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293:. Since the early days, Musacchio's lab adopted a multi-disciplinary approach merging structural biology, biochemistry and cellular biology, this way gaining comprehensive views on protein functions in living cells. He is best known for his work on Mad1/Mad2 complexes, which led to the formulation of the
1124:
Basilico, F; Maffini, S; Weir, JR; Prumbaum, D; Rojas, AM; Zimniak, T; De Antoni, A; Jeganethan, S; Voss, B; van Gerwen, S; Krenn, V; Massimiliano, L; Valencia, A; Vetter, IR; Herzog, F; Raunser, S; Pasqualato, S; Musacchio, A (Jul 8, 2014).
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Petrovic, A; Mosalaganti, S; Keller, J; Mattiuzzo, M; Overlack, K; Krenn, V; De Antoni, A; Wohlgemuth, S; Cecatiello, V; Pasqualato, S; Raunser, S; Musacchio, A (Feb 20, 2014).
373:
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Macias, MJ; Musacchio, A; Ponstingl, H; Nilges, M; Saraste, M; Oschkinat, H (Jun 23, 1994). "Structure of the pleckstrin homology domain from beta-spectrin".
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De Antoni, A; Pearson, CG; Cimini, D; Canman, JC; Sala, V; Nezi, L; Mapelli, M; Sironi, L; Faretta, M; Salmon, ED; Musacchio, A (Feb 8, 2005).
251:
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Ciferri, C; Pasqualato, S; Screpanti, E; Varetti, G; Santaguida, S; Dos Reis, G; Maiolica, A; Polka, J; De Luca, JG; De Wulf, P; Salek, M;
624:"Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint"
250:
Young
Investigator from 2000-2004. Musacchio moved to Dortmund in 2011 to direct the Department of Mechanistic Cell Biology at the
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883:"Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine"
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Musacchio, A; Noble, M; Pauptit, R; Wierenga, R; Saraste, M (Oct 29, 1992). "Crystal structure of a Src-homology 3 (SH3) domain".
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Sessa, F; Mapelli, M; Ciferri, C; Tarricone, C; Areces, LB; Schneider, TR; Stukenberg, PT; Musacchio, A (Apr 29, 2005).
188:
118:
83:
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534:"Functional Organization of Clathrin in Coats: Combining Electron Cryomicroscopy and X-Ray Crystallography"
834:"Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction"
305:. In 2008, the structure of the Ndc80 complex set the foundation of a new line of his investigations on
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672:
977:"Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex"
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285:. As an independent scientist, his interests focused on the understanding of the molecular basis of
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1075:"Modular assembly of RWD domains on the Mis12 complex underlies outer kinetochore organization"
673:"The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint"
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The
Department of Mechanistic Cell Biology at the Max Planck Institute of Molecular Physiology
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733:"The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint"
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Musacchio, A; Smith, CJ; Roseman, AM; Harrison, SC; Kirchhausen, T; Pearse, BM (Jun 1999).
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155:(born July 11, 1964) is an Italian structural biologist. He is Max Planck director at the
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domains. During his post-doctoral training, he was involved in the determination of the
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Sironi, L; Mapelli, M; Knapp, S; De Antoni, A; Jeang, KT; Musacchio, A (May 15, 2002).
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Santaguida, S; Vernieri, C; Villa, F; Ciliberto, A; Musacchio, A (Apr 20, 2011).
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Musacchio spent his childhood in Rome, where he grew to be a strong supporter of
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De Antoni, A; Maffini, S; Knapp, S; Musacchio, A; Santaguida, S (Oct 15, 2012).
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Santaguida, S; Tighe, A; D'Alise, AM; Taylor, SS; Musacchio, A (Jul 12, 2010).
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932:"Mechanism of Aurora B activation by INCENP and inhibition by hesperadin"
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Mapelli, M; Massimiliano, L; Santaguida, S; Musacchio, A (Nov 16, 2007).
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All structures deposited at the PDB repository by Andrea
Musacchio
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1127:"The pseudo GTPase CENP-M drives human kinetochore assembly"
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triskelion structure, one of the first studies combining
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Members of the
European Molecular Biology Organization
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261:Musacchio approached structural biology during his
159:in Dortmund. He is also Honorary Professor at the
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252:Max Planck Institute for Molecular Physiology
123:Max Planck Institute for Molecular Physiology
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242:, where he started working on mechanisms of
1024:Santaguida, S; Musacchio, A (Sep 2, 2009).
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1026:"The life and miracles of kinetochores"
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331:He is married and father of two boys.
1239:University of Rome Tor Vergata alumni
216:European Molecular Biology Laboratory
88:European Molecular Biology Laboratory
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157:Institute of Molecular Physiology
575:"How do so few control so many?"
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161:Center for Medical Biotechnology
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1224:Heidelberg University alumni
1092:10.1016/j.molcel.2014.01.019
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165:University of Duisburg-Essen
139:Other academic advisors
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887:The Journal of Cell Biology
789:The Journal of Cell Biology
573:Nasmyth, K (Mar 25, 2005).
324:. He has started embracing
309:assembly and attachment to
291:spindle assembly checkpoint
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214:in 1995 working at the
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228:Harvard Medical School
115:Harvard Medical School
899:10.1083/jcb.201001036
850:10.1038/emboj.2011.70
801:10.1083/jcb.201205119
389:Musacchio A. (2012).
301:, Mps1 and Haspin in
279:X-ray crystallography
212:Heidelberg University
179:Musacchio received a
1219:Scientists from Rome
1189:ResearchGate profile
175:Education and career
1144:10.7554/elife.02978
495:1994Natur.369..675M
444:1992Natur.359..851M
348:"Musacchio, Andrea"
283:electron microscopy
224:Stephen C. Harrison
391:"Andrea Musacchio"
376:2014-12-09 at the
226:laboratory at the
222:studies he joined
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167:. He was named
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105:Crystallography
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1209:1964 births
307:kinetochore
246:. He was a
210:, from the
70:Nationality
1198:Categories
1137:: e02978.
701:2434/65744
357:2024-01-12
352:www.mpg.de
335:References
218:. For his
48:1964-07-11
322:A.S. Roma
208:cum laude
196:cum laude
187:from the
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374:Archived
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257:Research
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263:Ph.D.
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38:Born
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