1041:
619:
1003:
815:
63:
627:
611:
474:
929:
2151:
674:(accessed 3/3/16). At least seven of the Molecule-of-the-Month features at the RCSB site of the worldwide Protein Databank have featured molecular structures solved and studied by the Blundell lab, such as the glucagon hormone shown at left in
559:. His speciality is molecular biology and his research on identifying the chemical processes of diseases has led to the development of drugs to treat Aids, cancer, cataracts and diabetes. He is the co-founder of two drug discovery companies,
778:
from mammals and fungi and the proteins of the eye lens is characterised by similar extensive detail from which he disects important structural relationships and derives principles and guides on protein evolution and hormone (especially
850:, Royal Society 1998. He received the 2013 Biochemical Society Award and Cambridge University Science Prize called the Philosophical Society Fellows Prize & Lecture 2014. Most recently in 2017 he received the 11th
1597:
McDonald, Neil Q.; Lapatto, Risto; Rust, Judith Murray; Gunning, Jennifer; Wlodawer, Alexander; Blundell, Tom L. (1991). "New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor".
769:
to receptor binding of this hormone. In chemically modified insulins he has studied structure-function relationships and he has proposed a model for the evolution of insulin. His work on avian pancreatic
2139:
646:, with the objectives of understanding biological function, of knowledge-based prediction of structure, and of discovering new therapeutics for cancer and tuberculosis. Systems studied include
2388:
1021:
The
Determination by X-Ray diffraction methods of the crystal and molecular structures of some co-ordination compounds : a study of the stereochemistry of pentaco-ordination
2413:
2403:
742:
Professor of
Crystallography, Birkbeck College, University of London. Distinguished for his work on crystal and molecular structures and biochemistry of protein
1246:; Cutfield, J.; Cutfield, S.; Dodson, E.; Dodson, G.; Hodgkin, D.; Mercola, D.; Vijayan, M. (1971). "Atomic positions in rhombohedral 2-zinc insulin crystals".
2325:
2019:; Mizuguchi, K. (2001). "FUGUE: Sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties".
537:
276:
872:
Blundell's contributions were recognised by a knighthood in 1997. He has been awarded
Honorary Doctorate degrees from 16 universities and was interviewed by
1301:
2262:
2438:
2383:
2363:
735:
2428:
1682:
Pellegrini L, Yu DS, Anand S, Lee M, Blundell TL, Venkitaraman AR (2002). "Insights into DNA recombination from the structure of a RAD51-BRCA2 complex".
634:
Blundell's research interests lie in elucidating the architecture and function of macromolecules and their multi-component assemblies using methods from
2398:
583:(1970–73), during the time when it stopped the building of a motorway through the city centre, pedestrianised much of the historic centre, and made
1558:
2433:
827:
588:
2290:
1507:
Sasaki K, Dockerill, Adamiak DA, Tickle IJ, Blundell TL (1975). "X-ray analysis of glucagon and its relationship to receptor binding".
548:
397:
44:
393:
40:
1760:"Structure of the catalytic region of DNA ligase IV in complex with an artemis fragment sheds light on double-strand break repair"
972:
792:
532:
In 1991, while continuing academic research, he moved further into science administration and policy, as
Director General of the
1850:"Genome3D: A UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains"
533:
281:
48:
2418:
2393:
906:
2368:
2173:
1348:
303:
The determination by X-ray diffraction methods of the crystal and molecular structures of some co-ordination compounds
1493:
556:
1909:; Minneci, F; Mistry, J; Murzin, A. G.; Ochoa-Montaño, B; Oates, M. E.; Punta, M; Rackham, O. J.; Stahlhacke, J;
1414:
804:
401:
52:
2378:
2120:
555:; he currently also holds the Chair of the School of Biological Sciences at that university. He is a fellow of
526:
271:
2237:
2423:
808:
450:
2373:
1379:
1352:
894:
Blundell married Lady
Bancinyane Lynn Sibanda in 1987 and has three children. His brother is the economist
839:
461:. Blundell has played central roles in restructuring British research councils and, as President of the UK
441:, and familial diseases. He has developed software for protein modelling and understanding the effects of
1019:
800:
788:
686:
DNA recombination complex, and the DNA ligase shown at right. His group has written several broadly used
389:
302:
36:
1465:
566:
On 15 September 2010, Blundell, along with 54 other public figures, signed an open letter published in
2408:
2199:
2054:
Pandurangan, Arun Prasad; Ochoa-Montaño, Bernardo; Ascher, David B.; Blundell, Tom L. (3 July 2017).
1040:
1902:
1837:
502:
17:
579:
Blundell has been active on environmental issues, first as Chair of the
Planning Committee of the
2335:
1214:
914:
707:
552:
482:
256:
105:
1328:
938:
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858:
826:
Award for Vision
Research in 1986; Gold Medal, Institute of Biotechnology in 1987; Krebs Medal
541:
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1203:
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1170:
1155:
2358:
2294:
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1607:
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1255:
703:
522:
510:
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486:
266:
261:
115:
1133:
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1061:
485:. He was the first in his family to attend university, winning an Open Scholarship to the
8:
1222:
1002:
994:
910:
902:
882:
862:
831:
659:
580:
426:
1695:
1611:
1520:
1259:
934:
2238:"Kirsty Young's castaway this week is the leading scientist Professor Sir Tom Blundell"
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2055:
1992:
1967:
1939:
1914:
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1715:
1639:
1540:
1506:
1279:
225:
1844:; Minneci, F; Mitchell, A; Murzin, A. G.; Ochoa-Montaño, B; Rackham, O. J.; Smith, J;
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1997:
1944:
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762:
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1999. International recognition has come in his election as a
Foreign Member of the
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1987:
1979:
1934:
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1779:
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1388:
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895:
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314:
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409:, structural biologist, and science administrator. He was a member of the team of
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866:
723:
639:
506:
494:
462:
410:
345:
201:
189:
618:
1377:(1993). "Comparative Protein Modelling by Satisfaction of Spatial Restraints".
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Protein structure prediction: amino acid propensities and comparative modelling
1135:
Modelling three-dimensional structure of a protein from its amino acid sequence
998:
847:
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780:
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655:
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458:
363:
335:
240:
230:
1968:"HOMSTRAD: A database of protein structure alignments for homologous families"
1775:
1115:
814:
719:
601:
Turning the Tide: Addressing the Impact of
Fisheries on the Marine Environment
340:
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2147:
2079:
1898:
1833:
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1147:
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and HIV protease. He has contributed 235 crystal structures to the worldwide
422:
417:. Blundell has made contributions to the structural biology of polypeptide
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1983:
1948:
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62:
2001:
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1635:
1494:"British Humanist Association – Distinguished supporters:Sir Tom Blundell"
1400:
1275:
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2071:
1930:
1915:"Genome3D: Exploiting structure to help users understand their sequences"
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877:
854:
771:
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330:
195:
139:
2223:
2056:"SDM: a server for predicting effects of mutations on protein stability"
1897:
Lewis, T. E.; Sillitoe, I; Andreeva, A; Blundell, T. L.; Buchan, D. W.;
1832:
Lewis, T. E.; Sillitoe, I; Andreeva, A; Blundell, T. L.; Buchan, D. W.;
1703:
1302:"The multi-talented scientist who finds inspiration in far-flung places"
663:
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430:
406:
2053:
626:
1619:
1528:
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597:
Chemicals in
Products – Safeguarding the Environment and Human Health
442:
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programs. He co-authored a textbook on protein crystallography with
610:
544:(2004–06). In June 2011 he became President of the Science Council.
775:
766:
651:
93:
1733:
1572:
473:
1807:
1657:
818:
Sir Tom Blundell in his office at the University of Cambridge, UK
759:
751:
743:
591:, when he oversaw the production of key reports such as those on
446:
418:
414:
134:
1961:
822:
Blundell has received numerous awards and medals, including the
614:
Original 1989 structure of the HIV protease dimer, from PDB 3PHV
525:. In 1976, Blundell joined the Department of Crystallography at
521:
Blundell's early posts were at the University of Oxford and the
1332:
843:
747:
434:
296:
2263:"Prof. Tom Blundell: A Personal History of Science and Ethics"
1242:
1063:
The design, expression and characterisation of a novel protein
493:
in 1964, then moved to research in the Department of Chemical
413:
that solved in 1969 the first structure of a protein hormone,
1896:
1831:
1176:
1151:
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823:
683:
679:
667:
560:
454:
286:
129:
465:, in developing professionalism in the practice of science.
449:
function, leading to new approaches to structure-guided and
2389:
Fellows of the Academy of Medical Sciences (United Kingdom)
851:
587:
a conservation area. From 1998 to 2005 he was Chair of the
1596:
1440:
536:(1991–94) and then the founding Chief Executive of the
2414:
Members of the European Molecular Biology Organization
2404:
Foreign fellows of the Indian National Science Academy
2326:
Biotechnology and Biological Sciences Research Council
538:
Biotechnology and Biological Sciences Research Council
277:
Biotechnology and Biological Sciences Research Council
622:
Glucagon hormone (red) bound to its membrane receptor
540:(BBSRC) (1994–1996). He is a former president of the
2014:
1681:
1590:
1415:"Letters: Harsh judgments on the pope and religion"
481:Born in Brighton in 1942, Blundell was educated at
2174:"The Academy of Medical Sciences | Directory"
1202:
551:and head of the Department of Biochemistry at the
697:
2345:
787:Blundell became one of the first fellows of the
758:. He had an outstanding part in solution of the
694:, which was translated into French and Russian.
2110:
497:, first with Herbert Marcus Powell FRS for his
2192:
1757:
1441:"Royal Commission on Environmental Pollution"
838:in Biology and Medicine in 1988; Gold Medal,
453:. In 1999 he co-founded the oncology company
2225:T. Blundell awarded the eleventh Ewald Prize
1557:: CS1 maint: multiple names: authors list (
1372:
1052:
1050:
2439:Sir William Dunn Professors of Biochemistry
2384:Fellows of Sidney Sussex College, Cambridge
2364:Academics of Birkbeck, University of London
1848:; Velankar, S; Yeats, C; Orengo, C (2013).
589:Royal Commission on Environmental Pollution
2429:People educated at Steyning Grammar School
2291:Sir William Dunn Professor of Biochemistry
1840:; Hunter, S; Jones, D. T.; Kelley, L. A.;
1300:Cambridge, University of (29 March 2018).
1103:Crystallographic studies of endothiapepsin
1095:
1093:
1001:
846:European Prize for Innovation in 1998 and
549:Sir William Dunn Professor of Biochemistry
61:
2399:Fellows of the Royal Society of Chemistry
2087:
1991:
1938:
1901:; Cozzetto, D; Dana, J. M.; Filippis, I;
1873:
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1324:
1322:
1299:
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1293:
1196:
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1125:
1047:
736:Fellow of the Royal Society (FRS) in 1984
501:degree and later working on insulin with
2200:"Past medals, awards and prize lectures"
2133:
2131:
1349:"Professor Sir Tom Blundell FRS FMedSci"
1142:(PhD thesis). London, Birkbeck College.
1110:(PhD thesis). London, Birkbeck College.
1017:
1013:
1011:
813:
791:in 1998. He was elected a member of the
625:
617:
609:
472:
2140:"EC/1984/03: Blundell, Sir Thomas Leon"
1217: ed.). A & C Black.
1090:
1056:
973:European Molecular Biology Organization
958:
956:
793:European Molecular Biology Organisation
529:, becoming head of department in 1978.
2346:
1734:"RecA and Rad51 Molecule-of-the-Month"
1319:
1290:
1204:"Blundell, Sir Thomas Leon, (Sir Tom)"
1187:
1122:
1028:(DPhil thesis). University of Oxford.
534:Agricultural and Food Research Council
516:
513:, where he is now an Honorary Fellow.
282:Agricultural and Food Research Council
2128:
1836:; Cuff, A; Dana, J. M.; Filippis, I;
1658:"Neurotrophins Molecule-of-the-Month"
1168:
1099:
1008:
729:
678:'s drawing, nerve growth factor, the
505:. He was a Junior Research Fellow at
2154:from the original on 16 January 2016
2137:
1466:"Turning the Tide (RCEP report #25)"
1200:
1162:
1131:
1070:(PhD thesis). University of London.
990:
988:
986:
984:
982:
962:
953:
489:. He earned a First Class degree in
2434:Alumni of Brasenose College, Oxford
765:. He has related his structure for
658:and hormone/receptor interactions,
630:Human DNA ligase IV, from PDB 3W5O.
16:For the New Zealand cricketer, see
13:
1808:"DNA ligase Molecule-of-the-Month"
1758:Ochi T, Gu X, Blundell TL (2013).
1223:10.1093/ww/9780199540884.013.U7914
603:. He is a Distinguished Member of
14:
2450:
1913:; Velankar, S; Orengo, C (2015).
979:
702:Blundell has supervised numerous
457:, which has moved ten drugs into
2111:Blundell TL, Johnson LN (1976),
1573:"Glucagon Molecule-of-the-Month"
1039:
927:
889:
795:(EMBO) in 1985; A member of the
405:(born 7 July 1942) is a British
2255:
2230:
2217:
2166:
2104:
2047:
2008:
1955:
1905:; Jones, D. T.; Kelley, L. A.;
1890:
1825:
1800:
1751:
1726:
1675:
1650:
1565:
1500:
1486:
1458:
1433:
1407:
1366:
1341:
865:(2009–2011); and President, UK
805:Indian National Science Academy
164:
1236:
698:Doctoral students and postdocs
572:, stating their opposition to
527:Birkbeck, University of London
431:DNA double-strand break repair
272:Birkbeck, University of London
1:
1962:Mizuguchi, K.; Deane, C. M.;
920:
809:The World Academy of Sciences
593:Energy – the Changing Climate
451:Fragment-based lead discovery
2419:Members of Academia Europaea
2394:Fellows of the Royal Society
2021:Journal of Molecular Biology
1966:; Overington, J. P. (1998).
1860:(Database issue): D499-507.
1380:Journal of Molecular Biology
1353:British Humanist Association
1331:publications indexed by the
1230:UK public library membership
1058:Hubbard, Timothy John Philip
901:Blundell was elected to the
857:. He has been President, UK
840:Society of Chemical Industry
547:In 1995 he became the fifth
468:
154:Lady Bancinyane Lynn Sibanda
7:
1421:. London. 15 September 2010
801:Academy of Medical Sciences
789:Academy of Medical Sciences
10:
2455:
1925:(Database issue): D382-6.
842:in 1996; First Recipient,
807:, the Chilean Academy and
799:in 1993; Founding Member,
576:'s state visit to the UK.
15:
2369:British bioinformaticians
2332:
2322:
2316:
2311:
2301:
2288:
2280:
2275:
1776:10.1016/j.str.2013.02.014
1169:Deane, Charlotte (2000).
358:
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323:
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249:
218:
211:
182:
174:
148:
122:
111:
101:
72:
60:
30:
1335:bibliographic database.
1100:Pearl, Laurence (1991).
997:publications indexed by
861:(2003–2009); President,
738:. His nomination reads:
708:postdoctoral researchers
433:, subjects important in
385:Sir Thomas Leon Blundell
18:Tom Blundell (cricketer)
2113:Protein Crystallography
1337:(subscription required)
1215:Oxford University Press
734:Blundell was elected a
640:protein crystallography
553:University of Cambridge
483:Steyning Grammar School
425:, receptor activation,
257:University of Cambridge
106:Steyning Grammar School
2060:Nucleic Acids Research
2033:10.1006/jmbi.2001.4762
1984:10.1002/pro.5560071126
1919:Nucleic Acids Research
1854:Nucleic Acids Research
1393:10.1006/jmbi.1993.1626
1018:Blundell, Tom (1967).
859:Biosciences Federation
819:
785:
631:
623:
615:
542:Biosciences Federation
478:
2379:English biophysicists
1132:Sali, Andrej (1991).
817:
740:
710:in his lab including
629:
621:
613:
557:Sidney Sussex College
476:
2424:People from Brighton
2295:Cambridge University
704:Doctor of Philosophy
563:Ltd and Biofabrika.
523:University of Sussex
511:University of Oxford
499:Doctor of Philosophy
487:University of Oxford
267:University of Sussex
262:University of Oxford
204:from 16 universities
116:University of Oxford
77:Thomas Leon Blundell
2374:British biochemists
2312:Government offices
1866:10.1093/nar/gks1266
1704:10.1038/nature01230
1696:2002Natur.420..287P
1612:1991Natur.354..411M
1521:1975Natur.257..751S
1260:1971Natur.231..506B
913:councillor for the
903:Oxford City Council
883:Desert Island Discs
863:Biochemical Society
832:Biochemical Society
660:cellular signalling
581:Oxford City Council
517:Career and research
427:signal transduction
202:Honorary Doctorates
2115:, Academic Press,
2072:10.1093/nar/gkx439
1931:10.1093/nar/gku973
1181:uk.bl.ethos.598479
1156:uk.bl.ethos.415316
937:has a profile for
830:1987; Ciba Medal,
820:
730:Awards and honours
632:
624:
616:
479:
455:Astex Therapeutics
226:Structural biology
23:British biochemist
2342:
2341:
2333:Succeeded by
2302:Succeeded by
2276:Academic offices
2180:on 1 October 2006
2066:(W1): W229–W235.
1978:(11): 2469–2471.
1690:(6913): 287–293.
1606:(6352): 411–414.
1515:(5529): 751–757.
1254:(5304): 506–511.
1228:(Subscription or
965:"Tom L. Blundell"
943:
797:Academia Europaea
763:crystal structure
672:Protein Data Bank
666:(lens proteins),
574:Pope Benedict XVI
382:
381:
324:Doctoral students
213:Scientific career
135:Insulin structure
2446:
2409:Knights Bachelor
2317:Preceded by
2281:Preceded by
2273:
2272:
2267:
2266:
2259:
2253:
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2250:
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2234:
2228:
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2215:
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2204:royalsociety.org
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2176:. Archived from
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2144:royalsociety.org
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2101:
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2012:
2006:
2005:
1995:
1959:
1953:
1952:
1942:
1911:Sternberg, M. J.
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1846:Sternberg, M. J.
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1006:
1005:
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896:Richard Blundell
561:Astex Technology
491:Natural Sciences
404:
378:
375:
373:
371:
369:
367:
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319:Herbert M Powell
315:Doctoral advisor
309:
168:
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90:
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84:
67:Blundell in 2006
65:
55:
32:Sir Tom Blundell
28:
27:
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2017:Blundell, T. L.
2013:
2009:
1972:Protein Science
1964:Blundell, T. L.
1960:
1956:
1907:Kleywegt, G. J.
1895:
1891:
1842:Kleywegt, G. J.
1830:
1826:
1816:
1814:
1812:Pdb101.rcsb.org
1806:
1805:
1801:
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1738:Pdb101.rcsb.org
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1662:Pdb101.rcsb.org
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1577:Pdb101.rcsb.org
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1412:
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1375:Blundell, T. L.
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892:
867:Science Council
732:
724:Charlotte Deane
700:
519:
507:Linacre College
503:Dorothy Hodgkin
495:Crystallography
477:Insulin monomer
471:
463:Science Council
459:clinical trials
411:Dorothy Hodgkin
388:
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350:
346:Charlotte Deane
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848:Bernal Lecture
836:Feldberg Prize
781:growth hormone
731:
728:
716:Laurence Pearl
699:
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692:Louise Johnson
688:bioinformatics
676:David Goodsell
656:growth factors
644:bioinformatics
518:
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2138:Anon (1984).
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1932:
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963:Anon (1996).
959:
957:
952:
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940:Tom Blundell
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915:St. Clement’s
912:
908:
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890:Personal life
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2241:
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2168:
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2143:
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2020:
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1661:
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1512:
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1472:
1460:
1448:. Retrieved
1444:
1435:
1425:16 September
1423:. Retrieved
1419:The Guardian
1418:
1409:
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1368:
1356:. Retrieved
1343:
1329:Tom Blundell
1309:. Retrieved
1305:
1251:
1247:
1244:Blundell, T.
1243:
1238:
1208:
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1140:london.ac.uk
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1108:london.ac.uk
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900:
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600:
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585:North Oxford
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569:The Guardian
567:
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520:
480:
439:tuberculosis
384:
383:
301:
250:Institutions
236:Biochemistry
212:
25:
2359:1942 births
2324:CEO of the
2305:Gerard Evan
1473:Rcep.org.uk
1445:Rcep.org.uk
878:BBC Radio 4
855:Ewald Prize
783:) function.
776:proteinases
774:, the acid
772:polypeptide
720:Andrej Šali
712:Tim Hubbard
664:crystallins
341:Andrej Šali
331:Tim Hubbard
196:EMBO Member
140:Drug design
118:(BA, DPhil)
87:7 July 1942
2348:Categories
2330:1994–1996
2299:1995–2009
2146:. London:
2122:0121083500
1899:Chothia, C
1834:Chothia, C
1373:Šali, A.;
1306:Medium.com
1232:required.)
1116:1000934521
942:(Q7814993)
921:References
880:programme
648:DNA repair
407:biochemist
83:1942-07-07
2336:Ray Baker
2242:Bbc.co.uk
2209:4 October
2184:6 January
2080:0305-1048
2015:Shi, J.;
1764:Structure
1628:0028-0836
1210:Who's Who
1148:500526292
1076:940320228
886:in 2007.
834:in 1988;
469:Education
443:mutations
376:/blundell
374:/research
102:Education
2152:Archived
2098:28525590
2041:11419950
1949:25348407
1903:Gough, J
1884:23203986
1838:Gough, J
1794:23523427
1712:12442171
1358:22 March
1213:(online
1084:29528696
1060:(1988).
1034:34750152
767:glucagon
756:eye lens
752:proteins
744:hormones
652:hormones
419:hormones
175:Children
94:Brighton
2158:13 June
2089:5793720
2002:9828015
1993:2143859
1940:4384030
1875:3531217
1785:3664939
1720:4359383
1692:Bibcode
1644:4346788
1636:1956407
1608:Bibcode
1545:4183707
1517:Bibcode
1401:8254673
1284:4158731
1276:4932997
1256:Bibcode
935:Scholia
876:on the
760:insulin
754:of the
748:enzymes
447:protein
415:insulin
398:FMedSci
359:Website
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911:Labour
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297:Thesis
219:Fields
198:(1986)
192:(1997)
183:Awards
149:Spouse
1716:S2CID
1640:S2CID
1541:S2CID
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1280:S2CID
1177:EThOS
1152:EThOS
1080:Copac
1030:Copac
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1559:link
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1272:PMID
1144:OCLC
1112:OCLC
1072:OCLC
907:1970
852:IUCr
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394:FRSC
368:.cam
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