1504:
330:
307:
229:
204:
3070:
3055:
336:
235:
581:
5178:
1237:
31:
1229:(1021) residue. The substrate binds near the T1 center and is oxidized by the T1 Cu ion forming the reduced Cu oxidation state. The reduced T1 Cu then transfers the electron through the one Cys and two His bridging residues to the tricopper center. After four electrons have been transferred from the substrates to the copper centers, an O
1348:. The sample is spun and separated; it is stored around 4°C Celsius for three days. This test is to determine if there are signs of Wilson disease. Another test that can be done is a urine copper level test; this has been found to be less accurate than the blood test. A liver tissue test can be done as well.
1170:
in its structure. Ceruloplasmin carries more than 95% of the total copper in healthy human plasma. The rest is accounted for by macroglobulins. Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe (ferrous iron) into Fe (ferric iron), therefore
2184:
Ziakas A, Gavrilidis S, Souliou E, Giannoglou G, Stiliadis I, Karvounis H, Efthimiadis G, Mochlas S, Vayona MA, Hatzitolios A, Savopoulos C, Pidonia I, Parharidis G (2009). "Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe
1178:
Despite extensive research, much is still unknown about the exact functions of CP, most of the functions are attributed to CP focus on the presence of the Cu centers. These include copper transport to deliver the Cu to extrahepatic tissues, amine oxidase activity that controls the level of biogenic
57:
2766:
Rask L, Valtersson C, Anundi H, Kvist S, Eriksson U, Dallner G, Peterson PA (Jan 1983). "Subcellular localization in normal and vitamin A-deficient rat liver of vitamin A serum transport proteins, albumin, ceruloplasmin and class I major histocompatibility antigens".
1240:
Figure 2: Close-up view of the human plasma CP active site consisting of the T1 copper center (left) and trinuclear copper center (right) showing the coordinating side chains. PDB code: 1KCW. Atom colors: Cu = grey ; O = red ; N = blue ; S =
1258:
is involved in the selective translational silencing of the
Ceruloplasmin transcript. The silencing requires binding of a cytosolic inhibitor complex called IFN-gamma-activated inhibitor of translation (GAIT) to the GAIT element.
1221:(T2) copper ion. The two T3 copper ions are bridged by a hydroxide ligand while another hydroxide ligand links the T2 copper ion to the protein. The T1 center is bridged to the tricopper center by two
343:
242:
1337:
Copper availability doesn't affect the translation of the nascent protein. However, the apoenzyme without copper is unstable. Apoceruloplasmin is largely degraded intracellularly in the
2433:
Giurgea N, Constantinescu MI, Stanciu R, Suciu S, Muresan A (Feb 2005). "Ceruloplasmin - acute-phase reactant or endogenous antioxidant? The case of cardiovascular disease".
1726:
Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (May 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively".
3069:
3851:
2507:
Polosatov MV, Klimov PK, Masevich CG, Samartsev MA, WĂĽnsch E (Apr 1979). "Interaction of synthetic human big gastrin with blood proteins of man and animals".
1947:"Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region"
824:
4837:
4810:
4761:
4700:
3983:
805:
4715:
4842:
151:
4738:
4590:
4017:
4613:
3416:
3054:
1587:
2941:"Primary structure of a histidine-rich proteolytic fragment of human ceruloplasmin. I. Amino acid sequence of the cyanogen bromide peptides"
1569:
1341:
and the small amount that is released has a short circulation half life of 5 hours as compared to the 5.5 days for the holo-ceruloplasmin.
3515:
4681:
4172:
3401:
3199:
3110:
1052:
1213:(T1) mononuclear copper site and a trinuclear copper center ~ 12-13 Ă… away (see figure 2). The tricopper center consists of two
2059:
Scheinberg IH, Gitlin D (Oct 1952). "Deficiency of ceruloplasmin in patients with hepatolenticular degeneration (Wilson's disease)".
1059:
4653:
4705:
4357:
2277:
Wolf TL, Kotun J, Meador-Woodruff JH (Sep 2006). "Plasma copper, iron, ceruloplasmin and ferroxidase activity in schizophrenia".
2729:
Mercer JF, Grimes A (Jul 1986). "Isolation of a human ceruloplasmin cDNA clone that includes the N-terminal leader sequence".
3149:
3034:
1929:
1813:
1552:
5198:
4854:
54:
4583:
3406:
1531:
1175:, which can carry iron only in the ferric state. The molecular weight of human ceruloplasmin is reported to be 151kDa.
4010:
3447:
2676:
Yang F, Naylor SL, Lum JB, Cutshaw S, McCombs JL, Naberhaus KH, McGill JR, Adrian GS, Moore CM, Barnett DR (May 1986).
1267:
Like any other plasma protein, levels drop in patients with hepatic disease due to reduced synthesizing capabilities.
4897:
3452:
1771:"Investigations in serum copper. II. Isolation of the Copper containing protein, and a description of its properties"
329:
4864:
1507:
1197:
Ceruloplasmin is a relatively large enzyme (~10nm); the larger size prevents the bound copper from being lost in a
2456:"Chemical evidence that proteolytic cleavage causes the heterogeneity present in human ceruloplasmin preparations"
4671:
4512:
3508:
3467:
1556:
1535:
306:
2230:"Cellular multitasking: the dual role of human Cu-ATPases in cofactor delivery and intracellular copper balance"
1363:. In the brain, this iron overload may lead to characteristic neurologic signs and symptoms, such as cerebellar
4576:
4165:
3962:
3194:
3103:
1996:"Regulation of macrophage ceruloplasmin gene expression: one paradigm of 3'-UTR-mediated translational control"
1190:
Mutations have been known to disrupt the binding of copper to CP and will disrupt iron metabolism and cause an
869:
2404:
Mazumder B, Seshadri V, Fox PL (Feb 2003). "Translational control by the 3'-UTR: the ends specify the means".
5203:
5053:
4003:
1489:
1147:, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism.
850:
3693:
3264:
2608:"Primary structure of rat ceruloplasmin and analysis of tissue-specific gene expression during development"
228:
203:
131:
5208:
4859:
4108:
3309:
5168:
3501:
3477:
3278:
3131:
1607:"Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule"
1179:
amines in intestinal fluids and plasma, removal of oxygen and other free radicals from plasma, and the
1503:
1233:
binds at the tricopper center and undergoes a four-electron reduction to form two molecules of water.
5154:
5141:
5128:
5115:
5102:
5089:
5076:
5038:
4158:
4042:
3957:
3376:
3096:
3027:
342:
241:
118:
5223:
5048:
5002:
4945:
4819:
4751:
4695:
4604:
4548:
4063:
3568:
3268:
2322:"High ceruloplasmin levels are associated with obsessive compulsive disorder: a case control study"
1160:
1035:
1027:
1023:
976:
968:
964:
960:
335:
234:
175:
139:
5228:
4950:
4719:
4553:
3628:
3578:
3564:
3482:
3356:
3304:
2643:"Human ceruloplasmin. Tissue-specific expression of transcripts produced by alternative splicing"
1447:
1307:
3078:: CERULOPLASMIN REVISITED: STRUCTURAL AND FUNCTIONAL ROLES OF VARIOUS METAL CATION BINDING SITES
2986:
1031:
1002:
972:
939:
4415:
4185:
3472:
2641:
Yang FM, Friedrichs WE, Cupples RL, Bonifacio MJ, Sanford JA, Horton WA, Bowman BH (Jun 1990).
1479:
1251:
1803:
4971:
4890:
4530:
4321:
4285:
4202:
4073:
3654:
3333:
1314:
1180:
5043:
4626:
4522:
4504:
4264:
4259:
4254:
3911:
3727:
3442:
3338:
3020:
2899:
2846:
2689:
2467:
2068:
1680:
1618:
1469:
1463:
1372:
217:
181:
2388:
1842:
8:
5218:
5007:
4849:
4824:
4134:
4068:
4026:
3906:
3846:
3592:
3582:
3572:
3154:
1330:
2903:
2850:
2693:
2471:
2072:
2035:
1684:
1622:
159:
5213:
4940:
4829:
4568:
4540:
4078:
3932:
3824:
3393:
2821:
2754:
2554:
2529:
2348:
2321:
2302:
2254:
2229:
2210:
1892:
1865:
1751:
1413:
1356:
1275:
163:
2957:
2940:
2922:
2887:
2869:
2834:
2796:
Kressner MS, Stockert RJ, Morell AG, Sternlieb I (1984). "Origins of biliary copper".
2712:
2677:
2659:
2642:
2624:
2607:
2589:
2572:
2490:
2455:
2417:
2012:
1995:
1971:
1946:
1703:
1668:
1641:
1606:
739:
734:
729:
724:
719:
714:
709:
693:
688:
683:
678:
673:
668:
663:
647:
642:
637:
632:
627:
622:
4486:
3941:
3841:
3784:
3001:
2992:
2962:
2927:
2874:
2813:
2784:
2780:
2746:
2742:
2717:
2664:
2629:
2594:
2559:
2516:
2495:
2442:
2421:
2392:
2353:
2294:
2259:
2202:
2166:
2125:
2120:
2103:
2084:
2017:
1976:
1925:
1897:
1846:
1809:
1743:
1708:
1664:
1646:
111:
47:
2825:
2758:
2306:
1962:
1787:
1770:
1755:
4986:
4981:
4955:
4883:
4690:
4402:
4193:
3524:
3411:
2952:
2917:
2907:
2864:
2854:
2805:
2776:
2738:
2707:
2697:
2654:
2619:
2584:
2549:
2541:
2485:
2475:
2413:
2384:
2343:
2333:
2286:
2249:
2241:
2194:
2156:
2115:
2076:
2007:
1966:
1958:
1887:
1877:
1838:
1782:
1735:
1698:
1688:
1636:
1626:
1510:, comparing blood content of ceruloplasmin (shown in gray) with other constituents.
422:
353:
297:
252:
2214:
143:
5033:
5017:
4930:
4494:
4440:
4276:
4088:
4047:
3683:
3604:
3260:
3185:
3123:
2888:"Complete amino acid sequence of a 50,000-dalton fragment of human ceruloplasmin"
2290:
2161:
2144:
2080:
1474:
1437:
1433:
1318:
1198:
1140:
397:
167:
1592:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1574:
National Center for
Biotechnology Information, U.S. National Library of Medicine
5182:
5071:
5012:
4600:
4222:
4150:
3799:
3756:
3673:
3544:
3383:
3251:
2892:
Proceedings of the
National Academy of Sciences of the United States of America
2839:
Proceedings of the
National Academy of Sciences of the United States of America
2682:
Proceedings of the
National Academy of Sciences of the United States of America
2460:
Proceedings of the
National Academy of Sciences of the United States of America
1673:
Proceedings of the
National Academy of Sciences of the United States of America
1611:
Proceedings of the
National Academy of Sciences of the United States of America
1401:
1395:
1344:
Ceruloplasmin can be measured by means of a blood test; this can be done using
1303:
1218:
1214:
1210:
498:
2981:
2245:
1375:. Excess iron may also deposit in the liver, pancreas, and retina, leading to
5192:
4976:
4935:
3916:
3898:
3836:
3794:
3790:
3457:
3283:
3246:
3088:
2198:
1882:
1805:
Endogenous Toxins: Targets for
Disease Treatment and Prevention, 2 Volume Set
1484:
1418:
1360:
1290:
1191:
609:
2833:
Takahashi N, Bauman RA, Ortel TL, Dwulet FE, Wang CC, Putnam FW (Jan 1983).
2702:
2480:
1693:
558:
436:
4925:
4778:
4295:
3588:
3532:
3241:
2809:
2678:"Characterization, mapping, and expression of the human ceruloplasmin gene"
2446:
2425:
2396:
2357:
2338:
2298:
2263:
2206:
2170:
2088:
2021:
1980:
1901:
1850:
1459:
1284:
1255:
415:
194:
2966:
2931:
2912:
2878:
2859:
2817:
2788:
2750:
2721:
2668:
2633:
2598:
2563:
2129:
1747:
1712:
1650:
1631:
1500:
Normal blood concentration of ceruloplasmin in humans is 20–50 mg/dL.
1099:
1094:
5149:
5084:
4920:
4728:
4477:
4384:
4379:
4352:
4250:
4245:
4139:
4118:
4103:
3947:
3937:
3829:
3780:
3717:
3698:
3658:
3647:
3615:
3421:
3273:
3189:
2520:
2499:
1345:
1184:
1172:
1119:
914:
895:
580:
2573:"Characterization of an interaction between protein C and ceruloplasmin"
1429:
Greater-than-normal ceruloplasmin levels may indicate or be noticed in:
1163:
4765:
4742:
4617:
4374:
4241:
4181:
3995:
3878:
2375:
Hellman NE, Gitlin JD (2002). "Ceruloplasmin metabolism and function".
2320:
Virit O, Selek S, Bulut M, Savas HA, Celik H, Erel O, Herken H (2008).
1829:
Hellman NE, Gitlin JD (2002). "Ceruloplasmin metabolism and function".
1739:
1338:
1322:
1144:
314:
211:
147:
2545:
88:
84:
80:
76:
5123:
5097:
4362:
4113:
3883:
3870:
3742:
3722:
3462:
3426:
1442:
1380:
1376:
1222:
769:
381:
368:
280:
267:
155:
3493:
5177:
4343:
4330:
4300:
4290:
4236:
4211:
4093:
3764:
3732:
3535:
1453:
1391:
Lower-than-normal ceruloplasmin levels may indicate the following:
1368:
1083:
1663:
4769:
4463:
4458:
4425:
4034:
3861:
3804:
3737:
3119:
3063:: X-RAY CRYSTAL STRUCTURE OF HUMAN CERULOPLASMIN AT 3.0 ANGSTROMS
3006:
2996:
2432:
2183:
1236:
1226:
881:
836:
754:
750:
2506:
1725:
1139:-carrying protein in the blood, and in addition plays a role in
135:
5136:
4906:
4098:
3888:
3554:
3234:
3229:
3224:
3219:
3214:
3209:
3204:
2835:"Internal triplication in the structure of human ceruloplasmin"
2795:
1924:. California, USA: University Science Books. pp. 426–442.
1407:
1364:
1167:
1156:
1136:
1122:
1067:
791:
589:
3012:
2640:
5110:
4798:
4793:
4788:
4657:
4430:
4410:
3952:
3169:
3164:
3159:
3144:
3139:
1326:
1299:
1171:
assisting in its transport in the plasma in association with
2991:
Overview of all the structural information available in the
2142:
1404:(Menkes kinky hair syndrome) (rare – UK incidence 1/100,000)
122:, CP-2, ceruloplasmin (ferroxidase), Ceruloplasmin, AB073614
4783:
4641:
4636:
4631:
4453:
4448:
4347:
4231:
3371:
3366:
3361:
1129:
4875:
2832:
2227:
2143:
Elkassabany NM, Meny GM, Doria RR, Marcucci C (Apr 2008).
1944:
2765:
4598:
2276:
1355:), which are very rare, can lead to the genetic disease
405:
2527:
30:
2938:
2453:
2228:
Lutsenko S, Gupta A, Burkhead JL, Zuzel V (Aug 2008).
1945:
Sampath P, Mazumder B, Seshadri V, Fox PL (Mar 2003).
5166:
4320:
570:
2675:
2319:
1667:, Funk WD, van Oost BA, MacGillivray RT (Jul 1986).
1604:
1298:
Copper does not cross the intestinal barrier due to
2982:
GeneReviews/NCBI/NIH/UW entry on Aceruloplasminemia
2403:
1795:
1143:. It was first described in 1948. Another protein,
4701:4-Hydroxy-3-methylbut-2-enyl diphosphate reductase
1993:
1669:"Complete cDNA sequence of human preceruloplasmin"
1548:
1546:
1544:
1527:
1525:
1523:
2530:"Caeruloplasmin biosynthesis by the human uterus"
2528:Schilsky ML, Stockert RJ, Pollard JW (Dec 1992).
1383:abnormalities, and loss of vision, respectively.
1166:) synthesized in the liver containing 6 atoms of
352:
251:
5190:
4180:
2939:Kingston IB, Kingston BL, Putnam FW (Apr 1980).
2454:Kingston IB, Kingston BL, Putnam FW (Dec 1977).
2058:
1866:"Retinal iron homeostasis in health and disease"
1801:
1768:
1541:
1520:
4201:
3118:
2036:"Ceruloplasmin Test: MedlinePlus Medical Test"
1553:GRCm38: Ensembl release 89: ENSMUSG00000003617
4891:
4584:
4166:
4011:
3509:
3104:
3028:
2605:
2374:
1828:
1605:Takahashi N, Ortel TL, Putnam FW (Jan 1984).
1209:The multicopper active site of CP contains a
648:oxidoreductase activity, acting on metal ions
2885:
2728:
2313:
2270:
2221:
2177:
2136:
1987:
1938:
4813:: Acting on X-H and Y-H to form an X-Y bond
1863:
1532:GRCh38: Ensembl release 89: ENSG00000047457
4898:
4884:
4591:
4577:
4173:
4159:
4018:
4004:
3516:
3502:
3200:Insulin-like growth factor binding protein
3111:
3097:
3035:
3021:
1994:Mazumder B, Sampath P, Fox PL (Oct 2005).
1719:
1657:
1598:
1359:, characterized by hyperferritinemia with
1287:/trace metal deficiency in the food source
3984:disorders of globin and globulin proteins
2956:
2921:
2911:
2868:
2858:
2711:
2701:
2658:
2623:
2588:
2570:
2553:
2489:
2479:
2347:
2337:
2253:
2160:
2119:
2011:
1970:
1891:
1881:
1808:. John Wiley & Sons. pp. 405–6.
1786:
1702:
1692:
1640:
1630:
1313:Delivery of copper into the lumen of the
4025:
1502:
1270:Mechanisms of low ceruloplasmin levels:
1262:
1235:
1204:
4706:7-Hydroxymethyl chlorophyll a reductase
4358:Iron-responsive element-binding protein
2234:Archives of Biochemistry and Biophysics
1919:
1822:
725:post-translational protein modification
16:Mammalian protein found in Homo sapiens
5191:
2101:
4879:
4572:
4154:
3999:
3523:
3497:
3092:
3016:
2389:10.1146/annurev.nutr.22.012502.114457
1915:
1913:
1911:
1843:10.1146/annurev.nutr.22.012502.114457
1351:Mutations in the ceruloplasmin gene (
357:
318:
313:
256:
215:
210:
4855:Tetrahydrocannabinolic acid synthase
1857:
1225:(His1020, His1022) residues and one
525:vestibular membrane of cochlear duct
2945:The Journal of Biological Chemistry
2647:The Journal of Biological Chemistry
2612:The Journal of Biological Chemistry
2577:The Journal of Biological Chemistry
1728:Somatic Cell and Molecular Genetics
1495:
13:
2987:OMIM entries on Aceruloplasminemia
2606:Fleming RE, Gitlin JD (May 1990).
2367:
1908:
1293:, due to induced copper deficiency
14:
5240:
3453:Cholesterylester transfer protein
2975:
2886:Dwulet FE, Putnam FW (Feb 1981).
1398:(a rare copper storage disease).
1281:Copper levels are low in general
1274:Gene expression genetically low (
1183:from cells for transport through
1125:that in humans is encoded by the
5176:
4865:Dichlorochromopyrrolate synthase
3068:
3053:
2121:10.1203/00006450-199809000-00001
1769:Holmberg CG, Laurell CB (1948).
1508:Reference ranges for blood tests
579:
341:
334:
328:
305:
240:
233:
227:
202:
29:
4672:(Methionine synthase) reductase
4513:Phosphoric acids and phosphates
3468:Latent TGF-beta binding protein
3417:Photosynthetic Reaction Centers
3042:
2095:
2052:
2028:
1963:10.1128/MCB.23.5.1509-1519.2003
1870:Frontiers in Aging Neuroscience
1788:10.3891/acta.chem.scand.02-0550
3963:Extracellular matrix protein 1
3402:Plant Light-Harvesting Complex
3195:Growth hormone binding protein
2571:Walker FJ, Fay PJ (Feb 1990).
2509:Acta Hepato-Gastroenterologica
2406:Trends in Biochemical Sciences
2326:Behavioral and Brain Functions
1951:Molecular and Cellular Biology
1922:Biological Inorganic Chemistry
1762:
1580:
1562:
590:More reference expression data
559:More reference expression data
459:olfactory zone of nasal mucosa
1:
4843:(-)-bisdechlorogeodin-forming
4838:(+)-bisdechlorogeodin-forming
4246:Ferroportin (SLC11A3/SLC40A1)
3005:(Human Ceruloplasmin) at the
2958:10.1016/S0021-9258(19)85822-2
2660:10.1016/S0021-9258(18)87015-6
2625:10.1016/S0021-9258(19)39171-9
2590:10.1016/S0021-9258(19)39903-X
2418:10.1016/S0968-0004(03)00002-1
2013:10.1016/S1016-8478(23)13213-4
1802:O'Brien PJ, Bruce WR (2009).
1514:
1490:Obsessive-compulsive disorder
1386:
1245:
720:cellular iron ion homeostasis
326:
225:
4684:: Acting on CH or CH2 groups
3694:Sex hormone-binding globulin
3265:Sex hormone binding globulin
2781:10.1016/0014-4827(83)90112-X
2743:10.1016/0014-5793(86)80739-6
2291:10.1016/j.schres.2006.05.027
2162:10.1097/ALN.0b013e3181672668
2081:10.1126/science.116.3018.484
471:Epithelium of choroid plexus
7:
5199:Genes on human chromosome 3
4905:
4860:Cannabidiolic acid synthase
4109:Haptoglobin-related protein
3310:Calmodulin-binding proteins
1864:Song D, Dunaief JL (2013).
1150:
1135:Ceruloplasmin is the major
689:endoplasmic reticulum lumen
10:
5245:
3478:Membrane transport protein
3279:Thyroxine-binding globulin
2769:Experimental Cell Research
2377:Annual Review of Nutrition
1831:Annual Review of Nutrition
5062:
5054:Michaelis–Menten kinetics
5026:
4995:
4964:
4913:
4809:
4760:
4737:
4714:
4680:
4652:
4612:
4539:
4521:
4503:
4485:
4476:
4439:
4401:
4339:
4313:
4275:
4221:
4210:
4192:
4127:
4056:
4033:
3975:
3958:Vitamin D-binding protein
3925:
3897:
3869:
3860:
3817:
3773:
3755:
3708:
3681:
3672:
3637:
3602:
3552:
3543:
3531:
3435:
3407:Orange Carotenoid Protein
3392:
3349:
3292:
3178:
3130:
3048:
2246:10.1016/j.abb.2008.05.005
1588:"Mouse PubMed Reference:"
1570:"Human PubMed Reference:"
1424:
1155:Ceruloplasmin (CP) is an
1098:
1093:
1089:
1082:
1066:
1053:Chr 3: 149.16 – 149.22 Mb
1047:
1020:
1016:
999:
995:
988:
957:
953:
936:
932:
925:
912:
908:
893:
889:
880:
867:
863:
848:
844:
835:
822:
818:
803:
799:
790:
775:
768:
764:
748:
608:
604:
587:
578:
569:
556:
505:
496:
467:mucosa of paranasal sinus
463:bronchial epithelial cell
443:
434:
404:
396:
392:
375:
362:
325:
304:
295:
291:
274:
261:
224:
201:
192:
188:
179:
174:
129:
126:
116:
109:
104:
73:
68:
51:
46:
41:
37:
28:
23:
4946:Diffusion-limited enzyme
4820:Isopenicillin N synthase
4752:Nitrogenase (flavodoxin)
4696:Ribonucleotide reductase
4549:Calcium-sensing receptor
4296:Calreticulin/mobilferrin
4064:Alpha 1-antichymotrypsin
3569:Alpha 1-antichymotrypsin
3269:Androgen binding protein
2199:10.1177/0003319708314249
2145:"Green plasma-revisited"
1883:10.3389/fnagi.2013.00024
4554:Calcium-binding protein
3852:7S seed storage protein
3629:Retinol binding protein
3483:Odorant binding protein
3357:Retinol binding protein
3305:Calcium-binding protein
2703:10.1073/pnas.83.10.3257
2534:The Biochemical Journal
2481:10.1073/pnas.74.12.5377
2435:Medical Science Monitor
1694:10.1073/pnas.83.14.5086
1448:oral contraceptive pill
1308:Occipital horn syndrome
1060:Chr 3: 20.01 – 20.06 Mb
638:oxidoreductase activity
3473:Major urinary proteins
2810:10.1002/hep.1840040512
2339:10.1186/1744-9081-4-52
2279:Schizophrenia Research
2102:Gitlin JD (Sep 1998).
1511:
1252:cis-regulatory element
1242:
5039:Eadie–Hofstee diagram
4972:Allosteric regulation
4531:Magnesium transporter
4322:Iron-binding proteins
4286:Duodenal cytochrome B
4074:Alpha 2-macroglobulin
3655:alpha-2-Macroglobulin
3334:Iron-binding proteins
2913:10.1073/pnas.78.2.790
2860:10.1073/pnas.80.1.115
1632:10.1073/pnas.81.2.390
1506:
1321:network is absent in
1263:Clinical significance
1239:
1217:(T3) coppers and one
1205:Active site structure
679:extracellular exosome
479:right coronary artery
451:palpebral conjunctiva
5204:Acute-phase proteins
5049:Lineweaver–Burk plot
4741:: Acting on reduced
4720:iron–sulfur proteins
4627:Superoxide dismutase
4523:Magnesium metabolism
4505:Phosphate metabolism
4255:Transferrin receptor
4027:Acute-phase proteins
3912:Bovine serum albumin
3728:Beta-2 microglobulin
3443:Acyl carrier protein
3339:Transferrin receptor
2104:"Aceruloplasminemia"
1470:rheumatoid arthritis
1464:acute-phase reactant
1373:extrapyramidal signs
740:iron ion homeostasis
715:copper ion transport
669:extracellular region
633:ferroxidase activity
320:Chromosome 3 (mouse)
218:Chromosome 3 (human)
69:List of PDB id codes
42:Available structures
4850:Aureusidin synthase
4825:Columbamine oxidase
4069:Alpha 1-antitrypsin
3907:Human serum albumin
3847:11S globulin family
3593:Heparin cofactor II
3583:Alpha 2-antiplasmin
3573:Alpha 1-antitrypsin
3463:GTP-binding protein
2904:1981PNAS...78..790D
2851:1983PNAS...80..115T
2694:1986PNAS...83.3257Y
2472:1977PNAS...74.5377K
2073:1952Sci...116..484S
2000:Molecules and Cells
1685:1986PNAS...83.5086K
1623:1984PNAS...81..390T
1480:Alzheimer's disease
684:extracellular space
664:blood microparticle
447:right lobe of liver
5209:Chemical pathology
5008:Enzyme superfamily
4941:Enzyme promiscuity
4834:Sulochrin oxidase
4830:Reticuline oxidase
4541:Calcium metabolism
4079:C-reactive protein
3933:C-reactive protein
3825:Beta-lactoglobulin
2185:unstable angina".
2108:Pediatric Research
1920:Bertini I (2007).
1740:10.1007/BF01535211
1512:
1458:acute and chronic
1414:Aceruloplasminemia
1357:aceruloplasminemia
1276:aceruloplasminemia
1243:
1201:during transport.
870:ENSMUSG00000003617
735:iron ion transport
703:Biological process
674:lysosomal membrane
657:Cellular component
643:copper ion binding
616:Molecular function
533:tibiofemoral joint
513:epithelium of lens
509:left lobe of liver
5164:
5163:
4873:
4872:
4566:
4565:
4562:
4561:
4487:Sodium metabolism
4472:
4471:
4403:Copper metabolism
4397:
4396:
4393:
4392:
4309:
4308:
4148:
4147:
3993:
3992:
3971:
3970:
3942:Alpha-lactalbumin
3842:Alpha-lactalbumin
3813:
3812:
3785:Fetal fibronectin
3751:
3750:
3668:
3667:
3525:Globular proteins
3491:
3490:
3086:
3085:
2546:10.1042/bj2880657
1931:978-1-891389-43-6
1815:978-3-527-32363-0
1109:
1108:
1105:
1104:
1078:
1077:
1043:
1042:
1010:
1009:
984:
983:
947:
946:
921:
920:
902:
901:
876:
875:
857:
856:
831:
830:
812:
811:
760:
759:
628:metal ion binding
623:chaperone binding
600:
599:
596:
595:
565:
564:
552:
551:
529:lactiferous gland
490:
489:
388:
387:
287:
286:
100:
99:
96:
95:
52:Ortholog search:
5236:
5181:
5180:
5172:
5044:Hanes–Woolf plot
4987:Enzyme activator
4982:Enzyme inhibitor
4956:Enzyme catalysis
4900:
4893:
4886:
4877:
4876:
4691:Xanthine oxidase
4593:
4586:
4579:
4570:
4569:
4483:
4482:
4318:
4317:
4219:
4218:
4208:
4207:
4199:
4198:
4194:Transition metal
4186:Metal metabolism
4175:
4168:
4161:
4152:
4151:
4020:
4013:
4006:
3997:
3996:
3867:
3866:
3711:
3687:
3684:carrier proteins
3679:
3678:
3640:
3608:
3605:carrier proteins
3558:
3550:
3549:
3541:
3540:
3518:
3511:
3504:
3495:
3494:
3412:Phycobiliprotein
3124:carrier proteins
3113:
3106:
3099:
3090:
3089:
3072:
3057:
3037:
3030:
3023:
3014:
3013:
2970:
2960:
2935:
2925:
2915:
2882:
2872:
2862:
2829:
2792:
2762:
2725:
2715:
2705:
2672:
2662:
2637:
2627:
2602:
2592:
2567:
2557:
2524:
2503:
2493:
2483:
2450:
2429:
2400:
2362:
2361:
2351:
2341:
2317:
2311:
2310:
2274:
2268:
2267:
2257:
2225:
2219:
2218:
2181:
2175:
2174:
2164:
2140:
2134:
2133:
2123:
2099:
2093:
2092:
2056:
2050:
2049:
2047:
2046:
2032:
2026:
2025:
2015:
1991:
1985:
1984:
1974:
1942:
1936:
1935:
1917:
1906:
1905:
1895:
1885:
1861:
1855:
1854:
1826:
1820:
1819:
1799:
1793:
1792:
1790:
1766:
1760:
1759:
1723:
1717:
1716:
1706:
1696:
1661:
1655:
1654:
1644:
1634:
1602:
1596:
1595:
1584:
1578:
1577:
1566:
1560:
1550:
1539:
1529:
1496:Reference ranges
1331:Wilson's disease
1091:
1090:
1062:
1055:
1038:
1014:
1013:
1005:
993:
992:
989:RefSeq (protein)
979:
951:
950:
942:
930:
929:
906:
905:
887:
886:
861:
860:
842:
841:
816:
815:
797:
796:
766:
765:
606:
605:
592:
583:
576:
575:
561:
501:
499:Top expressed in
494:
493:
455:nasal epithelium
439:
437:Top expressed in
432:
431:
411:
410:
394:
393:
384:
371:
360:
345:
338:
332:
321:
309:
293:
292:
283:
270:
259:
244:
237:
231:
220:
206:
190:
189:
184:
170:
121:
114:
91:
66:
65:
60:
39:
38:
33:
21:
20:
5244:
5243:
5239:
5238:
5237:
5235:
5234:
5233:
5224:Iron metabolism
5189:
5188:
5187:
5175:
5167:
5165:
5160:
5072:Oxidoreductases
5058:
5034:Enzyme kinetics
5022:
5018:List of enzymes
4991:
4960:
4931:Catalytic triad
4909:
4904:
4874:
4869:
4805:
4756:
4733:
4710:
4676:
4648:
4608:
4601:oxidoreductases
4597:
4567:
4558:
4535:
4517:
4499:
4468:
4441:Zinc metabolism
4435:
4389:
4335:
4305:
4277:Iron(III) oxide
4271:
4213:
4203:Iron metabolism
4188:
4179:
4149:
4144:
4123:
4052:
4029:
4024:
3994:
3989:
3988:
3967:
3921:
3893:
3856:
3818:Other globulins
3809:
3769:
3765:Immunoglobulins
3747:
3709:
3704:
3701:
3682:
3664:
3638:
3633:
3603:
3598:
3553:
3545:Alpha globulins
3527:
3522:
3492:
3487:
3448:Adaptor protein
3431:
3388:
3345:
3288:
3261:steroid hormone
3186:peptide hormone
3174:
3126:
3117:
3087:
3082:
3079:
3073:
3064:
3058:
3044:
3041:
2978:
2973:
2688:(10): 3257–61.
2653:(18): 10780–5.
2466:(12): 5377–81.
2370:
2368:Further reading
2365:
2318:
2314:
2285:(1–3): 167–71.
2275:
2271:
2226:
2222:
2182:
2178:
2141:
2137:
2100:
2096:
2067:(3018): 484–5.
2057:
2053:
2044:
2042:
2040:medlineplus.gov
2034:
2033:
2029:
1992:
1988:
1943:
1939:
1932:
1918:
1909:
1862:
1858:
1827:
1823:
1816:
1800:
1796:
1775:Acta Chem Scand
1767:
1763:
1724:
1720:
1679:(14): 5086–90.
1662:
1658:
1603:
1599:
1586:
1585:
1581:
1568:
1567:
1563:
1551:
1542:
1530:
1521:
1517:
1498:
1438:zinc deficiency
1434:copper toxicity
1427:
1389:
1265:
1248:
1232:
1207:
1153:
1141:iron metabolism
1100:View/Edit Mouse
1095:View/Edit Human
1058:
1051:
1048:Location (UCSC)
1034:
1030:
1026:
1022:
1001:
975:
971:
967:
963:
959:
938:
851:ENSG00000047457
744:
698:
694:plasma membrane
652:
588:
557:
548:
543:
539:
537:right lung lobe
535:
531:
527:
523:
519:
515:
511:
497:
486:
483:tibial arteries
481:
477:
475:ascending aorta
473:
469:
465:
461:
457:
453:
449:
435:
379:
366:
358:
348:
347:
346:
339:
319:
296:Gene location (
278:
265:
257:
247:
246:
245:
238:
216:
193:Gene location (
180:
130:
117:
110:
75:
53:
17:
12:
11:
5:
5242:
5232:
5231:
5229:Copper enzymes
5226:
5221:
5216:
5211:
5206:
5201:
5186:
5185:
5162:
5161:
5159:
5158:
5145:
5132:
5119:
5106:
5093:
5080:
5066:
5064:
5060:
5059:
5057:
5056:
5051:
5046:
5041:
5036:
5030:
5028:
5024:
5023:
5021:
5020:
5015:
5010:
5005:
4999:
4997:
4996:Classification
4993:
4992:
4990:
4989:
4984:
4979:
4974:
4968:
4966:
4962:
4961:
4959:
4958:
4953:
4948:
4943:
4938:
4933:
4928:
4923:
4917:
4915:
4911:
4910:
4903:
4902:
4895:
4888:
4880:
4871:
4870:
4868:
4867:
4862:
4857:
4852:
4847:
4846:
4845:
4840:
4832:
4827:
4822:
4816:
4814:
4807:
4806:
4804:
4803:
4802:
4801:
4796:
4791:
4786:
4775:
4773:
4758:
4757:
4755:
4754:
4748:
4746:
4735:
4734:
4732:
4731:
4725:
4723:
4712:
4711:
4709:
4708:
4703:
4698:
4693:
4687:
4685:
4678:
4677:
4675:
4674:
4669:
4663:
4661:
4650:
4649:
4647:
4646:
4645:
4644:
4639:
4634:
4623:
4621:
4610:
4609:
4596:
4595:
4588:
4581:
4573:
4564:
4563:
4560:
4559:
4557:
4556:
4551:
4545:
4543:
4537:
4536:
4534:
4533:
4527:
4525:
4519:
4518:
4516:
4515:
4509:
4507:
4501:
4500:
4498:
4497:
4491:
4489:
4480:
4474:
4473:
4470:
4469:
4467:
4466:
4461:
4456:
4451:
4445:
4443:
4437:
4436:
4434:
4433:
4428:
4423:
4418:
4413:
4407:
4405:
4399:
4398:
4395:
4394:
4391:
4390:
4388:
4387:
4382:
4377:
4372:
4367:
4366:
4365:
4355:
4350:
4340:
4337:
4336:
4334:
4333:
4327:
4325:
4315:
4311:
4310:
4307:
4306:
4304:
4303:
4298:
4293:
4288:
4282:
4280:
4273:
4272:
4270:
4269:
4268:
4267:
4262:
4248:
4239:
4234:
4232:DMT1 (SLC11A2)
4228:
4226:
4223:Iron(II) oxide
4216:
4205:
4196:
4190:
4189:
4178:
4177:
4170:
4163:
4155:
4146:
4145:
4143:
4142:
4137:
4131:
4129:
4125:
4124:
4122:
4121:
4116:
4111:
4106:
4101:
4096:
4091:
4086:
4081:
4076:
4071:
4066:
4060:
4058:
4057:Other positive
4054:
4053:
4051:
4050:
4045:
4039:
4037:
4031:
4030:
4023:
4022:
4015:
4008:
4000:
3991:
3990:
3987:
3986:
3977:
3976:
3973:
3972:
3969:
3968:
3966:
3965:
3960:
3955:
3950:
3945:
3935:
3929:
3927:
3923:
3922:
3920:
3919:
3914:
3909:
3903:
3901:
3895:
3894:
3892:
3891:
3886:
3881:
3875:
3873:
3864:
3858:
3857:
3855:
3854:
3849:
3844:
3839:
3834:
3833:
3832:
3821:
3819:
3815:
3814:
3811:
3810:
3808:
3807:
3802:
3800:Transcobalamin
3797:
3788:
3777:
3775:
3771:
3770:
3768:
3767:
3761:
3759:
3757:Gamma globulin
3753:
3752:
3749:
3748:
3746:
3745:
3740:
3735:
3730:
3725:
3720:
3714:
3712:
3706:
3705:
3703:
3702:
3696:
3690:
3688:
3676:
3674:Beta globulins
3670:
3669:
3666:
3665:
3663:
3662:
3651:
3643:
3641:
3635:
3634:
3632:
3631:
3626:
3619:
3611:
3609:
3600:
3599:
3597:
3596:
3586:
3576:
3561:
3559:
3547:
3538:
3529:
3528:
3521:
3520:
3513:
3506:
3498:
3489:
3488:
3486:
3485:
3480:
3475:
3470:
3465:
3460:
3455:
3450:
3445:
3439:
3437:
3433:
3432:
3430:
3429:
3424:
3419:
3414:
3409:
3404:
3398:
3396:
3390:
3389:
3387:
3386:
3384:Transcobalamin
3381:
3380:
3379:
3374:
3369:
3364:
3353:
3351:
3347:
3346:
3344:
3343:
3342:
3341:
3336:
3326:
3325:
3324:
3314:
3313:
3312:
3307:
3296:
3294:
3290:
3289:
3287:
3286:
3281:
3276:
3271:
3257:
3256:
3255:
3254:
3249:
3239:
3238:
3237:
3232:
3227:
3222:
3217:
3212:
3207:
3197:
3192:
3182:
3180:
3176:
3175:
3173:
3172:
3167:
3162:
3157:
3152:
3147:
3142:
3136:
3134:
3128:
3127:
3116:
3115:
3108:
3101:
3093:
3084:
3083:
3081:
3080:
3074:
3067:
3065:
3059:
3052:
3049:
3046:
3045:
3040:
3039:
3032:
3025:
3017:
3011:
3010:
2989:
2984:
2977:
2976:External links
2974:
2972:
2971:
2951:(7): 2878–85.
2936:
2883:
2830:
2793:
2763:
2726:
2673:
2638:
2618:(13): 7701–7.
2603:
2568:
2525:
2504:
2451:
2441:(2): RA48-51.
2430:
2401:
2371:
2369:
2366:
2364:
2363:
2312:
2269:
2220:
2176:
2149:Anesthesiology
2135:
2094:
2051:
2027:
1986:
1957:(5): 1509–19.
1937:
1930:
1907:
1856:
1821:
1814:
1794:
1761:
1718:
1656:
1597:
1579:
1561:
1540:
1518:
1516:
1513:
1497:
1494:
1493:
1492:
1487:
1482:
1477:
1472:
1467:
1456:
1451:
1445:
1440:
1426:
1423:
1422:
1421:
1416:
1411:
1405:
1402:Menkes disease
1399:
1396:Wilson disease
1388:
1385:
1367:, progressive
1335:
1334:
1325:due to absent
1311:
1304:Menkes disease
1296:
1295:
1294:
1288:
1279:
1264:
1261:
1247:
1244:
1230:
1206:
1203:
1199:person's urine
1181:export of iron
1152:
1149:
1116:caeruloplasmin
1107:
1106:
1103:
1102:
1097:
1087:
1086:
1080:
1079:
1076:
1075:
1073:
1071:
1064:
1063:
1056:
1049:
1045:
1044:
1041:
1040:
1018:
1017:
1011:
1008:
1007:
997:
996:
990:
986:
985:
982:
981:
955:
954:
948:
945:
944:
934:
933:
927:
923:
922:
919:
918:
910:
909:
903:
900:
899:
891:
890:
884:
878:
877:
874:
873:
865:
864:
858:
855:
854:
846:
845:
839:
833:
832:
829:
828:
820:
819:
813:
810:
809:
801:
800:
794:
788:
787:
782:
777:
773:
772:
762:
761:
758:
757:
746:
745:
743:
742:
737:
732:
727:
722:
717:
712:
706:
704:
700:
699:
697:
696:
691:
686:
681:
676:
671:
666:
660:
658:
654:
653:
651:
650:
645:
640:
635:
630:
625:
619:
617:
613:
612:
602:
601:
598:
597:
594:
593:
585:
584:
573:
567:
566:
563:
562:
554:
553:
550:
549:
547:
546:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
503:
502:
491:
488:
487:
485:
484:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
441:
440:
428:
427:
419:
408:
402:
401:
398:RNA expression
390:
389:
386:
385:
377:
373:
372:
364:
361:
356:
350:
349:
340:
333:
327:
323:
322:
317:
311:
310:
302:
301:
289:
288:
285:
284:
276:
272:
271:
263:
260:
255:
249:
248:
239:
232:
226:
222:
221:
214:
208:
207:
199:
198:
186:
185:
178:
172:
171:
168:CP - orthologs
128:
124:
123:
115:
107:
106:
102:
101:
98:
97:
94:
93:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
5241:
5230:
5227:
5225:
5222:
5220:
5217:
5215:
5212:
5210:
5207:
5205:
5202:
5200:
5197:
5196:
5194:
5184:
5179:
5174:
5173:
5170:
5156:
5152:
5151:
5146:
5143:
5139:
5138:
5133:
5130:
5126:
5125:
5120:
5117:
5113:
5112:
5107:
5104:
5100:
5099:
5094:
5091:
5087:
5086:
5081:
5078:
5074:
5073:
5068:
5067:
5065:
5061:
5055:
5052:
5050:
5047:
5045:
5042:
5040:
5037:
5035:
5032:
5031:
5029:
5025:
5019:
5016:
5014:
5013:Enzyme family
5011:
5009:
5006:
5004:
5001:
5000:
4998:
4994:
4988:
4985:
4983:
4980:
4978:
4977:Cooperativity
4975:
4973:
4970:
4969:
4967:
4963:
4957:
4954:
4952:
4949:
4947:
4944:
4942:
4939:
4937:
4936:Oxyanion hole
4934:
4932:
4929:
4927:
4924:
4922:
4919:
4918:
4916:
4912:
4908:
4901:
4896:
4894:
4889:
4887:
4882:
4881:
4878:
4866:
4863:
4861:
4858:
4856:
4853:
4851:
4848:
4844:
4841:
4839:
4836:
4835:
4833:
4831:
4828:
4826:
4823:
4821:
4818:
4817:
4815:
4812:
4808:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4781:
4780:
4777:
4776:
4774:
4771:
4767:
4763:
4759:
4753:
4750:
4749:
4747:
4744:
4740:
4736:
4730:
4727:
4726:
4724:
4721:
4717:
4713:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4688:
4686:
4683:
4679:
4673:
4670:
4668:
4667:Ceruloplasmin
4665:
4664:
4662:
4659:
4655:
4651:
4643:
4640:
4638:
4635:
4633:
4630:
4629:
4628:
4625:
4624:
4622:
4619:
4615:
4611:
4606:
4602:
4594:
4589:
4587:
4582:
4580:
4575:
4574:
4571:
4555:
4552:
4550:
4547:
4546:
4544:
4542:
4538:
4532:
4529:
4528:
4526:
4524:
4520:
4514:
4511:
4510:
4508:
4506:
4502:
4496:
4493:
4492:
4490:
4488:
4484:
4481:
4479:
4475:
4465:
4462:
4460:
4457:
4455:
4452:
4450:
4447:
4446:
4444:
4442:
4438:
4432:
4429:
4427:
4424:
4422:
4421:Ceruloplasmin
4419:
4417:
4414:
4412:
4409:
4408:
4406:
4404:
4400:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4370:Ceruloplasmin
4368:
4364:
4361:
4360:
4359:
4356:
4354:
4351:
4349:
4345:
4342:
4341:
4338:
4332:
4329:
4328:
4326:
4323:
4319:
4316:
4312:
4302:
4299:
4297:
4294:
4292:
4289:
4287:
4284:
4283:
4281:
4278:
4274:
4266:
4263:
4261:
4258:
4257:
4256:
4252:
4249:
4247:
4243:
4240:
4238:
4235:
4233:
4230:
4229:
4227:
4224:
4220:
4217:
4215:
4212:Absorption in
4209:
4206:
4204:
4200:
4197:
4195:
4191:
4187:
4183:
4176:
4171:
4169:
4164:
4162:
4157:
4156:
4153:
4141:
4138:
4136:
4135:Serum albumin
4133:
4132:
4130:
4126:
4120:
4117:
4115:
4112:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4084:Ceruloplasmin
4082:
4080:
4077:
4075:
4072:
4070:
4067:
4065:
4062:
4061:
4059:
4055:
4049:
4046:
4044:
4041:
4040:
4038:
4036:
4032:
4028:
4021:
4016:
4014:
4009:
4007:
4002:
4001:
3998:
3985:
3982:
3979:
3978:
3974:
3964:
3961:
3959:
3956:
3954:
3951:
3949:
3946:
3943:
3939:
3936:
3934:
3931:
3930:
3928:
3924:
3918:
3915:
3913:
3910:
3908:
3905:
3904:
3902:
3900:
3899:Serum albumin
3896:
3890:
3887:
3885:
3882:
3880:
3877:
3876:
3874:
3872:
3868:
3865:
3863:
3859:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3837:Thyroglobulin
3835:
3831:
3828:
3827:
3826:
3823:
3822:
3820:
3816:
3806:
3803:
3801:
3798:
3796:
3795:Microglobulin
3792:
3791:Macroglobulin
3789:
3786:
3782:
3779:
3778:
3776:
3772:
3766:
3763:
3762:
3760:
3758:
3754:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3715:
3713:
3707:
3700:
3697:
3695:
3692:
3691:
3689:
3685:
3680:
3677:
3675:
3671:
3660:
3656:
3652:
3649:
3645:
3644:
3642:
3636:
3630:
3627:
3624:
3623:Ceruloplasmin
3620:
3617:
3613:
3612:
3610:
3606:
3601:
3594:
3590:
3587:
3584:
3580:
3577:
3574:
3570:
3566:
3563:
3562:
3560:
3556:
3551:
3548:
3546:
3542:
3539:
3537:
3534:
3530:
3526:
3519:
3514:
3512:
3507:
3505:
3500:
3499:
3496:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
3458:F-box protein
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3440:
3438:
3434:
3428:
3425:
3423:
3420:
3418:
3415:
3413:
3410:
3408:
3405:
3403:
3400:
3399:
3397:
3395:
3391:
3385:
3382:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3359:
3358:
3355:
3354:
3352:
3348:
3340:
3337:
3335:
3332:
3331:
3330:
3327:
3323:
3322:Ceruloplasmin
3320:
3319:
3318:
3315:
3311:
3308:
3306:
3303:
3302:
3301:
3298:
3297:
3295:
3293:Metal/element
3291:
3285:
3284:Transthyretin
3282:
3280:
3277:
3275:
3272:
3270:
3266:
3262:
3259:
3258:
3253:
3250:
3248:
3247:Neurophysin I
3245:
3244:
3243:
3240:
3236:
3233:
3231:
3228:
3226:
3223:
3221:
3218:
3216:
3213:
3211:
3208:
3206:
3203:
3202:
3201:
3198:
3196:
3193:
3191:
3187:
3184:
3183:
3181:
3177:
3171:
3168:
3166:
3163:
3161:
3158:
3156:
3153:
3151:
3148:
3146:
3143:
3141:
3138:
3137:
3135:
3133:
3129:
3125:
3121:
3114:
3109:
3107:
3102:
3100:
3095:
3094:
3091:
3077:
3071:
3066:
3062:
3056:
3051:
3050:
3047:
3038:
3033:
3031:
3026:
3024:
3019:
3018:
3015:
3008:
3004:
3003:
2998:
2994:
2990:
2988:
2985:
2983:
2980:
2979:
2968:
2964:
2959:
2954:
2950:
2946:
2942:
2937:
2933:
2929:
2924:
2919:
2914:
2909:
2905:
2901:
2897:
2893:
2889:
2884:
2880:
2876:
2871:
2866:
2861:
2856:
2852:
2848:
2844:
2840:
2836:
2831:
2827:
2823:
2819:
2815:
2811:
2807:
2804:(5): 867–70.
2803:
2799:
2794:
2790:
2786:
2782:
2778:
2775:(1): 91–102.
2774:
2770:
2764:
2760:
2756:
2752:
2748:
2744:
2740:
2737:(2): 185–90.
2736:
2732:
2727:
2723:
2719:
2714:
2709:
2704:
2699:
2695:
2691:
2687:
2683:
2679:
2674:
2670:
2666:
2661:
2656:
2652:
2648:
2644:
2639:
2635:
2631:
2626:
2621:
2617:
2613:
2609:
2604:
2600:
2596:
2591:
2586:
2583:(4): 1834–6.
2582:
2578:
2574:
2569:
2565:
2561:
2556:
2551:
2547:
2543:
2540:(2): 657–61.
2539:
2535:
2531:
2526:
2522:
2518:
2514:
2510:
2505:
2501:
2497:
2492:
2487:
2482:
2477:
2473:
2469:
2465:
2461:
2457:
2452:
2448:
2444:
2440:
2436:
2431:
2427:
2423:
2419:
2415:
2411:
2407:
2402:
2398:
2394:
2390:
2386:
2382:
2378:
2373:
2372:
2359:
2355:
2350:
2345:
2340:
2335:
2331:
2327:
2323:
2316:
2308:
2304:
2300:
2296:
2292:
2288:
2284:
2280:
2273:
2265:
2261:
2256:
2251:
2247:
2243:
2239:
2235:
2231:
2224:
2216:
2212:
2208:
2204:
2200:
2196:
2192:
2188:
2180:
2172:
2168:
2163:
2158:
2154:
2150:
2146:
2139:
2131:
2127:
2122:
2117:
2113:
2109:
2105:
2098:
2090:
2086:
2082:
2078:
2074:
2070:
2066:
2062:
2055:
2041:
2037:
2031:
2023:
2019:
2014:
2009:
2006:(2): 167–72.
2005:
2001:
1997:
1990:
1982:
1978:
1973:
1968:
1964:
1960:
1956:
1952:
1948:
1941:
1933:
1927:
1923:
1916:
1914:
1912:
1903:
1899:
1894:
1889:
1884:
1879:
1875:
1871:
1867:
1860:
1852:
1848:
1844:
1840:
1836:
1832:
1825:
1817:
1811:
1807:
1806:
1798:
1789:
1784:
1780:
1776:
1772:
1765:
1757:
1753:
1749:
1745:
1741:
1737:
1734:(3): 285–92.
1733:
1729:
1722:
1714:
1710:
1705:
1700:
1695:
1690:
1686:
1682:
1678:
1674:
1670:
1666:
1665:Koschinsky ML
1660:
1652:
1648:
1643:
1638:
1633:
1628:
1624:
1620:
1616:
1612:
1608:
1601:
1593:
1589:
1583:
1575:
1571:
1565:
1558:
1554:
1549:
1547:
1545:
1537:
1533:
1528:
1526:
1524:
1519:
1509:
1505:
1501:
1491:
1488:
1486:
1485:Schizophrenia
1483:
1481:
1478:
1476:
1473:
1471:
1468:
1465:
1461:
1457:
1455:
1452:
1449:
1446:
1444:
1441:
1439:
1435:
1432:
1431:
1430:
1420:
1419:Zinc toxicity
1417:
1415:
1412:
1409:
1406:
1403:
1400:
1397:
1394:
1393:
1392:
1384:
1382:
1378:
1374:
1370:
1366:
1362:
1361:iron overload
1358:
1354:
1349:
1347:
1342:
1340:
1332:
1328:
1324:
1320:
1316:
1312:
1309:
1305:
1301:
1297:
1292:
1291:Zinc toxicity
1289:
1286:
1283:
1282:
1280:
1277:
1273:
1272:
1271:
1268:
1260:
1257:
1253:
1238:
1234:
1228:
1224:
1220:
1216:
1212:
1202:
1200:
1195:
1193:
1192:iron overload
1188:
1186:
1182:
1176:
1174:
1169:
1165:
1162:
1158:
1148:
1146:
1142:
1138:
1133:
1131:
1128:
1124:
1121:
1117:
1113:
1112:Ceruloplasmin
1101:
1096:
1092:
1088:
1085:
1081:
1074:
1072:
1069:
1065:
1061:
1057:
1054:
1050:
1046:
1039:
1037:
1033:
1029:
1025:
1019:
1015:
1012:
1006:
1004:
998:
994:
991:
987:
980:
978:
974:
970:
966:
962:
956:
952:
949:
943:
941:
935:
931:
928:
926:RefSeq (mRNA)
924:
917:
916:
911:
907:
904:
898:
897:
892:
888:
885:
883:
879:
872:
871:
866:
862:
859:
853:
852:
847:
843:
840:
838:
834:
827:
826:
821:
817:
814:
808:
807:
802:
798:
795:
793:
789:
786:
783:
781:
778:
774:
771:
767:
763:
756:
752:
747:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
710:ion transport
708:
707:
705:
702:
701:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
665:
662:
661:
659:
656:
655:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
620:
618:
615:
614:
611:
610:Gene ontology
607:
603:
591:
586:
582:
577:
574:
572:
568:
560:
555:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
507:
504:
500:
495:
492:
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
445:
442:
438:
433:
430:
429:
426:
424:
420:
418:
417:
413:
412:
409:
407:
403:
399:
395:
391:
383:
378:
374:
370:
365:
355:
351:
344:
337:
331:
324:
316:
312:
308:
303:
299:
294:
290:
282:
277:
273:
269:
264:
254:
250:
243:
236:
230:
223:
219:
213:
209:
205:
200:
196:
191:
187:
183:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
125:
120:
113:
108:
103:
92:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
5150:Translocases
5147:
5134:
5121:
5108:
5095:
5085:Transferases
5082:
5069:
4926:Binding site
4779:Glutaredoxin
4764:: Acting on
4718:: Acting on
4666:
4656:: Oxidizing
4616:: Acting on
4420:
4369:
4083:
3980:
3622:
3589:Antithrombin
3328:
3321:
3316:
3299:
3242:Neurophysins
3075:
3060:
3000:
2948:
2944:
2898:(2): 790–4.
2895:
2891:
2845:(1): 115–9.
2842:
2838:
2801:
2797:
2772:
2768:
2734:
2731:FEBS Letters
2730:
2685:
2681:
2650:
2646:
2615:
2611:
2580:
2576:
2537:
2533:
2515:(2): 154–9.
2512:
2508:
2463:
2459:
2438:
2434:
2409:
2405:
2380:
2376:
2329:
2325:
2315:
2282:
2278:
2272:
2240:(1): 22–32.
2237:
2233:
2223:
2190:
2186:
2179:
2155:(4): 764–5.
2152:
2148:
2138:
2114:(3): 271–6.
2111:
2107:
2097:
2064:
2060:
2054:
2043:. Retrieved
2039:
2030:
2003:
1999:
1989:
1954:
1950:
1940:
1921:
1873:
1869:
1859:
1834:
1830:
1824:
1804:
1797:
1778:
1774:
1764:
1731:
1727:
1721:
1676:
1672:
1659:
1617:(2): 390–4.
1614:
1610:
1600:
1591:
1582:
1573:
1564:
1499:
1460:inflammation
1428:
1390:
1352:
1350:
1346:immunoassays
1343:
1336:
1302:deficiency (
1285:Malnutrition
1269:
1266:
1256:GAIT element
1249:
1208:
1196:
1189:
1177:
1154:
1134:
1126:
1115:
1111:
1110:
1036:NP_001361606
1028:NP_001263179
1024:NP_001263177
1021:
1000:
977:NM_001374677
969:NM_001276250
965:NM_001276248
961:NM_001042611
958:
937:
913:
894:
868:
849:
823:
804:
784:
779:
521:carotid body
517:ciliary body
421:
414:
279:149,221,829
266:149,162,410
127:External IDs
74:
18:
4921:Active site
4729:Nitrogenase
4620:as acceptor
4495:Na/K-ATPase
4478:Electrolyte
4385:Lactoferrin
4380:Hemosiderin
4353:Hemojuvelin
4251:Transferrin
4140:Transferrin
4119:Orosomucoid
4104:Haptoglobin
3948:Parvalbumin
3938:Lactalbumin
3830:Lactoferrin
3781:Fibronectin
3738:Plasminogen
3718:Angiostatin
3699:Transferrin
3659:Haptoglobin
3648:Orosomucoid
3616:Transcortin
3422:Phytochrome
3274:Transcortin
3190:Follistatin
3043:PDB gallery
2412:(2): 91–8.
2193:(1): 50–9.
1323:hepatocytes
1254:called the
1185:transferrin
1173:transferrin
1120:ferroxidase
545:gallbladder
380:20,063,309
367:20,011,218
359:3|3 A2
105:Identifiers
5219:Hepatology
5193:Categories
5124:Isomerases
5098:Hydrolases
4965:Regulation
4766:phosphorus
4743:flavodoxin
4618:superoxide
4607:1.15–1.21)
4242:Hephaestin
4182:Metabolism
3917:Prealbumin
3879:Conalbumin
3132:Fatty acid
2798:Hepatology
2383:: 439–58.
2045:2021-12-10
1837:: 439–58.
1781:: 550–56.
1559:, May 2017
1538:, May 2017
1515:References
1462:(it is an
1410:deficiency
1387:Deficiency
1339:hepatocyte
1246:Regulation
1145:hephaestin
425:(ortholog)
258:3q24-q25.1
148:HomoloGene
5214:EC 1.16.3
5003:EC number
4772:in donors
4722:as donors
4363:Aconitase
4114:Hemopexin
3884:Ovalbumin
3871:Egg white
3743:Properdin
3723:Hemopexin
3653:alpha-2 (
3646:alpha-1 (
3621:alpha-2 (
3614:alpha-1 (
3536:globulins
3427:Rhodopsin
2187:Angiology
1443:pregnancy
1381:endocrine
1377:cirrhosis
1223:histidine
1032:NP_031778
1003:NP_000087
973:NM_007752
940:NM_000096
770:Orthologs
730:transport
541:left lung
176:EC number
156:GeneCards
5027:Kinetics
4951:Cofactor
4914:Activity
4745:as donor
4344:Hepcidin
4331:Ferritin
4301:Ferritin
4291:Integrin
4237:Ferritin
4214:duodenum
4128:Negative
4094:Ferritin
3981:see also
3862:Albumins
3733:Factor H
3120:Proteins
2826:43824397
2759:23472934
2447:15668644
2426:12575997
2397:12055353
2358:19017404
2307:38267889
2299:16842975
2264:18534184
2207:18388036
2171:18362615
2089:12994898
2022:16267389
1981:12588972
1902:23825457
1851:12055353
1756:45686258
1555:–
1534:–
1454:lymphoma
1369:dementia
1215:type III
1164:1.16.3.1
1151:Function
1084:Wikidata
749:Sources:
182:1.16.3.1
5183:Biology
5137:Ligases
4907:Enzymes
4770:arsenic
4464:SLC39A4
4459:SLC30A1
4426:SLC31A1
4035:Amyloid
3805:Edestin
3579:alpha-2
3565:alpha-1
3555:serpins
3394:Pigment
3350:Vitamin
3300:calcium
3179:Hormone
3007:PDBe-KB
2997:UniProt
2967:6987229
2932:6940148
2900:Bibcode
2879:6571985
2847:Bibcode
2818:6479854
2789:6337857
2751:3755405
2722:3486416
2690:Bibcode
2669:2355023
2634:2332446
2599:2105310
2564:1463466
2555:1132061
2468:Bibcode
2349:2596773
2255:2556376
2130:9727700
2069:Bibcode
2061:Science
1893:3695389
1748:3474786
1713:2873574
1681:Bibcode
1651:6582496
1619:Bibcode
1557:Ensembl
1536:Ensembl
1241:yellow.
1219:type II
1118:) is a
882:UniProt
837:Ensembl
776:Species
755:QuickGO
400:pattern
112:Aliases
5169:Portal
5111:Lyases
4599:Other
4099:Fibrin
3889:Avidin
3783:(fFN:
3710:other:
3639:other:
3317:copper
3235:IGFBP7
3230:IGFBP6
3225:IGFBP5
3220:IGFBP4
3215:IGFBP3
3210:IGFBP2
3205:IGFBP1
3002:P00450
2965:
2930:
2923:319888
2920:
2877:
2870:393320
2867:
2824:
2816:
2787:
2757:
2749:
2720:
2713:323492
2710:
2667:
2632:
2597:
2562:
2552:
2521:463490
2519:
2500:146197
2498:
2491:431726
2488:
2445:
2424:
2395:
2356:
2346:
2332:: 52.
2305:
2297:
2262:
2252:
2215:843454
2213:
2205:
2169:
2128:
2087:
2020:
1979:
1972:151701
1969:
1928:
1900:
1890:
1876:: 24.
1849:
1812:
1754:
1746:
1711:
1704:323895
1701:
1649:
1642:344682
1639:
1475:Angina
1425:Excess
1408:Copper
1371:, and
1365:ataxia
1211:type I
1168:copper
1157:enzyme
1137:copper
1123:enzyme
1070:search
1068:PubMed
915:Q61147
896:P00450
792:Entrez
571:BioGPS
136:117700
5063:Types
4799:GLRX5
4794:GLRX3
4789:GLRX2
4658:metal
4431:ATOX1
4416:ATP7B
4411:ATP7A
4314:Other
3953:Ricin
3926:Other
3774:Other
3533:Serum
3436:Other
3170:FABP7
3165:FABP6
3160:FABP5
3155:FABP4
3150:FABP3
3145:FABP2
3140:FABP1
2822:S2CID
2755:S2CID
2303:S2CID
2211:S2CID
1752:S2CID
1327:ATP7B
1319:Golgi
1300:ATP7A
825:12870
785:Mouse
780:Human
751:Amigo
423:Mouse
416:Human
363:Start
298:Mouse
262:Start
195:Human
144:88476
5155:list
5148:EC7
5142:list
5135:EC6
5129:list
5122:EC5
5116:list
5109:EC4
5103:list
5096:EC3
5090:list
5083:EC2
5077:list
5070:EC1
4811:1.21
4784:GLRX
4762:1.20
4739:1.19
4716:1.18
4682:1.17
4660:ions
4654:1.16
4642:SOD3
4637:SOD2
4632:SOD1
4614:1.15
4454:TMC8
4449:TMC6
4348:HAMP
4265:TFR2
4260:TFR1
3329:iron
3076:2j5w
3061:1kcw
2995:for
2963:PMID
2928:PMID
2875:PMID
2814:PMID
2785:PMID
2747:PMID
2718:PMID
2665:PMID
2630:PMID
2595:PMID
2560:PMID
2517:PMID
2496:PMID
2443:PMID
2422:PMID
2393:PMID
2354:PMID
2295:PMID
2260:PMID
2203:PMID
2167:PMID
2126:PMID
2085:PMID
2018:PMID
1977:PMID
1926:ISBN
1898:PMID
1847:PMID
1810:ISBN
1744:PMID
1709:PMID
1647:PMID
1306:and
1130:gene
1114:(or
806:1356
406:Bgee
354:Band
315:Chr.
253:Band
212:Chr.
132:OMIM
89:4ENZ
85:4EJX
81:2J5W
77:1KCW
58:RCSB
55:PDBe
4768:or
4375:HFE
4253:to
4048:SAA
4043:SAP
2993:PDB
2953:doi
2949:255
2918:PMC
2908:doi
2865:PMC
2855:doi
2806:doi
2777:doi
2773:143
2739:doi
2735:203
2708:PMC
2698:doi
2655:doi
2651:265
2620:doi
2616:265
2585:doi
2581:265
2550:PMC
2542:doi
2538:288
2486:PMC
2476:doi
2414:doi
2385:doi
2344:PMC
2334:doi
2287:doi
2250:PMC
2242:doi
2238:476
2195:doi
2157:doi
2153:108
2116:doi
2077:doi
2065:116
2008:doi
1967:PMC
1959:doi
1888:PMC
1878:doi
1839:doi
1783:doi
1736:doi
1699:PMC
1689:doi
1637:PMC
1627:doi
1450:use
1227:Cys
376:End
275:End
164:OMA
140:MGI
48:PDB
5195::
4605:EC
4184::
4089:C3
3657:,
3571:,
3263::
3252:II
3188::
3122::
2999::
2961:.
2947:.
2943:.
2926:.
2916:.
2906:.
2896:78
2894:.
2890:.
2873:.
2863:.
2853:.
2843:80
2841:.
2837:.
2820:.
2812:.
2800:.
2783:.
2771:.
2753:.
2745:.
2733:.
2716:.
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2663:.
2649:.
2645:.
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2420:.
2410:28
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2391:.
2381:22
2379:.
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2328:.
2324:.
2301:.
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2112:44
2110:.
2106:.
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2016:.
2004:20
2002:.
1998:.
1975:.
1965:.
1955:23
1953:.
1949:.
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1896:.
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1773:.
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1707:.
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1635:.
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1613:.
1609:.
1590:.
1572:.
1543:^
1522:^
1436:/
1379:,
1353:CP
1315:ER
1250:A
1194:.
1187:.
1161:EC
1132:.
1127:CP
753:/
382:bp
369:bp
281:bp
268:bp
162:;
160:CP
158::
154:;
152:75
150::
146:;
142::
138:;
134::
119:CP
87:,
83:,
79:,
24:CP
5171::
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5153:(
5144:)
5140:(
5131:)
5127:(
5118:)
5114:(
5105:)
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