215:
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164:
hemostats are topical agents composed of chitosan and its salts. Chitosan bonds with platelets and red blood cells to form a gel-like clot which seals a bleeding vessel. Unlike other hemostat technologies its action does not require the normal hemostatic pathway and therefore continues to function
149:
hemostat (MCH) is a topical agent composed of resorbable microfibrillar collagen. It attracts platelets and allows for the formation of a blood clot when it comes into contact with blood. Unlike the hemostatic clamp, no mechanical action is involved. The surgeon presses the MCH against a bleeding
82:
Hemostatic agents are used during surgical procedures to achieve hemostasis and are categorized as hemostats, sealants and adhesives. They vary based on their mechanism of action, composition, ease of application, adherence to tissue, immunogenicity and cost. These agents permit rapid hemostasis,
275:
were invented, a styptic pencil was a standard part of a shaving kit and was used to seal shaving cuts. Some people continue to use styptic pencils for minor skin wounds from safety or electric razors.
351:
664:
334:
557:"Chitosan arrests bleeding in major hepatic injuries with clotting dysfunction: an in vivo experimental study in a model of hepatic injury in the presence of moderate systemic heparinisation"
612:
83:
better visualization of the surgical area, shorter operative times, decreased requirement for transfusions, decreased wound healing time and overall improvement in patient recovery time.
168:
Chitosan is used in some emergency hemostats which are designed to stop traumatic life-threatening bleeding. Their use is well established in many military and trauma units.
445:
641:
2123:
1203:
1171:
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is the main ingredient and acts as a vasoconstrictor in order to disable blood flow. The stick is applied directly to the bleeding site. The high
2180:
620:
685:
1193:
710:
1974:
757:
1934:
1070:
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1547:
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in it) activate the coagulation cascade, and have been used as the active component of hemostatic dressings (for example, in
1834:
1827:
669:
356:
339:
1577:
1440:
1201:
648:
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trade to stop bleeding from nails that are clipped too closely. This powder is generally used on animals, such as
1730:
1186:
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943:
128:. They are available in three forms—as a granular powder poured on wounds, as a styptic pencil or embedded in a
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site, and the collagen attracts and helps with the clotting process to eventually stop bleeding.
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1537:
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A common delivery system for this is a styptic or hemostatic pencil (not to be confused with a
433:
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718:
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70:
8:
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There are several classes of antihemorrhagic drugs used in medicine. These include
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234:
66:
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The practical application for MCH is different from that of the hemostatic clamp.
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2010:
2005:
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of the blood, and the astringent chemical causes local vasoconstriction. Before
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55:
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Antihemorrhagic agents used in medicine have various mechanisms of action:
1949:
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1158:
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994:
929:
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784:
735:
59:
233:) is a specific type of antihemorrhagic agent that works by contracting
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2020:
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32:
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2015:
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1964:
1899:
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1705:
1618:
1492:
1133:
881:
818:
801:
257:
109:
613:"Military Experts Say Newer Hemostatic Dressings Beat Gauze // ACEP"
2136:
2000:
1996:
1969:
1408:
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1260:
1148:
1075:
1046:
919:
914:
310:
195:
161:
146:
36:
120:
Topical hemostatic agents have been gaining popularity for use in
2112:
2030:
1695:
1462:
1284:
1234:
191:
555:
Millner, Russell; Lockhart, Alan S; Marr, Rebecca (2010-10-01).
1794:
1457:
1127:
292:
187:
206:
2094:
1804:
1299:
686:"Styptic Pencil what is it, how to use at Executive Shaving"
1798:
218:
371:"Comparison of hemostatic agents used in vascular surgery"
420:
Pharmacology ReCap 2.0 for
Bachelor of Dentistry Students
288:
284:
474:
Sundaram, Chandru P.; Keenan, Alison C. (2010-01-01).
1204:
688:. Executive-shaving.co.uk. 2015-08-21. Archived from
476:"Evolution of hemostatic agents in surgical practice"
642:"HOW QUIKCLOT BRAND PRODUCTS WORK TO STOP BLEEDING"
554:
536:
Film forming personal care compositions and methods
165:even when anticoagulants like heparin are present.
561:Annals of the Royal College of Surgeons of England
369:Vyas, Krishna S; Saha, Sibu P (22 October 2013).
295:, whose vein is found in the center of the nail.
65:Locally acting hemostatic agents work by causing
2209:
473:
1187:
751:
1202:Major chemical drug groups – based upon the
1194:
1180:
765:
758:
744:
140:
1071:Tetragalacturonic acid hydroxymethylester
588:
509:
491:
394:
368:
213:
205:
680:
678:
2210:
2181:Pharmacological classification systems
1548:Selective estrogen receptor modulators
647:. Z-Medica Corporation. Archived from
446:"When to use hemostatic agents in EMS"
1828:Non-steroidal anti-inflammatory drugs
1175:
739:
176:
31:) agent is a substance that promotes
675:
532:
375:Expert Opinion on Biological Therapy
1441:Angiotensin II receptor antagonists
13:
54:Systemic drugs work by inhibiting
14:
2239:
946:(II, VII, IX, X, protein C and S)
2190:
2170:
2169:
573:10.1308/003588410X12699663903593
1578:Hypothalamic–pituitary hormones
989:thrombopoietin receptor agonist
944:Prothrombin complex concentrate
703:
658:
634:
605:
533:Dong, Shaosheng (Nov 6, 2014),
423:. Quick Review of Pharmacology.
77:
1081:Hemostatic Powder Spray TC-325
548:
526:
467:
438:
427:
411:
362:
345:
328:
316:Hemostatic Powder Spray TC-325
279:Styptic powder is used in the
1:
1330:Thrombolytics / fibrinolytics
321:
39:). It may also be known as a
16:Substance that stops bleeding
2041:Wakefulness-promoting agents
711:"Pet first-aid kit contents"
670:Dorland's Medical Dictionary
387:10.1517/14712598.2013.848193
357:Dorland's Medical Dictionary
340:Dorland's Medical Dictionary
252:). This is a short stick of
171:
28:
7:
434:Styptic Pencil (definition)
298:
201:
156:
91:
10:
2244:
1691:Intravenous immunoglobulin
876:Valoctocogene roxaparvovec
241:. Styptic pencils contain
183:contact activation pathway
180:
135:
122:emergency bleeding control
2165:
2121:
2093:
2049:
1858:
1793:
1756:
1704:
1617:
1561:
1521:
1478:
1362:
1298:
1210:
1093:
1037:Absorbable gelatin sponge
1029:
953:
831:
800:
793:
778:
480:Indian Journal of Urology
1746:Topoisomerase inhibitors
1430:renin–angiotensin system
1424:Calcium channel blockers
886:Fidanacogene elaparvovec
115:
86:
1120:Aminomethylbenzoic acid
493:10.4103/0970-1591.70574
141:Microfibrillar collagen
1538:Hormonal contraception
1468:Bile acid sequestrants
1249:Proton-pump inhibitors
1212:gastrointestinal tract
222:
211:
852:Damoctocog alfa pegol
654:on 23 September 2014.
217:
209:
2228:Transfusion medicine
2147:Radiopharmaceuticals
1935:Antiparkinson agents
71:platelet aggregation
1930:Antimigraine agents
1920:Antidementia agents
1823:Anti-inflammatories
1513:Medicated dressings
1453:Antihyperlipidemics
1280:Diabetes medication
715:www.vet.cornell.edu
102:coagulation factors
1783:Immunosuppressants
1653:Antimycobacterials
1609:Antithyroid agents
1593:Mineralocorticoids
1397:Cardiac stimulants
1387:Cardiac glycosides
1379:cardiac therapy /
1275:Anti-obesity drugs
1066:Oxidized cellulose
856:Efanesoctocog alfa
307:– Antihemorrhagics
223:
212:
177:Contact activation
2205:
2204:
2108:Ophthalmologicals
1818:Anabolic steroids
1721:Anticancer agents
1684:Ectoparasiticides
1404:Antihypertensives
1352:Antifibrinolytics
1169:
1168:
1139:Alfa1 antitrypsin
1110:Aminocaproic acid
1095:Antifibrinolytics
1089:
1088:
1025:
1024:
860:Efmoroctocog alfa
810:Phytomenadione (K
381:(12): 1663–1672.
335:"antihemorrhagic"
261:aluminium sulfate
126:military medicine
98:antifibrinolytics
2235:
2218:Antihemorrhagics
2194:
2173:
2172:
2157:Senotherapeutics
2011:Neuroprotectives
2006:Mood stabilizers
1905:Anti-ADHD agents
1845:Muscle relaxants
1778:Immunostimulants
1773:Immunomodulators
1605:Thyroid hormones
1543:Fertility agents
1446:Renin inhibitors
1337:Antihemorrhagics
1304:forming organs (
1290:Dietary minerals
1196:
1189:
1182:
1173:
1172:
1042:Calcium alginate
798:
797:
791:
790:
780:Antihemorrhagics
767:Antihemorrhagics
760:
753:
746:
737:
736:
730:
729:
727:
726:
717:. Archived from
707:
701:
700:
698:
697:
682:
673:
662:
656:
655:
653:
646:
638:
632:
631:
629:
628:
619:. Archived from
609:
603:
602:
592:
552:
546:
545:
544:
543:
530:
524:
523:
513:
495:
471:
465:
464:
462:
461:
452:. Archived from
442:
436:
431:
425:
424:
415:
409:
408:
398:
366:
360:
349:
343:
332:
311:Hemostatic clamp
237:to seal injured
124:, especially in
67:vasoconstriction
30:
29:antihaemorrhagic
2243:
2242:
2238:
2237:
2236:
2234:
2233:
2232:
2208:
2207:
2206:
2201:
2197:Medicine portal
2161:
2117:
2089:
2084:
2076:Cough medicines
2071:Bronchodilators
2052:
2045:
1925:Antidepressants
1915:Anticonvulsants
1863:
1854:
1850:Bisphosphonates
1840:Corticosteroids
1802:
1789:
1761:
1752:
1736:Spindle poisons
1726:Antimetabolites
1709:
1700:
1622:
1613:
1588:Glucocorticoids
1583:Corticosteroids
1564:
1557:
1524:
1517:
1474:
1392:Antiarrhythmics
1365:
1358:
1315:Antithrombotics
1303:
1294:
1270:Antipropulsives
1266:Antidiarrhoeals
1243:
1214:
1206:
1200:
1170:
1165:
1115:Tranexamic acid
1085:
1021:
955:
949:
872:Turoctocog alfa
868:Susoctocog alfa
864:Moroctocog alfa
834:
827:
822:
813:
782:
774:
764:
734:
733:
724:
722:
709:
708:
704:
695:
693:
684:
683:
676:
663:
659:
651:
644:
640:
639:
635:
626:
624:
611:
610:
606:
553:
549:
541:
539:
531:
527:
472:
468:
459:
457:
444:
443:
439:
432:
428:
417:
416:
412:
367:
363:
350:
346:
333:
329:
324:
301:
221:block and razor
204:
185:
179:
174:
159:
145:Microfibrillar
143:
138:
118:
94:
89:
80:
25:British English
21:antihemorrhagic
17:
12:
11:
5:
2241:
2231:
2230:
2225:
2220:
2203:
2202:
2200:
2199:
2188:
2183:
2178:
2166:
2163:
2162:
2160:
2159:
2154:
2149:
2144:
2142:Contrast media
2139:
2133:
2131:
2119:
2118:
2116:
2115:
2110:
2104:
2102:
2095:sensory organs
2091:
2090:
2088:
2087:
2082:
2078:
2073:
2068:
2062:
2060:
2047:
2046:
2044:
2043:
2038:
2033:
2028:
2023:
2018:
2013:
2008:
2003:
1994:
1993:
1992:
1987:
1982:
1972:
1967:
1962:
1957:
1952:
1947:
1942:
1940:Antipsychotics
1937:
1932:
1927:
1922:
1917:
1912:
1910:Antiaddictives
1907:
1902:
1897:
1896:
1895:
1890:
1880:
1874:
1872:
1865:nervous system
1856:
1855:
1853:
1852:
1847:
1842:
1837:
1835:Antirheumatics
1832:
1831:
1830:
1820:
1814:
1812:
1791:
1790:
1788:
1787:
1786:
1785:
1780:
1769:
1767:
1754:
1753:
1751:
1750:
1749:
1748:
1743:
1741:Antineoplastic
1738:
1733:
1728:
1717:
1715:
1702:
1701:
1699:
1698:
1693:
1688:
1687:
1686:
1681:
1676:
1674:Antiprotozoals
1669:Antiparasitics
1666:
1661:
1656:
1649:Antibacterials
1645:Antimicrobials
1641:
1639:
1615:
1614:
1612:
1611:
1602:
1597:
1596:
1595:
1590:
1580:
1574:
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1555:
1550:
1545:
1540:
1534:
1532:
1519:
1518:
1516:
1515:
1510:
1508:Antipsoriatics
1505:
1500:
1495:
1489:
1487:
1476:
1475:
1473:
1472:
1471:
1470:
1465:
1460:
1450:
1449:
1448:
1443:
1438:
1436:ACE inhibitors
1426:
1421:
1416:
1411:
1406:
1401:
1400:
1399:
1394:
1389:
1375:
1373:
1364:cardiovascular
1360:
1359:
1357:
1356:
1355:
1354:
1349:
1344:
1334:
1333:
1332:
1327:
1325:Anticoagulants
1322:
1311:
1309:
1296:
1295:
1293:
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1287:
1282:
1277:
1272:
1263:
1258:
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1237:
1226:
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1199:
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1184:
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1153:
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1083:
1078:
1073:
1068:
1063:
1058:
1049:
1044:
1039:
1033:
1031:
1027:
1026:
1023:
1022:
1020:
1019:
1018:
1017:
1012:
1007:
1002:
997:
985:
980:
975:
970:
965:
959:
957:
951:
950:
948:
947:
937:
936:
927:
922:
917:
908:
907:
894:
893:
879:
845:
839:
837:
829:
828:
826:
825:
820:
816:
811:
806:
804:
795:
788:
776:
775:
763:
762:
755:
748:
740:
732:
731:
702:
674:
657:
633:
604:
567:(7): 559–561.
547:
525:
486:(3): 374–378.
466:
437:
426:
410:
361:
344:
326:
325:
323:
320:
319:
318:
313:
308:
300:
297:
265:ionic strength
250:caustic pencil
229:(also spelled
210:Styptic pencil
203:
200:
178:
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170:
158:
155:
142:
139:
137:
134:
117:
114:
93:
90:
88:
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79:
76:
75:
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63:
43:(also spelled
15:
9:
6:
4:
3:
2:
2240:
2229:
2226:
2224:
2221:
2219:
2216:
2215:
2213:
2198:
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2179:
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2167:
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2158:
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2148:
2145:
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2135:
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2125:
2120:
2114:
2111:
2109:
2106:
2105:
2103:
2100:
2096:
2092:
2086:
2079:
2077:
2074:
2072:
2069:
2067:
2066:Decongestants
2064:
2063:
2061:
2058:
2054:
2048:
2042:
2039:
2037:
2034:
2032:
2029:
2027:
2024:
2022:
2019:
2017:
2014:
2012:
2009:
2007:
2004:
2002:
1998:
1995:
1991:
1988:
1986:
1985:Dissociatives
1983:
1981:
1978:
1977:
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1975:Hallucinogens
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1956:
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1948:
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1941:
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1933:
1931:
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1926:
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1918:
1916:
1913:
1911:
1908:
1906:
1903:
1901:
1898:
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1891:
1889:
1886:
1885:
1884:
1881:
1879:
1876:
1875:
1873:
1870:
1866:
1861:
1857:
1851:
1848:
1846:
1843:
1841:
1838:
1836:
1833:
1829:
1826:
1825:
1824:
1821:
1819:
1816:
1815:
1813:
1810:
1806:
1800:
1796:
1792:
1784:
1781:
1779:
1776:
1775:
1774:
1771:
1770:
1768:
1765:
1759:
1755:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1723:
1722:
1719:
1718:
1716:
1713:
1707:
1703:
1697:
1694:
1692:
1689:
1685:
1682:
1680:
1679:Anthelmintics
1677:
1675:
1672:
1671:
1670:
1667:
1665:
1662:
1660:
1657:
1654:
1650:
1646:
1643:
1642:
1640:
1637:
1633:
1629:
1625:
1620:
1616:
1610:
1606:
1603:
1601:
1598:
1594:
1591:
1589:
1586:
1585:
1584:
1581:
1579:
1576:
1575:
1573:
1570:
1566:
1560:
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1523:genitourinary
1520:
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1503:Antipruritics
1501:
1499:
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1015:Rafutrombopag
1013:
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1010:Lusutrombopag
1008:
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998:
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993:
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990:
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968:Carbazochrome
966:
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960:
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941:combinations:
939:
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931:
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721:on 2009-07-29
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692:on 2013-09-01
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456:on 2016-03-15
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69:or promoting
68:
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58:or promoting
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53:
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51:
48:
46:
42:
38:
34:
26:
22:
1980:Psychedelics
1950:Aphrodisiacs
1624:infestations
1600:Sex hormones
1553:Sex hormones
1498:Cicatrizants
1428:
1414:Vasodilators
1381:antianginals
1378:
1336:
1230:stomach acid
1229:
1144:C1-inhibitor
1126:
1102:
1000:Avatrombopag
987:
983:Fostamatinib
940:
934:Catridecacog
925:I/Fibrinogen
911:
905:Eptacog alfa
897:
890:Nonacog alfa
842:
819:Menadione (K
779:
766:
723:. Retrieved
719:the original
714:
705:
694:. Retrieved
690:the original
668:
665:"astringent"
660:
649:the original
636:
625:. Retrieved
621:the original
617:www.acep.org
616:
607:
564:
560:
550:
540:, retrieved
535:
528:
483:
479:
469:
458:. Retrieved
454:the original
449:
440:
429:
419:
413:
378:
374:
364:
355:
347:
338:
330:
305:ATC code B02
278:
269:flocculation
247:
230:
226:
224:
186:
167:
160:
152:
144:
119:
95:
81:
78:Medical uses
56:fibrinolysis
49:
44:
40:
20:
18:
2113:Otologicals
2085:antagonists
2051:respiratory
2026:Orexigenics
2021:Neurotoxins
1970:Euphoriants
1960:Entactogens
1955:Depressants
1945:Anxiolytics
1883:Anesthetics
1659:Antifungals
1256:Antiemetics
1244:antagonists
1159:Ulinastatin
1104:amino acids
1061:Fibrin glue
1052:Epinephrine
1005:Eltrombopag
995:Romiplostim
920:II/Thrombin
833:Coagulation
785:coagulation
243:astringents
60:coagulation
45:haemostatic
2212:Categories
2036:Stimulants
2016:Nootropics
1990:Deliriants
1965:Entheogens
1900:Anorectics
1878:Analgesics
1731:Alkylating
1664:Antivirals
1619:infections
1493:Emollients
1347:Coagulants
1217:metabolism
1056:adrenalone
978:Etamsylate
973:Concizumab
963:Batroxobin
898:extrinsic:
843:intrinsic:
725:2016-03-14
696:2015-10-20
627:2016-03-14
542:2016-03-14
460:2016-03-14
352:"hemostat"
322:References
281:veterinary
254:medication
181:See also:
106:fibrinogen
41:hemostatic
33:hemostasis
2186:ATC codes
2152:Dressings
2137:Antidotes
2001:Sedatives
1997:Hypnotics
1706:malignant
1563:endocrine
1409:Diuretics
1342:Platelets
1302:and blood
1261:Laxatives
1155:unsorted
1134:Aprotinin
802:Vitamin K
581:0035-8843
502:0970-1591
267:promotes
258:Anhydrous
190:(and the
172:Inorganic
110:vitamin K
47:) agent.
2031:Serenics
1696:Vaccines
1463:Fibrates
1285:Vitamins
1235:Antacids
1149:Camostat
1076:Thrombin
1047:Collagen
956:systemic
794:Systemic
599:20522310
520:21116358
405:24144261
299:See also
202:Styptics
196:QuikClot
162:Chitosan
157:Chitosan
147:collagen
130:dressing
100:, blood
92:Systemic
37:bleeding
2223:Shaving
1888:General
1795:muscles
1764:L03–L04
1760:disease
1712:L01–L02
1708:disease
1458:Statins
1128:serpins
912:common:
835:factors
590:3229344
511:2978438
396:4390172
293:rabbits
231:stiptic
227:styptic
192:zeolite
136:Organic
35:(stops
2195:
2174:
2122:other
2053:system
1805:joints
1758:immune
1565:system
1525:system
1366:system
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291:, and
235:tissue
188:Kaolin
108:, and
2176:Drugs
1893:Local
1860:brain
1799:bones
1300:blood
1030:Local
954:Other
652:(PDF)
645:(PDF)
116:Local
87:Types
1803:and
1480:skin
930:XIII
848:VIII
595:PMID
577:ISSN
516:PMID
498:ISSN
450:EMS1
401:PMID
289:dogs
285:cats
219:Alum
2124:ATC
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