613:
716:. The importance of sortilin in p75NTR-mediated apoptosis is exhibited by the fact that the inhibition of sortilin expression in neurons expressing p75NTR suppresses proNGF-mediated apoptosis, and the prevention of proBDNF binding to p75NTR and sortilin abolished apoptotic action. Activation of p75NTR-mediated apoptosis is much more effective in the absence of Trk receptors due to the fact that activated Trk receptors suppress the JNK cascade.
36:
739:, because whether they induce apoptosis or survival is dependent on the presence of neurotrophins. The expression of TrkB, which is found mainly in the CNS, does not cause apoptosis. This is thought to be because it is differentially located in the cell membrane while TrkA and TrkC are co-localized with p75NTR in
813:
experiments were conducted to identify the neuronal populations in both the PNS and CNS that were affected by the loss of different neurotrophins during development and the extent to which these populations were affected. These knockout experiments resulted in the loss of several neuron populations
487:
Despite its name, BDNF is actually found in a range of tissue and cell types, not just the brain. Expression can be seen in the retina, the CNS, motor neurons, the kidneys, and the prostate. Exercise has been shown to increase the amount of BDNF and therefore serve as a vehicle for neuroplasticity.
596:(around 5 nM), and hence as so-called "microneurotrophins". DHEA has also been found to bind to the TrkB and TrkC, though while it activated the TrkC, it was unable to activate the TrkB. It has been proposed that DHEA may have been the ancestral ligand of the Trk receptors early on in the
479:
BDNF is one of the most active substances to stimulate neurogenesis. Mice born without the ability to make BDNF suffer developmental defects in the brain and sensory nervous system, and usually die soon after birth, suggesting that BDNF plays an important role in normal
328:
In the peripheral and central neurons, neurotrophins are important regulators for survival, differentiation, and maintenance of nerve cells. They are small proteins that secrete into the nervous system to help keep nerve cells alive. There are two distinct classes of
857:
and minor losses of their DRG, trigeminal ganglia and vestibular ganglia. The NT-4-knockout mice also had minor losses of facial motoneurons. These mice were very viable. The NT-3 knockout mice had losses of a majority of their DRG, trigeminal ganglia,
866:. These mice had very poor viability. These results show that the absence of different neurotrophins result in losses of different neuron populations (mainly in the PNS). Furthermore, the absence of the neurotrophin survival signal leads to apoptosis.
798:
and function rather than survival. For these reasons, compared to neurons in the PNS, neurons of the CNS are less sensitive to the absence of a single neurotrophin or neurotrophin receptor during development; with the exception being neurons in the
635:(PCD) of neurons. Neurotrophic survival signals in neurons are mediated by the high-affinity binding of neurotrophins to their respective Trk receptor. In turn, a majority of neuronal apoptotic signals are mediated by neurotrophins binding to the
312:
outgrowths that contact their target cells. Such cells control their degree of innervation (the number of axon connections) by the secretion of various specific neurotrophic factors that are essential for neuron survival. One of these is
1629:
Gravanis A, Calogeropoulou T, Panoutsakopoulou V, Thermos K, Neophytou C, Charalampopoulos I (October 2012). "Neurosteroids and microneurotrophins signal through NGF receptors to induce prosurvival signaling in neuronal cells".
307:
During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out
2380:– 'Neurotrophin Receptors: The neurotrophin family consists of four members: nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4)' (April 4, 2003)
513:
NT-3 is unique among the neurotrophins in the number of neurons it has potential to stimulate, given its ability to activate two of the receptor tyrosine kinase neurotrophin receptors (
1122:
Neurotrophic factors are polypeptides or small proteins that support the growth, differentiation, and survival of neurons. They produce their effects by activation of tyrosine kinases.
4900:
502:
Neurotrophin-3, or NT-3, is a neurotrophic factor, in the NGF-family of neurotrophins. It is a protein growth factor that has activity on certain neurons of the peripheral and
4920:
647:
and differentiating neurons. It is necessary because during development there is a massive over production of neurons which must be killed off to attain optimal function.
905:
4910:
2689:
3065:
341:, which are each specific for different neurotrophins. The reported structure above is a 2.6 Å-resolution crystal structure of neurotrophin-3 (NT-3) complexed to the
144:
854:
325:(CNS), but slight traces have been detected in adult CNS tissues, although a physiological role for this is unknown. It has also been found in several snake venoms.
198:
proteins that can signal particular cells to survive, differentiate, or grow. Growth factors such as neurotrophins that promote the survival of neurons are known as
1279:
Koyama J, Inoue S, Ikeda K, Hayashi K (December 1992). "Purification and amino-acid sequence of a nerve growth factor from the venom of Vipera russelli russelli".
4895:
862:
and superior cervical ganglia and moderate losses of nodose petrosal ganglia and vestibular ganglia. In addition the NT-3-knockout mice had moderate losses of
666:. Unlike mature neurotrophins which bind to the p75NTR with a low affinity, proNTs preferentially bind to the p75NTR with high affinity. The p75NTR contains a
3430:
476:– areas vital to learning, memory, and higher thinking. BDNF was the second neurotrophic factor to be characterized, after NGF and before neurotrophin-3.
448:
and the peripheral nervous system; it helps to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and
2395:
1467:
859:
662:
pathways which are important in regulating apoptosis. Proneurotrophins (proNTs) are neurotrophins which are released as biologically active uncleaved
849:
and moderate losses of their DRG, trigeminal ganglia, nodose petrosal ganglia and cochlear ganglia. In addition they also had minor losses of their
4665:
2740:
1534:
Lazaridis I, Charalampopoulos I, Alexaki VI, Avlonitis N, Pediaditakis I, Efstathopoulos P, Calogeropoulou T, Castanas E, Gravanis A (April 2011).
4604:
1454:"Exercise builds brain health: key roles of growth factor cascades and inflammation" by Carl W. Cotman, Nicole C. Berchtold and Lori-Ann Christie
3781:
2973:
2682:
2332:
Ernsberger U (June 2009). "Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia".
5564:
3706:
2651:
2438:
5288:
5201:
5146:
5100:
5045:
4780:
4720:
3721:
3651:
3210:
2808:
2750:
2136:
Longo FM, Massa SM (July 2013). "Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease".
506:; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and
5283:
5161:
5060:
4846:
4735:
4535:
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4243:
4162:
4024:
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3726:
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3542:
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3307:
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5241:
5220:
5176:
5156:
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5055:
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4373:
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3701:
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2755:
2504:
2411:
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4785:
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242:
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5065:
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4190:
4180:
4132:
4114:
4043:
3877:
3716:
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636:
368:
334:
414:
on the neuron, and is internalized into the responsive neuron. The NGF/TrkA complex is subsequently trafficked back to the neuron's
4905:
4595:
4200:
3917:
705:
2386:– 'New Clues to Neurological Diseases Discovered: Findings could lead to new treatments, two studies suggest', Steven Reinberg,
5005:
3185:
2868:
2377:
5583:
5533:
5504:
5451:
3938:
3805:
2383:
1785:"The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death"
1767:
92:
1455:
164:
5262:
5258:
5254:
5250:
2803:
2787:
1588:
Pediaditakis I, Iliopoulos I, Theologidis I, Delivanoglou N, Margioris AN, Charalampopoulos I, Gravanis A (January 2015).
3531:
3450:
3317:
3234:
727:
receptors in the absence of neurotrophins can lead to apoptosis, but the mechanism is poorly understood. The addition of
5246:
2656:
2431:
1536:"Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis"
933:
4935:
4054:
3614:
3225:
2476:
1115:
759:
674:
tail which when cleaved activates an apoptotic pathway. The binding of a proNT (proNGF or proBDNF) to p75NTR and its
435:
268:
2883:
2827:
2818:
1244:
Bradshaw RA, Blundell TL, Lapatto R, McDonald NQ, Murray-Rust J (February 1993). "Nerve growth factor revisited".
853:
located in the CNS. The viability of these mice was moderate. The NT-4-knockout mice had moderate losses of their
5457:
202:. Neurotrophic factors are secreted by target tissue and act by preventing the associated neuron from initiating
2289:
Lessmann V, Gottmann K, Malcangio M (April 2003). "Neurotrophin secretion: current facts and future prospects".
5645:
5544:
5520:
4660:
4216:
4079:
1892:
Nikoletopoulou V, Lickert H, Frade JM, Rencurel C, Giallonardo P, Zhang L, Bibel M, Barde YA (September 2010).
1106:
Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 8: Atypical
Neurotransmitters". In Sydor A, Brown RY (eds.).
559:
444:, but also found in the periphery. To be specific, it is a protein that has activity on certain neurons of the
1758:
Squire, Larry R.; Berg, Darwin; Bloom, Floyd E.; du Lac, Sascha; Ghosh, Anirvan; Spitzer, Nicholas C. (2013).
616:
The dimerization of p75NTR when bound to proneurotrophins and sortilin leads to apoptosis via the JNK cascade.
152:
5640:
5510:
2424:
724:
720:
1412:
Harrington AW, Ginty DD (March 2013). "Long-distance retrograde neurotrophic factor signalling in neurons".
5554:
3950:
3832:
3822:
2619:
2235:"Cell biology in neuroscience: Death of developing neurons: new insights and implications for connectivity"
356:
1046:
Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH (November 1998).
4925:
2588:
288:
5539:
3365:
2593:
2416:
838:
403:
402:, is a protein secreted by a neuron's target cell. NGF is critical for the survival and maintenance of
318:
148:
1783:
Bamji SX, Majdan M, Pozniak CD, Belliveau DJ, Aloyz R, Kohn J, Causing CG, Miller FD (February 1998).
5447:
651:
105:
1003:
Allen SJ, Dawbarn D (February 2006). "Clinical relevance of the neurotrophins and their receptors".
3631:
3547:
3466:
3333:
3250:
2405:
2181:"Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival"
1893:
1090:
795:
686:
625:
543:
246:
410:
neurons. NGF is released from the target cells, binds to and activates its high affinity receptor
5635:
5231:
2978:
2853:
751:
682:
593:
364:
5515:
5131:
5035:
4655:
4074:
3060:
2698:
2614:
2496:
875:
655:
571:
555:
503:
445:
322:
284:
5589:
3786:
3070:
2709:
885:
794:
input. Neurotrophins in the CNS have also been shown to play a more important role in neural
632:
5529:
4915:
3847:
3796:
2455:
1908:
1210:
1201:
Wistow G, Piatigorsky J (June 1987). "Recruitment of enzymes as lens structural proteins".
830:
199:
131:
1154:"Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain"
440:
Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor found originally in the
8:
4670:
4084:
2471:
2401:
1456:
https://scholar.google.com/scholar?cluster=11830727319998892361&hl=en&as_sdt=0,10
1086:
846:
834:
736:
728:
393:
314:
264:
255:
1912:
1381:
1356:
1214:
960:
Philosophical
Transactions of the Royal Society of London. Series B, Biological Sciences
317:(NGF or beta-NGF), a vertebrate protein that stimulates division and differentiation of
4348:
2701:
2357:
2314:
2259:
2234:
2205:
2196:
2180:
2161:
2113:
2088:
2045:
2020:
1991:
1966:
1942:
1874:
1809:
1784:
1655:
1562:
1535:
1437:
1394:
1169:
1028:
980:
955:
819:
640:
481:
2302:
1178:
1153:
539:
Neurotrophin-4 (NT-4) is a neurotrophic factor that signals predominantly through the
4975:
2349:
2306:
2264:
2210:
2153:
2118:
2050:
1996:
1946:
1934:
1866:
1814:
1763:
1647:
1611:
1567:
1516:
1429:
1386:
1337:
1332:
1315:
1296:
1292:
1261:
1257:
1226:
1183:
1111:
1069:
1020:
985:
925:
735:(for TrkC) prevents this apoptosis. For this reason TrkA and TrkC are referred to as
704:. The transactivation of c-Jun results in the transcription of pro-apoptotic factors
663:
139:
97:
2667:
2361:
2318:
2165:
1878:
1659:
1441:
1398:
61:
5393:
4525:
2341:
2298:
2254:
2246:
2200:
2192:
2145:
2108:
2104:
2100:
2040:
2032:
1986:
1978:
1924:
1916:
1858:
1804:
1796:
1639:
1601:
1557:
1547:
1506:
1421:
1376:
1368:
1327:
1288:
1253:
1218:
1173:
1165:
1059:
1032:
1012:
975:
967:
917:
804:
791:
787:
767:
207:
127:
5621:
1894:"Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not"
1552:
845:
of these mice was poor. The BDNF-knockout mice had losses of a majority of their
698:
694:
510:. NT-3 is the third neurotrophic factor to be characterized, after NGF and BDNF.
465:
376:
73:
1281:
Biochimica et
Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
612:
206:– allowing the neurons to survive. Neurotrophins also induce differentiation of
5579:
5500:
5442:
5136:
4985:
4980:
4094:
4089:
2735:
2725:
2720:
2481:
2451:
2447:
921:
747:
732:
601:
586:
534:
497:
423:
415:
407:
276:
272:
233:. Neurotrophins are chemicals that help to stimulate and control neurogenesis.
191:
2345:
1643:
1372:
842:
5629:
5273:
5186:
5115:
5085:
5020:
4930:
4884:
4760:
4690:
4635:
4624:
4109:
3817:
3500:
3405:
3297:
2598:
2463:
1628:
1587:
810:
755:
659:
525:
have loss of proprioceptive and subsets of mechanoreceptive sensory neurons.
399:
1222:
5599:
5569:
5308:
5298:
5191:
5090:
4945:
4765:
4700:
4615:
4119:
3922:
3761:
3756:
3676:
3626:
3440:
3194:
3175:
3154:
3125:
2848:
2843:
2644:
2639:
2634:
2629:
2353:
2310:
2268:
2157:
2122:
2054:
2000:
1938:
1870:
1651:
1615:
1571:
1520:
1433:
1390:
1024:
989:
971:
929:
863:
850:
775:
690:
667:
582:
372:
338:
330:
292:
230:
2250:
2214:
1818:
1800:
1341:
1300:
1265:
1230:
1187:
1073:
101:
5559:
5525:
5423:
5413:
5408:
5398:
5348:
5171:
5070:
4831:
4745:
4675:
4570:
4333:
4298:
4248:
4211:
4147:
4029:
3960:
3912:
3902:
3897:
3892:
3776:
3771:
3766:
3144:
3055:
3045:
3013:
3008:
3003:
2998:
2988:
2948:
2913:
2036:
1606:
1533:
826:
783:
763:
678:
461:
222:
20:
2446:
1920:
1511:
1494:
1316:"Amino acid sequences of nerve growth factors derived from cobra venoms"
829:. It was found that NGF-knockout mice had losses of a majority of their
681:(which binds the pro-domain of proNTs) causes a p75NTR-dependent signal
5378:
5343:
5338:
5328:
5318:
5236:
5025:
5000:
4990:
4836:
4790:
4650:
4476:
4445:
4414:
4383:
4328:
4303:
4283:
4268:
4258:
4152:
4069:
3862:
3842:
3741:
3686:
3681:
3505:
3410:
3395:
3190:
3149:
3121:
3090:
3050:
2953:
2908:
2903:
2878:
2873:
2863:
2776:
2770:
2760:
2624:
1982:
1967:"Understanding proneurotrophin actions: Recent advances and challenges"
1929:
1590:"Dehydroepiandrosterone: an ancestral ligand of neurotrophin receptors"
1016:
779:
740:
709:
675:
644:
565:
469:
342:
195:
85:
1045:
295:. Neurotrophin-6 and neurotrophin-7 also exist, but are only found in
5403:
5373:
5368:
5363:
5358:
5353:
5333:
5323:
5313:
5303:
4995:
4955:
4851:
4826:
4585:
4580:
4575:
4565:
4560:
4555:
4545:
4466:
4404:
4338:
4318:
4313:
4308:
4293:
4288:
4278:
4273:
4167:
4142:
3907:
3827:
3746:
3691:
3581:
3520:
3510:
3415:
3302:
3100:
3095:
3085:
2993:
2983:
2968:
2943:
2938:
2928:
2923:
2918:
2572:
2567:
2562:
2557:
2552:
2547:
2542:
2537:
2519:
2514:
822:
671:
629:
597:
473:
426:
is thought to be involved in the long-distance signaling of neurons.
296:
226:
203:
2149:
1862:
1846:
1425:
345:
of glycosylated p75 (NRT), forming a symmetrical crystal structure.
5617:
5574:
5293:
4950:
4550:
4540:
4520:
4263:
4253:
3600:
3080:
3023:
2933:
2893:
1589:
1108:
800:
771:
457:
68:
4455:
4424:
4393:
4357:
1891:
1152:
Hofer M, Pagliusi SR, Hohn A, Leibrock J, Barde YA (August 1990).
1110:(2nd ed.). New York: McGraw-Hill Medical. pp. 199, 215.
790:) more factors determine cell fate, including neural activity and
333:
receptors that can bind to neurotrophins. These two proteins are
263:
is more generally reserved for four structurally related factors:
221:
are formed prenatally, parts of the adult brain (for example, the
5549:
4970:
4435:
3837:
2798:
2509:
1064:
1047:
906:"Dissecting the diverse actions of pro- and mature neurotrophins"
589:
575:
568:
507:
449:
184:
180:
80:
604:, eventually being superseded by the polypeptide neurotrophins.
5462:
5126:
5015:
4940:
4645:
4640:
4064:
4059:
4013:
4009:
4005:
4001:
3997:
3993:
3989:
3641:
3180:
2858:
2529:
2178:
1243:
880:
815:
621:
453:
321:
and embryonic sensory neurons. NGF is mostly found outside the
159:
1314:
Inoue S, Oda T, Koyama J, Ikeda K, Hayashi K (February 1991).
5494:
5490:
5486:
5482:
5478:
5474:
5470:
5466:
5181:
5080:
4755:
4695:
4509:
4232:
4228:
4224:
4220:
3711:
3575:
3494:
3490:
3389:
3385:
3381:
3377:
3286:
3282:
3133:
701:
578:
441:
218:
2179:
Yoon SO, Casaccia-Bonnefil P, Carter B, Chao MV (May 1998).
5613:
4965:
3571:
3567:
3563:
3559:
3555:
3551:
3486:
3482:
3478:
3474:
3470:
3373:
3369:
3361:
3357:
3353:
3349:
3345:
3341:
3337:
3278:
3274:
3270:
3266:
3262:
3258:
3254:
3206:
3202:
3198:
3164:
3129:
3110:
2486:
2089:"Neurotrophins: roles in neuronal development and function"
1782:
713:
540:
522:
518:
514:
419:
411:
309:
121:
56:
35:
2232:
1690:
Sanes, Dan H.; Reh, Thomas A.; Harris, William A. (2012).
1134:
Sanes, Dan H.; Reh, Thomas A.; Harris, William A. (2012).
1101:
1099:
2288:
1151:
658:(CNS) the p75NTR-neurotrophin binding activates multiple
337:(NTR), which binds to all neurotrophins, and subtypes of
2233:
Dekkers MP, Nikoletopoulou V, Barde YA (November 2013).
628:, and survival. They also play an important role in the
1278:
1096:
217:
Although the vast majority of neurons in the mammalian
183:
that induce the survival, development, and function of
5612:
This article incorporates text from the public domain
5565:
Pituitary adenylate cyclase-activating peptide (PACAP)
1964:
685:
cascade. The cleaved death domain of p75NTR activates
2697:
1965:
Teng KK, Felice S, Kim T, Hempstead BL (April 2010).
1757:
624:
development neurotrophins play a key role in growth,
225:) retain the ability to grow new neurons from neural
429:
1313:
1105:
758:(i.e. neurotrophins). However, in the CNS (where
5511:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
4369:Glial cell line-derived neurotrophic factor (GDNF)
4022:Cleavage products/derivatives with unknown target:
1357:"Neurotrophin signaling: many exciting surprises!"
546:. It is also known as NT4, NT5, NTF4, and NT-4/5.
283:generally refers to these four neurotrophins, the
2018:
1492:
1200:
5627:
5545:Macrophage-stimulating protein (MSP; HLP, HGFLP)
607:
3186:Heparin-binding EGF-like growth factor (HB-EGF)
2869:Heparin-binding EGF-like growth factor (HB-EGF)
1583:
1581:
1488:
1486:
1484:
1411:
689:(JNK). The activated JNK translocates into the
2086:
1689:
1133:
5597:Additional growth factor receptor modulators:
2683:
2432:
1493:Prough RA, Clark BJ, Klinge CM (April 2016).
1147:
1145:
1048:"Neurogenesis in the adult human hippocampus"
643:is responsible for the loss of a majority of
460:sprouting. In the brain, it is active in the
3951:Insulin-like growth factor-2 (somatomedin A)
3833:Insulin-like growth factor-2 (somatomedin A)
3823:Insulin-like growth factor-1 (somatomedin C)
1622:
1578:
1527:
1481:
1405:
1348:
1002:
956:"Neurotrophin-regulated signalling pathways"
398:Nerve growth factor (NGF), the prototypical
1307:
1272:
1237:
996:
947:
897:
2690:
2676:
2439:
2425:
2331:
2135:
2019:Dhanasekaran DN, Reddy EP (October 2008).
1194:
1142:
1039:
243:United States National Library of Medicine
34:
2404:at the U.S. National Library of Medicine
2258:
2204:
2112:
2044:
1990:
1928:
1847:"The yin and yang of neurotrophin action"
1844:
1808:
1605:
1561:
1551:
1510:
1380:
1354:
1331:
1177:
1089:at the U.S. National Library of Medicine
1063:
979:
953:
903:
521:). Mice born without the ability to make
5555:Migration-stimulating factor (MSF; PRG4)
611:
549:
2884:Transforming growth factor alpha (TGFα)
5628:
5458:Connective tissue growth factor (CTGF)
1753:
1751:
1749:
1747:
1745:
1743:
1741:
1739:
1737:
1735:
1733:
1731:
1729:
1727:
1725:
1723:
1721:
387:
5521:Hepatoma-derived growth factor (HDGF)
2671:
2420:
2284:
2282:
2280:
2278:
2228:
2226:
2224:
2082:
2080:
2078:
2076:
2074:
2072:
2070:
2068:
2066:
2064:
2014:
2012:
2010:
1960:
1958:
1956:
1845:Lu B, Pang PT, Woo NH (August 2005).
1840:
1838:
1836:
1834:
1832:
1830:
1828:
1719:
1717:
1715:
1713:
1711:
1709:
1707:
1705:
1703:
1701:
1685:
1683:
1681:
1679:
1677:
1675:
1673:
1671:
1669:
1762:. Academic Press. pp. 405–435.
1361:Cellular and Molecular Life Sciences
1694:. Academic Press. pp. 173–193.
1460:
1138:. Academic Press. pp. 173–193.
13:
5651:Single-pass transmembrane proteins
2275:
2221:
2197:10.1523/JNEUROSCI.18-09-03273.1998
2061:
2007:
1953:
1885:
1825:
1698:
1666:
1499:Journal of Molecular Endocrinology
1495:"Novel mechanisms for DHEA action"
1468:"Entrez database entry for NT-4/5"
1170:10.1002/j.1460-2075.1990.tb07423.x
585:(DHEA-S), have been identified as
14:
5662:
2371:
1692:Development of the Nervous System
1136:Development of the Nervous System
528:
491:
436:Brain-derived neurotrophic factor
430:Brain-derived neurotrophic factor
269:brain-derived neurotrophic factor
5540:Leukemia inhibitory factor (LIF)
746:In the PNS (where NGF, NT-3 and
4708:Negative allosteric modulators:
2325:
2172:
2129:
2087:Huang EJ, Reichardt LF (2001).
1776:
1448:
1355:Arévalo JC, Wu SH (July 2006).
954:Reichardt LF (September 2006).
650:In the development of both the
5026:Gossypetin (3,5,7,8,3',4'-HHF)
4217:Platelet-derived growth factor
2138:Nature Reviews. Drug Discovery
2105:10.1146/annurev.neuro.24.1.677
1246:Trends in Biochemical Sciences
1127:
1080:
904:Hempstead BL (February 2006).
639:. The PCD which occurs during
592:of the TrkA and p75 with high
560:Dehydroepiandrosterone sulfate
236:
1:
5232:Placental growth factor (PGF)
2303:10.1016/s0301-0082(03)00019-4
2093:Annual Review of Neuroscience
891:
608:Role in programmed cell death
253:may be used as a synonym for
116:Available protein structures:
5516:Glia maturation factor (GMF)
4025:Glypromate (GPE, (1-3)IGF-1)
2021:"JNK signaling in apoptosis"
1851:Nature Reviews. Neuroscience
1553:10.1371/journal.pbio.1001051
1414:Nature Reviews. Neuroscience
1333:10.1016/0014-5793(91)80244-W
1293:10.1016/0167-4838(92)90090-Z
1258:10.1016/0968-0004(93)90052-O
418:. This movement of NGF from
357:Nerve growth factor receptor
348:
7:
2239:The Journal of Cell Biology
2185:The Journal of Neuroscience
1789:The Journal of Cell Biology
869:
302:
289:ciliary neurotrophic factor
10:
5667:
5611:
5448:Colony-stimulating factors
5440:Additional growth factors:
1971:Developmental Neurobiology
922:10.2174/156720506775697061
910:Current Alzheimer Research
762:is mainly secreted in the
754:is determined by a single
553:
532:
495:
433:
391:
354:
190:They belong to a class of
18:
5432:
5219:
5114:
4883:
4796:SNA-120 (pegylated K252a)
4623:
4614:
4594:
4508:
4485:
4454:
4423:
4392:
4356:
4347:
4199:
4042:
3975:
3968:(against IGF-1 and IGF-2)
3937:
3930:(against IGF-1 and IGF-2)
3804:
3795:
3613:
3590:
3530:
3449:
3316:
3233:
3224:
3163:
3109:
3022:
2826:
2817:
2786:
2708:
2607:
2581:
2528:
2495:
2462:
2346:10.1007/S00441-009-0784-Z
1644:10.1126/scisignal.2003387
1373:10.1007/s00018-006-6010-1
839:superior cervical ganglia
652:peripheral nervous system
363:There are two classes of
158:
138:
120:
115:
111:
91:
79:
67:
55:
47:
42:
33:
28:
3632:Hepatocyte growth factor
3191:Neuregulins (heregulins)
3122:Neuregulins (heregulins)
3066:Trastuzumab duocarmazine
2779:(against angiopoietin 2)
2773:(against angiopoietin 3)
2406:Medical Subject Headings
2398:– 'Neurotrophic factors'
2334:Cell and Tissue Research
2291:Progress in Neurobiology
1760:Fundamental Neuroscience
1091:Medical Subject Headings
544:receptor tyrosine kinase
382:
247:medical subject headings
19:Not to be confused with
2979:Depatuxizumab mafodotin
1223:10.1126/science.3589669
855:nodose petrosal ganglia
687:c-Jun N-terminal kinase
5602:(neurotrophin mixture)
5590:Wnt signaling proteins
5271:Allosteric modulators:
4991:Norwogonin (5,7,8-THF)
3211:5 (tomoregulin, TMEFF)
3061:Trastuzumab deruxtecan
2699:Growth factor receptor
2413:– Neurotrophin-3 image
972:10.1098/rstb.2006.1894
876:Neurotrophic electrode
656:central nervous system
617:
572:dehydroepiandrosterone
556:Dehydroepiandrosterone
504:central nervous system
446:central nervous system
323:central nervous system
285:GDNF family of ligands
5646:Programmed cell death
5530:T-cell growth factors
3787:Telisotuzumab vedotin
3071:Trastuzumab emtansine
2251:10.1083/jcb.201306136
1801:10.1083/jcb.140.4.911
886:Programmed cell death
750:are mainly secreted)
633:programmed cell death
615:
550:DHEA and DHEA sulfate
229:, a process known as
204:programmed cell death
5641:Neurotrophic factors
4115:EVT-901 (SAR-127963)
3848:Mecasermin rinfabate
2456:Neurotrophic factors
2037:10.1038/onc.2008.301
1607:10.1210/en.2014-1596
796:cell differentiation
737:dependence receptors
291:(CNTF), among other
200:neurotrophic factors
1921:10.1038/nature09336
1913:2010Natur.467...59N
1512:10.1530/JME-16-0013
1215:1987Sci...236.1554W
1209:(4808): 1554–1556.
966:(1473): 1545–1564.
831:dorsal root ganglia
394:Nerve growth factor
388:Nerve growth factor
367:for neurotrophins:
315:nerve growth factor
281:neurotrophic factor
265:nerve growth factor
256:neurotrophic factor
5281:Kinase inhibitors:
5144:Kinase inhibitors:
5043:Kinase inhibitors:
4718:Kinase inhibitors:
4533:Kinase inhibitors:
4493:Kinase inhibitors:
4474:Kinase inhibitors:
4443:Kinase inhibitors:
4412:Kinase inhibitors:
4381:Kinase inhibitors:
4241:Kinase inhibitors:
3855:Kinase inhibitors:
3649:Kinase inhibitors:
3438:Kinase inhibitors:
3431:Aprutumab ixadotin
3078:Kinase inhibitors:
2891:Kinase inhibitors:
2748:Kinase inhibitors:
1983:10.1002/dneu.20768
1017:10.1042/CS20050161
864:spinal moroneurons
851:facial motoneurons
847:vestibular ganglia
835:trigeminal ganglia
719:The expression of
618:
482:neural development
16:Family of proteins
5609:
5608:
5215:
5214:
4976:N-Acetylserotonin
4875:ReN-1820 (TrkAd5)
4504:
4503:
4038:
4037:
3983:Binding proteins:
3642:Dihexa (PNB-0408)
3609:
3608:
3220:
3219:
3134:6 (neuroglycan C)
2854:EGF (urogastrone)
2832:
2665:
2664:
2031:(48): 6245–6251.
1769:978-0-12-385870-2
1632:Science Signaling
1367:(13): 1523–1537.
1058:(11): 1313–1317.
641:brain development
279:(NT-4). The term
241:According to the
174:
173:
170:
169:
165:structure summary
5658:
5421:Decoy receptors:
5394:Alacizumab pegol
4872:Decoy receptors:
4621:
4620:
4526:Stem cell factor
4467:Persephin (PSPN)
4405:Neurturin (NRTN)
4354:
4353:
4191:LEVI-04 (p75-Fc)
4188:Decoy receptors:
3802:
3801:
3231:
3230:
2830:
2824:
2823:
2692:
2685:
2678:
2669:
2668:
2441:
2434:
2427:
2418:
2417:
2366:
2365:
2329:
2323:
2322:
2286:
2273:
2272:
2262:
2230:
2219:
2218:
2208:
2191:(9): 3273–3281.
2176:
2170:
2169:
2133:
2127:
2126:
2116:
2084:
2059:
2058:
2048:
2016:
2005:
2004:
1994:
1962:
1951:
1950:
1932:
1898:
1889:
1883:
1882:
1842:
1823:
1822:
1812:
1780:
1774:
1773:
1755:
1696:
1695:
1687:
1664:
1663:
1626:
1620:
1619:
1609:
1585:
1576:
1575:
1565:
1555:
1531:
1525:
1524:
1514:
1490:
1479:
1478:
1476:
1475:
1464:
1458:
1452:
1446:
1445:
1409:
1403:
1402:
1384:
1352:
1346:
1345:
1335:
1311:
1305:
1304:
1276:
1270:
1269:
1241:
1235:
1234:
1198:
1192:
1191:
1181:
1164:(8): 2459–2464.
1158:The EMBO Journal
1149:
1140:
1139:
1131:
1125:
1124:
1103:
1094:
1084:
1078:
1077:
1067:
1043:
1037:
1036:
1005:Clinical Science
1000:
994:
993:
983:
951:
945:
944:
942:
941:
932:. Archived from
901:
860:cochlear ganglia
805:substantia nigra
792:neurotransmitter
768:substantia nigra
377:Tyrosine kinases
208:progenitor cells
179:are a family of
113:
112:
38:
26:
25:
5666:
5665:
5661:
5660:
5659:
5657:
5656:
5655:
5626:
5625:
5624:
5610:
5605:
5550:Midkine (NEGF2)
5428:
5211:
5110:
4879:
4817:ABT-110 (PG110)
4610:
4590:
4500:
4481:
4450:
4419:
4388:
4343:
4195:
4133:ABT-110 (PG110)
4034:
3971:
3933:
3791:
3605:
3586:
3526:
3523:(against FGF23)
3445:
3312:
3216:
3159:
3105:
3018:
2829:
2813:
2782:
2704:
2696:
2666:
2661:
2603:
2577:
2524:
2491:
2458:
2445:
2374:
2369:
2330:
2326:
2287:
2276:
2231:
2222:
2177:
2173:
2150:10.1038/nrd4024
2134:
2130:
2085:
2062:
2017:
2008:
1963:
1954:
1907:(7311): 59–63.
1896:
1890:
1886:
1863:10.1038/nrn1726
1843:
1826:
1781:
1777:
1770:
1756:
1699:
1688:
1667:
1627:
1623:
1586:
1579:
1546:(4): e1001051.
1532:
1528:
1505:(3): R139–155.
1491:
1482:
1473:
1471:
1466:
1465:
1461:
1453:
1449:
1426:10.1038/nrn3253
1410:
1406:
1353:
1349:
1312:
1308:
1277:
1273:
1242:
1238:
1199:
1195:
1150:
1143:
1132:
1128:
1118:
1104:
1097:
1085:
1081:
1052:Nature Medicine
1044:
1040:
1001:
997:
952:
948:
939:
937:
902:
898:
894:
872:
626:differentiation
610:
574:(DHEA) and its
562:
554:Main articles:
552:
537:
531:
500:
494:
438:
432:
396:
390:
385:
359:
351:
305:
259:, but the term
239:
24:
17:
12:
11:
5:
5664:
5654:
5653:
5648:
5643:
5638:
5636:Neurochemistry
5607:
5606:
5604:
5603:
5593:
5592:
5587:
5580:Thrombopoietin
5577:
5572:
5567:
5562:
5557:
5552:
5547:
5542:
5537:
5523:
5518:
5513:
5508:
5501:Erythropoietin
5498:
5460:
5455:
5445:
5443:Adrenomedullin
5436:
5434:
5430:
5429:
5427:
5426:
5417:
5416:
5411:
5406:
5401:
5396:
5387:
5386:
5381:
5376:
5371:
5366:
5361:
5356:
5351:
5346:
5341:
5336:
5331:
5326:
5321:
5316:
5311:
5306:
5301:
5296:
5291:
5286:
5277:
5276:
5267:
5266:
5244:
5239:
5234:
5225:
5223:
5217:
5216:
5213:
5212:
5210:
5209:
5204:
5199:
5194:
5189:
5184:
5179:
5174:
5169:
5164:
5159:
5154:
5149:
5140:
5139:
5134:
5129:
5120:
5118:
5112:
5111:
5109:
5108:
5103:
5098:
5093:
5088:
5083:
5078:
5073:
5068:
5063:
5058:
5053:
5048:
5039:
5038:
5029:
5028:
5023:
5018:
5009:
5008:
5003:
4998:
4993:
4988:
4983:
4978:
4973:
4968:
4963:
4958:
4953:
4948:
4943:
4938:
4933:
4928:
4923:
4918:
4913:
4908:
4906:4'-DMA-7,8-DHF
4903:
4898:
4889:
4887:
4881:
4880:
4878:
4877:
4868:
4867:
4855:
4854:
4849:
4844:
4839:
4834:
4829:
4824:
4819:
4800:
4799:
4793:
4788:
4783:
4778:
4773:
4768:
4763:
4758:
4753:
4748:
4743:
4738:
4733:
4728:
4723:
4714:
4713:
4704:
4703:
4698:
4693:
4688:
4679:
4678:
4673:
4668:
4666:Gambogic amide
4663:
4658:
4653:
4648:
4643:
4638:
4629:
4627:
4618:
4612:
4611:
4609:
4608:
4600:
4598:
4592:
4591:
4589:
4588:
4583:
4578:
4573:
4568:
4563:
4558:
4553:
4548:
4543:
4538:
4529:
4528:
4523:
4514:
4512:
4506:
4505:
4502:
4501:
4499:
4498:
4489:
4487:
4483:
4482:
4480:
4479:
4470:
4469:
4460:
4458:
4452:
4451:
4449:
4448:
4439:
4438:
4436:Artemin (ARTN)
4429:
4427:
4421:
4420:
4418:
4417:
4408:
4407:
4398:
4396:
4390:
4389:
4387:
4386:
4377:
4376:
4371:
4362:
4360:
4351:
4345:
4344:
4342:
4341:
4336:
4331:
4322:
4321:
4316:
4311:
4306:
4301:
4296:
4291:
4286:
4281:
4276:
4271:
4266:
4261:
4256:
4251:
4246:
4237:
4236:
4214:
4205:
4203:
4197:
4196:
4194:
4193:
4184:
4183:
4171:
4170:
4165:
4160:
4155:
4150:
4145:
4140:
4135:
4123:
4122:
4117:
4112:
4107:
4098:
4097:
4092:
4087:
4082:
4077:
4072:
4067:
4062:
4057:
4048:
4046:
4040:
4039:
4036:
4035:
4033:
4032:
4027:
4018:
4017:
3979:
3977:
3973:
3972:
3970:
3969:
3963:
3954:
3953:
3943:
3941:
3935:
3934:
3932:
3931:
3925:
3920:
3915:
3910:
3905:
3900:
3895:
3890:
3881:
3880:
3875:
3870:
3865:
3860:
3851:
3850:
3845:
3840:
3835:
3830:
3825:
3820:
3810:
3808:
3799:
3793:
3792:
3790:
3789:
3784:
3779:
3774:
3769:
3764:
3759:
3750:
3749:
3744:
3739:
3734:
3729:
3724:
3719:
3714:
3709:
3704:
3699:
3694:
3689:
3684:
3679:
3674:
3669:
3664:
3659:
3654:
3645:
3644:
3635:
3634:
3629:
3619:
3617:
3611:
3610:
3607:
3606:
3604:
3603:
3594:
3592:
3588:
3587:
3585:
3584:
3579:
3545:
3536:
3534:
3528:
3527:
3525:
3524:
3514:
3513:
3508:
3503:
3498:
3464:
3455:
3453:
3447:
3446:
3444:
3443:
3434:
3433:
3428:
3419:
3418:
3413:
3408:
3403:
3398:
3393:
3331:
3322:
3320:
3314:
3313:
3311:
3310:
3305:
3300:
3295:
3290:
3248:
3239:
3237:
3228:
3222:
3221:
3218:
3217:
3215:
3214:
3188:
3183:
3178:
3169:
3167:
3161:
3160:
3158:
3157:
3152:
3147:
3138:
3137:
3115:
3113:
3107:
3106:
3104:
3103:
3098:
3093:
3088:
3083:
3074:
3073:
3068:
3063:
3058:
3053:
3048:
3039:
3038:
3028:
3026:
3020:
3019:
3017:
3016:
3011:
3006:
3001:
2996:
2991:
2986:
2981:
2976:
2971:
2962:
2961:
2956:
2951:
2946:
2941:
2936:
2931:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2887:
2886:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2846:
2836:
2834:
2821:
2815:
2814:
2812:
2811:
2806:
2801:
2792:
2790:
2784:
2783:
2781:
2780:
2774:
2764:
2763:
2758:
2753:
2744:
2743:
2741:Angiopoietin 3
2738:
2736:Angiopoietin 2
2729:
2728:
2726:Angiopoietin 4
2723:
2721:Angiopoietin 1
2714:
2712:
2706:
2705:
2695:
2694:
2687:
2680:
2672:
2663:
2662:
2660:
2659:
2654:
2649:
2648:
2647:
2642:
2637:
2632:
2622:
2617:
2611:
2609:
2605:
2604:
2602:
2601:
2596:
2591:
2585:
2583:
2579:
2578:
2576:
2575:
2570:
2565:
2560:
2555:
2550:
2545:
2540:
2534:
2532:
2526:
2525:
2523:
2522:
2517:
2512:
2507:
2501:
2499:
2493:
2492:
2490:
2489:
2484:
2479:
2474:
2468:
2466:
2460:
2459:
2452:Nervous tissue
2448:Cell signaling
2444:
2443:
2436:
2429:
2421:
2415:
2414:
2409:
2399:
2393:
2392:(July 5, 2006)
2381:
2373:
2372:External links
2370:
2368:
2367:
2340:(3): 349–384.
2324:
2297:(5): 341–374.
2274:
2245:(3): 385–393.
2220:
2171:
2144:(7): 507–525.
2128:
2060:
2006:
1977:(5): 350–359.
1952:
1884:
1857:(8): 603–614.
1824:
1795:(4): 911–923.
1775:
1768:
1697:
1665:
1621:
1577:
1526:
1480:
1459:
1447:
1420:(3): 177–187.
1404:
1347:
1306:
1287:(3): 287–292.
1271:
1236:
1193:
1141:
1126:
1116:
1095:
1079:
1038:
1011:(2): 175–191.
995:
946:
895:
893:
890:
889:
888:
883:
878:
871:
868:
814:including the
731:(for TrkA) or
699:transactivates
695:phosphorylates
654:(PNS) and the
609:
606:
602:nervous system
587:small-molecule
551:
548:
535:Neurotrophin-4
533:Main article:
530:
529:Neurotrophin-4
527:
498:Neurotrophin-3
496:Main article:
493:
492:Neurotrophin-3
490:
434:Main article:
431:
428:
392:Main article:
389:
386:
384:
381:
361:
360:
355:Main article:
350:
347:
304:
301:
277:neurotrophin-4
273:neurotrophin-3
238:
235:
192:growth factors
172:
171:
168:
167:
162:
156:
155:
142:
136:
135:
125:
118:
117:
109:
108:
95:
89:
88:
83:
77:
76:
71:
65:
64:
59:
53:
52:
49:
45:
44:
40:
39:
31:
30:
15:
9:
6:
4:
3:
2:
5663:
5652:
5649:
5647:
5644:
5642:
5639:
5637:
5634:
5633:
5631:
5623:
5619:
5615:
5601:
5598:
5595:
5594:
5591:
5588:
5585:
5581:
5578:
5576:
5573:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5535:
5531:
5527:
5524:
5522:
5519:
5517:
5514:
5512:
5509:
5506:
5502:
5499:
5496:
5492:
5488:
5484:
5480:
5476:
5472:
5468:
5464:
5461:
5459:
5456:
5453:
5449:
5446:
5444:
5441:
5438:
5437:
5435:
5431:
5425:
5422:
5419:
5418:
5415:
5412:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5389:
5388:
5385:
5382:
5380:
5377:
5375:
5372:
5370:
5367:
5365:
5362:
5360:
5357:
5355:
5352:
5350:
5347:
5345:
5342:
5340:
5337:
5335:
5332:
5330:
5327:
5325:
5322:
5320:
5317:
5315:
5312:
5310:
5307:
5305:
5302:
5300:
5297:
5295:
5292:
5290:
5287:
5285:
5282:
5279:
5278:
5275:
5274:Cyclotraxin B
5272:
5269:
5268:
5264:
5260:
5256:
5252:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5227:
5226:
5224:
5222:
5218:
5208:
5205:
5203:
5200:
5198:
5195:
5193:
5190:
5188:
5187:Larotrectinib
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5150:
5148:
5145:
5142:
5141:
5138:
5135:
5133:
5130:
5128:
5125:
5122:
5121:
5119:
5117:
5113:
5107:
5104:
5102:
5099:
5097:
5094:
5092:
5089:
5087:
5086:Larotrectinib
5084:
5082:
5079:
5077:
5074:
5072:
5069:
5067:
5064:
5062:
5059:
5057:
5054:
5052:
5049:
5047:
5044:
5041:
5040:
5037:
5034:
5031:
5030:
5027:
5024:
5022:
5021:Cyclotraxin B
5019:
5017:
5014:
5011:
5010:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4952:
4949:
4947:
4944:
4942:
4939:
4937:
4934:
4932:
4931:Amitriptyline
4929:
4927:
4924:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4891:
4890:
4888:
4886:
4882:
4876:
4873:
4870:
4869:
4866:
4863:
4860:
4857:
4856:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4835:
4833:
4830:
4828:
4825:
4823:
4820:
4818:
4815:
4811:
4808:
4807:Against TrkA:
4805:
4802:
4801:
4797:
4794:
4792:
4789:
4787:
4784:
4782:
4779:
4777:
4774:
4772:
4769:
4767:
4764:
4762:
4761:Larotrectinib
4759:
4757:
4754:
4752:
4749:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4727:
4724:
4722:
4719:
4716:
4715:
4712:
4709:
4706:
4705:
4702:
4699:
4697:
4694:
4692:
4691:Dexamethasone
4689:
4687:
4684:
4681:
4680:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4657:
4654:
4652:
4649:
4647:
4644:
4642:
4639:
4637:
4636:Amitriptyline
4634:
4631:
4630:
4628:
4626:
4622:
4619:
4617:
4613:
4606:
4602:
4601:
4599:
4597:
4593:
4587:
4584:
4582:
4579:
4577:
4574:
4572:
4569:
4567:
4564:
4562:
4559:
4557:
4554:
4552:
4549:
4547:
4544:
4542:
4539:
4537:
4534:
4531:
4530:
4527:
4524:
4522:
4519:
4516:
4515:
4513:
4511:
4507:
4497:
4494:
4491:
4490:
4488:
4484:
4478:
4475:
4472:
4471:
4468:
4465:
4462:
4461:
4459:
4457:
4453:
4447:
4444:
4441:
4440:
4437:
4434:
4431:
4430:
4428:
4426:
4422:
4416:
4413:
4410:
4409:
4406:
4403:
4400:
4399:
4397:
4395:
4391:
4385:
4382:
4379:
4378:
4375:
4372:
4370:
4367:
4364:
4363:
4361:
4359:
4355:
4352:
4350:
4346:
4340:
4337:
4335:
4332:
4330:
4327:
4324:
4323:
4320:
4317:
4315:
4312:
4310:
4307:
4305:
4302:
4300:
4297:
4295:
4292:
4290:
4287:
4285:
4282:
4280:
4277:
4275:
4272:
4270:
4267:
4265:
4262:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4239:
4238:
4234:
4230:
4226:
4222:
4218:
4215:
4213:
4210:
4207:
4206:
4204:
4202:
4198:
4192:
4189:
4186:
4185:
4182:
4179:
4176:
4173:
4172:
4169:
4166:
4164:
4161:
4159:
4156:
4154:
4151:
4149:
4146:
4144:
4141:
4139:
4136:
4134:
4131:
4128:
4125:
4124:
4121:
4118:
4116:
4113:
4111:
4110:Dexamethasone
4108:
4106:
4103:
4100:
4099:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4050:
4049:
4047:
4045:
4041:
4031:
4028:
4026:
4023:
4020:
4019:
4015:
4011:
4007:
4003:
3999:
3995:
3991:
3987:
3984:
3981:
3980:
3978:
3974:
3967:
3964:
3962:
3959:
3956:
3955:
3952:
3948:
3945:
3944:
3942:
3940:
3936:
3929:
3926:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3889:
3886:
3883:
3882:
3879:
3876:
3874:
3871:
3869:
3866:
3864:
3861:
3859:
3856:
3853:
3852:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3818:des(1-3)IGF-1
3815:
3812:
3811:
3809:
3807:
3803:
3800:
3798:
3794:
3788:
3785:
3783:
3782:Telisotuzumab
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3752:
3751:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3693:
3690:
3688:
3685:
3683:
3680:
3678:
3675:
3673:
3670:
3668:
3665:
3663:
3660:
3658:
3655:
3653:
3650:
3647:
3646:
3643:
3640:
3639:Potentiators:
3637:
3636:
3633:
3630:
3628:
3624:
3621:
3620:
3618:
3616:
3612:
3602:
3599:
3596:
3595:
3593:
3589:
3583:
3580:
3577:
3573:
3569:
3565:
3561:
3557:
3553:
3549:
3546:
3544:
3541:
3538:
3537:
3535:
3533:
3529:
3522:
3519:
3516:
3515:
3512:
3509:
3507:
3504:
3502:
3501:Selpercatinib
3499:
3496:
3492:
3488:
3484:
3480:
3476:
3472:
3468:
3465:
3463:
3460:
3457:
3456:
3454:
3452:
3448:
3442:
3439:
3436:
3435:
3432:
3429:
3427:
3424:
3421:
3420:
3417:
3414:
3412:
3409:
3407:
3406:Selpercatinib
3404:
3402:
3399:
3397:
3394:
3391:
3387:
3383:
3379:
3375:
3371:
3367:
3363:
3359:
3355:
3351:
3347:
3343:
3339:
3335:
3332:
3330:
3327:
3324:
3323:
3321:
3319:
3315:
3309:
3306:
3304:
3301:
3299:
3298:Selpercatinib
3296:
3294:
3291:
3288:
3284:
3280:
3276:
3272:
3268:
3264:
3260:
3256:
3252:
3249:
3247:
3244:
3241:
3240:
3238:
3236:
3232:
3229:
3227:
3223:
3212:
3208:
3204:
3200:
3196:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3171:
3170:
3168:
3166:
3162:
3156:
3153:
3151:
3148:
3146:
3143:
3140:
3139:
3135:
3131:
3127:
3123:
3120:
3117:
3116:
3114:
3112:
3108:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3076:
3075:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3041:
3040:
3037:
3033:
3030:
3029:
3027:
3025:
3021:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2974:Depatuxizumab
2972:
2970:
2967:
2964:
2963:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2889:
2888:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2841:
2838:
2837:
2835:
2833:
2825:
2822:
2820:
2816:
2810:
2807:
2805:
2802:
2800:
2797:
2794:
2793:
2791:
2789:
2785:
2778:
2775:
2772:
2769:
2766:
2765:
2762:
2759:
2757:
2754:
2752:
2749:
2746:
2745:
2742:
2739:
2737:
2734:
2731:
2730:
2727:
2724:
2722:
2719:
2716:
2715:
2713:
2711:
2707:
2703:
2700:
2693:
2688:
2686:
2681:
2679:
2674:
2673:
2670:
2658:
2655:
2653:
2650:
2646:
2643:
2641:
2638:
2636:
2633:
2631:
2628:
2627:
2626:
2623:
2621:
2618:
2616:
2613:
2612:
2610:
2606:
2600:
2597:
2595:
2592:
2590:
2587:
2586:
2584:
2580:
2574:
2571:
2569:
2566:
2564:
2561:
2559:
2556:
2554:
2551:
2549:
2546:
2544:
2541:
2539:
2536:
2535:
2533:
2531:
2527:
2521:
2518:
2516:
2513:
2511:
2508:
2506:
2503:
2502:
2500:
2498:
2494:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2470:
2469:
2467:
2465:
2464:Neurotrophins
2461:
2457:
2453:
2449:
2442:
2437:
2435:
2430:
2428:
2423:
2422:
2419:
2412:
2410:
2407:
2403:
2402:Neurotrophins
2400:
2397:
2394:
2391:
2390:
2385:
2382:
2379:
2376:
2375:
2363:
2359:
2355:
2351:
2347:
2343:
2339:
2335:
2328:
2320:
2316:
2312:
2308:
2304:
2300:
2296:
2292:
2285:
2283:
2281:
2279:
2270:
2266:
2261:
2256:
2252:
2248:
2244:
2240:
2236:
2229:
2227:
2225:
2216:
2212:
2207:
2202:
2198:
2194:
2190:
2186:
2182:
2175:
2167:
2163:
2159:
2155:
2151:
2147:
2143:
2139:
2132:
2124:
2120:
2115:
2110:
2106:
2102:
2098:
2094:
2090:
2083:
2081:
2079:
2077:
2075:
2073:
2071:
2069:
2067:
2065:
2056:
2052:
2047:
2042:
2038:
2034:
2030:
2026:
2022:
2015:
2013:
2011:
2002:
1998:
1993:
1988:
1984:
1980:
1976:
1972:
1968:
1961:
1959:
1957:
1948:
1944:
1940:
1936:
1931:
1926:
1922:
1918:
1914:
1910:
1906:
1902:
1895:
1888:
1880:
1876:
1872:
1868:
1864:
1860:
1856:
1852:
1848:
1841:
1839:
1837:
1835:
1833:
1831:
1829:
1820:
1816:
1811:
1806:
1802:
1798:
1794:
1790:
1786:
1779:
1771:
1765:
1761:
1754:
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1657:
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1649:
1645:
1641:
1637:
1633:
1625:
1617:
1613:
1608:
1603:
1599:
1595:
1594:Endocrinology
1591:
1584:
1582:
1573:
1569:
1564:
1559:
1554:
1549:
1545:
1541:
1537:
1530:
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1500:
1496:
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1175:
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1167:
1163:
1159:
1155:
1148:
1146:
1137:
1130:
1123:
1119:
1117:9780071481274
1113:
1109:
1102:
1100:
1092:
1088:
1087:Neurotrophins
1083:
1075:
1071:
1066:
1061:
1057:
1053:
1049:
1042:
1034:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
999:
991:
987:
982:
977:
973:
969:
965:
961:
957:
950:
936:on 2009-08-30
935:
931:
927:
923:
919:
915:
911:
907:
900:
896:
887:
884:
882:
879:
877:
874:
873:
867:
865:
861:
856:
852:
848:
844:
840:
836:
832:
828:
824:
821:
817:
812:
811:Gene knockout
808:
806:
802:
797:
793:
789:
785:
781:
777:
773:
769:
765:
761:
757:
756:growth factor
753:
749:
744:
742:
738:
734:
730:
726:
722:
717:
715:
711:
707:
703:
700:
696:
692:
688:
684:
680:
677:
673:
669:
665:
661:
660:intracellular
657:
653:
648:
646:
642:
638:
634:
631:
627:
623:
614:
605:
603:
599:
595:
591:
588:
584:
580:
577:
573:
570:
567:
561:
557:
547:
545:
542:
536:
526:
524:
520:
516:
511:
509:
505:
499:
489:
485:
483:
477:
475:
471:
467:
463:
459:
455:
451:
447:
443:
437:
427:
425:
421:
417:
413:
409:
405:
401:
400:growth factor
395:
380:
378:
374:
370:
366:
358:
353:
352:
346:
344:
340:
336:
332:
326:
324:
320:
316:
311:
300:
298:
294:
290:
286:
282:
278:
274:
270:
266:
262:
258:
257:
252:
248:
244:
234:
232:
228:
224:
220:
215:
213:
209:
205:
201:
197:
193:
188:
186:
182:
178:
177:Neurotrophins
166:
163:
161:
157:
154:
150:
146:
143:
141:
137:
133:
129:
126:
123:
119:
114:
110:
107:
103:
99:
96:
94:
90:
87:
84:
82:
78:
75:
72:
70:
66:
63:
60:
58:
54:
50:
46:
41:
37:
32:
27:
22:
5600:Cerebrolysin
5596:
5570:Pleiotrophin
5526:Interleukins
5439:
5420:
5390:
5309:Fruquintinib
5299:Cabozantinib
5280:
5270:
5228:
5192:Lestaurtinib
5143:
5123:
5091:Lestaurtinib
5042:
5032:
5013:Antagonists:
5012:
4946:Deoxygedunin
4901:3,7,8,2'-THF
4892:
4871:
4862:Against NGF:
4861:
4858:
4814:Against NGF:
4813:
4806:
4803:
4766:Lestaurtinib
4717:
4707:
4701:Testosterone
4683:Antagonists:
4682:
4632:
4532:
4517:
4492:
4473:
4463:
4442:
4432:
4411:
4401:
4380:
4365:
4325:
4240:
4208:
4187:
4178:Against NGF:
4177:
4174:
4130:Against NGF:
4129:
4126:
4120:Testosterone
4102:Antagonists:
4101:
4051:
4021:
3982:
3957:
3946:
3923:Teprotumumab
3884:
3854:
3813:
3762:Ficlatuzumab
3757:Emibetuzumab
3753:
3707:JNJ-38877605
3677:Cabozantinib
3648:
3638:
3627:Fosgonimeton
3622:
3597:
3539:
3517:
3458:
3441:Infigratinib
3437:
3422:
3325:
3242:
3176:Betacellulin
3172:
3155:Seribantumab
3141:
3118:
3077:
3042:
3036:Unknown/none
3035:
3031:
2965:
2890:
2849:Betacellulin
2844:Amphiregulin
2839:
2831:(ErbB1/HER1)
2795:
2767:
2747:
2733:Antagonists:
2732:
2717:
2710:Angiopoietin
2387:
2337:
2333:
2327:
2294:
2290:
2242:
2238:
2188:
2184:
2174:
2141:
2137:
2131:
2096:
2092:
2028:
2024:
1974:
1970:
1904:
1900:
1887:
1854:
1850:
1792:
1788:
1778:
1759:
1691:
1638:(246): pt8.
1635:
1631:
1624:
1600:(1): 16–23.
1597:
1593:
1543:
1540:PLOS Biology
1539:
1529:
1502:
1498:
1472:. Retrieved
1462:
1450:
1417:
1413:
1407:
1364:
1360:
1350:
1326:(1): 38–40.
1323:
1320:FEBS Letters
1319:
1309:
1284:
1280:
1274:
1252:(2): 48–52.
1249:
1245:
1239:
1206:
1202:
1196:
1161:
1157:
1135:
1129:
1121:
1107:
1082:
1065:10.1038/3305
1055:
1051:
1041:
1008:
1004:
998:
963:
959:
949:
938:. Retrieved
934:the original
916:(1): 19–24.
913:
909:
899:
809:
776:hypothalamus
745:
718:
683:transduction
668:death domain
664:pro-peptides
649:
619:
583:DHEA sulfate
563:
538:
512:
501:
486:
478:
472:, and basal
439:
397:
373:"Trk" family
362:
331:glycosylated
327:
306:
293:biomolecules
280:
275:(NT-3), and
261:neurotrophin
260:
254:
251:neurotrophin
250:
240:
231:neurogenesis
216:
211:
189:
176:
175:
29:Neurotrophin
5560:Oncomodulin
5424:Aflibercept
5414:Ranibizumab
5409:Ramucirumab
5399:Bevacizumab
5391:Antibodies:
5349:Regorafenib
5289:Altiratinib
5202:ONO-5390556
5172:Entrectinib
5147:Altiratinib
5101:ONO-5390556
5071:Entrectinib
5046:Altiratinib
4832:Frunevetmab
4804:Antibodies:
4781:ONO-5390556
4746:Entrectinib
4721:Altiratinib
4676:Tavilermide
4571:Quizartinib
4510:SCF (c-Kit)
4334:Ramucirumab
4326:Antibodies:
4299:Quizartinib
4249:Avapritinib
4212:Becaplermin
4148:Frunevetmab
4127:Antibodies:
4030:Trofinetide
3961:Dusigitumab
3958:Antibodies:
3913:Robatumumab
3903:Figitumumab
3898:Dalotuzumab
3893:Cixutumumab
3885:Antibodies:
3777:Rilotumumab
3772:Onartuzumab
3767:Flanvotumab
3754:Antibodies:
3722:PF-04217903
3652:Altiratinib
3615:HGF (c-Met)
3518:Antibodies:
3423:Antibodies:
3145:Duligotumab
3142:Antibodies:
3056:Trastuzumab
3046:Ertumaxomab
3043:Antibodies:
3014:Zalutumumab
3009:Panitumumab
3004:Nimotuzumab
2999:Necitumumab
2989:Imgatuzumab
2966:Antibodies:
2949:Osimertinib
2914:Dacomitinib
2809:Dapiclermin
2768:Antibodies:
2751:Altiratinib
2625:Neuregulins
2582:CNTF family
2497:GDNF family
2396:Helsinki.fi
2384:Dr.Koop.com
2099:: 677–736.
1930:10261/27437
827:spinal cord
820:cholinergic
784:hippocampus
764:spinal cord
741:lipid rafts
693:, where it
679:co-receptor
672:cytoplasmic
645:neuroblasts
462:hippocampus
404:sympathetic
379:receptors.
319:sympathetic
249:, the term
237:Terminology
223:hippocampus
43:Identifiers
21:Neurotropic
5630:Categories
5379:Vandetanib
5344:Rebastinib
5339:Pegaptanib
5329:Nintedanib
5319:Lenvatinib
5284:Agerafenib
5237:Ripretinib
5162:CH-7057288
5061:CH-7057288
4926:7,8,3'-THF
4921:7,8,2'-THF
4847:Ranevetmab
4837:Fulranumab
4791:Rebastinib
4736:CH-7057288
4651:Cenegermin
4536:Agerafenib
4496:Agerafenib
4477:Vandetanib
4446:Vandetanib
4415:Vandetanib
4384:Vandetanib
4329:Olaratumab
4304:Ripretinib
4284:Nintedanib
4269:Lenvatinib
4259:Crenolanib
4244:Agerafenib
4163:Ranevetmab
4153:Fulranumab
4070:Cenegermin
4044:LNGF (p75)
3966:Xentuzumab
3928:Xentuzumab
3873:NVP-AEW541
3868:NVP-ADW742
3863:Linsitinib
3858:BMS-754807
3843:Mecasermin
3742:Tivantinib
3732:PHA-665752
3727:PF-2341066
3697:Golvatinib
3687:Crizotinib
3682:Capmatinib
3672:BMS-777607
3667:Amuvatinib
3543:Ersofermin
3506:Sprifermin
3462:Ersofermin
3411:Sprifermin
3401:Repifermin
3396:Palifermin
3329:Ersofermin
3308:Velafermin
3293:Repifermin
3246:Ersofermin
3165:ErbB4/HER4
3150:Patritumab
3111:ErbB3/HER3
3091:Mubritinib
3051:Pertuzumab
3024:ErbB2/HER2
2954:Vandetanib
2909:Canertinib
2904:Brigatinib
2899:Agerafenib
2879:Nepidermin
2874:Murodermin
2864:Epiregulin
2819:EGF (ErbB)
2777:Nesvacumab
2771:Evinacumab
2761:Rebastinib
2702:modulators
2378:DevBio.com
1474:2007-05-07
940:2020-04-16
892:References
780:cerebellum
566:endogenous
470:cerebellum
343:ectodomain
227:stem cells
128:structures
5622:IPR002072
5404:Icrucumab
5384:WHI-P 154
5374:Tivozanib
5369:Toceranib
5364:Sunitinib
5359:Sorafenib
5354:Semaxanib
5334:Pazopanib
5324:Motesanib
5314:Lapatinib
5304:Cediranib
5242:Telbermin
5229:Agonists:
5177:GZ-389988
5157:CE-245677
5124:Agonists:
5076:GZ-389988
5056:CE-245677
4956:Diosmetin
4893:Agonists:
4859:Aptamers:
4852:Tanezumab
4827:Fasinumab
4771:Milciclib
4751:GZ-389988
4731:CE-245677
4633:Agonists:
4586:Toceranib
4581:Sunitinib
4576:Sorafenib
4566:Pazopanib
4561:Nilotinib
4556:Masitinib
4546:Dasatinib
4518:Agonists:
4464:Agonists:
4433:Agonists:
4402:Agonists:
4374:Liatermin
4366:Agonists:
4349:RET (GFL)
4339:Tovetumab
4319:Toceranib
4314:Sorafenib
4309:Sunitinib
4294:Radotinib
4289:Pazopanib
4279:Motesanib
4274:Masitinib
4209:Agonists:
4175:Aptamers:
4168:Tanezumab
4143:Fasinumab
4052:Agonists:
3908:Ganitumab
3828:IGF-1 LR3
3747:Volitinib
3702:INCB28060
3692:Foretinib
3598:Agonists:
3582:Trafermin
3540:Agonists:
3521:Burosumab
3511:Trafermin
3459:Agonists:
3426:Aprutumab
3416:Trafermin
3378:10 (KGF2)
3326:Agonists:
3303:Trafermin
3283:10 (KGF2)
3243:Agonists:
3173:Agonists:
3119:Agonists:
3101:Tucatinib
3096:Neratinib
3086:Lapatinib
2994:Matuzumab
2984:Futuximab
2969:Cetuximab
2959:WHI-P 154
2944:Neratinib
2939:Lapatinib
2929:Grandinin
2924:Gefitinib
2919:Erlotinib
2796:Agonists:
2756:CE-245677
2718:Agonists:
2520:Persephin
2515:Neurturin
2389:HealthDay
1947:205222117
843:viability
823:brainstem
752:cell fate
630:apoptotic
598:evolution
474:forebrain
458:dendritic
416:cell body
365:receptors
349:Receptors
297:zebrafish
214:neurons.
86:PDOC00221
74:IPR002072
5618:InterPro
5586:instead)
5575:Renalase
5536:instead)
5507:instead)
5454:instead)
5294:Axitinib
5263:D (FIGF)
5207:PLX-7486
5197:ONO-4474
5152:AZD-6918
5106:PLX-7486
5096:ONO-4474
5051:AZD-6918
5033:Ligands:
4951:Deprenyl
4911:7,3'-DHF
4842:MEDI-578
4822:ASP-6294
4786:PLX-7486
4776:ONO-4474
4726:AZD-6918
4686:ALE-0540
4607:instead.
4551:Imatinib
4541:Axitinib
4521:Ancestim
4486:Unsorted
4264:Imatinib
4254:Axitinib
4158:MEDI-578
4138:ASP-6294
4105:ALE-0540
3947:Agonists
3888:AVE-1642
3814:Agonists
3737:SU-11274
3623:Agonists
3601:FGF15/19
3591:Unsorted
3556:2 (bFGF)
3475:2 (bFGF)
3342:2 (bFGF)
3259:2 (bFGF)
3081:Afatinib
3032:Agonists
2934:Icotinib
2894:Afatinib
2840:Agonists
2362:20325630
2354:19387688
2319:16624509
2311:12787574
2269:24217616
2166:33597483
2158:23977697
2123:11520916
2055:18931691
2025:Oncogene
2001:20186707
1939:20811452
1879:15915753
1871:16062169
1660:26914550
1652:23074265
1616:25330101
1572:21541365
1521:26908835
1442:29211700
1434:23422909
1399:23869093
1391:16699811
1382:11135985
1025:16411894
990:16939974
930:16472198
870:See also
825:and the
801:thalamus
772:amygdala
676:sortilin
594:affinity
590:agonists
569:steroids
508:synapses
452:through
450:synapses
371:and the
303:Function
271:(BDNF),
196:secreted
181:proteins
145:RCSB PDB
69:InterPro
5463:Ephrins
5167:DS-6051
5066:DS-6051
4971:LM22A-4
4961:DMAQ-B1
4916:7,8-DHF
4896:3,7-DHF
4865:RBM-004
4810:GBR-900
4741:DS-6051
4711:VM-902A
4181:RBM-004
3878:OSl-906
3838:Insulin
3717:MK-2461
3662:AMG-458
2799:Axokine
2530:Ephrins
2510:Artemin
2260:3824005
2215:9547236
2206:6792655
2114:2758233
2046:3063296
1992:3063094
1909:Bibcode
1819:9472042
1810:2141754
1563:3082517
1342:1995338
1301:1477101
1266:8488558
1231:3589669
1211:Bibcode
1203:Science
1188:2369898
1074:9809557
1033:9507693
981:1664664
833:(DRG),
691:nucleus
670:on its
620:During
600:of the
576:sulfate
422:tip to
408:sensory
267:(NGF),
185:neurons
81:PROSITE
62:PF00243
5433:Others
5127:BNN-20
5016:ANA-12
4941:BNN-20
4661:DHEA-S
4646:BNN-27
4641:BNN-20
4080:DHEA-S
4065:BNN-27
4060:BNN-20
3976:Others
3181:Epigen
2859:Epigen
2408:(MeSH)
2360:
2352:
2317:
2309:
2267:
2257:
2213:
2203:
2164:
2156:
2121:
2111:
2053:
2043:
1999:
1989:
1945:
1937:
1901:Nature
1877:
1869:
1817:
1807:
1766:
1658:
1650:
1614:
1570:
1560:
1519:
1470:. NCBI
1440:
1432:
1397:
1389:
1379:
1340:
1299:
1264:
1229:
1186:
1179:552273
1176:
1114:
1093:(MeSH)
1072:
1031:
1023:
988:
978:
928:
881:Neuron
841:. The
816:retina
788:cortex
637:p75NTR
622:neuron
466:cortex
454:axonal
287:, and
160:PDBsum
134:
124:
106:SUPFAM
48:Symbol
5582:(see
5532:(see
5503:(see
5450:(see
5182:K252a
5081:K252a
4756:K252a
4696:FX007
4456:GFRα4
4425:GFRα3
4394:GFRα2
4358:GFRα1
3986:IGFBP
3939:IGF-2
3918:R1507
3806:IGF-1
3712:K252a
3532:FGFR4
3451:FGFR3
3318:FGFR2
3235:FGFR1
2652:PACAP
2620:IGF-1
2608:Other
2358:S2CID
2315:S2CID
2162:S2CID
1943:S2CID
1897:(PDF)
1875:S2CID
1656:S2CID
1438:S2CID
1395:S2CID
1029:S2CID
710:Fas-L
706:TFF-a
702:c-Jun
579:ester
442:brain
383:Types
219:brain
210:, to
102:SCOPe
93:SCOP2
5616:and
5614:Pfam
5584:here
5534:here
5505:here
5452:here
5247:VEGF
5221:VEGF
5137:NT-3
5132:DHEA
5116:TrkC
5036:DHEA
5006:TDP6
4986:NT-4
4981:NT-3
4966:HIOC
4936:BDNF
4885:TrkB
4656:DHEA
4625:TrkA
4605:here
4603:See
4596:TGFβ
4201:PDGF
4095:NT-4
4090:NT-3
4075:DHEA
4055:BDNF
2804:CNTF
2788:CNTF
2657:VEGF
2599:IL-6
2589:CNTF
2505:GDNF
2487:NT-4
2482:NT-3
2477:BDNF
2350:PMID
2307:PMID
2265:PMID
2211:PMID
2154:PMID
2119:PMID
2051:PMID
1997:PMID
1935:PMID
1867:PMID
1815:PMID
1764:ISBN
1648:PMID
1612:PMID
1568:PMID
1517:PMID
1430:PMID
1387:PMID
1338:PMID
1297:PMID
1285:1160
1262:PMID
1227:PMID
1184:PMID
1112:ISBN
1070:PMID
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