20:
134:, but in a differentiation-specific manner. The '2' and '3' isoforms of desmocollin and desmoglein are expressed in the lower epidermal layers, and the '1' proteins and desmoglein-4 are expressed in the upper epidermal layers. Different isoforms are located in the same individual cells, and single desmosomes contain more than one isoform of both desmocollin and desmoglein.
126:
The desmosomal cadherins are expressed in tissue-specific patterns. Desmocollin-2 and desmoglein-2 are found in all desmosome-containing tissues such as colon and cardiac muscle tissues, while other desmosomal cadherins are restricted to stratified epithelial tissues.
42:
to link adjacent cells by extracellular adhesion. There are seven desmosomal cadherins in humans, three desmocollins and four desmogleins. Desmosomal cadherins allow desmosomes to contribute to the integrity of tissue structure in multicellular living organisms.
137:
It is unclear why there are multiple desmosomal cadherin isoforms. It is thought that they may have different adhesive properties that are required at different levels in stratified epithelia or that they have specific functions in epithelial differentiation.
146:
Desmosomes are involved in cell-cell adhesion, and are particularly important for the integrity of heart and skin tissue. Because of this, desmocollin gene mutations can affect the adhesion of cells that undergo mechanical stress, notably
560:
Chatterjee, Diptendu; Fatah, Meena; Akdis, Deniz; Spears, Danna A; Koopmann, Tamara T; Mittal, Kirti; Rafiq, Muhammad A; Cattanach, Bruce M; Zhao, Qili; Healey, Jeff S; Ackerman, Michael J (2018-11-21).
237:
636:
257:
Harrison, Oliver J.; Brasch, Julia; Lasso, Gorka; Katsamba, Phinikoula S.; Ahlsen, Goran; Honig, Barry; Shapiro, Lawrence (2016-06-28).
785:
419:
Sun C, Wang L, Yang XX, Jiang YH, Guo XL (June 2019). "The aberrant expression or disruption of desmocollin2 in human diseases".
629:
232:
88:
encodes a pair of proteins: a longer 'a' form and a shorter 'b' form. The 'a' and 'b' forms differ in the length of their
1154:
657:
622:
864:
684:
563:"An autoantibody identifies arrhythmogenic right ventricular cardiomyopathy and participates in its pathogenesis"
19:
110:
anchor domain. Additionally, the 'a' form has an intracellular cadherin-like sequence domain, which provides
674:
168:
1102:
513:"Incorporation of desmocollin-2 into the plasma membrane requires N-glycosylation at multiple sites"
1134:
352:
182:
associated with arrhythmogenic right ventricular cardiomyopathy, and that anti-desmosomal cadherin
160:
649:
841:
614:
813:
799:
270:
93:
8:
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201:
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52:
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103:
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107:
100:
66:
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111:
1005:
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225:
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115:
1111:
1082:
1077:
1072:
995:
916:
511:
Brodehl A, Stanasiuk C, Anselmetti D, Gummert J, Milting H (May 2019).
204:
protein family, instrumental in the cytoplasmic anchoring of cadherins
195:
155:. Genetic disorders associated with desmocollin gene mutations include
89:
39:
326:"RCSB PDB - 5IRY: Crystal structure of human Desmocollin-1 ectodomain"
325:
259:"Structural basis of adhesive binding by desmocollins and desmogleins"
908:
708:
131:
35:
1117:
1064:
873:
777:
666:
183:
31:
510:
222:
protein family, associates intercellular bridges to cytoskeleton
974:
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735:
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688:
219:
644:
238:
List of conditions caused by problems with junctional proteins
1149:
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969:
849:
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723:
718:
692:
23:
Crystal structure of human
Desmocollin-1 ectodomain, PDB 5IRY
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1015:
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60:
559:
461:
178:
against desmosomal cadherins contributes to cardiac
373:
371:
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367:
365:
363:
361:
421:International Journal of Biological Macromolecules
384:Biochimica et Biophysica Acta (BBA) - Biomembranes
504:
1167:
462:Delva E, Tucker DK, Kowalczyk AP (August 2009).
418:
358:
130:All seven desmosomal cadherins are expressed in
380:"Desmosome structure, composition and function"
263:Proceedings of the National Academy of Sciences
169:arrhythmogenic right ventricular cardiomyopathy
55:of desmocollin proteins have been identified.
630:
377:
342:
637:
623:
468:Cold Spring Harbor Perspectives in Biology
594:
536:
487:
395:
351:at the U.S. National Library of Medicine
300:
282:
106:, an extracellular anchor domain, and an
92:tails. The protein pair is generated by
18:
186:may represent new therapeutic targets.
1168:
386:. Apical Junctional Complexes Part I.
114:for other desmosomal proteins such as
618:
198:, a subfamily of desmosomal cadherins
233:List of target antigens in pemphigus
34:, the transmembrane constituents of
99:Desmocollin has four cadherin-like
13:
378:Garrod D, Chidgey M (March 2008).
14:
1187:
323:
553:
455:
433:10.1016/j.ijbiomac.2019.03.041
412:
317:
250:
30:are a subfamily of desmosomal
1:
243:
121:
38:. They are co-expressed with
397:10.1016/j.bbamem.2007.07.014
174:There is also evidence that
141:
76:Desmocollin-3, coded by the
59:Desmocollin-1, coded by the
46:
7:
480:10.1101/cshperspect.a002543
189:
10:
1192:
1103:Lymphocyte homing receptor
1095:
1063:
988:
960:
907:
881:
872:
863:
776:
665:
656:
324:Bank, RCSB Protein Data.
1135:Carcinoembryonic antigen
989:Unconventional/ungrouped
579:10.1093/eurheartj/ehy567
353:Medical Subject Headings
161:palmoplantar keratoderma
650:cell adhesion molecules
529:10.1002/2211-5463.12631
284:10.1073/pnas.1606272113
567:European Heart Journal
24:
842:Glycoprotein IIb/IIIa
22:
16:Subfamily of proteins
814:Macrophage-1 antigen
800:Integrin alphaXbeta2
94:alternative splicing
679:Myelin protein zero
658:Calcium-independent
275:2016PNAS..113.7160H
25:
1163:
1162:
1091:
1090:
1059:
1058:
865:Calcium-dependent
859:
858:
646:Membrane proteins
573:(44): 3932–3944.
269:(26): 7160–7165.
157:Carvajal syndrome
84:Each desmocollin
1183:
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523:(5): 996–1007.
509:
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464:"The desmosome"
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69:, coded by the
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474:(2): a002543.
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149:cardiomyocytes
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962:Protocadherin
959:
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517:FEBS Open Bio
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390:(3): 572–87.
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170:
166:
165:Naxos disease
162:
158:
154:
153:keratinocytes
150:
139:
135:
133:
128:
119:
117:
113:
112:binding sites
109:
108:intracellular
105:
102:
101:extracellular
97:
95:
91:
87:
79:
75:
72:
68:
67:Desmocollin-2
65:
62:
58:
57:
56:
54:
44:
41:
37:
33:
29:
21:
1116:
938:
570:
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471:
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387:
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349:Desmocollins
344:
333:. Retrieved
330:www.rcsb.org
329:
319:
266:
262:
252:
180:inflammation
176:autoimmunity
173:
145:
136:
129:
125:
98:
83:
50:
28:Desmocollins
27:
26:
939:Desmocollin
427:: 378–386.
226:Desmoplakin
213:Plakophilin
208:Plakoglobin
116:plakoglobin
40:desmogleins
1112:L-selectin
1083:P-selectin
1078:L-selectin
1073:E-selectin
996:T-cadherin
917:Desmoglein
909:Desmosomal
335:2020-04-25
244:References
196:Desmoglein
184:antibodies
159:, striate
122:Expression
90:C-terminus
36:desmosomes
1065:Selectins
882:Classical
874:Cadherins
778:Integrins
709:L1 family
587:0195-668X
293:0027-8424
202:Armadillo
142:Disorders
132:epidermis
47:Structure
32:cadherins
1176:Proteins
1170:Category
1118:integrin
667:IgSF CAM
605:30239670
547:30942563
498:20066089
449:73495230
441:30851326
406:17854763
311:27298358
190:See also
53:isoforms
596:6247665
538:6487837
489:2742091
302:4932976
271:Bibcode
104:domains
980:PCDH19
975:PCDH15
846:ITGA2B
736:Nectin
714:L1-CAM
704:PE-CAM
699:VCAM-1
603:
593:
585:
545:
535:
496:
486:
447:
439:
404:
355:(MeSH)
309:
299:
291:
220:Plakin
167:, and
51:Three
1155:EpCAM
1150:CD146
1127:LFA-1
1123:VLA-4
1096:Other
1051:CDH10
1041:CDH17
1036:CDH16
1031:CDH15
1026:CDH12
1021:CDH11
970:PCDH1
850:ITGB3
832:CD49d
828:VLA-4
818:CD11b
804:CD11c
790:CD11a
786:LFA-1
766:CD155
761:CADM3
756:CADM1
751:PVRL3
746:PVRL2
741:PVRL1
724:NFASC
719:NRCAM
675:N-CAM
445:S2CID
1145:CD44
1140:CD24
1107:CD44
1046:CDH9
1016:CDH8
1011:CDH6
1006:CDH5
1001:CDH4
951:DSC3
947:DSC2
943:DSC1
933:DSG4
929:DSG3
925:DSG2
921:DSG1
899:CDH3
894:CDH2
889:CDH1
836:CD29
822:CD18
808:CD18
794:CD18
729:CHL1
685:ICAM
601:PMID
583:ISSN
543:PMID
494:PMID
437:PMID
402:PMID
388:1778
307:PMID
289:ISSN
151:and
86:gene
80:gene
78:DSC3
73:gene
71:DSC2
63:gene
61:DSC1
591:PMC
575:doi
533:PMC
525:doi
484:PMC
476:doi
429:doi
425:131
392:doi
297:PMC
279:doi
267:113
1172::
1125:,
1105::
949:,
945:,
931:,
927:,
923:,
691:,
648::
599:.
589:.
581:.
571:39
569:.
565:.
541:.
531:.
519:.
515:.
492:.
482:.
470:.
466:.
443:.
435:.
423:.
400:.
382:.
360:^
328:.
305:.
295:.
287:.
277:.
265:.
261:.
171:.
163:,
118:.
96:.
1129:)
1121:(
953:)
941:(
935:)
919:(
852:)
848:+
844:(
838:)
834:+
830:(
824:)
820:+
816:(
810:)
806:+
802:(
796:)
792:+
788:(
695:)
693:5
689:1
687:(
681:)
677:(
638:e
631:t
624:v
607:.
577::
549:.
527::
521:9
500:.
478::
472:1
451:.
431::
408:.
394::
338:.
313:.
281::
273::
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