159:. There are multiple classes of cadherin molecules, each designated with a prefix for tissues with which it associates. Classical cadherins maintain the tone of tissues by forming a homodimer in cis while desmosomal cadherins are heterodimeric. The intracellular portion of classical cadherins interacts with a complex of proteins that allows connection to the actin cytoskeleton. Although classical cadherins take a role in cell layer formation and structure formation, desmosomal cadherins focus on resisting cell damage. Desmosomal cadherins maintain the function of desmosomes that is to overturn the mechanical stress of the tissues. Similar to classical cadherins, desmosomal cadherins have a single transmembrane domain, five EC repeats, and an intracellular domain. There are two types of desmosomal cadherins: desmogleins and desmocollins. These contain an intracellular anchor and cadherin like sequence (ICS). The adaptor proteins that associate with desmosomal cadherins are plakoglobin (related to
382:, especially in sorting out of the precardiac mesoderm. N-cadherins are robustly expressed in precardiac mesoderm, but they do not take a role in cardiac linage. An embryo with N-cadherin mutation still forms the primitive heart tube; however, N-cadherin deficient mice will have difficulties in maintaining the cardiomyocytes development. The myocytes of these mice will end up with dissociated myocytes surrounding the endocardial cell layer when they cannot preserve the cell adhesion due to the heart starting to pump. As a result, the cardiac outflow tract will be blocked causing cardiac swelling. The expression of different types of cadherins in the cells varies dependent upon the specific differentiation and specification of an organism during development. Cadherins play a vital role in the migration of cells through the
33:
386:, which requires cadherins to form adherents junctions with neighboring cells. In neural crest cells, which are transient cells that arise in the developing organism during gastrulation and function in the patterning of the vertebrate body plan, the cadherins are necessary to allow migration of cells to form tissues or organs. In addition, cadherins that are responsible in the epithelial–mesenchymal transition event in early development have also been shown to be critical in the reprogramming of specified adult cells into a pluripotent state, forming
460:
204:
86:
327:-catenin is engaged by p120-catenin complex, where vinculin is recruited to take a role in indirect association with actin cytoskeleton. However, cadherin-catenin complex can also bind directly to the actin without the help of vinculin. Moreover, the strength of cadherin adhesion can increase by dephosphorylation of p120 catenin and the binding of
416:
form bridges. The loss of the cell adhesion molecules, E cadherins, is causally involved in the formation of epithelial types of cancers such as carcinomas. The changes in any types of cadherin expression may not only control tumor cell adhesion but also may affect signal transduction leading to the cancer cells growing uncontrollably.
649:
There are said to be over 100 different types of cadherins found in vertebrates, which can be classified into four groups: classical, desmosomal, protocadherins, and unconventional. These large amount of diversities are accomplished by having multiple cadherin encoding genes combined with alternative
441:
This family of glycoproteins is responsible for calcium-dependent mechanism of intracellular adhesion. E-cadherins are crucial in embryogenesis during several processes, including gastrulation, neurulation, and organogenesis. Furthermore, suppression of E-cadherins impairs intracellular adhesion. The
373:
forms in an embryo, the tissues residing near the cranial neural folds have decreased N-cadherin expression. Conversely, the expression of the N-cadherins remains unchanged in other regions of the neural tube that is located on the anterior-posterior axis of the vertebrate. N-cadherins have different
428:
such as the cadherin glycoproteins that normally function as the glue and holds cells together act as important mediators of cell to cell interactions. E-cadherins, on the surface of all epithelial cells, are linked to the actin cytoskeleton through interactions with catenins in the cytoplasm. Thus,
194:
tend to cluster with other N-cadherin-expressing cells. However, mixing speed in cell culture experiments can effect the extent of homotypic specificity. In addition, several groups have observed heterotypic binding affinity (i.e., binding of different types of cadherin together) in various assays.
36:
Principal interactions of structural proteins at cadherin-based adherens junction. Actin filaments are linked to α-actinin and to the membrane through vinculin. The head domain of vinculin is associated with E-cadherin via α-, β-, and γ-catenins. The tail domain of vinculin binds to membrane lipids
415:
It has been discovered that cadherins and other additional factors are correlated to the formation and growth of some cancers and how a tumor continues to grow. The E-cadherins, known as the epithelial cadherins, are on the surface of one cell and can bind with those of the same kind on another to
402:
The E-cadherin–catenin complex plays a key role in cellular adhesion; loss of this function has been associated with increased invasiveness and metastasis of tumors. The suppression of E-cadherin expression is regarded as one of the main molecular events responsible for dysfunction in cell-cell
211:
Cadherins are synthesized as polypeptides and undergo many post-translational modifications to become the proteins which mediate cell-cell adhesion and recognition. These polypeptides are approximately 720–750 amino acids long. Each cadherin has a small C-terminal cytoplasmic component, a
429:
anchored to the cytoskeleton, E-cadherins on the surface of one cell can bind with those on another to form bridges. In epithelial cell cancers, disrupted cell-cell adhesion that might lead to metastases can result from abnormalities in the expression of E-cadherin or its associated
360:
Cadherins behave as both receptors and ligands for other molecules. During development, their behavior assists at properly positioning cells: they are responsible for the separation of the different tissue layers and for cellular migration. In the very early stages of development,
179:-catenin), plakophilins (p120 catenin subfamily), and desmoplakins. The major function of desmoplakins is to bind to intermediate filament by interacting with plakoglobin, which attach to the ICS of desmogleins, desmocollins and plakophilins. Atypical cadherins, such as
374:
functions that maintain the cell structure, cell-cell adhesion, internal adhesions. They participate greatly in keeping the ability of the structured heart due to pumping and release blood. Because of the contribution of N-cadherins adhering strongly between the
419:
In epithelial cell cancers, disrupted cell to cell adhesion might lead to the development of secondary malignant growths; they are distant from the primary site of cancer and can result from the abnormalities in the expression of E-cadherins or its associated
406:
Additionally, the overexpression of type 5, 6, and 17 cadherins alone or in combination can lead to cancer metastasis, and ongoing research aims to block their ability to function as ligands for integral membrane proteins.
183:, retain the extracellular repeats and binding activities of the other cadherins, but may otherwise differ significantly in structure, and are typically involved in transmitting developmental signals rather than adhesion.
393:
After development, cadherins play a role in maintaining cell and tissue structure, and in cellular movement. Regulation of cadherin expression can occur through promoter methylation among other epigenetic mechanisms.
195:
One current model proposes that cells distinguish cadherin subtypes based on kinetic specificity rather than thermodynamic specificity, as different types of cadherin homotypic bonds have different lifetimes.
403:
adhesion, which can lead to local invasion and ultimately tumor development. Because E-cadherins play an important role in tumor suppression, they are also referred to as the "suppressors of invasion".
239:-dimers. Once the cell-cell adhesion between cadherins present in the cell membranes of two different cells has formed, adherens junctions can then be made when protein complexes, usually composed of
365:(epithelial cadherin) are most greatly expressed. Many cadherins are specified for specific functions in the cell, and they are differentially expressed in a developing embryo. For example, during
3054:
Daw S, Law S (February 2021). "The functional interplay of transcription factors and cell adhesion molecules in experimental myelodysplasia including hematopoietic stem progenitor compartment".
3017:
Chmelarova M, Baranova I, Ruszova E, Laco J, Hrochova K, Dvorakova E, et al. (October 2019). "Importance of
Cadherins Methylation in Ovarian Cancer: a Next Generation Sequencing Approach".
100:
2691:
Georgolios A, Batistatou A, Manolopoulos L, Charalabopoulos K (March 2006). "Role and expression patterns of E-cadherin in head and neck squamous cell carcinoma (HNSCC)".
2355:
Grigorian IY, Linkova NS, Polyakova VO, Paltseva EM, Kozlov KL (January 2016). "Signaling molecules of the endometrium: Gerontological and general pathological aspects".
605:
378:, the heart can overcome the fracture, deformation, and fatigue that can result from the blood pressure. N-cadherin takes part in the development of the heart during
345:
325:
261:
1688:
Volk T, Cohen O, Geiger B (September 1987). "Formation of heterotypic adherens-type junctions between L-CAM-containing liver cells and A-CAM-containing lens cells".
305:
281:
177:
224: dimer conformations: strand-swap dimers (S-dimers) and X-dimers. To date, over 100 types of cadherins in humans have been identified and sequenced.
212:
transmembrane component, and the remaining bulk of the protein is extra-cellular (outside the cell). The transmembrane component consists of single chain
669:. E-cadherins play a vital role in cancer formation, as deregulation of E-cadherin functions is a crucial step in the formation of breast cancer tumors.
139:
The cadherin family is essential in maintaining cell-cell contact and regulating cytoskeletal complexes. The cadherin superfamily includes cadherins,
3243:
2949:"In the first extracellular domain of E-cadherin, heterophilic interactions, but not the conserved His-Ala-Val motif, are required for adhesion"
216:
repeats. Because cadherins are Ca dependent, they have five tandem extracellular domain repeats that act as the binding site for Ca ions.
3794:
442:
levels of these molecules increase during the luteal phase while their expression is regulated by progesterone with endometrial calcitonin.
2786:
Reynolds AB, Carnahan RH (December 2004). "Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer".
227:
The functionality of cadherins relies upon the formation of two identical subunits, known as homodimers. The homodimeric cadherins create
1266:
104:
3196:
1028:
186:
Cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during
1088:
1083:
1068:
1063:
1058:
1053:
1048:
1043:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
883:
878:
868:
863:
517:
2602:
2585:
3392:
1251:
1247:
928:
918:
893:
853:
848:
2757:
Moran CJ, Joyce M, McAnena OJ (April 2005). "CDH1 associated gastric cancer: a report of a family and review of the literature".
2666:
2649:
1221:
1217:
1213:
1201:
1195:
1189:
769:
1135:
1098:
3236:
2485:
2450:
2090:
541:
383:
2320:
Cavallaro U, Schaffhauser B, Christofori G (February 2002). "Cadherins and the tumour progression: is it all in a switch?".
625:
1304:
3787:
3761:
126:
2555:
Beavon IR (August 2000). "The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation".
2147:
Beavon IR (August 2000). "The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation".
749:
Protocadherins are the largest mammalian subgroup of the cadherin superfamily of homophilic cell-adhesion proteins.
3264:
3229:
3201:
1225:
4021:
4016:
3471:
3291:
108:
2277:
Morales CP, Souza RF, Spechler SJ (November 2002). "Hallmarks of cancer progression in
Barrett's oesophagus".
613:
3281:
387:
64:
to function, hence their name. Cell-cell adhesion is mediated by extracellular cadherin domains, whereas the
1411:
Angst BD, Marcozzi C, Magee AI (February 2001). "The cadherin superfamily: diversity in form and function".
3780:
666:
379:
2392:"The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins"
65:
3709:
609:
3136:"The Involvement of Cell Adhesion Molecules, Tight Junctions, and Gap Junctions in Human Placentation"
554:
17:
2712:
Hazan RB, Qiao R, Keren R, Badano I, Suyama K (April 2004). "Cadherin switch in tumor progression".
3741:
1600:"Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants"
665:– E-cadherin (epithelial): E-cadherins are found in epithelial tissue; not to be confused with the
522:
464:
Ribbon representation of a repeating unit in the extracellular E-cadherin ectodomain of the mouse (
68:
associates with numerous adaptors and signaling proteins, collectively referred to as the cadherin
2106:
Reinhold WC, Reimers MA, Maunakea AK, Kim S, Lababidi S, Scherf U, et al. (February 2007).
95:
may contain an excessive amount of intricate detail that may interest only a particular audience
3821:
3256:
425:
45:
3134:
Adu-Gyamfi EA, Czika A, Gorleku PN, Ullah A, Panhwar Z, Ruan LL, et al. (February 2021).
2501:
Corso G, Figueiredo J, De
Angelis SP, Corso F, Girardi A, Pereira J, et al. (June 2020).
2440:
243:, bind to the cytoplasmic portion of the cadherin. Regulatory proteins include p-120 catenin,
3448:
3221:
2648:
Chun YS, Lindor NM, Smyrk TC, Petersen BT, Burgart LJ, Guilford PJ, et al. (July 2001).
330:
310:
246:
187:
53:
2235:"Beyond N-Cadherin, Relevance of Cadherins 5, 6 and 17 in Cancer Progression and Metastasis"
290:
266:
162:
3420:
3406:
3217:
2721:
1744:
1551:"Catenin-dependent cadherin function drives divisional segregation of spinal motor neurons"
592:
231:
with cadherins present in the membranes of other cells through changing conformation from
8:
3285:
2108:"Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells"
1376:
Hulpiau P, van Roy F (February 2009). "Molecular evolution of the cadherin superfamily".
561:
375:
32:
2912:
2725:
1981:
Gumbiner BM (August 2005). "Regulation of cadherin-mediated adhesion in morphogenesis".
1788:
Harris TJ, Tepass U (July 2010). "Adherens junctions: from molecules to morphogenesis".
1748:
4026:
3117:
3092:
3079:
3042:
2899:
2843:
2816:
2745:
2679:
2527:
2502:
2416:
2391:
2372:
2302:
2055:
2030:
2006:
1963:
1864:
1839:
1813:
1765:
1732:
1713:
1665:
1640:
1575:
1550:
1526:
1501:
1477:
1452:
1353:
1328:
1294:
1281:
2568:
2390:
Harrison OJ, Jin X, Hong S, Bahna F, Ahlsen G, Brasch J, et al. (February 2011).
2333:
2290:
2210:
2183:
2160:
1616:
1599:
3825:
3157:
3122:
3083:
3071:
3034:
3005:
2970:
2935:
2891:
2877:
2848:
2803:
2774:
2737:
2700:
2671:
2636:
2607:
2572:
2532:
2481:
2446:
2421:
2337:
2294:
2256:
2215:
2164:
2129:
2086:
2060:
1998:
1955:
1913:
1869:
1805:
1770:
1705:
1701:
1670:
1621:
1580:
1531:
1482:
1428:
1393:
1358:
600:
546:
466:
49:
3046:
2749:
2683:
2376:
2306:
2031:"Should I stay or should I go? Cadherin function and regulation in the neural crest"
2010:
1817:
1733:"Lifetime measurements reveal kinetic differences between homophilic cadherin bonds"
1717:
498:
3902:
3586:
3252:
3147:
3112:
3104:
3063:
3026:
2995:
2960:
2927:
2903:
2881:
2873:
2838:
2828:
2795:
2766:
2729:
2661:
2628:
2597:
2564:
2522:
2514:
2411:
2403:
2364:
2329:
2286:
2246:
2205:
2195:
2156:
2119:
2050:
2042:
1990:
1967:
1947:
1903:
1859:
1851:
1838:
Marie PJ, Haÿ E, Modrowski D, Revollo L, Mbalaviele G, Civitelli R (January 2014).
1797:
1760:
1752:
1697:
1660:
1652:
1611:
1570:
1566:
1562:
1521:
1513:
1472:
1464:
1420:
1385:
1348:
1340:
640:
588:
2650:"Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated?"
2476:
Lodish H, Berk A, Kaiser C, Krieger M, Bretscher A, Ploegh H, et al. (2013).
2124:
2107:
1641:"Cadherin-mediated cell sorting not determined by binding or adhesion specificity"
566:
3211:
2799:
1389:
650:
RNA splicing mechanisms. Invertebrates contain fewer than 20 types of cadherins.
510:
156:
3180:
3108:
2619:
Bryant DM, Stow JL (August 2004). "The ins and outs of E-cadherin trafficking".
1908:
1891:
1756:
1468:
3956:
3906:
3152:
3135:
3067:
2770:
2690:
3030:
2632:
2407:
2368:
1855:
1344:
4010:
3947:
3934:
3813:
3568:
2833:
2260:
2184:"Tumor suppressor gene E-cadherin and its role in normal and malignant cells"
744:
307:-catenin to the homodimer increases the stability of the classical cadherin.
228:
140:
2733:
107:
any relevant information, and removing excessive detail that may be against
3942:
3873:
3855:
3539:
3535:
3531:
3527:
3320:
3161:
3126:
3075:
3038:
3009:
2974:
2965:
2948:
2939:
2895:
2852:
2807:
2778:
2741:
2704:
2675:
2640:
2576:
2536:
2425:
2341:
2298:
2219:
2200:
2168:
2133:
2064:
2002:
1959:
1917:
1873:
1809:
1774:
1674:
1625:
1584:
1535:
1486:
1432:
1397:
1362:
709:
705:
701:
658:
Different members of the cadherin family are found in different locations.
459:
370:
213:
2611:
1709:
1656:
1424:
550:
3990:
3986:
3887:
3882:
3851:
3772:
3612:
3545:
3505:
3495:
3177:
2251:
2234:
1935:
1123:
719:
684:
662:
366:
362:
148:
2931:
2667:
10.1002/1097-0142(20010701)92:1<181::AID-CNCR1307>3.0.CO;2-J
1517:
203:
3981:
3951:
3892:
3842:
3804:
3718:
3689:
3684:
3679:
3602:
3523:
3093:"Single-molecule studies of classical and desmosomal cadherin adhesion"
3000:
2983:
2603:
10.1002/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D
2518:
1453:"Single-molecule studies of classical and desmosomal cadherin adhesion"
1165:
1093:
697:
534:
191:
144:
3187:
2886:
2046:
470:
3961:
3877:
3837:
3515:
3315:
1951:
52:
that let cells adhere to each other. Cadherins are a class of type-1
1994:
1938:(November 2000). "Cadherins in embryonic and neural morphogenesis".
1840:"Cadherin-mediated cell-cell adhesion and signaling in the skeleton"
1801:
3921:
3916:
3864:
3859:
3724:
3671:
3384:
3273:
3206:
1038:
1033:
505:
430:
284:
69:
3911:
3191:
2354:
1299:
1078:
1073:
968:
963:
958:
953:
948:
943:
938:
888:
873:
783:
779:
529:
421:
240:
57:
2913:"Polycystin: new aspects of structure, function, and regulation"
2862:"E-cadherin-catenin cell-cell adhesion complex and human cancer"
2861:
2319:
687:– P-cadherin (placental): P-cadherins are found in the placenta.
3977:
3581:
3452:
3342:
3305:
3295:
1276:
1243:
1238:
1234:
1230:
933:
923:
913:
908:
903:
898:
858:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
774:
620:
436:
180:
3251:
2500:
1329:"CDH2 and CDH11 act as regulators of stem cell fate decisions"
3756:
3733:
3729:
3657:
3647:
3642:
3637:
3632:
3627:
3576:
3456:
3438:
3434:
3424:
3410:
3396:
3372:
3367:
3362:
3357:
3352:
3347:
3330:
3325:
3299:
3016:
1271:
1260:
1256:
1207:
1183:
1177:
1171:
1159:
1153:
764:
759:
754:
678:
1378:
220:
Their extracellular domain interacts with two separate
3994:
3751:
3746:
3713:
3652:
3622:
3617:
3607:
3557:
3553:
3549:
3500:
3442:
3428:
3414:
3400:
3335:
3310:
3133:
1892:"Biophysical basis of cadherin mediated cell-cell adhesion"
1549:
Bello SM, Millo H, Rajebhosale M, Price SR (January 2012).
1147:
1141:
1129:
1117:
1103:
731:
727:
723:
713:
672:
637:
582:
493:
2859:
2105:
1548:
61:
2817:"CDH1 germline mutation in hereditary gastric carcinoma"
1837:
1731:
Bayas MV, Leung A, Evans E, Leckband D (February 2006).
3090:
2647:
2583:
2480:(Seventh ed.). New York: Worth Publ. p. 934.
2475:
2432:
1889:
1730:
1450:
675:– N-cadherin (neural): N-cadherins are found in neurons
2860:
Wijnhoven BP, Dinjens WN, Pignatelli M (August 2000).
2693:
1929:
1927:
2028:
1933:
1890:
Priest AV, Shafraz O, Sivasankar S (September 2017).
333:
313:
293:
269:
249:
165:
3091:
Priest AV, Koirala R, Sivasankar S (December 2019).
2711:
2389:
2276:
1451:
Priest AV, Koirala R, Sivasankar S (December 2019).
2438:
1924:
1597:
207:
Domain organization of different types of cadherins
2946:
2181:
1410:
1326:
339:
319:
299:
275:
255:
171:
2756:
2024:
2022:
2020:
1502:"Planar cell polarity in development and disease"
1499:
4008:
2785:
1598:Duguay D, Foty RA, Steinberg MS (January 2003).
1322:
1320:
2586:"Mutations of the human E-cadherin (CDH1) gene"
2584:Berx G, Becker KF, Höfler H, van Roy F (1998).
2272:
2270:
1687:
1638:
2313:
2232:
2017:
1885:
1883:
1375:
3788:
3237:
3140:Reproductive Sciences (Thousand Oaks, Calif.)
2920:Journal of the American Society of Nephrology
1833:
1831:
1829:
1827:
1446:
1444:
1442:
1317:
44:(named for "calcium-dependent adhesion") are
2814:
2788:Seminars in Cell & Developmental Biology
2383:
2267:
1787:
437:Correlation to endometrium and embryogenesis
3184:- view cadherin structure in interactive 3D
2239:International Journal of Molecular Sciences
2076:
2074:
2029:Taneyhill LA, Schiffmacher AT (June 2017).
1880:
1110:
3802:
3795:
3781:
3244:
3230:
2981:
2947:Renaud-Young M, Gallin WJ (October 2002).
2714:Annals of the New York Academy of Sciences
2618:
2507:Journal of Cellular and Molecular Medicine
2503:"E-cadherin deregulation in breast cancer"
1824:
1632:
1439:
458:
3151:
3116:
3097:Current Opinion in Biomedical Engineering
2999:
2964:
2885:
2842:
2832:
2815:Wang HD, Ren J, Zhang L (November 2004).
2665:
2601:
2526:
2415:
2250:
2209:
2199:
2123:
2054:
1907:
1863:
1764:
1724:
1664:
1615:
1591:
1574:
1525:
1493:
1476:
1457:Current Opinion in Biomedical Engineering
1369:
1352:
127:Learn how and when to remove this message
2071:
1980:
1639:Niessen CM, Gumbiner BM (January 2002).
1404:
410:
202:
31:
27:Calcium-dependent cell adhesion molecule
1681:
1500:Butler MT, Wallingford JB (June 2017).
1210:– cadherin 23 (neurosensory epithelium)
14:
4009:
3053:
2910:
2554:
2471:
2469:
2442:Encyclopedia of Molecular Pharmacology
2146:
1983:Nature Reviews. Molecular Cell Biology
1940:Nature Reviews. Molecular Cell Biology
1790:Nature Reviews. Molecular Cell Biology
1327:Alimperti S, Andreadis ST (May 2015).
3776:
3225:
2759:European Journal of Surgical Oncology
2233:Casal JI, Bartolomé RA (2019-07-09).
1934:Tepass U, Truong K, Godt D, Ikura M,
1506:Nature Reviews Molecular Cell Biology
151:, and more. In structure, they share
1305:List of target antigens in pemphigus
1126:– VE-cadherin (vascular endothelial)
681:– cadherin 12, type 2 (N-cadherin 2)
397:
79:
3056:Molecular and Cellular Biochemistry
2953:The Journal of Biological Chemistry
2466:
2080:
1156:– cadherin 10, type 2 (T2-cadherin)
24:
2547:
2439:Offermanns S, Rosenthal W (2008).
2083:The Molecular Biology of Cadherins
1150:– cadherin 9, type 2 (T1-cadherin)
25:
4038:
3170:
3019:Pathology & Oncology Research
2821:World Journal of Gastroenterology
1168:– T-cadherin – H-cadherin (heart)
738:
384:epithelial–mesenchymal transition
155:, which are the extracellular Ca-
2878:10.1046/j.1365-2168.2000.01513.x
190:. For example, cells containing
84:
2984:"Cadherin adhesome at a glance"
2494:
2348:
2226:
2175:
2140:
2099:
1974:
1781:
1186:– LI cadherin (liver-intestine)
287:. Binding of p-120 catenin and
2866:The British Journal of Surgery
2085:. Elsevier. pp. 264–274.
1844:Calcified Tissue International
1567:10.1523/jneurosci.4382-11.2012
1542:
388:induced pluripotent stem cells
355:
66:intracellular cytoplasmic tail
13:
1:
2982:Zaidel-Bar R (January 2013).
2569:10.1016/S0959-8049(00)00158-1
2334:10.1016/S0304-3835(01)00759-5
2291:10.1016/S0140-6736(02)11569-8
2161:10.1016/S0959-8049(00)00158-1
2125:10.1158/1535-7163.MCT-06-0609
2112:Molecular Cancer Therapeutics
1617:10.1016/S0012-1606(02)00016-7
1310:
691:
577:Available protein structures:
75:
2800:10.1016/j.semcdb.2004.09.003
1702:10.1016/0092-8674(87)90525-3
1390:10.1016/j.biocel.2008.09.027
667:APC/C activator protein CDH1
653:
643:for other Cadherin families.
198:
109:Knowledge's inclusion policy
7:
3109:10.1016/j.cobme.2019.08.006
2445:. Springer. pp. 306–.
2182:Nives Pećina-Šlaus (2003).
1909:10.1016/j.yexcr.2017.03.015
1757:10.1529/biophysj.105.069583
1645:The Journal of Cell Biology
1555:The Journal of Neuroscience
1469:10.1016/j.cobme.2019.08.006
1288:
350:
10:
4043:
3710:Lymphocyte homing receptor
3153:10.1007/s43032-020-00364-7
3068:10.1007/s11010-020-03920-6
2771:10.1016/j.ejso.2004.12.010
2557:European Journal of Cancer
2149:European Journal of Cancer
1896:Experimental Cell Research
1162:– OB-cadherin (osteoblast)
742:
3970:
3932:
3811:
3702:
3670:
3595:
3567:
3514:
3488:
3479:
3470:
3383:
3272:
3263:
3031:10.1007/s12253-018-0500-y
2633:10.1016/j.tcb.2004.07.007
2408:10.1016/j.str.2010.11.016
2369:10.1134/S2079057016010045
1856:10.1007/s00223-013-9733-7
1345:10.1016/j.scr.2015.02.002
635:
619:
599:
581:
576:
572:
560:
540:
528:
516:
504:
492:
484:
479:
457:
452:
3742:Carcinoembryonic antigen
3596:Unconventional/ungrouped
2911:Wilson PD (April 2001).
2834:10.3748/wjg.v10.i21.3088
1174:– M-cadherin (myotubule)
1111:Unconventional/ungrouped
453:Cadherin domain (repeat)
445:
3822:Cell adhesion molecules
3257:cell adhesion molecules
2988:Journal of Cell Science
2734:10.1196/annals.1294.016
2563:(13 Spec No): 1607–20.
2357:Advances in Gerontology
2155:(13 Spec No): 1607–20.
1413:Journal of Cell Science
347:-catenin and vinculin.
340:{\displaystyle \alpha }
320:{\displaystyle \alpha }
256:{\displaystyle \alpha }
46:cell adhesion molecules
37:and to actin filaments.
4022:Transmembrane proteins
4017:Cell adhesion proteins
2966:10.1074/jbc.M201256200
2621:Trends in Cell Biology
2478:Molecular Cell Biology
2201:10.1186/1475-2867-3-17
1120:– R-cadherin (retinal)
341:
321:
301:
300:{\displaystyle \beta }
277:
276:{\displaystyle \beta }
257:
241:α-, β-, and γ-catenins
208:
173:
172:{\displaystyle \beta }
54:transmembrane proteins
38:
3449:Glycoprotein IIb/IIIa
3202:The Cadherin Resource
1657:10.1083/jcb.200108040
1604:Developmental Biology
1425:10.1242/jcs.114.4.629
1204:– cadherin 20, type 2
1198:– cadherin 19, type 2
1192:– cadherin 18, type 2
1132:– K-cadherin (kidney)
411:Correlation to cancer
342:
322:
302:
278:
258:
206:
174:
56:, and they depend on
48:important in forming
35:
3421:Macrophage-1 antigen
3407:Integrin alphaXbeta2
2252:10.3390/ijms20133373
1144:– cadherin 8, type 2
1138:– cadherin 7, type 2
331:
311:
291:
267:
247:
163:
3286:Myelin protein zero
3265:Calcium-independent
3197:The cadherin family
2932:10.1681/ASN.V124834
2726:2004NYASA1014..155H
1749:2006BpJ....90.1385B
1737:Biophysical Journal
1518:10.1038/nrm.2017.11
3001:10.1242/jcs.111559
2519:10.1111/jcmm.15140
1333:Stem Cell Research
1295:Masatoshi Takeichi
337:
317:
297:
273:
253:
229:cell-cell adhesion
209:
169:
50:adherens junctions
39:
4004:
4003:
3903:membrane proteins
3826:Adherens junction
3770:
3769:
3698:
3697:
3666:
3665:
3472:Calcium-dependent
3466:
3465:
3253:Membrane proteins
2513:(11): 5930–5936.
2487:978-1-4292-3413-9
2452:978-3-540-38916-3
2092:978-0-12-394311-8
2047:10.1002/dvg.23028
647:
646:
631:
630:
626:structure summary
398:Tumour metastasis
137:
136:
129:
16:(Redirected from
4034:
3797:
3790:
3783:
3774:
3773:
3486:
3485:
3477:
3476:
3270:
3269:
3246:
3239:
3232:
3223:
3222:
3165:
3155:
3130:
3120:
3087:
3050:
3025:(4): 1457–1465.
3013:
3003:
2978:
2968:
2959:(42): 39609–16.
2943:
2917:
2907:
2889:
2856:
2846:
2836:
2811:
2782:
2753:
2708:
2687:
2669:
2644:
2615:
2605:
2580:
2541:
2540:
2530:
2498:
2492:
2491:
2473:
2464:
2463:
2461:
2459:
2436:
2430:
2429:
2419:
2387:
2381:
2380:
2352:
2346:
2345:
2317:
2311:
2310:
2285:(9345): 1587–9.
2274:
2265:
2264:
2254:
2230:
2224:
2223:
2213:
2203:
2179:
2173:
2172:
2144:
2138:
2137:
2127:
2103:
2097:
2096:
2078:
2069:
2068:
2058:
2026:
2015:
2014:
1978:
1972:
1971:
1952:10.1038/35040042
1931:
1922:
1921:
1911:
1887:
1878:
1877:
1867:
1835:
1822:
1821:
1785:
1779:
1778:
1768:
1728:
1722:
1721:
1685:
1679:
1678:
1668:
1636:
1630:
1629:
1619:
1595:
1589:
1588:
1578:
1546:
1540:
1539:
1529:
1497:
1491:
1490:
1480:
1448:
1437:
1436:
1419:(Pt 4): 629–41.
1408:
1402:
1401:
1373:
1367:
1366:
1356:
1324:
574:
573:
473:
462:
450:
449:
346:
344:
343:
338:
326:
324:
323:
318:
306:
304:
303:
298:
282:
280:
279:
274:
263:-catenin,
262:
260:
259:
254:
178:
176:
175:
170:
153:cadherin repeats
132:
125:
121:
118:
112:
88:
87:
80:
21:
4042:
4041:
4037:
4036:
4035:
4033:
4032:
4031:
4007:
4006:
4005:
4000:
3966:
3928:
3807:
3801:
3771:
3766:
3694:
3662:
3591:
3563:
3510:
3462:
3379:
3259:
3250:
3188:Cadherin domain
3173:
3168:
2994:(Pt 2): 373–8.
2915:
2872:(8): 992–1005.
2827:(21): 3088–93.
2550:
2548:Further reading
2545:
2544:
2499:
2495:
2488:
2474:
2467:
2457:
2455:
2453:
2437:
2433:
2388:
2384:
2353:
2349:
2318:
2314:
2275:
2268:
2231:
2227:
2188:Cancer Cell Int
2180:
2176:
2145:
2141:
2104:
2100:
2093:
2079:
2072:
2027:
2018:
1995:10.1038/nrm1699
1979:
1975:
1932:
1925:
1888:
1881:
1836:
1825:
1802:10.1038/nrm2927
1786:
1782:
1729:
1725:
1686:
1682:
1637:
1633:
1596:
1592:
1547:
1543:
1498:
1494:
1449:
1440:
1409:
1405:
1374:
1370:
1325:
1318:
1313:
1291:
1286:
1113:
1108:
747:
741:
694:
656:
475:
465:
448:
439:
413:
400:
358:
353:
332:
329:
328:
312:
309:
308:
292:
289:
288:
268:
265:
264:
248:
245:
244:
201:
164:
161:
160:
157:binding domains
133:
122:
116:
113:
99:Please help by
98:
89:
85:
78:
28:
23:
22:
15:
12:
11:
5:
4040:
4030:
4029:
4024:
4019:
4002:
4001:
3999:
3998:
3984:
3974:
3972:
3968:
3967:
3965:
3964:
3959:
3957:Focal adhesion
3954:
3945:
3939:
3937:
3930:
3929:
3927:
3926:
3925:
3924:
3919:
3914:
3907:Tight junction
3898:
3897:
3896:
3895:
3890:
3885:
3870:
3869:
3868:
3867:
3848:
3847:
3846:
3845:
3835:
3834:
3833:
3818:
3816:
3809:
3808:
3800:
3799:
3792:
3785:
3777:
3768:
3767:
3765:
3764:
3759:
3754:
3749:
3744:
3738:
3737:
3721:
3716:
3706:
3704:
3700:
3699:
3696:
3695:
3693:
3692:
3687:
3682:
3676:
3674:
3668:
3667:
3664:
3663:
3661:
3660:
3655:
3650:
3645:
3640:
3635:
3630:
3625:
3620:
3615:
3610:
3605:
3599:
3597:
3593:
3592:
3590:
3589:
3584:
3579:
3573:
3571:
3565:
3564:
3562:
3561:
3543:
3520:
3518:
3512:
3511:
3509:
3508:
3503:
3498:
3492:
3490:
3483:
3474:
3468:
3467:
3464:
3463:
3461:
3460:
3446:
3432:
3418:
3404:
3389:
3387:
3381:
3380:
3378:
3377:
3376:
3375:
3370:
3365:
3360:
3355:
3350:
3340:
3339:
3338:
3333:
3328:
3323:
3313:
3308:
3303:
3289:
3278:
3276:
3267:
3261:
3260:
3249:
3248:
3241:
3234:
3226:
3220:
3219:
3215:
3204:
3199:
3194:
3185:
3172:
3171:External links
3169:
3167:
3166:
3146:(2): 305–320.
3131:
3088:
3062:(2): 535–551.
3051:
3014:
2979:
2944:
2908:
2857:
2812:
2783:
2754:
2709:
2688:
2645:
2616:
2590:Human Mutation
2581:
2551:
2549:
2546:
2543:
2542:
2493:
2486:
2465:
2451:
2431:
2382:
2347:
2322:Cancer Letters
2312:
2266:
2225:
2174:
2139:
2118:(2): 391–403.
2098:
2091:
2081:Roy F (2013).
2070:
2016:
1973:
1923:
1879:
1823:
1780:
1743:(4): 1385–95.
1723:
1680:
1651:(2): 389–399.
1631:
1590:
1561:(2): 490–505.
1541:
1512:(6): 375–388.
1492:
1438:
1403:
1368:
1315:
1314:
1312:
1309:
1308:
1307:
1302:
1297:
1290:
1287:
1285:
1284:
1279:
1274:
1269:
1264:
1254:
1241:
1228:
1211:
1205:
1199:
1193:
1187:
1181:
1180:– KSP-cadherin
1175:
1169:
1163:
1157:
1151:
1145:
1139:
1133:
1127:
1121:
1114:
1112:
1109:
1107:
1106:
1101:
1096:
1091:
1086:
1081:
1076:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
777:
772:
767:
762:
757:
751:
743:Main article:
740:
739:Protocadherins
737:
736:
735:
717:
693:
690:
689:
688:
682:
676:
670:
655:
652:
645:
644:
633:
632:
629:
628:
623:
617:
616:
603:
597:
596:
586:
579:
578:
570:
569:
564:
558:
557:
544:
538:
537:
532:
526:
525:
520:
514:
513:
508:
502:
501:
496:
490:
489:
486:
482:
481:
477:
476:
463:
455:
454:
447:
444:
438:
435:
412:
409:
399:
396:
376:cardiomyocytes
357:
354:
352:
349:
336:
316:
296:
283:-catenin, and
272:
252:
200:
197:
168:
141:protocadherins
135:
134:
92:
90:
83:
77:
74:
26:
9:
6:
4:
3:
2:
4039:
4028:
4025:
4023:
4020:
4018:
4015:
4014:
4012:
3996:
3992:
3988:
3985:
3983:
3979:
3976:
3975:
3973:
3969:
3963:
3960:
3958:
3955:
3953:
3949:
3948:Hemidesmosome
3946:
3944:
3941:
3940:
3938:
3936:
3931:
3923:
3920:
3918:
3915:
3913:
3910:
3909:
3908:
3904:
3900:
3899:
3894:
3891:
3889:
3886:
3884:
3881:
3880:
3879:
3875:
3872:
3871:
3866:
3863:
3862:
3861:
3857:
3853:
3850:
3849:
3844:
3841:
3840:
3839:
3836:
3832:
3829:
3828:
3827:
3823:
3820:
3819:
3817:
3815:
3810:
3806:
3798:
3793:
3791:
3786:
3784:
3779:
3778:
3775:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3739:
3735:
3731:
3727:
3726:
3722:
3720:
3717:
3715:
3711:
3708:
3707:
3705:
3701:
3691:
3688:
3686:
3683:
3681:
3678:
3677:
3675:
3673:
3669:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3600:
3598:
3594:
3588:
3585:
3583:
3580:
3578:
3575:
3574:
3572:
3570:
3569:Protocadherin
3566:
3559:
3555:
3551:
3547:
3544:
3541:
3537:
3533:
3529:
3525:
3522:
3521:
3519:
3517:
3513:
3507:
3504:
3502:
3499:
3497:
3494:
3493:
3491:
3487:
3484:
3482:
3478:
3475:
3473:
3469:
3458:
3454:
3450:
3447:
3444:
3440:
3436:
3433:
3430:
3426:
3422:
3419:
3416:
3412:
3408:
3405:
3402:
3398:
3394:
3391:
3390:
3388:
3386:
3382:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3345:
3344:
3341:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3318:
3317:
3314:
3312:
3309:
3307:
3304:
3301:
3297:
3293:
3290:
3287:
3283:
3280:
3279:
3277:
3275:
3271:
3268:
3266:
3262:
3258:
3254:
3247:
3242:
3240:
3235:
3233:
3228:
3227:
3224:
3218:
3216:
3214:
3213:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3189:
3186:
3183:
3182:
3179:
3175:
3174:
3163:
3159:
3154:
3149:
3145:
3141:
3137:
3132:
3128:
3124:
3119:
3114:
3110:
3106:
3102:
3098:
3094:
3089:
3085:
3081:
3077:
3073:
3069:
3065:
3061:
3057:
3052:
3048:
3044:
3040:
3036:
3032:
3028:
3024:
3020:
3015:
3011:
3007:
3002:
2997:
2993:
2989:
2985:
2980:
2976:
2972:
2967:
2962:
2958:
2954:
2950:
2945:
2941:
2937:
2933:
2929:
2926:(4): 834–45.
2925:
2921:
2914:
2909:
2905:
2901:
2897:
2893:
2888:
2883:
2879:
2875:
2871:
2867:
2863:
2858:
2854:
2850:
2845:
2840:
2835:
2830:
2826:
2822:
2818:
2813:
2809:
2805:
2801:
2797:
2794:(6): 657–63.
2793:
2789:
2784:
2780:
2776:
2772:
2768:
2765:(3): 259–64.
2764:
2760:
2755:
2751:
2747:
2743:
2739:
2735:
2731:
2727:
2723:
2720:(1): 155–63.
2719:
2715:
2710:
2706:
2702:
2698:
2694:
2689:
2685:
2681:
2677:
2673:
2668:
2663:
2659:
2655:
2651:
2646:
2642:
2638:
2634:
2630:
2627:(8): 427–34.
2626:
2622:
2617:
2613:
2609:
2604:
2599:
2596:(4): 226–37.
2595:
2591:
2587:
2582:
2578:
2574:
2570:
2566:
2562:
2558:
2553:
2552:
2538:
2534:
2529:
2524:
2520:
2516:
2512:
2508:
2504:
2497:
2489:
2483:
2479:
2472:
2470:
2454:
2448:
2444:
2443:
2435:
2427:
2423:
2418:
2413:
2409:
2405:
2402:(2): 244–56.
2401:
2397:
2393:
2386:
2378:
2374:
2370:
2366:
2362:
2358:
2351:
2343:
2339:
2335:
2331:
2327:
2323:
2316:
2308:
2304:
2300:
2296:
2292:
2288:
2284:
2280:
2273:
2271:
2262:
2258:
2253:
2248:
2244:
2240:
2236:
2229:
2221:
2217:
2212:
2207:
2202:
2197:
2193:
2189:
2185:
2178:
2170:
2166:
2162:
2158:
2154:
2150:
2143:
2135:
2131:
2126:
2121:
2117:
2113:
2109:
2102:
2094:
2088:
2084:
2077:
2075:
2066:
2062:
2057:
2052:
2048:
2044:
2041:(6): e23028.
2040:
2036:
2032:
2025:
2023:
2021:
2012:
2008:
2004:
2000:
1996:
1992:
1989:(8): 622–34.
1988:
1984:
1977:
1969:
1965:
1961:
1957:
1953:
1949:
1946:(2): 91–100.
1945:
1941:
1937:
1930:
1928:
1919:
1915:
1910:
1905:
1901:
1897:
1893:
1886:
1884:
1875:
1871:
1866:
1861:
1857:
1853:
1849:
1845:
1841:
1834:
1832:
1830:
1828:
1819:
1815:
1811:
1807:
1803:
1799:
1796:(7): 502–14.
1795:
1791:
1784:
1776:
1772:
1767:
1762:
1758:
1754:
1750:
1746:
1742:
1738:
1734:
1727:
1719:
1715:
1711:
1707:
1703:
1699:
1696:(6): 987–94.
1695:
1691:
1684:
1676:
1672:
1667:
1662:
1658:
1654:
1650:
1646:
1642:
1635:
1627:
1623:
1618:
1613:
1610:(2): 309–23.
1609:
1605:
1601:
1594:
1586:
1582:
1577:
1572:
1568:
1564:
1560:
1556:
1552:
1545:
1537:
1533:
1528:
1523:
1519:
1515:
1511:
1507:
1503:
1496:
1488:
1484:
1479:
1474:
1470:
1466:
1462:
1458:
1454:
1447:
1445:
1443:
1434:
1430:
1426:
1422:
1418:
1414:
1407:
1399:
1395:
1391:
1387:
1384:(2): 349–69.
1383:
1379:
1372:
1364:
1360:
1355:
1350:
1346:
1342:
1339:(3): 270–82.
1338:
1334:
1330:
1323:
1321:
1316:
1306:
1303:
1301:
1298:
1296:
1293:
1292:
1283:
1280:
1278:
1275:
1273:
1270:
1268:
1265:
1262:
1258:
1255:
1253:
1249:
1245:
1242:
1240:
1236:
1232:
1229:
1227:
1223:
1219:
1215:
1212:
1209:
1206:
1203:
1200:
1197:
1194:
1191:
1188:
1185:
1182:
1179:
1176:
1173:
1170:
1167:
1164:
1161:
1158:
1155:
1152:
1149:
1146:
1143:
1140:
1137:
1134:
1131:
1128:
1125:
1122:
1119:
1116:
1115:
1105:
1102:
1100:
1097:
1095:
1092:
1090:
1087:
1085:
1082:
1080:
1077:
1075:
1072:
1070:
1067:
1065:
1062:
1060:
1057:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
990:
987:
985:
982:
980:
977:
975:
972:
970:
967:
965:
962:
960:
957:
955:
952:
950:
947:
945:
942:
940:
937:
935:
932:
930:
927:
925:
922:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
752:
750:
746:
745:Protocadherin
733:
729:
725:
721:
718:
715:
711:
707:
703:
699:
696:
695:
686:
683:
680:
677:
674:
671:
668:
664:
661:
660:
659:
651:
642:
639:
634:
627:
624:
622:
618:
615:
611:
607:
604:
602:
598:
594:
590:
587:
584:
580:
575:
571:
568:
565:
563:
559:
556:
552:
548:
545:
543:
539:
536:
533:
531:
527:
524:
521:
519:
515:
512:
509:
507:
503:
500:
497:
495:
491:
487:
483:
478:
472:
468:
461:
456:
451:
443:
434:
432:
427:
423:
417:
408:
404:
395:
391:
389:
385:
381:
380:embryogenesis
377:
372:
368:
364:
348:
334:
314:
294:
286:
270:
250:
242:
238:
234:
230:
225:
223:
219:
215:
205:
196:
193:
189:
184:
182:
166:
158:
154:
150:
146:
142:
131:
128:
120:
110:
106:
102:
96:
93:This section
91:
82:
81:
73:
71:
67:
63:
59:
55:
51:
47:
43:
34:
30:
19:
3943:Basal lamina
3874:Cytoskeleton
3856:Gap junction
3852:Ion channels
3830:
3803:Proteins of
3723:
3480:
3210:
3176:
3143:
3139:
3100:
3096:
3059:
3055:
3022:
3018:
2991:
2987:
2956:
2952:
2923:
2919:
2869:
2865:
2824:
2820:
2791:
2787:
2762:
2758:
2717:
2713:
2696:
2692:
2660:(1): 181–7.
2657:
2653:
2624:
2620:
2593:
2589:
2560:
2556:
2510:
2506:
2496:
2477:
2456:. Retrieved
2441:
2434:
2399:
2395:
2385:
2363:(1): 36–43.
2360:
2356:
2350:
2328:(2): 123–8.
2325:
2321:
2315:
2282:
2278:
2245:(13): 3373.
2242:
2238:
2228:
2191:
2187:
2177:
2152:
2148:
2142:
2115:
2111:
2101:
2082:
2038:
2034:
1986:
1982:
1976:
1943:
1939:
1902:(1): 10–13.
1899:
1895:
1850:(1): 46–54.
1847:
1843:
1793:
1789:
1783:
1740:
1736:
1726:
1693:
1689:
1683:
1648:
1644:
1634:
1607:
1603:
1593:
1558:
1554:
1544:
1509:
1505:
1495:
1460:
1456:
1416:
1412:
1406:
1381:
1377:
1371:
1336:
1332:
748:
657:
648:
440:
418:
414:
405:
401:
392:
371:neural plate
359:
236:
232:
226:
221:
217:
214:glycoprotein
210:
185:
152:
149:desmocollins
138:
123:
114:
101:spinning off
94:
41:
40:
29:
3991:Stereocilia
3935:cell–matrix
3888:Plakoglobin
3883:Desmoplakin
3546:Desmocollin
3178:Proteopedia
2699:(1): 5–14.
2458:14 December
720:Desmocollin
480:Identifiers
367:neurulation
363:E-cadherins
356:Development
235:-dimers to
188:development
145:desmogleins
4011:Categories
3987:Microvilli
3982:Kinocilium
3952:Tonofibril
3893:Tonofibril
3843:Desmoglein
3805:epithelium
3719:L-selectin
3690:P-selectin
3685:L-selectin
3680:E-selectin
3603:T-cadherin
3524:Desmoglein
3516:Desmosomal
2887:1765/56571
2194:(17): 17.
1311:References
698:Desmoglein
692:Desmosomal
589:structures
562:Membranome
192:N-cadherin
105:relocating
76:Background
4027:Cadherins
3962:Costamere
3878:Desmosome
3838:Desmosome
3814:cell–cell
3672:Selectins
3489:Classical
3481:Cadherins
3385:Integrins
3316:L1 family
3212:IPR002126
3103:: 43–50.
3084:222153001
2396:Structure
2261:1422-0067
1463:: 43–50.
1267:LOC389118
654:Classical
535:PDOC00205
511:IPR002126
474:)
390:(iPSCs).
369:, when a
335:α
315:α
295:β
271:β
251:α
199:Structure
167:β
117:July 2023
42:Cadherins
18:Cadherins
3922:MARVELD2
3917:Occludin
3865:Connexin
3860:Connexon
3831:Cadherin
3812:Lateral/
3725:integrin
3274:IgSF CAM
3207:InterPro
3181:Cadherin
3162:33146876
3127:31742239
3076:33011884
3047:53083365
3039:30368729
3010:23547085
2975:12154084
2940:11274246
2896:10931041
2853:15457549
2808:15561585
2779:15780560
2750:37486403
2742:15153430
2705:16761612
2684:11052015
2676:11443625
2641:15308209
2577:10959047
2537:32301282
2426:21300292
2377:87472683
2342:11804738
2307:22401564
2299:12443613
2220:14613514
2169:10959047
2134:17272646
2065:28253541
2011:25094246
2003:16025097
1960:11253370
1936:Peifer M
1918:28300566
1874:23657489
1818:13638902
1810:20571587
1775:16326909
1718:21428349
1675:11790800
1626:12645933
1585:22238085
1536:28293032
1487:31742239
1433:11171368
1398:18848899
1363:25771201
1289:See also
1039:PCDHGA12
1034:PCDHGA11
1029:PCDHGA10
606:RCSB PDB
506:InterPro
488:Cadherin
431:catenins
422:catenins
351:Function
285:vinculin
70:adhesome
3912:Claudin
3209::
3192:PROSITE
3118:6859941
2904:3083613
2844:4611247
2722:Bibcode
2612:9744472
2528:7294130
2417:3070544
2056:5468476
2035:Genesis
1968:1632053
1865:4272239
1766:1367289
1745:Bibcode
1710:3621349
1666:2199232
1576:3292792
1527:5826606
1478:6859941
1354:4439315
1300:Catenin
1089:PCDHGC5
1084:PCDHGC4
1079:PCDHGC3
1074:PCDHGB7
1069:PCDHGB6
1064:PCDHGB5
1059:PCDHGB4
1054:PCDHGB3
1049:PCDHGB2
1044:PCDHGB1
1024:PCDHGA9
1019:PCDHGA8
1014:PCDHGA7
1009:PCDHGA6
1004:PCDHGA5
999:PCDHGA4
994:PCDHGA3
989:PCDHGA2
984:PCDHGA1
979:PCDHB18
974:PCDHB17
969:PCDHB16
964:PCDHB15
959:PCDHB14
954:PCDHB13
949:PCDHB12
944:PCDHB11
939:PCDHB10
889:PCDHAC2
884:PCDHAC1
879:PCDHA13
874:PCDHA12
869:PCDHA11
864:PCDHA10
780:PCDH11X
530:PROSITE
499:PF00028
58:calcium
3971:Apical
3933:Basal/
3901:other
3587:PCDH19
3582:PCDH15
3453:ITGA2B
3343:Nectin
3321:L1-CAM
3311:PE-CAM
3306:VCAM-1
3160:
3125:
3115:
3082:
3074:
3045:
3037:
3008:
2973:
2938:
2902:
2894:
2851:
2841:
2806:
2777:
2748:
2740:
2703:
2682:
2674:
2654:Cancer
2639:
2610:
2575:
2535:
2525:
2484:
2449:
2424:
2414:
2375:
2340:
2305:
2297:
2279:Lancet
2259:
2218:
2211:270068
2208:
2167:
2132:
2089:
2063:
2053:
2009:
2001:
1966:
1958:
1916:
1872:
1862:
1816:
1808:
1773:
1763:
1716:
1708:
1673:
1663:
1624:
1583:
1573:
1534:
1524:
1485:
1475:
1431:
1396:
1361:
1351:
1277:RESDA1
1252:CLSTN3
1248:CLSTN2
1244:CLSTN1
1239:CELSR3
1235:CELSR2
1231:CELSR1
934:PCDHB9
929:PCDHB8
924:PCDHB7
919:PCDHB6
914:PCDHB5
909:PCDHB4
904:PCDHB3
899:PCDHB2
894:PCDHB1
859:PCDHA9
854:PCDHA8
849:PCDHA7
844:PCDHA6
839:PCDHA5
834:PCDHA4
829:PCDHA3
824:PCDHA2
819:PCDHA1
814:PCDH20
809:PCDH19
804:PCDH18
799:PCDH17
794:PCDH15
789:PCDH12
775:PCDH10
641:CL0159
621:PDBsum
595:
585:
555:SUPFAM
485:Symbol
218:
181:CELSR1
3978:Cilia
3762:EpCAM
3757:CD146
3734:LFA-1
3730:VLA-4
3703:Other
3658:CDH10
3648:CDH17
3643:CDH16
3638:CDH15
3633:CDH12
3628:CDH11
3577:PCDH1
3457:ITGB3
3439:CD49d
3435:VLA-4
3425:CD11b
3411:CD11c
3397:CD11a
3393:LFA-1
3373:CD155
3368:CADM3
3363:CADM1
3358:PVRL3
3353:PVRL2
3348:PVRL1
3331:NFASC
3326:NRCAM
3282:N-CAM
3080:S2CID
3043:S2CID
2916:(PDF)
2900:S2CID
2746:S2CID
2680:S2CID
2373:S2CID
2303:S2CID
2007:S2CID
1964:S2CID
1814:S2CID
1714:S2CID
1272:PCLKC
1261:DCHS2
1257:DCHS1
1226:CDH28
1222:CDH26
1218:CDH24
1214:CDH22
1208:CDH23
1202:CDH20
1196:CDH19
1190:CDH18
1184:CDH17
1178:CDH16
1172:CDH15
1166:CDH13
1160:CDH11
1154:CDH10
770:PCDH9
765:PCDH8
760:PCDH7
755:PCDH1
679:CDH12
551:SCOPe
542:SCOP2
518:SMART
446:Types
237:trans
222:trans
60:(Ca)
3995:STRC
3752:CD44
3747:CD24
3714:CD44
3653:CDH9
3623:CDH8
3618:CDH6
3613:CDH5
3608:CDH4
3558:DSC3
3554:DSC2
3550:DSC1
3540:DSG4
3536:DSG3
3532:DSG2
3528:DSG1
3506:CDH3
3501:CDH2
3496:CDH1
3443:CD29
3429:CD18
3415:CD18
3401:CD18
3336:CHL1
3292:ICAM
3158:PMID
3123:PMID
3072:PMID
3035:PMID
3006:PMID
2971:PMID
2936:PMID
2892:PMID
2849:PMID
2804:PMID
2775:PMID
2738:PMID
2718:1014
2701:PMID
2672:PMID
2637:PMID
2608:PMID
2573:PMID
2533:PMID
2482:ISBN
2460:2010
2447:ISBN
2422:PMID
2338:PMID
2295:PMID
2257:ISSN
2216:PMID
2165:PMID
2130:PMID
2087:ISBN
2061:PMID
1999:PMID
1956:PMID
1914:PMID
1870:PMID
1806:PMID
1771:PMID
1706:PMID
1690:Cell
1671:PMID
1622:PMID
1581:PMID
1532:PMID
1483:PMID
1429:PMID
1394:PMID
1359:PMID
1148:CDH9
1142:CDH8
1136:CDH7
1130:CDH6
1124:CDH5
1118:CDH4
1104:FAT4
1099:FAT2
732:DSC3
728:DSC2
724:DSC1
714:DSG4
710:DSG3
706:DSG2
702:DSG1
685:CDH3
673:CDH2
663:CDH1
638:Pfam
636:See
614:PDBj
610:PDBe
593:ECOD
583:Pfam
547:1nci
494:Pfam
471:3Q2V
426:CAMs
62:ions
3190:in
3148:doi
3113:PMC
3105:doi
3064:doi
3060:476
3027:doi
2996:doi
2992:126
2961:doi
2957:277
2928:doi
2882:hdl
2874:doi
2839:PMC
2829:doi
2796:doi
2767:doi
2730:doi
2662:doi
2629:doi
2598:doi
2565:doi
2523:PMC
2515:doi
2412:PMC
2404:doi
2365:doi
2330:doi
2326:176
2287:doi
2283:360
2247:doi
2206:PMC
2196:doi
2157:doi
2120:doi
2051:PMC
2043:doi
1991:doi
1948:doi
1904:doi
1900:358
1860:PMC
1852:doi
1798:doi
1761:PMC
1753:doi
1698:doi
1661:PMC
1653:doi
1649:156
1612:doi
1608:253
1571:PMC
1563:doi
1522:PMC
1514:doi
1473:PMC
1465:doi
1421:doi
1417:114
1386:doi
1349:PMC
1341:doi
1282:RET
1094:FAT
784:11Y
601:PDB
567:114
467:PDB
233:cis
103:or
4013::
3905::
3876::
3854::
3824::
3732:,
3712::
3556:,
3552:,
3538:,
3534:,
3530:,
3298:,
3255::
3156:.
3144:28
3142:.
3138:.
3121:.
3111:.
3101:12
3099:.
3095:.
3078:.
3070:.
3058:.
3041:.
3033:.
3023:25
3021:.
3004:.
2990:.
2986:.
2969:.
2955:.
2951:.
2934:.
2924:12
2922:.
2918:.
2898:.
2890:.
2880:.
2870:87
2868:.
2864:.
2847:.
2837:.
2825:10
2823:.
2819:.
2802:.
2792:15
2790:.
2773:.
2763:31
2761:.
2744:.
2736:.
2728:.
2716:.
2697:25
2695:.
2678:.
2670:.
2658:92
2656:.
2652:.
2635:.
2625:14
2623:.
2606:.
2594:12
2592:.
2588:.
2571:.
2561:36
2559:.
2531:.
2521:.
2511:24
2509:.
2505:.
2468:^
2420:.
2410:.
2400:19
2398:.
2394:.
2371:.
2359:.
2336:.
2324:.
2301:.
2293:.
2281:.
2269:^
2255:.
2243:20
2241:.
2237:.
2214:.
2204:.
2190:.
2186:.
2163:.
2153:36
2151:.
2128:.
2114:.
2110:.
2073:^
2059:.
2049:.
2039:55
2037:.
2033:.
2019:^
2005:.
1997:.
1985:.
1962:.
1954:.
1942:.
1926:^
1912:.
1898:.
1894:.
1882:^
1868:.
1858:.
1848:94
1846:.
1842:.
1826:^
1812:.
1804:.
1794:11
1792:.
1769:.
1759:.
1751:.
1741:90
1739:.
1735:.
1712:.
1704:.
1694:50
1692:.
1669:.
1659:.
1647:.
1643:.
1620:.
1606:.
1602:.
1579:.
1569:.
1559:32
1557:.
1553:.
1530:.
1520:.
1510:18
1508:.
1504:.
1481:.
1471:.
1461:12
1459:.
1455:.
1441:^
1427:.
1415:.
1392:.
1382:41
1380:.
1357:.
1347:.
1337:14
1335:.
1331:.
1319:^
1259:,
1250:,
1246:,
1237:,
1233:,
1224:,
1220:,
1216:,
730:,
726:,
712:,
708:,
704:,
612:;
608:;
591:/
553:/
549:/
523:CA
469::
433:.
424:.
147:,
143:,
72:.
3997:)
3993:(
3989:/
3980:/
3950:/
3858:/
3796:e
3789:t
3782:v
3736:)
3728:(
3560:)
3548:(
3542:)
3526:(
3459:)
3455:+
3451:(
3445:)
3441:+
3437:(
3431:)
3427:+
3423:(
3417:)
3413:+
3409:(
3403:)
3399:+
3395:(
3302:)
3300:5
3296:1
3294:(
3288:)
3284:(
3245:e
3238:t
3231:v
3164:.
3150::
3129:.
3107::
3086:.
3066::
3049:.
3029::
3012:.
2998::
2977:.
2963::
2942:.
2930::
2906:.
2884::
2876::
2855:.
2831::
2810:.
2798::
2781:.
2769::
2752:.
2732::
2724::
2707:.
2686:.
2664::
2643:.
2631::
2614:.
2600::
2579:.
2567::
2539:.
2517::
2490:.
2462:.
2428:.
2406::
2379:.
2367::
2361:6
2344:.
2332::
2309:.
2289::
2263:.
2249::
2222:.
2198::
2192:3
2171:.
2159::
2136:.
2122::
2116:6
2095:.
2067:.
2045::
2013:.
1993::
1987:6
1970:.
1950::
1944:1
1920:.
1906::
1876:.
1854::
1820:.
1800::
1777:.
1755::
1747::
1720:.
1700::
1677:.
1655::
1628:.
1614::
1587:.
1565::
1538:.
1516::
1489:.
1467::
1435:.
1423::
1400:.
1388::
1365:.
1343::
1263:,
782:/
734:)
722:(
716:)
700:(
130:)
124:(
119:)
115:(
111:.
97:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
