150:
proliferation and DNA repair processes, and identified novel strategies for therapeutic intervention. Notable discoveries include identification of RB tumor suppressor loss as a major mechanism of therapeutic bypass, discovery of the androgen-DNA repair axis, and elucidation of androgen receptor
89:
In 2007 she joined the Sidney Kimmel Cancer Center at
Jefferson Health, and founded the cancer center’s prostate cancer program. After serving as the Deputy Director of the Sidney Kimmel Cancer Center and the Vice Provost of Thomas Jefferson University, Knudsen accepted the offer to serve as the
1011:
762:
de Leeuw, Renée; McNair, Christopher; Schiewer, Matthew J.; Neupane, Neermala Poudel; Brand, Lucas J.; Augello, Michael A.; Li, Zhen; Cheng, Larry C.; Yoshida, Akihiro; Courtney, Sean M.; Hazard, E. Starr (September 2018).
578:
Dylgjeri, Emanuela; McNair, Christopher; Goodwin, Jonathan F.; Raymon, Heather K.; McCue, Peter A.; Shafi, Ayesha A.; Leiby, Benjamin E.; Leeuw, Renée de; Kothari, Vishal; McCann, Jennifer J.; Mandigo, Amy C. (2019-09-15).
820:
Schiewer, Matthew J.; Goodwin, Jonathan F.; Han, Sumin; Brenner, J. Chad; Augello, Michael A.; Dean, Jeffry L.; Liu, Fengzhi; Planck, Jamie L.; Ravindranathan, Preethi; Chinnaiyan, Arul M.; McCue, Peter (December 2012).
520:
Goodwin, Jonathan F.; Kothari, Vishal; Drake, Justin M.; Zhao, Shuang; Dylgjeri, Emanuela; Dean, Jeffry L.; Schiewer, Matthew J.; McNair, Christopher; Jones, Jennifer K.; Aytes, Alvaro; Magee, Michael S. (2015-07-13).
347:
Sharma, Ankur; Yeow, Wen-Shuz; Ertel, Adam; Coleman, Ilsa; Clegg, Nigel; Thangavel, Chellappagounder; Morrissey, Colm; Zhang, Xiaotun; Comstock, Clay E. S.; Witkiewicz, Agnieszka K.; Gomella, Leonard (December 2010).
462:
Goodwin, Jonathan F.; Schiewer, Matthew J.; Dean, Jeffry L.; Schrecengost, Randy S.; de Leeuw, Renée; Han, Sumin; Ma, Teng; Den, Robert B.; Dicker, Adam P.; Feng, Felix Y.; Knudsen, Karen E. (November 2013).
704:
Augello, Michael A.; Burd, Craig J.; Birbe, Ruth; McNair, Christopher; Ertel, Adam; Magee, Michael S.; Frigo, Daniel E.; Wilder-Romans, Kari; Shilkrut, Mark; Han, Sumin; Jernigan, Danielle L. (2013-01-02).
636:
Burd, Craig J.; Petre, Christin E.; Morey, Lisa M.; Wang, Ying; Revelo, Monica P.; Haiman, Christopher A.; Lu, Shan; Fenoglio-Preiser, Cecilia M.; Li, Jiwen; Knudsen, Erik S.; Wong, Jiemin (2006-02-14).
935:
Schiewer, Matthew J.; Mandigo, Amy C.; Gordon, Nicolas; Huang, Fangjin; Gaur, Sanchaika; de Leeuw, Renée; Zhao, Shuang G.; Evans, Joseph; Han, Sumin; Parsons, Theodore; Birbe, Ruth (1 December 2018).
405:
McNair, Christopher; Xu, Kexin; Mandigo, Amy C.; Benelli, Matteo; Leiby, Benjamin; Rodrigues, Daniel; Lindberg, Johan; Gronberg, Henrik; Crespo, Mateus; De Laere, Bram; Dirix, Luc (January 2018).
134:, with an emphasis on understanding therapeutic relapse and designing new means of clinical intervention. Her translational studies have resulted in new clinical trials targeting
993:
90:
Enterprise
Director of the Sidney Kimmel Cancer Center in 2015, leading the cancer care and cancer discovery mission for Jefferson Health. She is also editor-in-chief,
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290:
Sharma, Ankur; Comstock, Clay E. S.; Knudsen, Erik S.; Cao, Khanh H.; Hess-Wilson, Janet K.; Morey, Lisa M.; Barrera, Jason; Knudsen, Karen E. (2007-07-01).
1176:
98:
Dr. Knudsen currently holds leadership roles with some of the most important cancer entities in the nation. She serves on the board of advisors for the
151:
function in the mitotic cell cycle. Her discoveries were amongst the first to propose utilization of PARP 1/2 inhibitors for advanced disease, now an
24:
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50:, Pennsylvania. She also held secondary appointments in the Departments of Urology, Medical Oncology, and Radiation Oncology.
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and on 12 external advisory boards for NCI-designated cancer centers. She is an active member of several committees with the
67:
106:(ASCO), in addition to serving on other academic and for-profit advisory boards. She previously served as president of the
63:
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regulation pathways in patients with advanced disease. Knudsen and her colleagues discovered the mechanisms by which
1035:
292:"Retinoblastoma Tumor Suppressor Status Is a Critical Determinant of Therapeutic Response in Prostate Cancer Cells"
152:
110:(AACI), representing the 102 leading cancer centers in North America, and on the board of directors of the
59:
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114:(AACR). Dr. Knudsen was also recognized as one of the 100 Influential Women in Oncology by OncoDaily.
43:
350:"The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression"
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639:"Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation"
20:
523:"DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis"
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in the United States. Previously she was the Hilary
Koprowski Endowed Professor of Oncology at
994:"FDA approves olaparib for HRR gene-mutated metastatic castration-resistant prostate cancer"
650:
30:
Prior to joining ACS, Dr. Knudsen served as
Executive Vice President of Oncology Services,
273:"100 Influential Women in Oncology: Key Opinion Leaders to follow on Social Media in 2023"
8:
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707:"Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes"
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Feng, Felix Y.; de Bono, Johann S.; Rubin, Mark A.; Knudsen, Karen E. (2015-06-18).
581:"Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies"
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1012:"AACI President Knudsen to Focus Two-Year Term on Mitigating Health Disparities"
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880:"Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function"
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407:"Differential impact of RB status on E2F1 reprogramming in human cancer"
27:. She is the first woman to hold that position in either organization.
465:"A hormone-DNA repair circuit governs the response to genotoxic insult"
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765:"MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer"
223:"American Cancer Society Names Dr. Karen Knudsen as its Next CEO"
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823:"Dual roles of PARP-1 promote cancer growth and progression"
74:. She completed her postdoctoral fellowship training at the
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in 2000, wherein she became a tenured
Associate Professor.
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Knudsen received her bachelor’s degree in biology from the
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Research, Center for Drug
Evaluation and (2020-05-20).
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937:"PARP-1 regulates DNA repair factor availability"
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1040:American Association for Cancer Research (AACR)
643:Proceedings of the National Academy of Sciences
155:-approved agent for selected prostate cancers.
1172:Columbian College of Arts and Sciences alumni
1108:"Editorial Board | Molecular Cancer Research"
249:"Editorial Board | Molecular Cancer Research"
25:American Cancer Society Cancer Action Network
84:University of Cincinnati College of Medicine
1177:University of California, San Diego alumni
66:in 1996, and her MBA with honors from the
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166:Association of American Cancer Institutes
108:Association of American Cancer Institutes
36:Sidney Kimmel Comprehensive Cancer Center
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173:American Association for Cancer Research
126:researcher whose studies are focused on
112:American Association for Cancer Research
62:, her PhD in molecular biology from the
53:
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1084:"Genentech: Scientific Research Board"
104:American Society for Clinical Oncology
711:The Journal of Clinical Investigation
411:The Journal of Clinical Investigation
354:The Journal of Clinical Investigation
68:Fox School of Business and Management
64:University of California at San Diego
1036:"Board of Directors | AACR About Us"
78:, San Diego under the mentorship of
76:Ludwig Institute for Cancer Research
1167:Thomas Jefferson University faculty
13:
1060:"NCI Board of Scientific Advisors"
14:
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1187:University of Cincinnati faculty
82:. She joined the faculty of the
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34:and Enterprise Director of its
23:and its advocacy affiliate the
1132:"About the Editors | Oncogene"
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178:Board of scientific advisors,
19:is Chief Executive Officer of
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781:10.1158/1078-0432.CCR-18-0410
597:10.1158/1078-0432.CCR-18-2207
308:10.1158/0008-5472.CAN-06-4424
208:
40:NCI-designated cancer centers
896:10.1016/j.molcel.2015.04.016
839:10.1158/2159-8290.CD-12-0120
481:10.1158/2159-8290.CD-13-0108
60:George Washington University
7:
539:10.1016/j.ccell.2015.06.004
185:Scientific research board,
117:
44:Thomas Jefferson University
10:
1203:
158:
229:. American Cancer Society
194:Molecular Cancer Research
180:National Cancer Institute
100:National Cancer Institute
93:Molecular Cancer Research
1182:Temple University alumni
769:Clinical Cancer Research
585:Clinical Cancer Research
138:repair, cell cycle, and
953:10.15252/emmm.201708816
941:EMBO Molecular Medicine
664:10.1073/pnas.0506281103
21:American Cancer Society
80:Dr. Webster K. Cavenee
1112:mcr.aacrjournals.org
253:mcr.aacrjournals.org
171:Board of directors,
54:Education and career
1064:deainfo.nci.nih.gov
655:2006PNAS..103.2190B
199:Associate editor,
146:signaling impacts
128:precision medicine
833:(12): 1134–1149.
775:(17): 4201–4214.
591:(18): 5623–5637.
475:(11): 1254–1271.
360:(12): 4478–4492.
302:(13): 6192–6203.
191:Editor-in-chief,
72:Temple University
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17:Karen E. Knudsen
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527:Cancer Cell
164:President,
148:cancer cell
1156:Categories
1141:2020-11-27
1117:2020-11-27
1093:2020-11-27
1069:2020-11-27
1045:2021-01-08
1021:2021-01-08
258:2020-11-27
227:cancer.org
209:References
961:1757-4684
904:1097-4164
847:2159-8290
789:1078-0432
731:0021-9738
673:0027-8424
605:1078-0432
547:1878-3686
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316:0008-5472
277:OncoDaily
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334:17616676
202:Oncogene
144:androgen
140:hormonal
124:oncology
118:Research
970:6284389
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