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The Allen Brain
Observatory was launched in 2016 to capture cellular-level activity of neurons in the mouse visual cortex. Experiments through the observatory use visual or electrical readouts of neural activity as animals see visual stimuli, ranging from natural images to black and white grid lines
295:, the neuroscientist who led the study, said that, "By using the Allen Spinal Cord Atlas, we were able to discover a brand new cell type that has previously been overlooked and that could be an important player in all manner of spinal cord injury and disease, including multiple sclerosis and ALS."
390:
Launched in 2015, the Allen Cell Types
Database is a new tool to help scientists understand the building blocks of the brain and a major step toward creating a comprehensive map of the brain. The database will help create a common language for researchers around the world to use in observing,
322:
On May 24, 2010, the Allen
Institute announced it was expanding its tools from the mouse into the human brain with the launch of the Allen Human Brain Atlas. This highly comprehensive atlas integrates several kinds of data, including data collected by
195:
in 2003, the institute tackles projects at the leading edge of science—far-reaching projects at the intersection of biology and technology. The resulting data create free, publicly available resources that fuel discovery for countless researchers.
350:(ISH) approaches. The Allen Human Brain Atlas allows researchers to see where a gene is turned on. "The location of where these genes are active is at the very center of understanding how brain diseases work", neurologist Jeffrey L. Noebels told
414:. In 2018, the institute opened the observatory for research projects proposed by scientists from the broader community through a program called OpenScope, which was modeled after large-scale shared physics observatories such as the
212:, launched in 2014. The Paul G. Allen Frontiers Group was launched in 2016 while the Allen Institute for Immunology was launched in 2018. All four divisions of the Allen Institute are housed in the same building in Seattle's
303:
On
November 14, 2008, the Allen Institute for Brain Science announced the launch of the Allen Developing Mouse Brain Atlas, providing a highly detailed map of gene activity in the mouse brain at several time points across
216:
neighborhood. The institute employs a business model that combines the operational agility and accountability of a for-profit enterprise with the founding vision to take on ambitious projects in neuroscience.
252:
in the mouse brain detailing more than 21,000 genes at the cellular level. Since the project's launch, it has been renamed the Allen Mouse Brain Atlas to distinguish it from subsequent atlas projects.
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382:
throughout the mouse brain, designed to help scientists understand how the brain is wired, offering new insights into how the brain works and what goes awry in brain diseases and disorders.
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sorts elements. The first release of data includes information on more than 240 cells in the mouse brain. In 2017, the Allen
Institute added data from human brain cells to the database.
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852:
Jones, Allan R.; Grant, Seth G. N.; Koch, Christof; Smith, Stephen M.; Hof, Patrick R.; Geschwind, Daniel H.; Zielke, H. Ronald; Wohnoutka, Paul; Williams, Derric (September 2012).
599:
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The BrainSpan Atlas of the
Developing Human Brain, a resource for studying human brain development developed by a consortium of scientific partners and funded by awards from the
228:
The Allen
Institute for Brain Science provides researchers and educators with a variety of unique online public resources for exploring the nervous system. Integrating extensive
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The Allen Mouse Brain
Connectivity Atlas was launched online on November 3, 2011, and moved the Allen Institute's mapping efforts beyond its historical focus on
622:
816:
alleninstitute.org, "Allen
Institute for Brain Science launches Allen Human Brain Atlas with first data set charting genes at work in the adult human brain"
459:
Cajal Club – Krieg
Lifetime Achievement Award to Paul Allen for extraordinary contributions in neuroscience through his work with the Allen Institute (2010)
248:
The inaugural project of the Allen Institute was announced on September 26, 2006. Named the Allen Brain Atlas, it was a web-based, three-dimensional map of
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spinal cord. It is set up like the Allen Institute's earlier atlas of the adult mouse brain. The map could help reveal new treatments for human
208:
The Allen Institute for Brain Science is a scientific division of the Allen Institute, a nonprofit research organization that also includes the
806:
Thompson CL, Ng, L, et al. (2014) A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron 83(2):309-23.
1496:
770:
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493:– Special Recognition Award to Paul Allen for his generous contributions to neuroscience through his work with the Allen Institute (2007)
465:– Public Leadership in Neurology Award to Paul Allen for his strong commitment to brain research and work with the Allen Institute (2009)
1006:
220:
In 2012, the institute received an additional pledge of $ 300 million from Paul Allen, bringing his total commitment to $ 500 million.
1213:
473:– "Top 100 Most Influential People in the World" to Paul Allen for his successful achievements at the Allen Institute (2007, 2008)
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549:
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alleninstitute.org, "Allen Institute for Brain Science launches new brain atlas and updates four others with new data and tools"
796:
alleninstitute.org, "Allen Institute for Brain Science launches new atlas resource and enhances others with new data and tools"
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523:"The Allen Institute for Brain Science is a 501 (c) (3) nonprofit medical research organization based in Seattle, Washington"
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In addition to the atlas resources, the Allen Institute has generated several other online research tools, including:
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alleninstitute.org, "Public data release from Allen Institute for Brain Science enhances Allen Brain Atlas resources"
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alleninstitute.org, "Allen Institute for Brain Science announces first comprehensive gene map of the human brain"
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The Allen Spinal Cord Atlas led to the discovery of a new class of cells in the spinal cord that behave like
1482:
1193:
487:– Rave Award to Paul Allen and the Allen Institute for the completion of the Allen Mouse Brain Atlas (2007)
456:– 30 Under 30 Rising Stars Transforming Science and Health to Allen Institute scientist Adrian Cheng (2012)
771:"Science Daily, "New class of stem cell-like cells discovered offers possibility for spinal cord repair""
430:
The Ivy Glioblastoma Atlas Project (Ivy GAP), a platform for exploring the anatomic and genetic basis of
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hybridization data is accompanied by a set of reference atlases drawn by neuroanatomist Luis Puelles.
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650:(Press release). Allen Institute for Brain Science. September 26, 2006. Archived from
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600:"A New Approach to Alzheimer's Disease Research - Allen Institute for Brain Science"
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in different areas, the Allen Institute provides free data and tools to scientists.
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1007:"OpenScope gives neuroscientists time on Allen Institute's telescope for the brain"
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873:
501:– "Top 10 Medical Breakthroughs of the Year" for the Allen Mouse Brain Atlas (2006)
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716:"Gene map charts spinal cord mysteries - Health - Health care - More health news"
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176:. Founded in 2003, it is dedicated to accelerating the understanding of how the
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623:"Biologists Get $ 100 Million From Billionaire Paul Allen To Investigate Cells"
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308:, including four embryonic ages, three postnatal, and aging time points. The
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854:"An anatomically comprehensive atlas of the adult human brain transcriptome"
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982:"When you show a mouse a movie: Allen Institute opens window into brain"
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571:"Allen Institute announces $ 125 million gift to probe human immunology"
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in April 2011. The Allen Human Brain Atlas was profiled in the journal
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956:"Scientists And Surgeons Team Up To Create Virtual Human Brain Cells"
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On July 17, 2008, the Allen Institute for Brain Science launched the
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circuitry. The atlas is a three-dimensional, high-resolution map of
284:. The map points researchers toward places where genes are active.
181:
291:, according to researchers at the University of British Columbia.
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930:"Paul Allen Just Got One Step Closer To Mapping The Human Brain"
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measuring and ultimately sorting cells into types much like the
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648:"Allen Institute for Brain Science completes brain atlas"
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Headquarters of the Allen Institute for Brain Science
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841:, "Atlas Gives Scientists New View of the Brain"
268:Atlas. The spinal cord atlas is an interactive,
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187:Started with $ 100 million in seed money from
1114:
1033:"Home :: Ivy Glioblastoma Atlas Project"
674:"Institute unveils full atlas of mouse brain"
276:is expressed, or "turned on", throughout the
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16:Research institute based in Seattle, WA, USA
1421:Allen Institute for Artificial Intelligence
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180:works. With the intent of catalyzing brain
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200:is the current director of the institute.
134:(chief scientist of the Mindscope Program)
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1536:Non-profit organizations based in Seattle
1214:Flying Heritage & Combat Armor Museum
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1086:"Scientists Map the Brain, Gene by Gene"
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479:– "Top Ten Medical Breakthroughs" (2006)
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550:Allen Institute For Brain Science/The
434:at the cellular and molecular levels.
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746:"MapQuest For The Mouse Spinal Cord"
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366:Allen Mouse Brain Connectivity Atlas
13:
954:Hamilton, Jon (October 25, 2017).
928:Weintraub, Arlene (May 14, 2015).
299:Allen Developing Mouse Brain Atlas
14:
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1426:Allen Institute for Brain Science
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980:Doughton, Sandi (July 13, 2016).
694:"Gene Search :: Spinal Cord"
606:. August 11, 2014. Archived from
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162:Allen Institute for Brain Science
22:Allen Institute for Brain Science
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521:Davidson, Erik (July 21, 2010).
210:Allen Institute for Cell Science
1379:Vulcan Sports and Entertainment
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722:. July 17, 2008. Archived from
1551:Research institutes in Seattle
1367:Scaled Composites Stratolaunch
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191:co-founder and philanthropist
1:
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463:American Academy of Neurology
439:National Institutes of Health
272:-wide map showing where each
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1264:Orbital Sciences Pegasus II
696:. Mousespinal.brain-map.org
329:diffusion tensor technology
44:; 21 years ago
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325:magnetic resonance imaging
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1276:Mojave Aerospace Ventures
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1094:. Health. March 28, 2009.
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1512:47.650114°N 122.352457°W
491:Society for Neuroscience
839:The Wall Street Journal
399:Allen Brain Observatory
362:on September 19, 2012.
353:The Wall Street Journal
339:data derived from both
318:Allen Human Brain Atlas
256:Allen Spinal Cord Atlas
244:Allen Mouse Brain Atlas
224:Online public resources
129:Hongkui Zeng (director)
1517:47.650114; -122.352457
1397:Portland Trail Blazers
1299:Ansari X-Prize flights
1219:Living Computer Museum
422:Other online resources
416:Hubble Space Telescope
282:neurological disorders
1441:Great Elephant Census
1254:Scaled Composites Roc
1242:The Spaceship Company
1209:Museum of Pop Culture
682:. September 26, 2006.
164:is a division of the
1362:Stratolaunch Systems
1249:Stratolaunch Systems
726:on February 27, 2014
1508: /
1392:Seattle Sounders FC
1259:SpaceX Falcon 9 Air
878:10.1038/nature11405
870:2012Natur.489..391H
654:on January 15, 2015
610:on August 11, 2014.
577:. December 12, 2018
404:to a clip from the
204:History and funding
174:bioscience research
170:Seattle, Washington
107:Seattle, Washington
23:
1184:Vulcan Real Estate
1174:Vulcan Productions
604:alleninstitute.org
530:alleninstitute.org
380:neural connections
331:(DTI), as well as
172:, that focuses on
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1169:The Hospital Club
986:The Seattle Times
864:(7416): 391–399.
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