170:
384:
2260:
302:
seems to wane with time. After four years, reductions were 36 percent for children who received three shots and a booster dose. Missing the booster dose reduced the efficacy against severe malaria to a negligible effect. The vaccine was shown to be less effective for infants. Three doses of vaccine plus a booster reduced the risk of clinical episodes by 26 percent over three years but offered no significant protection against severe malaria.
397:
3419:
374:
million children in Ghana, Kenya and Malawi had received at least one injection of the vaccine, with more than 4.5 million doses of the vaccine administered through the countries' routine immunization programs. The next 9 countries to receive the vaccine over the next 2 years are Benin, Burkina Faso,
312:
In July 2015, Mosquirix received a positive scientific opinion from the
European Medicines Agency on the proposal for the vaccine to be used to vaccinate children aged 6 weeks to 17 months outside the European Union. It is the world's first licensed malaria vaccine and also the first vaccine licensed
301:
In
October 2013, preliminary results of a phase III clinical trial indicated that RTS,S/AS01 reduced the number of cases among young children by almost 50 percent and among infants by around 25 percent. The study ended in 2014. The effects of a booster dose were positive, even though overall efficacy
297:
In
November 2012, a phase III trial of RTS,S found that it provided modest protection against both clinical and severe malaria in young infants. The RTS,S-based vaccine formulation had previously been demonstrated to be safe, well tolerated, immunogenic, and to potentially confer partial efficacy in
235:
Potential malaria vaccines have been an intense area of research since the 1960s. SPf66 was tested extensively in endemic areas in the 1990s, but clinical trials showed it to be insufficiently effective. Other vaccine candidates, targeting the blood-stage of the malaria parasite's life cycle, had
208:
million children living in areas with moderate-to-high malaria transmission, with millions more doses to be provided as the vaccine's production expands. 18 million doses have been allocated for 2023-2025. It requires at least three doses in infants by age 2, with a fourth dose extending the
1732:
Asante KP, Abdulla S, Agnandji S, Lyimo J, Vekemans J, Soulanoudjingar S, et al. (October 2011). "Safety and efficacy of the RTS,S/AS01E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial".
293:'The outcome was extremely promising', wrote Ripley Ballou in 2009, 'not only was the vaccine extremely well tolerated and highly immunogenic – it reduced the risk of infection by 65.9 percent (95 percent CI: 42.6– 79.8 percent, P < 0.0001) during a three-month follow-up period.'
227:) is the only malaria vaccine approved and in current use. The vaccine's use requires at least three doses in infants by age 2, with a fourth dose extending the protection for another 1–2 years. The vaccine reduces hospital admissions from severe malaria by around 30%.
325:(MPAC) jointly and unexpectedly recommended a pilot implementation in Africa, arguing for the need to rule out any increase in meningitis, something that a post-hoc analysis had found in children who had received the vaccine.
1095:
328:
In
November 2016, WHO announced that the RTS,S vaccine would be rolled out in pilot projects in three countries in sub-Saharan Africa. This pilot project for vaccination was launched on 23 April 2019 in
1187:
639:
289:
in 1998. Subsequent phase I and II field trials were run in different regions with different dosages: first in 6–11 year old children, then in 1–4 year olds, and finally in younger infants.
1480:"Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial"
1529:"Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics"
582:
367:
million doses of the RTS,S vaccine over three years. More than 30 countries have areas with moderate to high malaria transmission where the vaccine is expected to be useful.
2247:
875:
309:(EMA) in July 2014. GSK treated the project as a non-profit initiative, with most funding coming from the Gates Foundation, a major contributor to malaria eradication.
2237:
1099:
453:). This protein was then mixed with additional HBsAg to improve purification, hence the extra "S". Together, these two protein components assemble into soluble
1265:
1179:
839:
1288:
2272:
3322:
305:
In a bid to accommodate a larger group and guarantee a sustained availability for the general public, GSK applied for a marketing license with the
1762:
Wilby KJ, Lau TT, Gilchrist SE, Ensom MH (March 2012). "Mosquirix (RTS,S): a novel vaccine for the prevention of
Plasmodium falciparum malaria".
1811:
2470:
840:"Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research"
209:
protection for another 1–2 years. The vaccine reduces hospital admissions from severe malaria by around 30% and reduces toddler deaths by 15%.
1314:
2359:
1806:
611:
2510:
2505:
274:
to boost the immune response. Infection is prevented by inducing high antibody titers that block the parasite from infecting the liver.
439:
in 1986. It was named RTS because it was engineered using genes from the repeat ('R') and T-cell epitope ('T') of the pre-erythrocytic
1439:"Hepatitis B Surface Antigen as Carrier Matrix for the Repetitive Epitope of the Circumsporozoite Protein of Plasmodium Falciparum"
2902:
2691:
2520:
654:
248:
239:
The RTS,S vaccine was conceived of and created in the late 1980s by scientists working at SmithKline
Beecham Biologicals (now
3373:
3301:
352:
vaccine candidate, and first vaccine to address parasitic infection, to receive this recommendation. As of April 2022, 1
256:
2907:
2142:
2939:
2696:
2622:
2475:
318:
2302:
1366:
3349:
2661:
2294:
2197:
1156:
640:"18 million doses of first-ever malaria vaccine allocated to 12 African countries for 2023–2025: Gavi, WHO and UNICEF"
2761:
1838:
322:
260:
1266:"Malaria vaccine launched in Kenya: Kenya joins Ghana and Malawi to roll out landmark vaccine in pilot introduction"
3390:
3328:
2303:
2227:
2222:
1637:"Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites"
894:"Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection"
2949:
2917:
2912:
2746:
2080:
281:
was conducted in 1997, with six out of seven volunteers developing protection against the parasite. A successful
107:
3007:
2617:
2164:
1243:
1122:
1580:"Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts"
946:
2805:
2515:
2242:
2217:
2015:
2127:
1881:
148:
892:
Foquet L, Hermsen CC, van Gemert GJ, Van
Braeckel E, Weening KE, Sauerwein R, et al. (January 2014).
1635:
Swearingen KE, Lindner SE, Flannery EL, Vaughan AM, Morrison RD, Patrapuvich R, et al. (July 2017).
282:
3409:
2927:
2369:
2352:
2192:
1437:
Rutgers T, Gordon D, Gathoye AM, Hollingdale M, Hockmeyer W, Rosenberg M, De Wilde M (September 1988).
971:
Agnandji ST, Lell B, Fernandes JF, Abossolo BP, Methogo BG, Kabwende AL, et al. (December 2012).
3444:
3439:
2977:
2232:
1371:
1340:
1318:
1183:
523:
345:
306:
17:
2932:
2897:
2892:
2887:
2159:
2008:
440:
375:
Burundi, Cameroon, the
Democratic Republic of the Congo, Liberia, Niger, Sierra Leone, and Uganda.
3378:
3311:
3292:
3088:
3060:
3022:
3017:
2997:
2525:
2212:
2089:
1950:
1898:
838:
Heppner DG, Kester KE, Ockenhouse CF, Tornieporth N, Ofori O, Lyon JA, et al. (March 2005).
169:
90:
80:
68:
3359:
3288:
2287:
1578:
Lopaticki S, Yang AS, John A, Scott NE, Lingford JP, O'Neill MT, et al. (September 2017).
383:
1070:
3354:
3188:
3183:
2639:
2585:
2495:
2169:
2137:
1945:
1911:
1893:
1831:
489:
445:
278:
51:
356:
million children in Ghana, Kenya and Malawi have received at least one shot of the vaccine.
137:
3237:
3178:
2969:
2612:
2490:
2441:
2408:
2342:
2065:
1591:
461:
157:
1527:
Swearingen KE, Lindner SE, Shi L, Shears MJ, Harupa A, Hopp CS, et al. (April 2016).
8:
3160:
3126:
3012:
2835:
2778:
2773:
2724:
2555:
2423:
2395:
2347:
2122:
2025:
1998:
1932:
1925:
454:
128:
2830:
2575:
1595:
999:
972:
678:
Philosophical
Transactions of the Royal Society of London. Series B, Biological Sciences
583:"First malaria vaccine hits 1 million dose milestone — although it has its shortcomings"
414:
Please expand the section to include this information. Further details may exist on the
3193:
3027:
2768:
2734:
2719:
2595:
2580:
2565:
2485:
2403:
2202:
2187:
2132:
1787:
1663:
1636:
1612:
1579:
1555:
1528:
1504:
1479:
1460:
1419:
1051:
918:
893:
867:
796:
771:
747:
722:
698:
673:
468:) was added to increase the immune system response. Infection is prevented by inducing
449:
malaria parasite together with a viral surface antigen ('S') of the hepatitis B virus (
1746:
1495:
1407:
1219:
1202:
3316:
3283:
3116:
2957:
2847:
2741:
2602:
2427:
2390:
2280:
2149:
1779:
1750:
1709:
1668:
1617:
1560:
1509:
1423:
1411:
1224:
1043:
1004:
923:
859:
819:
801:
752:
703:
473:
314:
3262:
1791:
1464:
1055:
871:
3449:
3242:
3227:
3083:
2944:
2857:
2263:
2035:
2003:
1918:
1904:
1876:
1866:
1824:
1771:
1742:
1699:
1658:
1648:
1607:
1599:
1550:
1540:
1499:
1491:
1450:
1403:
1214:
1035:
994:
984:
913:
905:
851:
791:
783:
742:
734:
693:
685:
495:
469:
2783:
1180:"Pilot implementation of first malaria vaccine recommended by WHO advisory groups"
855:
519:
3423:
3247:
3045:
2852:
2810:
2701:
2681:
2651:
2634:
2560:
2550:
2480:
2419:
2415:
2364:
2207:
2070:
2042:
1653:
1545:
612:"Millions more children to benefit from malaria vaccine as UNICEF secures supply"
436:
240:
218:
193:
189:
185:
247:. The vaccine was further developed through a collaboration between GSK and the
3384:
3111:
3002:
2962:
2842:
2668:
2607:
1603:
1344:
787:
738:
545:
3433:
3267:
3252:
3222:
3217:
3072:
2825:
2820:
2729:
2374:
2020:
1983:
1871:
2629:
3344:
2987:
2882:
2815:
2756:
2436:
2327:
2307:
2154:
1993:
1783:
1754:
1713:
1672:
1621:
1564:
1513:
1415:
1228:
1148:
1096:"GSK announces EU regulatory submission of malaria vaccine candidate RTS,S"
1047:
1008:
927:
863:
805:
756:
707:
689:
484:
197:
1704:
1687:
1394:
Devi S (July 2023). "12 countries to get first doses of malaria vaccine".
989:
3131:
3121:
2982:
2788:
2676:
2644:
2570:
2432:
2323:
2315:
2094:
2030:
1688:"Implications of Plasmodium glycosylation on vaccine efficacy and design"
1455:
1438:
56:
3257:
3232:
2922:
2872:
2099:
2075:
1965:
1960:
1888:
1775:
1268:(Press release). Homa Bay: World Health Organization. 13 September 2019
415:
298:
both malaria-naive and malaria-experienced adults as well as children.
286:
63:
1039:
887:
885:
270:
malaria parasite and a portion of a hepatitis B virus plus a chemical
33:
3306:
2877:
2750:
2319:
2104:
1955:
1940:
909:
435:
The RTS,S vaccine is based on a protein construct first developed by
1315:"WHO recommends groundbreaking malaria vaccine for children at risk"
1023:
3148:
3141:
3136:
3106:
2862:
2798:
2793:
1152:
891:
882:
271:
252:
1477:
973:"A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants"
837:
2867:
2311:
1861:
1847:
349:
244:
201:
40:
1634:
1341:"A 'Historical Event': First Malaria Vaccine Approved by W.H.O."
947:"Why we didn't get a malaria vaccine sooner - Works in Progress"
396:
3170:
3155:
2446:
1436:
1071:"Malaria vaccine candidate shown to prevent thousands of cases"
616:
360:
330:
3165:
2656:
2590:
2248:
European and
Developing Countries Clinical Trials Partnership
1289:"WHO endorses use of world's first malaria vaccine in Africa"
970:
477:
450:
409:
338:
334:
1203:"Implementation of the malaria candidate vaccine RTS,S/AS01"
2465:
266:
RTS,S was engineered using genes from the outer protein of
1816:
1731:
1526:
1988:
1021:
655:"First malaria vaccine slashes early childhood mortality"
964:
552:. Global Health Technologies Coalition. 15 November 2019
412:
and 3D-MPL (detoxified Lipid A). PMID 22521140 may help.
2238:
The Global Fund to Fight AIDS, Tuberculosis and Malaria
546:"RTS,S Malaria Vaccine: 2019 Partnership Award Honoree"
348:(WHO) for "broad use" in children, making it the first
1761:
1577:
3407:
941:
939:
937:
820:"HYBRID PROTEIN BETWEEN CS FROM PLASMODIUM AND HBsAG"
770:
Graves P, Gelband H (October 2006). Graves PM (ed.).
1685:
499:, while the RTS,S vaccine produced in yeast is not.
480:, that block the parasite from infecting the liver.
1022:Regules JA, Cummings JF, Ockenhouse CF (May 2011).
721:Graves P, Gelband H (April 2006). Graves PM (ed.).
457:similar to the outer shell of a hepatitis B virus.
1123:"GSK aims to market world's first malaria vaccine"
1098:(Press release). GSK. 24 July 2014. Archived from
934:
3323:Cedillo v. Secretary of Health and Human Services
344:In October 2021, the vaccine was endorsed by the
3431:
1478:RTS, S Clinical Trials Partnership (July 2015).
1246:(Press release). Wuxi: World Health Organization
173:A poster advertising trials of the RTS,S vaccine
1200:
833:
831:
829:
772:"Vaccines for preventing malaria (blood-stage)"
606:
604:
136:
255:and has been funded in part by the non-profit
2288:
1832:
769:
720:
1312:
1194:
826:
601:
577:
575:
573:
571:
569:
567:
387:RTS,S recombinant protein viruslike particle
776:The Cochrane Database of Systematic Reviews
727:The Cochrane Database of Systematic Reviews
378:
115:In general: â„ž (Prescription only)
2295:
2281:
1839:
1825:
1338:
1703:
1686:Goddard-Borger ED, Boddey JA (May 2018).
1662:
1652:
1611:
1554:
1544:
1503:
1454:
1218:
1024:"The RTS,S vaccine candidate for malaria"
998:
988:
917:
795:
746:
723:"Vaccines for preventing malaria (SPf66)"
697:
564:
408:about more on the adjuvant—liposome with
156:
1367:"Q&A on RTS,S malaria vaccine - WHO"
1068:
382:
363:awarded a contract to GSK to purchase 18
317:of any kind. On 23 October 2015, WHO's
168:
1359:
1201:Greenwood B, Doumbo OK (January 2016).
1190:from the original on 19 September 2021.
1177:
1140:
1120:
14:
3432:
1286:
1241:
652:
249:Walter Reed Army Institute of Research
2276:
1820:
1146:
898:The Journal of Clinical Investigation
514:
512:
257:PATH Malaria Vaccine Initiative (MVI)
236:also been insufficient on their own.
97:intramuscular injection (0.5 mL)
2143:National Malaria Eradication Program
1393:
1258:
1235:
1149:"Malaria vaccine gets 'green light'"
671:
390:
2198:Bill & Melinda Gates Foundation
1812:Mosquirix: Public Assessment Report
1213:(10016). London, England: 318–319.
977:The New England Journal of Medicine
319:Strategic Advisory Group of Experts
24:
3350:Eradication of infectious diseases
3107:Androvax (androstenedione albumin)
1724:
878:from the original on 23 July 2018.
509:
25:
3461:
2940:Respiratory syncytial virus (RSV)
1800:
1159:from the original on 21 July 2020
323:Malaria Policy Advisory Committee
261:Bill and Melinda Gates Foundation
3417:
3329:Alternative vaccination schedule
2304:Artificial induction of immunity
2259:
2258:
2228:African Leaders Malaria Alliance
2223:South African Malaria Initiative
1641:PLOS Neglected Tropical Diseases
1244:"Letter to partners – June 2019"
395:
243:(GSK) Vaccines) laboratories in
2081:Malaria antigen detection tests
1735:The Lancet. Infectious Diseases
1679:
1628:
1571:
1520:
1471:
1430:
1387:
1339:Mandavilli A (6 October 2021).
1332:
1306:
1280:
1171:
1114:
1088:
1062:
1015:
812:
321:on Immunization (SAGE) and the
212:
3161:Ovandrotone albumin (Fecundin)
2165:Malaria in Mandatory Palestine
1807:Mosquirix: Product information
763:
714:
665:
646:
632:
538:
337:, and on 13 September 2019 in
200:). As of April 2022, the
13:
1:
2697:Group B streptococcal disease
2516:Vaccines for Children Program
2243:Medicines for Malaria Venture
2218:African Malaria Network Trust
1764:The Annals of Pharmacotherapy
1747:10.1016/S1473-3099(11)70100-1
1496:10.1016/S0140-6736(15)60721-8
1408:10.1016/s0140-6736(23)01456-3
1220:10.1016/S0140-6736(15)00807-7
1178:Stewart S (23 October 2015).
856:10.1016/j.vaccine.2005.01.142
502:
483:The T-cell epitope of CSP is
285:took place in adult males in
2128:Millennium Development Goals
1654:10.1371/journal.pntd.0005791
1546:10.1371/journal.ppat.1005606
1121:Kelland K (7 October 2013).
1069:Borghino D (27 April 2015).
653:Wadman M (24 October 2023).
223:RTS,S/AS01 (commercial name
7:
1846:
1287:Davies L (6 October 2021).
10:
3466:
2193:Against Malaria Foundation
1604:10.1038/s41467-017-00571-y
674:"Vaccines against malaria"
370:As of April 2023, 1.5
230:
216:
3368:
3337:
3276:
3208:
3099:
3071:
3038:
2712:
2543:
2536:
2455:
2383:
2335:
2256:
2233:Amazon Malaria Initiative
2180:
2115:
2058:
1976:
1854:
1372:World Health Organization
1319:World Health Organization
1317:(Press release). Geneva:
1242:Alonso P (19 June 2019).
1184:World Health Organization
1182:(Press release). Geneva:
1028:Expert Review of Vaccines
788:10.1002/14651858.CD006199
739:10.1002/14651858.CD005966
524:European Medicines Agency
346:World Health Organization
307:European Medicines Agency
147:
127:
122:
106:
101:
89:
79:
74:
62:
46:
39:
2692:Clostridioides difficile
2160:Malaria in the Caribbean
2009:Sterile insect technique
1313:Drysdale C, Kelleher K.
1147:Walsh F (24 July 2015).
672:Hill AV (October 2011).
464:(AS01, specifically AS01
441:circumsporozoite protein
379:Components and mechanism
313:for use against a human
2950:Tick-borne encephalitis
2213:Africa Fighting Malaria
2059:Diagnosis and treatment
196:approved (the other is
3360:List of vaccine topics
2360:Mathematical modelling
1977:Control and prevention
690:10.1098/rstb.2011.0091
526:(EMA). 8 December 2020
406:is missing information
388:
333:, on 30 April 2019 in
295:
174:
3355:Vaccinate Your Family
2806:Japanese encephalitis
2170:Malaria Atlas Project
1705:10.2217/fmb-2017-0284
1584:Nature Communications
990:10.1056/NEJMoa1208394
490:Plasmodium falciparum
476:, with high antibody
446:Plasmodium falciparum
386:
291:
279:human challenge study
251:in the U.S. state of
172:
55:; to a lesser extent
3238:John Franklin Enders
2066:Diagnosis of malaria
1882:Pregnancy-associated
1456:10.1038/nbt0988-1065
1443:Nature Biotechnology
850:(17–18): 2243–2250.
520:"Mosquirix H-W-2300"
455:virus-like particles
2424:Virus-like particle
2348:Vaccine ingredients
2123:Diseases of poverty
2116:Society and malaria
2026:Sickle-cell anaemia
1999:Malaria prophylaxis
1692:Future Microbiology
1596:2017NatCo...8..561L
684:(1579): 2806–2814.
204:has been given to 1
192:. It is one of two
186:recombinant protein
41:Vaccine description
36:
3395:Never to phase III
3194:Hexavalent vaccine
3008:Epstein–Barr virus
2903:Oxford–AstraZeneca
2596:NmVac4-A/C/Y/W-135
2203:Imagine No Malaria
2188:Malaria Consortium
2133:History of malaria
2016:Genetic resistance
1941:Anopheles mosquito
1776:10.1345/aph.1AQ634
1102:on 4 December 2016
951:worksinprogress.co
389:
175:
32:
3405:
3404:
3317:Vaccines and SIDS
3204:
3203:
2978:Hepatitis A and B
2954:Varicella zoster
2416:Subunit/component
2270:
2269:
2150:World Malaria Day
1040:10.1586/erv.11.57
983:(24): 2284–2295.
474:cellular immunity
433:
432:
315:parasitic disease
167:
166:
16:(Redirected from
3457:
3445:Subunit vaccines
3440:Peptide vaccines
3422:
3421:
3420:
3413:
3296:MMR autism fraud
3243:Maurice Hilleman
3228:Hilary Koprowski
2541:
2540:
2297:
2290:
2283:
2274:
2273:
2262:
2261:
2036:G6PDH deficiency
2004:Mosquito control
1877:Blackwater fever
1841:
1834:
1827:
1818:
1817:
1795:
1758:
1718:
1717:
1707:
1683:
1677:
1676:
1666:
1656:
1632:
1626:
1625:
1615:
1575:
1569:
1568:
1558:
1548:
1524:
1518:
1517:
1507:
1475:
1469:
1468:
1458:
1449:(9): 1065–1070.
1434:
1428:
1427:
1391:
1385:
1384:
1382:
1380:
1363:
1357:
1356:
1354:
1352:
1336:
1330:
1329:
1327:
1325:
1310:
1304:
1303:
1301:
1299:
1284:
1278:
1277:
1275:
1273:
1262:
1256:
1255:
1253:
1251:
1239:
1233:
1232:
1222:
1198:
1192:
1191:
1175:
1169:
1168:
1166:
1164:
1144:
1138:
1137:
1135:
1133:
1118:
1112:
1111:
1109:
1107:
1092:
1086:
1085:
1083:
1081:
1066:
1060:
1059:
1019:
1013:
1012:
1002:
992:
968:
962:
961:
959:
957:
943:
932:
931:
921:
910:10.1172/JCI70349
889:
880:
879:
835:
824:
823:
816:
810:
809:
799:
767:
761:
760:
750:
718:
712:
711:
701:
669:
663:
662:
650:
644:
643:
636:
630:
629:
627:
625:
620:. 16 August 2022
608:
599:
598:
596:
594:
579:
562:
561:
559:
557:
542:
536:
535:
533:
531:
516:
496:Plasmodium vivax
428:
425:
419:
399:
391:
373:
366:
359:In August 2022,
355:
207:
194:malaria vaccines
160:
140:
37:
35:
31:
21:
3465:
3464:
3460:
3459:
3458:
3456:
3455:
3454:
3430:
3429:
3428:
3418:
3416:
3408:
3406:
3401:
3400:
3385:Clinical trials
3364:
3333:
3272:
3248:Stanley Plotkin
3210:
3200:
3112:Cancer vaccines
3095:
3089:Schistosomiasis
3067:
3061:Trypanosomiasis
3034:
2998:Cytomegalovirus
2908:Pfizer–BioNTech
2708:
2532:
2481:Vaccine wastage
2451:
2379:
2331:
2301:
2271:
2266:
2252:
2208:Malaria No More
2176:
2111:
2071:Malaria culture
2054:
2043:Malaria vaccine
1972:
1850:
1845:
1803:
1798:
1741:(10): 741–749.
1727:
1725:Further reading
1722:
1721:
1684:
1680:
1647:(7): e0005791.
1633:
1629:
1576:
1572:
1539:(4): e1005606.
1525:
1521:
1490:(9988): 31–45.
1476:
1472:
1435:
1431:
1392:
1388:
1378:
1376:
1375:. 19 April 2023
1365:
1364:
1360:
1350:
1348:
1337:
1333:
1323:
1321:
1311:
1307:
1297:
1295:
1285:
1281:
1271:
1269:
1264:
1263:
1259:
1249:
1247:
1240:
1236:
1199:
1195:
1176:
1172:
1162:
1160:
1145:
1141:
1131:
1129:
1119:
1115:
1105:
1103:
1094:
1093:
1089:
1079:
1077:
1067:
1063:
1020:
1016:
969:
965:
955:
953:
945:
944:
935:
890:
883:
836:
827:
818:
817:
813:
782:(4): CD006199.
768:
764:
733:(2): CD005966.
719:
715:
670:
666:
651:
647:
638:
637:
633:
623:
621:
610:
609:
602:
592:
590:
581:
580:
565:
555:
553:
544:
543:
539:
529:
527:
518:
517:
510:
505:
467:
437:GlaxoSmithKline
429:
423:
420:
413:
400:
381:
371:
364:
353:
241:GlaxoSmithKline
233:
221:
219:Malaria vaccine
215:
205:
190:malaria vaccine
163:
143:
118:
92:
69:Protein subunit
28:
27:Malaria vaccine
23:
22:
15:
12:
11:
5:
3463:
3453:
3452:
3447:
3442:
3427:
3426:
3403:
3402:
3399:
3398:
3397:
3396:
3393:
3382:
3376:
3370:
3369:
3366:
3365:
3363:
3362:
3357:
3352:
3347:
3341:
3339:
3335:
3334:
3332:
3331:
3326:
3319:
3314:
3309:
3304:
3299:
3286:
3280:
3278:
3274:
3273:
3271:
3270:
3265:
3263:Katalin KarikĂł
3260:
3255:
3250:
3245:
3240:
3235:
3230:
3225:
3220:
3214:
3212:
3206:
3205:
3202:
3201:
3199:
3198:
3197:
3196:
3191:
3186:
3181:
3173:
3168:
3163:
3158:
3153:
3152:
3151:
3146:
3145:
3144:
3139:
3129:
3124:
3119:
3109:
3103:
3101:
3097:
3096:
3094:
3093:
3092:
3091:
3086:
3077:
3075:
3069:
3068:
3066:
3065:
3064:
3063:
3055:
3054:
3053:
3042:
3040:
3036:
3035:
3033:
3032:
3031:
3030:
3025:
3020:
3018:Herpes simplex
3015:
3010:
3005:
3000:
2992:
2991:
2990:
2985:
2980:
2972:
2967:
2966:
2965:
2960:
2952:
2947:
2942:
2937:
2936:
2935:
2930:
2925:
2920:
2918:Sinopharm BIBP
2915:
2910:
2905:
2900:
2895:
2890:
2885:
2880:
2875:
2870:
2868:Bharat Biotech
2865:
2855:
2850:
2845:
2840:
2839:
2838:
2833:
2823:
2818:
2813:
2808:
2803:
2802:
2801:
2796:
2786:
2781:
2776:
2771:
2766:
2765:
2764:
2759:
2754:
2739:
2738:
2737:
2727:
2722:
2716:
2714:
2710:
2709:
2707:
2706:
2705:
2704:
2699:
2694:
2686:
2685:
2684:
2679:
2671:
2666:
2665:
2664:
2659:
2649:
2648:
2647:
2637:
2632:
2627:
2626:
2625:
2620:
2610:
2605:
2600:
2599:
2598:
2593:
2583:
2578:
2573:
2568:
2563:
2558:
2553:
2547:
2545:
2538:
2534:
2533:
2531:
2530:
2529:
2528:
2523:
2518:
2513:
2508:
2500:
2499:
2498:
2496:Vaccine injury
2493:
2488:
2483:
2478:
2473:
2468:
2459:
2457:
2456:Administration
2453:
2452:
2450:
2449:
2444:
2439:
2430:
2413:
2412:
2411:
2406:
2398:
2393:
2387:
2385:
2381:
2380:
2378:
2377:
2372:
2367:
2362:
2357:
2356:
2355:
2345:
2339:
2337:
2333:
2332:
2300:
2299:
2292:
2285:
2277:
2268:
2267:
2257:
2254:
2253:
2251:
2250:
2245:
2240:
2235:
2230:
2225:
2220:
2215:
2210:
2205:
2200:
2195:
2190:
2184:
2182:
2178:
2177:
2175:
2174:
2173:
2172:
2167:
2162:
2152:
2147:
2146:
2145:
2140:
2130:
2125:
2119:
2117:
2113:
2112:
2110:
2109:
2108:
2107:
2102:
2097:
2086:
2085:
2084:
2083:
2078:
2073:
2062:
2060:
2056:
2055:
2053:
2052:
2051:
2050:
2040:
2039:
2038:
2033:
2028:
2023:
2013:
2012:
2011:
2006:
2001:
1996:
1991:
1980:
1978:
1974:
1973:
1971:
1970:
1969:
1968:
1963:
1958:
1953:
1943:
1938:
1937:
1936:
1929:
1922:
1915:
1908:
1901:
1896:
1886:
1885:
1884:
1879:
1874:
1869:
1858:
1856:
1852:
1851:
1844:
1843:
1836:
1829:
1821:
1815:
1814:
1809:
1802:
1801:External links
1799:
1797:
1796:
1770:(3): 384–393.
1759:
1728:
1726:
1723:
1720:
1719:
1698:(6): 609–612.
1678:
1627:
1570:
1533:PLOS Pathogens
1519:
1470:
1429:
1402:(10397): 172.
1386:
1358:
1345:New York Times
1331:
1305:
1279:
1257:
1234:
1193:
1170:
1139:
1113:
1087:
1075:www.gizmag.com
1061:
1034:(5): 589–599.
1014:
963:
933:
904:(1): 140–144.
881:
825:
811:
762:
713:
664:
645:
631:
600:
563:
537:
507:
506:
504:
501:
465:
431:
430:
403:
401:
394:
380:
377:
232:
229:
217:Main article:
214:
211:
165:
164:
162:
161:
153:
151:
145:
144:
142:
141:
133:
131:
125:
124:
120:
119:
117:
116:
112:
110:
104:
103:
99:
98:
95:
93:administration
87:
86:
83:
77:
76:
72:
71:
66:
60:
59:
48:
44:
43:
26:
9:
6:
4:
3:
2:
3462:
3451:
3448:
3446:
3443:
3441:
3438:
3437:
3435:
3425:
3415:
3414:
3411:
3394:
3392:
3389:
3388:
3386:
3383:
3380:
3377:
3375:
3372:
3371:
3367:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3343:
3342:
3340:
3336:
3330:
3327:
3325:
3324:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3297:
3295:
3290:
3287:
3285:
3282:
3281:
3279:
3275:
3269:
3268:Drew Weissman
3266:
3264:
3261:
3259:
3256:
3254:
3253:H. Fred Clark
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3223:Louis Pasteur
3221:
3219:
3218:Edward Jenner
3216:
3215:
3213:
3207:
3195:
3192:
3190:
3189:DTwP-HepB-Hib
3187:
3185:
3184:DTaP-IPV-HepB
3182:
3180:
3177:
3176:
3175:combination:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3150:
3147:
3143:
3140:
3138:
3135:
3134:
3133:
3130:
3128:
3125:
3123:
3120:
3118:
3115:
3114:
3113:
3110:
3108:
3105:
3104:
3102:
3098:
3090:
3087:
3085:
3082:
3081:
3079:
3078:
3076:
3074:
3073:Helminthiasis
3070:
3062:
3059:
3058:
3056:
3052:
3049:
3048:
3047:
3044:
3043:
3041:
3037:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2999:
2996:
2995:
2993:
2989:
2986:
2984:
2981:
2979:
2976:
2975:
2974:combination:
2973:
2971:
2968:
2964:
2961:
2959:
2956:
2955:
2953:
2951:
2948:
2946:
2943:
2941:
2938:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2906:
2904:
2901:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2871:
2869:
2866:
2864:
2861:
2860:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2841:
2837:
2834:
2832:
2829:
2828:
2827:
2824:
2822:
2819:
2817:
2814:
2812:
2809:
2807:
2804:
2800:
2797:
2795:
2792:
2791:
2790:
2787:
2785:
2782:
2780:
2777:
2775:
2772:
2770:
2767:
2763:
2760:
2758:
2755:
2752:
2748:
2745:
2744:
2743:
2740:
2736:
2733:
2732:
2731:
2728:
2726:
2723:
2721:
2718:
2717:
2715:
2711:
2703:
2700:
2698:
2695:
2693:
2690:
2689:
2687:
2683:
2680:
2678:
2677:DPT/DTwP/DTaP
2675:
2674:
2673:combination:
2672:
2670:
2667:
2663:
2660:
2658:
2655:
2654:
2653:
2650:
2646:
2643:
2642:
2641:
2638:
2636:
2633:
2631:
2628:
2624:
2621:
2619:
2616:
2615:
2614:
2611:
2609:
2606:
2604:
2601:
2597:
2594:
2592:
2589:
2588:
2587:
2586:Meningococcus
2584:
2582:
2579:
2577:
2576:Leptospirosis
2574:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2548:
2546:
2542:
2539:
2535:
2527:
2524:
2522:
2519:
2517:
2514:
2512:
2511:Vaccine court
2509:
2507:
2504:
2503:
2501:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2477:
2474:
2472:
2469:
2467:
2466:GAVI Alliance
2464:
2463:
2461:
2460:
2458:
2454:
2448:
2445:
2443:
2440:
2438:
2434:
2431:
2429:
2425:
2421:
2417:
2414:
2410:
2407:
2405:
2402:
2401:
2399:
2397:
2394:
2392:
2389:
2388:
2386:
2382:
2376:
2373:
2371:
2368:
2366:
2363:
2361:
2358:
2354:
2351:
2350:
2349:
2346:
2344:
2341:
2340:
2338:
2334:
2329:
2325:
2321:
2317:
2313:
2309:
2305:
2298:
2293:
2291:
2286:
2284:
2279:
2278:
2275:
2265:
2255:
2249:
2246:
2244:
2241:
2239:
2236:
2234:
2231:
2229:
2226:
2224:
2221:
2219:
2216:
2214:
2211:
2209:
2206:
2204:
2201:
2199:
2196:
2194:
2191:
2189:
2186:
2185:
2183:
2181:Organisations
2179:
2171:
2168:
2166:
2163:
2161:
2158:
2157:
2156:
2153:
2151:
2148:
2144:
2141:
2139:
2136:
2135:
2134:
2131:
2129:
2126:
2124:
2121:
2120:
2118:
2114:
2106:
2103:
2101:
2098:
2096:
2093:
2092:
2091:
2090:Antimalarials
2088:
2087:
2082:
2079:
2077:
2074:
2072:
2069:
2068:
2067:
2064:
2063:
2061:
2057:
2049:
2046:
2045:
2044:
2041:
2037:
2034:
2032:
2029:
2027:
2024:
2022:
2021:Duffy antigen
2019:
2018:
2017:
2014:
2010:
2007:
2005:
2002:
2000:
1997:
1995:
1992:
1990:
1987:
1986:
1985:
1984:Public health
1982:
1981:
1979:
1975:
1967:
1964:
1962:
1959:
1957:
1954:
1952:
1949:
1948:
1947:
1944:
1942:
1939:
1935:
1934:
1930:
1928:
1927:
1923:
1921:
1920:
1916:
1914:
1913:
1909:
1907:
1906:
1902:
1900:
1897:
1895:
1892:
1891:
1890:
1887:
1883:
1880:
1878:
1875:
1873:
1872:Quartan fever
1870:
1868:
1865:
1864:
1863:
1860:
1859:
1857:
1853:
1849:
1842:
1837:
1835:
1830:
1828:
1823:
1822:
1819:
1813:
1810:
1808:
1805:
1804:
1793:
1789:
1785:
1781:
1777:
1773:
1769:
1765:
1760:
1756:
1752:
1748:
1744:
1740:
1736:
1730:
1729:
1715:
1711:
1706:
1701:
1697:
1693:
1689:
1682:
1674:
1670:
1665:
1660:
1655:
1650:
1646:
1642:
1638:
1631:
1623:
1619:
1614:
1609:
1605:
1601:
1597:
1593:
1589:
1585:
1581:
1574:
1566:
1562:
1557:
1552:
1547:
1542:
1538:
1534:
1530:
1523:
1515:
1511:
1506:
1501:
1497:
1493:
1489:
1485:
1481:
1474:
1466:
1462:
1457:
1452:
1448:
1444:
1440:
1433:
1425:
1421:
1417:
1413:
1409:
1405:
1401:
1397:
1390:
1374:
1373:
1368:
1362:
1347:
1346:
1342:
1335:
1320:
1316:
1309:
1294:
1290:
1283:
1267:
1261:
1245:
1238:
1230:
1226:
1221:
1216:
1212:
1208:
1204:
1197:
1189:
1185:
1181:
1174:
1158:
1154:
1150:
1143:
1128:
1124:
1117:
1101:
1097:
1091:
1076:
1072:
1065:
1057:
1053:
1049:
1045:
1041:
1037:
1033:
1029:
1025:
1018:
1010:
1006:
1001:
996:
991:
986:
982:
978:
974:
967:
952:
948:
942:
940:
938:
929:
925:
920:
915:
911:
907:
903:
899:
895:
888:
886:
877:
873:
869:
865:
861:
857:
853:
849:
845:
841:
834:
832:
830:
821:
815:
807:
803:
798:
793:
789:
785:
781:
777:
773:
766:
758:
754:
749:
744:
740:
736:
732:
728:
724:
717:
709:
705:
700:
695:
691:
687:
683:
679:
675:
668:
660:
656:
649:
641:
635:
619:
618:
613:
607:
605:
589:. 13 May 2022
588:
584:
578:
576:
574:
572:
570:
568:
551:
547:
541:
525:
521:
515:
513:
508:
500:
498:
497:
492:
491:
486:
485:O-fucosylated
481:
479:
475:
471:
463:
458:
456:
452:
448:
447:
443:(CSP) of the
442:
438:
427:
417:
411:
407:
404:This section
402:
398:
393:
392:
385:
376:
368:
362:
357:
351:
347:
342:
340:
336:
332:
326:
324:
320:
316:
310:
308:
303:
299:
294:
290:
288:
284:
283:phase I trail
280:
275:
273:
269:
268:P. falciparum
264:
262:
258:
254:
250:
246:
242:
237:
228:
226:
220:
210:
203:
199:
195:
191:
187:
183:
179:
171:
159:
155:
154:
152:
150:
146:
139:
135:
134:
132:
130:
126:
121:
114:
113:
111:
109:
105:
100:
96:
94:
88:
84:
82:
78:
75:Clinical data
73:
70:
67:
65:
61:
58:
54:
53:
52:P. falciparum
49:
45:
42:
38:
30:
19:
3345:Epidemiology
3321:
3293:
3179:DTaP-IPV/Hib
3050:
2970:Yellow fever
2883:EpiVacCorona
2640:Tuberculosis
2613:Pneumococcal
2581:Lyme disease
2409:Heterologous
2308:Immunization
2155:Epidemiology
2047:
1994:Mosquito net
1931:
1924:
1917:
1910:
1903:
1767:
1763:
1738:
1734:
1695:
1691:
1681:
1644:
1640:
1630:
1587:
1583:
1573:
1536:
1532:
1522:
1487:
1483:
1473:
1446:
1442:
1432:
1399:
1395:
1389:
1377:. Retrieved
1370:
1361:
1349:. Retrieved
1343:
1334:
1322:. Retrieved
1308:
1296:. Retrieved
1293:The Guardian
1292:
1282:
1270:. Retrieved
1260:
1248:. Retrieved
1237:
1210:
1206:
1196:
1173:
1161:. Retrieved
1142:
1130:. Retrieved
1126:
1116:
1104:. Retrieved
1100:the original
1090:
1078:. Retrieved
1074:
1064:
1031:
1027:
1017:
980:
976:
966:
954:. Retrieved
950:
901:
897:
847:
843:
814:
779:
775:
765:
730:
726:
716:
681:
677:
667:
658:
648:
634:
622:. Retrieved
615:
591:. Retrieved
586:
554:. Retrieved
549:
540:
528:. Retrieved
494:
488:
482:
459:
444:
434:
424:October 2021
421:
405:
369:
358:
343:
327:
311:
304:
300:
296:
292:
276:
267:
265:
238:
234:
224:
222:
213:Medical uses
198:R21/Matrix-M
181:
180:(trade name
177:
176:
108:Legal status
102:Legal status
64:Vaccine type
50:
29:
3381:from market
3277:Controversy
3211:researchers
3127:Hepatitis B
3013:Hepatitis C
2958:Chicken pox
2784:Hepatitis E
2779:Hepatitis B
2774:Hepatitis A
2725:Chikungunya
2702:Shigellosis
2556:Brucellosis
2442:Therapeutic
2396:Inactivated
2336:Development
2324:Inoculation
2316:Vaccination
2138:Roman fever
2095:Artemisinin
2031:Thalassemia
460:A chemical
138:149121-47-1
123:Identifiers
81:Trade names
57:Hepatitis B
3434:Categories
3312:Thiomersal
3258:Paul Offit
3233:Jonas Salk
3209:Inventors/
3080:research:
3057:research:
2994:research:
2923:Skycovione
2913:Sanofi–GSK
2858:SARS-CoV-2
2769:Hantavirus
2735:rVSV-ZEBOV
2720:Adenovirus
2688:research:
2566:Diphtheria
2404:Attenuated
2100:Mefloquine
2076:Blood film
1966:Gametocyte
1961:Hypnozoite
1946:Life cycle
1912:falciparum
1899:life cycle
1889:Plasmodium
1590:(1): 561.
1272:22 October
1250:22 October
1132:9 December
956:28 October
503:References
287:The Gambia
277:The first
178:RTS,S/AS01
158:69SE2D63CL
129:CAS Number
3391:Phase III
3379:Withdrawn
3307:Pox party
3117:ALVAC-CEA
3039:Protozoan
2928:Sputnik V
2878:CoronaVac
2848:Rotavirus
2751:Pandemrix
2603:Pertussis
2544:Bacterial
2428:Synthetic
2391:Conjugate
2343:Adjuvants
2320:Infection
2105:Proguanil
1956:Merozoite
1424:259849056
1351:6 October
1324:6 October
1298:6 October
624:2 January
593:2 January
556:6 October
416:talk page
225:Mosquirix
182:Mosquirix
91:Routes of
85:Mosquirix
18:Mosquirix
3424:Medicine
3149:Prostvac
3142:Gardasil
3137:Cervarix
3084:Hookworm
2963:Shingles
2945:Smallpox
2863:Corbevax
2799:Gardasil
2794:Cervarix
2537:Vaccines
2491:Schedule
2462:Global:
2370:Timeline
2312:Vaccines
2264:Category
1951:Schizont
1933:knowlesi
1926:malariae
1867:Cerebral
1792:32412123
1784:22408046
1755:21782519
1714:29624074
1673:28759593
1622:28916755
1565:27128092
1514:25913272
1465:39880644
1416:37454658
1379:29 April
1229:26549465
1188:Archived
1157:Archived
1153:BBC News
1056:20443829
1048:21604980
1009:23136909
1000:10915853
928:24292709
876:Archived
872:22824901
864:15755604
806:17054281
757:16625647
708:21893544
462:adjuvant
272:adjuvant
259:and the
253:Maryland
3450:Malaria
3338:Related
3284:General
3046:Malaria
2933:Valneva
2898:Novavax
2893:Moderna
2888:Janssen
2873:CanSino
2853:Rubella
2811:Measles
2682:Td/Tdap
2652:Typhoid
2635:Tetanus
2630:Q fever
2561:Cholera
2551:Anthrax
2420:Peptide
2384:Classes
2365:Storage
1894:biology
1862:Malaria
1855:Biology
1848:Malaria
1664:5552340
1613:5601480
1592:Bibcode
1556:4851412
1505:5626001
1163:25 July
1127:Reuters
1106:30 July
1080:11 June
919:3871238
844:Vaccine
797:6532641
748:6532709
699:3146776
659:Science
550:YouTube
530:4 March
470:humoral
350:malaria
245:Belgium
231:History
202:vaccine
188:-based
184:) is a
3410:Portal
3374:WHO-EM
3294:Lancet
3171:TA-NIC
3156:NicVAX
3003:Dengue
2843:Rabies
2669:Typhus
2608:Plague
2486:Policy
2447:Toxoid
2375:Trials
1790:
1782:
1753:
1712:
1671:
1661:
1620:
1610:
1563:
1553:
1512:
1502:
1484:Lancet
1463:
1422:
1414:
1396:Lancet
1227:
1207:Lancet
1054:
1046:
1007:
997:
926:
916:
870:
862:
804:
794:
755:
745:
706:
696:
617:UNICEF
478:titers
372:
365:
361:UNICEF
354:
331:Malawi
206:
47:Target
3302:NCVIA
3166:TA-CD
3100:Other
3051:RTS,S
2831:Sabin
2826:Polio
2821:Mumps
2730:Ebola
2713:Viral
2662:ViCPS
2657:Ty21a
2591:MeNZB
2521:VAERS
2471:NITAG
2400:Live
2048:RTS,S
1919:ovale
1905:vivax
1788:S2CID
1461:S2CID
1420:S2CID
1052:S2CID
868:S2CID
451:HBsAg
410:QS-21
339:Kenya
335:Ghana
34:RTS,S
3028:Zika
2988:MMRV
2836:Salk
2816:Mpox
2762:LAIV
2757:H5N1
2747:H1N1
2623:PPSV
2506:ACIP
2502:US:
2476:SAGE
2437:mRNA
2353:list
1780:PMID
1751:PMID
1710:PMID
1669:PMID
1618:PMID
1561:PMID
1510:PMID
1412:PMID
1381:2023
1353:2021
1326:2021
1300:2021
1274:2019
1252:2019
1225:PMID
1165:2015
1134:2013
1108:2015
1082:2016
1044:PMID
1005:PMID
958:2023
924:PMID
860:PMID
802:PMID
780:2006
753:PMID
731:2006
704:PMID
626:2023
595:2023
558:2021
532:2021
493:and
472:and
149:UNII
3289:MMR
3132:HPV
3122:BCG
3023:HIV
2983:MMR
2789:HPV
2742:Flu
2645:BCG
2618:PCV
2571:Hib
2526:VSD
2433:DNA
2328:J07
1989:DDT
1772:doi
1743:doi
1700:doi
1659:PMC
1649:doi
1608:PMC
1600:doi
1551:PMC
1541:doi
1500:PMC
1492:doi
1488:386
1451:doi
1404:doi
1400:402
1215:doi
1211:387
1036:doi
995:PMC
985:doi
981:367
914:PMC
906:doi
902:124
852:doi
792:PMC
784:doi
743:PMC
735:doi
694:PMC
686:doi
682:366
587:NPR
487:in
3436::
3387::
2435:/
2426:/
2422:/
2418:/
2322:,
2318:,
2314:,
2310::
2306:/
1786:.
1778:.
1768:46
1766:.
1749:.
1739:11
1737:.
1708:.
1696:13
1694:.
1690:.
1667:.
1657:.
1645:11
1643:.
1639:.
1616:.
1606:.
1598:.
1586:.
1582:.
1559:.
1549:.
1537:12
1535:.
1531:.
1508:.
1498:.
1486:.
1482:.
1459:.
1445:.
1441:.
1418:.
1410:.
1398:.
1369:.
1291:.
1223:.
1209:.
1205:.
1186:.
1155:.
1151:.
1125:.
1073:.
1050:.
1042:.
1032:10
1030:.
1026:.
1003:.
993:.
979:.
975:.
949:.
936:^
922:.
912:.
900:.
896:.
884:^
874:.
866:.
858:.
848:23
846:.
842:.
828:^
800:.
790:.
778:.
774:.
751:.
741:.
729:.
725:.
702:.
692:.
680:.
676:.
657:.
614:.
603:^
585:.
566:^
548:.
522:.
511:^
341:.
263:.
3412::
3298:)
3291:(
2753:)
2749:(
2330:)
2326:(
2296:e
2289:t
2282:v
1840:e
1833:t
1826:v
1794:.
1774::
1757:.
1745::
1716:.
1702::
1675:.
1651::
1624:.
1602::
1594::
1588:8
1567:.
1543::
1516:.
1494::
1467:.
1453::
1447:6
1426:.
1406::
1383:.
1355:.
1328:.
1302:.
1276:.
1254:.
1231:.
1217::
1167:.
1136:.
1110:.
1084:.
1058:.
1038::
1011:.
987::
960:.
930:.
908::
854::
822:.
808:.
786::
759:.
737::
710:.
688::
661:.
642:.
628:.
597:.
560:.
534:.
466:E
426:)
422:(
418:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
