613:
590:
51:
1117:. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.
893:
42:
6726:
864:
pemetrexed). Overall response rate is about 50% better than standard second-line chemotherapy. Patients who are non-smokers, and light former smokers, with adenocarcinoma or subtypes like BAC are more likely to have EGFR mutations, but mutations can occur in all types of patients. A test for the EGFR mutation has been developed by
908:, patients rapidly develop resistance. In the case of erlotinib this typically occurs 8–12 months from the start of treatment. Over 50% of resistance is caused by a mutation in the ATP binding pocket of the EGFR kinase domain involving substitution of a small polar threonine residue with a large nonpolar methionine residue (
944:
occurs in the majority of patients. This resembles acne and primarily involves the face and neck. It is self-limited and resolves in the majority of cases, even with continued use. Some clinical studies have indicated a correlation between the severity of the skin reactions and increased survival
863:
In lung cancer, erlotinib has been shown to be effective in patients with or without EGFR mutations, but appears to be more effective in patients with EGFR mutations. Overall survival, progression-free survival and one-year survival are similar to standard second-line therapy (docetaxel or
1829:
Dudek AZ, Kmak KL, Koopmeiners J, Keshtgarpour M (January 2006). "Skin rash and bronchoalveolar histology correlates with clinical benefit in patients treated with gefitinib as a therapy for previously treated advanced or metastatic non-small cell lung cancer".
1140:
The drug's U.S. patent expired in 2020. In May 2012, the US District Court of
Delaware passed an order in favor of OSI Pharmaceutical LLC against Mylan Pharmaceuticals upholding the validity of the patent for Erlotinib. In India, generic pharmaceutical firm
953:
reported in its
October 2003 issue, "Patients with moderate to severe cutaneous reactions have a far better survival, than those with only mild reactions and much better than those with no cutaneous manifestations of drug
1575:"Comparison of the efficacy and safety of EFGR tyrosine kinase inhibitor monotherapy with standard second-line chemotherapy in previously treated advanced non-small-cell lung cancer: a systematic review and meta-analysis"
2302:
1355:"2009 - SATURN: A double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with first-line platinum-based chemotherapy in patients with advanced NSCLC"
1354:
2220:
228:
6003:
2272:
949:
reported in 2004 that "cutaneous rash seems to be a surrogate marker of clinical benefit, but this finding should be confirmed in ongoing and future studies." The newsletter
6023:
2361:
1230:
6013:
3792:
2294:
4168:
821:
1674:"Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors"
6796:
5998:
1651:
183:
4533:
1309:
1041:
5768:
3843:
2354:
724:
InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
5707:
4884:
4076:
3785:
1358:
6667:
4809:
6761:
6391:
6304:
6249:
6203:
6148:
5883:
5823:
4824:
4754:
4313:
3911:
3853:
2795:
2780:
81:
2212:
1387:
6791:
6386:
6264:
6163:
5949:
5838:
5638:
5598:
5346:
5265:
5127:
5068:
5030:
4975:
4970:
4960:
4834:
4829:
4799:
4774:
4769:
4759:
4645:
4564:
4503:
4431:
4410:
4395:
4348:
4001:
1622:
696:
6486:
6344:
6323:
6279:
6259:
6178:
6158:
5873:
5853:
5833:
5476:
5471:
4804:
4528:
4061:
3858:
2347:
1772:"MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib"
6309:
6299:
6254:
6208:
6198:
6153:
5977:
5944:
5924:
5888:
5878:
5828:
5788:
5260:
5240:
5207:
5088:
4990:
4839:
3778:
2264:
6269:
6168:
6063:
5967:
5919:
5912:
5898:
5843:
5813:
5293:
5283:
5235:
5217:
5146:
4980:
4819:
4764:
682:
6008:
5698:
5303:
5020:
3353:
2996:
1220:
785:
Common side effects include rash, diarrhea, muscle pain, joint pain, and cough. Serious side effects may include lung problems,
6108:
4288:
3971:
2242:
1927:"Cytochrome P450-mediated bioactivation of the epidermal growth factor receptor inhibitor erlotinib to a reactive electrophile"
6766:
6686:
6636:
6607:
6554:
5041:
4908:
1275:
1170:
6365:
6361:
6357:
6353:
3906:
3890:
2489:
2328:
1906:
Petty TL (2003). "Determinants of Tumor
Response and Survival With Erlotinib in Patients With Non—Small-Cell Lung Cancer".
1113:(ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a
4634:
4553:
4420:
4337:
1523:"Epidermal growth factor receptor (EGFR) mutation and personalized therapy in advanced nonsmall cell lung cancer (NSCLC)"
6349:
3467:
1001:
6038:
5157:
4717:
4328:
1415:
Gijtenbeek RG, van der Noort V, Aerts JG, Staal-van den Brekel JA, Smit EF, Krouwels FH, et al. (October 2022).
741:
716:
132:
1645:
3986:
3930:
3921:
2887:
2413:
1098:
814:
771:
6560:
355:
213:
113:
6647:
6623:
5763:
5319:
5182:
438:
6613:
1297:
6657:
5053:
4935:
4925:
3233:
1303:
1014:
905:
846:
794:
608:
489:
6781:
6028:
3414:
2390:
1867:"Determinants of tumor response and survival with erlotinib in patients with non--small-cell lung cancer"
569:
2339:
6716:
6642:
4468:
3539:
3388:
3137:
2639:
1018:
853:
763:
1615:"Roche obtains license for EGFR lung cancer assays and will develop Tarceva companion diagnostic test"
558:
6776:
6550:
2864:
2730:
2443:
1195:
1053:
842:
810:
1614:
6751:
4734:
4650:
4569:
4436:
4353:
2874:
2400:
1865:
Pérez-Soler R, Chachoua A, Hammond LA, Rowinsky EK, Huberman M, Karp D, et al. (August 2004).
1102:
1036:
585:
6334:
4081:
3956:
2370:
1380:
988:. This may be severe and must be considered among those patients whose breathing acutely worsens.
774:(EGFR) — either an exon 19 deletion (del19) or exon 21 (L858R) substitution mutation — which has
169:
63:
17:
6771:
6618:
6234:
6138:
5758:
5177:
4163:
3801:
3242:
2725:
2454:
1110:
1070:(OATP1B1 or OATP1B3). Also, erlotinib is not an inhibitor of OATP-1B1 or OATP-1B3 transporter.
538:
282:
1715:"MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling"
6801:
6786:
6692:
4889:
4173:
3812:
2800:
2740:
2710:
2613:
2449:
1134:
429:
478:
393:
6632:
6018:
4950:
4899:
2655:
2550:
2387:
1783:
1726:
1713:
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, et al. (May 2007).
1078:
498:
313:
8:
5773:
5187:
3508:
2775:
2765:
2585:
1130:
837:
Erlotinib in unresectable non-small cell lung cancer when added to chemotherapy improves
384:
1787:
1730:
612:
589:
5451:
3804:
3163:
2700:
2159:
2090:
2065:
2041:
2017:"Role of OATP-1B1 and/or OATP-1B3 in hepatic disposition of tyrosine kinase inhibitors"
2016:
1951:
1926:
1806:
1771:
1752:
1672:
Balak MN, Gong Y, Riely GJ, Somwar R, Li AR, Zakowski MF, et al. (November 2006).
1547:
1522:
1503:
1449:
1416:
1047:
965:
802:
143:
6078:
2840:
2194:
2190:
2151:
2146:
2130:"Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy"
2129:
2095:
2046:
1997:
1956:
1888:
1847:
1811:
1744:
1695:
1596:
1552:
1495:
1454:
896:
Erlotinib bound to ErbB1 at 2.6A resolution; surface colour indicates hydrophobicity.
881:
767:
254:
241:
105:
3770:
2250:
2177:
Adis
International Ltd (2003). "Erlotinib: CP 358774, NSC 718781, OSI 774, R 1415".
2163:
1756:
1507:
1081:, can lower erlotinib concentrations, while inhibitors can increase concentrations.
6496:
5628:
2680:
2522:
2517:
2186:
2141:
2085:
2077:
2036:
2028:
1987:
1946:
1938:
1878:
1839:
1801:
1791:
1770:
Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, et al. (December 2007).
1734:
1685:
1586:
1542:
1534:
1490:
1485:
1473:
1444:
1436:
1336:
625:
418:
264:
196:
1843:
1690:
1673:
1591:
1574:
820:
Erlotinib was approved for medical use in the United States in 2004. It is on the
6756:
6746:
6730:
1267:
1162:
900:
As with other ATP competitive small molecule tyrosine kinase inhibitors, such as
786:
292:
272:
91:
2213:"FDA Approves Roche Test as CDx for Tarceva for Treating Certain NSCLC Patients"
1440:
1414:
6682:
6603:
6545:
6239:
6088:
6083:
5197:
5192:
3838:
3828:
3823:
3617:
3515:
3463:
3061:
2374:
1776:
Proceedings of the
National Academy of Sciences of the United States of America
1090:
1538:
1097:), which was the first drug of this type. Erlotinib specifically targets the
1077:. Compounds which induce this enzyme (i.e. stimulate its production), such as
6740:
6376:
6289:
6218:
6188:
6123:
6033:
5987:
5863:
5793:
5738:
5727:
5212:
4920:
4603:
4508:
4400:
3674:
3564:
3526:
3503:
3435:
3430:
3420:
3196:
3192:
3180:
2987:
2770:
2735:
2555:
2535:
991:
838:
790:
601:
1976:"Fatal asymmetric interstitial lung disease after erlotinib for lung cancer"
1883:
1866:
1796:
1739:
1714:
6702:
6672:
6411:
6401:
6294:
6193:
6048:
5868:
5803:
5718:
5222:
5025:
4864:
4859:
4779:
4729:
4543:
4297:
4278:
4257:
4228:
3951:
3946:
3714:
3699:
3669:
3649:
3531:
3479:
3440:
3328:
3307:
3214:
3176:
3077:
3052:
3048:
2932:
2897:
2850:
2835:
2790:
2665:
2635:
2560:
2378:
2198:
2155:
2117:(in German) (2010/2011 ed.). Vienna: Österreichischer Apothekerverlag.
2099:
2081:
2050:
2032:
2001:
1960:
1942:
1892:
1851:
1815:
1748:
1699:
1600:
1556:
1499:
1458:
1417:"Randomised controlled trial of first-line tyrosine-kinase inhibitor (TKI)
1333:
World Health
Organization model list of essential medicines: 21st list 2019
857:
191:
2295:"Cancer drug: Supreme Court allows Cipla to withdraw appeal against Roche"
50:
33:
6662:
6628:
6526:
6516:
6511:
6501:
6451:
6274:
6173:
5934:
5848:
5778:
5673:
5436:
5401:
5351:
5314:
5250:
5132:
5063:
5015:
5005:
5000:
4995:
4879:
4874:
4869:
4247:
4158:
4148:
4116:
4111:
4106:
4101:
4091:
4051:
4016:
3744:
3724:
3719:
3709:
3689:
3664:
3659:
3642:
3590:
3580:
3575:
3570:
3472:
3399:
3369:
3364:
3359:
3343:
3333:
3313:
3188:
3184:
3172:
3168:
3097:
3001:
2947:
2942:
2907:
2845:
2830:
2820:
2815:
2810:
2805:
2785:
2750:
2705:
2685:
2675:
2630:
2595:
2575:
2531:
2494:
2482:
2477:
2439:
2423:
2369:
981:
877:
99:
1340:
458:
6481:
6446:
6441:
6431:
6421:
6339:
6128:
6103:
6093:
5939:
5893:
5753:
5579:
5548:
5517:
5486:
5431:
5406:
5386:
5371:
5361:
5255:
5172:
4965:
4945:
4844:
4789:
4784:
4608:
4513:
4498:
4293:
4252:
4224:
4193:
4153:
4056:
4011:
4006:
3981:
3976:
3966:
3879:
3873:
3863:
3759:
3754:
3729:
3694:
3679:
3654:
3637:
3627:
3585:
3556:
3521:
3487:
3404:
3394:
3374:
3338:
3323:
3318:
3288:
3222:
3218:
3200:
3148:
3127:
3087:
3082:
3021:
2952:
2927:
2902:
2825:
2760:
2720:
2715:
2695:
2690:
2670:
2660:
2650:
2565:
2545:
2527:
2435:
915:
Approximately 20% of drug resistance is caused by amplification of the
850:
775:
759:
658:
469:
1992:
1975:
6506:
6476:
6471:
6466:
6461:
6456:
6436:
6426:
6416:
6406:
6098:
6058:
5954:
5929:
5688:
5683:
5678:
5668:
5663:
5658:
5648:
5569:
5507:
5441:
5421:
5416:
5411:
5396:
5391:
5381:
5376:
5270:
5245:
5010:
4930:
4849:
4794:
4684:
4623:
4613:
4518:
4405:
4203:
4198:
4188:
4096:
4086:
4071:
4046:
4041:
4031:
4026:
3749:
3739:
3734:
3704:
3684:
3632:
3622:
3610:
3605:
3551:
3546:
3492:
3425:
3298:
3293:
3278:
3273:
3268:
3258:
3253:
3248:
3153:
3143:
3122:
3117:
3112:
3107:
3102:
3092:
3072:
3036:
3031:
3026:
3016:
3011:
2978:
2973:
2968:
2937:
2917:
2755:
2745:
2570:
2418:
1126:
1114:
1109:
in various forms of cancer. It binds in a reversible fashion to the
1094:
806:
404:
330:
85:
6677:
6396:
6053:
5653:
5643:
5623:
5366:
5356:
4703:
4183:
4126:
4036:
3996:
3499:
3263:
3067:
3006:
2962:
2922:
2892:
2645:
2509:
2505:
2430:
2066:"Inhibition of OATP-1B1 and OATP-1B3 by tyrosine kinase inhibitors"
1573:
Qi WX, Shen Z, Lin F, Sun YJ, Min DL, Tang LN, et al. (2012).
1472:
Cohen MH, Johnson JR, Chen YF, Sridhara R, Pazdur R (August 2005).
1225:
1106:
957:
901:
779:
518:
449:
176:
127:
5558:
5527:
5496:
5460:
1864:
892:
849:(FDA) approved erlotinib for the treatment of locally advanced or
681:
6652:
6073:
5538:
4940:
3901:
2603:
1011:
bullous, blistering, and exfoliative skin conditions (some fatal)
985:
876:
In
November 2005, the FDA approved erlotinib in combination with
865:
1828:
1145:
is battling with Roche against the Indian patent for this drug.
6565:
6229:
6118:
6043:
5748:
5743:
5167:
5162:
5116:
5112:
5108:
5104:
5100:
5096:
5092:
4744:
4283:
3961:
1712:
1074:
880:
for treatment of locally advanced, unresectable, or metastatic
798:
549:
322:
305:
301:
6597:
6593:
6589:
6585:
6581:
6577:
6573:
6569:
6284:
6183:
5858:
5798:
5612:
5335:
5331:
5327:
5323:
4814:
4678:
4597:
4593:
4492:
4488:
4484:
4480:
4389:
4385:
4236:
3483:
3209:
3043:
2992:
2472:
2265:"Roche and India's Glenmark reach truce over generic Tarceva"
1142:
920:
916:
909:
672:
529:
340:
336:
297:
1089:
Erlotinib is an epidermal growth factor receptor inhibitor (
845:(PFS) by 29%, when compared to chemotherapy alone. The U.S.
574:
41:
6068:
4674:
4670:
4666:
4662:
4658:
4654:
4589:
4585:
4581:
4577:
4573:
4476:
4472:
4464:
4460:
4456:
4452:
4448:
4444:
4440:
4381:
4377:
4373:
4369:
4365:
4361:
4357:
4309:
4305:
4301:
4267:
4232:
4213:
3598:
3384:
2882:
2608:
2590:
2580:
2540:
2408:
1067:
941:
924:
509:
770:. Specifically it is used for NSCLC with mutations in the
1474:"FDA drug approval summary: erlotinib (Tarceva) tablets"
1471:
1298:"Drug Approval Package: Tarceva (Erlotinib) NDA #021743"
1410:
1408:
970:
Partial hair loss (by strands, not typically in clumps)
822:
6668:
Pituitary adenylate cyclase-activating peptide (PACAP)
2176:
2063:
2014:
1980:
Respiration; International Review of
Thoracic Diseases
945:
though this has not been quantitatively assessed. The
27:
Medication for treatment of non-small-cell lung cancer
6714:
3800:
1381:"April 2010 - Tarceva Indication Announcement Letter"
2015:
Khurana V, Minocha M, Pal D, Mitra AK (March 2014).
1769:
1671:
1405:
1073:
Erlotinib is mainly metabolized by the liver enzyme
2127:
1066:Erlotinib is not a substrate for either of hepatic
437:
6614:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
5472:Glial cell line-derived neurotrophic factor (GDNF)
5125:Cleavage products/derivatives with unknown target:
2064:Khurana V, Minocha M, Pal D, Mitra AK (May 2014).
1974:Ren S, Li Y, Li W, Zhao Z, Jin C, Zhang D (2012).
1924:
1155:
1042:bronchiolitis obliterans with organizing pneumonia
1520:
1202:. Australian Product Information. 31 August 2022.
6738:
6648:Macrophage-stimulating protein (MSP; HLP, HGFLP)
984:, which is characterized by cough and increased
417:
4289:Heparin-binding EGF-like growth factor (HB-EGF)
3972:Heparin-binding EGF-like growth factor (HB-EGF)
1215:
1213:
1211:
1209:
392:
2057:
6797:World Health Organization essential medicines
6700:Additional growth factor receptor modulators:
3786:
2355:
1643:
1105:, which is highly expressed and occasionally
335:>98% as metabolites, of which >90% via
5054:Insulin-like growth factor-2 (somatomedin A)
4936:Insulin-like growth factor-2 (somatomedin A)
4926:Insulin-like growth factor-1 (somatomedin C)
2112:
2008:
1925:Li X, Kamenecka TM, Cameron MD (July 2010).
1763:
1706:
1665:
1572:
1330:
1206:
1190:
1188:
131:
1973:
369:-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)
3793:
3779:
2362:
2348:
1579:Asian Pacific Journal of Cancer Prevention
1262:
1260:
1258:
1256:
1254:
1252:
1250:
1248:
1163:"Erlotinib (Tarceva) Use During Pregnancy"
887:
611:
588:
477:
2145:
2089:
2040:
1991:
1950:
1882:
1805:
1795:
1738:
1689:
1590:
1546:
1489:
1448:
1221:"Tarceva- erlotinib hydrochloride tablet"
1185:
497:
6658:Migration-stimulating factor (MSF; PRG4)
891:
704:COCCOc1cc2c(cc1OCCOC)ncnc2Nc3cccc(c3)C#C
3987:Transforming growth factor alpha (TGFα)
2128:Raymond E, Faivre S, Armand JP (2000).
1647:Principles of Oncologic Pharmacotherapy
1421:intercalated TKI with chemotherapy for
1268:"Erlotinib Monograph for Professionals"
1245:
1125:It is marketed in the United States by
584:
457:
104:
14:
6739:
6561:Connective tissue growth factor (CTGF)
1644:Takimoto CH, Calvo E (15 April 2009),
1521:Kobayashi K, Hagiwara K (March 2013).
1324:
1120:
602:
235:
6624:Hepatoma-derived growth factor (HDGF)
3774:
2343:
2305:from the original on 24 December 2019
2275:from the original on 24 December 2019
2223:from the original on 6 September 2019
2070:Drug Metabolism and Drug Interactions
2021:Drug Metabolism and Drug Interactions
1905:
1625:from the original on 24 February 2022
1568:
1566:
1312:from the original on 23 December 2019
1278:from the original on 24 December 2019
1173:from the original on 12 November 2019
557:
537:
248:
122:
90:
6762:Drugs developed by Hoffmann-La Roche
871:
809:may harm the baby. It is a receptor
195:
6792:Receptor tyrosine kinase inhibitors
2140:(Suppl 1): 15–23, discussion 41–2.
1425:-mutated nonsmall cell lung cancer"
1196:"Tarceva (Erlotinib hydrochloride)"
1002:gastrointestinal tract perforations
856:that has failed at least one prior
517:
408:
24:
2243:"Erlotinib - Generic Drug Details"
1563:
1233:from the original on 6 August 2020
25:
6813:
2321:
1393:from the original on 16 July 2011
917:hepatocyte growth factor receptor
776:spread to other parts of the body
222:
154:
6724:
6643:Leukemia inhibitory factor (LIF)
2191:10.2165/00126839-200304040-00006
2147:10.2165/00003495-200060001-00002
1654:from the original on 15 May 2009
1099:epidermal growth factor receptor
997:gastrointestinal tract toxicity
815:epidermal growth factor receptor
772:epidermal growth factor receptor
642:
636:
49:
40:
5811:Negative allosteric modulators:
2287:
2257:
2235:
2205:
2170:
2121:
2106:
1967:
1931:Drug Metabolism and Disposition
1918:
1899:
1858:
1822:
1637:
1607:
1514:
1465:
1061:
930:
827:
729:Key:AAKJLRGGTJKAMG-UHFFFAOYSA-N
6129:Gossypetin (3,5,7,8,3',4'-HHF)
5320:Platelet-derived growth factor
1491:10.1634/theoncologist.10-7-461
1373:
1347:
1290:
832:
648:
630:
13:
1:
6335:Placental growth factor (PGF)
1844:10.1016/j.lungcan.2005.09.002
1691:10.1158/1078-0432.CCR-06-1570
1592:10.7314/APJCP.2012.13.10.5177
1335:. World Health Organization.
1148:
6767:Drugs developed by Genentech
6619:Glia maturation factor (GMF)
5128:Glypromate (GPE, (1-3)IGF-1)
1908:Journal of Clinical Oncology
1871:Journal of Clinical Oncology
1304:Food and Drug Administration
1093:). The drug follows Iressa (
1084:
947:Journal of Clinical Oncology
847:Food and Drug Administration
795:gastrointestinal perforation
754:, sold under the brand name
7:
1441:10.1183/23120541.00239-2022
10:
6818:
6551:Colony-stimulating factors
6543:Additional growth factors:
2865:Tyrosine kinase inhibitors
2113:Haberfeld, H, ed. (2010).
1200:Roche Products Pty Limited
1019:toxic epidermal necrolysis
854:non-small cell lung cancer
764:non-small cell lung cancer
620:Chemical and physical data
6535:
6322:
6217:
5986:
5899:SNA-120 (pegylated K252a)
5726:
5717:
5697:
5611:
5588:
5557:
5526:
5495:
5459:
5450:
5302:
5145:
5078:
5071:(against IGF-1 and IGF-2)
5040:
5033:(against IGF-1 and IGF-2)
4907:
4898:
4716:
4693:
4633:
4552:
4419:
4336:
4327:
4266:
4212:
4125:
3929:
3920:
3889:
3811:
3455:
3232:
2873:
2863:
2731:Mirvetuximab soravtansine
2623:
2504:
2464:
2399:
2386:
2333:National Cancer Institute
1539:10.1007/s11523-013-0258-9
1054:interstitial lung disease
935:
843:progression-free survival
811:tyrosine kinase inhibitor
737:
712:
692:
670:
657:
624:
619:
600:
568:
548:
528:
508:
488:
468:
448:
428:
403:
383:
351:
346:
329:
312:
291:
281:
271:
263:
212:
207:
182:
168:
142:
112:
98:
80:
72:
62:
57:
48:
39:
4735:Hepatocyte growth factor
4294:Neuregulins (heregulins)
4225:Neuregulins (heregulins)
4169:Trastuzumab duocarmazine
3882:(against angiopoietin 2)
3876:(against angiopoietin 3)
2875:Receptor tyrosine kinase
2401:Receptor tyrosine kinase
1678:Clinical Cancer Research
1331:Organization WH (2019).
1037:interstitial pneumonitis
1015:Stevens–Johnson syndrome
923:dependent activation of
4082:Depatuxizumab mafodotin
2465:Others for solid tumors
2371:Targeted cancer therapy
1884:10.1200/JCO.2004.11.057
1797:10.1073/pnas.0710370104
1740:10.1126/science.1141478
974:
888:Resistance to treatment
76:Erlotinib hydrochloride
6705:(neurotrophin mixture)
6693:Wnt signaling proteins
6374:Allosteric modulators:
6094:Norwogonin (5,7,8-THF)
4314:5 (tomoregulin, TMEFF)
4164:Trastuzumab deruxtecan
3802:Growth factor receptor
2726:Loncastuximab tesirine
2455:Trastuzumab deruxtecan
2082:10.1515/dmdi-2014-0014
2033:10.1515/dmdi-2013-0062
1943:10.1124/dmd.109.030361
1111:adenosine triphosphate
897:
6633:T-cell growth factors
4890:Telisotuzumab vedotin
4174:Trastuzumab emtansine
2801:Sacituzumab govitecan
2741:Moxetumomab pasudotox
2711:Inotuzumab ozogamicin
2614:Gemtuzumab ozogamicin
2450:Trastuzumab emtansine
2391:monoclonal antibodies
2375:antineoplastic agents
951:Lung Cancer Frontiers
895:
841:by 19%, and improved
5218:EVT-901 (SAR-127963)
4951:Mecasermin rinfabate
2656:Belantamab mafodotin
1229:. 12 December 2018.
813:, which acts on the
3509:Denileukin diftitox
3171:(ALK, ROS1, NTRK),
2776:Polatuzumab vedotin
2766:Oportuzumab monatox
2271:. 22 January 2016.
2247:DrugPatentWatch.com
1788:2007PNAS..10420932B
1782:(52): 20932–20937.
1731:2007Sci...316.1039E
1725:(5827): 1039–1043.
1361:on 22 December 2010
1169:. 1 November 2019.
1131:OSI Pharmaceuticals
1121:Society and culture
1033:Pulmonary toxicity
994:, such as eyelashes
758:among others, is a
244:(Prescription only)
231:(Prescription only)
36:
6782:Alkyne derivatives
6384:Kinase inhibitors:
6247:Kinase inhibitors:
6146:Kinase inhibitors:
5821:Kinase inhibitors:
5636:Kinase inhibitors:
5596:Kinase inhibitors:
5577:Kinase inhibitors:
5546:Kinase inhibitors:
5515:Kinase inhibitors:
5484:Kinase inhibitors:
5344:Kinase inhibitors:
4958:Kinase inhibitors:
4752:Kinase inhibitors:
4541:Kinase inhibitors:
4534:Aprutumab ixadotin
4181:Kinase inhibitors:
3994:Kinase inhibitors:
3851:Kinase inhibitors:
3195:(ROS1, TRK, ALK),
2701:Enfortumab vedotin
2299:The Economic Times
1048:pulmonary fibrosis
898:
803:corneal ulceration
372:quinazolin-4-amine
32:
6712:
6711:
6318:
6317:
6079:N-Acetylserotonin
5978:ReN-1820 (TrkAd5)
5607:
5606:
5141:
5140:
5086:Binding proteins:
4745:Dihexa (PNB-0408)
4712:
4711:
4323:
4322:
4237:6 (neuroglycan C)
3957:EGF (urogastrone)
3935:
3768:
3767:
3451:
3450:
2859:
2858:
2841:Tisotumab vedotin
2253:on 28 April 2016.
1993:10.1159/000339508
1877:(16): 3238–3247.
1684:(21): 6494–6501.
1621:(Press release).
1585:(10): 5177–5182.
1527:Targeted Oncology
1435:(4): 00239–2022.
1429:ERJ Open Research
1308:. 28 March 2005.
1133:and elsewhere by
1052:fatal asymmetric
1025:ocular disorders
1000:serious or fatal
882:pancreatic cancer
872:Pancreatic cancer
768:pancreatic cancer
749:
748:
683:Interactive image
570:CompTox Dashboard
252:
239:
226:
158:
125:
16:(Redirected from
6809:
6777:Phenyl compounds
6729:
6728:
6727:
6720:
6524:Decoy receptors:
6497:Alacizumab pegol
5975:Decoy receptors:
5724:
5723:
5629:Stem cell factor
5570:Persephin (PSPN)
5508:Neurturin (NRTN)
5457:
5456:
5294:LEVI-04 (p75-Fc)
5291:Decoy receptors:
4905:
4904:
4334:
4333:
3933:
3927:
3926:
3795:
3788:
3781:
3772:
3771:
3482:peptide against
3055:(AXL, ALK, LTK))
2871:
2870:
2681:Dinutuximab beta
2397:
2396:
2364:
2357:
2350:
2341:
2340:
2336:
2315:
2314:
2312:
2310:
2301:. 16 June 2017.
2291:
2285:
2284:
2282:
2280:
2261:
2255:
2254:
2249:. Archived from
2239:
2233:
2232:
2230:
2228:
2209:
2203:
2202:
2179:Drugs in R&D
2174:
2168:
2167:
2149:
2125:
2119:
2118:
2110:
2104:
2103:
2093:
2061:
2055:
2054:
2044:
2012:
2006:
2005:
1995:
1971:
1965:
1964:
1954:
1937:(7): 1238–1245.
1922:
1916:
1915:
1903:
1897:
1896:
1886:
1862:
1856:
1855:
1826:
1820:
1819:
1809:
1799:
1767:
1761:
1760:
1742:
1710:
1704:
1703:
1693:
1669:
1663:
1662:
1661:
1659:
1641:
1635:
1634:
1632:
1630:
1611:
1605:
1604:
1594:
1570:
1561:
1560:
1550:
1518:
1512:
1511:
1493:
1469:
1463:
1462:
1452:
1412:
1403:
1402:
1400:
1398:
1392:
1385:
1377:
1371:
1370:
1368:
1366:
1357:. Archived from
1351:
1345:
1344:
1328:
1322:
1321:
1319:
1317:
1294:
1288:
1287:
1285:
1283:
1264:
1243:
1242:
1240:
1238:
1217:
1204:
1203:
1192:
1183:
1182:
1180:
1178:
1159:
962:Loss of appetite
839:overall survival
745:
744:
685:
665:
650:
644:
638:
632:
615:
604:
593:
592:
578:
576:
561:
541:
521:
501:
481:
461:
441:
421:
411:
410:
396:
317:
250:
247:
237:
234:
224:
221:
199:
156:
153:
135:
124:
121:
108:
94:
53:
44:
37:
35:
31:
21:
6817:
6816:
6812:
6811:
6810:
6808:
6807:
6806:
6752:Astellas Pharma
6737:
6736:
6735:
6725:
6723:
6715:
6713:
6708:
6653:Midkine (NEGF2)
6531:
6314:
6213:
5982:
5920:ABT-110 (PG110)
5713:
5693:
5603:
5584:
5553:
5522:
5491:
5446:
5298:
5236:ABT-110 (PG110)
5137:
5074:
5036:
4894:
4708:
4689:
4629:
4626:(against FGF23)
4548:
4415:
4319:
4262:
4208:
4121:
3932:
3916:
3885:
3807:
3799:
3769:
3764:
3618:Pi3K inhibitors
3516:mTOR inhibitors
3447:
3228:
3199:(VEGFR, FGFR),
2855:
2619:
2500:
2460:
2382:
2368:
2327:
2324:
2319:
2318:
2308:
2306:
2293:
2292:
2288:
2278:
2276:
2263:
2262:
2258:
2241:
2240:
2236:
2226:
2224:
2219:. 15 May 2013.
2211:
2210:
2206:
2175:
2171:
2126:
2122:
2111:
2107:
2062:
2058:
2013:
2009:
1972:
1968:
1923:
1919:
1904:
1900:
1863:
1859:
1827:
1823:
1768:
1764:
1711:
1707:
1670:
1666:
1657:
1655:
1642:
1638:
1628:
1626:
1613:
1612:
1608:
1571:
1564:
1519:
1515:
1470:
1466:
1413:
1406:
1396:
1394:
1390:
1383:
1379:
1378:
1374:
1364:
1362:
1353:
1352:
1348:
1329:
1325:
1315:
1313:
1296:
1295:
1291:
1281:
1279:
1266:
1265:
1246:
1236:
1234:
1219:
1218:
1207:
1194:
1193:
1186:
1176:
1174:
1161:
1160:
1156:
1151:
1123:
1103:tyrosine kinase
1087:
1064:
1028:corneal lesions
977:
938:
933:
919:, which drives
890:
874:
835:
830:
787:kidney problems
740:
738:
733:
730:
725:
720:
719:
708:
705:
700:
699:
688:
663:
653:
647:
641:
635:
596:
572:
564:
544:
524:
504:
484:
464:
444:
424:
407:
399:
379:
376:
375:
359:
358:
315:
283:Protein binding
273:Bioavailability
265:Pharmacokinetic
259:
203:
171:
164:
145:
138:
28:
23:
22:
15:
12:
11:
5:
6815:
6805:
6804:
6799:
6794:
6789:
6784:
6779:
6774:
6769:
6764:
6759:
6754:
6749:
6734:
6733:
6710:
6709:
6707:
6706:
6696:
6695:
6690:
6683:Thrombopoietin
6680:
6675:
6670:
6665:
6660:
6655:
6650:
6645:
6640:
6626:
6621:
6616:
6611:
6604:Erythropoietin
6601:
6563:
6558:
6548:
6546:Adrenomedullin
6539:
6537:
6533:
6532:
6530:
6529:
6520:
6519:
6514:
6509:
6504:
6499:
6490:
6489:
6484:
6479:
6474:
6469:
6464:
6459:
6454:
6449:
6444:
6439:
6434:
6429:
6424:
6419:
6414:
6409:
6404:
6399:
6394:
6389:
6380:
6379:
6370:
6369:
6347:
6342:
6337:
6328:
6326:
6320:
6319:
6316:
6315:
6313:
6312:
6307:
6302:
6297:
6292:
6287:
6282:
6277:
6272:
6267:
6262:
6257:
6252:
6243:
6242:
6237:
6232:
6223:
6221:
6215:
6214:
6212:
6211:
6206:
6201:
6196:
6191:
6186:
6181:
6176:
6171:
6166:
6161:
6156:
6151:
6142:
6141:
6132:
6131:
6126:
6121:
6112:
6111:
6106:
6101:
6096:
6091:
6086:
6081:
6076:
6071:
6066:
6061:
6056:
6051:
6046:
6041:
6036:
6031:
6026:
6021:
6016:
6011:
6009:4'-DMA-7,8-DHF
6006:
6001:
5992:
5990:
5984:
5983:
5981:
5980:
5971:
5970:
5958:
5957:
5952:
5947:
5942:
5937:
5932:
5927:
5922:
5903:
5902:
5896:
5891:
5886:
5881:
5876:
5871:
5866:
5861:
5856:
5851:
5846:
5841:
5836:
5831:
5826:
5817:
5816:
5807:
5806:
5801:
5796:
5791:
5782:
5781:
5776:
5771:
5769:Gambogic amide
5766:
5761:
5756:
5751:
5746:
5741:
5732:
5730:
5721:
5715:
5714:
5712:
5711:
5703:
5701:
5695:
5694:
5692:
5691:
5686:
5681:
5676:
5671:
5666:
5661:
5656:
5651:
5646:
5641:
5632:
5631:
5626:
5617:
5615:
5609:
5608:
5605:
5604:
5602:
5601:
5592:
5590:
5586:
5585:
5583:
5582:
5573:
5572:
5563:
5561:
5555:
5554:
5552:
5551:
5542:
5541:
5539:Artemin (ARTN)
5532:
5530:
5524:
5523:
5521:
5520:
5511:
5510:
5501:
5499:
5493:
5492:
5490:
5489:
5480:
5479:
5474:
5465:
5463:
5454:
5448:
5447:
5445:
5444:
5439:
5434:
5425:
5424:
5419:
5414:
5409:
5404:
5399:
5394:
5389:
5384:
5379:
5374:
5369:
5364:
5359:
5354:
5349:
5340:
5339:
5317:
5308:
5306:
5300:
5299:
5297:
5296:
5287:
5286:
5274:
5273:
5268:
5263:
5258:
5253:
5248:
5243:
5238:
5226:
5225:
5220:
5215:
5210:
5201:
5200:
5195:
5190:
5185:
5180:
5175:
5170:
5165:
5160:
5151:
5149:
5143:
5142:
5139:
5138:
5136:
5135:
5130:
5121:
5120:
5082:
5080:
5076:
5075:
5073:
5072:
5066:
5057:
5056:
5046:
5044:
5038:
5037:
5035:
5034:
5028:
5023:
5018:
5013:
5008:
5003:
4998:
4993:
4984:
4983:
4978:
4973:
4968:
4963:
4954:
4953:
4948:
4943:
4938:
4933:
4928:
4923:
4913:
4911:
4902:
4896:
4895:
4893:
4892:
4887:
4882:
4877:
4872:
4867:
4862:
4853:
4852:
4847:
4842:
4837:
4832:
4827:
4822:
4817:
4812:
4807:
4802:
4797:
4792:
4787:
4782:
4777:
4772:
4767:
4762:
4757:
4748:
4747:
4738:
4737:
4732:
4722:
4720:
4714:
4713:
4710:
4709:
4707:
4706:
4697:
4695:
4691:
4690:
4688:
4687:
4682:
4648:
4639:
4637:
4631:
4630:
4628:
4627:
4617:
4616:
4611:
4606:
4601:
4567:
4558:
4556:
4550:
4549:
4547:
4546:
4537:
4536:
4531:
4522:
4521:
4516:
4511:
4506:
4501:
4496:
4434:
4425:
4423:
4417:
4416:
4414:
4413:
4408:
4403:
4398:
4393:
4351:
4342:
4340:
4331:
4325:
4324:
4321:
4320:
4318:
4317:
4291:
4286:
4281:
4272:
4270:
4264:
4263:
4261:
4260:
4255:
4250:
4241:
4240:
4218:
4216:
4210:
4209:
4207:
4206:
4201:
4196:
4191:
4186:
4177:
4176:
4171:
4166:
4161:
4156:
4151:
4142:
4141:
4131:
4129:
4123:
4122:
4120:
4119:
4114:
4109:
4104:
4099:
4094:
4089:
4084:
4079:
4074:
4065:
4064:
4059:
4054:
4049:
4044:
4039:
4034:
4029:
4024:
4019:
4014:
4009:
4004:
3999:
3990:
3989:
3984:
3979:
3974:
3969:
3964:
3959:
3954:
3949:
3939:
3937:
3924:
3918:
3917:
3915:
3914:
3909:
3904:
3895:
3893:
3887:
3886:
3884:
3883:
3877:
3867:
3866:
3861:
3856:
3847:
3846:
3844:Angiopoietin 3
3841:
3839:Angiopoietin 2
3832:
3831:
3829:Angiopoietin 4
3826:
3824:Angiopoietin 1
3817:
3815:
3809:
3808:
3798:
3797:
3790:
3783:
3775:
3766:
3765:
3763:
3762:
3757:
3752:
3747:
3742:
3737:
3732:
3727:
3722:
3717:
3712:
3707:
3702:
3697:
3692:
3687:
3682:
3677:
3672:
3667:
3662:
3657:
3652:
3647:
3646:
3645:
3640:
3635:
3630:
3625:
3615:
3614:
3613:
3608:
3595:
3594:
3593:
3588:
3583:
3578:
3573:
3565:CDK inhibitors
3561:
3560:
3559:
3554:
3549:
3536:
3535:
3534:
3529:
3524:
3512:
3496:
3476:
3464:fusion protein
3459:
3457:
3453:
3452:
3449:
3448:
3446:
3445:
3444:
3443:
3438:
3433:
3428:
3423:
3410:
3409:
3408:
3407:
3402:
3397:
3380:
3379:
3378:
3377:
3372:
3367:
3362:
3349:
3348:
3347:
3346:
3341:
3336:
3331:
3326:
3321:
3316:
3303:
3302:
3296:
3284:
3283:
3282:
3281:
3276:
3271:
3266:
3261:
3256:
3251:
3238:
3236:
3230:
3229:
3227:
3226:
3205:
3204:
3203:(VEGFR, EGFR).
3159:
3158:
3157:
3156:
3151:
3146:
3133:
3132:
3131:
3130:
3125:
3120:
3115:
3110:
3105:
3100:
3095:
3090:
3085:
3080:
3075:
3070:
3057:
3056:
3040:
3034:
3029:
3024:
3019:
3014:
3009:
3004:
2984:
2983:
2982:
2981:
2976:
2971:
2961:HER1/EGFR and
2957:
2956:
2950:
2945:
2940:
2935:
2930:
2925:
2920:
2915:
2910:
2905:
2900:
2895:
2879:
2877:
2868:
2861:
2860:
2857:
2856:
2854:
2853:
2848:
2843:
2838:
2833:
2828:
2823:
2818:
2813:
2808:
2803:
2798:
2793:
2788:
2783:
2778:
2773:
2768:
2763:
2758:
2753:
2748:
2743:
2738:
2733:
2728:
2723:
2718:
2713:
2708:
2703:
2698:
2693:
2688:
2683:
2678:
2673:
2668:
2663:
2658:
2653:
2648:
2643:
2640:+hyaluronidase
2633:
2627:
2625:
2621:
2620:
2618:
2617:
2600:
2599:
2573:
2568:
2563:
2558:
2553:
2548:
2514:
2512:
2502:
2501:
2499:
2498:
2486:
2480:
2468:
2466:
2462:
2461:
2459:
2458:
2452:
2447:
2444:+hyaluronidase
2427:
2421:
2405:
2403:
2394:
2384:
2383:
2367:
2366:
2359:
2352:
2344:
2338:
2337:
2323:
2322:External links
2320:
2317:
2316:
2286:
2256:
2234:
2204:
2185:(4): 243–248.
2169:
2120:
2105:
2076:(4): 249–259.
2056:
2027:(3): 179–190.
2007:
1986:(5): 431–435.
1966:
1917:
1898:
1857:
1821:
1762:
1705:
1664:
1636:
1606:
1562:
1513:
1484:(7): 461–466.
1478:The Oncologist
1464:
1404:
1372:
1346:
1323:
1289:
1244:
1205:
1184:
1153:
1152:
1150:
1147:
1122:
1119:
1091:EGFR inhibitor
1086:
1083:
1079:St John's wort
1063:
1060:
1059:
1058:
1057:
1056:
1050:
1045:
1039:
1031:
1030:
1029:
1023:
1022:
1021:
1012:
1008:skin toxicity
1006:
1005:
1004:
995:
989:
976:
973:
972:
971:
968:
963:
960:
955:
937:
934:
932:
929:
889:
886:
873:
870:
834:
831:
829:
826:
778:. It is taken
762:used to treat
747:
746:
735:
734:
732:
731:
728:
726:
723:
715:
714:
713:
710:
709:
707:
706:
703:
695:
694:
693:
690:
689:
687:
686:
678:
676:
668:
667:
661:
655:
654:
651:
645:
639:
633:
628:
622:
621:
617:
616:
606:
598:
597:
595:
594:
581:
579:
566:
565:
563:
562:
554:
552:
546:
545:
543:
542:
534:
532:
526:
525:
523:
522:
514:
512:
506:
505:
503:
502:
494:
492:
486:
485:
483:
482:
474:
472:
466:
465:
463:
462:
454:
452:
446:
445:
443:
442:
434:
432:
426:
425:
423:
422:
414:
412:
401:
400:
398:
397:
389:
387:
381:
380:
378:
377:
374:
373:
370:
363:
362:
354:
353:
352:
349:
348:
344:
343:
333:
327:
326:
319:
310:
309:
295:
289:
288:
285:
279:
278:
275:
269:
268:
261:
260:
258:
257:
245:
232:
218:
216:
210:
209:
205:
204:
202:
201:
188:
186:
180:
179:
174:
172:administration
166:
165:
163:
162:
160:
150:
148:
140:
139:
137:
136:
118:
116:
110:
109:
102:
96:
95:
88:
78:
77:
74:
70:
69:
66:
60:
59:
55:
54:
46:
45:
26:
9:
6:
4:
3:
2:
6814:
6803:
6800:
6798:
6795:
6793:
6790:
6788:
6785:
6783:
6780:
6778:
6775:
6773:
6772:Phenol ethers
6770:
6768:
6765:
6763:
6760:
6758:
6755:
6753:
6750:
6748:
6745:
6744:
6742:
6732:
6722:
6721:
6718:
6704:
6701:
6698:
6697:
6694:
6691:
6688:
6684:
6681:
6679:
6676:
6674:
6671:
6669:
6666:
6664:
6661:
6659:
6656:
6654:
6651:
6649:
6646:
6644:
6641:
6638:
6634:
6630:
6627:
6625:
6622:
6620:
6617:
6615:
6612:
6609:
6605:
6602:
6599:
6595:
6591:
6587:
6583:
6579:
6575:
6571:
6567:
6564:
6562:
6559:
6556:
6552:
6549:
6547:
6544:
6541:
6540:
6538:
6534:
6528:
6525:
6522:
6521:
6518:
6515:
6513:
6510:
6508:
6505:
6503:
6500:
6498:
6495:
6492:
6491:
6488:
6485:
6483:
6480:
6478:
6475:
6473:
6470:
6468:
6465:
6463:
6460:
6458:
6455:
6453:
6450:
6448:
6445:
6443:
6440:
6438:
6435:
6433:
6430:
6428:
6425:
6423:
6420:
6418:
6415:
6413:
6410:
6408:
6405:
6403:
6400:
6398:
6395:
6393:
6390:
6388:
6385:
6382:
6381:
6378:
6377:Cyclotraxin B
6375:
6372:
6371:
6367:
6363:
6359:
6355:
6351:
6348:
6346:
6343:
6341:
6338:
6336:
6333:
6330:
6329:
6327:
6325:
6321:
6311:
6308:
6306:
6303:
6301:
6298:
6296:
6293:
6291:
6290:Larotrectinib
6288:
6286:
6283:
6281:
6278:
6276:
6273:
6271:
6268:
6266:
6263:
6261:
6258:
6256:
6253:
6251:
6248:
6245:
6244:
6241:
6238:
6236:
6233:
6231:
6228:
6225:
6224:
6222:
6220:
6216:
6210:
6207:
6205:
6202:
6200:
6197:
6195:
6192:
6190:
6189:Larotrectinib
6187:
6185:
6182:
6180:
6177:
6175:
6172:
6170:
6167:
6165:
6162:
6160:
6157:
6155:
6152:
6150:
6147:
6144:
6143:
6140:
6137:
6134:
6133:
6130:
6127:
6125:
6124:Cyclotraxin B
6122:
6120:
6117:
6114:
6113:
6110:
6107:
6105:
6102:
6100:
6097:
6095:
6092:
6090:
6087:
6085:
6082:
6080:
6077:
6075:
6072:
6070:
6067:
6065:
6062:
6060:
6057:
6055:
6052:
6050:
6047:
6045:
6042:
6040:
6037:
6035:
6034:Amitriptyline
6032:
6030:
6027:
6025:
6022:
6020:
6017:
6015:
6012:
6010:
6007:
6005:
6002:
6000:
5997:
5994:
5993:
5991:
5989:
5985:
5979:
5976:
5973:
5972:
5969:
5966:
5963:
5960:
5959:
5956:
5953:
5951:
5948:
5946:
5943:
5941:
5938:
5936:
5933:
5931:
5928:
5926:
5923:
5921:
5918:
5914:
5911:
5910:Against TrkA:
5908:
5905:
5904:
5900:
5897:
5895:
5892:
5890:
5887:
5885:
5882:
5880:
5877:
5875:
5872:
5870:
5867:
5865:
5864:Larotrectinib
5862:
5860:
5857:
5855:
5852:
5850:
5847:
5845:
5842:
5840:
5837:
5835:
5832:
5830:
5827:
5825:
5822:
5819:
5818:
5815:
5812:
5809:
5808:
5805:
5802:
5800:
5797:
5795:
5794:Dexamethasone
5792:
5790:
5787:
5784:
5783:
5780:
5777:
5775:
5772:
5770:
5767:
5765:
5762:
5760:
5757:
5755:
5752:
5750:
5747:
5745:
5742:
5740:
5739:Amitriptyline
5737:
5734:
5733:
5731:
5729:
5725:
5722:
5720:
5716:
5709:
5705:
5704:
5702:
5700:
5696:
5690:
5687:
5685:
5682:
5680:
5677:
5675:
5672:
5670:
5667:
5665:
5662:
5660:
5657:
5655:
5652:
5650:
5647:
5645:
5642:
5640:
5637:
5634:
5633:
5630:
5627:
5625:
5622:
5619:
5618:
5616:
5614:
5610:
5600:
5597:
5594:
5593:
5591:
5587:
5581:
5578:
5575:
5574:
5571:
5568:
5565:
5564:
5562:
5560:
5556:
5550:
5547:
5544:
5543:
5540:
5537:
5534:
5533:
5531:
5529:
5525:
5519:
5516:
5513:
5512:
5509:
5506:
5503:
5502:
5500:
5498:
5494:
5488:
5485:
5482:
5481:
5478:
5475:
5473:
5470:
5467:
5466:
5464:
5462:
5458:
5455:
5453:
5449:
5443:
5440:
5438:
5435:
5433:
5430:
5427:
5426:
5423:
5420:
5418:
5415:
5413:
5410:
5408:
5405:
5403:
5400:
5398:
5395:
5393:
5390:
5388:
5385:
5383:
5380:
5378:
5375:
5373:
5370:
5368:
5365:
5363:
5360:
5358:
5355:
5353:
5350:
5348:
5345:
5342:
5341:
5337:
5333:
5329:
5325:
5321:
5318:
5316:
5313:
5310:
5309:
5307:
5305:
5301:
5295:
5292:
5289:
5288:
5285:
5282:
5279:
5276:
5275:
5272:
5269:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5247:
5244:
5242:
5239:
5237:
5234:
5231:
5228:
5227:
5224:
5221:
5219:
5216:
5214:
5213:Dexamethasone
5211:
5209:
5206:
5203:
5202:
5199:
5196:
5194:
5191:
5189:
5186:
5184:
5181:
5179:
5176:
5174:
5171:
5169:
5166:
5164:
5161:
5159:
5156:
5153:
5152:
5150:
5148:
5144:
5134:
5131:
5129:
5126:
5123:
5122:
5118:
5114:
5110:
5106:
5102:
5098:
5094:
5090:
5087:
5084:
5083:
5081:
5077:
5070:
5067:
5065:
5062:
5059:
5058:
5055:
5051:
5048:
5047:
5045:
5043:
5039:
5032:
5029:
5027:
5024:
5022:
5019:
5017:
5014:
5012:
5009:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4986:
4985:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4956:
4955:
4952:
4949:
4947:
4944:
4942:
4939:
4937:
4934:
4932:
4929:
4927:
4924:
4922:
4921:des(1-3)IGF-1
4918:
4915:
4914:
4912:
4910:
4906:
4903:
4901:
4897:
4891:
4888:
4886:
4885:Telisotuzumab
4883:
4881:
4878:
4876:
4873:
4871:
4868:
4866:
4863:
4861:
4858:
4855:
4854:
4851:
4848:
4846:
4843:
4841:
4838:
4836:
4833:
4831:
4828:
4826:
4823:
4821:
4818:
4816:
4813:
4811:
4808:
4806:
4803:
4801:
4798:
4796:
4793:
4791:
4788:
4786:
4783:
4781:
4778:
4776:
4773:
4771:
4768:
4766:
4763:
4761:
4758:
4756:
4753:
4750:
4749:
4746:
4743:
4742:Potentiators:
4740:
4739:
4736:
4733:
4731:
4727:
4724:
4723:
4721:
4719:
4715:
4705:
4702:
4699:
4698:
4696:
4692:
4686:
4683:
4680:
4676:
4672:
4668:
4664:
4660:
4656:
4652:
4649:
4647:
4644:
4641:
4640:
4638:
4636:
4632:
4625:
4622:
4619:
4618:
4615:
4612:
4610:
4607:
4605:
4604:Selpercatinib
4602:
4599:
4595:
4591:
4587:
4583:
4579:
4575:
4571:
4568:
4566:
4563:
4560:
4559:
4557:
4555:
4551:
4545:
4542:
4539:
4538:
4535:
4532:
4530:
4527:
4524:
4523:
4520:
4517:
4515:
4512:
4510:
4509:Selpercatinib
4507:
4505:
4502:
4500:
4497:
4494:
4490:
4486:
4482:
4478:
4474:
4470:
4466:
4462:
4458:
4454:
4450:
4446:
4442:
4438:
4435:
4433:
4430:
4427:
4426:
4424:
4422:
4418:
4412:
4409:
4407:
4404:
4402:
4401:Selpercatinib
4399:
4397:
4394:
4391:
4387:
4383:
4379:
4375:
4371:
4367:
4363:
4359:
4355:
4352:
4350:
4347:
4344:
4343:
4341:
4339:
4335:
4332:
4330:
4326:
4315:
4311:
4307:
4303:
4299:
4295:
4292:
4290:
4287:
4285:
4282:
4280:
4277:
4274:
4273:
4271:
4269:
4265:
4259:
4256:
4254:
4251:
4249:
4246:
4243:
4242:
4238:
4234:
4230:
4226:
4223:
4220:
4219:
4217:
4215:
4211:
4205:
4202:
4200:
4197:
4195:
4192:
4190:
4187:
4185:
4182:
4179:
4178:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4147:
4144:
4143:
4140:
4136:
4133:
4132:
4130:
4128:
4124:
4118:
4115:
4113:
4110:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4088:
4085:
4083:
4080:
4078:
4077:Depatuxizumab
4075:
4073:
4070:
4067:
4066:
4063:
4060:
4058:
4055:
4053:
4050:
4048:
4045:
4043:
4040:
4038:
4035:
4033:
4030:
4028:
4025:
4023:
4020:
4018:
4015:
4013:
4010:
4008:
4005:
4003:
4000:
3998:
3995:
3992:
3991:
3988:
3985:
3983:
3980:
3978:
3975:
3973:
3970:
3968:
3965:
3963:
3960:
3958:
3955:
3953:
3950:
3948:
3944:
3941:
3940:
3938:
3936:
3928:
3925:
3923:
3919:
3913:
3910:
3908:
3905:
3903:
3900:
3897:
3896:
3894:
3892:
3888:
3881:
3878:
3875:
3872:
3869:
3868:
3865:
3862:
3860:
3857:
3855:
3852:
3849:
3848:
3845:
3842:
3840:
3837:
3834:
3833:
3830:
3827:
3825:
3822:
3819:
3818:
3816:
3814:
3810:
3806:
3803:
3796:
3791:
3789:
3784:
3782:
3777:
3776:
3773:
3761:
3758:
3756:
3753:
3751:
3748:
3746:
3743:
3741:
3738:
3736:
3733:
3731:
3728:
3726:
3723:
3721:
3718:
3716:
3713:
3711:
3708:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
3688:
3686:
3683:
3681:
3678:
3676:
3675:Larotrectinib
3673:
3671:
3668:
3666:
3663:
3661:
3658:
3656:
3653:
3651:
3648:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3620:
3619:
3616:
3612:
3609:
3607:
3604:
3603:
3602:
3600:
3596:
3592:
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3572:
3569:
3568:
3567:
3566:
3562:
3558:
3555:
3553:
3550:
3548:
3545:
3544:
3543:
3541:
3537:
3533:
3530:
3528:
3527:Ridaforolimus
3525:
3523:
3520:
3519:
3518:
3517:
3513:
3510:
3506:
3505:
3501:
3497:
3494:
3490:
3489:
3485:
3481:
3477:
3474:
3470:
3469:
3465:
3461:
3460:
3458:
3454:
3442:
3439:
3437:
3436:Pirtobrutinib
3434:
3432:
3431:Orelabrutinib
3429:
3427:
3424:
3422:
3421:Acalabrutinib
3419:
3418:
3417:
3416:
3412:
3411:
3406:
3403:
3401:
3398:
3396:
3393:
3392:
3391:
3390:
3386:
3382:
3381:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3357:
3356:
3355:
3351:
3350:
3345:
3342:
3340:
3337:
3335:
3332:
3330:
3327:
3325:
3322:
3320:
3317:
3315:
3312:
3311:
3310:
3309:
3305:
3304:
3300:
3297:
3295:
3291:
3290:
3286:
3285:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3252:
3250:
3247:
3246:
3245:
3244:
3240:
3239:
3237:
3235:
3231:
3224:
3220:
3216:
3213:
3211:
3207:
3206:
3202:
3198:
3197:Selpercatinib
3194:
3193:Repotrectinib
3190:
3186:
3182:
3181:Larotrectinib
3178:
3174:
3170:
3167:
3165:
3161:
3160:
3155:
3152:
3150:
3147:
3145:
3142:
3141:
3140:
3139:
3135:
3134:
3129:
3126:
3124:
3121:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3065:
3064:
3063:
3059:
3058:
3054:
3050:
3046:
3045:
3041:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
2999:
2998:
2994:
2989:
2988:RTK class III
2986:
2985:
2980:
2977:
2975:
2972:
2970:
2967:
2966:
2965:
2964:
2959:
2958:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2906:
2904:
2901:
2899:
2896:
2894:
2890:
2889:
2884:
2881:
2880:
2878:
2876:
2872:
2869:
2866:
2862:
2852:
2849:
2847:
2844:
2842:
2839:
2837:
2834:
2832:
2829:
2827:
2824:
2822:
2819:
2817:
2814:
2812:
2809:
2807:
2804:
2802:
2799:
2797:
2794:
2792:
2789:
2787:
2784:
2782:
2779:
2777:
2774:
2772:
2771:Pembrolizumab
2769:
2767:
2764:
2762:
2759:
2757:
2754:
2752:
2749:
2747:
2744:
2742:
2739:
2737:
2736:Mogamulizumab
2734:
2732:
2729:
2727:
2724:
2722:
2719:
2717:
2714:
2712:
2709:
2707:
2704:
2702:
2699:
2697:
2694:
2692:
2689:
2687:
2684:
2682:
2679:
2677:
2674:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2641:
2637:
2634:
2632:
2629:
2628:
2626:
2622:
2615:
2611:
2610:
2605:
2602:
2601:
2597:
2593:
2592:
2587:
2583:
2582:
2577:
2574:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2556:Mosunetuzumab
2554:
2552:
2549:
2547:
2543:
2542:
2537:
2536:Mosunetuzumab
2533:
2529:
2525:
2524:
2519:
2516:
2515:
2513:
2511:
2507:
2503:
2496:
2492:
2491:
2487:
2484:
2481:
2479:
2475:
2474:
2470:
2469:
2467:
2463:
2456:
2453:
2451:
2448:
2445:
2441:
2437:
2433:
2432:
2428:
2425:
2422:
2420:
2416:
2415:
2410:
2407:
2406:
2404:
2402:
2398:
2395:
2392:
2389:
2385:
2380:
2376:
2372:
2365:
2360:
2358:
2353:
2351:
2346:
2345:
2342:
2334:
2330:
2326:
2325:
2304:
2300:
2296:
2290:
2274:
2270:
2266:
2260:
2252:
2248:
2244:
2238:
2222:
2218:
2214:
2208:
2200:
2196:
2192:
2188:
2184:
2180:
2173:
2165:
2161:
2157:
2153:
2148:
2143:
2139:
2135:
2131:
2124:
2116:
2115:Austria-Codex
2109:
2101:
2097:
2092:
2087:
2083:
2079:
2075:
2071:
2067:
2060:
2052:
2048:
2043:
2038:
2034:
2030:
2026:
2022:
2018:
2011:
2003:
1999:
1994:
1989:
1985:
1981:
1977:
1970:
1962:
1958:
1953:
1948:
1944:
1940:
1936:
1932:
1928:
1921:
1913:
1909:
1902:
1894:
1890:
1885:
1880:
1876:
1872:
1868:
1861:
1853:
1849:
1845:
1841:
1837:
1833:
1825:
1817:
1813:
1808:
1803:
1798:
1793:
1789:
1785:
1781:
1777:
1773:
1766:
1758:
1754:
1750:
1746:
1741:
1736:
1732:
1728:
1724:
1720:
1716:
1709:
1701:
1697:
1692:
1687:
1683:
1679:
1675:
1668:
1653:
1649:
1648:
1640:
1624:
1620:
1616:
1610:
1602:
1598:
1593:
1588:
1584:
1580:
1576:
1569:
1567:
1558:
1554:
1549:
1544:
1540:
1536:
1532:
1528:
1524:
1517:
1509:
1505:
1501:
1497:
1492:
1487:
1483:
1479:
1475:
1468:
1460:
1456:
1451:
1446:
1442:
1438:
1434:
1430:
1426:
1424:
1420:
1411:
1409:
1389:
1382:
1376:
1360:
1356:
1350:
1342:
1338:
1334:
1327:
1311:
1307:
1305:
1299:
1293:
1277:
1273:
1269:
1263:
1261:
1259:
1257:
1255:
1253:
1251:
1249:
1232:
1228:
1227:
1222:
1216:
1214:
1212:
1210:
1201:
1197:
1191:
1189:
1172:
1168:
1164:
1158:
1154:
1146:
1144:
1138:
1136:
1132:
1128:
1118:
1116:
1112:
1108:
1104:
1100:
1096:
1092:
1082:
1080:
1076:
1071:
1069:
1055:
1051:
1049:
1046:
1043:
1040:
1038:
1035:
1034:
1032:
1027:
1026:
1024:
1020:
1016:
1013:
1010:
1009:
1007:
1003:
999:
998:
996:
993:
992:ingrown hairs
990:
987:
983:
980:interstitial
979:
978:
969:
967:
964:
961:
959:
956:
952:
948:
943:
940:
939:
928:
926:
922:
918:
913:
911:
907:
903:
894:
885:
883:
879:
869:
867:
861:
859:
855:
852:
848:
844:
840:
825:
823:
818:
816:
812:
808:
804:
800:
796:
792:
791:liver failure
788:
783:
781:
777:
773:
769:
765:
761:
757:
753:
743:
736:
727:
722:
721:
718:
711:
702:
701:
698:
691:
684:
680:
679:
677:
674:
669:
662:
660:
656:
629:
627:
623:
618:
614:
610:
607:
605:
603:ECHA InfoCard
599:
591:
587:
586:DTXSID8046454
583:
582:
580:
571:
567:
560:
556:
555:
553:
551:
547:
540:
536:
535:
533:
531:
527:
520:
516:
515:
513:
511:
507:
500:
496:
495:
493:
491:
487:
480:
476:
475:
473:
471:
467:
460:
456:
455:
453:
451:
447:
440:
436:
435:
433:
431:
427:
420:
416:
415:
413:
406:
402:
395:
391:
390:
388:
386:
382:
371:
368:
365:
364:
361:
360:
357:
350:
345:
342:
338:
334:
332:
328:
324:
320:
318:
311:
307:
303:
299:
296:
294:
290:
286:
284:
280:
276:
274:
270:
266:
262:
256:
246:
243:
233:
230:
220:
219:
217:
215:
211:
206:
198:
193:
190:
189:
187:
185:
181:
178:
175:
173:
167:
161:
152:
151:
149:
147:
141:
134:
129:
120:
119:
117:
115:
111:
107:
103:
101:
97:
93:
89:
87:
83:
79:
75:
71:
67:
65:
61:
58:Clinical data
56:
52:
47:
43:
38:
30:
19:
6802:Orphan drugs
6787:Quinazolines
6703:Cerebrolysin
6699:
6673:Pleiotrophin
6629:Interleukins
6542:
6523:
6493:
6412:Fruquintinib
6402:Cabozantinib
6383:
6373:
6331:
6295:Lestaurtinib
6246:
6226:
6194:Lestaurtinib
6145:
6135:
6116:Antagonists:
6115:
6049:Deoxygedunin
6004:3,7,8,2'-THF
5995:
5974:
5965:Against NGF:
5964:
5961:
5917:Against NGF:
5916:
5909:
5906:
5869:Lestaurtinib
5820:
5810:
5804:Testosterone
5786:Antagonists:
5785:
5735:
5635:
5620:
5595:
5576:
5566:
5545:
5535:
5514:
5504:
5483:
5468:
5428:
5343:
5311:
5290:
5281:Against NGF:
5280:
5277:
5233:Against NGF:
5232:
5229:
5223:Testosterone
5205:Antagonists:
5204:
5154:
5124:
5085:
5060:
5049:
5026:Teprotumumab
4987:
4957:
4916:
4865:Ficlatuzumab
4860:Emibetuzumab
4856:
4810:JNJ-38877605
4780:Cabozantinib
4751:
4741:
4730:Fosgonimeton
4725:
4700:
4642:
4620:
4561:
4544:Infigratinib
4540:
4525:
4428:
4345:
4279:Betacellulin
4275:
4258:Seribantumab
4244:
4221:
4180:
4145:
4139:Unknown/none
4138:
4134:
4068:
4021:
3993:
3952:Betacellulin
3947:Amphiregulin
3942:
3934:(ErbB1/HER1)
3898:
3870:
3850:
3836:Antagonists:
3835:
3820:
3813:Angiopoietin
3715:Pexidartinib
3700:Odronextamab
3670:Gilteritinib
3650:Cabozantinib
3597:
3563:
3538:
3532:Temsirolimus
3514:
3498:
3480:proapoptotic
3478:
3462:
3441:Zanubrutinib
3413:
3383:
3352:
3329:Lestaurtinib
3308:Janus kinase
3306:
3287:
3241:
3234:Non-receptor
3215:Cabozantinib
3208:
3177:Infigratinib
3162:
3136:
3078:Fruquintinib
3060:
3053:Gilteritinib
3049:Lestaurtinib
3042:
2991:
2960:
2933:Mobocertinib
2912:
2898:Aumolertinib
2886:
2851:Tremelimumab
2836:Tislelizumab
2791:Retifanlimab
2666:Blinatumomab
2636:Atezolizumab
2607:
2589:
2579:
2561:Obinutuzumab
2539:
2521:
2488:
2471:
2429:
2412:
2332:
2307:. Retrieved
2298:
2289:
2277:. Retrieved
2268:
2259:
2251:the original
2246:
2237:
2225:. Retrieved
2216:
2207:
2182:
2178:
2172:
2137:
2133:
2123:
2114:
2108:
2073:
2069:
2059:
2024:
2020:
2010:
1983:
1979:
1969:
1934:
1930:
1920:
1911:
1907:
1901:
1874:
1870:
1860:
1838:(1): 89–96.
1835:
1831:
1824:
1779:
1775:
1765:
1722:
1718:
1708:
1681:
1677:
1667:
1656:, retrieved
1646:
1639:
1627:. Retrieved
1618:
1609:
1582:
1578:
1533:(1): 27–33.
1530:
1526:
1516:
1481:
1477:
1467:
1432:
1428:
1422:
1418:
1395:. Retrieved
1375:
1363:. Retrieved
1359:the original
1349:
1341:10665/325771
1332:
1326:
1314:. Retrieved
1301:
1292:
1280:. Retrieved
1271:
1235:. Retrieved
1224:
1199:
1175:. Retrieved
1166:
1157:
1139:
1124:
1088:
1072:
1065:
1062:Interactions
950:
946:
931:Side effects
914:
899:
875:
862:
858:chemotherapy
836:
828:Medical uses
819:
784:
766:(NSCLC) and
755:
751:
750:
739:
539:CHEBI:114785
366:
314:Elimination
214:Legal status
208:Legal status
114:License data
29:
6663:Oncomodulin
6527:Aflibercept
6517:Ranibizumab
6512:Ramucirumab
6502:Bevacizumab
6494:Antibodies:
6452:Regorafenib
6392:Altiratinib
6305:ONO-5390556
6275:Entrectinib
6250:Altiratinib
6204:ONO-5390556
6174:Entrectinib
6149:Altiratinib
5935:Frunevetmab
5907:Antibodies:
5884:ONO-5390556
5849:Entrectinib
5824:Altiratinib
5779:Tavilermide
5674:Quizartinib
5613:SCF (c-Kit)
5437:Ramucirumab
5429:Antibodies:
5402:Quizartinib
5352:Avapritinib
5315:Becaplermin
5251:Frunevetmab
5230:Antibodies:
5133:Trofinetide
5064:Dusigitumab
5061:Antibodies:
5016:Robatumumab
5006:Figitumumab
5001:Dalotuzumab
4996:Cixutumumab
4988:Antibodies:
4880:Rilotumumab
4875:Onartuzumab
4870:Flanvotumab
4857:Antibodies:
4825:PF-04217903
4755:Altiratinib
4718:HGF (c-Met)
4621:Antibodies:
4526:Antibodies:
4248:Duligotumab
4245:Antibodies:
4159:Trastuzumab
4149:Ertumaxomab
4146:Antibodies:
4117:Zalutumumab
4112:Panitumumab
4107:Nimotuzumab
4102:Necitumumab
4092:Imgatuzumab
4069:Antibodies:
4052:Osimertinib
4017:Dacomitinib
3912:Dapiclermin
3871:Antibodies:
3854:Altiratinib
3745:Tebentafusp
3725:Regorafenib
3720:Quizartinib
3710:Pemigatinib
3690:Midostaurin
3665:Erdafitinib
3660:Entrectinib
3643:Parsaclisib
3591:Trilaciclib
3581:Palbociclib
3576:Dalpiciclib
3571:Abemaciclib
3473:Aflibercept
3400:Entrectinib
3370:Selumetinib
3365:Cobimetinib
3360:Binimetinib
3344:Ruxolitinib
3334:Momelotinib
3314:Baricitinib
3212:inhibitors:
3189:Pralsetinib
3185:Pemigatinib
3173:Futibatinib
3169:Entrectinib
3166:inhibitors:
3098:Regorafenib
3002:Avapritinib
2948:Rociletinib
2943:Osimertinib
2908:Dacomitinib
2846:Toripalimab
2831:Teclistamab
2821:Talquetamab
2816:Tafasitamab
2811:Sugemalimab
2806:Serplulimab
2796:Sabatolimab
2786:Ramucirumab
2781:Prolgolimab
2751:Necitumumab
2706:Epcoritamab
2686:Dostarlimab
2676:Daratumumab
2631:Amivantamab
2596:Alemtuzumab
2586:Brentuximab
2576:Tositumomab
2551:Ibritumomab
2532:Elranatamab
2495:Bevacizumab
2483:Edrecolomab
2478:Catumaxomab
2440:Trastuzumab
2424:Panitumumab
2329:"Erlotinib"
2309:23 December
2279:23 December
2269:GaBI Online
1832:Lung Cancer
1397:18 December
1365:18 December
1316:23 December
1282:12 November
1237:23 December
1177:23 December
982:pneumonitis
878:gemcitabine
833:Lung cancer
666: g·mol
609:100.216.020
394:183321-74-6
347:Identifiers
100:MedlinePlus
73:Other names
64:Trade names
6741:Categories
6482:Vandetanib
6447:Rebastinib
6442:Pegaptanib
6432:Nintedanib
6422:Lenvatinib
6387:Agerafenib
6340:Ripretinib
6265:CH-7057288
6164:CH-7057288
6029:7,8,3'-THF
6024:7,8,2'-THF
5950:Ranevetmab
5940:Fulranumab
5894:Rebastinib
5839:CH-7057288
5754:Cenegermin
5639:Agerafenib
5599:Agerafenib
5580:Vandetanib
5549:Vandetanib
5518:Vandetanib
5487:Vandetanib
5432:Olaratumab
5407:Ripretinib
5387:Nintedanib
5372:Lenvatinib
5362:Crenolanib
5347:Agerafenib
5266:Ranevetmab
5256:Fulranumab
5173:Cenegermin
5147:LNGF (p75)
5069:Xentuzumab
5031:Xentuzumab
4976:NVP-AEW541
4971:NVP-ADW742
4966:Linsitinib
4961:BMS-754807
4946:Mecasermin
4845:Tivantinib
4835:PHA-665752
4830:PF-2341066
4800:Golvatinib
4790:Crizotinib
4785:Capmatinib
4775:BMS-777607
4770:Amuvatinib
4646:Ersofermin
4609:Sprifermin
4565:Ersofermin
4514:Sprifermin
4504:Repifermin
4499:Palifermin
4432:Ersofermin
4411:Velafermin
4396:Repifermin
4349:Ersofermin
4268:ErbB4/HER4
4253:Patritumab
4214:ErbB3/HER3
4194:Mubritinib
4154:Pertuzumab
4127:ErbB2/HER2
4057:Vandetanib
4012:Canertinib
4007:Brigatinib
4002:Agerafenib
3982:Nepidermin
3977:Murodermin
3967:Epiregulin
3922:EGF (ErbB)
3880:Nesvacumab
3874:Evinacumab
3864:Rebastinib
3805:modulators
3760:Venetoclax
3755:Vandetanib
3730:Ripretinib
3695:Nintedanib
3680:Lenvatinib
3655:Capmatinib
3638:Idelalisib
3628:Copanlisib
3601:inhibitors
3586:Ribociclib
3557:Vismodegib
3542:inhibitors
3522:Everolimus
3488:prohibitin
3405:Lorlatinib
3395:Crizotinib
3375:Trametinib
3339:Pacritinib
3324:Filgotinib
3319:Fedratinib
3223:Crizotinib
3219:Capmatinib
3201:Vandetanib
3149:Brigatinib
3128:Vandetanib
3088:Nintedanib
3083:Lenvatinib
3022:Ripretinib
2953:Vandetanib
2928:Lazertinib
2903:Brigatinib
2826:Tarlatamab
2761:Olaratumab
2721:Isatuximab
2716:Ipilimumab
2696:Elotuzumab
2691:Durvalumab
2671:Cemiplimab
2661:Bermekimab
2651:Axatilimab
2566:Ofatumumab
2546:Glofitamab
2528:Glofitamab
2436:Pertuzumab
2227:10 January
1914:(17): 3–4.
1629:10 January
1149:References
851:metastatic
760:medication
671:3D model (
659:Molar mass
499:J4T82NDH7E
470:ChemSpider
430:IUPHAR/BPS
385:CAS Number
356:IUPAC name
321:36.2 hrs (
293:Metabolism
6507:Icrucumab
6487:WHI-P 154
6477:Tivozanib
6472:Toceranib
6467:Sunitinib
6462:Sorafenib
6457:Semaxanib
6437:Pazopanib
6427:Motesanib
6417:Lapatinib
6407:Cediranib
6345:Telbermin
6332:Agonists:
6280:GZ-389988
6260:CE-245677
6227:Agonists:
6179:GZ-389988
6159:CE-245677
6059:Diosmetin
5996:Agonists:
5962:Aptamers:
5955:Tanezumab
5930:Fasinumab
5874:Milciclib
5854:GZ-389988
5834:CE-245677
5736:Agonists:
5689:Toceranib
5684:Sunitinib
5679:Sorafenib
5669:Pazopanib
5664:Nilotinib
5659:Masitinib
5649:Dasatinib
5621:Agonists:
5567:Agonists:
5536:Agonists:
5505:Agonists:
5477:Liatermin
5469:Agonists:
5452:RET (GFL)
5442:Tovetumab
5422:Toceranib
5417:Sorafenib
5412:Sunitinib
5397:Radotinib
5392:Pazopanib
5382:Motesanib
5377:Masitinib
5312:Agonists:
5278:Aptamers:
5271:Tanezumab
5246:Fasinumab
5155:Agonists:
5011:Ganitumab
4931:IGF-1 LR3
4850:Volitinib
4805:INCB28060
4795:Foretinib
4701:Agonists:
4685:Trafermin
4643:Agonists:
4624:Burosumab
4614:Trafermin
4562:Agonists:
4529:Aprutumab
4519:Trafermin
4481:10 (KGF2)
4429:Agonists:
4406:Trafermin
4386:10 (KGF2)
4346:Agonists:
4276:Agonists:
4222:Agonists:
4204:Tucatinib
4199:Neratinib
4189:Lapatinib
4097:Matuzumab
4087:Futuximab
4072:Cetuximab
4062:WHI-P 154
4047:Neratinib
4042:Lapatinib
4032:Grandinin
4027:Gefitinib
4022:Erlotinib
3899:Agonists:
3859:CE-245677
3821:Agonists:
3750:Tepotinib
3740:Sunitinib
3735:Sorafenib
3705:Pazopanib
3685:Masitinib
3633:Duvelisib
3623:Alpelisib
3611:Sotorasib
3606:Adagrasib
3552:Sonidegib
3547:Glasdegib
3493:Adipotide
3426:Ibrutinib
3299:Dasatinib
3294:Bosutinib
3279:Radotinib
3274:Ponatinib
3269:Nilotinib
3259:Dasatinib
3254:Bosutinib
3249:Asciminib
3217:(VEGFR),
3175:(FGFR2),
3154:Ceritinib
3144:Alectinib
3123:Toceranib
3118:Tivozanib
3113:Sunitinib
3108:Sorafenib
3103:Semaxanib
3093:Pazopanib
3073:Cediranib
3037:Toceranib
3032:Sunitinib
3027:Sorafenib
3017:Pazopanib
3012:Masitinib
2979:Tucatinib
2974:Neratinib
2969:Lapatinib
2938:Olmutinib
2918:Gefitinib
2913:Erlotinib
2888:HER1/EGFR
2756:Nivolumab
2746:Naxitamab
2571:Rituximab
2419:Cetuximab
2414:HER1/EGFR
2217:GenomeWeb
1272:Drugs.com
1167:Drugs.com
1127:Genentech
1115:homodimer
1095:gefitinib
1085:Mechanism
954:effects."
860:regimen.
807:pregnancy
805:. Use in
752:Erlotinib
559:ChEMBL553
339:, 9% via
331:Excretion
316:half-life
170:Routes of
144:Pregnancy
133:Erlotinib
92:Monograph
86:Drugs.com
34:Erlotinib
6731:Medicine
6689:instead)
6678:Renalase
6639:instead)
6610:instead)
6557:instead)
6397:Axitinib
6366:D (FIGF)
6310:PLX-7486
6300:ONO-4474
6255:AZD-6918
6209:PLX-7486
6199:ONO-4474
6154:AZD-6918
6136:Ligands:
6054:Deprenyl
6014:7,3'-DHF
5945:MEDI-578
5925:ASP-6294
5889:PLX-7486
5879:ONO-4474
5829:AZD-6918
5789:ALE-0540
5710:instead.
5654:Imatinib
5644:Axitinib
5624:Ancestim
5589:Unsorted
5367:Imatinib
5357:Axitinib
5261:MEDI-578
5241:ASP-6294
5208:ALE-0540
5050:Agonists
4991:AVE-1642
4917:Agonists
4840:SU-11274
4726:Agonists
4704:FGF15/19
4694:Unsorted
4659:2 (bFGF)
4578:2 (bFGF)
4445:2 (bFGF)
4362:2 (bFGF)
4184:Afatinib
4135:Agonists
4037:Icotinib
3997:Afatinib
3943:Agonists
3540:hedgehog
3502:against
3500:exotoxin
3466:against
3415:Bruton's
3264:Imatinib
3187:(FGFR),
3183:(NTRK),
3068:Axitinib
3007:Axitinib
2963:HER2/neu
2923:Icotinib
2893:Afatinib
2867:("-nib")
2646:Avelumab
2518:lymphoid
2510:lymphoma
2506:Leukemia
2431:HER2/neu
2393:("-mab")
2303:Archived
2273:Archived
2221:Archived
2199:12848590
2164:10555942
2156:11129168
2100:24807167
2051:24643910
2002:22889962
1961:20382753
1893:15310767
1852:16290256
1816:18093943
1757:23254145
1749:17463250
1700:17085664
1652:archived
1623:Archived
1601:23244131
1557:23361373
1508:10218263
1500:16079312
1459:36267895
1388:Archived
1310:Archived
1276:Archived
1231:Archived
1226:DailyMed
1171:Archived
958:Diarrhea
902:imatinib
817:(EGFR).
780:by mouth
742:(verify)
450:DrugBank
304:, less
300:(mainly
184:ATC code
177:By mouth
146:category
128:DailyMed
6566:Ephrins
6270:DS-6051
6169:DS-6051
6074:LM22A-4
6064:DMAQ-B1
6019:7,8-DHF
5999:3,7-DHF
5968:RBM-004
5913:GBR-900
5844:DS-6051
5814:VM-902A
5284:RBM-004
4981:OSl-906
4941:Insulin
4820:MK-2461
4765:AMG-458
3902:Axokine
3243:bcr-abl
2604:myeloid
2091:4407688
2042:4407685
1952:3202369
1807:2409244
1784:Bibcode
1727:Bibcode
1719:Science
1658:18 June
1548:3591525
1450:9574558
1107:mutated
1101:(EGFR)
986:dyspnea
966:Fatigue
866:Genzyme
756:Tarceva
664:393.443
626:Formula
459:DB00530
405:PubChem
200:)
194: (
192:L01EB02
159: C
130::
106:a605008
68:Tarceva
18:Tarceva
6757:Ethers
6747:Amines
6717:Portal
6536:Others
6230:BNN-20
6119:ANA-12
6044:BNN-20
5764:DHEA-S
5749:BNN-27
5744:BNN-20
5183:DHEA-S
5168:BNN-27
5163:BNN-20
5079:Others
4284:Epigen
3962:Epigen
2490:VEGF-A
2197:
2162:
2154:
2098:
2088:
2049:
2039:
2000:
1959:
1949:
1891:
1850:
1814:
1804:
1755:
1747:
1698:
1599:
1555:
1545:
1506:
1498:
1457:
1447:
1419:versus
1075:CYP3A4
1044:(BOOP)
936:Common
801:, and
799:stroke
697:SMILES
550:ChEMBL
519:D07907
479:154044
419:176870
323:median
306:CYP1A2
302:CYP3A4
255:℞-only
253:
240:
227:
126:
6685:(see
6635:(see
6606:(see
6553:(see
6285:K252a
6184:K252a
5859:K252a
5799:FX007
5559:GFRα4
5528:GFRα3
5497:GFRα2
5461:GFRα1
5089:IGFBP
5042:IGF-2
5021:R1507
4909:IGF-1
4815:K252a
4635:FGFR4
4554:FGFR3
4421:FGFR2
4338:FGFR1
3484:ANXA2
3456:Other
3354:MAP2K
3225:(ALK)
3210:c-MET
3062:VEGFR
2997:PDGFR
2993:C-kit
2624:Other
2473:EpCAM
2160:S2CID
2134:Drugs
1753:S2CID
1619:Roche
1504:S2CID
1391:(PDF)
1384:(PDF)
1306:(FDA)
1302:U.S.
1143:Cipla
1135:Roche
1068:OATPs
921:ERBB3
910:T790M
717:InChI
673:JSmol
530:ChEBI
341:urine
337:feces
298:Liver
6687:here
6637:here
6608:here
6555:here
6350:VEGF
6324:VEGF
6240:NT-3
6235:DHEA
6219:TrkC
6139:DHEA
6109:TDP6
6089:NT-4
6084:NT-3
6069:HIOC
6039:BDNF
5988:TrkB
5759:DHEA
5728:TrkA
5708:here
5706:See
5699:TGFβ
5304:PDGF
5198:NT-4
5193:NT-3
5178:DHEA
5158:BDNF
3907:CNTF
3891:CNTF
3599:KRAS
3504:IL-2
3486:and
3468:VEGF
3385:EML4
3044:FLT3
2995:and
2883:ErbB
2609:CD33
2591:CD52
2581:CD30
2541:CD20
2409:ErbB
2311:2019
2281:2019
2229:2020
2195:PMID
2152:PMID
2096:PMID
2047:PMID
1998:PMID
1957:PMID
1889:PMID
1848:PMID
1812:PMID
1745:PMID
1696:PMID
1660:2009
1631:2020
1597:PMID
1553:PMID
1496:PMID
1455:PMID
1423:EGFR
1399:2010
1367:2010
1318:2019
1284:2019
1239:2019
1179:2019
1129:and
975:Rare
942:Rash
925:PI3K
510:KEGG
490:UNII
439:4920
267:data
82:AHFS
6104:R13
5774:NGF
5719:Trk
5188:NGF
4900:IGF
4760:AM7
4651:FGF
4570:FGF
4471:),
4469:KGF
4437:FGF
4354:FGF
4329:FGF
3931:EGF
3389:ALK
3289:Src
3164:RET
3138:ALK
2588:),
2578:),
2538:),
2523:CD3
2379:L01
2187:doi
2142:doi
2086:PMC
2078:doi
2037:PMC
2029:doi
1988:doi
1947:PMC
1939:doi
1879:doi
1840:doi
1802:PMC
1792:doi
1780:104
1735:doi
1723:316
1686:doi
1587:doi
1543:PMC
1535:doi
1486:doi
1445:PMC
1437:doi
1337:hdl
912:).
906:CML
904:in
575:EPA
409:CID
287:95%
277:59%
242:POM
197:WHO
6743::
6598:B3
6596:,
6594:B2
6592:,
6590:B1
6588:,
6586:A5
6584:,
6582:A4
6580:,
6578:A3
6576:,
6574:A2
6572:,
6570:A1
6364:,
6360:,
6356:,
6099:R7
5915:;
5334:,
5330:,
5326:,
5115:,
5111:,
5107:,
5103:,
5099:,
5095:,
5052::
4919::
4728::
4679:19
4677:,
4673:,
4669:,
4665:,
4661:,
4657:,
4598:23
4596:,
4594:18
4592:,
4588:,
4584:,
4580:,
4576:,
4493:22
4491:,
4489:18
4487:,
4485:17
4483:,
4479:,
4475:,
4463:,
4459:,
4455:,
4451:,
4447:,
4443:,
4390:20
4388:,
4384:,
4380:,
4376:,
4372:,
4368:,
4364:,
4360:,
4312:,
4308:,
4304:,
4300:,
4235:,
4231:,
4137::
3945::
3221:,
3191:,
3179:,
3051:,
2990::
2885::
2606::
2534:,
2530:,
2520::
2438:,
2411::
2388:CI
2373:/
2331:.
2297:.
2267:.
2245:.
2215:.
2193:.
2181:.
2158:.
2150:.
2138:60
2136:.
2132:.
2094:.
2084:.
2074:29
2072:.
2068:.
2045:.
2035:.
2025:29
2023:.
2019:.
1996:.
1984:84
1982:.
1978:.
1955:.
1945:.
1935:38
1933:.
1929:.
1910:.
1887:.
1875:22
1873:.
1869:.
1846:.
1836:51
1834:.
1810:.
1800:.
1790:.
1778:.
1774:.
1751:.
1743:.
1733:.
1721:.
1717:.
1694:.
1682:12
1680:.
1676:.
1650:,
1617:.
1595:.
1583:13
1581:.
1577:.
1565:^
1551:.
1541:.
1529:.
1525:.
1502:.
1494:.
1482:10
1480:.
1476:.
1453:.
1443:.
1431:.
1427:.
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1386:.
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1270:.
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1198:.
1187:^
1165:.
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927:.
884:.
868:.
824:.
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793:,
789:,
782:.
640:23
634:22
249:US
236:UK
229:S4
223:AU
155:AU
123:US
6719::
6631:/
6600:)
6568:(
6368:)
6362:C
6358:B
6354:A
6352:(
5901:)
5338:)
5336:D
5332:C
5328:B
5324:A
5322:(
5119:)
5117:7
5113:6
5109:5
5105:4
5101:3
5097:2
5093:1
5091:(
4681:)
4675:9
4671:8
4667:6
4663:4
4655:1
4653:(
4600:)
4590:9
4586:8
4582:4
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4572:(
4495:)
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4473:8
4467:(
4465:7
4461:6
4457:5
4453:4
4449:3
4441:1
4439:(
4392:)
4382:8
4378:6
4374:5
4370:4
4366:3
4358:1
4356:(
4316:)
4310:4
4306:3
4302:2
4298:1
4296:(
4239:)
4233:2
4229:1
4227:(
3794:e
3787:t
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3507:(
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3471:(
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3301:)
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3047:(
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3000:(
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2638:(
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2594:(
2584:(
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2526:(
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2497:)
2493:(
2485:)
2476:(
2457:)
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2442:(
2434:(
2426:)
2417:(
2381:)
2377:(
2363:e
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2335:.
2313:.
2283:.
2231:.
2201:.
2189::
2183:4
2166:.
2144::
2102:.
2080::
2053:.
2031::
2004:.
1990::
1963:.
1941::
1912:1
1895:.
1881::
1854:.
1842::
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1737::
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1702:.
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1633:.
1603:.
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1537::
1531:8
1510:.
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1461:.
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1369:.
1343:.
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1320:.
1286:.
1241:.
1181:.
1017:/
675:)
652:4
649:O
646:3
643:N
637:H
631:C
577:)
573:(
367:N
325:)
308:)
251::
238::
225::
157::
84:/
20:)
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