216:
26:
361:. The overall protein structural conservation within the CAP superfamily results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The
369:
function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two
174:
220:
crystal structure of stecrisp, a member of crisp family from trimeresurus stejnegeri refined at 1.6 angstroms resolution: structural relationship of the two domains
546:"The CAP Superfamily: Cysteine-Rich Secretory Proteins, Antigen 5, and Pathogenesis-Related 1 Proteins--Roles in Reproduction, Cancer, and Immune Defense"
585:
Semb, B. K.; Halvorsen, J. F.; Fossdal, J. E. (1977). "Acute gastric volvulus with necrosis of the stomach and the left lower pulmonary lobe".
505:"Isolation and Characterization of a Cone Snail Protease with Homology to CRISP Proteins of the Pathogenesis-related Protein Superfamily"
617:"The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling"
110:
194:
313:
containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often
306:
382:
692:
182:
386:
265:
178:
123:
687:
615:
Gibbs GM, Scanlon MJ, Swarbrick J, Curtis S, Gallant E, Dulhunty AF, O'Bryan MK (February 2006).
451:"New knowledge from old: In silico discovery of novel protein domains in Streptomyces coelicolor"
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161:
8:
429:
272:
130:
79:
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115:
54:
628:
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135:
67:
670:
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402:
244:
91:
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Milne, T. J.; Abbenante, G.; Tyndall, J. D.; Halliday, J.; Lewis, R. J. (2003).
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681:
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330:
642:
633:
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function and are involved in processes including the regulation of
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239:
86:
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CAP superfamily include: the human glioma pathogenesis-related 1 (
362:
98:
346:
298:
215:
189:
25:
502:
425:
301:), Golgi associated pathogenesis related-1 (GAPR1) proteins,
654:
614:
309:(CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP
151:
74:
61:
49:
279:
that are produced by a wide range of organisms, including
543:
653:
This article incorporates text from the public domain
584:
544:Gibbs, G. M.; Roelants, K.; O'Bryan, M. K. (2008).
448:
30:crystal structure of golgi-associated pr-1 protein
679:
498:
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610:
608:
537:
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442:
449:Yeats, C.; Bentley, S.; Bateman, A. (2003).
385:(Crisp) domain. This domain is found in the
381:Many of these proteins contain a C-terminal
605:
578:
214:
24:
632:
561:
520:
476:
466:
305:(PI15), peptidase inhibitor 16 (PI16),
680:
357:; and in cell-cell adhesion during
13:
14:
704:
397:, and has been shown to regulate
260:ysteine-rich secretory proteins,
307:cysteine-rich secretory proteins
509:Journal of Biological Chemistry
383:Cysteine-rich secretory protein
353:genes in tissues including the
1:
435:
146:Available protein structures:
587:Acta Chirurgica Scandinavica
387:mammalian reproductive tract
293:The nine subfamilies of the
7:
337:or protease inhibitors; in
271:proteins (CAP)) is a large
10:
709:
652:
412:which are all involved in
317:and have an extracellular
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23:
18:
333:, potentially as either
634:10.1074/jbc.M506849200
522:10.1074/jbc.M304843200
303:peptidase inhibitor 15
693:Protein superfamilies
468:10.1186/1471-2180-3-3
269:athogenesis-related 1
563:10.1210/er.2008-0032
327:extracellular matrix
515:(33): 31105–31110.
399:ryanodine receptor
349:suppressor or pro-
550:Endocrine Reviews
405:. It contains 10
277:secreted proteins
250:
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204:
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200:
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195:structure summary
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455:BMC Microbiology
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414:disulphide bonds
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688:Protein domains
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420:related to the
254:CAP superfamily
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31:
12:
11:
5:
706:
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668:
662:
649:
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627:(7): 4156–63.
604:
593:(4): 256–258.
577:
556:(7): 865–897.
536:
492:
440:
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341:regulation in
329:and branching
264:ntigen 5, and
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621:J. Biol. Chem
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359:fertilisation
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331:morphogenesis
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234:Crisp-related
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209:Crisp-related
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27:
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512:
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454:
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418:structurally
380:
292:
266:
261:
257:
253:
251:
422:ion channel
339:ion channel
311:LCCL domain
281:prokaryotes
273:superfamily
226:Identifiers
36:Identifiers
682:Categories
436:References
424:inhibitor
403:signalling
372:histidines
288:eukaryotes
285:vertebrate
158:structures
131:Membranome
671:IPR013871
666:IPR014044
410:cysteines
407:conserved
376:glutamate
367:chelating
351:oncogenic
343:fertility
335:proteases
323:paracrine
319:endocrine
295:mammalian
245:IPR001283
104:PDOC00835
92:IPR014044
659:InterPro
643:16339766
572:18824526
531:12759345
487:12625841
428:BgK and
401:calcium
395:reptiles
389:and the
355:prostate
315:secreted
283:and non-
240:InterPro
175:RCSB PDB
87:InterPro
416:and is
363:calcium
99:PROSITE
80:273.1.1
55:PF00188
641:
599:906761
597:
570:
529:
485:
478:151604
475:
426:toxins
374:and a
347:tumour
299:GLIPR1
231:Symbol
190:PDBsum
164:
154:
124:SUPFAM
68:CL0659
41:Symbol
461:: 3.
391:venom
345:; as
120:SCOPe
111:SCOP2
657:and
655:Pfam
639:PMID
595:PMID
568:PMID
527:PMID
483:PMID
252:The
183:PDBj
179:PDBe
162:ECOD
152:Pfam
116:1s0p
75:ECOD
64:clan
62:Pfam
50:Pfam
629:doi
625:281
591:143
558:doi
517:doi
513:278
473:PMC
463:doi
430:ShK
393:of
321:or
275:of
170:PDB
136:209
44:CAP
19:CAP
684::
661::
637:.
623:.
619:.
607:^
589:.
566:.
554:29
552:.
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511:.
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495:^
481:.
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160:/
122:/
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645:.
631::
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574:.
560::
533:.
519::
489:.
465::
459:3
365:-
267:p
262:a
258:c
256:(
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