203:
has resulted in the continuing exponential growth of the CAZy database, which now covers hundreds of thousands of sequences. CAZy continues to be curated and developed by the
Glycogenomics group at AFMB, a research centre affiliated with the
241:
fold. These families are clustered into 14 different clans that share structural similarity. CAZy contains 94 families of
Glycosyl transferase enzymes, 22 families of polysaccharide lysases and 16 families of carbohydrate esterases.
233:
CAZy identifies evolutionarily related families of glycosyl hydrolases using the classification introduced by
Bernard Henrissat. These families are given a number to identify them, so for example
520:
Armenta, Silvia; Moreno-Mendieta, Silvia; Sánchez-Cuapio, Zaira; Sánchez, Sergio; RodrĂguez-Sanoja, Romina (2017). "Advances in molecular engineering of carbohydrate-binding modules".
34:
408:
Coutinho, P. M.; Deleury, E.; Davies, G. J.; Henrissat, B. (2003). "An evolving hierarchical family classification for glycosyltransferases".
205:
65:
132:
is a database of
Carbohydrate-Active enZYmes (CAZymes). The database contains a classification and associated information about
845:. Architecture et Fonction des Macromolécules Biologiques, CNRS, Université de Provence Université de la Méditerranée.
876:
370:
Henrissat, B.; Davies, G. (1997). "Structural and sequence-based classification of glycoside hydrolases".
234:
173:
191:-based family classification of CAZymes, which was originally developed in early 1990s to classify the
871:
209:
565:"Expansion of the enzymatic repertoire of the CAZy database to integrate auxiliary redox enzymes"
187:
CAZy was established in 1999 in order to provide online and constantly updated access to the
446:
Lombard, V.; Bernard, T.; Rancurel, C.; Brumer, H.; Coutinho, P. M.; Henrissat, B. (2010).
8:
620:
447:
192:
161:
157:
20:
675:
621:"Sorting the diverse: The sequence‑based classifications of carbohydrate‑active enzymes"
318:
Cantarel BL, Coutinho PM, Rancurel C, Bernard T, Lombard V, Henrissat B (January 2009).
815:
790:
591:
564:
545:
344:
320:"The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics"
319:
292:
267:
421:
383:
820:
771:
766:
596:
537:
469:
425:
387:
349:
297:
266:
Lombard, V.; Golaconda Ramulu, H.; Drula, E.; Coutinho, P. M.; Henrissat, B. (2014).
549:
810:
802:
791:"A classification of glycosyl hydrolases based on amino acid sequence similarities"
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287:
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188:
667:
663:
145:
108:
59:
671:
659:
655:
505:
488:
19:
This article is about the database. For the community in the United States, see
200:
181:
153:
149:
740:"Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes"
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117:
756:
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519:
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195:. New entries are added shortly after they appear in the daily releases of
141:
137:
824:
448:"A hierarchical classification of polysaccharide lyases for glycogenomics"
391:
283:
176:. The CAZy database also includes a classification of Auxiliary Activity
335:
640:
563:
Levasseur A, Drula E, Lombard V, Coutinho PM, Henrissat B (March 2013).
487:
Nakamura, Aline M.; Nascimento, Alessandro S.; Polikarpov, Igor (2017).
713:
533:
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238:
806:
688:
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169:
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involved in the synthesis, metabolism, and recognition of complex
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221:, which was launched in 2007 as a research community-driven,
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33:
714:"AFMB UMR 7257 - UMR7257 : CNRS - AIX MARSEILLE UNIV"
607:
731:
268:"The carbohydrate-active enzymes database (CAZy) in 2013"
842:
96:
782:
737:
313:
311:
863:
489:"Structural diversity of carbohydrate esterases"
261:
259:
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855:The Encyclopedia of Carbohydrate-Active Enzymes
369:
308:
206:French National Centre for Scientific Research
66:French National Centre for Scientific Research
843:"CAZy - Carbohydrate-Active enZYmes Database"
681:
618:
252:
156:. Included in the database are families of
118:http://mothra.ornl.gov/cgi-bin/cat/cat.cgi
814:
788:
765:
755:
654:Current statistics are available on each
639:
590:
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199:. The rapid evolution of high-throughput
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493:Biotechnology Research and Innovation
372:Current Opinion in Structural Biology
180:enzymes involved in the breakdown of
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441:
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49:carbohydrate-active enzymes database
13:
215:The CAZy database is coupled with
14:
888:
835:
436:
398:
360:
228:
237:contains enzymes that possess a
225:-based encyclopedia of CAZymes.
32:
648:
619:Davies GJ, Sinnott ML (2008).
513:
480:
122:http://csbl.bmb.uga.edu/dbCAN/
1:
738:CAZypedia Consortium (2018).
422:10.1016/S0022-2836(03)00307-3
384:10.1016/S0959-440X(97)80072-3
245:
410:Journal of Molecular Biology
174:carbohydrate-binding modules
7:
676:Carbohydrate-Binding Module
506:10.1016/j.biori.2017.02.001
235:Glycosyl hydrolase family 1
114:http://research.ahv.dk/cazy
10:
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330:(Database issue): D233–8.
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767:21.11116/0000-0003-B7EB-6
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45:
40:
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210:Aix-Marseille University
83:Lombard & al. (2014)
795:The Biochemical Journal
877:Protein classification
789:Henrissat, B. (1991).
582:10.1186/1754-6834-6-41
272:Nucleic Acids Research
757:10.1093/glycob/cwx089
668:Carbohydrate Esterase
718:www.afmb.univ-mrs.fr
664:Polysaccharide Lyase
193:glycoside hydrolases
172:, and non-catalytic
162:glycosyltransferases
158:glycoside hydrolases
97:http://www.cazy.org/
660:Glycosyltransferase
656:Glycoside Hydrolase
641:10.1042/BIO03004026
569:Biotechnol Biofuels
452:Biochemical Journal
284:10.1093/nar/gkt1178
75:Glycogenomics group
28:
21:Cazy, West Virginia
672:Auxiliary-Activity
534:10.1002/prot.25327
465:10.1042/BJ20101185
336:10.1093/nar/gkn663
164:, polysaccharide
26:
807:10.1042/bj2800309
801:(Pt 2): 309–316.
324:Nucleic Acids Res
278:(D1): D490–D495.
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528:(9): 1602–1617.
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189:protein sequence
146:oligosaccharides
80:Primary citation
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168:, carbohydrate
154:glycoconjugates
150:polysaccharides
60:Research center
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16:Enzyme database
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836:External links
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628:The Biochemist
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458:(3): 437–444.
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416:(2): 307–317.
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378:(5): 637–644.
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229:Classification
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201:DNA sequencing
182:lignocellulose
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721:. Retrieved
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696:. Retrieved
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634:(4): 26–32.
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851:"CAZypedia"
723:3 September
698:3 September
46:Description
866:Categories
750:(1): 3–8.
246:References
239:TIM barrel
72:Laboratory
575:(1): 41.
218:CAZypedia
170:esterases
776:29040563
693:CAZy.org
601:23514094
550:26493197
542:28547780
522:Proteins
474:20925655
430:12691742
354:18838391
302:24270786
825:1747104
816:1130547
689:"About"
592:3620520
392:9345621
345:2686590
293:3965031
197:GenBank
140:, i.e.
134:enzymes
93:Website
54:Contact
41:Content
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674:, and
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166:lyases
152:, and
88:Access
64:AFMB,
624:(PDF)
546:S2CID
178:redox
103:Tools
821:PMID
772:PMID
725:2014
700:2014
597:PMID
538:PMID
470:PMID
426:PMID
388:PMID
350:PMID
298:PMID
223:wiki
208:and
130:CAZy
27:CAZy
811:PMC
803:doi
799:280
762:hdl
752:doi
636:doi
587:PMC
577:doi
530:doi
501:doi
460:doi
456:432
418:doi
414:328
380:doi
340:PMC
332:doi
288:PMC
280:doi
109:Web
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
