines 463:Vaccines 388:iceboxes 190:Listeria 1857:380,766 1619:Smoking 1614:Salting 1592:Potting 1572:Jugging 1562:Jamming 1517:Canning 1380:Florida 1096:Bibcode 820:6 April 709:Sources 611:Dry ice 454:Produce 366:Mobile 362:History 339:produce 275:Giardia 145:FAT TOM 125:(HARPC) 119:(HACCP) 43:Please 2636:Others 2561:Others 2537:France 2186:Lancet 2158:Vaxxed 1993:Others 1867:31,056 1663:  1597:Confit 1532:Drying 1527:Curing 1460:--> 1446:  1425:  1408:  1252:  1124:  1116:  992:  930:  582:. The 2016:Legal 1915:Tonga 1898:2,194 1888:5,700 1884:Samoa 1386:9 May 1250:S2CID 1122:S2CID 814:(PDF) 787:. WHO 781:(PDF) 627:HACCP 370:with 113:(GMP) 98:Terms 2597:and 1802:2019 1444:ISBN 1423:ISBN 1406:ISBN 1388:2023 1307:2018 1219:2020 1190:2020 1156:2018 1114:ISSN 1069:2020 1041:2018 990:ISBN 966:2010 928:ISBN 854:help 822:2009 793:2020 586:and 551:RFID 549:and 433:Uses 382:and 1929:423 1919:612 1242:doi 1104:doi 580:GMP 575:WHO 411:RCA 372:ice 213:spp 2720:: 1949:43 1939:73 1400:, 1293:. 1271:. 1248:. 1238:14 1236:. 1210:. 1198:^ 1176:. 1164:^ 1146:. 1142:. 1120:. 1112:. 1102:. 1090:. 1086:. 1058:. 1031:. 1027:. 974:^ 953:. 942:^ 912:^ 845:: 843:}} 839:{{ 801:^ 783:. 769:^ 545:. 345:, 150:pH 2120:" 2116:" 1966:) 1964:1 1962:( 1947:( 1941:) 1937:( 1931:) 1927:( 1921:) 1917:( 1896:( 1886:( 1865:( 1855:( 1831:e 1824:t 1817:v 1699:e 1692:t 1685:v 1488:e 1481:t 1474:v 1452:. 1390:. 1360:. 1309:. 1256:. 1244:: 1221:. 1192:. 1158:. 1128:. 1106:: 1098:: 1092:8 1071:. 1043:. 998:. 968:. 936:. 906:. 856:) 852:( 824:. 795:. 752:. 386:( 310:e 303:t 296:v 159:) 157:w 70:) 64:( 59:) 55:( 51:.

Index

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Food safety

Foodborne illness
Good manufacturing practice
Hazard analysis and critical control points
Hazard analysis and risk-based preventive controls
Critical control point
FAT TOM
pH
Water activity (aw)
Clostridium botulinum
Escherichia coli
Listeria
Salmonella
Vibrio cholerae
Cronobacter
Enterovirus
Hepatitis A
Norovirus
Rotavirus
Cryptosporidium
Entamoeba histolytica
Giardia
Trichinella
v
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