111:
Acute uric acid nephropathy is caused by deposition of uric acid crystals within the kidney interstitium and tubules, leading to partial or complete obstruction of collecting ducts, renal pelvis, or ureter. This obstruction is usually bilateral, and patients follow the clinical course of
128:
levels. Acute uric acid nephropathy is differentiated from other forms of acute kidney failure by the finding of a urine uric acid/creatinine ratio > 1 in a random urine sample.
238:
Yu AS, Brenner BM (2005). "Chapter 266: Tubulointerstitial diseases of the kidney". In Kasper DL, Braunwald E, Fauci A, Hauser S, Longo D, Jameson JL (eds.).
156:
Treatment is focused on preventing deposition of uric acid within the urinary system by increasing urine volume with potent diuretics such as
248:
84:
in patients undergoing chemotherapy or radiation therapy for the treatment of malignancies with rapid cell turnover, such as
92:. It may also occur in these patients before treatment is begun, due to spontaneous tumor cell lysis (high incidence in
160:. Raising the urinary pH to a level higher than 7 (alkalinization) is often difficult to attain, although
124:
The picture of acute kidney failure is observed: decreased urine production and rapidly rising serum
93:
81:
113:
8:
263:
57:
161:
244:
226:
197:
30:
218:
171:
69:
222:
257:
165:
145:
175:
201:
230:
141:
137:
157:
125:
16:
Decreasing kidney function due to high levels of uric acid in the urine
99:
Acute uric acid nephropathy can also be caused by an acute attack of
61:
168:
are sometimes used in an attempt to increase uric acid solubility.
89:
85:
80:
Acute uric acid nephropathy is usually seen as part of the acute
53:
209:
Robinson RR, Yarger WE (1977). "Acute uric acid nephropathy".
136:
Patients at risk for acute uric acid nephropathy can be given
65:
100:
242:(16th ed.). New York: McGraw-Hill Professional.
188:Conger JD (1990). "Acute uric acid nephropathy".
255:
208:
148:) prior to treatment with cytotoxic drugs.
240:Harrison's Principles of Internal Medicine
237:
187:
178:) is started if the above measures fail.
256:
52:) is a rapidly worsening (decreasing)
60:) that is caused by high levels of
13:
106:
14:
275:
1:
181:
131:
151:
119:
7:
42:Acute uric acid nephropathy
25:Acute uric acid nephropathy
10:
280:
223:10.1001/archinte.137.7.839
75:
29:
24:
50:acute urate nephropathy
82:tumour lysis syndrome
114:acute kidney failure
58:acute kidney injury
162:sodium bicarbonate
94:Burkitt's lymphoma
249:978-0-07-140235-4
190:Med Clin North Am
39:
38:
19:Medical condition
271:
243:
234:
205:
22:
21:
279:
278:
274:
273:
272:
270:
269:
268:
254:
253:
211:Arch Intern Med
184:
154:
144:(a recombinant
134:
122:
109:
107:Pathophysiology
78:
70:hyperuricosuria
20:
17:
12:
11:
5:
277:
267:
266:
252:
251:
235:
206:
183:
180:
153:
150:
133:
130:
121:
118:
108:
105:
77:
74:
37:
36:
33:
27:
26:
18:
15:
9:
6:
4:
3:
2:
276:
265:
262:
261:
259:
250:
246:
241:
236:
232:
228:
224:
220:
217:(7): 839–40.
216:
212:
207:
203:
199:
196:(4): 859–71.
195:
191:
186:
185:
179:
177:
173:
169:
167:
166:acetazolamide
163:
159:
149:
147:
146:urate oxidase
143:
139:
129:
127:
117:
115:
104:
102:
97:
95:
91:
87:
83:
73:
71:
67:
63:
59:
55:
51:
47:
43:
34:
32:
28:
23:
239:
214:
210:
193:
189:
176:hemodialysis
174:(preferably
170:
155:
135:
123:
110:
98:
79:
49:
45:
41:
40:
142:rasburicase
138:allopurinol
264:Nephrology
182:References
158:furosemide
132:Prevention
126:creatinine
56:function (
35:Nephrology
152:Treatment
120:Diagnosis
62:uric acid
31:Specialty
258:Category
172:Dialysis
90:lymphoma
86:leukemia
202:2195258
164:and/or
64:in the
48:, also
247:
231:879920
229:
200:
76:Causes
54:kidney
66:urine
245:ISBN
227:PMID
198:PMID
101:gout
88:and
46:AUAN
219:doi
215:137
140:or
96:).
72:).
260::
225:.
213:.
194:74
192:.
116:.
103:.
233:.
221::
204:.
68:(
44:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.