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Plasma proteins are separated by using the inherent differences of each protein. Fractionation involves changing the conditions of the pooled plasma (e.g., the temperature or the acidity) so that proteins that are normally dissolved in the plasma fluid become insoluble, forming large clumps, called
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containing a silicone gel; when centrifuged the silicone gel forms a layer on top of the buffy coat, allowing the blood serum to be removed more effectively for testing and related purposes.
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As an alternative to energy-consuming centrifugation, more energy-efficient technologies have been studied, such as ultrasonic fractionation.
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becomes isolated from the red blood cells by a gel acting as a physical barrier to prevent inadvertent remixing of the components.
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275:"Experimental setup for the ultrasonic fractionation of flowing whole blood in a capillary"
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Smalberger C, Nathan M, Rubin DM, Nel M, Kotopoulis S, Carlson CS, Postema M (2022).
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fractionation. It was described by and bears the eponym of Dr
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precipitate. The insoluble protein can be collected by
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320:(before the U.S. Congress, July 31, 1997) (via
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279:Current Directions in Biomedical Engineering
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16:Separation of blood into its components
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