26:
170:
34:
784:
630:
Carlos J. Rosado; Ashley M. Buckle; Ruby H. P. Law; Rebecca E. Butcher; Wan-Ting Kan; Catherina H. Bird; Kheng Ung; Kylie A. Browne; Katherine Baran; Tanya A. Bashtannyk-Puhalovich; Noel G. Faux; Wilson Wong; Corrine J. Porter; Robert N. Pike; Andrew M. Ellisdon; Mary C. Pearce; Stephen P. Bottomley;
110:
A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-6-7 complex. The C5b-6-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-6-7-8 complex. C5b-6-7-8
236:
C8 alpha-gamma has the hydrophobic area that inserts into the bilayer. C8 alpha-gamma induces the polymerization of 10-16 molecules of C9 into a pore-forming structure known as the membrane attack complex.
631:
Jonas Emsley; A. Ian Smith; Jamie
Rossjohn; Elizabeth L. Hartland; Ilia Voskoboinik; Joseph A. Trapani; Phillip I. Bird; Michelle A. Dunstone & James C. Whisstock (2007).
214:
This junction alters the configuration of the protein molecules exposing a hydrophobic site on C7 that allows the C7 to insert into the phospholipid bilayer of the pathogen.
579:
Tschopp J, Masson D, Stanley KK (1986). "Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis".
788:
266:
Multiple molecules of C9 can join spontaneously in concentrated solution to form polymers of C9. These polymers can also form a tube-like structure.
432:
Stanley KK, Marazziti D, Eggertsen G, Fey GH (1988). "Relationships between the gene and protein structure in human complement component C9".
76:-mediated complement activation leads to MAC deposition on the surface of infected cells. Assembly of the MAC leads to pores that disrupt the
826:
289:
Deficiencies of C5 to C9 components do not lead to a generalized susceptibility to infections but only to an increased susceptibility to
127:, and many copies of a fifth protein (C9) that hook up to one another, forming a ring in the membrane. C6-C9 all contain a common
316:
763:
321:
278:
153:(sC5b-7, sC5b-8 and sC5b-9). These fluid phase complexes do not bind to cell membranes and are ultimately scavenged by
149:
If the pre-MAC complexes of C5b-7, C5b-8 or C5b-9 do not insert into a membrane, they can form inactive complexes with
357:
819:
859:
194:
794:
25:
849:
186:
1241:
812:
1095:
798:
277:
acts to inhibit the complex. This exists on body cells to protect them from MAC. A rare condition,
146:
of molecules in and out of the cell. If enough pores form, the cell is no longer able to survive.
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1045:
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1005:
900:
895:
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molecules are exposed when they bind to the complex, so they can also insert into the bilayer.
227:
208:
201:
182:
104:
96:
92:
88:
741:
690:"Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9"
522:"Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9"
353:"Complement Membrane Attack Complex: New Roles, Mechanisms of Action, and Therapeutic Targets"
1147:
1142:
943:
1157:
1152:
644:
588:
533:
281:, results in red blood cells that lack CD59. These cells can, therefore, be lysed by MAC.
8:
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406:
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111:
subsequently binds to C9 and acts as a catalyst in the polymerization of C9.
77:
69:
61:
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The ring structure formed by C9 is a pore in the membrane that allows free
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304:
223:
100:
963:
600:
520:
Fey GH, Hugli TE, Podack ER, Gehring MR, Kan CC, DiScipio RG (1984).
300:
291:
233:
C8 is a complex made of the two proteins C8-beta and C8 alpha-gamma.
177:
The membrane attack complex is initiated when the complement protein
154:
150:
143:
136:
804:
736:
Ronald
Hoffman, Leslie E. Silberstein, Helen Heslop, Jeffrey Weitz,
466:
169:
1124:
958:
326:
73:
58:
33:
120:
633:"A Common Fold Mediates Vertebrate Defense and Bacterial Attack"
783:
185:
into C5a and C5b. All three pathways of the complement system (
758:(6th ed.). Philadelphia, PA: Elsevier. pp. 158–176.
756:
Basic
Immunology: Functions and Disorders of the Immune System
57:) is a complex of proteins typically formed on the surface of
1166:
128:
81:
20:
473:"The sequence and topology of human complement component C9"
431:
123:(C5b, C6, C7, and C8) that bind to the outer surface of the
1170:
1099:
993:
274:
29:
Membrane attack complex (Terminal complement complex C5b-9)
405:
Janeway, CA Jr; Travers P; Walport M; et al. (2001).
989:
917:
912:
404:
37:
A membrane attack complex attached to a pathogenic cell
411:
Immunobiology: The Immune System in Health and
Disease
519:
578:
87:The MAC is composed of the complement components
1233:
350:
119:MAC is composed of a complex of four complement
400:
398:
820:
623:
64:as a result of the activation of the host's
407:"The complement system and innate immunity"
395:
344:
827:
813:
513:
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425:
797:at the U.S. National Library of Medicine
738:Hematology: Basic Principles and Practice
713:
656:
555:
545:
496:
378:
197:pathways) initiate the formation of MAC.
114:
217:
168:
32:
24:
687:
1234:
317:Terminal complement pathway deficiency
834:
808:
753:
351:Xie CB, Jane-Wit D, Pober JS (2020).
322:Paroxysmal nocturnal haemoglobinuria
279:paroxysmal nocturnal haemoglobinuria
164:
68:, and as such is an effector of the
13:
795:Complement+Membrane+Attack+Complex
789:Complement membrane attack complex
489:10.1002/j.1460-2075.1985.tb03639.x
248:allowing it to associate with the
14:
1263:
776:
358:The American Journal of Pathology
80:of target cells, leading to cell
782:
161:, two regulators of complement.
747:
471:; Kocher HP; Jackson P (1985).
730:
681:
572:
262:to allow the passage of water.
207:The C5bC6 complex is bound by
1:
337:
269:
222:Similar hydrophobic sites on
139:from Gram-positive bacteria.
706:10.1016/j.celrep.2012.02.003
526:Proc. Natl. Acad. Sci. U.S.A
371:10.1016/j.ajpath.2020.02.006
284:
200:Another complement protein,
7:
740:, 6th ed., Elsevier, 2013,
413:. New York: Garland Science
310:
51:terminal complement complex
10:
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18:
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1133:
1096:Decay-accelerating factor
1080:
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135:to cholesterol-dependent
799:Medical Subject Headings
754:Abbas, Abul K. (2020).
658:10.1126/science.1144706
547:10.1073/pnas.81.23.7298
173:Membrane attack complex
131:domain. This region is
43:membrane attack complex
467:Stanley KK; Luzio JP;
174:
115:Structure and function
38:
30:
218:Polymerization: C8-C9
172:
36:
28:
1135:Complement receptors
791:at Wikimedia Commons
688:Hadders, MA (2012).
649:2007Sci...317.1548R
593:1986Natur.322..831T
538:1984PNAS...81.7298D
446:10.1021/bi00417a050
964:Factor P/Properdin
869:Activators/enzymes
332:Pore-forming toxin
295:infections, since
175:
39:
31:
1242:Complement system
1229:
1228:
1076:
1075:
836:Complement system
787:Media related to
765:978-0-323-54943-1
643:(5844): 1548–51.
532:(23): 7298–7302.
440:(17): 6529–6534.
303:and little to no
165:Initiation: C5-C7
66:complement system
1259:
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365:(6): 1138–1150.
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62:cell membranes
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1020:C3-convertase
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1221:Opsonization
1216:inflammation
1204:Cytotoxicity
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1091:C1-inhibitor
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434:Biochemistry
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415:. Retrieved
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103:and several
86:
54:
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257:hydrophilic
243:hydrophobic
195:alternative
159:vitronectin
107:molecules.
84:and death.
1252:Immunology
1236:Categories
1081:Inhibitors
338:References
305:glycocalyx
270:Inhibition
255:MAC has a
241:MAC has a
137:cytolysins
133:homologous
19:See also:
1214:Inducing
469:Tschopp J
417:4 January
301:cell wall
297:Neisseria
292:Neisseria
285:Pathology
187:classical
155:clusterin
151:Protein S
144:diffusion
1206:(by MAC)
1197:Function
1125:Factor H
1105:Factor I
959:Factor D
954:Factor B
843:Pathways
742:page 231
724:22832194
694:Cell Rep
675:20372720
667:17717151
389:32194049
327:Perforin
311:See also
181:cleaves
121:proteins
74:Antibody
59:pathogen
715:3314296
645:Bibcode
637:Science
617:4330219
609:2427956
589:Bibcode
566:6095282
534:Bibcode
507:4018030
454:3219351
380:7280757
973:Middle
801:(MeSH)
762:
722:
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673:
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615:
607:
581:Nature
564:
557:392133
554:
505:
498:554196
495:
477:EMBO J
452:
387:
377:
191:lectin
1167:CD11c
1163:CD11b
939:MASP2
935:MASP1
876:Early
671:S2CID
613:S2CID
129:MACPF
82:lysis
49:) or
21:MACPF
1171:CD18
1115:C4BP
1100:CD59
1088:CLA:
1034:Late
994:iC3b
760:ISBN
720:PMID
663:PMID
605:PMID
562:PMID
503:PMID
450:PMID
419:2018
385:PMID
275:CD59
226:and
193:and
157:and
41:The
1186:C5a
1181:C3a
1158:CR4
1153:CR3
1148:CR2
1143:CR1
1112:CL:
1046:C5b
1041:MAC
1011:C5b
1006:C5a
990:C3b
985:C3a
944:MBL
918:C4b
913:C4a
901:C1s
896:C1r
891:C1q
710:PMC
702:doi
653:doi
641:317
597:doi
585:322
552:PMC
542:doi
493:PMC
485:doi
442:doi
375:PMC
367:doi
363:190
89:C5b
55:TCC
47:MAC
1238::
1122:A:
1066:C9
1061:C8
1056:C7
1051:C6
1001:C5
980:C3
951:A:
932:L:
925:C2
908:C4
886:C1
883:C:
718:.
708:.
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530:81
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438:27
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409:.
397:^
383:.
373:.
361:.
355:.
307:.
228:C9
224:C8
211:.
209:C7
202:C6
189:,
183:C5
105:C9
101:C8
99:,
97:C7
95:,
93:C6
91:,
72:.
1169:/
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1098:/
992:/
937:/
860:A
855:L
850:C
828:e
821:t
814:v
768:.
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704::
698:1
677:.
655::
647::
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599::
591::
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544::
536::
509:.
487::
481:4
456:.
444::
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391:.
369::
252:.
53:(
45:(
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