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Mpox in the Democratic Republic of the Congo

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161: 1819: 149: 173: 185: 121:(WHO) between 1981 and 1986, identified 338 cases with a human-to-human transmission rate of 28%. Until 1986, 95% of cases worldwide were identified in the DRC. Cases were rare in people over the age of 15-years, and over two-thirds of infections could be traced to animal contact within the rainforests. Initially it was uncommon for a family member to contract the infection if they had a smallpox scar, evidence of prior vaccination. 28: 239:
During 2023, a clade I outbreak of mpox disease in the Democratic Republic of the Congo resulted in 14,626 suspected cases being reported, with 654 associated deaths, making for a case-fatality rate of 4.5%. The outbreak continued into 2024, with 3,576 suspected mpox cases and 265 deaths reported in
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Many cases occur sporadically or in small clusters, but large outbreaks also occur. The risk of human-to-human transmission within households in the DRC was noted to range from 50% to 100% during the 2013 outbreak. The DRC's Bokungu Health Zone saw an increase in cases of 600-fold that year. In 2019
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Between 1996 and 2005, mpox cases appeared to be gradually increasingly in older people, with less than a quarter of cases being traced to rainforest animal contact, and with greater close contact infections. Between January 2001 and December 2004, 2,734 cases of suspected human mpox were reported
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After 2005, the DRC was reporting more than 1,000 suspected cases per year. Between November 2005 and November 2007, 760 laboratory-confirmed human mpox cases were detected; particularly in people living in forested areas, males, age less than 15-years, and no previous smallpox vaccination.
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Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, Osborne JC, Rampling T, Beadsworth MB, Duncan CJ, Dunning J, Fletcher TE, Hunter ER, Jacobs M, Khoo SH, Newsholme W, Porter D, Porter RJ, Ratcliffe L, Schmid ML, Semple MG, Tunbridge AJ, Wingfield T, Price NM (24 May 2022).
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Nolen LD, Osadebe L, Katomba J, Likofata J, Mukadi D, Monroe B, Doty J, Hughes CM, Kabamba J, Malekani J, Bomponda PL, Lokota JI, Balilo MP, Likafi T, Lushima RS, Ilunga BK, Nkawa F, Pukuta E, Karhemere S, Tamfum JJ, Nguete B, Wemakoy EO, McCollum AM, Reynolds MG (June 2016).
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would launch a €45 million response plan including awareness campaigns, medical team deployment and patient care, but not vaccines. Kamba also said that the DRC needed about 3.5 million doses of mpox vaccines, with roughly 215.000 doses set to be donated by
114:. The onset of their rash was on 24 August. That year, the disease was identified in another four children, including three in Liberia who were playmates. At the time, evidence of the virus was found in non-human primates in Liberia and Sierre Leone. 129:
A reemergence of the disease in the DRC in 1996 also saw a large number of reported but not all laboratory confirmed cases, with a high transmission rate and lower fatality rate; leading experts to believe a significant number may have actually been
251:. An estimated 64% of the cases and 85% of fatalities have occurred in children. The outbreak consists of two separate sub-variants of clade I, with one of the sub-variants having a novel mutation, making detection with standard assays unreliable. 892:
Rimoin AW, Mulembakani PM, Johnston SC, Lloyd Smith JO, Kisalu NK, Kinkela TL, Blumberg S, Thomassen HA, Pike BL, Fair JN, Wolfe ND, Shongo RL, Graham BS, Formenty P, Okitolonda E, Hensley LE, Meyer H, Wright LL, Muyembe JJ (14 September 2010).
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Transmission of the virus in the outbreak appears to be primarily through sexual and close familial contact, with cases occurring in areas without a history of mpox, such as
258:, with 43 cases reported in March 2024. By early August the outbreak spread further into central and southern Africa with cases of clade I and clade II strains reported in 1173: 293: 1143: 1331: 1275: 1439: 142:
from the DRC. However, civil war limited surveillance and only 171 clinical specimens were obtained from 136 suspected cases; less than 5% of all reported cases.
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Rimoin AW, Kisalu N, Kebela-Ilunga B, Mukaba T, Wright LL, Formenty P, Wolfe ND, Shongo RL, Tshioko F, Okitolonda E, Muyembe JJ, Ryder R, Meyer H (June 2007).
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the DRC reported 3,794 suspected cases and 73 deaths. In the first nine-months of 2020, it reported over 4,500 suspected cases of mpox, including 171 deaths.
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Hobson G, Adamson J, Adler H, Firth R, Gould S, Houlihan C, Johnson C, Porter D, Rampling T, Ratcliffe L, Russell K, Shankar AG, Wingfield T (August 2021).
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Fenner F, santé Om, Organization WH, Henderson DA, Arita I, Jezek Z, Ladnyi ID (1988). "29. Human monkeypox and other poxvirus infections of man".
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became the first non-African country to report a case of clade I mpox. The next day, on 16 August 2024, a case of mpox was confirmed in Pakistan.
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was detected in a nine-month old child in 1970 in the Democratic Republic of the Congo (then Zaire), two years after it reported its last case of
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communities. A regional surveillance system collects reports of all suspected mpox cases, and where possible, they may be investigated.
1692: 1359: 1303: 1472: 895:"Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo" 1226: 1774: 1624: 1753: 1682: 1165: 1662: 1652: 1647: 1139: 1743: 1720: 1715: 1657: 1639: 1629: 1609: 876: 653: 523: 487: 457: 1823: 1748: 1687: 1672: 1614: 1604: 1556: 1465: 1758: 1596: 1419: 511: 240:
the Democratic Republic of the Congo through the first nine weeks of the year, making for an estimated CFR of 7.4%.
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publicly announced that it would donate 100,000 vaccines to the DRC and other neighbouring African countries.
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is reportable in the DRC, where the disease is endemic, and disease burden remains high. There, the more
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is endemic in western and central Africa, with the overwhelming majority of cases occurring in the
767:"Family cluster of three cases of monkeypox imported from Nigeria to the United Kingdom, May 2021" 1392: 232: 1332:"Mpox en RDC: un plan de riposte de 49 millions de dollars et des doses de vaccin attendues" 1276:"Mpox en RDC: un plan de riposte de 49 millions de dollars et des doses de vaccin attendues" 782: 1431: 906: 8: 910: 65:
Initially mainly animal contact in rainforest, later greater human-to-human transmission
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The WHO declared this a Global Health Emergency on 14 August 2024. The following day,
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Many cases occur sporadically or in small clusters, but large outbreaks also occur.
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Proceedings of the National Academy of Sciences of the United States of America
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Breman JG, Kalisa R, Steniowski MV, Zanotto E, Gromyko AI, Arita I (1980).
808: 711: 693: 430: 412: 328:, and further donations being expected by the United States. On 26 August, 279: 1457: 849: 626: 566: 166:
The US epidemiologic team after having landed at Lodja Airport - DRC 1997
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Hunter's Tropical Medicine and Emerging Infectious Diseases E-Book
27: 1435: 329: 321: 259: 472: 1360:"DR Congo on standby for first vaccines to fight mpox outbreak" 1304:"DR Congo on standby for first vaccines to fight mpox outbreak" 1140:"Deadlier strain of mpox spreads to multiple African countries" 675: 315:, had been affected by the outbreak, while announcing that the 285: 267: 263: 821: 514:. In Ryan ET, Hill DR, Solomon T, Aronson N, Endy TP (eds.). 325: 271: 215: 95:
Ib has seen a rapid rise in infections since September 2023.
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Disease outbreaks in the Democratic Republic of the Congo
1197:"W.H.O. Declares Global Emergency over New Mpox Outbreak" 518:(Tenth ed.). Edinburgh: Elsevier. pp. 272–277. 360:. World Health Organization. 14 June 2024. Archived from 138:
region saw the largest number of cases during 1996–1997.
1420:"Mpox: Germany to give Africa 100,000 doses of vaccine" 1249:"Pakistan registers 1st case of mpox – DW – 08/16/2024" 764: 307:, said in a press conference that all of the country's 254:
The outbreak spread to the neighbouring country of the
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I has been affecting some of the world's poorest and
1010: 509: 443: 482:. World Health Organization. pp. 1287–1319. 1844: 1570: 1079: 1077: 1075: 324:and up to three million doses being donated by 33:Mpox (large lymph node in neck), DRC 1996/1997 731:"Monkeypox – Democratic Republic of the Congo" 725: 723: 721: 538: 1473: 760: 758: 756: 639: 1083: 1072: 815: 671: 669: 667: 665: 21:Mpox in the Democratic Republic of the Congo 1487: 1270: 1268: 959: 737:. World Health Organization. Archived from 718: 437: 389: 387: 385: 383: 381: 379: 1480: 1466: 1194: 1131: 885: 862: 753: 644:. In Mercer A, Schmidt A, Weber O (eds.). 346: 26: 1324: 1047: 1029: 1004: 987: 977: 953: 936: 918: 867:. In Malik YS, Singh RK, Dhama K (eds.). 856: 839: 798: 701: 662: 633: 616: 582: 578: 576: 556: 545:Bulletin of the World Health Organization 510:Sutcliffe CG, Rimone AW, Moss WJ (2020). 505: 503: 501: 499: 420: 354:"Mpox - Democratic Republic of the Congo" 1265: 1110: 966:Tropical Medicine and Infectious Disease 532: 376: 233:Mpox § 2023–2024 Central Africa outbreak 1219: 1158: 960:Brown K, Leggat PA (20 December 2016). 871:. Singapore: Springer. pp. 39–68. 783:10.2807/1560-7917.ES.2021.26.32.2100745 466: 444:Fenner F, Wittek R, Dumbell KR (1988). 1845: 642:"Genus Orthopoxvirus: Monkeypox virus" 573: 496: 1461: 1137: 225: 1442:from the original on 27 August 2024 1412: 1400:from the original on 27 August 2024 1380: 1352: 1207:from the original on 14 August 2024 1146:from the original on 15 August 2024 1119:from the original on 15 August 2024 1088:. University of Minnesota. CIDRAP. 124: 13: 1296: 1176:from the original on 6 August 2024 1092:from the original on 19 March 2024 14: 1869: 1818: 1817: 1170:University of Minnesota | CIDRAP 1084:Van Beusekom M (16 March 2024). 583:Cho CT, Wenner HA (March 1973). 311:, including the capital city of 231:This section is an excerpt from 183: 171: 159: 147: 106:The world's first case of human 86:Democratic Republic of the Congo 74:Democratic Republic of the Congo 1388:"Deutschland spendet Impfstoff" 1241: 1195:Mandavilli A (14 August 2024). 1188: 1104: 1018:The Lancet. Infectious Diseases 195: 539:Arita I, Henderson DA (1976). 452:. Elsevier. pp. 227–267. 190:Educational meeting DRC (1997) 178:Testing of Gambian rats (1997) 101: 1: 1396:(in German). 26 August 2024. 1031:10.1016/S1473-3099(22)00228-6 339: 292:On 19 August 2024, the DRC's 1229:. Al Jazeera. 15 August 2024 1111:Stawiska Z (13 March 2024). 1024:(8): S1473–3099(22)00228–6. 869:Animal-Origin Viral Zoonoses 682:Emerging Infectious Diseases 640:Essbauer S, Meyer H (2007). 476:Smallpox and Its Eradication 401:Emerging Infectious Diseases 7: 1340:(in French). 19 August 2024 1284:(in French). 19 August 2024 154:Mpox outbreak in DRC (1997) 117:Active surveillance by the 10: 1874: 979:10.3390/tropicalmed1010008 824:"Human monkeypox, 1970-79" 298:Samuel-Roger Kamba Mulamba 230: 1813: 1787: 1767: 1734: 1706: 1638: 1595: 1549: 1542: 1516: 1495: 1138:Cohen J (3 August 2024). 601:10.1128/br.37.1.1-18.1973 294:Ministry of Public Health 119:World Health Organization 69: 61: 49: 39: 25: 20: 1800:MVA-BN (Imvanex/Jynneos) 648:. Springer. p. 66. 1534:2023–2024 mpox epidemic 1489:2022–2023 mpox outbreak 1115:. Health Policy Watch. 920:10.1073/pnas.1005769107 828:Bull World Health Organ 589:Bacteriological Reviews 694:10.3201/eid1306.061540 413:10.3201/eid2206.150579 88:(DRC), where the more 863:Sklenovská N (2020). 256:Republic of the Congo 1432:Agence France-Presse 446:"8. Monkeypox virus" 1393:Süddeutsche Zeitung 911:2010PNAS..10716262R 905:(37): 16262–16267. 450:The Orthopoxviruses 317:national government 1524:Previous outbreaks 1438:. 26 August 2024. 1201:The New York Times 512:"32.2. Poxviruses" 334:federal government 226:2023-2024 outbreak 1840: 1839: 1783: 1782: 1591: 1590: 1571:Endemic countries 1172:. 5 August 2024. 878:978-981-15-2650-3 771:Euro Surveillance 655:978-3-7643-7556-0 585:"Monkeypox virus" 525:978-0-323-55512-8 489:978-92-4-156110-5 459:978-0-323-15022-4 364:on 14 August 2024 220:socially excluded 79: 78: 1865: 1821: 1820: 1795:Smallpox vaccine 1568: 1567: 1547: 1546: 1482: 1475: 1468: 1459: 1458: 1452: 1451: 1449: 1447: 1416: 1410: 1409: 1407: 1405: 1384: 1378: 1377: 1375: 1373: 1368:. 20 August 2024 1356: 1350: 1349: 1347: 1345: 1328: 1322: 1321: 1319: 1317: 1312:. 20 August 2024 1300: 1294: 1293: 1291: 1289: 1272: 1263: 1262: 1260: 1259: 1245: 1239: 1238: 1236: 1234: 1223: 1217: 1216: 1214: 1212: 1192: 1186: 1185: 1183: 1181: 1162: 1156: 1155: 1153: 1151: 1135: 1129: 1128: 1126: 1124: 1108: 1102: 1101: 1099: 1097: 1081: 1070: 1069: 1051: 1033: 1008: 1002: 1001: 991: 981: 957: 951: 950: 940: 922: 889: 883: 882: 860: 854: 853: 843: 819: 813: 812: 802: 762: 751: 750: 748: 746: 727: 716: 715: 705: 673: 660: 659: 637: 631: 630: 620: 580: 571: 570: 560: 536: 530: 529: 507: 494: 493: 481: 470: 464: 463: 441: 435: 434: 424: 391: 374: 373: 371: 369: 350: 306: 187: 175: 163: 151: 125:1996 reemergence 30: 18: 17: 1873: 1872: 1868: 1867: 1866: 1864: 1863: 1862: 1843: 1842: 1841: 1836: 1809: 1779: 1763: 1730: 1702: 1634: 1587: 1566: 1538: 1512: 1507:Monkeypox virus 1491: 1486: 1456: 1455: 1445: 1443: 1418: 1417: 1413: 1403: 1401: 1386: 1385: 1381: 1371: 1369: 1358: 1357: 1353: 1343: 1341: 1330: 1329: 1325: 1315: 1313: 1302: 1301: 1297: 1287: 1285: 1274: 1273: 1266: 1257: 1255: 1247: 1246: 1242: 1232: 1230: 1225: 1224: 1220: 1210: 1208: 1193: 1189: 1179: 1177: 1164: 1163: 1159: 1149: 1147: 1136: 1132: 1122: 1120: 1109: 1105: 1095: 1093: 1082: 1073: 1009: 1005: 958: 954: 890: 886: 879: 861: 857: 820: 816: 763: 754: 744: 742: 729: 728: 719: 674: 663: 656: 638: 634: 581: 574: 537: 533: 526: 508: 497: 490: 479: 471: 467: 460: 442: 438: 392: 377: 367: 365: 352: 351: 347: 342: 300: 290: 289: 236: 228: 198: 191: 188: 179: 176: 167: 164: 155: 152: 127: 104: 55:Monkeypox virus 35: 34: 12: 11: 5: 1871: 1861: 1860: 1855: 1838: 1837: 1835: 1834: 1827: 1814: 1811: 1810: 1808: 1807: 1802: 1797: 1791: 1789: 1785: 1784: 1781: 1780: 1778: 1777: 1771: 1769: 1765: 1764: 1762: 1761: 1756: 1751: 1746: 1740: 1738: 1732: 1731: 1729: 1728: 1723: 1718: 1712: 1710: 1704: 1703: 1701: 1700: 1698:United Kingdom 1695: 1690: 1685: 1680: 1675: 1670: 1665: 1660: 1655: 1650: 1644: 1642: 1636: 1635: 1633: 1632: 1627: 1622: 1617: 1612: 1607: 1601: 1599: 1593: 1592: 1589: 1588: 1586: 1585: 1580: 1574: 1572: 1565: 1564: 1559: 1553: 1551: 1544: 1540: 1539: 1537: 1536: 1531: 1526: 1520: 1518: 1514: 1513: 1511: 1510: 1503: 1496: 1493: 1492: 1485: 1484: 1477: 1470: 1462: 1454: 1453: 1428:Deutsche Welle 1411: 1379: 1351: 1323: 1295: 1264: 1240: 1218: 1187: 1157: 1130: 1103: 1071: 1003: 952: 884: 877: 865:"2. 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Index


Mpox
Monkeypox virus
Democratic Republic of the Congo
Mpox
Democratic Republic of the Congo
virulent
clade
mpox
smallpox
World Health Organization
chicken pox
Kasaï-Oriental
Mpox outbreak in DRC (1997)
The US epidemiologic team after having landed at Lodja Airport - DRC 1997
Testing of Gambian rats (1997)
Educational meeting DRC (1997)
Mpox
virulent
clade
socially excluded
Mpox § 2023–2024 Central Africa outbreak
South Kivu
Kinshasa
Republic of the Congo
Burundi
Rwanda
Uganda
Kenya
Cote d'Ivoire

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