650:
619:
674:
285:
51:
355:. Unless these supernumeraries are removed they will crowd the adult teeth in what already may be an underdeveloped jaw. If so, the supernumeraries will probably need to be removed to make space for the adult teeth. Up to 13 supernumerary teeth have been observed. Teeth may also be displaced. Cementum formation may be deficient.
692:
Around 5 years of age, surgical correction may be necessary to prevent any worsening of the deformity. If the mother has dysplasia, caesarian delivery may be necessary. Craniofacial surgery may be necessary to correct skull defects. Coxa vara is treated by corrective femoral osteotomies. If there is
721:
fell down a narrow well pipe in her family's Texas property. Ron Short, a roofing contractor who was born without collarbones because of cleidocranial dysostosis and thus could collapse his shoulders to work in cramped corners, arrived at the site and offered to go down the shaft. The rescuers did
649:
210:
often does not close until later, and those affected are often shorter than average. Other symptoms may include a prominent forehead, wide set eyes, abnormal teeth, and a flat nose. Symptoms vary among people; however, intelligence is typically unaffected.
1837:
322:
of the shoulders including ability to touch the shoulders together in front of the chest. The defect is bilateral 80% of the time. Partial collarbones may cause nerve damage symptoms and therefore have to be removed by
1830:
1726:
1711:
618:
1823:
2531:
609:
Diagnosis of CCD spectrum disorder is established in an individual with typical clinical and radiographic findings and/or by the identification of a heterozygous pathogenic variant in RUNX2 (CBFA1).
602:
Different features of the dysostosis are significant. Radiological imaging helps confirm the diagnosis. During gestation (pregnancy), clavicular size can be calculated using available nomograms.
1480:
Nebgen, Denise; Wood, Robert S.; Shapiro, Robert D. (1991). "Management of a mandibular fracture in a patient with cleidocranial dysplasia: Report of a case and review of the literature".
1466:
1679:
2524:
1373:
2517:
264:
It affects about one per million people. Males and females are equally commonly affected. Modern descriptions of the condition date to at least 1896. The term is from
3444:
1588:
474:
3536:
1371:
Saraswathivilasam S. Suresh, A Family With
Cleidocranial Dysplasia And Crossed Ectopic Kidney In One Child, Acta Orthop. Belg. 2009, N° 4 (Vol. 75/4) p.521-527.
673:
261:
such as a device to protect the skull and dental care. Surgery may be performed to fix certain bone abnormalities. Life expectancy is generally normal.
1003:
903:
568:
1815:
1524:
1604:"It was such an honor to attend the CCD Smiles event this past weekend. It was really powerful to be in a room full of other people with CCD..."
311:
3336:
1450:
942:
303:
People with the condition usually present with a painless swelling in the area of the clavicles at 2 to 3 years of age. Common features are:
981:
3541:
2417:
1684:
876:
838:
800:
344:
Bones and joints are underdeveloped. People are shorter and their frames are smaller than their siblings who do not have the condition.
1300:
2509:
2940:
2770:
2699:
2641:
1603:
1377:
3131:
2631:
1910:
314:
part of the bone. In 10% of cases, they are completely missing. If the collarbones are completely missing or reduced to small
2663:
3422:
3103:
3012:
2734:
2715:
2636:
2358:
693:
brachial plexus irritation with pain and numbness, excision of the clavicular fragments can be performed to decompress it.
206:
are typically either poorly developed or absent, which allows the shoulders to be brought close together. The front of the
3089:
1741:
1267:
1580:
2648:
730:
1845:
1410:
1251:
1226:
1198:
1174:
1149:
1121:
1088:
975:
870:
832:
2739:
2658:
2626:
2312:
2031:
3248:
2673:
1637:
3510:
3486:
3117:
17:
995:
3217:
3159:
3145:
2898:
2571:
2147:
1850:
895:
2798:
2719:
2317:
2036:
1866:
1854:
735:
1516:
3274:
2744:
2621:
2348:
2539:
3464:
3448:
3436:
3408:
3317:
3173:
3045:
2959:
2865:
2729:
2402:
2322:
3269:
2724:
2257:
1752:
572:
239:
131:
934:
3031:
2879:
2653:
2294:
1928:
1905:
493:
404:
247:
139:
583:. This results in delayed ossification of midline structures of the body and ensuing defects in
3546:
3440:
3306:
3264:
3212:
2617:
746:
and Abby
Shapiro were born with cleidocranial dysplasia, a trait they share with their mother.
319:
126:
1792:
965:
3312:
2984:
2926:
2912:
2749:
2678:
2197:
1862:
1426:
Machol, Keren; et al. (November 16, 2017). "Cleidocranial
Dysplasia Spectrum Disorder".
860:
822:
701:
Several studies have reported that life expectancy appears to be normal for people with CCD.
251:
143:
792:
3480:
3452:
3331:
3290:
2998:
2884:
2544:
2412:
1292:
470:
1323:"Cleidocranial dysplasia: importance of radiographic images in diagnosis of the condition"
8:
2945:
2230:
1846:
1730:
584:
258:
191:
967:
Inborn Errors of
Development: The Molecular Basis of Clinical Disorders of Morphogenesis
3026:
2823:
2754:
2092:
1735:
1053:
1026:
552:
548:
408:
288:
Female child patient described by Marie and
Sainton, 1898, showing absence of clavicles
230:
gene which is involved in bone formation. Diagnosis is suspected based on symptoms and
223:
75:
551:, but in some cases its cause is not known. The main mechanism is thought to involve
3084:
2804:
2566:
2427:
2407:
1763:
1561:
1497:
1493:
1458:
1451:"Cleidocranial Dysostosis and Syringomyelia Review of the Literature and Case Report"
1431:
1406:
1354:
1247:
1222:
1194:
1170:
1145:
1117:
1084:
1058:
971:
866:
862:
Genetics for
Orthopedic Surgeons: The Molecular Genetic Basis of Orthopedic Disorders
828:
664:
640:
624:
109:
63:
655:
Panoramic view of the jaws showing multiple unerupted supernumerary teeth mimicking
2694:
2540:
2474:
2469:
2390:
2382:
2302:
2266:
2074:
2026:
1983:
1551:
1489:
1344:
1334:
1048:
1038:
68:
3381:
3167:
3078:
2490:
2225:
2055:
2021:
1974:
1757:
1674:
1613:
726:
718:
679:
Poor development of the clavicles and a bell-shaped rib cage in a person with CCD
425:
390:
359:
348:
243:
235:
153:
135:
119:
1581:"Stranger Things' Gaten Matarazzo Discusses Living with Cleidocranial Dysplasia"
1556:
1539:
1321:
Tanaka JL, Ono E, Filho EM, Castilho JC, Moraes LC, Moraes ME (September 2006).
964:
Epstein, Charles J.; Erickson, Robert P.; Wynshaw-Boris, Anthony Joseph (2004).
729:
was born with cleidocranial dysplasia, which is incorporated into his character
2837:
2587:
2353:
2284:
2248:
2220:
2142:
2046:
1920:
1768:
1374:"A family with cleidocranial dysplasia and crossed ectopic kidney in one child"
722:
not end up using him, though McClure was successfully recovered from the well.
591:
478:
1803:
1720:
3530:
3187:
2809:
2363:
2307:
2274:
2157:
1978:
1669:
1642:
743:
528:
500:
466:
439:
379:
331:
297:
1043:
2445:
2338:
2180:
2152:
1938:
1933:
1565:
1435:
1358:
1339:
1322:
1062:
660:
636:
628:
603:
588:
564:
516:
489:
435:
386:
292:
Cleidocranial dysostosis is a general skeletal condition so named from the
1501:
1462:
2368:
2135:
2126:
2011:
1943:
1798:
1787:
532:
504:
352:
327:
3059:
2343:
2279:
2192:
2186:
2162:
2130:
2097:
2066:
2016:
1988:
1349:
632:
580:
576:
520:
512:
373:
338:
293:
203:
81:
1703:
44:
Cleidocranial dysplasia, Marie-Sainton syndrome, mutational dysostosis
3505:
2450:
2395:
2202:
2087:
2080:
2061:
1993:
1957:
1607:
536:
452:
431:
415:
400:
394:
284:
160:
50:
1892:
1888:
1870:
656:
508:
482:
366:
307:
219:
215:
2460:
2118:
337:
A soft spot or larger soft area in the top of the head where the
315:
1746:
1193:. Elsevier Science Health Science Division. 2003. p. 1539.
461:
Decreased bone density, resulting in increased risk of fractures
3300:
3295:
2920:
2906:
2851:
2831:
2668:
1715:
1688:
709:
Cleidocranial dysostosis affects about one per million people.
524:
231:
115:
3416:
3325:
3181:
3153:
3139:
3125:
3111:
3097:
2892:
2859:
1116:. Lippincott Williams & Wilkins. 2005. pp. 251â252.
1027:"Clinical spectrum of cleidocranial dysplasia: a case report"
556:
238:. Other conditions that can produce similar symptoms include
227:
207:
199:
101:
963:
3430:
3402:
3206:
3053:
3039:
3020:
3006:
2992:
2978:
2953:
2934:
2873:
2845:
2817:
2003:
560:
496:
195:
2436:
1966:
1879:
571:), which encodes a transcription factor required for the
485:
1219:
Elsevier's medical terminology for the practicing nurse
941:. National Organization for Rare Disorders, Inc. 2004.
58:
Adult male patient described by Marie and
Sainton, 1898
1320:
1114:
902:. Genetic and Rare Diseases Information Center. 2016.
1540:"Cleidocranial Dysplasia - An Enigma Among Anomalies"
310:(collarbones) can be partly missing leaving only the
1693:
1544:
3445:Ectrodactylyâectodermal dysplasiaâcleft syndrome 3
1612:
1405:. Lippincott Williams & Wilkins. p. 240.
1246:. Lippincott Williams & Wilkins. p. 307.
1479:
27:Birth defect of the collarbones, skull, and teeth
3528:
1638:"Meet new 'Doom Patrol' co-star Abigail Shapiro"
1403:Lovell & Winter's Pediatric Orthopaedics, 6e
1142:Paul and Juhl's essentials of radiologic imaging
1517:"Jessica Makes It to SafetyâAfter 58 1/2 Hours"
1191:Textbook of Radiology and Imaging: Volume 2, 7e
824:Rare Genetic Disorders That Affect the Skeleton
341:failed to close, or the fontanelle closes late.
3537:Congenital disorders of musculoskeletal system
458:High risk of hearing loss caused by infections
3337:Yemenite deaf-blind hypopigmentation syndrome
2525:
1831:
300:deformities which people with it often have.
1455:Clinical Orthopaedics & Related Research
1314:
1024:
1018:
418:, sometimes causing short and wide fingers.
2532:
2518:
1838:
1824:
1216:
929:
927:
925:
923:
921:
890:
888:
886:
787:
785:
783:
781:
779:
49:
1595:
1555:
1482:Journal of Oral and Maxillofacial Surgery
1348:
1338:
1052:
1042:
777:
775:
773:
771:
769:
767:
765:
763:
761:
759:
2941:Posterior polymorphous corneal dystrophy
2771:Autoimmune polyendocrine syndrome type 1
1678:) is being considered for deletion. See
1108:
1106:
1104:
1102:
1100:
970:. Oxford University Press. p. 333.
854:
852:
850:
848:
606:can sometimes be observed in the skull.
283:
84:, prominent forehead, flat nose, shorter
3132:Anterior segment mesenchymal dysgenesis
1629:
1601:
1514:
918:
883:
14:
3529:
1425:
1400:
1241:
1164:
756:
2664:X-linked adrenal hypoplasia congenita
2513:
1819:
1635:
1537:
1396:
1394:
1212:
1210:
1135:
1133:
1097:
1078:
1074:
1072:
858:
845:
279:
226:manner. It is due to a defect in the
2716:Greig cephalopolysyndactyly syndrome
2359:Greig cephalopolysyndactyly syndrome
1578:
1448:
1139:
1006:from the original on 29 October 2016
906:from the original on 28 January 2017
3090:Iridogoniodysgenesis, dominant type
945:from the original on 3 October 2016
803:from the original on 3 October 2016
24:
3374:
1849:malformations and deformations of
1538:Scott, Ronald W. (November 1988).
1515:Kennedy, J. Michael (1987-10-17).
1449:Dore; et al. (January 1987).
1391:
1207:
1144:(7th ed.). Lippincott-Raven.
1130:
1069:
25:
3558:
3542:Transcription factor deficiencies
1682:to help reach a consensus. âș
1661:
1081:Pediatric Orthopedics in Practice
827:. AuthorHouse. 2013. p. 43.
3104:Lymphedemaâdistichiasis syndrome
2700:Trichoârhinoâphalangeal syndrome
2674:Familial partial lipodystrophy 3
1591:from the original on 2016-09-16.
1527:from the original on 2010-06-19.
1469:from the original on 2016-11-03.
1000:UCSF Benioff Children's Hospital
984:from the original on 2016-10-03.
879:from the original on 2016-11-03.
841:from the original on 2017-11-05.
712:
672:
648:
617:
3368:(0) Other transcription factors
2659:Estrogen insensitivity syndrome
2627:Androgen insensitivity syndrome
2032:Congenital patellar dislocation
1911:WallisâZieffâGoldblatt syndrome
1636:Starr, Michael (11 June 2020).
1602:Shapiro, Milly (7 March 2019).
1572:
1531:
1508:
1473:
1442:
1419:
1365:
1303:from the original on 2015-06-26
1285:
1260:
1235:
1183:
1158:
704:
272:from Greek ÎșÏÎ±ÎœÎŻÎż 'skull', and
3249:Hyperimmunoglobulin E syndrome
2654:PHA1AD pseudohypoaldosteronism
1579:Oyla, Gabrielle (2016-09-12).
1457:. January 1987 (214): 229â34.
988:
957:
815:
627:skull radiograph showing open
330:due to hypoplasia of maxilla (
276:'formation of abnormal bone'.
13:
1:
3511:Atrichia with papular lesions
1667:
749:
3218:Popliteal pterygium syndrome
3160:Enlarged vestibular aqueduct
2999:Waardenburg syndrome 1&3
2784:(3) Helix-turn-helix domains
2543:relating to deficiencies of
1494:10.1016/0278-2391(91)90380-5
717:In 1987, a young girl named
696:
687:
597:
563:located on the short arm of
7:
3318:Premature ovarian failure 7
3174:Premature ovarian failure 3
3046:Congenital hypothyroidism 2
2318:Oto-palato-digital syndrome
2313:HallermannâStreiff syndrome
2037:Congenital knee dislocation
1855:musculoskeletal abnormality
1557:10.2519/jospt.1988.10.5.184
1025:Garg RK, Agrawal P (2008).
667:in cleidocranial dysplasia.
542:
10:
3563:
3465:Transcription coregulators
3235:with minor groove contacts
2622:Thyroid hormone resistance
2349:Craniodiaphyseal dysplasia
1293:"Cleidocranial dysostosis"
1268:"Cleidocranial dysostosis"
1217:Vanderwerf, Sally (1998).
996:"Cleidocranial Dysostosis"
372:Open skull sutures, large
3497:
3487:RubinsteinâTaybi syndrome
3472:
3463:
3394:
3367:
3347:
3313:SRY XY gonadal dysgenesis
3283:
3257:
3241:
3232:
3198:
3118:BamforthâLazarus syndrome
3070:
2970:
2790:
2783:
2763:
2730:Duane-radial ray syndrome
2708:
2687:
2679:SF1 XY gonadal dysgenesis
2609:
2600:
2580:
2559:
2552:
2483:
2459:
2435:
2426:
2381:
2331:
2323:Treacher Collins syndrome
2293:
2265:
2256:
2247:
2213:
2174:reduction deficits / limb
2173:
2117:
2110:
2045:
2002:
1965:
1956:
1919:
1887:
1878:
1861:
1778:
1697:
1272:Mount Sinai Health System
1083:. Springer. p. 478.
935:"Cleidocranial Dysplasia"
900:rarediseases.info.nih.gov
896:"Cleidocranial dysplasia"
793:"cleidocranial dysplasia"
559:(also known as Runx2), a
442:have also been described.
365:Bossing (bulging) of the
334:) and other facial bones.
169:
159:
149:
125:
108:
96:
88:
74:
62:
57:
48:
40:
35:
3355:Cleidocranial dysostosis
2572:SaethreâChotzen syndrome
2148:CenaniâLenz syndactylism
1901:Cleidocranial dysostosis
1685:Cleidocranial dysostosis
1680:templates for discussion
1221:. Elsevier. p. 65.
1169:(1st ed.). Masson.
865:. Remedica. p. 92.
742:Sibling actress-singers
421:Vertebral abnormalities.
240:mandibuloacral dysplasia
222:. It is inherited in an
214:The condition is either
194:that mostly affects the
180:Cleidocranial dysostosis
132:Mandibuloacral dysplasia
36:Cleidocranial dysostosis
3332:Waardenburg syndrome 4c
3032:Coloboma of optic nerve
2880:Tooth and nail syndrome
2720:PallisterâHall syndrome
2295:Craniofacial dysostosis
1804:Cleidocranial Dysplasia
1165:Greene, Walter (2006).
1044:10.1186/1757-1626-1-377
555:caused by mutations in
358:Failure of eruption of
248:osteogenesis imperfecta
188:cleidocranial dysplasia
140:osteogenesis imperfecta
3275:Ulnarâmammary syndrome
3233:(4) ÎČ-Scaffold factors
3213:Van der Woude syndrome
2745:TownesâBrocks syndrome
2618:Intracellular receptor
1851:musculoskeletal system
1340:10.2334/josnusd.48.161
859:Young, Ian D. (2002).
475:atlantoaxial impaction
393:, producing a widened
289:
173:One per million people
165:Normal life expectancy
127:Differential diagnosis
114:Based on symptoms and
3449:Limbâmammary syndrome
3437:RappâHodgkin syndrome
3409:PittâHopkins syndrome
2985:Papillorenal syndrome
2960:MowatâWilson syndrome
2866:Nailâpatella syndrome
2750:Acrocallosal syndrome
2403:KlippelâFeil syndrome
1401:Lovell, Wood (2006).
1242:Menkes, John (2006).
1167:Netter's Orthopaedics
1079:Hefti, Fritz (2007).
428:irritation can occur.
287:
252:Hajdu-Cheney syndrome
234:with confirmation by
144:Hajdu-Cheney syndrome
3291:Campomelic dysplasia
3270:LiâFraumeni syndrome
2755:Myotonic dystrophy 2
2725:DenysâDrash syndrome
2545:transcription factor
2413:Spina bifida occulta
1929:Madelung's deformity
1906:Sprengel's deformity
471:basilar invagination
465:Other features are:
455:and knee deformities
403:can occur, limiting
3085:Axenfeld syndrome 3
2899:Axenfeld syndrome 1
2838:SPD1 synpolydactyly
2603:DNA-binding domains
2231:RAPADILINO syndrome
1244:Child Neurology, 7e
1140:Juhl, John (1998).
663:and underdeveloped
639:and underdeveloped
424:On rare occasions,
414:Short middle fifth
353:supernumerary teeth
259:supportive measures
257:Treatment includes
218:or occurs as a new
3441:HayâWells syndrome
3265:HoltâOram syndrome
3027:Gillespie syndrome
2946:Fuchs' dystrophy 3
2824:Currarino syndrome
2093:Rocker bottom foot
1779:External resources
731:Dustin Henderson's
553:haploinsufficiency
549:autosomal dominant
527:, short / absent
507:, small and high
451:Increased risk of
409:Trendelenburg gait
290:
280:Signs and symptoms
224:autosomal dominant
3524:
3523:
3520:
3519:
3390:
3389:
3363:
3362:
3228:
3227:
2805:Ohtahara syndrome
2779:
2778:
2649:Kennedy's disease
2596:
2595:
2567:Feingold syndrome
2553:(1) Basic domains
2541:Genetic disorders
2507:
2506:
2503:
2502:
2499:
2498:
2428:Thoracic skeleton
2408:Spondylolisthesis
2377:
2376:
2243:
2242:
2239:
2238:
2106:
2105:
1952:
1951:
1813:
1812:
1521:Los Angeles Times
665:maxillary sinuses
641:paranasal sinuses
523:, short / absent
519:, absence of the
445:Wide nasal bridge
389:of bones forming
177:
176:
110:Diagnostic method
30:Medical condition
16:(Redirected from
3554:
3470:
3469:
3372:
3371:
3239:
3238:
2810:Lissencephaly X2
2788:
2787:
2695:Barakat syndrome
2607:
2606:
2557:
2556:
2534:
2527:
2520:
2511:
2510:
2475:Pectus carinatum
2470:Pectus excavatum
2433:
2432:
2391:Spinal curvature
2383:Vertebral column
2303:Crouzon syndrome
2267:Craniosynostosis
2263:
2262:
2254:
2253:
2119:fingers and toes
2115:
2114:
2027:Discoid meniscus
1984:Upington disease
1963:
1962:
1885:
1884:
1876:
1875:
1840:
1833:
1826:
1817:
1816:
1695:
1694:
1655:
1654:
1652:
1650:
1633:
1627:
1626:
1624:
1622:
1616:
1611:. Archived from
1599:
1593:
1592:
1576:
1570:
1569:
1559:
1535:
1529:
1528:
1512:
1506:
1505:
1477:
1471:
1470:
1446:
1440:
1439:
1423:
1417:
1416:
1398:
1389:
1388:
1386:
1385:
1376:. Archived from
1369:
1363:
1362:
1352:
1342:
1318:
1312:
1311:
1309:
1308:
1289:
1283:
1282:
1280:
1278:
1264:
1258:
1257:
1239:
1233:
1232:
1214:
1205:
1204:
1187:
1181:
1180:
1162:
1156:
1155:
1137:
1128:
1127:
1110:
1095:
1094:
1076:
1067:
1066:
1056:
1046:
1022:
1016:
1015:
1013:
1011:
992:
986:
985:
961:
955:
954:
952:
950:
939:rarediseases.org
931:
916:
915:
913:
911:
892:
881:
880:
856:
843:
842:
819:
813:
812:
810:
808:
799:. January 2008.
789:
676:
652:
621:
488:structures with
326:The mandible is
92:Present at birth
69:Medical genetics
53:
33:
32:
21:
3562:
3561:
3557:
3556:
3555:
3553:
3552:
3551:
3527:
3526:
3525:
3516:
3493:
3459:
3386:
3382:Kabuki syndrome
3359:
3343:
3279:
3253:
3234:
3224:
3194:
3066:
2966:
2775:
2759:
2704:
2683:
2602:
2601:(2) Zinc finger
2592:
2576:
2548:
2547:or coregulators
2538:
2508:
2495:
2491:Poland syndrome
2479:
2455:
2422:
2373:
2327:
2289:
2235:
2226:Larsen syndrome
2214:multiple joints
2209:
2169:
2102:
2041:
2022:Genu recurvatum
1998:
1975:Hip dislocation
1948:
1915:
1865:
1857:
1844:
1814:
1809:
1808:
1774:
1773:
1706:
1683:
1664:
1659:
1658:
1648:
1646:
1634:
1630:
1620:
1618:
1600:
1596:
1577:
1573:
1536:
1532:
1513:
1509:
1478:
1474:
1447:
1443:
1424:
1420:
1413:
1399:
1392:
1383:
1381:
1372:
1370:
1366:
1319:
1315:
1306:
1304:
1297:Radiopaedia.org
1291:
1290:
1286:
1276:
1274:
1266:
1265:
1261:
1254:
1240:
1236:
1229:
1215:
1208:
1201:
1189:
1188:
1184:
1177:
1163:
1159:
1152:
1138:
1131:
1124:
1112:
1111:
1098:
1091:
1077:
1070:
1023:
1019:
1009:
1007:
994:
993:
989:
978:
962:
958:
948:
946:
933:
932:
919:
909:
907:
894:
893:
884:
873:
857:
846:
835:
821:
820:
816:
806:
804:
797:GHR.nlm.nih.gov
791:
790:
757:
752:
736:Stranger Things
727:Gaten Matarazzo
719:Jessica McClure
715:
707:
699:
690:
685:
684:
683:
680:
677:
668:
653:
644:
622:
600:
573:differentiation
547:CCD is usually
545:
426:brachial plexus
391:symphysis pubis
360:permanent teeth
349:permanent teeth
282:
244:pyknodysostosis
236:genetic testing
186:), also called
154:Supportive care
136:pyknodysostosis
120:genetic testing
118:, confirmed by
31:
28:
23:
22:
15:
12:
11:
5:
3560:
3550:
3549:
3544:
3539:
3522:
3521:
3518:
3517:
3515:
3514:
3501:
3499:
3495:
3494:
3492:
3491:
3490:
3489:
3476:
3474:
3467:
3461:
3460:
3458:
3457:
3456:
3455:
3427:
3426:
3425:
3413:
3412:
3411:
3398:
3396:
3392:
3391:
3388:
3387:
3385:
3384:
3378:
3376:
3369:
3365:
3364:
3361:
3360:
3358:
3357:
3351:
3349:
3345:
3344:
3342:
3341:
3340:
3339:
3334:
3322:
3321:
3320:
3315:
3303:
3298:
3293:
3287:
3285:
3281:
3280:
3278:
3277:
3272:
3267:
3261:
3259:
3255:
3254:
3252:
3251:
3245:
3243:
3236:
3230:
3229:
3226:
3225:
3223:
3222:
3221:
3220:
3215:
3202:
3200:
3196:
3195:
3193:
3192:
3191:
3190:
3178:
3177:
3176:
3164:
3163:
3162:
3150:
3149:
3148:
3136:
3135:
3134:
3122:
3121:
3120:
3108:
3107:
3106:
3094:
3093:
3092:
3087:
3074:
3072:
3068:
3067:
3065:
3064:
3063:
3062:
3050:
3049:
3048:
3036:
3035:
3034:
3029:
3017:
3016:
3015:
3003:
3002:
3001:
2989:
2988:
2987:
2974:
2972:
2968:
2967:
2965:
2964:
2963:
2962:
2950:
2949:
2948:
2943:
2931:
2930:
2929:
2917:
2916:
2915:
2903:
2902:
2901:
2889:
2888:
2887:
2882:
2870:
2869:
2868:
2856:
2855:
2854:
2842:
2841:
2840:
2828:
2827:
2826:
2814:
2813:
2812:
2807:
2794:
2792:
2785:
2781:
2780:
2777:
2776:
2774:
2773:
2767:
2765:
2761:
2760:
2758:
2757:
2752:
2747:
2742:
2737:
2732:
2727:
2722:
2712:
2710:
2706:
2705:
2703:
2702:
2697:
2691:
2689:
2685:
2684:
2682:
2681:
2676:
2671:
2666:
2661:
2656:
2651:
2646:
2645:
2644:
2639:
2634:
2624:
2613:
2611:
2604:
2598:
2597:
2594:
2593:
2591:
2590:
2588:Tietz syndrome
2584:
2582:
2578:
2577:
2575:
2574:
2569:
2563:
2561:
2554:
2550:
2549:
2537:
2536:
2529:
2522:
2514:
2505:
2504:
2501:
2500:
2497:
2496:
2494:
2493:
2487:
2485:
2481:
2480:
2478:
2477:
2472:
2466:
2464:
2457:
2456:
2454:
2453:
2448:
2442:
2440:
2430:
2424:
2423:
2421:
2420:
2415:
2410:
2405:
2400:
2399:
2398:
2387:
2385:
2379:
2378:
2375:
2374:
2372:
2371:
2366:
2361:
2356:
2354:Dolichocephaly
2351:
2346:
2341:
2335:
2333:
2329:
2328:
2326:
2325:
2320:
2315:
2310:
2305:
2299:
2297:
2291:
2290:
2288:
2287:
2285:Trigonocephaly
2282:
2277:
2271:
2269:
2260:
2258:Skull and face
2251:
2245:
2244:
2241:
2240:
2237:
2236:
2234:
2233:
2228:
2223:
2221:Arthrogryposis
2217:
2215:
2211:
2210:
2208:
2207:
2206:
2205:
2200:
2195:
2183:
2177:
2175:
2171:
2170:
2168:
2167:
2166:
2165:
2155:
2150:
2145:
2143:Arachnodactyly
2140:
2139:
2138:
2123:
2121:
2112:
2108:
2107:
2104:
2103:
2101:
2100:
2095:
2090:
2085:
2084:
2083:
2071:
2070:
2069:
2064:
2051:
2049:
2047:foot deformity
2043:
2042:
2040:
2039:
2034:
2029:
2024:
2019:
2014:
2008:
2006:
2000:
1999:
1997:
1996:
1991:
1986:
1981:
1971:
1969:
1960:
1954:
1953:
1950:
1949:
1947:
1946:
1941:
1936:
1931:
1925:
1923:
1921:hand deformity
1917:
1916:
1914:
1913:
1908:
1903:
1897:
1895:
1882:
1873:
1859:
1858:
1843:
1842:
1835:
1828:
1820:
1811:
1810:
1807:
1806:
1795:
1783:
1782:
1780:
1776:
1775:
1772:
1771:
1760:
1749:
1738:
1723:
1707:
1702:
1701:
1699:
1698:Classification
1692:
1691:
1663:
1662:External links
1660:
1657:
1656:
1628:
1594:
1571:
1550:(5): 184â188.
1530:
1507:
1488:(4): 405â409.
1472:
1441:
1418:
1411:
1390:
1364:
1313:
1284:
1259:
1252:
1234:
1227:
1206:
1199:
1182:
1175:
1157:
1150:
1129:
1122:
1096:
1089:
1068:
1017:
987:
976:
956:
917:
882:
871:
844:
833:
814:
754:
753:
751:
748:
714:
711:
706:
703:
698:
695:
689:
686:
682:
681:
678:
671:
669:
654:
647:
645:
623:
616:
613:
612:
611:
599:
596:
592:bone formation
544:
541:
479:metopic suture
477:), persistent
463:
462:
459:
456:
449:
446:
443:
429:
422:
419:
412:
398:
383:
377:
370:
363:
356:
345:
342:
335:
324:
318:, this allows
296:(cleido-) and
281:
278:
268:'collarbone',
175:
174:
171:
167:
166:
163:
157:
156:
151:
147:
146:
129:
123:
122:
112:
106:
105:
98:
94:
93:
90:
86:
85:
78:
72:
71:
66:
60:
59:
55:
54:
46:
45:
42:
38:
37:
29:
26:
9:
6:
4:
3:
2:
3559:
3548:
3547:Rare diseases
3545:
3543:
3540:
3538:
3535:
3534:
3532:
3512:
3508:
3507:
3503:
3502:
3500:
3496:
3488:
3485:
3484:
3483:
3482:
3478:
3477:
3475:
3471:
3468:
3466:
3462:
3454:
3450:
3446:
3442:
3438:
3435:
3434:
3433:
3432:
3428:
3424:
3421:
3420:
3419:
3418:
3414:
3410:
3407:
3406:
3405:
3404:
3400:
3399:
3397:
3393:
3383:
3380:
3379:
3377:
3373:
3370:
3366:
3356:
3353:
3352:
3350:
3346:
3338:
3335:
3333:
3330:
3329:
3328:
3327:
3323:
3319:
3316:
3314:
3311:
3310:
3309:
3308:
3304:
3302:
3299:
3297:
3294:
3292:
3289:
3288:
3286:
3282:
3276:
3273:
3271:
3268:
3266:
3263:
3262:
3260:
3256:
3250:
3247:
3246:
3244:
3240:
3237:
3231:
3219:
3216:
3214:
3211:
3210:
3209:
3208:
3204:
3203:
3201:
3197:
3189:
3186:
3185:
3184:
3183:
3179:
3175:
3172:
3171:
3170:
3169:
3165:
3161:
3158:
3157:
3156:
3155:
3151:
3147:
3144:
3143:
3142:
3141:
3137:
3133:
3130:
3129:
3128:
3127:
3123:
3119:
3116:
3115:
3114:
3113:
3109:
3105:
3102:
3101:
3100:
3099:
3095:
3091:
3088:
3086:
3083:
3082:
3081:
3080:
3076:
3075:
3073:
3069:
3061:
3058:
3057:
3056:
3055:
3051:
3047:
3044:
3043:
3042:
3041:
3037:
3033:
3030:
3028:
3025:
3024:
3023:
3022:
3018:
3014:
3011:
3010:
3009:
3008:
3004:
3000:
2997:
2996:
2995:
2994:
2990:
2986:
2983:
2982:
2981:
2980:
2976:
2975:
2973:
2969:
2961:
2958:
2957:
2956:
2955:
2951:
2947:
2944:
2942:
2939:
2938:
2937:
2936:
2932:
2928:
2925:
2924:
2923:
2922:
2918:
2914:
2911:
2910:
2909:
2908:
2904:
2900:
2897:
2896:
2895:
2894:
2890:
2886:
2883:
2881:
2878:
2877:
2876:
2875:
2871:
2867:
2864:
2863:
2862:
2861:
2857:
2853:
2850:
2849:
2848:
2847:
2843:
2839:
2836:
2835:
2834:
2833:
2829:
2825:
2822:
2821:
2820:
2819:
2815:
2811:
2808:
2806:
2803:
2802:
2801:
2800:
2796:
2795:
2793:
2789:
2786:
2782:
2772:
2769:
2768:
2766:
2762:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2726:
2723:
2721:
2717:
2714:
2713:
2711:
2707:
2701:
2698:
2696:
2693:
2692:
2690:
2686:
2680:
2677:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2647:
2643:
2640:
2638:
2635:
2633:
2630:
2629:
2628:
2625:
2623:
2619:
2615:
2614:
2612:
2608:
2605:
2599:
2589:
2586:
2585:
2583:
2579:
2573:
2570:
2568:
2565:
2564:
2562:
2558:
2555:
2551:
2546:
2542:
2535:
2530:
2528:
2523:
2521:
2516:
2515:
2512:
2492:
2489:
2488:
2486:
2482:
2476:
2473:
2471:
2468:
2467:
2465:
2462:
2458:
2452:
2449:
2447:
2444:
2443:
2441:
2438:
2434:
2431:
2429:
2425:
2419:
2418:Sacralization
2416:
2414:
2411:
2409:
2406:
2404:
2401:
2397:
2394:
2393:
2392:
2389:
2388:
2386:
2384:
2380:
2370:
2367:
2365:
2364:Plagiocephaly
2362:
2360:
2357:
2355:
2352:
2350:
2347:
2345:
2342:
2340:
2337:
2336:
2334:
2330:
2324:
2321:
2319:
2316:
2314:
2311:
2309:
2308:Hypertelorism
2306:
2304:
2301:
2300:
2298:
2296:
2292:
2286:
2283:
2281:
2278:
2276:
2275:Scaphocephaly
2273:
2272:
2270:
2268:
2264:
2261:
2259:
2255:
2252:
2250:
2246:
2232:
2229:
2227:
2224:
2222:
2219:
2218:
2216:
2212:
2204:
2201:
2199:
2196:
2194:
2191:
2190:
2189:
2188:
2184:
2182:
2179:
2178:
2176:
2172:
2164:
2161:
2160:
2159:
2158:Brachydactyly
2156:
2154:
2151:
2149:
2146:
2144:
2141:
2137:
2134:
2133:
2132:
2128:
2125:
2124:
2122:
2120:
2116:
2113:
2111:Either / both
2109:
2099:
2096:
2094:
2091:
2089:
2086:
2082:
2079:
2078:
2077:
2076:
2072:
2068:
2065:
2063:
2060:
2059:
2058:
2057:
2053:
2052:
2050:
2048:
2044:
2038:
2035:
2033:
2030:
2028:
2025:
2023:
2020:
2018:
2015:
2013:
2010:
2009:
2007:
2005:
2001:
1995:
1992:
1990:
1987:
1985:
1982:
1980:
1979:Hip dysplasia
1976:
1973:
1972:
1970:
1968:
1964:
1961:
1959:
1955:
1945:
1942:
1940:
1937:
1935:
1932:
1930:
1927:
1926:
1924:
1922:
1918:
1912:
1909:
1907:
1904:
1902:
1899:
1898:
1896:
1894:
1890:
1886:
1883:
1881:
1877:
1874:
1872:
1868:
1864:
1860:
1856:
1852:
1848:
1841:
1836:
1834:
1829:
1827:
1822:
1821:
1818:
1805:
1801:
1800:
1796:
1794:
1790:
1789:
1785:
1784:
1781:
1777:
1770:
1766:
1765:
1761:
1759:
1755:
1754:
1750:
1748:
1744:
1743:
1739:
1737:
1733:
1732:
1728:
1724:
1722:
1718:
1717:
1713:
1709:
1708:
1705:
1700:
1696:
1690:
1686:
1681:
1677:
1676:
1671:
1666:
1665:
1645:
1644:
1643:New York Post
1639:
1632:
1617:on 2021-12-23
1615:
1610:
1609:
1605:
1598:
1590:
1586:
1582:
1575:
1567:
1563:
1558:
1553:
1549:
1545:
1541:
1534:
1526:
1522:
1518:
1511:
1503:
1499:
1495:
1491:
1487:
1483:
1476:
1468:
1464:
1460:
1456:
1452:
1445:
1437:
1433:
1429:
1422:
1414:
1412:9780781753586
1408:
1404:
1397:
1395:
1380:on 2015-06-26
1379:
1375:
1368:
1360:
1356:
1351:
1346:
1341:
1336:
1332:
1328:
1324:
1317:
1302:
1298:
1294:
1288:
1273:
1269:
1263:
1255:
1253:9780781751049
1249:
1245:
1238:
1230:
1228:9780444824707
1224:
1220:
1213:
1211:
1202:
1200:9780443071096
1196:
1192:
1186:
1178:
1176:9781929007028
1172:
1168:
1161:
1153:
1151:9780397584215
1147:
1143:
1136:
1134:
1125:
1123:9780781742986
1119:
1115:
1109:
1107:
1105:
1103:
1101:
1092:
1090:9783540699644
1086:
1082:
1075:
1073:
1064:
1060:
1055:
1050:
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713:Notable cases
710:
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675:
670:
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662:
661:gonial angles
658:
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638:
637:wormian bones
634:
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629:skull sutures
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525:fibular bones
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501:hemivertebrae
498:
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494:supernumerary
491:
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448:Crooked teeth
447:
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440:syringomyelia
437:
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380:Hypertelorism
378:
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18:Cleidocranial
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3498:Corepressor:
3479:
3473:Coactivator:
3429:
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3354:
3324:
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2952:
2933:
2919:
2905:
2891:
2872:
2858:
2844:
2830:
2816:
2797:
2339:Macrocephaly
2185:
2181:Acheiropodia
2153:Ectrodactyly
2073:
2054:
1939:Oligodactyly
1934:Clinodactyly
1900:
1863:Appendicular
1797:
1786:
1762:
1751:
1740:
1725:
1710:
1673:
1647:. Retrieved
1641:
1631:
1619:. Retrieved
1614:the original
1606:
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1520:
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1382:. Retrieved
1378:the original
1367:
1333:(3): 161â6.
1330:
1326:
1316:
1305:. Retrieved
1296:
1287:
1275:. Retrieved
1271:
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1034:
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1008:. Retrieved
999:
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966:
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947:. Retrieved
938:
908:. Retrieved
899:
861:
823:
817:
805:. Retrieved
796:
741:
734:
724:
716:
708:
705:Epidemiology
700:
691:
608:
601:
589:endochondral
565:chromosome 6
546:
529:radial bones
517:illiac bones
490:hearing loss
464:
436:spina bifida
407:and causing
387:ossification
302:
291:
273:
269:
265:
263:
256:
213:
192:birth defect
187:
183:
179:
178:
2369:Saddle nose
2136:Webbed toes
2127:Polydactyly
2012:Genu valgum
1944:Polydactyly
1799:GeneReviews
1788:MedlinePlus
1668:âč The
1428:GeneReviews
1350:11449/69073
635:, multiple
633:fontanelles
581:osteoblasts
533:hypoplastic
505:spondylosis
374:fontanelles
204:collarbones
89:Usual onset
41:Other names
3531:Categories
2344:Platybasia
2280:Oxycephaly
2193:Phocomelia
2187:Ectromelia
2163:Stub thumb
2131:Syndactyly
2098:Hammer toe
2067:Pigeon toe
2017:Genu varum
1989:Coxa valga
1847:Congenital
1764:DiseasesDB
1585:People.com
1384:2015-06-26
1327:J Oral Sci
1307:2015-06-26
1277:30 January
1037:(1): 377.
910:29 October
750:References
659:, missing
585:membranous
577:stem cells
521:pubic bone
513:hypoplasia
339:fontanelle
328:prognathic
294:collarbone
274:dysostosis
82:collarbone
3395:Ungrouped
2396:Scoliosis
2203:Hemimelia
2088:Pes cavus
2081:Flat feet
2062:Club foot
1994:Coxa vara
1608:Instagram
1010:2 October
949:2 October
807:2 October
697:Prognosis
688:Treatment
598:Diagnosis
537:phalanges
535:terminal
469:bossing,
453:flat foot
432:Scoliosis
416:phalanges
405:abduction
401:Coxa vara
395:symphysis
308:Clavicles
216:inherited
170:Frequency
161:Prognosis
150:Treatment
100:Genetic (
64:Specialty
2446:Cervical
1893:shoulder
1889:clavicle
1871:dysmelia
1670:template
1589:Archived
1566:18796963
1525:Archived
1467:Archived
1436:20301686
1359:17023750
1301:Archived
1063:19063717
1004:Archived
982:Archived
943:Archived
904:Archived
877:Archived
839:Archived
801:Archived
657:premolar
631:, large
543:Genetics
509:scapulae
483:abnormal
467:parietal
385:Delayed
367:forehead
351:include
323:surgery.
316:vestiges
220:mutation
80:Missing
76:Symptoms
3146:ACD/MPV
2461:sternum
1758:D002973
1672:below (
1649:15 June
1621:15 June
1502:2005496
1463:3791747
1054:2614945
1031:Cases J
625:Lateral
298:cranium
270:cranial
190:, is a
3481:CREBBP
3301:MODY 5
3296:MODY 3
3060:STHAG3
3013:MODY 9
2921:POU3F4
2913:DFNA15
2907:POU4F3
2852:MODY 4
2832:HOXD13
2740:MRX 89
2735:MODY 7
2669:MODY 1
2484:other:
2198:Amelia
2075:valgus
1793:001589
1747:119600
1736:755.59
1689:Curlie
1675:Curlie
1564:
1500:
1461:
1434:
1409:
1357:
1250:
1225:
1197:
1173:
1148:
1120:
1087:
1061:
1051:
974:
869:
831:
725:Actor
312:medial
266:cleido
250:, and
232:X-rays
202:. The
116:X-rays
97:Causes
3423:TNDM1
3417:ZFP57
3326:SOX10
3182:FOXP3
3168:FOXL2
3154:FOXI1
3140:FOXF1
3126:FOXE3
3112:FOXE1
3098:FOXC2
3079:FOXC1
2927:DFNX2
2893:PITX2
2860:LMX1B
2451:Bifid
2332:other
2249:Axial
2056:varus
1769:30594
1721:Q74.0
744:Milly
579:into
557:CBFA1
503:with
228:RUNX2
208:skull
200:teeth
196:bones
104:gene)
102:RUNX2
3453:OFC8
3431:TP63
3403:TCF4
3348:4.11
3207:IRF6
3188:IPEX
3054:PAX9
3040:PAX8
3021:PAX6
3007:PAX4
2993:PAX3
2979:PAX2
2954:ZEB2
2935:ZEB1
2885:OFC5
2874:MSX1
2846:PDX1
2818:MNX1
2642:CAIS
2637:MAIS
2632:PAIS
2437:ribs
2004:knee
1880:Arms
1867:limb
1753:MeSH
1742:OMIM
1731:9-CM
1651:2020
1623:2020
1562:PMID
1498:PMID
1459:PMID
1432:PMID
1407:ISBN
1355:PMID
1279:2023
1248:ISBN
1223:ISBN
1195:ISBN
1171:ISBN
1146:ISBN
1118:ISBN
1085:ISBN
1059:PMID
1012:2016
972:ISBN
951:2016
912:2017
867:ISBN
829:ISBN
809:2016
587:and
569:6p21
561:gene
497:ribs
438:and
347:The
198:and
3375:0.6
3307:SF1
3284:4.7
3258:4.3
3242:4.2
3199:3.5
3071:3.3
2971:3.2
2799:ARX
2791:3.1
2764:2.5
2709:2.3
2688:2.2
2620:):
2610:2.1
2581:1.3
2560:1.2
1967:hip
1958:Leg
1727:ICD
1712:ICD
1687:at
1552:doi
1490:doi
1345:hdl
1335:doi
1049:PMC
1039:doi
575:of
515:of
486:ear
184:CCD
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3506:HR
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