1733:
461:
42:
1747:
1719:
6808:
1549:
4699:
Safrin S, Finkelstein DM, Feinberg J, Frame P, Simpson G, Wu A, et al. (May 1996). "Comparison of three regimens for treatment of mild to moderate
Pneumocystis carinii pneumonia in patients with AIDS. A double-blind, randomized, trial of oral trimethoprim-sulfamethoxazole, dapsone-trimethoprim,
2998:
An extensive systematic review of sulfonamide usage near term and during breastfeeding found no side effects in infants; the authors concluded that use of this combination drug during breastfeeding presents no risk of neonatal kernicterus... LactMed: Use is considered acceptable when breastfeeding
1603:
The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in
4047:"Activities of clindamycin, daptomycin, doxycycline, linezolid, trimethoprim-sulfamethoxazole, and vancomycin against community-associated methicillin-resistant Staphylococcus aureus with inducible clindamycin resistance in murine thigh infection and in vitro pharmacodynamic models"
1148:), urinary tract defects, oral clefts, and club foot in epidemiological studies. Its use later on during pregnancy also increases the risk of preterm labour (odds ratio: 1.51) and low birth weight (odds ratio: 1.67). Animal studies have yielded similarly discouraging results.
1136:) and 12 weeks prior to pregnancy has been associated with an increased risk of congenital malformations, especially malformations associated with maternal folic acid deficiency (which is most likely related to the mechanism of action of co-trimoxazole) such as
1565:
pathway. They are given in a one-to-five ratio in their tablet formulations so that when they enter the body their concentration in the blood and tissues is roughly one-to-twenty — the exact ratio required for a peak synergistic effect between the two.
3312:
2604:
1560:
between trimethoprim and sulfamethoxazole was first described in the late 1960s. Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the
3122:
Gentry CA, Nguyen AT (December 2013). "An evaluation of hyperkalemia and serum creatinine elevation associated with different dosage levels of outpatient trimethoprim-sulfamethoxazole with and without concomitant medications".
3538:
Ericsson CD, Johnson PC, Dupont HL, Morgan DR, Bitsura JA, de la Cabada FJ (February 1987). "Ciprofloxacin or trimethoprim-sulfamethoxazole as initial therapy for travelers' diarrhea. A placebo-controlled, randomized trial".
613:
3998:"Prospective randomized trial of empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus"
3773:"Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial"
3650:
Nordin K, Hallander H, Fredriksson T, Rylander C (1978). "A clinical and bacteriological evaluation of the effect of sulphamethoxazole-trimethoprim in acne vulgaris, resistant to prior therapy with tetracyclines".
1988:
Generally accepted treatment for shigellosis. A recent
Cochrane review found that while it is an effective treatment for shigellosis it also produces more significant adverse effects than other antibiotic drugs.
3440:
van der Veen EL, Rovers MM, Albers FW, Sanders EA, Schilder AG (May 2007). "Effectiveness of trimethoprim/sulfamethoxazole for children with chronic active otitis media: a randomized, placebo-controlled trial".
3686:
Chetchotisakd P, Chaowagul W, Mootsikapun P, Budhsarawong D, Thinkamrop B (January 2001). "Maintenance therapy of melioidosis with ciprofloxacin plus azithromycin compared with cotrimoxazole plus doxycycline".
3494:
Leiberman A, Leibovitz E, Piglansky L, Raiz S, Press J, Yagupsky P, et al. (March 2001). "Bacteriologic and clinical efficacy of trimethoprim-sulfamethoxazole for treatment of acute otitis media".
4656:
Agrawal AK, Chang PP, Feusner J (January 2011). "Twice weekly
Pneumocystis jiroveci pneumonia prophylaxis with trimethoprim-sulfamethoxazole in pediatric patients with acute lymphoblastic leukemia".
3308:
1436:— patients who have received a kidney transplant and are receiving co-trimoxazole and ciclosporin concomitantly are at an increased risk of having a reversible deterioration in their kidney function.
4229:"Daptomycin-nonsusceptible vancomycin-intermediate staphylococcus aureus vertebral osteomyelitis cases complicated by bacteremia treated with high-dose daptomycin and trimethoprim-sulfamethoxazole"
2408:
3953:
Grim SA, Rapp RP, Martin CA, Evans ME (February 2005). "Trimethoprim-sulfamethoxazole as a viable treatment option for infections caused by methicillin-resistant
Staphylococcus aureus".
1442:— concurrent use can increase the likelihood of hyperkalemia, especially in the elderly. The trimethoprim portion acts to prevent potassium excretion in the distal tubule of the nephron.
2826:
4788:"Randomized trial of trimethoprim-sulfamethoxazole versus pyrimethamine-sulfadiazine for therapy of toxoplasmic encephalitis in patients with AIDS. Italian Collaborative Study Group"
263:
3574:
Ericsson CD, DuPont HL, Mathewson JJ, West MS, Johnson PC, Bitsura JA (January 1990). "Treatment of traveler's diarrhea with sulfamethoxazole and trimethoprim and loperamide".
3285:
2434:
4094:
Pappas G, Athanasoulia AP, Matthaiou DK, Falagas ME (April 2009). "Trimethoprim-sulfamethoxazole for methicillin-resistant
Staphylococcus aureus: a forgotten alternative?".
2504:
4327:"The combination of sulfamethoxazole, trimethoprim, and isoniazid or rifampin is bactericidal and prevents the emergence of drug resistance in Mycobacterium tuberculosis"
5503:
2772:
Wormser GP, Keusch GT, Heel RC (December 1982). "Co-trimoxazole (trimethoprim-sulfamethoxazole): an updated review of its antibacterial activity and clinical efficacy".
1600:
Tetrahydrofolate is crucial in the synthesis of purines, thymidine, and methionine which are needed for the production of DNA and proteins during bacterial replication.
2888:"Exposure to trimethoprim/sulfamethoxazole but not other FDA category C and D anti-infectives is associated with increased risks of preterm birth and low birth weight"
2737:
6097:
5498:
6858:
5299:
1607:
Co-trimoxazole was claimed to be more effective than either of its components individually in treating bacterial infections, although this was later disputed.
3019:
2221:
1366:, folic acid supplementation should be considered. A significant risk of megaloblastic anaemia exists with doses of pyrimethamine in excess of 25 mg/wk.
1172:
208:
4743:
Canessa A, Del Bono V, De Leo P, Piersantelli N, Terragna A (February 1992). "Cotrimoxazole therapy of
Toxoplasma gondii encephalitis in AIDS patients".
1752:
1452:
Laboratory tests — trimethoprim and sulfonamides have been reported to interfere with diagnostic tests, including serum-methotrexate and elevated serum
1132:
Its use during pregnancy is contraindicated, although it has been placed in
Australian pregnancy category C. Its use during the first trimester (during
5145:
1579:(that is, from within the cell) synthesis of folate inside microbial organisms such as protozoa, fungi and bacteria. It does this by competing with
2696:
2400:
6828:
5448:
3346:
Brumfitt W, Hamilton-Miller JM (December 1993). "Reassessment of the rationale for the combinations of sulphonamides with diaminopyrimidines".
2985:
2320:
6853:
5076:
4139:"Co-trimoxazole versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteraemia: a retrospective cohort study"
3882:
2815:
2561:
The selection and use of essential medicines 2023: web annex A: World Health
Organization model list of essential medicines: 23rd list (2023)
116:
6174:
475:
6090:
4180:"Dose of trimethoprim-sulfamethoxazole to treat skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus"
2019:
516:
153:
2690:
2588:
3277:
3250:
Böhni E (November 1969). "Chemotherapeutic activity of the combination of trimethoprim and sulphamethoxazole in infections of mice".
5105:
3095:
Juvet T, Gourineni VC, Ravi S, Zarich SW (September 2013). "Life-threatening hyperkalemia: a potentially lethal drug combination".
2430:
2496:
2471:
2365:
1540:
Alkalinisation of the urine may reduce the toxicity of sulfamethoxazole, but it may increase the toxic effects of trimethoprim.
6083:
3383:"Effect of co-trimoxazole prophylaxis on morbidity, mortality, CD4-cell count, and viral load in HIV infection in rural Uganda"
6075:
6762:
6041:
5138:
3079:
3054:
2634:
2598:
555:
3869:
Sureshbabu J, Venugopalan P, Abuhammour W (25 June 2012). Fennelly G, Windle ML, Lutwick LI, Tolan Jr RW, Steele RW (eds.).
2929:"Exposure to anti-infective drugs during pregnancy and the risk of small-for-gestational-age newborns: a case-control study"
6848:
5252:
4599:"Safety and efficacy of co-trimoxazole for treatment and prevention of Plasmodium falciparum malaria: a systematic review"
2729:
6843:
5047:
6838:
575:
6405:
5197:
3330:
2540:
6833:
6779:
6058:
5341:
5131:
3011:
1738:
750:
594:
2187:(BAN) Co-trimoxazole is used for trimethoprim/sulfamethoxazole manufactured and sold by many different companies.
248:
134:
6634:
3418:
1194:
5930:
4374:
Alsaad N, van Altena R, Pranger AD, van
Soolingen D, de Lange WC, van der Werf TS, et al. (August 2013).
2183:
Trimethoprim/sulfamethoxazole may be abbreviated as SXT, SMZ-TMP, TMP-SMX, TMP-SMZ, or TMP-sulfa. The generic
5747:
5633:
3771:
Chetchotisakd P, Chierakul W, Chaowagul W, Anunnatsiri S, Phimda K, Mootsikapun P, et al. (March 2014).
2140:
5699:
5576:
5262:
5017:
5977:
5369:
2240:
1724:
1006:
999:
524:
5819:
1096:
440:
5123:
2684:
2497:"Bactrim DS- sulfamethoxazole and trimethoprim tablet Bactrim- sulfamethoxazole and trimethoprim tablet"
2070:
Co-trimoxazole is the recommended standard treatment for whipple's disease in some treatment protocols.
429:
6798:
4878:"Cotrimoxazole for treatment of cerebral toxoplasmosis: an observational cohort study during 1994-2006"
4550:"Isosporiasis in patients with HIV infection in the highly active antiretroviral therapy era in France"
4548:
Lagrange-Xélot M, Porcher R, Sarfati C, de Castro N, Carel O, Magnier JD, et al. (February 2008).
1163:
Its use in those less than 2 months of age is not recommended due to the risk of adverse side effects.
992:
859:
562:. In 2021, it was the 122nd most commonly prescribed medication in the United States, with more than 4
6478:
4927:"Treatment of toxoplasmic lymphadenitis with co-trimoxazole: double-blind, randomized clinical trial"
2981:
2556:
2312:
730:
2656:
5493:
2172:
Clinical trials have confirmed its prophylactic and therapeutic utility in cases of toxoplasmosis.
1845:
1840:
Clinical trials have confirmed its efficacy in chronic active otitis media and acute otitis media.
1321:(as it may lead to an increased plasma level of rifampicin and lower plasma levels of trimethoprim)
1020:
1013:
903:
636:
pneumonia is still a substantial public health problem. Most of what is scientifically known about
512:
456:
5069:
3870:
1221:
Known hypersensitivity to trimethoprim, sulphonamides or any other ingredients in the formulations
6767:
6629:
6606:
6373:
6046:
5554:
3311:. In Grayson ML, Cosgrove S, Crowe S, Hope W, McCarthy J, Mills J, Mouton JW, Paterson D (eds.).
1865:
1590:
1077:
811:
190:
89:
74:
17:
4876:
Béraud G, Pierre-François S, Foltzer A, Abel S, Liautaud B, Smadja D, et al. (April 2009).
4178:
Cadena J, Nair S, Henao-Martinez AF, Jorgensen JH, Patterson JE, Sreeramoju PV (December 2011).
3724:"Outcomes of patients with melioidosis treated with cotrimoxazole alone for eradication therapy"
1241:(CrCl <15 ml/min) where repeated measurements of the plasma concentration cannot be performed
574:
Trimethoprim/sulfamethoxazole generally kills bacteria, by blocking the microorganisms' ability
6617:
6493:
6449:
6165:
6105:
5402:
5247:
5158:
2139:
Its use as a prophylactic treatment is supported by one clinical trial involving children with
2122:
1626:
1238:
1116:
1106:
1034:
1027:
910:
883:
833:
629:
532:
520:
493:
62:
4466:"Whipple's disease in Spain: a clinical review of 91 patients diagnosed between 1947 and 2001"
33:
6623:
5325:
5321:
5205:
2196:
2184:
2117:
Clinical trials have confirmed its efficacy in both the treatment and prevention of malaria.
1995:
985:
888:
871:
845:
818:
409:
103:
4837:"Trimethoprim-sulfamethoxazole as toxoplasmosis prophylaxis for heart transplant recipients"
4713:
369:
6543:
5624:
5548:
4610:
2056:
1145:
1058:
1053:
938:
931:
711:
691:
548:
4835:
Muñoz P, Arencibia J, Rodríguez C, Rivera M, Palomo J, Yañez J, et al. (April 2003).
324:
8:
6744:
6110:
5674:
5101:
4276:
Forgacs P, Wengenack NL, Hall L, Zimmerman SK, Silverman ML, Roberts GD (November 2009).
3381:
Mermin J, Lule J, Ekwaru JP, Malamba S, Downing R, Ransom R, et al. (October 2004).
1580:
1290:
1137:
852:
718:
684:
617:
544:
500:
315:
197:
4614:
4518:
3846:
3821:
1527:
Haemodialysis, which is moderately effective in clearing co-trimoxazole from the plasma.
1426:— elderly patients receiving thiazide diuretics are at a heightened risk for developing
460:
6716:
6523:
6305:
6208:
5925:
5397:
4994:
4967:
4907:
4768:
4725:
4681:
4633:
4579:
4530:
4351:
4326:
4302:
4277:
4253:
4228:
4204:
4179:
4119:
4071:
4046:
4022:
3997:
3978:
3930:
3905:
3797:
3772:
3748:
3723:
3520:
3476:
3410:
3192:
3183:
3167:
3148:
3043:
2958:
2797:
559:
164:
4812:
4787:
4786:
Torre D, Casari S, Speranza F, Donisi A, Gregis G, Poggio A, et al. (June 1998).
4137:
Goldberg E, Paul M, Talker O, Samra Z, Raskin M, Hazzan R, et al. (August 2010).
3788:
3398:
2590:
Lewis's
Medical-Surgical Nursing EBook: Assessment and Management of Clinical Problems
2361:
593:
Trimethoprim/sulfamethoxazole (TMP/SMX) is the medicine most commonly used to prevent
126:
6254:
6190:
5181:
4999:
4948:
4899:
4858:
4817:
4760:
4717:
4673:
4638:
4571:
4566:
4549:
4522:
4487:
4446:
4441:
4416:
4397:
4356:
4307:
4258:
4209:
4160:
4111:
4076:
4027:
3970:
3935:
3851:
3802:
3753:
3704:
3668:
3632:
3591:
3587:
3556:
3512:
3508:
3468:
3402:
3363:
3326:
3259:
3232:
3197:
3140:
3104:
3075:
3050:
2950:
2945:
2928:
2909:
2868:
2801:
2789:
2785:
2594:
2536:
2463:
2205:
Bibactin (manufactured by PPM and distributed in Cambodia and some African countries)
1860:
Clinical trials have confirmed its efficacy as a treatment for travellers' diarrhea.
1575:
1427:
1190:
1041:
917:
742:
300:
287:
275:
4911:
4772:
4729:
4685:
4583:
4534:
4482:
4465:
3982:
3524:
3480:
3414:
3152:
2962:
2143:. Other than this and one other clinical trial into its efficacy as a treatment for
41:
6312:
6291:
5670:
5377:
5349:
4989:
4979:
4938:
4889:
4848:
4807:
4799:
4752:
4709:
4665:
4628:
4618:
4561:
4514:
4477:
4436:
4428:
4387:
4376:"Evaluation of co-trimoxazole in the treatment of multidrug-resistant tuberculosis"
4346:
4338:
4297:
4289:
4248:
4240:
4199:
4191:
4150:
4123:
4103:
4066:
4058:
4017:
4009:
3962:
3925:
3921:
3917:
3841:
3837:
3833:
3792:
3784:
3743:
3735:
3696:
3660:
3622:
3583:
3548:
3504:
3458:
3450:
3394:
3359:
3355:
3318:
3224:
3187:
3179:
3132:
2940:
2899:
2860:
2781:
2564:
2257:
2230:
Graprima Forte Kaplet (manufactured by PT Graha Farma and distributed in Indonesia)
1650:
1562:
1530:
1446:
1363:
945:
924:
781:
508:
349:
231:
221:
77:
57:
3996:
Cenizal MJ, Skiest D, Luber S, Bedimo R, Davis P, Fox P, et al. (July 2007).
2626:
6812:
6680:
5566:
5392:
4669:
4623:
4598:
4464:
Ojeda E, Cosme A, Lapaza J, Torrado J, Arruabarrena I, Alzate L (February 2010).
2864:
2464:"Co-Trimoxazole 80 mg/400 mg Tablets - Summary of Product Characteristics (SmPC)"
2261:
1969:
One cochrane review supports its efficacy in preventing the spread of pertussis.
1295:
1084:
1065:
5166:
5162:
3966:
3552:
648:
Organisms against which trimethoprim/sulfamethoxazole can be effective include:
6773:
6432:
6283:
6114:
6052:
5939:
5809:
5609:
5604:
5594:
5458:
5453:
5417:
5275:
4943:
4926:
3739:
2904:
2887:
1808:
1804:
1746:
1439:
1411:
1089:
957:
6272:
5039:
4894:
4877:
4432:
4392:
4375:
4107:
6822:
6748:
6413:
6216:
6106:
5907:
5857:
5847:
5805:
5795:
5785:
5717:
5641:
5599:
5519:
5443:
5412:
5331:
5317:
5305:
5295:
5289:
5285:
5280:
5270:
5225:
4596:
3700:
3685:
3136:
2156:
1893:
1812:
1718:
1351:
1335:
1329:
1280:
1256:
1205:
1152:
1133:
1046:
950:
676:
654:
621:
605:
536:
4984:
6734:
6720:
6569:
6549:
6382:
6368:
6245:
6221:
6179:
6155:
6118:
5862:
5852:
5837:
5827:
5800:
5780:
5775:
5770:
5765:
5760:
5755:
5737:
5732:
5727:
5722:
5712:
5707:
5666:
5661:
5463:
5354:
5235:
5003:
4952:
4903:
4862:
4677:
4642:
4575:
4526:
4491:
4450:
4401:
4360:
4311:
4262:
4213:
4164:
4115:
4080:
4031:
3974:
3939:
3855:
3806:
3757:
3708:
3636:
3516:
3472:
3454:
3406:
3144:
3108:
2954:
2913:
2872:
2851:
Harik NS (July 2013). "Tularemia: epidemiology, diagnosis, and treatment".
2084:
2030:
1824:
1672:
1407:
1394:
may have their plasma concentrations increased bilaterally or unilaterally.
1387:
1359:
1141:
864:
796:
773:
765:
504:
226:
216:
69:
4821:
4803:
4764:
4721:
3770:
3595:
3560:
3367:
3322:
3263:
3236:
3201:
2793:
6688:
6598:
6574:
6559:
6554:
6508:
6457:
6418:
6326:
6300:
6295:
6226:
6149:
6138:
6023:
6015:
5995:
5948:
5882:
5842:
5790:
5679:
5529:
5468:
5422:
5382:
5359:
5230:
5210:
5154:
5153:
4342:
4293:
4244:
4195:
4155:
4138:
4062:
4013:
3672:
3074:(2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust.
1974:
1946:
1931:
1570:
1433:
1377:
1347:
1332:— anticoagulant effects of either drug is potentiated by this combination
1314:
1272:
838:
788:
757:
735:
670:
201:
2569:
1945:
Clinical trials have confirmed its efficacy, with or without adjunctive
1400:
and other antipsychotics — increased risk of haematological side effects
6611:
6539:
6518:
6503:
6396:
6342:
6316:
6231:
5985:
5911:
5898:
5887:
5832:
5689:
5684:
5656:
5589:
5559:
5407:
5220:
5175:
4756:
1816:
1597:
synthesis of tetrahydrofolate, the biologically active form of folate.
1453:
1403:
1391:
1381:
1373:
1369:
1318:
1303:
1299:
1286:
1268:
1251:
Its use is advised against in people being concomitantly treated with:
1121:
1111:
962:
876:
825:
579:
496:
360:
3722:
Chusri S, Hortiwakul T, Charoenmak B, Silpapojakul K (November 2012).
3721:
3664:
3463:
3228:
2982:"Sulfamethoxazole / trimethoprim Pregnancy and Breastfeeding Warnings"
2927:
Santos F, Sheehy O, Perreault S, Ferreira E, Berard A (October 2011).
2253:
Sanprima (manufactured by PT Sanbe Farma and distributed in Indonesia)
1548:
640:
pneumonia and its treatment comes from studying people with HIV/AIDS.
6564:
6513:
6462:
6437:
6426:
6352:
6321:
6127:
6005:
6000:
5990:
5972:
5646:
5614:
5584:
5534:
5387:
5310:
4547:
1954:
1732:
1423:
1397:
1355:
1341:
1264:
1260:
1231:
1201:
696:
662:
335:
120:
4373:
4227:
Avery LM, Steed ME, Woodruff AE, Hasan M, Rybak MJ (November 2012).
3382:
2295:
Trimethoprim/sulfamethoxazole is relatively inexpensive as of 2019.
5651:
5438:
5215:
5070:"Septran/Sepman Double Strength - Co-Trimoxazole Oral Formulations"
4968:"Successful treatment of cerebral toxoplasmosis with cotrimoxazole"
4853:
4836:
4745:
European Journal of Clinical Microbiology & Infectious Diseases
4045:
LaPlante KL, Leonard SN, Andes DR, Craig WA, Rybak MJ (June 2008).
3904:
Christopher PR, David KV, John SM, Sankarapandian V (August 2010).
3627:
3610:
2244:
2147:
pneumonia, data on its use in both the treatment and prevention of
1912:
1325:
1276:
1227:
Severe liver failure, marked liver parenchymal damage, or jaundice.
1186:
1182:
977:
969:
895:
803:
723:
703:
609:
540:
389:
148:
4597:
Manyando C, Njunju EM, D'Alessandro U, Van Geertruyden JP (2013).
4093:
3903:
3649:
6706:
6347:
5524:
4742:
4177:
2886:
Yang J, Xie RH, Krewski D, Wang YJ, Walker M, Wen SW (May 2011).
2103:
1907:
At least one clinical trial supports its use in this indication.
1557:
1417:
1310:
1070:
528:
4875:
3819:
3309:"Trimethoprim and Trimethoprim–Sulfamethoxazole (Cotrimoxazole)"
1879:
Clinical trials have confirmed its efficacy in this indication.
1420:— increase in digoxin levels in a proportion of elderly patients
3868:
3493:
3439:
1800:
1492:
1178:
420:
6596:
4698:
4834:
4275:
2926:
2431:"TGA eBS - Product and Consumer Medicine Information Licence"
400:
3820:
Altunaiji S, Kukuruzovic R, Curtis N, Massie J (July 2007).
445:
3573:
3537:
2098:
Clinical trials have confirmed its use in this indication.
1764:
380:
2533:
Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition
2051:
activity against both nonresistant and MDR strains of TB.
1573:, induces its therapeutic effects by interfering with the
1456:
levels, also urea, urinary glucose and urobilinogen tests.
5962:
5938:
4785:
4044:
3040:
2586:
2555:
1784:
1204:
is not recommended. It appears to be safe for use during
4972:
Indian Journal of Sexually Transmitted Diseases and AIDS
3995:
3094:
2657:"Sulfamethoxazole; Trimethoprim - Drug Usage Statistics"
1445:
Potassium aminobenzoate — effects of sulfonamides (like
4463:
4226:
4136:
3608:
3380:
3345:
556:
World Health Organization's List of Essential Medicines
543:
and other causes of immunosuppression. It can be given
5040:"Novo-Trimel Advanced Patient Information - Drugs.com"
4966:
Patil HV, Patil VC, Rajmane V, Raje V (January 2011).
2313:"Sulfamethoxazole / trimethoprim Use During Pregnancy"
1234:(due to the sulfonamide component of the preparation).
614:
corticosteroid,mono clonal antibody,immunosuppressants
604:
pneumonia have a medical condition that weakens their
6796:
4965:
4882:
The American Journal of Tropical Medicine and Hygiene
3728:
The American Journal of Tropical Medicine and Hygiene
3689:
The American Journal of Tropical Medicine and Hygiene
2458:
2456:
2454:
2452:
2364:. The American Society of Health-System Pharmacists.
1380:(increased plasma concentrations of zalcitabine) and
1173:
List of side effects of trimethoprim/sulfamethoxazole
531:, among others. It is used both to treat and prevent
4700:and clindamycin-primaquine. ACTG 108 Study Group".
4655:
3952:
2999:
healthy, full-term infants after the newborn period
2825:. Louisiana Office of Public Health. 17 July 2011.
2491:
2489:
1949:; although, co-trimoxazole alone seems preferable.
585:
5102:"SEPTRIN FORTE Comp. 800/160 mg - Datos generales"
3042:
2885:
2449:
2305:
1589:Trimethoprim serves as a competitive inhibitor of
1362:increase the risk of associated side effects like
3049:(65 ed.). London, UK: Pharmaceutical Press.
2771:
2587:Brown D, Edwards H, Buckley T, Aitken RL (2019).
2190:The following list of brand names is incomplete:
1514:The recommended treatment for overdose includes:
1376:(increased plasma concentrations of lamivudine),
6820:
4505:Puéchal X (November 2013). "Whipple's disease".
4278:"Tuberculosis and trimethoprim-sulfamethoxazole"
3317:(7th ed.). CRC Press. pp. 1625, 1634.
3172:British Journal of Pharmacology and Chemotherapy
2486:
1302:(increased risk of ventricular arrhythmias) and
348:
46:Trimethoprim (top) and sulfamethoxazole (bottom)
3306:
3165:
1127:
323:
4414:
4324:
2535:. Jones & Bartlett Learning. p. 105.
2285:Vactrim (manufactured and distributed in Laos)
1104:The only notable nonsusceptible organisms are
624:. People with HIV/AIDS are less likely to get
6859:World Health Organization essential medicines
6091:
5139:
4421:Clinical and Diagnostic Laboratory Immunology
1586:(PABA) in the biosynthesis of dihydrofolate.
4931:International Journal of Infectious Diseases
4541:
3822:"Antibiotics for whooping cough (pertussis)"
3609:Rendi-Wagner P, Kollaritsch H (March 2002).
3121:
3088:
2892:International Journal of Infectious Diseases
1384:(increased risk of haematological reactions)
1306:(increased risk of QT interval prolongation)
152:
5032:
4470:Revista Espanola de Enfermedades Digestivas
3910:The Cochrane Database of Systematic Reviews
3906:"Antibiotic therapy for Shigella dysentery"
3826:The Cochrane Database of Systematic Reviews
3115:
2976:
2974:
2972:
2582:
2580:
1926:Well-designed clinical trials are lacking.
1414:— increased risk of haematological toxicity
517:methicillin-resistant Staphylococcus aureus
6098:
6084:
5146:
5132:
4924:
3611:"Drug prophylaxis for travelers' diarrhea"
3168:"Trimethoprim, a sulphonamide potentiator"
2691:Centers for Disease Control and Prevention
2679:
2677:
2593:. Elsevier Health Sciences. p. 1173.
2356:
2354:
2352:
2350:
2348:
2346:
2344:
2342:
2340:
2338:
616:) that reduce the body's ability to fight
551:(slowly injected into a vein with an IV).
459:
368:
4993:
4983:
4942:
4893:
4852:
4811:
4632:
4622:
4565:
4481:
4440:
4391:
4350:
4301:
4252:
4203:
4154:
4143:The Journal of Antimicrobial Chemotherapy
4070:
4021:
3929:
3845:
3796:
3747:
3626:
3462:
3191:
2944:
2903:
2568:
2526:
2524:
2522:
1313:(increases plasma levels of both drugs),
1216:Contraindications include the following:
4658:Journal of Pediatric Hematology/Oncology
3497:The Pediatric Infectious Disease Journal
2969:
2767:
2765:
2763:
2761:
2759:
2757:
2755:
2577:
2530:
2214:Co-trimoxazole (used as generic UK name)
2074:
2018:activity against both non-resistant and
1883:
1547:
554:Trimethoprim/sulfamethoxazole is on the
102:TMP/SMX, cotrimoxazole, Co-trimoxazole (
5062:
4714:10.7326/0003-4819-124-9-199605010-00003
4504:
2823:Infectious Disease Epidemiology Section
2674:
2335:
455:
14:
6821:
4325:Vilchèze C, Jacobs WR (October 2012).
2724:
2722:
2720:
2718:
2716:
2714:
2549:
2519:
2405:Therapeutic Goods Administration (TGA)
1695:
1533:treatment in cases of blood dyscrasias
499:medication used to treat a variety of
281:
107:
6829:Acetaldehyde dehydrogenase inhibitors
6079:
5127:
4792:Antimicrobial Agents and Chemotherapy
4415:Fenollar F, Raoult D (January 2001).
4331:Antimicrobial Agents and Chemotherapy
4282:Antimicrobial Agents and Chemotherapy
4233:Antimicrobial Agents and Chemotherapy
4184:Antimicrobial Agents and Chemotherapy
4051:Antimicrobial Agents and Chemotherapy
4002:Antimicrobial Agents and Chemotherapy
3288:from the original on 26 February 2018
3284:. U.S. National Library of Medicine.
3249:
3214:
3069:
2988:from the original on 6 September 2015
2850:
2832:from the original on 23 February 2014
2752:
2563:. Geneva: World Health Organization.
2507:from the original on 29 December 2021
2474:from the original on 29 December 2021
2437:from the original on 29 December 2021
2411:from the original on 29 December 2021
2395:
2393:
2391:
2389:
2387:
2385:
2383:
2368:from the original on 6 September 2015
2323:from the original on 6 September 2015
1344:, half-life of phenytoin is increased
1317:(increased risk of crystalluria) and
1230:Serious haematological disorders and
1151:It appears to be safe for use during
1144:, cardiovascular malformations (e.g.
428:
408:
294:
143:
125:
6854:Drugs developed by Hoffmann-La Roche
5050:from the original on 1 February 2018
4925:Alavi SM, Alavi L (September 2010).
3421:from the original on 18 January 2021
3166:Bushby SR, Hitchings GH (May 1968).
2740:from the original on 16 January 2014
2730:"trimethoprim/sulfamethoxazole (Rx)"
2637:from the original on 15 January 2024
2195:Bactrim, Bactrimel (manufactured by
2151:pneumonia is significantly lacking.
1518:Administration of activated charcoal
1211:
230:
220:
5075:. GlaxoSmithKline. 13 August 2017.
4519:10.1136/postgradmedj-2012-202684rep
3885:from the original on 8 January 2014
3063:
3034:
2711:
2607:from the original on 29 August 2021
1611:Pharmacokinetics of co-trimoxazole
1200:may occasionally occur. Its use in
388:
339:
27:Combination of two antibiotic drugs
24:
3184:10.1111/j.1476-5381.1968.tb00475.x
3041:Joint Formulary Committee (2013).
3022:from the original on 19 April 2019
2380:
1552:Tetrahydrofolate synthesis pathway
1466:Likely signs of toxicity include:
1279:due to the potential for additive
1166:
25:
6870:
5108:from the original on 16 June 2015
2699:from the original on 26 July 2021
643:
257:
175:
6806:
5082:from the original on 1 June 2018
5018:"Co-trimoxazole Medicinal forms"
4567:10.1111/j.1468-1293.2007.00530.x
4380:The European Respiratory Journal
3588:10.1001/jama.1990.03440020091039
3509:10.1097/00006454-200103000-00009
3307:Trubiano JA, Grayson ML (2017).
3045:British National Formulary (BNF)
2946:10.1111/j.1471-0528.2011.03041.x
2786:10.2165/00003495-198224060-00002
2401:"Bactrim DS tablet blister pack"
1763:Acute infective exacerbation of
1745:
1731:
1717:
1208:as long as the baby is healthy.
1155:as long as the baby is healthy.
751:Chryseobacterium meningosepticum
40:
5094:
5010:
4959:
4918:
4869:
4828:
4779:
4736:
4692:
4649:
4590:
4498:
4483:10.4321/s1130-01082010000200006
4457:
4408:
4367:
4318:
4269:
4220:
4171:
4130:
4087:
4038:
3989:
3946:
3897:
3862:
3813:
3764:
3715:
3679:
3643:
3602:
3567:
3531:
3487:
3433:
3374:
3339:
3300:
3270:
3243:
3208:
3159:
3004:
2920:
2879:
2844:
2808:
2649:
2619:
2077:Fungal and protozoal infections
1700:
1543:
1246:
569:
94:Bactrim, Cotrim, Septra, others
6635:piperaquine/dihydroartemisinin
4847:(7): 932–3, author reply 933.
3922:10.1002/14651858.CD006784.pub4
3838:10.1002/14651858.CD004404.pub3
3360:10.1080/1120009X.1993.11741097
3314:Kucers' the Use of Antibiotics
2423:
2178:
1707:Indications for co-trimoxazole
1406:analogue antineoplastics like
270:
13:
1:
6199:trimethoprim/sulfamethoxazole
5489:Trimethoprim/sulfamethoxazole
3789:10.1016/S0140-6736(13)61951-0
3399:10.1016/S0140-6736(04)17225-5
3125:The Annals of Pharmacotherapy
3072:Australian Medicines Handbook
2298:
2141:acute lymphoblastic leukaemia
1848:, treatment & prophylaxis
1778:Clinical trials are lacking.
1593:(DHFR), hence inhibiting the
612:, or take medicines (such as
486:Trimethoprim/sulfamethoxazole
154:Sulfamethoxazole trimethoprim
34:Trimethoprim/sulfamethoxazole
6597:Fixed-dose (co-formulated)
4841:Clinical Infectious Diseases
4670:10.1097/MPH.0b013e3181fd6fca
4624:10.1371/journal.pone.0056916
4507:Postgraduate Medical Journal
3615:Clinical Infectious Diseases
3258:(Suppl): Suppl:18–Suppl:21.
3252:Postgraduate Medical Journal
2865:10.3928/00904481-20130619-13
2290:
1177:Common side effects include
1128:Pregnancy and breast feeding
1007:Stenotrophomonas maltophilia
1000:Staphylococcus saprophyticus
525:respiratory tract infections
488:, sold under the brand name
7:
6849:Drugs developed by Novartis
5494:Ormetoprim/sulfadimethoxine
4702:Annals of Internal Medicine
3967:10.1592/phco.25.2.253.56956
3553:10.7326/0003-4819-106-2-216
3541:Annals of Internal Medicine
2233:Infectrin, Bactrim (Brazil)
1524:General supportive measures
1461:
1120:(the causative organism of
1097:Yersinia pseudotuberculosis
10:
6875:
6844:Drugs developed by GSK plc
4944:10.1016/j.ijid.2009.11.015
3740:10.4269/ajtmh.2012.12-0136
3223:(Suppl): Suppl:1–Suppl21.
2905:10.1016/j.ijid.2011.01.007
2573:. WHO/MHP/HPS/EML/2023.02.
2199:and distributed in Europe)
1830:Paediatric population only
1170:
993:Staphylococcus epidermidis
860:Mycobacterium tuberculosis
503:. It consists of one part
6839:Drugs developed by Pfizer
6757:
6733:
6705:
6679:
6643:
6587:
6532:
6492:
6479:sulfadoxine/pyrimethamine
6471:
6448:
6404:
6395:
6361:
6335:
6282:
6271:
6262:
6253:
6244:
6207:
6189:
6164:
6148:
6137:
6126:
6036:
6014:
5971:
5961:
5924:
5896:
5875:
5818:
5746:
5698:
5632:
5623:
5575:
5547:
5512:
5504:Pyrimethamine/sulfadoxine
5481:
5431:
5368:
5340:
5261:
5246:
5196:
5174:
4937:(Supplement 3): e67–e69.
4895:10.4269/ajtmh.2009.80.583
4433:10.1128/CDLI.8.1.1-8.2001
4393:10.1183/09031936.00114812
4108:10.1179/joc.2009.21.2.115
3012:"Drugs & Medications"
2557:World Health Organization
2270:Septran (GlaxoSmithKline)
1757:
1743:
1729:
1715:
1712:
1158:
731:Burkholderia pseudomallei
628:pneumonia as a result of
471:
439:
419:
399:
379:
359:
334:
314:
309:
247:
242:
207:
189:
163:
133:
115:
98:
88:
83:
68:
56:
51:
39:
3701:10.4269/ajtmh.2001.64.24
3137:10.1177/1060028013509973
2685:"Pneumocystis pneumonia"
1021:Streptococcus pneumoniae
1014:Streptococcus agalactiae
904:Plesiomonas shigelloides
547:(swallowed by mouth) or
519:(MRSA) skin infections,
513:urinary tract infections
6834:Combination antibiotics
6630:artesunate/pyronaridine
6607:artemether/lumefantrine
4985:10.4103/0253-7184.81255
4096:Journal of Chemotherapy
3348:Journal of Chemotherapy
1866:Urinary tract infection
1591:dihydrofolate reductase
1430:while on co-trimoxazole
1078:Yersinia enterocolitica
812:Klebsiella granulomatis
566:million prescriptions.
558:. It is available as a
75:Dihydrofolate reductase
6618:artesunate/amodiaquine
5403:Sulfamethoxypyridazine
3455:10.1542/peds.2006-2787
3278:"Tetrahydrofolic acid"
2124:Pneumocystis jirovecii
2020:methicillin-resistant
1755:-labelled indication?
1741:-labelled indication?
1727:-labelled indication?
1553:
1497:Bone marrow depression
1239:chronic kidney disease
1117:Francisella tularensis
1107:Pseudomonas aeruginosa
1035:Streptococcus viridans
1028:Streptococcus pyogenes
911:Pneumocystis jirovecii
884:Neisseria meningitidis
834:Listeria monocytogenes
630:antiretroviral therapy
596:Pneumocystis jirovecii
587:Pneumocystis jirovecii
533:pneumocystis pneumonia
511:. It is used to treat
494:fixed-dose combination
63:Sulfonamide antibiotic
6652:artesunate/mefloquine
6624:artesunate/mefloquine
5876:Newer non-fluorinated
5513:Other DHPS inhibitors
5499:Pyrimethamine/dapsone
5326:Succinylsulfathiazole
5322:Phthalylsulfathiazole
5206:2,4-Diaminopyrimidine
4804:10.1128/AAC.42.6.1346
3875:Infection Medication"
3323:10.1201/9781498747967
3070:Rossi S, ed. (2013).
2627:"The Top 300 of 2021"
2185:British Approved Name
2022:Staphylococcus aureus
1996:Staphylococcus aureus
1787:-infected individuals
1551:
1372:, more specifically,
1196:Clostridium difficile
986:Staphylococcus aureus
889:meningococcal disease
872:Neisseria gonorrhoeae
846:Moraxella catarrhalis
819:Klebsiella pneumoniae
600:(PCP) People who get
6664:quinine/tetracycline
6336:4-Methanolquinolines
6111:antiprotozoal agents
5300:Acetyl sulfisoxazole
5159:inhibit nucleic acid
4343:10.1128/AAC.00832-12
4294:10.1128/AAC.01658-08
4245:10.1128/AAC.01046-12
4196:10.1128/AAC.00706-11
4063:10.1128/AAC.01046-07
4014:10.1128/AAC.00206-07
3215:Böhni E (1969). "".
3097:Connecticut Medicine
2247:and other countries)
1886:Bacterial infections
1846:Travellers' diarrhea
1569:Sulfamethoxazole, a
1364:bone marrow toxicity
1324:Anticoagulants like
1309:Antibacterials like
1054:Tropheryma whippelii
939:Providencia stuartii
932:Providencia rettgeri
712:Burkholderia cepacia
692:Bordetella pertussis
549:intravenous infusion
501:bacterial infections
6661:quinine/doxycycline
6658:quinine/clindamycin
6646:(not co-formulated)
5675:Alalevonadifloxacin
5342:Intermediate-acting
4615:2013PLoSO...856916M
4417:"Whipple's disease"
3393:(9443): 1428–1434.
2695:. 13 October 2021.
2531:Hamilton R (2015).
2222:AFT Pharmaceuticals
2202:Bactrom (Venezuela)
2025:(MRSA) infections.
1758:Literature support
1709:
1696:Society and culture
1612:
1536:Forcing oral fluids
1291:methaemoglobinaemia
1289:— additive risk of
1138:neural tube defects
853:Morganella morganii
719:Burkholderia mallei
685:Bartonella henselae
521:travelers' diarrhea
492:among others, is a
290:(Prescription only)
266:(Prescription only)
36:
6784:Never to phase III
6644:Other combinations
6524:dihydroartemisinin
6306:hydroxychloroquine
6063:Never to phase III
5564:thereby inhibiting
5552:(inhibit bacterial
5398:Sulfametoxydiazine
5186:thereby inhibiting
5179:(inhibit bacterial
4757:10.1007/BF01967063
4156:10.1093/jac/dkq179
3879:Medscape Reference
2734:Medscape Reference
1819:in HIV infection.
1705:
1610:
1584:-aminobenzoic acid
1554:
1338:— effects enhanced
1191:allergic reactions
560:generic medication
32:
6794:
6793:
6729:
6728:
6701:
6700:
6697:
6696:
6675:
6674:
6671:
6670:
6583:
6582:
6488:
6487:
6391:
6390:
6240:
6239:
6166:Cryptosporidiosis
6073:
6072:
6032:
6031:
5957:
5956:
5920:
5919:
5871:
5870:
5543:
5542:
5477:
5476:
5182:purine metabolism
4513:(1057): 659–665.
4337:(10): 5142–5148.
4288:(11): 4789–4793.
4239:(11): 5990–5993.
4190:(12): 5430–5432.
3783:(9919): 807–814.
3665:10.1159/000250840
3229:10.1159/000220651
3081:978-0-9805790-9-3
3056:978-0-85711-084-8
2939:(11): 1374–1382.
2600:978-0-7295-8708-2
2470:. 1 August 2021.
2227:Diseptyl (Israel)
2176:
2175:
2166:
2057:Whipple's disease
1831:
1799:Effective in one
1693:
1692:
1604:the first place.
1483:Mental depression
1428:thrombocytopaenia
1212:Contraindications
1146:Ebstein's anomaly
1059:Whipple's disease
1042:Toxoplasma gondii
918:Proteus mirabilis
483:
482:
441:CompTox Dashboard
298:
285:
273:
261:
179:
146:
110:
16:(Redirected from
6866:
6811:
6810:
6809:
6802:
6594:
6593:
6402:
6401:
6280:
6279:
6269:
6268:
6260:
6259:
6251:
6250:
6162:
6161:
6146:
6145:
6135:
6134:
6117:antiparasitics (
6100:
6093:
6086:
6077:
6076:
5969:
5968:
5936:
5935:
5671:Levonadifloxacin
5630:
5629:
5625:Fluoroquinolones
5573:
5572:
5378:Sulfadimethoxine
5350:Sulfamethoxazole
5271:Sulfaisodimidine
5259:
5258:
5194:
5193:
5148:
5141:
5134:
5125:
5124:
5118:
5117:
5115:
5113:
5098:
5092:
5091:
5089:
5087:
5081:
5074:
5066:
5060:
5059:
5057:
5055:
5036:
5030:
5029:
5027:
5025:
5014:
5008:
5007:
4997:
4987:
4963:
4957:
4956:
4946:
4922:
4916:
4915:
4897:
4873:
4867:
4866:
4856:
4832:
4826:
4825:
4815:
4798:(6): 1346–1349.
4783:
4777:
4776:
4740:
4734:
4733:
4696:
4690:
4689:
4653:
4647:
4646:
4636:
4626:
4594:
4588:
4587:
4569:
4545:
4539:
4538:
4502:
4496:
4495:
4485:
4461:
4455:
4454:
4444:
4412:
4406:
4405:
4395:
4371:
4365:
4364:
4354:
4322:
4316:
4315:
4305:
4273:
4267:
4266:
4256:
4224:
4218:
4217:
4207:
4175:
4169:
4168:
4158:
4149:(8): 1779–1783.
4134:
4128:
4127:
4091:
4085:
4084:
4074:
4057:(6): 2156–2162.
4042:
4036:
4035:
4025:
4008:(7): 2628–2630.
3993:
3987:
3986:
3950:
3944:
3943:
3933:
3901:
3895:
3894:
3892:
3890:
3866:
3860:
3859:
3849:
3817:
3811:
3810:
3800:
3768:
3762:
3761:
3751:
3719:
3713:
3712:
3683:
3677:
3676:
3647:
3641:
3640:
3630:
3606:
3600:
3599:
3571:
3565:
3564:
3535:
3529:
3528:
3491:
3485:
3484:
3466:
3437:
3431:
3430:
3428:
3426:
3378:
3372:
3371:
3343:
3337:
3336:
3304:
3298:
3297:
3295:
3293:
3274:
3268:
3267:
3247:
3241:
3240:
3212:
3206:
3205:
3195:
3163:
3157:
3156:
3119:
3113:
3112:
3092:
3086:
3085:
3067:
3061:
3060:
3048:
3038:
3032:
3031:
3029:
3027:
3008:
3002:
3001:
2995:
2993:
2978:
2967:
2966:
2948:
2924:
2918:
2917:
2907:
2898:(5): e336–e341.
2883:
2877:
2876:
2853:Pediatric Annals
2848:
2842:
2841:
2839:
2837:
2831:
2820:
2812:
2806:
2805:
2769:
2750:
2749:
2747:
2745:
2726:
2709:
2708:
2706:
2704:
2681:
2672:
2671:
2669:
2667:
2653:
2647:
2646:
2644:
2642:
2623:
2617:
2616:
2614:
2612:
2584:
2575:
2574:
2572:
2553:
2547:
2546:
2528:
2517:
2516:
2514:
2512:
2493:
2484:
2483:
2481:
2479:
2460:
2447:
2446:
2444:
2442:
2427:
2421:
2420:
2418:
2416:
2397:
2378:
2377:
2375:
2373:
2362:"Co-trimoxazole"
2358:
2333:
2332:
2330:
2328:
2319:. 8 March 2019.
2309:
2267:Septram (Panama)
2258:Aspen Pharmacare
2164:
1957:(whooping cough)
1829:
1750:
1749:
1736:
1735:
1722:
1721:
1710:
1704:
1651:Sulfamethoxazole
1613:
1609:
1563:folate synthesis
1531:Calcium folinate
1500:Loss of appetite
1489:Thrombocytopenia
1447:Sulfamethoxazole
946:Salmonella typhi
925:Proteus vulgaris
782:Escherichia coli
632:(ART). However,
622:viral infections
565:
509:sulfamethoxazole
479:
478:
464:
463:
449:
447:
432:
412:
392:
372:
352:
342:
341:
327:
296:
293:
283:
280:
272:
269:
259:
256:
234:
224:
177:
174:
156:
145:
142:
129:
109:
106:
58:Sulfamethoxazole
44:
37:
35:
31:
21:
6874:
6873:
6869:
6868:
6867:
6865:
6864:
6863:
6819:
6818:
6817:
6807:
6805:
6797:
6795:
6790:
6789:
6774:Clinical trials
6753:
6736:
6725:
6708:
6693:
6667:
6645:
6639:
6589:
6579:
6528:
6495:
6484:
6467:
6444:
6406:DHFR inhibitors
6387:
6357:
6331:
6284:Aminoquinolines
6274:
6264:
6236:
6203:
6185:
6153:
6140:
6129:
6122:
6104:
6074:
6069:
6068:
6053:Clinical trials
6028:
6010:
5976:
5953:
5929:
5916:
5892:
5867:
5814:
5742:
5694:
5619:
5567:DNA replication
5565:
5563:
5557:
5553:
5551:
5539:
5508:
5473:
5432:Other/ungrouped
5427:
5393:Sulfametomidine
5364:
5336:
5250:
5242:
5189:
5187:
5185:
5180:
5178:
5170:
5152:
5122:
5121:
5111:
5109:
5100:
5099:
5095:
5085:
5083:
5079:
5072:
5068:
5067:
5063:
5053:
5051:
5038:
5037:
5033:
5023:
5021:
5016:
5015:
5011:
4964:
4960:
4923:
4919:
4874:
4870:
4833:
4829:
4784:
4780:
4741:
4737:
4697:
4693:
4654:
4650:
4595:
4591:
4546:
4542:
4503:
4499:
4462:
4458:
4413:
4409:
4372:
4368:
4323:
4319:
4274:
4270:
4225:
4221:
4176:
4172:
4135:
4131:
4092:
4088:
4043:
4039:
3994:
3990:
3955:Pharmacotherapy
3951:
3947:
3916:(8): CD006784.
3902:
3898:
3888:
3886:
3867:
3863:
3832:(3): CD004404.
3818:
3814:
3769:
3765:
3720:
3716:
3684:
3680:
3648:
3644:
3607:
3603:
3572:
3568:
3536:
3532:
3492:
3488:
3438:
3434:
3424:
3422:
3379:
3375:
3344:
3340:
3333:
3305:
3301:
3291:
3289:
3276:
3275:
3271:
3248:
3244:
3213:
3209:
3164:
3160:
3131:(12): 1618–26.
3120:
3116:
3093:
3089:
3082:
3068:
3064:
3057:
3039:
3035:
3025:
3023:
3010:
3009:
3005:
2991:
2989:
2980:
2979:
2970:
2925:
2921:
2884:
2880:
2849:
2845:
2835:
2833:
2829:
2818:
2814:
2813:
2809:
2770:
2753:
2743:
2741:
2728:
2727:
2712:
2702:
2700:
2683:
2682:
2675:
2665:
2663:
2655:
2654:
2650:
2640:
2638:
2625:
2624:
2620:
2610:
2608:
2601:
2585:
2578:
2554:
2550:
2543:
2529:
2520:
2510:
2508:
2495:
2494:
2487:
2477:
2475:
2462:
2461:
2450:
2440:
2438:
2429:
2428:
2424:
2414:
2412:
2399:
2398:
2381:
2371:
2369:
2360:
2359:
2336:
2326:
2324:
2311:
2310:
2306:
2301:
2293:
2288:
2273:Septrin (Spain)
2262:GlaxoSmithKline
2181:
2165:Prevention only
2078:
1887:
1783:Prophylaxis in
1751:
1744:
1737:
1730:
1723:
1716:
1708:
1703:
1698:
1641:
1635:Protein binding
1630:
1622:
1546:
1521:Stomach pumping
1512:
1509:Unconsciousness
1464:
1459:
1296:Antiarrhythmics
1249:
1244:
1214:
1175:
1169:
1167:Adverse effects
1161:
1130:
1102:
1085:Yersinia pestis
1066:Vibrio cholerae
646:
591:
572:
563:
539:in people with
474:
472:
467:
443:
435:
415:
395:
375:
355:
338:
330:
305:
238:
192:
185:
166:
159:
47:
28:
23:
22:
15:
12:
11:
5:
6872:
6862:
6861:
6856:
6851:
6846:
6841:
6836:
6831:
6816:
6815:
6792:
6791:
6788:
6787:
6786:
6785:
6782:
6771:
6765:
6759:
6758:
6755:
6754:
6752:
6751:
6745:Blastocystosis
6741:
6739:
6731:
6730:
6727:
6726:
6724:
6723:
6713:
6711:
6703:
6702:
6699:
6698:
6695:
6694:
6692:
6691:
6685:
6683:
6677:
6676:
6673:
6672:
6669:
6668:
6666:
6665:
6662:
6659:
6656:
6653:
6649:
6647:
6641:
6640:
6638:
6637:
6632:
6627:
6621:
6615:
6609:
6603:
6601:
6591:
6585:
6584:
6581:
6580:
6578:
6577:
6572:
6567:
6562:
6557:
6552:
6547:
6536:
6534:
6530:
6529:
6527:
6526:
6521:
6516:
6511:
6506:
6500:
6498:
6490:
6489:
6486:
6485:
6483:
6482:
6475:
6473:
6472:Co-formulation
6469:
6468:
6466:
6465:
6460:
6454:
6452:
6446:
6445:
6443:
6442:
6441:
6440:
6435:
6433:chlorproguanil
6422:
6421:
6416:
6410:
6408:
6399:
6393:
6392:
6389:
6388:
6386:
6385:
6379:
6378:
6377:
6376:
6365:
6363:
6359:
6358:
6356:
6355:
6350:
6345:
6339:
6337:
6333:
6332:
6330:
6329:
6324:
6319:
6309:
6308:
6303:
6298:
6288:
6286:
6277:
6266:
6257:
6248:
6242:
6241:
6238:
6237:
6235:
6234:
6229:
6224:
6219:
6213:
6211:
6205:
6204:
6202:
6201:
6195:
6193:
6187:
6186:
6184:
6183:
6170:
6168:
6159:
6143:
6132:
6124:
6123:
6115:Chromalveolata
6107:Antiparasitics
6103:
6102:
6095:
6088:
6080:
6071:
6070:
6067:
6066:
6065:
6064:
6061:
6050:
6044:
6038:
6037:
6034:
6033:
6030:
6029:
6027:
6026:
6020:
6018:
6012:
6011:
6009:
6008:
6003:
5998:
5993:
5988:
5982:
5980:
5978:RNA polymerase
5966:
5959:
5958:
5955:
5954:
5952:
5951:
5945:
5943:
5940:Nitroimidazole
5933:
5922:
5921:
5918:
5917:
5915:
5914:
5908:Aminocoumarins
5904:
5902:
5894:
5893:
5891:
5890:
5885:
5879:
5877:
5873:
5872:
5869:
5868:
5866:
5865:
5860:
5855:
5850:
5845:
5840:
5835:
5830:
5824:
5822:
5816:
5815:
5813:
5812:
5810:Alatrofloxacin
5803:
5798:
5793:
5788:
5783:
5778:
5773:
5768:
5763:
5758:
5752:
5750:
5748:4th generation
5744:
5743:
5741:
5740:
5735:
5730:
5725:
5720:
5715:
5710:
5704:
5702:
5700:3rd generation
5696:
5695:
5693:
5692:
5687:
5682:
5677:
5664:
5659:
5654:
5649:
5644:
5638:
5636:
5634:2nd generation
5627:
5621:
5620:
5618:
5617:
5612:
5610:Piromidic acid
5607:
5605:Pipemidic acid
5602:
5597:
5595:Nalidixic acid
5592:
5587:
5581:
5579:
5577:1st generation
5570:
5545:
5544:
5541:
5540:
5538:
5537:
5532:
5527:
5522:
5516:
5514:
5510:
5509:
5507:
5506:
5501:
5496:
5491:
5485:
5483:
5479:
5478:
5475:
5474:
5472:
5471:
5466:
5461:
5459:Sulfaguanidine
5456:
5454:Sulfadicramide
5451:
5446:
5441:
5435:
5433:
5429:
5428:
5426:
5425:
5420:
5418:Sulfaphenazole
5415:
5410:
5405:
5400:
5395:
5390:
5385:
5380:
5374:
5372:
5366:
5365:
5363:
5362:
5357:
5352:
5346:
5344:
5338:
5337:
5335:
5334:
5329:
5315:
5314:
5313:
5303:
5293:
5283:
5278:
5276:Sulfamethizole
5273:
5267:
5265:
5256:
5253:DHPS inhibitor
5244:
5243:
5241:
5240:
5239:
5238:
5233:
5228:
5223:
5218:
5213:
5202:
5200:
5198:DHFR inhibitor
5191:
5172:
5171:
5155:Antibacterials
5151:
5150:
5143:
5136:
5128:
5120:
5119:
5093:
5061:
5031:
5009:
4958:
4917:
4888:(4): 583–587.
4868:
4854:10.1086/368209
4827:
4778:
4751:(2): 125–130.
4735:
4708:(9): 792–802.
4691:
4648:
4589:
4560:(2): 126–130.
4540:
4497:
4476:(2): 108–123.
4456:
4407:
4386:(2): 504–512.
4366:
4317:
4268:
4219:
4170:
4129:
4102:(2): 115–126.
4086:
4037:
3988:
3961:(2): 253–264.
3945:
3896:
3861:
3812:
3763:
3734:(5): 927–932.
3714:
3695:(1–2): 24–27.
3678:
3659:(4): 245–253.
3642:
3628:10.1086/338640
3621:(5): 628–633.
3601:
3582:(2): 257–261.
3566:
3547:(2): 216–220.
3530:
3503:(3): 260–264.
3486:
3449:(5): 897–904.
3432:
3373:
3354:(6): 465–469.
3338:
3331:
3299:
3269:
3242:
3207:
3158:
3114:
3087:
3080:
3062:
3055:
3033:
3003:
2968:
2919:
2878:
2859:(7): 288–292.
2843:
2807:
2780:(6): 459–518.
2751:
2710:
2673:
2648:
2618:
2599:
2576:
2548:
2541:
2518:
2485:
2448:
2422:
2379:
2334:
2303:
2302:
2300:
2297:
2292:
2289:
2287:
2286:
2283:
2280:
2277:
2274:
2271:
2268:
2265:
2254:
2251:
2248:
2237:
2234:
2231:
2228:
2225:
2218:
2215:
2212:
2209:
2206:
2203:
2200:
2192:
2180:
2177:
2174:
2173:
2170:
2167:
2162:
2159:
2153:
2152:
2137:
2134:
2131:
2128:
2119:
2118:
2115:
2112:
2109:
2106:
2100:
2099:
2096:
2093:
2090:
2087:
2081:
2080:
2076:
2072:
2071:
2068:
2065:
2062:
2059:
2053:
2052:
2042:
2039:
2036:
2033:
2027:
2026:
2009:
2006:
2003:
2000:
1991:
1990:
1986:
1983:
1980:
1977:
1971:
1970:
1967:
1964:
1961:
1958:
1951:
1950:
1943:
1940:
1937:
1934:
1928:
1927:
1924:
1921:
1918:
1915:
1909:
1908:
1905:
1902:
1899:
1896:
1890:
1889:
1885:
1881:
1880:
1877:
1874:
1871:
1868:
1862:
1861:
1858:
1855:
1852:
1849:
1842:
1841:
1838:
1835:
1832:
1827:
1821:
1820:
1797:
1794:
1791:
1788:
1780:
1779:
1776:
1773:
1770:
1767:
1760:
1759:
1756:
1742:
1728:
1714:
1706:
1702:
1699:
1697:
1694:
1691:
1690:
1687:
1684:
1681:
1678:
1675:
1669:
1668:
1665:
1662:
1659:
1656:
1653:
1647:
1646:
1643:
1639:
1636:
1633:
1628:
1624:
1620:
1617:
1545:
1542:
1538:
1537:
1534:
1528:
1525:
1522:
1519:
1511:
1510:
1507:
1504:
1501:
1498:
1495:
1490:
1487:
1484:
1481:
1478:
1475:
1472:
1468:
1463:
1460:
1458:
1457:
1450:
1443:
1440:Spironolactone
1437:
1431:
1421:
1415:
1412:mercaptopurine
1401:
1395:
1385:
1367:
1345:
1339:
1333:
1322:
1307:
1293:
1284:
1257:ACE inhibitors
1253:
1248:
1245:
1243:
1242:
1235:
1228:
1225:
1222:
1218:
1213:
1210:
1168:
1165:
1160:
1157:
1129:
1126:
1101:
1100:
1093:
1090:bubonic plague
1081:
1074:
1062:
1050:
1038:
1031:
1024:
1017:
1010:
1003:
996:
989:
982:
974:
966:
958:food poisoning
954:
942:
935:
928:
921:
914:
907:
900:
892:
880:
868:
856:
849:
842:
830:
822:
815:
808:
800:
793:
785:
778:
770:
762:
754:
747:
739:
727:
715:
708:
700:
688:
681:
667:
659:
650:
645:
644:Susceptibility
642:
590:
584:
571:
568:
507:to five parts
481:
480:
469:
468:
466:
465:
452:
450:
437:
436:
434:
433:
425:
423:
417:
416:
414:
413:
405:
403:
397:
396:
394:
393:
385:
383:
377:
376:
374:
373:
365:
363:
357:
356:
354:
353:
345:
343:
332:
331:
329:
328:
320:
318:
312:
311:
307:
306:
304:
303:
291:
278:
267:
253:
251:
245:
244:
240:
239:
237:
236:
213:
211:
205:
204:
195:
193:administration
187:
186:
184:
183:
181:
171:
169:
161:
160:
158:
157:
139:
137:
131:
130:
123:
113:
112:
100:
96:
95:
92:
86:
85:
81:
80:
72:
66:
65:
60:
54:
53:
52:Combination of
49:
48:
45:
26:
9:
6:
4:
3:
2:
6871:
6860:
6857:
6855:
6852:
6850:
6847:
6845:
6842:
6840:
6837:
6835:
6832:
6830:
6827:
6826:
6824:
6814:
6804:
6803:
6800:
6783:
6781:
6778:
6777:
6775:
6772:
6769:
6766:
6764:
6761:
6760:
6756:
6750:
6749:metronidazole
6746:
6743:
6742:
6740:
6738:
6732:
6722:
6718:
6717:Balantidiasis
6715:
6714:
6712:
6710:
6704:
6690:
6687:
6686:
6684:
6682:
6678:
6663:
6660:
6657:
6655:artesunate/SP
6654:
6651:
6650:
6648:
6642:
6636:
6633:
6631:
6628:
6625:
6622:
6619:
6616:
6613:
6610:
6608:
6605:
6604:
6602:
6600:
6595:
6592:
6586:
6576:
6573:
6571:
6568:
6566:
6563:
6561:
6558:
6556:
6553:
6551:
6548:
6545:
6541:
6538:
6537:
6535:
6531:
6525:
6522:
6520:
6517:
6515:
6512:
6510:
6507:
6505:
6502:
6501:
6499:
6497:
6494:Sesquiterpene
6491:
6480:
6477:
6476:
6474:
6470:
6464:
6461:
6459:
6456:
6455:
6453:
6451:
6447:
6439:
6436:
6434:
6431:
6430:
6429:
6428:
6424:
6423:
6420:
6417:
6415:
6414:pyrimethamine
6412:
6411:
6409:
6407:
6403:
6400:
6398:
6394:
6384:
6381:
6380:
6375:
6372:
6371:
6370:
6367:
6366:
6364:
6360:
6354:
6351:
6349:
6346:
6344:
6341:
6340:
6338:
6334:
6328:
6325:
6323:
6320:
6318:
6314:
6311:
6310:
6307:
6304:
6302:
6299:
6297:
6293:
6290:
6289:
6287:
6285:
6281:
6278:
6276:
6270:
6267:
6261:
6258:
6256:
6252:
6249:
6247:
6243:
6233:
6230:
6228:
6225:
6223:
6220:
6218:
6217:pyrimethamine
6215:
6214:
6212:
6210:
6209:Toxoplasmosis
6206:
6200:
6197:
6196:
6194:
6192:
6188:
6181:
6177:
6176:
6172:
6171:
6169:
6167:
6163:
6160:
6157:
6156:Coccidiostats
6151:
6147:
6144:
6142:
6136:
6133:
6131:
6125:
6120:
6116:
6112:
6108:
6101:
6096:
6094:
6089:
6087:
6082:
6081:
6078:
6062:
6060:
6057:
6056:
6054:
6051:
6048:
6045:
6043:
6040:
6039:
6035:
6025:
6022:
6021:
6019:
6017:
6013:
6007:
6004:
6002:
5999:
5997:
5994:
5992:
5989:
5987:
5984:
5983:
5981:
5979:
5974:
5970:
5967:
5964:
5960:
5950:
5947:
5946:
5944:
5941:
5937:
5934:
5932:
5927:
5923:
5913:
5909:
5906:
5905:
5903:
5900:
5895:
5889:
5886:
5884:
5881:
5880:
5878:
5874:
5864:
5861:
5859:
5858:Pradofloxacin
5856:
5854:
5851:
5849:
5848:Marbofloxacin
5846:
5844:
5841:
5839:
5836:
5834:
5831:
5829:
5826:
5825:
5823:
5821:
5817:
5811:
5807:
5806:Trovafloxacin
5804:
5802:
5799:
5797:
5796:Prulifloxacin
5794:
5792:
5789:
5787:
5786:Clinafloxacin
5784:
5782:
5779:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5759:
5757:
5754:
5753:
5751:
5749:
5745:
5739:
5736:
5734:
5731:
5729:
5726:
5724:
5721:
5719:
5718:Grepafloxacin
5716:
5714:
5711:
5709:
5706:
5705:
5703:
5701:
5697:
5691:
5688:
5686:
5683:
5681:
5678:
5676:
5672:
5668:
5665:
5663:
5660:
5658:
5655:
5653:
5650:
5648:
5645:
5643:
5642:Ciprofloxacin
5640:
5639:
5637:
5635:
5631:
5628:
5626:
5622:
5616:
5613:
5611:
5608:
5606:
5603:
5601:
5600:Oxolinic acid
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5582:
5580:
5578:
5574:
5571:
5568:
5561:
5556:
5555:topoisomerase
5550:
5546:
5536:
5533:
5531:
5528:
5526:
5523:
5521:
5520:Acediasulfone
5518:
5517:
5515:
5511:
5505:
5502:
5500:
5497:
5495:
5492:
5490:
5487:
5486:
5484:
5480:
5470:
5467:
5465:
5462:
5460:
5457:
5455:
5452:
5450:
5447:
5445:
5444:Sulfacetamide
5442:
5440:
5437:
5436:
5434:
5430:
5424:
5421:
5419:
5416:
5414:
5413:Sulfamerazine
5411:
5409:
5406:
5404:
5401:
5399:
5396:
5394:
5391:
5389:
5386:
5384:
5381:
5379:
5376:
5375:
5373:
5371:
5367:
5361:
5358:
5356:
5353:
5351:
5348:
5347:
5345:
5343:
5339:
5333:
5332:Sulfathiourea
5330:
5327:
5323:
5319:
5318:Sulfathiazole
5316:
5312:
5309:
5308:
5307:
5306:Sulfanilamide
5304:
5301:
5297:
5296:Sulfafurazole
5294:
5291:
5290:Sulfasalazine
5287:
5286:Sulfapyridine
5284:
5282:
5281:Sulfadimidine
5279:
5277:
5274:
5272:
5269:
5268:
5266:
5264:
5260:
5257:
5254:
5249:
5245:
5237:
5234:
5232:
5229:
5227:
5226:Pyrimethamine
5224:
5222:
5219:
5217:
5214:
5212:
5209:
5208:
5207:
5204:
5203:
5201:
5199:
5195:
5192:
5183:
5177:
5173:
5168:
5164:
5160:
5156:
5149:
5144:
5142:
5137:
5135:
5130:
5129:
5126:
5107:
5103:
5097:
5078:
5071:
5065:
5049:
5045:
5041:
5035:
5019:
5013:
5005:
5001:
4996:
4991:
4986:
4981:
4977:
4973:
4969:
4962:
4954:
4950:
4945:
4940:
4936:
4932:
4928:
4921:
4913:
4909:
4905:
4901:
4896:
4891:
4887:
4883:
4879:
4872:
4864:
4860:
4855:
4850:
4846:
4842:
4838:
4831:
4823:
4819:
4814:
4809:
4805:
4801:
4797:
4793:
4789:
4782:
4774:
4770:
4766:
4762:
4758:
4754:
4750:
4746:
4739:
4731:
4727:
4723:
4719:
4715:
4711:
4707:
4703:
4695:
4687:
4683:
4679:
4675:
4671:
4667:
4663:
4659:
4652:
4644:
4640:
4635:
4630:
4625:
4620:
4616:
4612:
4609:(2): e56916.
4608:
4604:
4600:
4593:
4585:
4581:
4577:
4573:
4568:
4563:
4559:
4555:
4551:
4544:
4536:
4532:
4528:
4524:
4520:
4516:
4512:
4508:
4501:
4493:
4489:
4484:
4479:
4475:
4471:
4467:
4460:
4452:
4448:
4443:
4438:
4434:
4430:
4426:
4422:
4418:
4411:
4403:
4399:
4394:
4389:
4385:
4381:
4377:
4370:
4362:
4358:
4353:
4348:
4344:
4340:
4336:
4332:
4328:
4321:
4313:
4309:
4304:
4299:
4295:
4291:
4287:
4283:
4279:
4272:
4264:
4260:
4255:
4250:
4246:
4242:
4238:
4234:
4230:
4223:
4215:
4211:
4206:
4201:
4197:
4193:
4189:
4185:
4181:
4174:
4166:
4162:
4157:
4152:
4148:
4144:
4140:
4133:
4125:
4121:
4117:
4113:
4109:
4105:
4101:
4097:
4090:
4082:
4078:
4073:
4068:
4064:
4060:
4056:
4052:
4048:
4041:
4033:
4029:
4024:
4019:
4015:
4011:
4007:
4003:
3999:
3992:
3984:
3980:
3976:
3972:
3968:
3964:
3960:
3956:
3949:
3941:
3937:
3932:
3927:
3923:
3919:
3915:
3911:
3907:
3900:
3884:
3880:
3876:
3874:
3865:
3857:
3853:
3848:
3843:
3839:
3835:
3831:
3827:
3823:
3816:
3808:
3804:
3799:
3794:
3790:
3786:
3782:
3778:
3774:
3767:
3759:
3755:
3750:
3745:
3741:
3737:
3733:
3729:
3725:
3718:
3710:
3706:
3702:
3698:
3694:
3690:
3682:
3674:
3670:
3666:
3662:
3658:
3654:
3653:Dermatologica
3646:
3638:
3634:
3629:
3624:
3620:
3616:
3612:
3605:
3597:
3593:
3589:
3585:
3581:
3577:
3570:
3562:
3558:
3554:
3550:
3546:
3542:
3534:
3526:
3522:
3518:
3514:
3510:
3506:
3502:
3498:
3490:
3482:
3478:
3474:
3470:
3465:
3460:
3456:
3452:
3448:
3444:
3436:
3420:
3416:
3412:
3408:
3404:
3400:
3396:
3392:
3388:
3384:
3377:
3369:
3365:
3361:
3357:
3353:
3349:
3342:
3334:
3332:9781498747967
3328:
3324:
3320:
3316:
3315:
3310:
3303:
3287:
3283:
3279:
3273:
3265:
3261:
3257:
3253:
3246:
3238:
3234:
3230:
3226:
3222:
3218:
3211:
3203:
3199:
3194:
3189:
3185:
3181:
3177:
3173:
3169:
3162:
3154:
3150:
3146:
3142:
3138:
3134:
3130:
3126:
3118:
3110:
3106:
3102:
3098:
3091:
3083:
3077:
3073:
3066:
3058:
3052:
3047:
3046:
3037:
3021:
3017:
3013:
3007:
3000:
2987:
2983:
2977:
2975:
2973:
2964:
2960:
2956:
2952:
2947:
2942:
2938:
2934:
2930:
2923:
2915:
2911:
2906:
2901:
2897:
2893:
2889:
2882:
2874:
2870:
2866:
2862:
2858:
2854:
2847:
2828:
2824:
2817:
2811:
2803:
2799:
2795:
2791:
2787:
2783:
2779:
2775:
2768:
2766:
2764:
2762:
2760:
2758:
2756:
2739:
2735:
2731:
2725:
2723:
2721:
2719:
2717:
2715:
2698:
2694:
2692:
2686:
2680:
2678:
2662:
2658:
2652:
2636:
2632:
2628:
2622:
2606:
2602:
2596:
2592:
2591:
2583:
2581:
2571:
2566:
2562:
2558:
2552:
2544:
2542:9781284057560
2538:
2534:
2527:
2525:
2523:
2506:
2502:
2498:
2492:
2490:
2473:
2469:
2465:
2459:
2457:
2455:
2453:
2436:
2432:
2426:
2410:
2406:
2402:
2396:
2394:
2392:
2390:
2388:
2386:
2384:
2367:
2363:
2357:
2355:
2353:
2351:
2349:
2347:
2345:
2343:
2341:
2339:
2322:
2318:
2314:
2308:
2304:
2296:
2284:
2281:
2278:
2275:
2272:
2269:
2266:
2263:
2260:and formerly
2259:
2255:
2252:
2249:
2246:
2242:
2238:
2235:
2232:
2229:
2226:
2223:
2219:
2216:
2213:
2210:
2207:
2204:
2201:
2198:
2194:
2193:
2191:
2188:
2186:
2171:
2168:
2163:
2160:
2158:
2157:Toxoplasmosis
2155:
2154:
2150:
2146:
2142:
2138:
2135:
2132:
2129:
2127:
2125:
2121:
2120:
2116:
2113:
2110:
2107:
2105:
2102:
2101:
2097:
2094:
2091:
2088:
2086:
2083:
2082:
2079:
2073:
2069:
2066:
2063:
2060:
2058:
2055:
2054:
2050:
2046:
2043:
2040:
2037:
2034:
2032:
2029:
2028:
2024:
2023:
2017:
2013:
2010:
2007:
2004:
2001:
1998:
1997:
1993:
1992:
1987:
1984:
1981:
1978:
1976:
1973:
1972:
1968:
1965:
1962:
1959:
1956:
1953:
1952:
1948:
1944:
1941:
1938:
1935:
1933:
1930:
1929:
1925:
1922:
1919:
1916:
1914:
1911:
1910:
1906:
1903:
1900:
1897:
1895:
1894:Acne vulgaris
1892:
1891:
1888:
1882:
1878:
1875:
1872:
1869:
1867:
1864:
1863:
1859:
1856:
1853:
1850:
1847:
1844:
1843:
1839:
1836:
1833:
1828:
1826:
1823:
1822:
1818:
1814:
1810:
1806:
1802:
1798:
1795:
1792:
1789:
1786:
1782:
1781:
1777:
1774:
1771:
1768:
1766:
1762:
1761:
1754:
1748:
1740:
1734:
1726:
1720:
1711:
1688:
1685:
1682:
1679:
1676:
1674:
1671:
1670:
1666:
1663:
1660:
1657:
1654:
1652:
1649:
1648:
1644:
1637:
1634:
1631:
1625:
1618:
1615:
1614:
1608:
1605:
1601:
1598:
1596:
1592:
1587:
1585:
1583:
1578:
1577:
1572:
1567:
1564:
1559:
1550:
1541:
1535:
1532:
1529:
1526:
1523:
1520:
1517:
1516:
1515:
1508:
1505:
1502:
1499:
1496:
1494:
1491:
1488:
1485:
1482:
1479:
1476:
1473:
1470:
1469:
1467:
1455:
1451:
1448:
1444:
1441:
1438:
1435:
1432:
1429:
1425:
1422:
1419:
1416:
1413:
1409:
1405:
1402:
1399:
1396:
1393:
1389:
1386:
1383:
1379:
1375:
1371:
1368:
1365:
1361:
1357:
1353:
1352:pyrimethamine
1349:
1346:
1343:
1340:
1337:
1336:Sulfonylureas
1334:
1331:
1330:acenocoumarol
1327:
1323:
1320:
1316:
1312:
1308:
1305:
1301:
1297:
1294:
1292:
1288:
1285:
1282:
1281:hyperkalaemic
1278:
1274:
1270:
1266:
1262:
1258:
1255:
1254:
1252:
1240:
1236:
1233:
1229:
1226:
1223:
1220:
1219:
1217:
1209:
1207:
1206:breastfeeding
1203:
1199:
1197:
1192:
1188:
1184:
1180:
1174:
1164:
1156:
1154:
1153:breastfeeding
1149:
1147:
1143:
1139:
1135:
1134:organogenesis
1125:
1123:
1119:
1118:
1113:
1109:
1108:
1099:
1098:
1094:
1091:
1087:
1086:
1082:
1080:
1079:
1075:
1072:
1068:
1067:
1063:
1060:
1056:
1055:
1051:
1048:
1047:toxoplasmosis
1044:
1043:
1039:
1037:
1036:
1032:
1030:
1029:
1025:
1023:
1022:
1018:
1016:
1015:
1011:
1009:
1008:
1004:
1002:
1001:
997:
995:
994:
990:
988:
987:
983:
980:
979:
975:
972:
971:
967:
965:
964:
959:
955:
952:
951:typhoid fever
948:
947:
943:
941:
940:
936:
934:
933:
929:
927:
926:
922:
920:
919:
915:
913:
912:
908:
906:
905:
901:
898:
897:
893:
890:
886:
885:
881:
878:
874:
873:
869:
866:
862:
861:
857:
855:
854:
850:
848:
847:
843:
840:
836:
835:
831:
828:
827:
823:
821:
820:
816:
814:
813:
809:
806:
805:
801:
799:
798:
794:
792:
790:
786:
784:
783:
779:
776:
775:
771:
768:
767:
763:
760:
759:
755:
753:
752:
748:
745:
744:
740:
737:
733:
732:
728:
725:
721:
720:
716:
714:
713:
709:
706:
705:
701:
698:
694:
693:
689:
687:
686:
682:
679:
678:
677:Achromobacter
673:
672:
668:
665:
664:
660:
657:
656:
655:Acinetobacter
652:
651:
649:
641:
639:
635:
631:
627:
623:
619:
615:
611:
607:
606:immune system
603:
599:
597:
588:
583:
581:
580:to use folate
577:
567:
561:
557:
552:
550:
546:
542:
538:
537:toxoplasmosis
534:
530:
526:
522:
518:
514:
510:
506:
502:
498:
495:
491:
487:
477:
470:
462:
458:
457:DTXSID0032233
454:
453:
451:
442:
438:
431:
427:
426:
424:
422:
418:
411:
407:
406:
404:
402:
398:
391:
387:
386:
384:
382:
378:
371:
367:
366:
364:
362:
358:
351:
347:
346:
344:
337:
333:
326:
322:
321:
319:
317:
313:
308:
302:
292:
289:
279:
277:
268:
265:
255:
254:
252:
250:
246:
241:
233:
228:
223:
218:
215:
214:
212:
210:
206:
203:
199:
196:
194:
188:
182:
173:
172:
170:
168:
162:
155:
150:
141:
140:
138:
136:
132:
128:
124:
122:
118:
114:
105:
101:
97:
93:
91:
87:
84:Clinical data
82:
79:
76:
73:
71:
67:
64:
61:
59:
55:
50:
43:
38:
30:
19:
6721:tetracycline
6614:/piperaquine
6570:pyronaridine
6550:tetracycline
6450:Sulfonamides
6425:
6383:halofantrine
6374:+ artemether
6369:lumefantrine
6246:Aconoidasida
6222:sulfadiazine
6198:
6191:Isosporiasis
6180:nitazoxanide
6173:
6016:Lipiarmycins
5863:Sarafloxacin
5853:Orbifloxacin
5838:Enrofloxacin
5828:Danofloxacin
5801:Sitafloxacin
5781:Moxifloxacin
5776:Gemifloxacin
5771:Finafloxacin
5766:Gatifloxacin
5761:Delafloxacin
5756:Besifloxacin
5738:Tosufloxacin
5733:Temafloxacin
5728:Sparfloxacin
5723:Pazufloxacin
5713:Balofloxacin
5708:Levofloxacin
5667:Nadifloxacin
5662:Lomefloxacin
5488:
5482:Combinations
5464:Sulfametrole
5449:Sulfaclozine
5355:Sulfadiazine
5263:Short-acting
5248:Sulfonamides
5236:Trimethoprim
5110:. Retrieved
5096:
5084:. Retrieved
5064:
5052:. Retrieved
5043:
5034:
5022:. Retrieved
5012:
4978:(1): 44–46.
4975:
4971:
4961:
4934:
4930:
4920:
4885:
4881:
4871:
4844:
4840:
4830:
4795:
4791:
4781:
4748:
4744:
4738:
4705:
4701:
4694:
4664:(1): e1–e4.
4661:
4657:
4651:
4606:
4602:
4592:
4557:
4554:HIV Medicine
4553:
4543:
4510:
4506:
4500:
4473:
4469:
4459:
4424:
4420:
4410:
4383:
4379:
4369:
4334:
4330:
4320:
4285:
4281:
4271:
4236:
4232:
4222:
4187:
4183:
4173:
4146:
4142:
4132:
4099:
4095:
4089:
4054:
4050:
4040:
4005:
4001:
3991:
3958:
3954:
3948:
3913:
3909:
3899:
3887:. Retrieved
3878:
3872:
3864:
3829:
3825:
3815:
3780:
3776:
3766:
3731:
3727:
3717:
3692:
3688:
3681:
3656:
3652:
3645:
3618:
3614:
3604:
3579:
3575:
3569:
3544:
3540:
3533:
3500:
3496:
3489:
3446:
3442:
3435:
3425:12 September
3423:. Retrieved
3390:
3386:
3376:
3351:
3347:
3341:
3313:
3302:
3290:. Retrieved
3281:
3272:
3255:
3251:
3245:
3220:
3217:Chemotherapy
3216:
3210:
3178:(1): 72–90.
3175:
3171:
3161:
3128:
3124:
3117:
3103:(8): 491–3.
3100:
3096:
3090:
3071:
3065:
3044:
3036:
3024:. Retrieved
3015:
3006:
2997:
2990:. Retrieved
2936:
2932:
2922:
2895:
2891:
2881:
2856:
2852:
2846:
2834:. Retrieved
2822:
2810:
2777:
2773:
2742:. Retrieved
2733:
2701:. Retrieved
2688:
2664:. Retrieved
2660:
2651:
2639:. Retrieved
2630:
2621:
2609:. Retrieved
2589:
2570:10665/371090
2560:
2551:
2532:
2509:. Retrieved
2500:
2476:. Retrieved
2467:
2439:. Retrieved
2425:
2413:. Retrieved
2404:
2370:. Retrieved
2325:. Retrieved
2316:
2307:
2294:
2189:
2182:
2149:pneumocystis
2148:
2145:pneumocystis
2144:
2123:
2085:Isosporiasis
2075:
2048:
2044:
2031:Tuberculosis
2021:
2015:
2011:
1994:
1884:
1825:Otitis media
1701:Legal status
1673:Trimethoprim
1606:
1602:
1599:
1594:
1588:
1581:
1574:
1568:
1555:
1544:Pharmacology
1539:
1513:
1465:
1449:) inhibited.
1408:azathioprine
1388:Procainamide
1360:methotrexate
1250:
1247:Interactions
1215:
1195:
1185:, rash, and
1176:
1162:
1150:
1142:spina bifida
1131:
1115:
1105:
1103:
1095:
1083:
1076:
1064:
1052:
1040:
1033:
1026:
1019:
1012:
1005:
998:
991:
984:
976:
968:
961:
944:
937:
930:
923:
916:
909:
902:
894:
882:
870:
865:tuberculosis
858:
851:
844:
832:
824:
817:
810:
802:
797:Hafnia alvei
795:
787:
780:
774:Enterococcus
772:
766:Enterobacter
764:
756:
749:
741:
729:
717:
710:
702:
690:
683:
675:
669:
661:
653:
647:
638:Pneumocystis
637:
634:Pneumocystis
633:
626:Pneumocystis
625:
602:Pneumocystis
601:
595:
592:
586:
573:
570:Medical uses
553:
505:trimethoprim
489:
485:
484:
473:
249:Legal status
243:Legal status
135:License data
70:Trimethoprim
29:
6770:from market
6689:clindamycin
6575:piperaquine
6560:clindamycin
6555:doxycycline
6544:+ proguanil
6509:artemisinin
6458:sulfadoxine
6419:cycloguanil
6397:Antifolates
6327:tafenoquine
6301:chloroquine
6296:amodiaquine
6263:Individual
6227:clindamycin
6175:thiazolides
6150:Conoidasida
6049:from market
6024:Fidaxomicin
5996:Rifapentine
5949:Secnidazole
5942:derivatives
5883:Nemonoxacin
5843:Ibafloxacin
5791:Garenoxacin
5680:Norfloxacin
5530:Solasulfone
5469:Sulfanitran
5423:Sulfamazone
5383:Sulfadoxine
5370:Long-acting
5360:Sulfamoxole
5231:Tetroxoprim
5211:Brodimoprim
5188:DNA and RNA
5176:Antifolates
3292:26 February
2836:12 February
2816:"Tularemia"
2703:30 December
2511:28 December
2478:28 December
2441:29 December
2415:28 December
2279:Teva-Trimel
2239:Primotren (
2236:Novo-Trimel
2179:Brand names
1975:Shigellosis
1947:doxycycline
1932:Melioidosis
1815:count, and
1713:Indication
1571:sulfonamide
1434:Ciclosporin
1378:zalcitabine
1348:Antifolates
1315:methenamine
1273:perindopril
1112:mycoplasmae
956:Non-typhi (
839:listeriosis
789:Haemophilus
758:Citrobacter
736:melioidosis
671:Alcaligenes
430:ChEMBL58061
310:Identifiers
202:intravenous
99:Other names
90:Trade names
6823:Categories
6681:Babesiosis
6612:arterolane
6540:atovaquone
6519:artesunate
6504:artemether
6427:biguanides
6343:mefloquine
6317:primaquine
6275:inhibitors
6232:atovaquone
5986:Rifampicin
5973:Rifamycins
5931:inhibitors
5912:Novobiocin
5888:Ozenoxacin
5833:Difloxacin
5820:Veterinary
5690:Rufloxacin
5685:Pefloxacin
5657:Fleroxacin
5590:Flumequine
5560:DNA gyrase
5549:Quinolones
5408:Sulfaperin
5221:Ormetoprim
5190:synthesis)
5054:1 February
4427:(1): 1–8.
3464:1874/25986
3443:Pediatrics
2744:13 January
2666:14 January
2641:14 January
2299:References
2211:Sumetrolim
1999:infections
1817:viral load
1645:Excretion
1506:Drowsiness
1454:creatinine
1404:Nucleoside
1392:amantadine
1382:zidovudine
1374:lamivudine
1370:Antivirals
1319:rifampicin
1304:dofetilide
1300:amiodarone
1287:Prilocaine
1269:lisinopril
1171:See also:
1122:tularaemia
963:Salmonella
877:gonorrhoea
826:Legionella
497:antibiotic
410:CHEBI:3770
361:ChemSpider
316:CAS Number
6780:Phase III
6768:Withdrawn
6565:mepacrine
6514:artemotil
6463:sulfalene
6438:proguanil
6353:quinidine
6322:pamaquine
6059:Phase III
6047:Withdrawn
6006:Rifalazil
6001:Rifaximin
5991:Rifabutin
5965:synthesis
5926:Anaerobic
5897:Related (
5647:Ofloxacin
5615:Rosoxacin
5585:Cinoxacin
5535:Sulfoxone
5388:Sulfalene
5311:Prontosil
5112:17 August
5044:Drugs.com
3889:8 January
3881:. WebMD.
2992:31 August
2802:209121818
2317:Drugs.com
2291:Economics
2276:Sulfatrim
2126:pneumonia
1955:Pertussis
1809:mortality
1805:morbidity
1803:study on
1616:Component
1486:Confusion
1477:Dizziness
1424:Diuretics
1398:Clozapine
1356:proguanil
1342:Phenytoin
1265:enalapril
1261:captopril
1232:porphyria
1224:Pregnancy
1202:pregnancy
1198:infection
1189:. Severe
743:Chlamydia
697:pertussis
663:Aeromonas
618:bacterial
598:pneumonia
589:pneumonia
325:8064-90-2
191:Routes of
165:Pregnancy
127:Monograph
121:Drugs.com
78:inhibitor
6813:Medicine
6735:Stramen-
6496:lactones
6273:Hemozoin
5652:Enoxacin
5439:Mafenide
5216:Iclaprim
5106:Archived
5077:Archived
5048:Archived
5004:21799577
4953:20194044
4912:22240685
4904:19346380
4863:12652396
4773:13621055
4730:40999772
4686:42371307
4678:21102354
4643:23451110
4603:PLOS ONE
4584:26120155
4576:18257775
4535:24695700
4527:24129033
4492:20361847
4451:11139188
4402:23100498
4361:22825115
4312:19564358
4263:22869580
4214:21930870
4165:20507860
4116:19423463
4081:18411321
4032:17502411
3983:31546680
3975:15767239
3940:20687081
3883:Archived
3873:Shigella
3856:17636756
3847:11322855
3807:24284287
3758:23033403
3709:11425157
3637:11803509
3525:45262990
3517:11303827
3481:23835227
3473:17473089
3419:Archived
3415:23402992
3407:15488218
3286:Archived
3153:19395548
3145:24259630
3109:24156179
3026:19 April
3020:Archived
2986:Archived
2963:21014782
2955:21749628
2914:21345707
2873:23805970
2827:Archived
2738:Archived
2697:Archived
2661:ClinCalc
2635:Archived
2631:ClinCalc
2611:30 March
2605:Archived
2559:(2023).
2505:Archived
2501:DailyMed
2472:Archived
2435:Archived
2409:Archived
2372:1 August
2366:Archived
2327:15 April
2321:Archived
2256:Septra (
2245:Slovenia
2220:Deprim (
2208:Biseptol
2045:In vitro
2012:In vitro
1913:Listeria
1813:CD4-cell
1480:Headache
1474:Vomiting
1462:Overdose
1326:warfarin
1277:ramipril
1187:diarrhea
1183:vomiting
1140:such as
978:Shigella
970:Serratia
896:Nocardia
804:Kingella
724:glanders
704:Brucella
610:HIV/AIDS
541:HIV/AIDS
476:(verify)
209:ATC code
167:category
149:DailyMed
6590:nations
6348:quinine
6255:Malaria
6139:Apicom-
5558:and/or
5525:Dapsone
4995:3139289
4822:9624473
4765:1396726
4722:8610948
4634:3579948
4611:Bibcode
4352:3457372
4303:2772331
4254:3486608
4205:3232808
4124:8425281
4072:2415789
4023:1913240
3931:6532574
3798:3939931
3749:3516270
3596:2403603
3561:3541724
3368:8195839
3282:PubChem
3264:4902845
3237:4908562
3202:5301731
3193:1570262
2794:6759092
2250:Resprim
2104:Malaria
2049:in vivo
2016:in vivo
1801:Ugandan
1595:de novo
1576:de novo
1558:synergy
1418:Digoxin
1390:and/or
1311:dapsone
1283:effects
1237:Severe
1071:cholera
608:, like
576:to make
529:cholera
490:Bactrim
336:PubChem
274::
229: (
227:J04AM08
225:)
219: (
217:J01EE01
180: C
151::
18:Bactrim
6799:Portal
6763:WHO-EM
6707:Cilio-
6626:(ASMQ)
6620:(ASAQ)
6588:Combi-
6265:agents
6128:Alveo-
6042:WHO-EM
5086:1 June
5024:4 June
5020:. NICE
5002:
4992:
4951:
4910:
4902:
4861:
4820:
4813:105601
4810:
4771:
4763:
4728:
4720:
4684:
4676:
4641:
4631:
4582:
4574:
4533:
4525:
4490:
4449:
4439:
4400:
4359:
4349:
4310:
4300:
4261:
4251:
4212:
4202:
4163:
4122:
4114:
4079:
4069:
4030:
4020:
3981:
3973:
3938:
3928:
3854:
3844:
3805:
3795:
3777:Lancet
3756:
3746:
3707:
3673:150980
3671:
3635:
3594:
3559:
3523:
3515:
3479:
3471:
3413:
3405:
3387:Lancet
3366:
3329:
3262:
3235:
3200:
3190:
3151:
3143:
3107:
3078:
3053:
2961:
2953:
2912:
2871:
2800:
2792:
2597:
2539:
2282:Trisul
2217:Cotrim
1689:Renal
1683:42-45%
1667:Renal
1493:Uremia
1471:Nausea
1275:, and
1179:nausea
1159:Babies
1110:, the
564:
545:orally
527:, and
421:ChEMBL
390:D00285
370:318412
350:358641
301:℞-only
299:
286:
276:℞-only
262:
147:
6737:opile
6709:phora
6533:Other
6362:Other
6141:plexa
5157:that
5080:(PDF)
5073:(PDF)
4908:S2CID
4769:S2CID
4726:S2CID
4682:S2CID
4580:S2CID
4531:S2CID
4442:96003
4120:S2CID
3979:S2CID
3521:S2CID
3477:S2CID
3411:S2CID
3149:S2CID
3016:WebMD
2959:S2CID
2830:(PDF)
2819:(PDF)
2798:S2CID
2774:Drugs
2693:(CDC)
2689:U.S.
2468:(emc)
2197:Roche
1503:Colic
1350:like
1298:like
1259:like
401:ChEBI
6599:ACTs
6481:(SP)
6313:(8-)
6292:(4-)
6130:late
5167:J01M
5163:J01E
5114:2015
5088:2018
5056:2018
5026:2024
5000:PMID
4949:PMID
4900:PMID
4859:PMID
4818:PMID
4761:PMID
4718:PMID
4674:PMID
4639:PMID
4572:PMID
4523:PMID
4488:PMID
4447:PMID
4398:PMID
4357:PMID
4308:PMID
4259:PMID
4210:PMID
4161:PMID
4112:PMID
4077:PMID
4028:PMID
3971:PMID
3936:PMID
3914:2010
3891:2014
3852:PMID
3830:2013
3803:PMID
3754:PMID
3705:PMID
3669:PMID
3633:PMID
3592:PMID
3576:JAMA
3557:PMID
3513:PMID
3469:PMID
3427:2020
3403:PMID
3364:PMID
3327:ISBN
3294:2018
3260:PMID
3233:PMID
3198:PMID
3141:PMID
3105:PMID
3076:ISBN
3051:ISBN
3028:2019
2994:2015
2951:PMID
2933:BJOG
2910:PMID
2869:PMID
2838:2014
2790:PMID
2746:2014
2705:2021
2668:2024
2643:2024
2613:2020
2595:ISBN
2537:ISBN
2513:2021
2480:2021
2443:2021
2417:2021
2374:2015
2329:2020
2047:and
2014:and
1765:COPD
1753:MHRA
1664:8-10
1556:The
1410:and
1358:and
1328:and
1193:and
1114:and
981:spp.
973:spp.
899:spp.
829:spp.
807:spp.
791:spp.
777:spp.
769:spp.
761:spp.
746:spp.
707:spp.
680:spp.
666:spp.
658:spp.
620:and
578:and
535:and
381:KEGG
198:oral
117:AHFS
6119:P01
5963:RNA
5928:DNA
4990:PMC
4980:doi
4939:doi
4890:doi
4849:doi
4808:PMC
4800:doi
4753:doi
4710:doi
4706:124
4666:doi
4629:PMC
4619:doi
4562:doi
4515:doi
4478:doi
4474:102
4437:PMC
4429:doi
4388:doi
4347:PMC
4339:doi
4298:PMC
4290:doi
4249:PMC
4241:doi
4200:PMC
4192:doi
4151:doi
4104:doi
4067:PMC
4059:doi
4018:PMC
4010:doi
3963:doi
3926:PMC
3918:doi
3842:PMC
3834:doi
3793:PMC
3785:doi
3781:383
3744:PMC
3736:doi
3697:doi
3661:doi
3657:157
3623:doi
3584:doi
3580:263
3549:doi
3545:106
3505:doi
3459:hdl
3451:doi
3447:119
3395:doi
3391:364
3356:doi
3319:doi
3225:doi
3188:PMC
3180:doi
3133:doi
2941:doi
2937:118
2900:doi
2861:doi
2782:doi
2565:hdl
2243:in
2241:Lek
2169:Yes
2161:Yes
2136:Yes
2133:Yes
2130:Yes
1982:Yes
1979:Yes
1939:Yes
1920:Yes
1876:Yes
1870:Yes
1851:Yes
1837:Yes
1785:HIV
1769:Yes
1739:TGA
1725:FDA
1680:130
1677:1-4
1661:66%
1655:1-4
1642:(h)
1640:1/2
1632:(L)
1623:(h)
1621:max
1124:).
446:EPA
340:CID
288:POM
232:WHO
222:WHO
104:BAN
6825::
6776::
6747::
6719::
6315::
6294::
6113:–
6109:–
6055::
5910::
5899:DG
5324:,
5165:,
5104:.
5046:.
5042:.
4998:.
4988:.
4976:32
4974:.
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