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Breakthrough Prize in Life Sciences

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The award of $ 3 million, the largest award in the sciences, is given to researchers who have made discoveries that extend human life. The Prize is awarded annually, beginning in 2013, with six awards given in each subsequent year. Winners are expected to give public lectures and form the committee
1449:"for discovering the centrality of RNA in forming the active centers of the ribosome, the fundamental machinery of protein synthesis in all cells, thereby connecting modern biology to the origin of life and also explaining how many natural antibiotics disrupt protein synthesis." 2240:"for discovering TDP43 protein aggregates in frontotemporal dementia and amyotrophic lateral sclerosis, and revealing that different forms of alpha-synuclein, in different cell types, underlie Parkinson's disease and Multiple System Atrophy." 1001:"for the discovery of covalent modifications of histone proteins and their critical roles in the regulation of gene expression and chromatin organization, advancing the understanding of diseases ranging from birth defects to cancer." 1362:"for pioneering the sequencing of ancient DNA and ancient genomes, thereby illuminating the origins of modern humans, our relationships to extinct relatives such as Neanderthals, and the evolution of human populations and traits." 2335:"for deconstructing the complex behavior of parenting to the level of cell-types and their wiring, and demonstrating that the neural circuits governing both male and female-specific parenting behaviors are present in both sexes." 1795:"for elucidating the molecular pathogenesis of a type of inherited ALS, including the role of glia in neurodegeneration, and for establishing antisense oligonucleotide therapy in animal models of ALS and Huntington disease." 1580:"for discoveries of the genetic causes and biochemical mechanisms of spinocerebellar ataxia and Rett syndrome, findings that have provided insight into the pathogenesis of neurodegenerative and neurological diseases." 475:"for the discovery of general principles for identifying human disease genes, and enabling their application to medicine through the creation and analysis of genetic, physical and sequence maps of the human genome." 738:"for defining the interlocking circuits in the brain that malfunction in Parkinson's disease – this scientific foundation underlies the circuit-based treatment of Parkinson's disease by deep brain stimulation." 2847:"for discovering that narcolepsy is caused by the loss of a small population of brain cells that make a wake-promoting substance, paving the way for the development of new treatments for sleep disorders.." 1205:"for the development and implementation of optogenetics – the programming of neurons to express light-activated ion channels and pumps, so that their electrical activity can be controlled by light." 1321:"for the discovery of human genetic variants that alter the levels and distribution of cholesterol and other lipids, inspiring new approaches to the prevention of cardiovascular and liver disease." 1284:(APP) gene that cause early onset Alzheimer's disease, linking accumulation of APP-derived beta-amyloid peptide to Alzheimer's pathogenesis and inspiring new strategies for disease prevention." 2282:"for developing technology that allowed the design of proteins never seen before in nature, including novel proteins that have the potential for therapeutic intervention in human diseases." 1758:"for elucidating the sophisticated mechanism that mediates the perilous separation of duplicated chromosomes during cell division and thereby prevents genetic diseases such as cancer." 1117:"for harnessing an ancient mechanism of bacterial immunity into a powerful and general technology for editing genomes, with wide-ranging implications across biology and medicine." 3105:"For identifying GBA1 and LRRK2 as risk genes for Parkinson's disease, implicating autophagy and lysosomal biology as critical contributors to the pathogenesis of the disease." 1683:"for elucidating the unfolded protein response, a cellular quality-control system that detects disease-causing unfolded proteins and directs cells to take corrective measures." 2944: 1973:"for discovering hidden structures in cells by developing super-resolution imaging – a method that transcends the fundamental spatial resolution limit of light microscopy." 964:"for the discovery and pioneering work on the development of high-frequency deep brain stimulation (DBS), which has revolutionized the treatment of Parkinson's disease." 2742: 840: 2589:"for the development of a robust and affordable method to determine DNA sequences on a massive scale, which has transformed the practice of science and medicine." 2453:"for elucidating the molecular basis of neurodegenerative and cardiac transthyretin diseases, and for developing tafamidis, a drug that slows their progression." 3084: 3059: 3032: 2985: 2822: 2788: 2717: 2672: 2601: 2428: 2388: 2351: 2088: 1989: 1936: 1461: 1424: 1379: 1296: 1255: 1054: 881: 713: 532: 401: 262: 3588: 2776:"for developing a deep learning AI method that rapidly and accurately predicts the three-dimensional structure of proteins from their amino acid sequence.." 3330: 4355: 3300: 4274: 2697:"for discovering a fundamental mechanism of cellular organization mediated by phase separation of proteins and RNA into membraneless liquid droplets." 1365: 3861: 2026:"for elucidating how DNA triggers immune and autoimmune responses from the interior of a cell through the discovery of the DNA-sensing enzyme cGAS." 1404:"for elucidating how eukaryotic cells sense and respond to damage in their DNA and providing insights into the development and treatment of cancer." 2941:"For the development of chimeric antigen receptor T cell immunotherapy whereby the patient's T cells are modified to target and kill cancer cells." 4359: 2896: 2376:"for discovering that fetal DNA is present in maternal blood and can be used for the prenatal testing of trisomy 21 and other genetic disorders" 1837:"for the development of an effective antisense oligonucleotide therapy for children with the neurodegenerative disease spinal muscular atrophy." 1324: 4419: 1486:"for pioneering research on the Wnt pathway, one of the crucial intercellular signaling systems in development, cancer and stem cell biology." 3113: 3020:"For developing life-transforming drug combinations that repair the defective chloride channel protein in patients with cystic fibrosis." 3581: 1045: 175: 3973: 3699: 1630:"for discovering how plants optimize their growth, development, and cellular structure to transform sunlight into chemical energy." 3145: 3242: 2194: 1686: 1162: 613: 129: 2976: 2850: 2411:"for elucidating a quality control pathway that clears damaged mitochondria and thereby protects against Parkinson's Disease." 523: 3466:"Breakthrough Prize – Winners Of The 2022 Breakthrough Prizes In Life Sciences, Fundamental Physics And Mathematics Announced" 3441:"Breakthrough Prize – Winners Of The 2021 Breakthrough Prizes In Life Sciences, Fundamental Physics And Mathematics Announced" 3574: 3416:"Breakthrough Prize – Winners Of The 2020 Breakthrough Prize In Life Sciences, Fundamental Physics And Mathematics Announced" 1927: 1633: 1208: 1128: 831: 560: 478: 3853: 3528: 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to decide future winners. The ceremony takes place in the San Francisco Bay Area, with the symposiums alternating between
4409: 2379: 1798: 441: 1120: 872: 125: 2072:"for the discovery of a new endocrine system through which adipose tissue signals the brain to regulate food intake." 3606: 3201: 2150:"for discovering functions of molecular chaperones in mediating protein folding and preventing protein aggregation." 2113:"for discovering functions of molecular chaperones in mediating protein folding and preventing protein aggregation." 2704: 2342: 2289: 2157: 2079: 2033: 1980: 1690: 1637: 1591: 1493: 1415: 1407: 1328: 1246: 1124: 650: 519: 101: 3338: 4013: 3630: 2029: 1531:, the recycling system that cells use to generate nutrients from their own inessential or damaged components." 1079: 790: 599: 3308: 4404: 3187: 3149: 2414: 1874: 1534: 609: 298: 3881: 3817: 3785: 2708: 1587: 704: 2502:"for engineering modified RNA technology which enabled rapid development of effective COVID-19 vaccines." 4086: 3805: 3183: 2858: 2793: 2543: 2509: 2456: 2243: 1583: 438:"for discoveries in the mechanisms of angiogenesis that led to therapies for cancer and eye diseases." 3791: 3206: 2915: 1287: 1281: 1042:, a class of tiny RNA molecules that inhibit translation or destabilize complementary mRNA targets." 967: 288: 3502:"BREAKTHROUGH PRIZE ANNOUNCES 2024 LAUREATES IN LIFE SCIENCES, FUNDAMENTAL PHYSICS, AND MATHEMATICS" 3109: 4399: 4389: 4262: 2285: 2262: 654: 3729: 4414: 4394: 4299: 4160: 4035: 3967: 3865: 3216: 2626: 2592: 2557: 2153: 1698: 1645: 1260: 389:, illuminating how they protect chromosome ends and their role in genome instability in cancer." 3267: 4313: 4146: 3211: 3023: 2677: 2075: 1411: 1142: 1083: 1004: 392: 294: 204: 2124: 2900: 1840: 333: 4424: 4256: 4120: 3939: 3889: 2700: 2208: 1761: 1216: 918:"for discovering critical molecular determinants and biological functions of intracellular 886: 621: 253: 1179: 667: 8: 4279: 4240: 4130: 2052: 1489: 1242: 919: 564: 133: 449: 4333: 4244: 4126: 3963: 3913: 3877: 3795: 3763: 3682: 3597: 3533: 2864: 2356: 2338: 2093: 1994: 1976: 1384: 944: 824:"for discoveries leading to the development of controlled drug-release systems and new 537: 496: 339: 91: 2517: 1166: 787:"for the discovery of Target of Rapamycin (TOR) and its role in cell growth control." 201:"for the genetics of neural circuits and behavior, and synaptic guidepost molecules." 4248: 4222: 4168: 4116: 4074: 4054: 3903: 3899: 3709: 3658: 3648: 3275: 2130: 1854: 1342: 845: 406: 181: 4291: 2470: 4367: 4317: 4287: 4218: 4212: 4186: 4112: 4100: 4062: 4003: 3983: 3893: 3775: 3759: 3721: 3676: 3618: 3163: 2722: 2433: 1817: 1775: 1724: 1507: 1185: 741: 673: 605: 267: 2464: 1336: 4363: 4343: 4329: 4303: 4266: 4178: 4174: 4156: 4142: 4108: 4094: 4090: 4082: 4017: 3997: 3979: 3945: 3801: 3767: 3751: 3614: 3561: 3127: 2958: 2827: 2606: 2303: 2046: 1429: 1222: 1097: 755: 627: 578: 482: 97: 3361:"Breakthrough Prize – Breakthrough Prize Awarded $ 22 Million In Science Prizes" 1091: 4351: 4325: 4321: 4230: 4204: 4070: 4058: 3959: 3949: 3921: 3885: 3873: 3869: 3733: 3652: 3566: 3178: 3037: 2952: 2771: 2756: 2750: 2737: 2621: 2584: 2256: 2165: 1941: 1753: 1704: 1275: 981: 455: 353: 218: 2191:"for discovering molecules, cells, and mechanisms underlying pain sensation." 1604: 250:"for linkage mapping of Mendelian disease in humans using DNA polymorphisms." 4383: 4347: 4295: 4226: 4152: 4134: 4104: 4025: 4021: 3987: 3929: 3857: 3827: 3809: 3771: 3741: 3717: 3688: 3670: 3642: 3279: 3140: 3075: 3050: 3015: 2990: 2936: 2891: 2842: 2808: 2692: 2538: 2523: 2497: 2448: 2406: 2330: 2277: 2235: 2186: 2145: 2067: 2021: 1968: 1915: 1888: 1869: 1832: 1790: 1678: 1625: 1575: 1466: 1444: 1399: 1316: 1237: 1200: 1112: 1074: 1033: 1018: 996: 913: 860: 819: 804: 782: 733: 718: 688: 642: 552: 511: 470: 433: 380: 282: 245: 196: 113: 78: 3390: 2634: 1924:, an abnormal chromosome number resulting from chromosome mis-segregation." 4307: 4252: 4234: 4200: 4196: 4066: 3917: 3835: 3725: 2921: 2640: 2171: 1651: 1610: 866: 825: 312: 4208: 4190: 4164: 4138: 4078: 3907: 3849: 3845: 3755: 3626: 3622: 1738: 1548: 1501: 1481: 1301: 1136: 1059: 770: 368: 327: 233: 109: 105: 3501: 3489: 3465: 3440: 3415: 3360: 4182: 4031: 3925: 3831: 3813: 3737: 3664: 1921: 698: 35:
Research aimed at curing intractable diseases and extending human life.
347: 306: 4339: 4270: 3779: 3713: 2371: 2202: 1528: 1039: 839: 386: 938: 572: 3636: 3391:"Breakthrough Prize – Life Sciences Breakthrough Prize – Laureates" 3157: 2813: 2779: 2505: 1811: 3121: 2297: 865:"for the discovery of genes and biochemical mechanisms that cause 490: 3100: 2485: 2108: 1903: 1848: 1666: 1563: 975: 925: 749: 117: 1769: 798: 212: 4007: 2971: 2655: 2318: 1882: 1357: 1157: 959: 901: 694: 3243:"Breakthrough Prize announced by Silicon Valley entrepreneurs" 1542: 3003: 2879: 2572: 2223: 2009: 1956: 1732: 1719: 1522: 593: 421: 3839: 2743:
Max Planck Institute of Molecular Cell Biology and Genetics
1038:"for the discovery of a new world of genetic regulation by 1012: 3083: 3058: 3031: 2984: 2821: 2787: 2716: 2671: 2600: 2427: 2387: 2350: 2087: 1988: 1935: 1460: 1423: 1378: 1295: 1254: 1053: 880: 712: 531: 400: 261: 96:
is a scientific award, funded by internet entrepreneurs
3520: 2945:
Perelman School of Medicine, University of Pennsylvania
3529:"$ 3 Million Prizes Will Go to Mathematicians, Too" 1366:Max Planck Institute for Evolutionary Anthropology 647:"for cancer genomics and tumor suppressor genes." 4381: 3596: 2897:University of Texas Southwestern Medical Center 2556: 1325:University of Texas Southwestern Medical Center 108:of Google; entrepreneur and venture capitalist 3108:Hertie Institute for Clinical Brain Research, 557:"for characterization of human cancer genes." 116:, one of the founders of the genetics company 3582: 3240: 3114:German Center for Neurodegenerative Diseases 16:Award for breakthroughs in the life sciences 1141: 3589: 3575: 2863: 2676: 1221: 1046:University of Massachusetts Medical School 885: 626: 3974:The Event Horizon Telescope Collaboration 3207:Breakthrough Prize in Fundamental Physics 2605: 1774: 516:"for cancer genes and targeted therapy." 3146:National Human Genome Research Institute 2755: 2522: 2051: 577: 536: 352: 217: 180: 3526: 2195:University of California, San Francisco 2129: 1853: 1816: 1737: 1687:University of California, San Francisco 1383: 1163:Helmholtz Centre for Infection Research 943: 672: 614:University of California, San Francisco 495: 405: 266: 130:University of California, San Francisco 4382: 3385: 3383: 3381: 2977:Memorial Sloan Kettering Cancer Center 2851:Stanford University School of Medicine 2826: 2792: 2469: 2170: 1940: 1650: 1547: 1506: 1428: 1184: 1096: 1058: 1017: 844: 803: 717: 524:Memorial Sloan-Kettering Cancer Center 454: 4420:Russian science and technology awards 3570: 3527:Overbye, Dennis (December 13, 2013). 2721: 2639: 2432: 2392: 2302: 2261: 2092: 1928:Massachusetts Institute of Technology 1920:"for determining the consequences of 1634:Salk Institute for Biological Studies 1609: 1465: 1341: 1300: 1259: 1209:Massachusetts Institute of Technology 1129:Lawrence Berkeley National Laboratory 980: 832:Massachusetts Institute of Technology 561:Massachusetts Institute of Technology 479:Massachusetts Institute of Technology 2117:Max Planck Institute of Biochemistry 1993: 1887: 1703: 1453:University of California, Santa Cruz 754: 291:and its role in cancer metabolism." 3378: 3236: 3234: 3232: 2380:The Chinese University of Hong Kong 2207: 1799:University of California, San Diego 442:University of California, San Diego 27:Breakthrough Prize in Life Sciences 13: 3241:Rory Carroll (February 20, 2013). 2355: 1280:"for discovering mutations in the 1121:University of California, Berkeley 873:Yale University School of Medicine 336:in tissue stem cells and cancer." 126:University of California, Berkeley 14: 4436: 3555: 3202:Breakthrough Prize in Mathematics 3229: 3171: 3156: 3133: 3120: 3093: 3082: 3068: 3057: 3043: 3030: 3008: 2996: 2983: 2964: 2951: 2929: 2914: 2884: 2872: 2857: 2835: 2820: 2801: 2786: 2764: 2749: 2730: 2715: 2685: 2670: 2648: 2633: 2614: 2599: 2577: 2565: 2550: 2531: 2516: 2490: 2478: 2463: 2441: 2426: 2399: 2386: 2364: 2349: 2323: 2311: 2296: 2270: 2255: 2228: 2216: 2201: 2179: 2164: 2138: 2123: 2101: 2086: 2060: 2045: 2014: 2002: 1987: 1961: 1949: 1934: 1908: 1896: 1881: 1862: 1847: 1825: 1810: 1783: 1768: 1746: 1731: 1712: 1697: 1671: 1659: 1644: 1618: 1603: 1568: 1556: 1541: 1515: 1500: 1474: 1459: 1437: 1422: 1392: 1377: 1350: 1335: 1309: 1294: 1268: 1253: 1230: 1215: 1193: 1178: 1150: 1135: 1105: 1090: 1067: 1052: 1026: 1011: 989: 974: 952: 937: 906: 894: 879: 853: 838: 812: 797: 775: 763: 748: 726: 711: 681: 666: 635: 620: 586: 571: 545: 530: 504: 489: 463: 448: 426: 414: 399: 373: 361: 346: 320: 305: 275: 260: 238: 226: 211: 189: 174: 3494: 3483: 2705:Howard Hughes Medical Institute 2343:Howard Hughes Medical Institute 2290:Howard Hughes Medical Institute 2158:Howard Hughes Medical Institute 2080:Howard Hughes Medical Institute 2034:Howard Hughes Medical Institute 1981:Howard Hughes Medical Institute 1691:Howard Hughes Medical Institute 1638:Howard Hughes Medical Institute 1592:Howard Hughes Medical Institute 1494:Howard Hughes Medical Institute 1416:Howard Hughes Medical Institute 1329:Howard Hughes Medical Institute 1247:Howard Hughes Medical Institute 1125:Howard Hughes Medical Institute 651:Howard Hughes Medical Institute 520:Howard Hughes Medical Institute 79:breakthroughprizeinlifesciences 3458: 3433: 3408: 3353: 3323: 3293: 3260: 2030:UT Southwestern Medical Center 1080:Massachusetts General Hospital 791:Biozentrum University of Basel 701:as effective cancer therapy." 600:induced pluripotent stem cells 1: 3222: 2415:National Institutes of Health 1875:Cold Spring Harbor Laboratory 1535:Tokyo Institute of Technology 610:J. David Gladstone Institutes 299:Weill Cornell Medical College 3882:Sudbury Neutrino Observatory 2709:Marine Biological Laboratory 1408:Brigham and Women's Hospital 705:M. D. Anderson Cancer Center 332:"for describing the role of 139: 7: 3806:Supernova Cosmology Project 3195: 3184:National Institute on Aging 10: 4443: 4410:Awards established in 2013 2544:University of Pennsylvania 2510:University of Pennsylvania 2457:Scripps Research Institute 2244:University of Pennsylvania 1584:Baylor College of Medicine 168: 4045: 3698: 3605: 3331:"Breakthrough Prize 2015" 3301:"Breakthrough Prize 2014" 3104: 3022: 3019: 2940: 2906: 2846: 2775: 2696: 2664: 2588: 2501: 2420: 2249: 2039: 1836: 1804: 1682: 1597: 1588:Texas Children's Hospital 1371: 1288:University College London 1282:amyloid precursor protein 1204: 1172: 1116: 1037: 968:Joseph Fourier University 931: 660: 163: 157: 152: 73: 65: 57: 39: 31: 26: 2286:University of Washington 655:Johns Hopkins University 4300:Shankar Balasubramanian 4036:Alexander Zamolodchikov 3968:Peter van Nieuwenhuizen 3547:(subscription required) 3217:List of medicine awards 2627:University of Cambridge 2593:University of Cambridge 2558:Shankar Balasubramanian 2154:Yale School of Medicine 4314:Clifford P. Brangwynne 4147:Emmanuelle Charpentier 3212:List of biology awards 3110:University of Tübingen 3024:Vertex Pharmaceuticals 2678:Clifford P. Brangwynne 2076:Rockefeller University 1412:Harvard Medical School 1143:Emmanuelle Charpentier 1084:Harvard Medical School 1005:Rockefeller University 693:"for the discovery of 393:Rockefeller University 295:Harvard Medical School 287:"for the discovery of 205:Rockefeller University 45:; 11 years ago 43:February 20, 2013 3818:High-Z Supernova Team 3470:breakthroughprize.org 3445:breakthroughprize.org 3420:breakthroughprize.org 3395:breakthroughprize.org 3365:breakthroughprize.org 3341:on September 13, 2016 3335:breakthroughprize.org 3305:breakthroughprize.org 2901:University of Tsukuba 1841:Ionis Pharmaceuticals 4405:International awards 4257:Virginia Man-Yee Lee 4121:Alexander Varshavsky 3940:Jocelyn Bell Burnell 3838:and contributors to 3508:. September 14, 2023 2701:Princeton University 2209:Virginia Man-Yee Lee 1762:University of Oxford 887:Alexander Varshavsky 254:Princeton University 4241:Jeffrey M. Friedman 4131:Charles David Allis 3816:and members of the 3804:and members of the 3268:"Take that, Alfred" 2053:Jeffrey M. Friedman 1490:Stanford University 1243:Stanford University 920:protein degradation 565:Whitehead Institute 134:Stanford University 4334:Masashi Yanagisawa 4245:Franz-Ulrich Hartl 4175:Stephen J. Elledge 4127:Alim Louis Benabid 4014:Charles H. Bennett 3964:Daniel Z. Freedman 3914:Charles L. Bennett 3878:Arthur B. McDonald 3866:Kōichirō Nishikawa 3796:John Henry Schwarz 3786:Alexander Polyakov 3764:Michel Della Negra 3683:Daniel A. Spielman 3598:Breakthrough Prize 3534:The New York Times 3506:BREAKTHROUGH PRIZE 3311:on October 1, 2017 3064:Fredrick Van Goor 2865:Masashi Yanagisawa 2357:Yuk Ming Dennis Lo 2339:Harvard University 2094:Franz-Ulrich Hartl 1995:Zhijian James Chen 1977:Harvard University 1385:Stephen J. Elledge 945:Alim-Louis Benabid 538:Robert A. Weinberg 497:Charles L. Sawyers 340:Hubrecht Institute 92:Breakthrough Prize 4377: 4376: 4356:Fredrick Van Goor 4249:Arthur L. Horwich 4223:Adrian R. Krainer 4117:Richard P. Lifton 4075:Napoleone Ferrara 4055:Cornelia Bargmann 3904:Andrew Strominger 3900:Joseph Polchinski 3710:Nima Arkani-Hamed 3659:Vincent Lafforgue 3649:Christopher Hacon 3193: 3192: 2131:Arthur L. Horwich 1855:Adrian R. Krainer 1527:"for elucidating 846:Richard P. Lifton 407:Napoleone Ferrara 385:"for research on 182:Cornelia Bargmann 87: 86: 4432: 4368:Andrew Singleton 4318:Anthony A. Hyman 4288:Jeffery W. Kelly 4283: 4275:Richard J. Youle 4219:C. Frank Bennett 4213:Don W. Cleveland 4187:Yoshinori Ohsumi 4113:Robert S. Langer 4101:James P. Allison 4063:Lewis C. Cantley 4004:Hidetoshi Katori 3984:Jens H. Gundlach 3894:Super-Kamiokande 3776:Joseph Incandela 3760:Fabiola Gianotti 3722:Maxim Kontsevich 3677:Takuro Mochizuki 3619:Maxim Kontsevich 3591: 3584: 3577: 3568: 3567: 3549: 3548: 3545: 3543: 3541: 3524: 3518: 3517: 3515: 3513: 3498: 3492: 3487: 3481: 3480: 3478: 3476: 3462: 3456: 3455: 3453: 3451: 3437: 3431: 3430: 3428: 3426: 3412: 3406: 3405: 3403: 3401: 3387: 3376: 3375: 3373: 3371: 3357: 3351: 3350: 3348: 3346: 3337:. Archived from 3327: 3321: 3320: 3318: 3316: 3307:. Archived from 3297: 3291: 3290: 3288: 3286: 3264: 3258: 3257: 3255: 3253: 3238: 3177: 3175: 3174: 3164:Andrew Singleton 3160: 3139: 3137: 3136: 3124: 3099: 3097: 3096: 3086: 3074: 3072: 3071: 3061: 3049: 3047: 3046: 3034: 3014: 3012: 3011: 3002: 3000: 2999: 2987: 2970: 2968: 2967: 2955: 2935: 2933: 2932: 2918: 2890: 2888: 2887: 2878: 2876: 2875: 2861: 2841: 2839: 2838: 2824: 2807: 2805: 2804: 2790: 2770: 2768: 2767: 2753: 2736: 2734: 2733: 2723:Anthony A. Hyman 2719: 2691: 2689: 2688: 2674: 2654: 2652: 2651: 2637: 2620: 2618: 2617: 2603: 2583: 2581: 2580: 2571: 2569: 2568: 2554: 2537: 2535: 2534: 2520: 2496: 2494: 2493: 2484: 2482: 2481: 2467: 2447: 2445: 2444: 2434:Jeffery W. Kelly 2430: 2405: 2403: 2402: 2393:Richard J. Youle 2390: 2370: 2368: 2367: 2353: 2329: 2327: 2326: 2317: 2315: 2314: 2300: 2276: 2274: 2273: 2259: 2234: 2232: 2231: 2222: 2220: 2219: 2205: 2185: 2183: 2182: 2168: 2144: 2142: 2141: 2127: 2107: 2105: 2104: 2090: 2066: 2064: 2063: 2049: 2020: 2018: 2017: 2008: 2006: 2005: 1991: 1967: 1965: 1964: 1955: 1953: 1952: 1938: 1914: 1912: 1911: 1902: 1900: 1899: 1885: 1868: 1866: 1865: 1851: 1831: 1829: 1828: 1818:C. Frank Bennett 1814: 1789: 1787: 1786: 1776:Don W. Cleveland 1772: 1752: 1750: 1749: 1735: 1725:Kyoto University 1718: 1716: 1715: 1701: 1677: 1675: 1674: 1665: 1663: 1662: 1648: 1624: 1622: 1621: 1607: 1574: 1572: 1571: 1562: 1560: 1559: 1545: 1521: 1519: 1518: 1508:Yoshinori Ohsumi 1504: 1480: 1478: 1477: 1463: 1443: 1441: 1440: 1426: 1398: 1396: 1395: 1381: 1356: 1354: 1353: 1339: 1315: 1313: 1312: 1298: 1274: 1272: 1271: 1257: 1236: 1234: 1233: 1219: 1199: 1197: 1196: 1186:Edward S. Boyden 1182: 1156: 1154: 1153: 1139: 1111: 1109: 1108: 1094: 1073: 1071: 1070: 1056: 1032: 1030: 1029: 1015: 995: 993: 992: 978: 958: 956: 955: 941: 912: 910: 909: 900: 898: 897: 883: 859: 857: 856: 842: 818: 816: 815: 801: 781: 779: 778: 769: 767: 766: 752: 742:Emory University 732: 730: 729: 715: 687: 685: 684: 674:James P. Allison 670: 641: 639: 638: 624: 606:Kyoto University 592: 590: 589: 575: 551: 549: 548: 534: 510: 508: 507: 493: 469: 467: 466: 452: 432: 430: 429: 420: 418: 417: 403: 379: 377: 376: 367: 365: 364: 350: 326: 324: 323: 309: 281: 279: 278: 268:Lewis C. Cantley 264: 244: 242: 241: 232: 230: 229: 215: 195: 193: 192: 178: 144: 143: 94:in Life Sciences 83: 80: 53: 51: 46: 24: 23: 4442: 4441: 4435: 4434: 4433: 4431: 4430: 4429: 4400:Medicine awards 4390:Academic awards 4380: 4379: 4378: 4373: 4364:Ellen Sidransky 4344:Michel Sadelain 4330:Emmanuel Mignot 4304:David Klenerman 4277: 4267:Catherine Dulac 4179:Harry F. Noller 4157:Karl Deisseroth 4143:Jennifer Doudna 4109:Michael N. Hall 4095:Bert Vogelstein 4091:Shinya Yamanaka 4087:Robert Weinberg 4083:Charles Sawyers 4041: 4018:Gilles Brassard 3998:Steven Weinberg 3980:Eric Adelberger 3890:Yōichirō Suzuki 3802:Saul Perlmutter 3768:Tejinder Virdee 3752:Stephen Hawking 3701: 3694: 3615:Simon Donaldson 3601: 3595: 3558: 3553: 3552: 3546: 3539: 3537: 3525: 3521: 3511: 3509: 3500: 3499: 3495: 3488: 3484: 3474: 3472: 3464: 3463: 3459: 3449: 3447: 3439: 3438: 3434: 3424: 3422: 3414: 3413: 3409: 3399: 3397: 3389: 3388: 3379: 3369: 3367: 3359: 3358: 3354: 3344: 3342: 3329: 3328: 3324: 3314: 3312: 3299: 3298: 3294: 3284: 3282: 3266: 3265: 3261: 3251: 3249: 3239: 3230: 3225: 3198: 3172: 3170: 3166: 3134: 3132: 3128:Ellen Sidransky 3094: 3092: 3069: 3067: 3044: 3042: 3009: 3007: 3006: 2997: 2995: 2965: 2963: 2959:Michel Sadelain 2930: 2928: 2924: 2899: 2885: 2883: 2882: 2873: 2871: 2867: 2836: 2834: 2830: 2828:Emmanuel Mignot 2802: 2800: 2796: 2765: 2763: 2759: 2731: 2729: 2725: 2707: 2703: 2686: 2684: 2680: 2649: 2647: 2643: 2615: 2613: 2609: 2607:David Klenerman 2578: 2576: 2575: 2566: 2564: 2560: 2532: 2530: 2526: 2508: 2491: 2489: 2488: 2479: 2477: 2473: 2442: 2440: 2436: 2400: 2398: 2394: 2365: 2363: 2359: 2341: 2324: 2322: 2321: 2312: 2310: 2306: 2304:Catherine Dulac 2288: 2271: 2269: 2265: 2229: 2227: 2226: 2217: 2215: 2211: 2180: 2178: 2174: 2156: 2139: 2137: 2133: 2102: 2100: 2096: 2078: 2061: 2059: 2055: 2032: 2015: 2013: 2012: 2003: 2001: 1997: 1979: 1962: 1960: 1959: 1950: 1948: 1944: 1909: 1907: 1906: 1897: 1895: 1891: 1863: 1861: 1857: 1826: 1824: 1820: 1784: 1782: 1778: 1747: 1745: 1741: 1713: 1711: 1707: 1689: 1672: 1670: 1669: 1660: 1658: 1654: 1636: 1619: 1617: 1613: 1590: 1586: 1569: 1567: 1566: 1557: 1555: 1551: 1516: 1514: 1510: 1492: 1475: 1473: 1469: 1438: 1436: 1432: 1430:Harry F. Noller 1414: 1410: 1393: 1391: 1387: 1351: 1349: 1345: 1327: 1310: 1308: 1304: 1269: 1267: 1263: 1245: 1231: 1229: 1225: 1223:Karl Deisseroth 1194: 1192: 1188: 1167:Umeå University 1165: 1151: 1149: 1145: 1127: 1123: 1106: 1104: 1100: 1098:Jennifer Doudna 1082: 1068: 1066: 1062: 1027: 1025: 1021: 990: 988: 984: 953: 951: 947: 907: 905: 904: 895: 893: 889: 854: 852: 848: 813: 811: 807: 776: 774: 773: 764: 762: 758: 756:Michael N. Hall 727: 725: 721: 682: 680: 676: 653: 636: 634: 630: 628:Bert Vogelstein 612: 608: 587: 585: 581: 579:Shinya Yamanaka 563: 546: 544: 540: 522: 505: 503: 499: 483:Broad Institute 481: 464: 462: 458: 427: 425: 424: 415: 413: 409: 374: 372: 371: 362: 360: 356: 321: 319: 315: 297: 276: 274: 270: 239: 237: 236: 227: 225: 221: 190: 188: 184: 154: 142: 98:Mark Zuckerberg 77: 49: 47: 44: 22: 17: 12: 11: 5: 4440: 4439: 4428: 4427: 4422: 4417: 4415:Life extension 4412: 4407: 4402: 4397: 4395:Biology awards 4392: 4375: 4374: 4372: 4371: 4352:Paul Negulescu 4337: 4322:Demis Hassabis 4311: 4292:Katalin Karikó 4285: 4260: 4238: 4231:Xiaowei Zhuang 4216: 4205:Kazutoshi Mori 4194: 4172: 4150: 4124: 4098: 4071:Titia de Lange 4059:David Botstein 4051: 4049: 4043: 4042: 4040: 4039: 4029: 4011: 4001: 3991: 3977: 3971: 3960:Sergio Ferrara 3953: 3943: 3933: 3926:Lyman Page Jr. 3922:Norman Jarosik 3911: 3897: 3886:Takaaki Kajita 3843: 3842:project (2016) 3821: 3799: 3789: 3783: 3745: 3734:Nathan Seiberg 3730:Juan Maldacena 3706: 3704: 3696: 3695: 3693: 3692: 3686: 3680: 3674: 3668: 3662: 3656: 3653:James McKernan 3646: 3640: 3634: 3631:Richard Taylor 3611: 3609: 3603: 3602: 3594: 3593: 3586: 3579: 3571: 3565: 3564: 3557: 3556:External links 3554: 3551: 3550: 3519: 3493: 3490:Laureates 2023 3482: 3457: 3432: 3407: 3377: 3352: 3322: 3292: 3259: 3227: 3226: 3224: 3221: 3220: 3219: 3214: 3209: 3204: 3197: 3194: 3191: 3190: 3181: 3179:United Kingdom 3168: 3161: 3153: 3152: 3143: 3130: 3125: 3117: 3116: 3106: 3103: 3090: 3089:Thomas Gasser 3087: 3079: 3078: 3065: 3062: 3054: 3053: 3040: 3038:Paul Negulescu 3035: 3027: 3026: 3021: 3018: 2993: 2988: 2980: 2979: 2974: 2961: 2956: 2948: 2947: 2942: 2939: 2926: 2919: 2912: 2904: 2903: 2894: 2869: 2862: 2854: 2853: 2848: 2845: 2832: 2825: 2817: 2816: 2811: 2798: 2791: 2783: 2782: 2777: 2774: 2772:United Kingdom 2761: 2757:Demis Hassabis 2754: 2746: 2745: 2740: 2738:United Kingdom 2727: 2720: 2712: 2711: 2698: 2695: 2682: 2675: 2668: 2662: 2661: 2658: 2645: 2638: 2630: 2629: 2624: 2622:United Kingdom 2611: 2604: 2596: 2595: 2590: 2587: 2585:United Kingdom 2562: 2555: 2547: 2546: 2541: 2528: 2521: 2513: 2512: 2503: 2500: 2475: 2471:Katalin Karikó 2468: 2460: 2459: 2454: 2451: 2438: 2431: 2424: 2418: 2417: 2412: 2409: 2396: 2391: 2383: 2382: 2377: 2374: 2361: 2354: 2346: 2345: 2336: 2333: 2308: 2301: 2293: 2292: 2283: 2280: 2267: 2260: 2253: 2247: 2246: 2241: 2238: 2213: 2206: 2198: 2197: 2192: 2189: 2176: 2169: 2161: 2160: 2151: 2148: 2135: 2128: 2120: 2119: 2114: 2111: 2098: 2091: 2083: 2082: 2073: 2070: 2057: 2050: 2043: 2037: 2036: 2027: 2024: 1999: 1992: 1984: 1983: 1974: 1971: 1946: 1942:Xiaowei Zhuang 1939: 1931: 1930: 1925: 1918: 1893: 1886: 1878: 1877: 1872: 1859: 1852: 1844: 1843: 1838: 1835: 1822: 1815: 1808: 1802: 1801: 1796: 1793: 1780: 1773: 1765: 1764: 1759: 1756: 1754:United Kingdom 1743: 1736: 1728: 1727: 1722: 1709: 1705:Kazutoshi Mori 1702: 1694: 1693: 1684: 1681: 1656: 1649: 1641: 1640: 1631: 1628: 1615: 1608: 1601: 1595: 1594: 1581: 1578: 1553: 1546: 1538: 1537: 1532: 1525: 1512: 1505: 1497: 1496: 1487: 1484: 1471: 1464: 1456: 1455: 1450: 1447: 1434: 1427: 1419: 1418: 1405: 1402: 1389: 1382: 1375: 1369: 1368: 1363: 1360: 1347: 1340: 1332: 1331: 1322: 1319: 1306: 1299: 1291: 1290: 1285: 1278: 1276:United Kingdom 1265: 1258: 1250: 1249: 1240: 1227: 1220: 1212: 1211: 1206: 1203: 1190: 1183: 1176: 1170: 1169: 1160: 1147: 1140: 1132: 1131: 1118: 1115: 1102: 1095: 1087: 1086: 1077: 1064: 1057: 1049: 1048: 1043: 1036: 1023: 1016: 1008: 1007: 1002: 999: 986: 982:C. David Allis 979: 971: 970: 965: 962: 949: 942: 935: 929: 928: 923: 916: 891: 884: 876: 875: 870: 863: 850: 843: 835: 834: 829: 822: 809: 802: 794: 793: 788: 785: 760: 753: 745: 744: 739: 736: 723: 716: 708: 707: 702: 691: 678: 671: 664: 658: 657: 648: 645: 632: 625: 617: 616: 603: 596: 583: 576: 568: 567: 558: 555: 542: 535: 527: 526: 517: 514: 501: 494: 486: 485: 476: 473: 460: 456:Eric S. Lander 453: 445: 444: 439: 436: 411: 404: 396: 395: 390: 383: 358: 354:Titia de Lange 351: 343: 342: 337: 330: 317: 310: 302: 301: 292: 285: 272: 265: 257: 256: 251: 248: 223: 219:David Botstein 216: 208: 207: 202: 199: 186: 179: 172: 166: 165: 162: 159: 156: 155:(birth/death) 151: 148: 141: 138: 102:Priscilla Chan 85: 84: 75: 71: 70: 67: 63: 62: 59: 55: 54: 41: 37: 36: 33: 29: 28: 20: 15: 9: 6: 4: 3: 2: 4438: 4437: 4426: 4423: 4421: 4418: 4416: 4413: 4411: 4408: 4406: 4403: 4401: 4398: 4396: 4393: 4391: 4388: 4387: 4385: 4369: 4365: 4361: 4360:Thomas Gasser 4357: 4353: 4349: 4348:Sabine Hadida 4345: 4341: 4338: 4335: 4331: 4327: 4323: 4319: 4315: 4312: 4309: 4305: 4301: 4297: 4296:Drew Weissman 4293: 4289: 4286: 4281: 4276: 4272: 4268: 4264: 4261: 4258: 4254: 4250: 4246: 4242: 4239: 4236: 4232: 4228: 4227:Angelika Amon 4224: 4220: 4217: 4214: 4210: 4206: 4202: 4198: 4195: 4192: 4188: 4184: 4183:Roeland Nusse 4180: 4176: 4173: 4170: 4166: 4162: 4158: 4154: 4153:Edward Boyden 4151: 4148: 4144: 4140: 4136: 4135:Victor Ambros 4132: 4128: 4125: 4122: 4118: 4114: 4110: 4106: 4105:Mahlon DeLong 4102: 4099: 4096: 4092: 4088: 4084: 4080: 4076: 4072: 4068: 4064: 4060: 4056: 4053: 4052: 4050: 4048: 4047:Life sciences 4044: 4037: 4033: 4030: 4027: 4026:Peter W. Shor 4023: 4022:David Deutsch 4019: 4015: 4012: 4009: 4005: 4002: 3999: 3995: 3992: 3989: 3988:Blayne Heckel 3985: 3981: 3978: 3975: 3972: 3969: 3965: 3961: 3957: 3954: 3951: 3947: 3944: 3941: 3937: 3934: 3931: 3930:David Spergel 3927: 3923: 3919: 3915: 3912: 3909: 3905: 3901: 3898: 3895: 3891: 3887: 3883: 3879: 3875: 3871: 3867: 3863: 3859: 3858:Atsuto Suzuki 3855: 3854:Daya Bay team 3851: 3847: 3844: 3841: 3837: 3833: 3829: 3828:Ronald Drever 3825: 3822: 3819: 3815: 3811: 3810:Brian Schmidt 3807: 3803: 3800: 3797: 3793: 3792:Michael Green 3790: 3787: 3784: 3781: 3777: 3773: 3772:Guido Tonelli 3769: 3765: 3761: 3757: 3753: 3749: 3746: 3743: 3742:Edward Witten 3739: 3735: 3731: 3727: 3723: 3719: 3718:Alexei Kitaev 3715: 3711: 3708: 3707: 3705: 3703: 3697: 3690: 3689:Simon Brendle 3687: 3684: 3681: 3678: 3675: 3672: 3671:Martin Hairer 3669: 3666: 3663: 3660: 3657: 3654: 3650: 3647: 3644: 3643:Jean Bourgain 3641: 3638: 3635: 3632: 3628: 3624: 3620: 3616: 3613: 3612: 3610: 3608: 3604: 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June 2910: 2907: 2665: 2641:Pascal Mayer 2421: 2250: 2172:David Julius 2040: 1892:(1967–2020) 1805: 1652:Peter Walter 1611:Joanne Chory 1598: 1372: 1343:Svante Pääbo 1173: 985:(1951–2023) 932: 867:hypertension 826:biomaterials 768:   661: 313:Hans Clevers 231:   169: 164:Affiliation 122: 90: 88: 18: 4425:Yuri Milner 4326:John Jumper 4278: [ 4263:David Baker 4209:Kim Nasmyth 4191:Huda Zoghbi 4165:Helen Hobbs 4139:Gary Ruvkun 4079:Eric Lander 3950:Eugene Mele 3908:Cumrun Vafa 3896:team (2016) 3850:Kam-Biu Luk 3846:Yifang Wang 3756:Peter Jenni 3700:Fundamental 3627:Terence Tao 3623:Jacob Lurie 3607:Mathematics 3540:October 15, 3475:October 15, 3450:October 15, 3425:October 15, 3400:October 15, 3370:October 15, 2794:John Jumper 2660:Alphanosos 2263:David Baker 1739:Kim Nasmyth 1549:Huda Zoghbi 1482:Netherlands 1302:Helen Hobbs 1060:Gary Ruvkun 771:Switzerland 697:checkpoint 369:Netherlands 328:Netherlands 289:PI 3-Kinase 234:Switzerland 110:Yuri Milner 106:Sergey Brin 61:$ 3 million 32:Awarded for 4384:Categories 4161:John Hardy 4032:John Cardy 3832:Kip Thorne 3814:Adam Riess 3778:(CMS) and 3738:Ashoke Sen 3665:Alex Eskin 3315:October 2, 3223:References 3167:(b. 1972) 2925:(b. 1953) 2868:(b. 1960) 2831:(b. 1959) 2760:(b. 1976) 2726:(b. 1962) 2644:(b. 1963) 2610:(b. 1959) 2561:(b. 1966) 2527:(b. 1958) 2474:(b. 1955) 2437:(b. 1960) 2395:(b. 1952) 2360:(b. 1963) 2307:(b. 1963) 2266:(b. 1962) 2212:(b. 1945) 2175:(b. 1955) 2134:(b. 1951) 2097:(b. 1957) 2056:(b. 1954) 1998:(b. 1966) 1945:(b. 1972) 1922:aneuploidy 1858:(b. 1958) 1821:(b. 1960) 1779:(b. 1950) 1742:(b. 1952) 1708:(b. 1958) 1655:(b. 1954) 1614:(b. 1955) 1552:(b. 1954) 1511:(b. 1945) 1470:(b. 1950) 1433:(b. 1939) 1388:(b. 1956) 1346:(b. 1955) 1305:(b. 1952) 1264:(b. 1954) 1261:John Hardy 1226:(b. 1971) 1189:(b. 1979) 1146:(b. 1968) 1101:(b. 1964) 1063:(b. 1952) 1022:(b. 1953) 948:(b. 1942) 890:(b. 1946) 849:(b. 1953) 808:(b. 1948) 759:(b. 1953) 722:(b. 1938) 677:(b. 1948) 631:(b. 1949) 582:(b. 1962) 541:(b. 1942) 500:(b. 1959) 459:(b. 1957) 410:(b. 1956) 357:(b. 1955) 316:(b. 1957) 271:(b. 1949) 222:(b. 1942) 185:(b. 1961) 161:Rationale 50:2013-02-20 4340:Carl June 4271:Dennis Lo 3780:Lyn Evans 3762:(ATLAS), 3714:Alan Guth 3600:laureates 3280:0013-0613 2372:Hong Kong 1529:autophagy 1040:microRNAs 387:telomeres 150:Portrait 140:Laureates 58:Reward(s) 3892:and the 3880:and the 3868:and the 3860:and the 3852:and the 3637:Ian Agol 3285:July 10, 3196:See also 2814:DeepMind 2780:DeepMind 2506:BioNTech 699:blockade 158:Country 153:Laureate 3994:Special 3956:Special 3936:Special 3862:KamLAND 3824:Special 3748:Special 3702:physics 3101:Germany 2797:(b. -) 2681:(b. -) 2486:Hungary 2109:Germany 1904:Austria 1667:Germany 1564:Lebanon 926:Caltech 118:23andMe 74:Website 48: ( 4370:(2024) 4336:(2023) 4310:(2022) 4284:(2021) 4259:(2020) 4237:(2019) 4215:(2018) 4193:(2017) 4171:(2016) 4149:(2015) 4123:(2014) 4097:(2013) 4038:(2024) 4028:(2023) 4010:(2022) 4008:Jun Ye 4000:(2021) 3990:(2021) 3976:(2020) 3970:(2019) 3952:(2019) 3942:(2018) 3932:(2018) 3910:(2017) 3884:team, 3876:team, 3864:team, 3820:(2015) 3798:(2014) 3788:(2013) 3744:(2012) 3691:(2024) 3685:(2023) 3679:(2022) 3673:(2021) 3667:(2020) 3661:(2019) 3655:(2018) 3645:(2017) 3639:(2016) 3633:(2015) 3278:  3176:  3138:  3098:  3073:  3048:  3013:  3001:  2972:France 2969:  2934:  2889:  2877:  2840:  2806:  2769:  2735:  2690:  2656:France 2653:  2619:  2582:  2570:  2536:  2495:  2483:  2446:  2404:  2369:  2328:  2319:France 2316:  2275:  2233:  2221:  2184:  2143:  2106:  2065:  2019:  2007:  1966:  1954:  1913:  1901:  1867:  1830:  1788:  1751:  1717:  1676:  1664:  1623:  1573:  1561:  1520:  1479:  1442:  1397:  1358:Sweden 1355:  1314:  1273:  1235:  1198:  1158:France 1155:  1110:  1072:  1031:  994:  960:France 957:  911:  902:Russia 899:  858:  817:  780:  731:  695:T cell 686:  640:  591:  550:  509:  468:  431:  419:  378:  366:  325:  280:  243:  194:  132:, and 112:; and 4282:] 3004:Spain 2880:Japan 2573:India 2224:China 2010:China 1957:China 1720:Japan 1523:Japan 598:"for 594:Japan 422:Italy 147:Year 21:Award 4366:and 4306:and 4221:and 4167:and 4145:and 4119:and 4093:and 4034:and 4006:and 3986:and 3948:and 3888:and 3840:LIGO 3794:and 3629:and 3542:2021 3514:2023 3477:2021 3452:2021 3427:2021 3402:2021 3372:2021 3347:2014 3317:2014 3287:2024 3276:ISSN 3254:2013 3112:and 2908:2024 2666:2023 2422:2022 2251:2021 2041:2020 1806:2019 1599:2018 1373:2017 1174:2016 933:2015 662:2014 170:2013 100:and 89:The 81:.org 69:2013 40:Date 3874:T2K 3870:K2K 3188:NIH 3150:NIH 922:." 869:." 828:." 602:." 4386:: 4362:, 4358:, 4354:, 4350:, 4346:, 4342:, 4332:, 4328:, 4324:, 4320:, 4316:, 4302:, 4298:, 4294:, 4290:, 4280:de 4273:, 4269:, 4265:, 4255:, 4251:, 4247:, 4243:, 4233:, 4229:, 4225:, 4211:, 4207:, 4203:, 4199:, 4189:, 4185:, 4181:, 4177:, 4163:, 4159:, 4155:, 4141:, 4137:, 4133:, 4129:, 4115:, 4111:, 4107:, 4103:, 4089:, 4085:, 4081:, 4077:, 4073:, 4069:, 4065:, 4061:, 4057:, 4024:, 4020:, 4016:, 3996:: 3982:, 3966:, 3962:, 3958:: 3938:: 3928:, 3924:, 3920:, 3916:, 3906:, 3902:, 3872:/ 3856:, 3848:, 3834:, 3830:, 3826:: 3812:, 3808:; 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Index

breakthroughprizeinlifesciences.org
Breakthrough Prize
Mark Zuckerberg
Priscilla Chan
Sergey Brin
Yuri Milner
Anne Wojcicki
23andMe
University of California, Berkeley
University of California, San Francisco
Stanford University

Cornelia Bargmann
United States
Rockefeller University

David Botstein
Switzerland
United States
Princeton University

Lewis C. Cantley
United States
PI 3-Kinase
Harvard Medical School
Weill Cornell Medical College

Hans Clevers
Netherlands
Wnt signaling

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