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in 1928 and Ph.D. in
Physiological Chemistry from Yale in 1931 for a dissertation entitled "Chemical and Physiological Investigations on Canine Gastric Secretion." He then joined of the Department of Pharmacology at the Yale School of Medicine as a postdoctoral fellow, where he and Louis S. Goodman,
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whose lymphosarcoma had not responded to radiation therapy. Although the intravenous nitrogen mustard regimen caused the tumor to completely recede, it regenerated within a month, and the patient died several months later. A larger clinical trial followed, and a paper was released after the studies
184:
273:, to Joseph Gilman and Rebecca Ives Gilman. Joseph Gilman owned a music store in Bridgeport, and his son learned to play several musical instruments. Unlike his father, however, Alfred Gilman turned to science, receiving a bachelor's degree from
278:
a young M.D., became colleagues and close friends. In 1934, a year before joining the Yale faculty as an assistant professor, he married Mabel
Schmidt. Their daughter, Joanna, was born in 1938, and their son,
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While teaching together, Goodman and Gilman perceived a need for an updated textbook in pharmacology that reflected advances in medicine and clarified the linkages between
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282:, in 1941. The younger Alfred Gilman, whose middle name was taken from Louis Goodman, followed his father into pharmacology and was awarded the 1994
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and kidney function. Gilman returned to Yale in 1973, where he remained as a lecturer until his death. He died at home in New Haven in 1984.
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discovered by Edward and Helen
Krumbhaar during World War I, Gilman and Goodman conducted trials on mice to research on the compounds'
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Shortly after publishing the first edition of his textbook, Gilman became section chief of pharmacology at the US Army's
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332:. In August 1942, only a few months after their initial experiments, they began trials on a patient of thoracic surgeon
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17:
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were declassified in 1946. Gilman and
Goodman are credited with the first use of intravenous chemotherapy treatment.
305:, and Gilman remained a senior editor for its first six editions. The seventh was released shortly after his death.
573:
Fenn JE; Udelsman R (March 2011). "First Use of
Intravenous Chemotherapy Cancer Treatment: Rectifying the Record".
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312:. Still affiliated with Yale, where Dean Milton C. Winternitz had recently signed a government contract with the
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in 1941, and Gilman served as an editor for its first six editions. Gilman served on the faculties of the
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in 1964 and chaired its Drug
Efficacy Review Committee. He received an honorary doctorate from
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to investigate agents of chemical warfare, Gilman and
Goodman were assigned a study of
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534:"The birth of chemotherapy at Yale. Bicentennial lecture series: Surgery Grand Round"
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After leaving his Army post in 1946, Gilman joined the faculty of
Columbia's
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297:. With assistance from Mabel, the text was first published in 1941 by the
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73:
348:, then became the chairman of the new Department of Pharmacology at the
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Chairman of
Pharmacology and Dean of the UT Southwestern Medical School
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Chemical and
Physiological Investigations on Canine Gastric Secretion
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Members of the United States National Academy of Sciences
621:"Dr. Alfred Gilman Dies at 75; Authority on Pharmacology"
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in 1956. During this period, Gilman shifted his focus to
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223:(February 5, 1908 – January 13, 1984) was an American
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For his son, a pharmacologist and Nobel laureate, see
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695:The Emperor of All Maladies: A Biography of Cancer
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320:. Interested in bone marrow depletion effects of
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239:. The pair also published the classic textbook
314:Office of Scientific Research and Development
789:Albert Einstein College of Medicine faculty
647:"Alfred Gilman, 75, expert on pharmacology"
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251:Columbia College of Physicians and Surgeons
177:Columbia College of Physicians and Surgeons
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47:
688:
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303:The Pharmacological Basis of Therapeutics
242:The Pharmacological Basis of Therapeutics
116:The Pharmacological Basis of Therapeutics
538:The Yale Journal of Biology and Medicine
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719:A Biographical Memoir of Albert Gilman
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284:Nobel Prize in Medicine and Physiology
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269:Gilman was born February 5, 1908, in
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759:People from Bridgeport, Connecticut
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350:Albert Einstein College of Medicine
255:Albert Einstein College of Medicine
181:Albert Einstein College of Medicine
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342:College of Physicians and Surgeons
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25:
805:
587:10.1016/j.jamcollsurg.2010.10.018
411:"Alfred G. Gilman – Biographical"
227:best known for pioneering early
769:Yale School of Medicine faculty
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504:Schiff, Judith Ann (May 2011).
794:20th-century American chemists
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382:History of cancer chemotherapy
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1:
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146:National Academy of Sciences
366:National Academy of Sciences
299:Macmillan Publishing Company
259:National Academy of Sciences
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784:Columbia University faculty
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113:Experimental chemotherapy;
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725:. National Academies Press
506:"Pioneers in chemotherapy"
409:Gilman, Alfred G. (1994).
364:Gilman was elected to the
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271:Bridgeport, Connecticut
247:Yale School of Medicine
173:Yale School of Medicine
27:American pharmacologist
532:Christakis, P (2011).
346:White Plains, New York
92:New Haven, Connecticut
690:Mukherjee, Siddhartha
280:Alfred Goodman Gilman
511:Yale Alumni Magazine
235:with his colleague,
764:Yale College alumni
610:, pp. 63, 68.
464:, pp. 63, 71.
221:Alfred Zack Gilman
18:Alfred Gilman, Sr.
653:. 16 January 1984
627:. 14 January 1984
370:Dartmouth College
360:Awards and honors
330:white blood cells
231:techniques using
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210:George R. Cowgill
207:Academic advisors
155:Scientific career
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16:(Redirected from
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318:nitrogen mustard
310:Edgewood Arsenal
291:pharmacodynamics
237:Louis S. Goodman
233:nitrogen mustard
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137:Alfred G. Gilman
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84:January 13, 1984
66:February 5, 1908
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328:properties for
295:pharmacotherapy
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265:Life and career
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103:Yale University
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110:Known for
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88:(aged 75)
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105:(B.S., Ph.D.)
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727:. Retrieved
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698:. Scribner.
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682:Bibliography
672:Ritchie 1996
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655:. Retrieved
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629:. Retrieved
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608:Ritchie 1996
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515:. Retrieved
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418:. Retrieved
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275:Yale College
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229:chemotherapy
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169:Institutions
164:Pharmacology
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86:(1984-01-13)
754:1984 deaths
749:1908 births
322:mustard gas
74:Connecticut
743:Categories
388:References
253:, and the
70:Bridgeport
62:1908-02-05
372:in 1979.
354:diuretics
326:cytotoxic
729:26 March
716:(1996).
692:(2010).
657:26 March
631:26 March
595:21247779
560:21698052
517:26 March
420:25 March
376:See also
131:Children
551:3117414
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249:, the
201:(1934)
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192:Thesis
161:Fields
148:(1964)
143:Awards
123:Spouse
723:(PDF)
393:Notes
731:2015
700:ISBN
659:2015
633:2015
591:PMID
556:PMID
519:2015
422:2015
293:and
81:Died
56:Born
583:doi
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546:PMC
301:as
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