732:
distribution of rasburicase ranged from 110 to 127 mL/kg in pediatric patients and from 75.8 to 138 mL/kg in adult patients, respectively. Minimal accumulation of rasburicase ( < 1.3 fold) was observed between days 1 and 5 of dosing. In adults, age, gender, baseline liver enzymes and creatinine clearance did not impact the pharmacokinetics of rasburicase. A cross-study comparison revealed that after administration of rasburicase at 0.15 or 0.20 mg/kg, the geometric mean values of body-weight normalized clearance were approximately 40% lower in
Japanese (n=20) than that in Caucasians (n=22).
428:
1402:
31:
591:. The drug product is a sterile, white to off-white, lyophilized powder intended for intravenous administration following reconstitution with a diluent. Elitek (rasburicase) is supplied in 3 mL and 10 mL colorless, glass vials containing rasburicase at a concentration of 1.5 mg/mL after reconstitution.
714:
The measurement of plasma uric acid was used to evaluate the effectiveness of rasburicase in clinical studies. Following administration of either 0.15 or 0.20 mg/kg rasburicase daily for up to 5 days, plasma uric acid levels decreased within 4 hours and were maintained below 7.5 mg/dL in
731:
or other hematological malignancies. Rasburicase exposure, as measured by AUC0-24 hr and Cmax, tended to increase with a dose range from 0.15 to 0.2 mg/kg. The mean terminal half-life was similar between pediatric and adult patients and ranged from 15.7 to 22.5 hours. The mean volume of
1051:
Lin PY, Lin CC, Liu HC, Lee MD, Lee HC, Ho CS, et al. (November 2011). "Rasburicase improves hyperuricemia in patients with acute kidney injury secondary to rhabdomyolysis caused by ecstasy intoxication and exertional heat stroke".
1203:
715:
98% of adult and 90% of pediatric patients for at least 7 days. There was no evidence of a dose response effect on uric acid control for doses between 0.15 and 0.20 mg/kg rasburicase.
918:
Ho VQ, Wetzstein GA, Patterson SG, Bradbury R (April 2006). "Abbreviated rasburicase dosing for the prevention and treatment of hyperuricemia in adults at risk for tumor lysis syndrome".
698:
is the final step in the catabolic pathway of purines. Rasburicase catalyzes enzymatic oxidation of poorly soluble uric acid into an inactive and more soluble metabolite allantoin with
186:
681:
due to the production of hydrogen peroxide in the urate oxidase reaction. Testing patients for G6PDH deficiency prior to starting a course of rasburicase has been recommended.
1196:
1189:
1427:
141:
498:
746:
619:
554:. Urate oxidase is known to be present in many mammals but does not naturally occur in humans. Rasburicase is produced by a genetically modified
53:
678:
607:
630:. However, it is not clear if it results in important benefits such as decreased kidney problems or decreased risk of death as of 2017.
1095:
595:
1422:
505:
90:
263:
171:
71:
309:
423:
356:
405:
767:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
1181:
1392:
1345:
890:
766:
556:
955:"Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer"
127:
43:
876:
795:
1089:
723:
The pharmacokinetics of rasburicase were evaluated in both pediatric and adult patients with
300:
289:
1264:
1138:"A costly therapeutic dilemma in tophaceous gout: is etanercept or rasburicase preferable?"
611:
365:
242:
134:
745:
Rasburicase is much more expensive than the conventional uric acid lowering treatment for
8:
1004:"Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout"
427:
280:
1162:
1137:
1077:
1028:
1003:
979:
954:
580:
566:
101:
1167:
1118:
1069:
1033:
984:
935:
853:
703:
674:
561:
1081:
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1023:
1015:
974:
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927:
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224:
154:
63:
1406:
1369:
1220:
1153:
1065:
539:
232:
1110:
1212:
699:
650:
646:
1416:
1309:
895:
World Health
Organization model list of essential medicines: 22nd list (2021)
642:
634:
543:
416:
199:
22:
1374:
1242:
1233:
1216:
1171:
1122:
1073:
1037:
988:
939:
931:
857:
615:
149:
1379:
1317:
1211:
848:
831:
670:
575:
903:
661:
Rasburicase use is contraindicated in patients with a G6PDH deficiency.
329:
1353:
1335:
1327:
1229:
637:
from other sources. For example, it has been used for hyperuricemia in
588:
584:
527:
479:
340:
1019:
1260:
695:
551:
531:
57:
1283:
728:
724:
627:
623:
385:
320:
85:
583:
with identical subunits. Each subunit is made up of a single 301
610:(and European counterparts) for the prevention and treatment of
1136:
Reinders MK, van Roon EN, Brouwers JR, Jansen TL (March 2005).
547:
396:
1135:
30:
1295:
535:
917:
1305:
1113:. In Pratt VM, Scott SA, Pirmohamed M, et al. (eds.).
638:
376:
564:(cDNA) coding for rasburicase was cloned from a strain of
889:
774:
677:
may occur in susceptible individuals such as those with
596:
1117:. National Center for Biotechnology Information (US).
1001:
836:
Clinical
Journal of the American Society of Nephrology
1390:
871:
869:
867:
587:
polypeptide chain with a molecular mass of about 34
759:
308:
953:Cheuk DK, Chiang AK, Chan GC, Ha SY (March 2017).
1111:"Rasburicase Therapy and G6PD and CYB5R Genotype"
952:
864:
1414:
633:It is being investigated for treating severely
288:
1428:World Health Organization essential medicines
1197:
1129:
1050:
1044:
825:
823:
821:
819:
817:
89:
1002:Cammalleri L, Malaguarnera M (March 2007).
995:
959:The Cochrane Database of Systematic Reviews
911:
829:
216:In general: ℞ (Prescription only)
1204:
1190:
426:
1161:
1027:
1008:International Journal of Medical Sciences
978:
902:
847:
814:
364:
1108:
706:as byproducts in the chemical reaction.
832:"Onco-nephrology: tumor lysis syndrome"
606:Rasburicase is approved for use by the
328:
1415:
883:
735:
689:
417:
208:
1247:calcium folinate/calcium levofolinate
1185:
897:. Geneva: World Health Organization.
669:Rasburicase administration can cause
404:
193:
80:
62:
1109:Dean L, Kane M (29 September 2020).
830:Wilson FP, Berns JS (October 2012).
153:
1250:sodium folinate/sodium levofolinate
718:
709:
656:
384:
13:
1094:: CS1 maint: overridden setting (
14:
1439:
608:U.S. Food and Drug Administration
180:
112:
1400:
1142:Annals of the Rheumatic Diseases
1054:Pediatric Critical Care Medicine
457:
451:
29:
1102:
800:European Medicines Agency (EMA)
684:
664:
601:
971:10.1002/14651858.CD006945.pub4
946:
788:
635:high blood levels of uric acid
550:that metabolizes uric acid to
469:
463:
445:
1:
752:
1154:10.1136/ard.2003.017087corr1
1148:(3): 516, author reply 516.
1066:10.1097/PCC.0b013e3182192c8d
740:
518:, sold under the brand name
7:
10:
1444:
1423:Chemotherapeutic adjuvants
1346:Keratinocyte growth factor
1115:Medical Genetics Summaries
907:. WHO/MHP/HPS/EML/2021.02.
614:(TLS) in people receiving
435:Chemical and physical data
1362:
1344:
1326:
1304:
1282:
1259:
1228:
920:Supportive Cancer Therapy
891:World Health Organization
495:
478:
439:
434:
415:
395:
375:
355:
339:
319:
299:
279:
271:Aspergillus urate oxidase
259:
254:
241:
231:
223:
170:
165:
140:
126:
100:
70:
52:
42:
37:
28:
557:Saccharomyces cerevisiae
932:10.3816/SCT.2006.n.016
877:"Elitek (rasburicase)"
673:(incidence unknown);
849:10.2215/CJN.03150312
612:tumor lysis syndrome
530:that helps to clear
135:Intravenous infusion
736:Society and culture
690:Mechanism of Action
645:conditions, and in
620:hematologic cancers
189:(Prescription only)
25:
16:Pharmaceutical drug
802:. 23 February 2001
581:tetrameric protein
567:Aspergillus flavus
21:
1388:
1387:
1328:Alkylating agents
1288:nitrogen mustards
1020:10.7150/ijms.4.83
842:(10): 1730–1739.
704:hydrogen peroxide
675:methemoglobinemia
562:complementary DNA
513:
512:
212:
197:
184:
116:
83:
48:Elitek, Fasturtec
1435:
1405:
1404:
1403:
1396:
1206:
1199:
1192:
1183:
1182:
1176:
1175:
1165:
1133:
1127:
1126:
1106:
1100:
1099:
1093:
1085:
1060:(6): e424–e427.
1048:
1042:
1041:
1031:
999:
993:
992:
982:
950:
944:
943:
915:
909:
908:
906:
887:
881:
880:
873:
862:
861:
851:
827:
812:
811:
809:
807:
796:"Fasturtec EPAR"
792:
786:
785:
783:
781:
771:nctr-crs.fda.gov
763:
719:Pharmacokinetics
710:Pharmacodynamics
679:G6PDH deficiency
657:Contraindication
578:
526:in the EU, is a
509:
508:
501:
490:
488:
471:
465:
459:
453:
447:
430:
419:
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368:
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114:
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93:
82:
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66:
33:
26:
24:
20:
1443:
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1434:
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1413:
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1411:
1401:
1399:
1391:
1389:
1384:
1370:Arginine/lysine
1358:
1340:
1322:
1300:
1278:
1255:
1224:
1210:
1180:
1179:
1134:
1130:
1107:
1103:
1087:
1086:
1049:
1045:
1000:
996:
965:(3): CD006945.
951:
947:
916:
912:
888:
884:
875:
874:
865:
828:
815:
805:
803:
794:
793:
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747:tophaceous gout
743:
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692:
687:
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659:
604:
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504:
502:
499:(what is this?)
496:
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371:
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233:Bioavailability
225:Pharmacokinetic
219:
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96:
17:
12:
11:
5:
1441:
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1310:anthracyclines
1302:
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994:
945:
926:(3): 178–182.
910:
882:
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813:
787:
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742:
739:
737:
734:
720:
717:
711:
708:
700:carbon dioxide
691:
688:
686:
683:
666:
663:
658:
655:
651:kidney failure
647:rhabdomyolysis
603:
600:
522:in the US and
511:
510:
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15:
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1021:
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1005:
998:
990:
986:
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968:
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956:
949:
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921:
914:
905:
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886:
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872:
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868:
859:
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845:
841:
837:
833:
826:
824:
822:
820:
818:
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797:
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772:
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762:
758:
750:
748:
733:
730:
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716:
707:
705:
701:
697:
682:
680:
676:
672:
662:
654:
652:
648:
644:
643:rheumatologic
640:
636:
631:
629:
625:
621:
617:
613:
609:
599:
597:
594:It is on the
592:
590:
586:
582:
577:
573:Rasburicase (
571:
569:
568:
563:
559:
558:
553:
549:
545:
544:urate oxidase
541:
537:
533:
529:
525:
521:
517:
507:
500:
494:
483:
481:
477:
444:
442:
438:
433:
429:
425:
422:
420:
418:ECHA InfoCard
414:
407:
406:ChEMBL1201594
403:
402:
400:
398:
394:
387:
383:
382:
380:
378:
374:
367:
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362:
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278:
269:
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265:
258:
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230:
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222:
215:
213: Rx-only
206:
203:
191:
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156:
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145:
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125:
119:
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109:
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105:
99:
92:
87:
78:
77:
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69:
65:
61:
59:
55:
51:
47:
45:
41:
38:Clinical data
36:
32:
27:
19:
1375:Glucarpidase
1273:
1243:Folinic acid
1234:methotrexate
1217:chemotherapy
1145:
1141:
1131:
1114:
1104:
1090:cite journal
1057:
1053:
1046:
1014:(2): 83–93.
1011:
1007:
997:
962:
958:
948:
923:
919:
913:
904:10665/345533
894:
885:
839:
835:
804:. Retrieved
799:
790:
778:. Retrieved
770:
761:
744:
722:
713:
693:
685:Pharmacology
668:
665:Side effects
660:
632:
616:chemotherapy
605:
602:Medical uses
593:
572:
565:
560:strain. The
555:
523:
519:
515:
514:
503:
497:
243:Elimination
172:Legal status
166:Legal status
72:License data
18:
1380:Trilaciclib
1318:Dexrazoxane
1274:Rasburicase
1219:treatment (
1215:agents for
1213:Detoxifying
694:In humans,
671:anaphylaxis
641:, in other
542:version of
540:recombinant
516:Rasburicase
491: g·mol
424:100.207.686
290:134774-45-1
255:Identifiers
91:Rasburicase
44:Trade names
23:Rasburicase
1417:Categories
1354:Palifermin
1336:Amifostine
1230:Folic acid
780:22 October
753:References
585:amino acid
538:. It is a
528:medication
480:Molar mass
366:08GY9K1EUO
341:ChemSpider
301:IUPHAR/BPS
281:CAS Number
264:IUPAC name
1261:Uric acid
1241:Salts of
879:. Rxlist.
806:14 August
741:Economics
696:uric acid
628:lymphomas
624:leukemias
552:allantoin
534:from the
532:uric acid
524:Fasturtec
245:half-life
128:Routes of
102:Pregnancy
64:Monograph
58:Drugs.com
1407:Medicine
1284:Acrolein
1172:15708917
1123:32997466
1082:23910863
1074:21572370
1038:17396159
989:28272834
940:18632493
893:(2021).
858:22879434
729:lymphoma
725:leukemia
622:such as
506:(verify)
321:DrugBank
142:ATC code
117: B2
104:category
86:DailyMed
1163:1755382
1029:1838823
980:6464610
579:) is a
441:Formula
330:DB00049
204:Rx-only
201:WARNING
158:)
152: (
150:V03AF07
88::
1393:Portal
1170:
1160:
1121:
1080:
1072:
1036:
1026:
987:
977:
938:
856:
576:Q00511
548:enzyme
520:Elitek
397:ChEMBL
386:D05704
250:18 hrs
198:
185:
84:
1363:Other
1296:Mesna
1221:V03AF
1078:S2CID
649:with
546:, an
536:blood
1306:Iron
1168:PMID
1119:PMID
1096:link
1070:PMID
1034:PMID
985:PMID
963:2017
936:PMID
854:PMID
808:2024
782:2023
702:and
639:gout
626:and
618:for
455:2381
449:1521
377:KEGG
357:UNII
348:none
310:7467
227:data
54:AHFS
1265:TLS
1158:PMC
1150:doi
1062:doi
1024:PMC
1016:doi
975:PMC
967:doi
928:doi
899:hdl
844:doi
775:FDA
589:kDa
489:.66
487:109
467:461
461:417
237:N/A
155:WHO
1419::
1308:/
1286:/
1232:/
1166:.
1156:.
1146:64
1144:.
1140:.
1092:}}
1088:{{
1076:.
1068:.
1058:12
1056:.
1032:.
1022:.
1010:.
1006:.
983:.
973:.
961:.
957:.
934:.
922:.
866:^
852:.
838:.
834:.
816:^
798:.
773:.
769:.
749:.
727:,
653:.
598:.
570:.
485:34
209:EU
194:US
187:S4
181:AU
113:AU
81:US
1395::
1267:)
1263:(
1223:)
1205:e
1198:t
1191:v
1174:.
1152::
1125:.
1098:)
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