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Burapitant

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Emonds-Alt X, Proietto V, Steinberg R, Oury-Donat F, VigĂ© X, Vilain P, et al. (December 2002). "SSR240600 acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]- 4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor: I. biochemical and
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Steinberg R, Alonso R, Rouquier L, Desvignes C, Michaud JC, Cudennec A, et al. (December 2002). "SSR240600 acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]-4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin 1 receptor: II. Neurochemical
273: 470:"Tachykinin regulation of cholinergic transmission in the limbic/prefrontal territory of the rat dorsal striatum: implication of new neurokinine 1-sensitive receptor binding site and interaction with enkephalin/mu opioid receptor transmission" 315:
InChI=1S/C31H35Cl2F6N3O3/c1-28(2,27(40)44)20-5-8-41(9-6-20)10-7-29(21-3-4-24(32)25(33)17-21)18-42(11-12-45-29)26(43)15-19-13-22(30(34,35)36)16-23(14-19)31(37,38)39/h3-4,13-14,16-17,20H,5-12,15,18H2,1-2H3,(H2,40,44)/t29-/m0/s1
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and was never developed for clinical use in humans, promising animal results from this and related compounds have led to a number of novel drugs from
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CC(C)(C1CCN(CC1)CC2(CN(CCO2)C(=O)CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C4=CC(=C(C=C4)Cl)Cl)C(=O)N
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2-acetyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl]piperidin-4-yl]-2-methylpropanamide
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which was one of the first compounds developed that acts as a potent and selective
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PĂ©rez S, Tierney A, Deniau JM, Kemel ML (December 2007).
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The Journal of Pharmacology and Experimental Therapeutics
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The Journal of Pharmacology and Experimental Therapeutics
467: 355:. While burapitant itself did not proceed beyond early 544: 957: 363:that have now been introduced into medical use. 115: 90: 940: 530: 947: 933: 537: 523: 186: 135: 155: 182: 958: 518: 895: 381:pharmacological characterization". 106: 13: 425:and behavioral characterization". 14: 997: 899: 489:10.1111/j.1471-4159.2007.04944.x 233: 227: 221: 215: 27: 320:Key:ZLNYUCXXSDDIFU-LJAQVGFWSA-N 966:Drugs not assigned an ATC code 461: 417: 373: 239: 209: 1: 366: 919:. You can help Knowledge by 7: 10: 1002: 894: 199:Chemical and physical data 986:Nervous system drug stubs 981:Chlorobenzene derivatives 976:Trifluoromethyl compounds 823: 774: 555: 477:Journal of Neurochemistry 337:) is a drug developed by 303: 283: 261: 248: 203: 198: 166: 146: 126: 101: 81: 61: 56: 40: 35: 26: 971:NK1 receptor antagonists 911:article relating to the 439:10.1124/jpet.102.040279 395:10.1124/jpet.102.040162 716:Nolpitantium besilate 546:Neurokinin receptor 23: 19: 928: 927: 892: 891: 328: 327: 274:Interactive image 168:CompTox Dashboard 16:Chemical compound 993: 949: 942: 935: 903: 896: 539: 532: 525: 516: 515: 509: 508: 474: 465: 459: 458: 421: 415: 414: 377: 276: 256: 241: 235: 229: 223: 217: 211: 191: 190: 176: 174: 159: 139: 119: 109: 108: 94: 31: 24: 22: 18: 1001: 1000: 996: 995: 994: 992: 991: 990: 956: 955: 954: 953: 893: 888: 828: 819: 779: 770: 560: 551: 543: 513: 512: 472: 466: 462: 422: 418: 378: 374: 369: 357:clinical trials 350: 324: 321: 316: 311: 310: 299: 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960:Categories 879:SB-222,200 874:SB-218,795 869:Pavinetant 815:Saredutant 810:Nepadutant 766:Vofopitant 726:Rolapitant 721:Orvepitant 706:Netupitant 701:Maropitant 691:Lanepitant 636:Figopitant 631:Ezlopitant 596:Casopitant 591:Burapitant 581:Aprepitant 549:modulators 367:References 361:this class 343:antagonist 331:Burapitant 262:3D model ( 250:Molar mass 157:E35SK332MS 128:ChemSpider 83:CAS Number 66:IUPAC name 21:Burapitant 884:Talnetant 864:Osanetant 836:Agonists: 805:Ibodutant 800:GR-159897 787:Agonists: 696:LY-306740 686:L-758,298 681:L-743,310 676:L-741,671 671:L-733,060 661:GW-597599 656:GR-203040 616:CP-122721 568:Agonists: 844:Senktide 731:RP-67580 621:Dapitant 611:CP-99994 606:CP-96345 497:17949415 447:12438542 403:12438541 353:receptor 345:for the 137:26519428 117:23649599 42:ATC code 711:NKP-608 666:HSP-117 601:CI-1021 505:8099165 411:1467606 205:Formula 103:PubChem 746:T-2328 641:FK-888 503:  495:  455:286897 453:  445:  409:  401:  288:SMILES 255:682.53 915:is a 907:This 501:S2CID 473:(PDF) 451:S2CID 407:S2CID 308:InChI 264:JSmol 917:stub 909:drug 493:PMID 443:PMID 399:PMID 148:UNII 49:none 485:doi 481:103 435:doi 431:303 391:doi 387:303 173:EPA 107:CID 962:: 825:NK 776:NK 557:NK 499:. 491:. 479:. 475:. 449:. 441:. 429:. 405:. 397:. 385:. 347:NK 222:Cl 219:35 213:31 948:e 941:t 934:v 923:. 827:3 778:2 559:1 538:e 531:t 524:v 507:. 487:: 457:. 437:: 413:. 393:: 349:1 333:( 266:) 243:3 240:O 237:3 234:N 231:6 228:F 225:2 216:H 210:C 175:) 171:(

Index


ATC code
IUPAC name
CAS Number
537034-22-3
PubChem
23649599
ChemSpider
26519428
UNII
E35SK332MS
CompTox Dashboard
DTXSID10968465
Edit this at Wikidata
Formula
Molar mass
JSmol
Interactive image
SMILES
InChI
Sanofi-Aventis
antagonist
NK1
receptor
clinical trials
this class
doi
10.1124/jpet.102.040162
PMID
12438541

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