444:
38:
1914:
596:, while the patch incorporates an occlusive dressing to facilitate absorption of lidocaine and prilocaine into the area where anaesthesia is required. Local dermal anaesthesia is achieved after approximately 60 minutes, whereupon the occlusive dressing (or patch) is removed. The duration of anaesthesia is approximately two hours following removal of the occlusive dressing.
564:
insertion, blood sampling, superficial surgical procedures, and topical anaesthesia of leg ulcers for cleansing or debridement. Also, it can be used to numb the skin before tattooing as well as electrolysis and laser hair removal. It is also sometimes used in advance of injected local anaesthetics
599:
E. Fougera & Co., makers of the generic cream widely used in the United States as
Lidocaine and Prilocaine Cream, 2.5%/2.5%, recommends different timing for application of the cream as well as length of anesthesia. They state the cream must be applied at least one hour before the start of a
619:
concludes in its latest (2014) statement on Emla: "Safety and efficacy for the use of EMLA on genital skin and genital mucosa have not been established in children younger than 12 years. Available paediatric data do not demonstrate adequate efficacy for circumcision."
861:
Dinsmore WW, Wyllie MG (April 2009). "PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before intercourse in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo-controlled study".
623:
The
Patient Information Leaflet of EMLA in the UK states: "EMLA Cream should not be applied to the genital skin (e.g. penis) and genital mucosa (e.g. in the vagina) of children (below 12 years of age) owing to insufficient data on absorption of active substances."
532:
of the mixture is lower than the melting points of the individual components. The lidocaine/prilocaine eutectic mixture is an oil with a melting point of 18 °C, and can be formulated into preparations without the use of a
600:
routine procedure and for two hours before the start of a painful procedure. Additionally, they state that the duration of effective skin anesthesia will be at least one hour after removal of the occlusive dressing.
1595:
801:
1588:
927:
Heinen MM, van
Achterberg T, op Reimer WS, van de Kerkhof PC, de Laat E (March 2004). "Venous leg ulcer patients: a review of the literature on lifestyle and pain-related interventions".
592:
Lidocaine/prilocaine eutectic mixture is marketed as a 5% oil-in-water emulsion incorporated in a cream base (EMLA cream) or a cellulose disk (EMLA patch). The cream is applied under an
1581:
1100:
223:
494:
265:
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Separately, lidocaine and prilocaine are solid bases. When mixed in equal quantities by weight, however, they form a eutectic mixture – that is the
1890:
186:
577:
1149:
1408:
1212:
650:
that is sprayed directly on the penis to numb sensations. It was developed by the same group that invented the erectile dysfunction drug
568:
A topical spray consisting of an aerosol formulation of lidocaine and prilocaine was evaluated under the name PSD502 for use in treating
1062:
993:
Taddio A, Ohlsson K, Ohlsson A (2000). Ohlsson A (ed.). "Lidocaine-prilocaine cream for analgesia during circumcision in newborn boys".
1768:
102:
240:
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solvent. This allows higher concentrations of anaesthetic to be formulated into the preparation and maintained during application.
74:
464:
1949:
1934:
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81:
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55:
1954:
983:
Lidocaine and
Prilocaine Cream, 2.5%/2.5%, package insert. E. Fougera & Co. package insert. Melville, New York, 9/2007.
88:
1179:
1104:
121:
1573:
1556:
70:
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658:
and was released in the UK market in
November 2016 and within the EU will be marketed by, early in 2017 In the
572:. The spray is applied on the penile skin prior to intercourse. While this formulation was not approved by the
59:
1776:
1414:
663:
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1851:
423:
512:(topical eutectic-like mixture for premature ejaculation) (PSD502) that can be used by men to help with
1944:
1939:
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1198:
675:
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218:
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439:
95:
1847:
1544:
1127:"Viagra Inventor Develops 'Tempe Spray' To Help Men Deal With Premature Ejaculation: Is It Safe?"
251:
176:
48:
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in newborn boys and has been considered efficacious and safe to lessen pain from circumcision.
1083:
724:"Emla Cream 5% (for 5 g and pre-medication packs) - Summary of Product Characteristics (SmPC)"
1801:
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8:
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1150:"Revision Bulletin: Lidocaine and Prilocaine Cream–Revision to Related Compounds Test"
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883:
832:"Topical Anesthesia Use in Children: Eutectic Mixture of Local Anesthetics"
644:
609:
1033:. If this is an intentional citation to a retracted paper, please replace
493:
preparation, containing 2.5% each of lidocaine/prilocaine, is marketed by
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1241:
776:"Nulbia 5% cream - Summary of Product Characteristics (SmPC)"
557:. Specifically it is applied to prevent pain associated with
428:
608:
Lidocaine/prilocaine eutectic mixture has been used during
520:
and branded as
Fortacin in the UK and Recordati in the EU.
403:
1084:"Package leaflet: Information for the user EMLA Cream 5%"
1063:"INN of the active substance(s): lidocaine/prilocaine"
906:"EMLA Official FDA information, side effects and uses"
750:"Fortacin - Summary of Product Characteristics (SmPC)"
550:
The lidocaine/prilocaine combination is indicated for
1902:
1070:
Committee for
Medicinal Products for Human Use (CHMP)
992:
62:. Unsourced material may be challenged and removed.
802:"List of nationally authorised medicinal products"
1926:
829:
371:
666:(FDA) is expected to approve the drug in 2018.
346:
860:
1589:
1206:
508:). As a spray, it is marketed under the name
1148:The United States Pharmacopeial Convention.
239:
995:The Cochrane Database of Systematic Reviews
920:
481:mixture of equal quantities (by weight) of
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1582:
1213:
1199:
1047:|...|intentional=yes}}
442:
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122:Learn how and when to remove this message
197:Micromedex Detailed Consumer Information
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14:
1927:
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1194:
1129:. medicaldaily.com. 24 September 2013
506:Eutectic Mixture of Local Anesthetics
308:
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195:
27:Eutectic Mixture of Local Anesthetics
1891:Sexual dysfunction pharmacotherapies
1186:. U.S. National Library of Medicine.
1141:
669:
632:The spray is a combination of local
60:adding citations to reliable sources
31:
1180:"Lidocaine mixture with Prilocaine"
523:
411:
362:
24:
1103:. bio-medicine.org. Archived from
25:
1966:
1172:
1912:
1101:"TEMPE Spray Delays Ejaculation"
941:10.1046/j.1365-2702.2003.00887.x
876:10.1111/j.1464-410X.2009.08456.x
830:Pesaturo KA, Matthews M (2009).
565:for minor surgery and biopsies.
181:Emla, Fortacin, Senstend, others
36:
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516:. The spray is manufactured by
47:needs additional citations for
1950:Drugs developed by AstraZeneca
1935:Drugs not assigned an ATC code
1022:10.1002/14651858.CD000496.pub2
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898:
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13:
1:
1415:3-(p-Fluorobenzoyloxy)tropane
1402:ArCO2- (not para-amino or Ph)
709:
1072:. European Medicines Agency.
664:Food and Drug Administration
7:
1955:Products introduced in 2013
929:Journal of Clinical Nursing
682:
654:. The drug was approved in
10:
1971:
1506:Anesthetic/vasoconstrictor
676:United States Pharmacopeia
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1411:(3,4,5-Trimethoxybenzoyl)
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1003:10.1002/14651858.CD000496
617:European Medicines Agency
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241:Lidocaine_and_prilocaine
1465:Cinchocaine (Dibucaine)
1227:sodium channel blockers
1184:Drug Information Portal
71:"Lidocaine/prilocaine"
1802:premature ejaculation
1735:Melanocortin agonists
1614:premature ejaculation
1511:Bupivacaine/meloxicam
1039:|...}}
1016:(Retracted, see
576:, a similar product,
570:premature ejaculation
514:premature ejaculation
504:(an abbreviation for
1623:erectile dysfunction
1606:erectile dysfunction
1516:Lidocaine/prilocaine
1325:Procaine (Novocaine)
1107:on 27 September 2013
1089:. AstraZeneca. 2017.
963:"PSD502 TEMPE Spray"
475:Lidocaine/prilocaine
136:Lidocaine/prilocaine
56:improve this article
495:APP Pharmaceuticals
138:
1561:Never to phase III
782:. 18 December 2017
756:. 14 November 2018
594:occlusive dressing
518:Plethora Solutions
302:Pharmacy medicines
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1945:Combination drugs
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1717:Dopamine agonists
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1222:Local anesthetics
864:BJU International
811:. 1 December 2022
670:Compendial status
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1152:. Archived from
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965:. Promescent.com
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524:Eutectic mixture
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1551:Clinical trials
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1300:Metabutethamine
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1156:on 5 July 2010
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1887:
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1773:acecarbromal
1748:Melanotan II
1702:Phentolamine
1515:
1499:Combinations
1320:Propoxycaine
1285:Dimethocaine
1252:Aminobenzoic
1183:
1158:. Retrieved
1154:the original
1143:
1133:25 September
1131:. Retrieved
1121:
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1109:. Retrieved
1105:the original
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732:. Retrieved
730:. 4 May 2017
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645:metered-dose
634:anaesthetics
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584:in the U.S.
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281:Legal status
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54:Please help
49:verification
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29:
1860:Amphetamine
1831:antagonists
1725:Apomorphine
1641:Alprostadil
1547:from market
1480:Mepivacaine
1450:Ropivacaine
1442:Bupivacaine
1393:Piperocaine
1295:Meprylcaine
1265:Benzonatate
1225:(primarily
908:. Drugs.com
689:Dosage form
559:intravenous
555:anaesthesia
546:Indications
348:101362-25-8
333:Identifiers
177:Trade names
1929:Categories
1819:Dapoxetine
1787:Papaverine
1697:Moxisylyte
1679:Vardenafil
1664:Sildenafil
1604:Drugs for
1526:Iontocaine
1490:Trimecaine
1485:Prilocaine
1470:Etidocaine
1460:Carticaine
1388:Isobucaine
1383:Hexylcaine
1358:Amylocaine
1340:Tetracaine
1315:Orthocaine
1310:Nitracaine
1260:Benzocaine
710:References
704:Prilocaine
652:sildenafil
641:prilocaine
578:Promescent
499:trade name
497:under the
487:prilocaine
384:ChemSpider
339:CAS Number
160:Prilocaine
82:newspapers
1888:See also:
1838:Epelsiban
1781:vitamin E
1777:quebracho
1707:Yohimbine
1669:Tadalafil
1557:Phase III
1545:Withdrawn
1475:Lidocaine
1437:Articaine
1409:Amoproxan
1378:β-Eucaine
1373:α-Eucaine
1335:Risocaine
1270:Butacaine
1045:retracted
1037:retracted
912:7 January
892:205540753
846:7 January
842:(3): HS-4
699:Lidocaine
637:lidocaine
483:lidocaine
300: P (
252:Routes of
191:Drugs.com
148:Lidocaine
112:July 2009
1919:Medicine
1829:Oxytocin
1674:Udenafil
1659:Avanafil
1275:Butamben
1030:25840001
1011:10796371
949:15009338
884:19245438
836:US Pharm
683:See also
562:catheter
491:emulsion
479:eutectic
465:(verify)
266:ATC code
236:DailyMed
1769:Afrodor
1753:PL-6983
1363:Cocaine
1350:Benzoic
1290:Lucaine
1244:by acid
1160:10 July
815:13 June
648:aerosol
535:aqueous
489:. A 5%
393:8087472
373:9911821
359:PubChem
259:Topical
238::
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96:scholar
1905:Portal
1762:Others
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1540:WHO-EM
1429:Amides
1242:Esters
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315:℞-only
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477:is a
103:JSTOR
89:books
1852:DRIs
1800:For
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1233:N01B
1162:2009
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1026:PMID
1007:PMID
971:2014
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762:2020
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485:and
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273:None
187:AHFS
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