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Receptor-mediated endocytosis

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for degradation. However, receptor-mediated endocytosis is also actively implicated in transducing signals from the cell periphery to the nucleus. This became apparent when it was found that the association and formation of specific signaling complexes via clathrin-mediated endocytosis is required
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to the plasma membrane around where invagination will take place. Invagination of the plasma membrane then occurs, forming a clathrin-coated pit. Other receptors can nucleate a clathrin-coated pit allowing formation around the receptor. A mature pit will be cleaved from the plasma membrane through
260:). The role of receptor-mediated endocytosis is well recognized up take downregulation of transmembrane signal transduction but can also promote sustained signal transduction. The activated receptor becomes internalised and is transported to late endosomes and 207:-mediated endocytosis remains the best studied. Clathrin-mediated endocytosis of many receptor types begins with the ligands binding to receptors on the cell plasma membrane. The ligand and receptor will then recruit adaptor proteins and clathrin 281:
Using fluorescent or EM visible dyes to tag specific molecules in living cells, it is possible to follow the internalization of cargo molecules and the evolution of a clathrin-coated pit by fluorescence microscopy and immuno electron microscopy.
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Nevola L, MartĂ­n-QuirĂłs A, Eckelt K, Camarero N, Tosi S, Llobet A, et al. (July 2013). "Light-regulated stapled peptides to inhibit protein-protein interactions involved in clathrin-mediated endocytosis".
269:). Additionally it has been proposed that the directed transport of active signaling complexes to the nucleus might be required to enable signaling, due to the fact that random 273:
is too slow, and mechanisms permanently downregulating incoming signals are strong enough to shut down signaling completely without additional signal-transducing mechanisms.
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Prischich D, del Dedo JE, Cambra M, Prat J, Camarero N, Nevola L, et al. (April 2021). "Light-dependent inhibition of clathrin-mediated endocytosis in yeast".
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The function of receptor-mediated endocytosis is diverse. It is widely used for the specific uptake of certain substances required by the cell (examples include
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Glass JJ, Yuen D, Rae J, Johnston AP, Parton RG, Kent SJ, De Rose R (April 2016). "Human immune cell targeting of protein nanoparticles--caveospheres".
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Since the process is non-specific, the ligand can be a carrier for larger molecules. If the target cell has a known specific
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Camarero N, Trapero A, PĂ©rez-JimĂ©nez A, Macia E, Gomila-Juaneda A, MartĂ­n-QuirĂłs A, et al. (September 2020).
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on the surface of the cell. Only the receptor-specific substances can enter the cell through this process.
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Sorkin A, Puthenveedu MA (2013-01-01). "Clathrin-Mediated Endocytosis". In Yarden Y, Tarcic G (eds.).
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Endocytosis is triggered when a specific receptor is activated in receptor-mediated endocytosis.
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Thomsen AR, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, et al. (August 2016).
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can be used to target the nanoparticles to specific receptors on the cell surface (such as
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MartĂ­n-QuirĂłs A, Nevola L, Eckelt K, Madurga S, Gorostiza P, Giralt E (January 2015).
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The initiation of vesicle formation can be delayed/inhibited by temperature variations
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Proceedings of the National Academy of Sciences of the United States of America
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Kaksonen M, Roux A (May 2018). "Mechanisms of clathrin-mediated endocytosis".
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compounds allow spatiotemporal control of the endocytosis with light.
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that then uncoats of clathrin and typically fuses to a sorting
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containing the absorbed substances and is strictly mediated by
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The formation of these vesicles is sensitive to inhibition by
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can be brought into the cell through a few mechanisms (e.g.
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the use of membrane-binding and fission proteins such as
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Induction within minutes of exposure to excess ligand.
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Springer New York. pp. 1–31. 405: 403: 373:Non-specific, adsorptive pinocytosis 58:adding citations to reliable sources 29: 592:The Journal of Experimental Biology 330:(Dynazos) has been reported. These 24: 337: 25: 2186: 932: 400: 34: 879: 848: 807: 627:Kirchhausen T (November 2009). 167:– by the inward budding of the 69:"Receptor-mediated endocytosis" 45:needs additional citations for 833:10.1016/j.chembiol.2014.10.022 771: 728: 669: 620: 579: 528: 436: 295:To achieve internalisation of 276: 13: 1: 1117:Receptor-mediated endocytosis 412:Vesicle Trafficking in Cancer 393: 324:clathrin-mediated endocytosis 191:Although receptors and their 149:clathrin-mediated endocytosis 141:Receptor-mediated endocytosis 18:Clathrin-mediated endocytosis 1186:vesicular transport proteins 320:protein-protein interactions 7: 586:Kholodenko BN (June 2003). 420:10.1007/978-1-4614-6528-7_1 356: 235: 10: 2191: 1065:Secondary active transport 504:10.1016/j.cell.2016.07.004 186: 2149: 2080: 2045: 2020: 1999: 1973: 1949: 1936: 1923: 1891:Adaptor protein complex 4 1889: 1842:Adaptor protein complex 3 1840: 1803:Adaptor protein complex 2 1801: 1744:Adaptor protein complex 1 1742: 1735: 1728: 1695: 1663: 1614: 1538: 1501: 1403: 1363: 1215: 1206: 1197: 1130: 1082: 1073: 1035: 992: 982: 865:10.1101/2021.04.01.432428 645:10.1016/j.tcb.2009.09.002 2121:Vacuolar protein sorting 1060:Primary active transport 535:Howe CL (October 2005). 820:Chemistry & Biology 703:10.1073/pnas.1315202110 316:photoswitchable peptide 222:clathrin-coated vesicle 793:10.1002/anie.201303324 633:Trends in Cell Biology 554:10.1186/1742-4682-2-43 245: 175:). This process forms 137: 1012:Facilitated diffusion 859:: 2021.04.01.432428. 243: 220:proteins), forming a 135: 986:biological membranes 598:(Pt 12): 2073–2082. 457:10.1038/nrm.2017.132 332:photopharmacological 299:into cells, such as 163:– and in some cases 54:improve this article 749:2016Nanos...8.8255G 694:2013PNAS..110E4591W 688:(48): E4591–E4600. 314:The development of 2175:Cellular processes 2088:EHD protein family 1006:mediated transport 976:Membrane transport 904:10.1039/D0SC90189J 757:10.1039/C6NR00506C 246: 216:(as well as other 138: 2162: 2161: 2145: 2144: 2041: 2040: 1736:Vesicle formation 1534: 1533: 1399: 1398: 1148: 1147: 1144: 1143: 994:Passive transport 939:CytoChemistry.net 787:(30): 7704–7708. 781:Angewandte Chemie 743:(15): 8255–8265. 616:. 206, 2073-2082. 605:10.1242/jeb.00298 429:978-1-4614-6527-0 130: 129: 122: 104: 16:(Redirected from 2182: 1740: 1739: 1733: 1732: 1213: 1212: 1204: 1203: 1199:Synaptic vesicle 1182:Membrane protein 1175: 1168: 1161: 1152: 1151: 1080: 1079: 1037:Active transport 1002:Simple diffusion 969: 962: 955: 946: 945: 926: 925: 915: 892:Chemical Science 883: 877: 876: 852: 846: 845: 835: 811: 805: 804: 775: 769: 768: 732: 726: 725: 715: 705: 673: 667: 666: 656: 624: 618: 617: 607: 583: 577: 576: 566: 556: 532: 526: 525: 515: 483: 477: 476: 440: 434: 433: 407: 363:Bulk endocytosis 125: 118: 114: 111: 105: 103: 62: 38: 30: 21: 2190: 2189: 2185: 2184: 2183: 2181: 2180: 2179: 2165: 2164: 2163: 2158: 2157: 2141: 2076: 2037: 2016: 1995: 1969: 1945: 1932: 1919: 1885: 1836: 1797: 1729:Other/ungrouped 1724: 1691: 1659: 1610: 1530: 1516: 1497: 1395: 1359: 1193: 1179: 1149: 1140: 1126: 1069: 1031: 988: 978: 973: 935: 930: 929: 884: 880: 853: 849: 812: 808: 776: 772: 733: 729: 674: 670: 639:(11): 596–605. 625: 621: 584: 580: 533: 529: 484: 480: 441: 437: 430: 408: 401: 396: 359: 340: 338:Characteristics 279: 238: 189: 169:plasma membrane 147:), also called 126: 115: 109: 106: 63: 61: 51: 39: 28: 23: 22: 15: 12: 11: 5: 2188: 2178: 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765:27031090 722:24218552 663:19836955 614:12756289 573:16236165 522:27499021 465:29410531 357:See also 290:receptor 252:via the 236:Function 226:endosome 205:clathrin 197:caveolin 177:vesicles 161:proteins 157:hormones 2055:Dynamin 2000:BLOC-3: 1974:BLOC-2: 1965:BLOC153 1365:R-SNARE 1326:Munc-18 1217:Q-SNARE 1075:Cytosis 1017:Osmosis 913:7495901 857:bioRxiv 745:Bibcode 713:3845133 690:Bibcode 654:2796618 575:. 2:43. 564:1276819 513:5418658 473:4380108 328:dynamin 301:T cells 214:dynamin 193:ligands 187:Process 165:viruses 94:scholar 2130:VPS33B 2125:VPS13B 2021:Coats: 1960:DTNBP1 1951:BLOC-1 1633:SEC24A 1629:SEC23A 1355:STXBP6 1350:STXBP5 1345:STXBP4 1340:STXBP3 1335:STXBP2 1330:STXBP1 1230:SNAP29 1225:SNAP25 920:  910:  871:  840:  799:  763:  720:  710:  661:  651:  612:  571:  561:  520:  510:  471:  463:  426:  96:  89:  82:  75:  67:  2137:SYNRG 2081:Other 2033:TIP47 1928:LMAN1 1915:AP4S1 1910:AP4M1 1905:AP4E1 1900:AP4B1 1881:AP3S2 1876:AP3S1 1871:AP3M2 1866:AP3M1 1861:AP3D1 1856:AP3B2 1851:AP3B1 1832:AP2S1 1827:AP2M1 1822:AP2B1 1817:AP2A2 1812:AP2A1 1793:AP1S3 1788:AP1S2 1783:AP1S1 1778:AP1M2 1773:AP1M1 1768:AP1G2 1763:AP1G1 1758:AP1B1 1753:AP1AR 1655:SAR1A 1642:SEC31 1638:SEC13 1616:COPII 1593:COPZ2 1588:COPZ1 1583:COPG2 1563:COPB2 1558:COPB1 1526:RAB3A 1502:Other 1493:SYT17 1488:SYT16 1483:SYT15 1478:SYT14 1473:SYT13 1468:SYT12 1463:SYT11 1458:SYT10 1391:VAMP3 1386:VAMP2 1381:VAMP1 1317:STX19 1312:STX18 1307:STX17 1302:STX16 1297:STX12 1292:STX11 1287:STX10 1247:STX1B 1242:STX1A 1208:SNARE 1190:TC 1F 869:S2CID 469:S2CID 101:JSTOR 87:books 2107:EHD4 2102:EHD3 2097:EHD2 2092:EHD1 2070:DNM3 2065:DNM2 2060:DNM1 2012:HPS4 2007:HPS1 1991:HPS6 1986:HPS5 1981:HPS3 1941:LYST 1719:CAV3 1714:CAV2 1709:CAV1 1687:CLTC 1682:CLTB 1677:CLTA 1578:COPG 1573:COPE 1553:COPA 1540:COPI 1453:SYT9 1448:SYT8 1443:SYT7 1438:SYT6 1433:SYT5 1428:SYT4 1423:SYT3 1418:SYT2 1413:SYT1 1377:VAMP 1282:STX8 1277:STX7 1272:STX6 1267:STX5 1262:STX4 1257:STX3 1252:STX2 918:PMID 838:PMID 797:PMID 761:PMID 718:PMID 659:PMID 610:PMID 569:PMID 518:PMID 492:Cell 461:PMID 424:ISBN 309:CCR5 199:and 73:news 1665:RME 1606:ARF 908:PMC 900:doi 861:doi 828:doi 789:doi 753:doi 708:PMC 698:doi 686:110 649:PMC 641:doi 600:doi 596:206 559:PMC 549:doi 508:PMC 500:doi 496:166 453:doi 416:doi 267:EGF 250:LDL 203:), 145:RME 56:by 2171:: 2123:: 2090:: 1653:: 1604:: 1524:: 1379:: 1328:: 1184:: 916:. 906:. 896:11 894:. 890:. 867:. 836:. 824:22 822:. 818:. 795:. 785:52 783:. 759:. 751:. 739:. 716:. 706:. 696:. 684:. 680:. 657:. 647:. 637:19 635:. 631:. 608:. 594:. 590:. 567:. 557:. 543:. 539:. 516:. 506:. 494:. 490:. 467:. 459:. 449:19 447:. 422:. 402:^ 303:, 159:, 155:, 1953:: 1893:: 1844:: 1805:: 1746:: 1721:) 1707:( 1667:/ 1640:/ 1631:/ 1375:/ 1192:) 1188:( 1174:e 1167:t 1160:v 1008:) 968:e 961:t 954:v 924:. 902:: 875:. 863:: 844:. 830:: 803:. 791:: 767:. 755:: 747:: 741:8 724:. 700:: 692:: 665:. 643:: 602:: 551:: 545:2 524:. 502:: 475:. 455:: 432:. 418:: 171:( 143:( 123:) 117:( 112:) 108:( 98:· 91:· 84:· 77:· 50:. 20:)

Index

Clathrin-mediated endocytosis

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metabolites
hormones
proteins
viruses
plasma membrane
invagination
vesicles
receptors
ligands
caveolin
lipid raft
clathrin
triskelions
dynamin
BAR domain
clathrin-coated vesicle
endosome

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