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Paltusotine

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717: 25: 197: 66: 120: 588:
Gadelha, Monica R; Gordon, Murray B; Doknic, Mirjana; Mezősi, Emese; Tóth, Miklós; Randeva, Harpal; Marmon, Tonya; Jochelson, Theresa; Luo, Rosa; Monahan, Michael; Madan, Ajay; Ferrara-Cook, Christine; Struthers, R Scott; Krasner, Alan (13 April 2023).
538:
Zhao, Jian; Wang, Shimiao; Markison, Stacy; Kim, Sun Hee; Han, Sangdon; Chen, Mi; Kusnetzow, Ana Karin; Rico-Bautista, Elizabeth; Johns, Michael; Luo, Rosa; Struthers, R. Scott; Madan, Ajay; Zhu, Yunfei; Betz, Stephen F. (12 January 2023).
90: 648:
Zhao, Jie; Fu, Hong; Yu, Jingjing; Hong, Weiqi; Tian, Xiaowen; Qi, Jieyu; Sun, Suyue; Zhao, Chang; Wu, Chao; Xu, Zheng; Cheng, Lin; Chai, Renjie; Yan, Wei; Wei, Xiawei; Shao, Zhenhua (21 February 2023).
400: 442:
InChI=1S/C27H22F2N4O/c28-19-10-18(11-20(29)13-19)24-15-32-25-5-4-16(22-3-1-2-17(14-30)27(22)34)12-23(25)26(24)33-8-6-21(31)7-9-33/h1-5,10-13,15,21,34H,6-9,31H2
138: 489:
Madan, Ajay; Markison, Stacy; Betz, Stephen F.; Krasner, Alan; Luo, Rosa; Jochelson, Theresa; Lickliter, Jason; Struthers, R. Scott (April 2022).
414: 758: 491:"Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers" 80: 434: 174: 156: 52: 233: 209: 591:"ACROBAT Edge: Safety and Efficacy of Switching Injected SRLs to Oral Paltusotine in Patients With Acromegaly" 541:"Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist" 315: 38: 807: 751: 651:"Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine" 782: 304: 802: 461: 259: 792: 744: 662: 324: 8: 777: 250: 666: 617: 590: 691: 650: 630: 565: 540: 515: 490: 284: 732: 696: 678: 634: 622: 570: 520: 134: 787: 686: 670: 612: 602: 560: 556: 552: 510: 502: 340: 76: 44: 95: 797: 728: 674: 506: 469: 771: 682: 607: 188: 724: 700: 626: 574: 524: 465: 376: 295: 270: 85: 129:
provides insufficient context for those unfamiliar with the subject
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C1CN(CCC1N)C2=C3C=C(C=CC3=NC=C2C4=CC(=CC(=C4)F)F)C5=CC=CC(=C5O)C#N
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type 2 (SST2) agonist in development for the treatment of
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The Journal of Clinical Endocrinology & Metabolism
537: 769: 283: 258: 752: 647: 468:and certain neuroendocrine tumors. It is a 53:Learn how and when to remove these messages 759: 745: 303: 195: 690: 616: 606: 564: 514: 323: 175:Learn how and when to remove this message 157:Learn how and when to remove this message 770: 139:providing more context for the reader 711: 113: 59: 18: 274: 13: 14: 819: 34:This article has multiple issues. 715: 363: 357: 351: 118: 64: 23: 545:ACS Medicinal Chemistry Letters 447:Key:GHILNKWBALQPDP-UHFFFAOYSA-N 42:or discuss these issues on the 641: 581: 557:10.1021/acsmedchemlett.2c00431 531: 482: 369: 345: 1: 475: 731:. You can help Knowledge by 7: 10: 824: 710: 675:10.1038/s41467-023-36673-z 507:10.1007/s11102-021-01201-z 335:Chemical and physical data 430: 410: 388: 375: 339: 334: 314: 294: 269: 249: 229: 224: 208: 203: 194: 241:3--2-hydroxybenzonitrile 79:, as no other articles 727:-related article is a 608:10.1210/clinem/dgac643 655:Nature Communications 462:somatostatin receptor 667:2023NatCo..14..962Z 191: 135:improve the article 808:Pharmacology stubs 472:delivered orally. 187: 98:for suggestions. 88:to this page from 740: 739: 455: 454: 401:Interactive image 185: 184: 177: 167: 166: 159: 112: 111: 57: 16:Chemical compound 815: 761: 754: 747: 719: 712: 705: 704: 694: 645: 639: 638: 620: 610: 601:(5): e148–e159. 585: 579: 578: 568: 535: 529: 528: 518: 486: 403: 383: 371: 365: 359: 353: 347: 327: 307: 287: 277: 276: 262: 199: 192: 190: 186: 180: 173: 162: 155: 151: 148: 142: 122: 121: 114: 107: 104: 93: 91:related articles 68: 60: 49: 27: 26: 19: 823: 822: 818: 817: 816: 814: 813: 812: 768: 767: 766: 765: 709: 708: 646: 642: 586: 582: 536: 532: 487: 483: 478: 460:is a selective 451: 448: 443: 438: 437: 426: 423: 418: 417: 406: 381: 368: 362: 356: 350: 330: 310: 290: 273: 265: 245: 242: 237: 236: 220: 217:Investigational 181: 170: 169: 168: 163: 152: 146: 143: 132: 123: 119: 108: 102: 99: 89: 86:introduce links 69: 28: 24: 17: 12: 11: 5: 821: 811: 810: 805: 800: 795: 790: 785: 780: 764: 763: 756: 749: 741: 738: 737: 720: 707: 706: 640: 580: 530: 501:(2): 328–339. 480: 479: 477: 474: 470:small molecule 453: 452: 450: 449: 446: 444: 441: 433: 432: 431: 428: 427: 425: 424: 421: 413: 412: 411: 408: 407: 405: 404: 396: 394: 386: 385: 379: 373: 372: 366: 360: 354: 348: 343: 337: 336: 332: 331: 329: 328: 320: 318: 312: 311: 309: 308: 300: 298: 292: 291: 289: 288: 280: 278: 267: 266: 264: 263: 255: 253: 247: 246: 244: 243: 240: 232: 231: 230: 227: 226: 222: 221: 219: 218: 214: 212: 206: 205: 201: 200: 183: 182: 165: 164: 126: 124: 117: 110: 109: 96:Find link tool 72: 70: 63: 58: 32: 31: 29: 22: 15: 9: 6: 4: 3: 2: 820: 809: 806: 804: 801: 799: 796: 794: 791: 789: 786: 784: 783:Benzonitriles 781: 779: 776: 775: 773: 762: 757: 755: 750: 748: 743: 742: 736: 734: 730: 726: 721: 718: 714: 713: 702: 698: 693: 688: 684: 680: 676: 672: 668: 664: 660: 656: 652: 644: 636: 632: 628: 624: 619: 614: 609: 604: 600: 596: 592: 584: 576: 572: 567: 562: 558: 554: 550: 546: 542: 534: 526: 522: 517: 512: 508: 504: 500: 496: 492: 485: 481: 473: 471: 467: 463: 459: 445: 440: 439: 436: 429: 420: 419: 416: 409: 402: 398: 397: 395: 392: 387: 380: 378: 374: 344: 342: 338: 333: 326: 322: 321: 319: 317: 313: 306: 302: 301: 299: 297: 293: 286: 282: 281: 279: 272: 268: 261: 257: 256: 254: 252: 248: 239: 238: 235: 228: 223: 216: 215: 213: 211: 207: 202: 198: 193: 179: 176: 161: 158: 150: 147:November 2023 140: 136: 130: 127:This article 125: 116: 115: 106: 103:November 2023 97: 92: 87: 83: 82: 78: 73:This article 71: 67: 62: 61: 56: 54: 47: 46: 41: 40: 35: 30: 21: 20: 803:Fluoroarenes 733:expanding it 725:pharmacology 722: 658: 654: 643: 598: 594: 583: 551:(1): 66–74. 548: 544: 533: 498: 494: 484: 457: 456: 260:2172870-89-0 210:Legal status 204:Legal status 171: 153: 144: 133:Please help 128: 100: 74: 50: 43: 37: 36:Please help 33: 793:Piperidines 458:Paltusotine 384: g·mol 225:Identifiers 189:Paltusotine 778:Quinolines 772:Categories 661:(1): 962. 476:References 466:acromegaly 389:3D model ( 377:Molar mass 325:F2IBD1GMD3 296:ChemSpider 251:CAS Number 234:IUPAC name 94:; try the 81:link to it 39:improve it 683:2041-1723 635:253445337 495:Pituitary 285:134168328 84:. Please 45:talk page 701:36810324 627:36353760 618:10099171 575:36655128 525:35000098 305:81367268 788:Phenols 692:9944328 663:Bibcode 566:9841592 516:8894159 382:456.497 341:Formula 271:PubChem 798:Amines 699:  689:  681:  633:  625:  615:  573:  563:  523:  513:  415:SMILES 77:orphan 75:is an 723:This 631:S2CID 435:InChI 391:JSmol 729:stub 697:PMID 679:ISSN 623:PMID 571:PMID 521:PMID 316:UNII 687:PMC 671:doi 613:PMC 603:doi 599:108 561:PMC 553:doi 511:PMC 503:doi 275:CID 137:by 774:: 695:. 685:. 677:. 669:. 659:14 657:. 653:. 629:. 621:. 611:. 597:. 593:. 569:. 559:. 549:14 547:. 543:. 519:. 509:. 499:25 497:. 493:. 355:22 349:27 48:. 760:e 753:t 746:v 735:. 703:. 673:: 665:: 637:. 605:: 577:. 555:: 527:. 505:: 393:) 370:O 367:4 364:N 361:2 358:F 352:H 346:C 178:) 172:( 160:) 154:( 149:) 145:( 141:. 131:. 105:) 101:( 55:) 51:(

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Legal status
IUPAC name
CAS Number
2172870-89-0
PubChem
134168328
ChemSpider
81367268
UNII
F2IBD1GMD3
Formula
Molar mass
JSmol
Interactive image
SMILES
InChI

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