722:
2679:
higher in women. During the same time frame, the in-hospital case fatality rate was reduced from 28% to 18%. However, according to the nationwide inpatient sample from the United States, the incidence of severe sepsis increased from 200 per 10,000 population in 2003 to 300 cases in 2007 for population aged more than 18 years. The incidence rate is particularly high among infants, with an incidence of 500 cases per 100,000 population. Mortality related to sepsis increases with age, from less than 10% in the age group of 3 to 5 years to 60% by sixth decade of life. The increase in the average age of the population, alongside the presence of more people with chronic diseases or on
2692:
1472:(CHEST) raised concerns that qSOFA and SOFA criteria may lead to delayed diagnosis of serious infection, leading to delayed treatment. Although SIRS criteria can be too sensitive and not specific enough in identifying sepsis, SOFA also has its limitations and is not intended to replace the SIRS definition. qSOFA has also been found to be poorly sensitive though decently specific for the risk of death with SIRS possibly better for screening. NOTE - Surviving Sepsis Campaign 2021 Guidelines recommends "against using qSOFA compared with SIRS, NEWS, or MEWS as a single screening tool for sepsis or septic shock".
9464:
1468:). The three criteria for the qSOFA score include a respiratory rate greater than or equal to 22 breaths per minute, systolic blood pressure 100 mmHg or less and altered mental status. Sepsis is suspected when 2 of the qSOFA criteria are met. The SOFA score was intended to be used in the intensive care unit (ICU) where it is administered upon admission to the ICU and then repeated every 48 hours, whereas the qSOFA could be used outside the ICU. Some advantages of the qSOFA score are that it can be administered quickly and does not require labs. However, the
2433:(EGDT) is an approach to the management of severe sepsis during the initial 6 hours after diagnosis. It is a step-wise approach, with the physiologic goal of optimizing cardiac preload, afterload, and contractility. It includes giving early antibiotics. EGDT also involves monitoring of hemodynamic parameters and specific interventions to achieve key resuscitation targets which include maintaining a central venous pressure between 8–12 mmHg, a mean arterial pressure of between 65 and 90 mmHg, a central venous oxygen saturation (ScvO
2818:
as of the date of their article over 150 clinical trials of sepsis had been conducted in humans, almost all of them supported by promising data in mice and that all of them had failed. The authors called for abandoning the use of mouse models in sepsis research; others rejected that but called for more caution in interpreting the results of mouse studies, and more careful design of preclinical studies. One approach is to rely more on studying biopsies and clinical data from people who have had sepsis, to try to identify
2647:(ICU) and the tenth-most-common cause of death overall (the first being heart disease). Children under 12 months of age and elderly people have the highest incidence of severe sepsis. Among people from the U.S. who had multiple sepsis hospital admissions in 2010, those who were discharged to a skilled nursing facility or long-term care following the initial hospitalization were more likely to be readmitted than those discharged to another form of care. A study of 18 U.S. states found that, amongst people with
1906:
intravenous fluids if there is evidence of either low blood pressure or other evidence for inadequate blood supply to organs (as evidenced by a raised level of lactate); blood cultures also should be obtained within this time period. After six hours the blood pressure should be adequate, close monitoring of blood pressure and blood supply to organs should be in place, and the lactate should be measured again if initially it was raised. A related bundle, the "
55:
1219:
591:
1392:
2333:(PEEP) is recommended for moderate to severe ARDS in sepsis as it opens more lung units for oxygen exchange. Predicted body weight is calculated based on sex and height, and tools for this are available. Recruitment maneuvers may be necessary for severe ARDS by briefly raising the transpulmonary pressure. It is recommended that the head of the bed be raised if possible to improve ventilation. However,
2234:
hypotensive shock because it reduces blood flow to the abdominal organs and increases lactate levels. Vasopressin can be used in septic shock because studies have shown that there is a relative deficiency of vasopressin when shock continues for 24 to 48 hours. However, vasopressin reduces blood flow to the heart, finger/toes, and abdominal organs, resulting in a lack of oxygen supply to these tissues.
1809:(SuPAR) is a nonspecific marker of inflammation and does not accurately diagnose sepsis. This same review concluded, however, that SuPAR has prognostic value, as higher SuPAR levels are associated with an increased rate of death in those with sepsis. Serial measurement of lactate levels (approximately every 4 to 6 hours) may guide treatment and is associated with lower mortality in sepsis.
583:, approximately 0.2 to 3 people per 1000 are affected by sepsis yearly, resulting in about a million cases per year in the United States. Rates of disease have been increasing. Some data indicate that sepsis is more common among males than females, however, other data show a greater prevalence of the disease among women. Descriptions of sepsis date back to the time of
2875:
1990:) are recommended. The choice of antibiotics is important in determining the survival of the person. Some recommend they be given within one hour of making the diagnosis, stating that for every hour of delay in the administration of antibiotics, there is an associated 6% rise in mortality. Others did not find a benefit with early administration.
2860:" was established in 2002 to educate people about sepsis and to improve outcomes with sepsis. The Campaign has published an evidence-based review of management strategies for severe sepsis, with the aim to publish a complete set of guidelines in subsequent years. The guidelines were updated in 2016 and again in 2021.
2614:
and
Mortality in Emergency Department Sepsis. APACHE II factors in the person's age, underlying condition, and various physiologic variables to yield estimates of the risk of dying of severe sepsis. Of the individual covariates, the severity of the underlying disease most strongly influences the risk
2514:
to bring it down to 7.8–10 mmol/L (140–180 mg/dL) is recommended with lower levels potentially worsening outcomes. Glucose levels taken from capillary blood should be interpreted with care because such measurements may not be accurate. If a person has an arterial catheter, arterial blood is
1965:
Two sets of blood cultures (aerobic and anaerobic) are recommended without delaying the initiation of antibiotics. Cultures from other sites such as respiratory secretions, urine, wounds, cerebrospinal fluid, and catheter insertion sites (in-situ more than 48 hours) are recommended if infections from
708:
also decreases, causing a narrowing/decreasing of pulse pressure. A pulse pressure of over 70 mmHg in patients with sepsis is correlated with an increased chance of survival. A widened pulse pressure is also correlated with an increased chance that someone with sepsis will benefit from and respond to
6212:
Serpa Neto A, Veelo DP, Peireira VG, de Assunção MS, Manetta JA, Espósito DC, Schultz MJ (February 2014). "Fluid resuscitation with hydroxyethyl starches in patients with sepsis is associated with an increased incidence of acute kidney injury and use of renal replacement therapy: a systematic review
2233:
and heart rate. In some people, the required dose of vasopressor needed to increase the mean arterial pressure can become exceedingly high that it becomes toxic. In order to reduce the required dose of vasopressor, epinephrine may be added. Epinephrine is not often used as a first-line treatment for
2087:
is sufficient to achieve peak plasma concentration for a clinical response without kidney toxicity. Meanwhile, for antibiotics with low volume distribution (vancomycin, teicoplanin, colistin), a loading dose is required to achieve an adequate therapeutic level to fight infections. Frequent infusions
1399:
Previously, SIRS criteria had been used to define sepsis. If the SIRS criteria are negative, it is very unlikely the person has sepsis; if it is positive, there is just a moderate probability that the person has sepsis. According to SIRS, there were different levels of sepsis: sepsis, severe sepsis,
2817:
Controversy occurred in the scientific community over the use of mouse models in research into sepsis in 2013 when scientists published a review of the mouse immune system compared to the human immune system and showed that on a systems level, the two worked very differently; the authors noted that
2809:
gene 4 (TLR 4). Genetic mapping work, performed over a period of five years, showed that TLR4 was the sole candidate locus within the Lps critical region; this strongly implied that a mutation within TLR4 must account for the lipopolysaccharide resistance phenotype. The defect in the TLR4 gene that
2448:
In the original trial, early goal-directed therapy was found to reduce mortality from 46.5% to 30.5% in those with sepsis, and the
Surviving Sepsis Campaign has been recommending its use. However, three more recent large randomized control trials (ProCESS, ARISE, and ProMISe), did not demonstrate a
2267:
only if both intravenous fluids and vasopressors are not able to adequately treat septic shock. The 2021 Surviving Sepsis
Campaign recommends IV corticosteroids for adults with septic shock who have an ongoing requirement for vasopressor therapy. A 2019 Cochrane review found low-quality evidence of
1998:
or community-acquired infection, and which organ systems are thought to be infected. Antibiotic regimens should be reassessed daily and narrowed if appropriate. Treatment duration is typically 7–10 days with the type of antibiotic used directed by the results of cultures. If the culture result
6743:
Marik PE, Pastores SM, Annane D, Meduri GU, Sprung CL, Arlt W, et al. (June 2008). "Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the
American College of Critical Care
2638:
Sepsis occurs in 1–2% of all hospitalizations and accounts for as much as 25% of ICU bed utilization. Due to it rarely being reported as a primary diagnosis (often being a complication of cancer or other illness), the incidence, mortality, and morbidity rates of sepsis are likely underestimated. A
2839:
Sepsis was the most expensive condition treated in United States' hospital stays in 2013, at an aggregate cost of $ 23.6 billion for nearly 1.3 million hospitalizations. Costs for sepsis hospital stays more than quadrupled since 1997 with an 11.5 percent annual increase. By payer, it was the most
2304:
levels are recommended to confirm the diagnosis. The method of stopping glucocorticoid drugs is variable, and it is unclear whether they should be slowly decreased or simply abruptly stopped. However, the 2016 Surviving Sepsis
Campaign recommended to taper steroids when vasopressors are no longer
2121:
reaches 8–12 mmHg. Once these goals are met, the central venous oxygen saturation (ScvO2), i.e., the oxygen saturation of venous blood as it returns to the heart as measured at the vena cava, is optimized. If the ScvO2 is less than 70%, blood may be given to reach a hemoglobin of 10 g/dL and
1801:
of the test to be 77% and the specificity to be 79%. The authors suggested that procalcitonin may serve as a helpful diagnostic marker for sepsis, but cautioned that its level alone does not definitively make the diagnosis. More current literature recommends utilizing the PCT to direct antibiotic
2606:
Sepsis will prove fatal in approximately 24.4% of people, and septic shock will prove fatal in 34.7% of people within 30 days (32.2% and 38.5% after 90 days). Lactate is a useful method of determining prognosis, with those who have a level greater than 4 mmol/L having a mortality of 40% and
2246:
can also be used in hypotensive septic shock to increase cardiac output and correct blood flow to the tissues. Dobutamine is not used as often as epinephrine due to its associated side effects, which include reducing blood flow to the gut. Additionally, dobutamine increases the cardiac output by
2678:
From 1979 to 2000, data from the United States
National Hospital Discharge Survey showed that the incidence of sepsis increased fourfold, to 240 cases per 100,000 population, with a higher incidence in men when compared to women. However, the global prevalence of sepsis has been estimated to be
1898:
2615:
of death. Septic shock is also a strong predictor of short- and long-term mortality. Case-fatality rates are similar for culture-positive and culture-negative severe sepsis. The
Mortality in Emergency Department Sepsis (MEDS) score is simpler and useful in the emergency department environment.
337:
10 to 80% risk of death; These mortality rates (they are for a range of conditions along a spectrum: sepsis, severe sepsis, and septic shock) may be lower if treated aggressively and early, depending on the organism and disease, the patient's previous health, and the abilities of the treatment
2460:
can be difficult to diagnose as newborns may be asymptomatic. If a newborn shows signs and symptoms suggestive of sepsis, antibiotics are immediately started and are either changed to target a specific organism identified by diagnostic testing or discontinued after an infectious cause for the
1905:
Early recognition and focused management may improve the outcomes in sepsis. Current professional recommendations include a number of actions ("bundles") to be followed as soon as possible after diagnosis. Within the first three hours, someone with sepsis should have received antibiotics and,
2228:
Norepinephrine is often used as a first-line treatment for hypotensive septic shock because evidence shows that there is a relative deficiency of vasopressin when shock continues for 24 to 48 hours. Norepinephrine raises blood pressure through a vasoconstriction effect, with little effect on
2184:
transfusion usually does not correct the underlying clotting abnormalities before a planned surgical procedure. However, platelet transfusion is suggested for platelet counts below (10 × 10/L) without any risk of bleeding, or (20 × 10/L) with high risk of bleeding, or (50 × 10/L) with active
594:
597:
596:
592:
598:
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symptoms has been ruled out. Despite early intervention, death occurs in 13% of children who develop septic shock, with the risk partly based on other health problems. For those without multiple organ system failures or who require only one inotropic agent, mortality is low.
2597:
People in sepsis may have micronutrient deficiencies, including low levels of vitamin C. Reviews mention that an intake of 3.0 g/day, which requires intravenous administration, may needed to maintain normal plasma concentrations in people with sepsis or severe burn injury.
578:
Disease severity partly determines the outcome. The risk of death from sepsis is as high as 30%, while for severe sepsis it is as high as 50%, and septic shock 80%. Sepsis affected about 49 million people in 2017, with 11 million deaths (1 in 5 deaths worldwide). In the
599:
864:
The most common sites of infection resulting in severe sepsis are the lungs, the abdomen, and the urinary tract. Typically, 50% of all sepsis cases start as an infection in the lungs. In one-third to one-half of cases, the source of infection is unclear.
5451:
Fernando SM, Tran A, Taljaard M, Cheng W, Rochwerg B, Seely AJ, Perry JJ (February 2018). "Prognostic
Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis".
595:
2498:
score), where it was thought to confer a survival benefit. However, subsequent studies showed that it increased adverse events—bleeding risk in particular—and did not decrease mortality. It was removed from sale in 2011. Another medication known as
2449:
90-day mortality benefit of early goal-directed therapy when compared to standard therapy in severe sepsis. It is likely that some parts of EGDT are more important than others. Following these trials the use of EGDT is still considered reasonable.
469:(qSOFA), replaced the SIRS system of diagnosis. qSOFA criteria for sepsis include at least two of the following three: increased breathing rate, change in the level of consciousness, and low blood pressure. Sepsis guidelines recommend obtaining
2618:
Some people may experience severe long-term cognitive decline following an episode of severe sepsis, but the absence of baseline neuropsychological data in most people with sepsis makes the incidence of this difficult to quantify or to study.
2726:(ICD) version 9, which was in use in the US until 2013, used the term septicemia with numerous modifiers for different diagnoses, such as "Streptococcal septicemia". All those diagnoses have been converted to sepsis, again with modifiers, in
2172:, or acute bleeding. In a 2014 trial, blood transfusions to keep target hemoglobin above 70 or 90 g/L did not make any difference to survival rates; meanwhile, those with a lower threshold of transfusion received fewer transfusions in total.
2395:
cases remains controversial. When appropriately used, paralytics may aid successful mechanical ventilation, however, evidence has also suggested that mechanical ventilation in severe sepsis does not improve oxygen consumption and delivery.
5983:
Roberts JA, Abdul-Aziz MH, Davis JS, Dulhunty JM, Cotta MO, Myburgh J, et al. (September 2016). "Continuous versus
Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials".
2352:
General anesthesia is recommended for people with sepsis who require surgical procedures to remove the infective source. Usually, inhalational and intravenous anesthetics are used. Requirements for anesthetics may be reduced in sepsis.
873:
Sepsis is caused by a combination of factors related to the particular invading pathogen(s) and to the status of the immune system of the host. The early phase of sepsis characterized by excessive inflammation (sometimes resulting in a
2984:. Marik's own initial research, published in 2017, showed a dramatic evidence of benefit, leading to the protocol becoming popular among intensive care physicians, especially after the protocol received attention on social media and
8901:
1269:. If other sources of infection are suspected, cultures of these sources, such as urine, cerebrospinal fluid, wounds, or respiratory secretions, also should be obtained, as long as this does not delay the use of antibiotics.
8666:
Poltorak A, Smirnova I, He X, Liu MY, Van Huffel C, McNally O, et al. (September 1998). "Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region".
2654:
Several medical conditions increase a person's susceptibility to infection and developing sepsis. Common sepsis risk factors include age (especially the very young and old); conditions that weaken the immune system such as
6904:
Gu WJ, Wang F, Tang L, Liu JC (February 2015). "Single-dose etomidate does not increase mortality in patients with sepsis: a systematic review and meta-analysis of randomized controlled trials and observational studies".
4594:"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine"
2437:) greater than 70% and a urine output of greater than 0.5 mL/kg/hour. The goal is to optimize oxygen delivery to tissues and achieve a balance between systemic oxygen delivery and demand. An appropriate decrease in serum
7227:
Rusconi AM, Bossi I, Lampard JG, Szava-Kovats M, Bellone A, Lang E (September 2015). "Early goal-directed therapy vs usual care in the treatment of severe sepsis and septic shock: a systematic review and meta-analysis".
2349:(CPAP), T piece, or inspiratory pressure augmentation can be helpful in reducing the duration of ventilation. Minimizing intermittent or continuous sedation is helpful in reducing the duration of mechanical ventilation.
1889:, but neonatal sepsis also may be due to infection with fungi, viruses, or parasites. Criteria with regard to hemodynamic compromise or respiratory failure are not useful because they present too late for intervention.
1241:, measuring serum lactate, and obtaining appropriate cultures before starting antibiotics, so long as this does not delay their use by more than 45 minutes. To identify the causative organism(s), at least two sets of
5111:
9592:
9565:
9546:
2723:
2554:(UGIB) such as on mechanical ventilation for more than 48 hours, coagulation disorders, liver disease, and renal replacement therapy. Achieving partial or full enteral feeding (delivery of nutrients through a
1993:
Several factors determine the most appropriate choice for the initial antibiotic regimen. These factors include local patterns of bacterial sensitivity to antibiotics, whether the infection is thought to be a
7932:
Carpenter CR, Keim SM, Upadhye S, Nguyen HB (October 2009). "Risk stratification of the potentially septic patient in the emergency department: the
Mortality in the Emergency Department Sepsis (MEDS) score".
2108:
has recommended 30 mL/kg of fluid to be given in adults in the first three hours followed by fluid titration according to blood pressure, urine output, respiratory rate, and oxygen saturation with a target
2295:
is unclear. However, the exact way of determining corticosteroid insufficiency remains problematic. It should be suspected in those poorly responding to resuscitation with fluids and vasopressors. Neither
5439:
We hope this editorial will clarify that the qSOFA is meant to be used to raise suspicion of sepsis and prompt further action—it is not a replacement for SIRS and is not part of the definition of sepsis.
4781:
Leentjens J, Kox M, van der Hoeven JG, Netea MG, Pickkers P (June 2013). "Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change?".
1914:; this requires the administration of antibiotics within an hour of recognition, blood cultures, lactate, and hemoglobin determination, urine output monitoring, high-flow oxygen, and intravenous fluids.
5384:
We believe that adopting a more restrictive definition that requires further progression along the sepsis pathway may delay intervention in this highly time-dependent condition, with additional risk to
1999:
is negative, antibiotics should be de-escalated according to the person's clinical response or stopped altogether if an infection is not present to decrease the chances that the person is infected with
2205:, plasma filtration, and coupled plasma filtration adsorption) to remove inflammatory mediators and bacterial toxins from the blood also does not demonstrate any survival benefit for septic shock.
2469:
Treating fever in sepsis, including people in septic shock, has not been associated with any improvement in mortality over a period of 28 days. Treatment of fever still occurs for other reasons.
2894:
microbial response to a sudden decline of host survival chances. Under this scenario, the microbe species provoking sepsis benefit from monopolizing the future cadaver, utilizing its biomass as
1287:
Within twelve hours, it is essential to diagnose or exclude any source of infection that would require emergent source control, such as a necrotizing soft tissue infection, an infection causing
1520:
symptoms including agitation, confusion, coma; causes may include ischemia, bleeding, formation of blood clots in small blood vessels, microabscesses, multifocal necrotizing leukoencephalopathy
593:
6124:"Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis"
882:. Either of these phases may prove fatal. On the other hand, systemic inflammatory response syndrome (SIRS) occurs in people without the presence of infection, for example, in those with
2558:) is chosen as the best approach to provide nutrition for a person who is contraindicated for oral intake or unable to tolerate orally in the first seven days of sepsis when compared to
2185:
bleeding, before a planned surgery or an invasive procedure. IV immunoglobulin is not recommended because its beneficial effects are uncertain. Monoclonal and polyclonal preparations of
2148:, and need for blood transfusion. Various colloid solutions (such as modified gelatin) carry no advantage over crystalloid. Albumin also appears to be of no benefit over crystalloids.
8893:
7355:
Kutko MC, Calarco MP, Flaherty MB, Helmrich RF, Ushay HM, Pon S, Greenwald BM (July 2003). "Mortality rates in pediatric septic shock with and without multiple organ system failure".
672:
that may lead to organ failure. Fever is the most common presenting symptom in sepsis, but fever may be absent in some people such as the elderly or those who are immunocompromised.
2992:
from the wider medical community. Subsequent independent research failed to replicate Marik's positive results, indicating the possibility that they had been compromised by bias. A
9489:
1211:
Early diagnosis is necessary to properly manage sepsis, as the initiation of rapid therapy is key to reducing deaths from severe sepsis. Some hospitals use alerts generated from
8017:
Lyle NH, Pena OM, Boyd JH, Hancock RE (September 2014). "Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host-directed therapies".
6695:
Ni YN, Liu YM, Wang YW, Liang BM, Liang ZA (September 2019). "Can corticosteroids reduce the mortality of patients with severe sepsis? A systematic review and meta-analysis".
7744:
Belsky JB, Wira CR, Jacob V, Sather JE, Lee PJ (December 2018). "A review of micronutrients in sepsis: the role of thiamine, L-carnitine, vitamin C, selenium and vitamin D".
1116:(yellowish discoloration of the skin). In kidneys, inadequate oxygenation results in tubular epithelial cell injury (of the cells lining the kidney tubules), and thus causes
2719:
process. Though severe systemic toxicity had already been observed, it was only in the 19th century that the specific term – sepsis – was used for this condition.
5099:
1789:
Biomarkers can help diagnosis because they can point to the presence or severity of sepsis, although their exact role in the management of sepsis remains undefined. A 2013
8702:
Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, et al. (December 1998). "Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene".
9367:
Lee YR, Vo K, Varughese JT (March 2022). "Benefits of combination therapy of hydrocortisone, ascorbic acid and thiamine in sepsis and septic shock: A systematic review".
8496:
Shear MJ (1944). "Chemical treatment of tumors, IX: Reactions of mice with primary subcutaneous tumors to injection of a hemorrhage-producing bacterial polysaccharide".
8474:
10310:
9941:
5538:
Goldstein B, Giroir B, Randolph A (January 2005). "International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics".
2280:
2805:. These mice were also found to be hyper susceptible to infection by gram-negative bacteria. These observations were finally linked in 1998 by the discovery of the
1272:
Within six hours, if blood pressure remains low despite initial fluid resuscitation of 30 mL/kg, or if initial lactate is ≥ four mmol/L (36 mg/dL),
6021:"Part 12: Pediatric Advanced Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care"
8205:
2866:
is a charitable organization based in the United States that was created to raise sepsis awareness among both the general public and healthcare professionals.
1781:
Consensus definitions, however, continue to evolve, with the latest expanding the list of signs and symptoms of sepsis to reflect clinical bedside experience.
6165:"Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis"
2225:(noradrenaline) is recommended as the initial choice. Delaying initiation of vasopressor therapy during septic shock is associated with increased mortality.
8525:
Lüderitz O, Galanos C, Lehmann V, Nurminen M, Rietschel ET, Rosenfelder G, et al. (July 1973). "Lipid A: chemical structure and biological activity".
5133:
4162:
Khilnani P, Singhi S, Lodha R, Santhanam I, Sachdev A, Chugh K, Jaishree M, Ranjit S, Ramachandran B, Ali U, Udani S, Uttam R, Deopujari S (January 2010).
1013:. Invariably, the association of a PAMP and a PRR will cause a series of intracellular signalling cascades. Consequentially, transcription factors such as
1921:, the management of sepsis also involves surgical drainage of infected fluid collections and appropriate support for organ dysfunction. This may include
7883:"Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019- results from a systematic review and meta-analysis"
2643:
found approximately 651 hospital stays per 100,000 population with a sepsis diagnosis in 2010. It is the second-leading cause of death in non-coronary
2092:(MIC), thus providing a better clinical response. Giving beta-lactam antibiotics continuously may be better than giving them intermittently. Access to
6250:"Randomised trials of human albumin for adults with sepsis: systematic review and meta-analysis with trial sequential analysis of all-cause mortality"
9701:
5805:
2794:
character of enteric endotoxins was elucidated in 1944 by Shear. The molecular character of this material was determined by Luderitz et al. in 1973.
9139:
721:
1100:
through various mechanisms as described below. Increased permeability of the lung vessels causes leaking of fluids into alveoli, which results in
6861:
Chan CM, Mitchell AL, Shorr AF (November 2012). "Etomidate is associated with mortality and adrenal insufficiency in sepsis: a meta-analysis*".
6818:
Cherfan AJ, Arabi YM, Al-Dorzi HM, Kenny LP (May 2012). "Advantages and disadvantages of etomidate use for intubation of patients with sepsis".
4218:"A widened pulse pressure: a potential valuable prognostic indicator of mortality in patients with sepsis. J Community Hosp Intern Med Perspect"
433:
Sepsis is caused by many organisms including bacteria, viruses and fungi. Common locations for the primary infection include the lungs, brain,
10396:
3816:
Desale M, Thinkhamrop J, Lumbiganon P, Qazi S, Anderson J (October 2016). "Ending preventable maternal and newborn deaths due to infection".
2377:
and an increased risk of death. The small amount of evidence there is, however, has not found a change in the risk of death with etomidate.
2722:
The terms "septicemia", also spelled "septicaemia", and "blood poisoning" referred to the microorganisms or their toxins in the blood. The
2582:
are recommended for those who are septic and unable to tolerate enteral feeding. However, these agents may precipitate prolongation of the
9507:
8068:
Munford RS (2011). "Ch. 271: Severe Sepsis and Septic Shock". In Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J (eds.).
1583:
hypotension with blood pressure < 5th percentile for age or systolic blood pressure < 2 standard deviations below normal for age, or
9979:
9116:
5886:
2020:
2072:) for less ill people. Prolonged antibiotic prophylaxis is not recommended in people who has SIRS without any infectious origin such as
9039:
8193:
8189:
8111:
3061:
2113:(MAP) of 65 mmHg. In children an initial amount of 20 mL/kg is reasonable in shock. In cases of severe sepsis and septic shock where a
1175:
The low blood pressure seen in those with sepsis is the result of various processes, including excessive production of chemicals that
6796:
1511:
1436:
is defined as sepsis with sepsis-induced organ dysfunction or tissue hypoperfusion (manifesting as hypotension, elevated lactate, or
2627:
Sepsis causes millions of deaths globally each year and is the most common cause of death in people who have been hospitalized. The
8498:
3105:
2242:
than norepinephrine and also has an immunosuppressive effect. Dopamine is not proven to have protective properties on the kidneys.
9807:
9074:
9033:
8183:
8105:
4817:
Antonopoulou A, Giamarellos-Bourboulis EJ (January 2011). "Immunomodulation in sepsis: state of the art and future perspective".
2473:
1457:
1328:
825:
accounts for approximately 5% of severe sepsis and septic shock cases; the most common cause of fungal sepsis is an infection by
481:
is helpful when looking for the possible location of the infection. Other potential causes of similar signs and symptoms include
458:
285:
1033:, the host systemic immune system is activated. Immune cells not only recognise pathogen-associated molecular patterns but also
2198:
2140:
can be used if a large amount of crystalloid is required for resuscitation. Crystalloid solutions shows little difference with
1736:
669:
117:
7789:"The outcome of IV vitamin C therapy in patients with sepsis or septic shock: a meta-analysis of randomized controlled trials"
5766:
Machowicz R, Janka G, Wiktor-Jedrzejczak W (June 2017). "Similar but not the same: Differential diagnosis of HLH and sepsis".
9694:
8461:
7016:
5903:
2845:
2096:
is important to ensure adequate drug therapeutic level while at the same time preventing the drug from reaching toxic level.
1821:
for sepsis is broad and has to examine (to exclude) the non-infectious conditions that may cause the systemic signs of SIRS:
1261:
and one through each vascular access device (such as an IV catheter) that has been in place more than 48 hours. Bacteria are
974:
789:
were the primary cause of sepsis before the introduction of antibiotics in the 1950s. After the introduction of antibiotics,
4622:
Septicemia... has been used... in a variety of ways... We therefore suggest that this term be eliminated from current usage.
3693:"Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis"
9055:
8123:
5252:
4585:
3858:"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study"
1469:
793:
became the predominant cause of sepsis from the 1960s to the 1980s. After the 1980s, gram-positive bacteria, most commonly
5936:"The Impact of Timing of Antibiotics on Outcomes in Severe Sepsis and Septic Shock: A Systematic Review and Meta-Analysis"
1140:, direct damage of the brain cells and disturbances of neurotransmissions causes altered mental status. Cytokines such as
9902:
9887:
9827:
2773:
2392:
2384:
2346:
2127:
1495:
1481:
1169:
1105:
1097:
1086:
1034:
762:
185:
5259:) (June 1992). "Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis".
4584:
Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. (The ACCP/SCCM Consensus Conference Committee.
1160:, leading to endothelial damage. The damaged endothelial surface inhibits anticoagulant properties as well as increases
8138:
4516:
4043:
2535:
1854:
8179:
2683:, and also the increase in the number of invasive procedures being performed, has led to an increased rate of sepsis.
10389:
10300:
9997:
9112:
8363:
8081:
5670:"Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic review"
5256:
4589:
4376:
4293:
3121:
3108:) (2011). "Ch. 146: Septic Shock". In Tintinalli JE, Stapczynski JS, Ma OJ, Cline DM, Cydulka RK, Meckler GD (eds.).
3065:
2238:
is typically not recommended. Although dopamine is useful to increase the stroke volume of the heart, it causes more
2635:
sepsis affects approximately 3 in 1,000 people, and severe sepsis contributes to more than 200,000 deaths per year.
10793:
9687:
5890:
4010:
3777:"Varying Estimates of Sepsis Mortality Using Death Certificates and Administrative Codes--United States, 1999-2014"
2898:, and then transmitted through soil or water to establish mutualistic relations with new individuals. The bacteria
2330:
2089:
1277:
997:(PRRs) of the innate immune system, which may be membrane-bound or cytosolic. There are four families of PRRs: the
951:
5204:"Point-of-care lactate testing for sepsis at presentation to health care: a systematic review of patient outcomes"
4503:
Ely EW, Goyette RE (2005). "Ch. 46: Sepsis with Acute Organ Dysfunction". In Hall JB, Schmidt GA, Wood LD (eds.).
3352:"Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality"
10143:
10002:
9935:
8976:"The diagnostic and prognostic value of systems biology research in major traumatic and thermal injury: a review"
4030:
Felner K, Smith RL (2012). "Ch. 138: Sepsis". In McKean S, Ross JJ, Dressler DD, Brotman DJ, Ginsberg JS (eds.).
2551:
1192:
765:. After three months in hospital, the patient recovered within a month and is since then fully well (as of 2023).
9495:
6804:
1041:
are not recruited to the specific site of infection, but instead they are recruited all over the body. Then, an
10274:
8436:
1730:
1702:
690:
Oxidative stress is observed in septic shock, with circulating levels of copper and vitamin C being decreased.
2707:
The term "σήψις" (sepsis) was introduced by Hippocrates in the fourth century BC, and it meant the process of
10803:
9781:
9764:
7838:
Berger MM, Oudemans-van Straaten HM (March 2015). "Vitamin C supplementation in the critically ill patient".
6800:
6122:
Zarychanski R, Abou-Setta AM, Turgeon AF, Houston BL, McIntyre L, Marshall JC, Fergusson DA (February 2013).
2088:
of beta-lactam antibiotics without exceeding total daily dose would help to keep the antibiotics level above
1343:
994:
7041:"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008"
3548:"Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012"
2369:
has a minimal effect on the cardiovascular system, it is often not recommended as a medication to help with
10798:
10788:
10670:
10382:
9758:
9080:
9043:
2890:
may not always be an accidental side effect of the deteriorating host immune system. Rather it is often an
2527:
2357:
can reduce the level of proinflammatory cytokines, altering leukocyte adhesion and proliferation, inducing
700:, which is the difference between the systolic and diastolic blood pressures. If sepsis becomes severe and
548:
5828:
1440:). Severe sepsis is an infectious disease state associated with multiple organ dysfunction syndrome (MODS)
10184:
10118:
9243:
7200:
Dell'Anna AM, Taccone FS (October 2015). "Early-goal directed therapy for septic shock: is it the end?".
2989:
2430:
2380:
2342:
2222:
2093:
1995:
1798:
1647:
the ratio of the arterial partial-pressure of oxygen to the fraction of oxygen in the gases inspired (PaO
836:
17:
6514:
Hamzaoui O, Scheeren TW, Teboul JL (August 2017). "Norepinephrine in septic shock: when and how much?".
2999:
Overall, the evidence for any role for vitamin C in the treatment of sepsis remains unclear as of 2021.
9776:
9721:
9324:
Rubin R (July 2019). "Wide Interest in a Vitamin C Drug Cocktail for Sepsis Despite Lagging Evidence".
6564:"The spectrum of cardiovascular effects of dobutamine - from healthy subjects to septic shock patients"
4957:
Nimah M, Brilli RJ (July 2003). "Coagulation dysfunction in sepsis and multiple organ system failure".
2186:
604:
540:
may be placed for access to the bloodstream and to guide treatment. Other helpful measurements include
346:
In 2017 there were 48.9 million cases and 11 million sepsis-related deaths worldwide (according to WHO)
10707:
6163:
Haase N, Perner A, Hennings LI, Siegemund M, Lauridsen B, Wetterslev M, Wetterslev J (February 2013).
1797:
level as a method to distinguish sepsis from non-infectious causes of SIRS. The same review found the
10695:
10532:
10478:
10305:
10101:
10096:
10047:
9470:
9463:
9140:"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016"
9107:
6648:"Glucocorticosteroids for sepsis: systematic review with meta-analysis and trial sequential analysis"
6297:
Holst LB, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S, et al. (October 2014).
3304:"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016"
3196:
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. (February 2016).
3008:
2857:
2772:
released during infection caused the fever and shock that were commonplace during severe infections.
2519:
2105:
1967:
1551:
1266:
1018:
9187:"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021"
9185:
Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. (November 2021).
8393:
5067:
1280:
should be measured. Lactate should be re-measured if the initial lactate was elevated. Evidence for
797:, are thought to cause more than 50% of cases of sepsis. Other commonly implicated bacteria include
563:
unless other conditions prevent such interventions. Some people might benefit from tight control of
10732:
10727:
10490:
9607:
5668:
Backes Y, van der Sluijs KF, Mackie DP, Tacke F, Koch A, Tenhunen JJ, Schultz MJ (September 2012).
5164:
4068:
Gauer RL (July 2013). "Early recognition and management of sepsis in adults: the first six hours".
2900:
2691:
2648:
2628:
2354:
2334:
2004:
2000:
1772:
1706:
1212:
693:
307:
1580:
Cardiovascular dysfunction (after fluid resuscitation with at least 40 mL/kg of crystalloid)
10199:
10042:
10027:
9710:
7603:"Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients"
2566:
are not recommended as immune supplements for a person with sepsis or septic shock. The usage of
2118:
2114:
2015:
1710:
1273:
1238:
918:, allow colonization, immune evasion, and establishment of disease in the host. Sepsis caused by
710:
533:
441:. Risk factors include being very young or old, a weakened immune system from conditions such as
177:
6999:
De Waele JJ (2009). "Source Control in the ICU". In Vincent JL, Malbrain MM, De Laet IE (eds.).
4113:
Singer P, Blaser AR, Berger MM, Alhazzani W, Calder PC, Casaer MP, et al. (February 2019).
2594:. The usage of prokinetic agents should be reassessed daily and stopped if no longer indicated.
2416:. It is one of the oldest procedures for control of infections, giving rise to the Latin phrase
1941:, and drug and fluid therapy for circulatory failure. Ensuring adequate nutrition—preferably by
962:. This forced receptor interaction induces the production of pro-inflammatory chemical signals (
10629:
10279:
10081:
9504:
8388:
8102:"Trends in Septicemia Hospitalizations and Readmissions in Selected HCUP States, 2005 and 2010"
7449:"Diagnosis and management of temperature abnormality in ICUs: a EUROBACT investigators' survey"
6019:
de Caen AR, Berg MD, Chameides L, Gooden CK, Hickey RW, Scott HF, et al. (November 2015).
5062:
3856:
Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. (January 2020).
2918:
2787:
2680:
2587:
2539:
2531:
2388:
2326:
2214:
2157:
2110:
2009:
1930:
1818:
1755:
1377:
1137:
1129:
1121:
1014:
811:
799:
790:
786:
525:
9647:
9559:
9102:
7400:"Antipyretic Therapy in Critically Ill Septic Patients: A Systematic Review and Meta-Analysis"
5847:"Surviving the first hours in sepsis: getting the basics right (an intensivist's perspective)"
4273:
3639:
Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y, et al. (December 2019).
3450:"Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis"
2962:. Evidently, not all cases of sepsis arise through such adaptive microbial strategy switches.
1971:
1288:
10742:
10581:
10284:
10205:
9555:
8073:
7970:"Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study"
7398:
Drewry AM, Ablordeppey EA, Murray ET, Stoll CR, Izadi SR, Dalton CM, et al. (May 2017).
7039:
Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. (January 2008).
5103:
4508:
4368:
4035:
3113:
2985:
2959:
2924:
2543:
2409:
2374:
2272:
1846:
1667:
1637:
653:
486:
299:
8617:
O'Brien AD, Rosenstreich DL, Scher I, Campbell GH, MacDermott RP, Formal SB (January 1980).
8347:
6073:
Lewis SR, Pritchard MW, Evans DJ, Butler AR, Alderson P, Smith AF, Roberts I (August 2018).
3546:
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. (February 2013).
2651:
in 2011, sepsis was the second most common principal reason for readmission within 30 days.
2408:
and reduce conditions favorable to microorganism growth or host defense impairment, such as
10808:
10586:
10136:
9956:
9278:
9138:
Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. (March 2017).
8928:
8711:
8619:"Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene"
8355:
8026:
7447:
Niven DJ, Laupland KB, Tabah A, Vesin A, Rello J, Koulenti D, et al. (December 2013).
6465:
4532:
Shukla P, Rao GM, Pandey G, Sharma S, Mittapelly N, Shegokar R, Mishra PR (November 2014).
3302:
Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. (March 2017).
2996:
of trials in 2021 found that the claimed benefits of the protocol could not be confirmed.
2559:
2189:
do not lower the rate of death in newborns and adults with sepsis. Evidence for the use of
2176:
is not recommended in the treatment of anemia with septic shock because it may precipitate
2133:
2019:, the addition of an antibiotic specific to the gram-negative organism is recommended. For
1979:
1950:
1946:
1195:. In those with severe sepsis and septic shock, this sequence of events leads to a type of
1145:
1132:, increased permeability of the mucosa alters the microflora, causing mucosal bleeding and
1090:
959:
895:
742:
552:
8538:
7271:
Shane AL, Stoll BJ (January 2014). "Neonatal sepsis: progress towards improved outcomes".
5202:
Morris E, McCartney D, Lasserson D, Van den Bruel A, Fisher R, Hayward G (December 2017).
8:
10737:
10665:
10591:
10522:
10179:
10086:
10007:
9897:
9892:
9882:
9835:
9752:
9736:
9596:
8915:
Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, et al. (February 2013).
8570:"High Susceptibility of Strain A Mice to Endotoxin and Endotoxin-Red Blood Cell Mixtures"
6611:
Patel GP, Balk RA (January 2012). "Systemic steroids in severe sepsis and septic shock".
2912:
2883:
2644:
2591:
2418:
2193:-enriched polyclonal preparations of IVIG is inconsistent. On the other hand, the use of
2181:
2165:
2145:
2141:
1678:
1641:
1383:
1117:
1010:
998:
770:
726:
661:
513:
9282:
8932:
8715:
8030:
7815:
7650:
Fink MP, Warren HS (October 2014). "Strategies to improve drug development for sepsis".
6469:
5165:"Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis"
2840:
costly condition billed to Medicare and the uninsured, the second-most costly billed to
2801:
was immune to the endotoxin-induced shock. The genetic locus for this effect was dubbed
2194:
2117:
is used to measure blood pressures dynamically, fluids should be administered until the
466:
289:
10555:
10228:
10059:
9992:
9909:
9870:
9845:
9770:
9601:
9436:
9411:
9392:
9349:
9216:
9167:
9002:
8975:
8951:
8916:
8869:
8844:
8820:
8795:
8776:
8648:
8542:
8414:
8328:
8303:
Geroulanos S, Douka ET (December 2006). "Historical perspective of the word "sepsis"".
8245:
8220:
8050:
7994:
7969:
7909:
7882:
7863:
7769:
7721:
7694:
7675:
7627:
7602:
7575:
7550:
7526:
7499:
7475:
7448:
7424:
7399:
7380:
7368:
7332:
7307:
7253:
7174:
7149:
7130:
7065:
7040:
6976:
6950:"Current understanding in source control management in septic shock patients: a review"
6949:
6930:
6886:
6843:
6769:
6720:
6672:
6647:
6588:
6563:
6539:
6488:
6453:
6426:
6399:
6375:
6350:
6328:
6274:
6249:
6189:
6164:
6099:
6074:
6045:
6020:
5960:
5935:
5743:
5718:
5694:
5669:
5609:
5582:
5563:
5551:
5520:
5508:
5477:
5425:
5398:
5329:
5304:
5228:
5203:
5053:
Marik PE (June 2014). "Early management of severe sepsis: concepts and controversies".
5023:
4996:
4934:
4907:
4883:
4858:
4758:
4733:
4709:
4684:
4660:
4635:
4558:
4533:
4467:
4442:
4418:
4393:
4340:
4315:
4242:
4217:
4190:
4163:
4144:
4002:
3990:
3944:
3919:
3892:
3857:
3717:
3692:
3665:
3640:
3618:
3589:"Trends in Epidemiology and Microbiology of Severe Sepsis and Septic Shock in Children"
3474:
3449:
3376:
3351:
3222:
3197:
2810:
led to the endotoxin resistant phenotype was discovered to be due to a mutation in the
2806:
2791:
2780:
at the beginning of the 20th century to denote the pyrogenic principle associated with
2563:
2523:
2405:
2337:
are not recommended to treat ARDS because it may reduce survival rates and precipitate
2259:
in sepsis is controversial. Studies do not give a clear picture as to whether and when
2073:
1834:
1826:
1822:
1696:
1596:
1369:
1254:
1200:
1021:, will up-regulate the expression of pro-inflammatory and anti-inflammatory cytokines.
927:
649:
545:
505:
498:
317:
124:
8594:
8569:
8268:
Rubin LG, Schaffner W (July 2014). "Clinical practice. Care of the asplenic patient".
5495:
Abraham E, Singer M (October 2007). "Mechanisms of sepsis-induced organ dysfunction".
5180:
4970:
4874:
3920:"Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes"
3873:
3198:"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)"
10722:
10717:
10331:
10077:
9877:
9855:
9840:
9731:
9658:
9618:
9441:
9396:
9384:
9353:
9341:
9306:
9220:
9208:
9159:
9084:
9047:
9007:
8956:
8874:
8825:
8780:
8768:
8727:
8684:
8640:
8599:
8550:
8466:
8406:
8359:
8320:
8285:
8250:
8197:
8160:
8115:
8077:
8042:
7999:
7950:
7914:
7855:
7820:
7761:
7726:
7667:
7632:
7580:
7531:
7480:
7429:
7372:
7337:
7288:
7257:
7245:
7209:
7179:
7122:
7070:
7012:
6981:
6922:
6878:
6835:
6831:
6761:
6712:
6677:
6646:
Volbeda M, Wetterslev J, Gluud C, Zijlstra JG, van der Horst IC, Keus F (July 2015).
6628:
6593:
6531:
6493:
6454:"Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis"
6431:
6400:"Early versus delayed administration of norepinephrine in patients with septic shock"
6380:
6320:
6279:
6230:
6194:
6145:
6104:
6050:
6001:
5965:
5899:
5868:
5820:
5783:
5779:
5748:
5699:
5614:
5555:
5512:
5469:
5430:
5375:
5334:
5278:
5233:
5184:
5080:
5028:
4974:
4939:
4888:
4834:
4799:
4763:
4714:
4665:
4613:
4593:
4563:
4534:"Therapeutic interventions in sepsis: current and anticipated pharmacological agents"
4512:
4472:
4423:
4372:
4345:
4289:
4247:
4195:
4136:
4077:
4039:
3994:
3970:
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. (April 2003).
3949:
3897:
3833:
3798:
3757:
3740:
Long B, Koyfman A (November 2017). "Controversies in Corticosteroid use for Sepsis".
3722:
3670:
3622:
3610:
3569:
3479:
3425:
3381:
3325:
3227:
3163:
3117:
3012:
2993:
2891:
2660:
2491:
1656:
1316:
1196:
1082:
1042:
1006:
982:
939:
879:
778:
705:
537:
517:
446:
427:
407:
280:
245:
112:
9171:
8652:
8418:
8332:
7867:
7773:
7679:
7384:
6934:
6724:
6332:
5524:
4331:
4148:
4006:
3708:
1237:
Within the first three hours of suspected sepsis, diagnostic studies should include
355:
is a potentially life-threatening condition that arises when the body's response to
10648:
10570:
10189:
9860:
9431:
9423:
9376:
9333:
9296:
9286:
9198:
9151:
8997:
8987:
8946:
8936:
8864:
8856:
8815:
8807:
8758:
8719:
8676:
8630:
8589:
8581:
8534:
8507:
8398:
8312:
8277:
8240:
8232:
8150:
8054:
8034:
7989:
7981:
7946:
7942:
7904:
7894:
7847:
7810:
7800:
7753:
7716:
7706:
7659:
7622:
7618:
7614:
7570:
7566:
7562:
7521:
7511:
7470:
7460:
7419:
7411:
7364:
7327:
7319:
7280:
7237:
7169:
7161:
7134:
7112:
7060:
7052:
7004:
6971:
6961:
6914:
6870:
6847:
6827:
6773:
6753:
6704:
6667:
6659:
6620:
6583:
6575:
6543:
6523:
6483:
6473:
6421:
6411:
6370:
6366:
6362:
6310:
6269:
6261:
6222:
6184:
6176:
6135:
6094:
6090:
6086:
6040:
6032:
5993:
5955:
5947:
5858:
5775:
5738:
5730:
5689:
5681:
5645:
5604:
5594:
5567:
5547:
5504:
5481:
5461:
5420:
5410:
5365:
5324:
5316:
5270:
5223:
5215:
5176:
5072:
5018:
5008:
4966:
4929:
4919:
4878:
4870:
4826:
4791:
4753:
4745:
4704:
4696:
4655:
4647:
4605:
4553:
4545:
4462:
4454:
4413:
4405:
4335:
4327:
4277:
4237:
4229:
4185:
4175:
4126:
3986:
3939:
3931:
3887:
3877:
3869:
3825:
3788:
3753:
3749:
3712:
3704:
3660:
3656:
3652:
3600:
3559:
3469:
3461:
3415:
3371:
3363:
3315:
3217:
3209:
3153:
2954:
2906:
2607:
those with a level of less than 2 mmol/L having a mortality of less than 15%.
2567:
2477:
2338:
2318:
2239:
2190:
1850:
1620:
1528:
1487:
1421:
1413:
1405:
1363:
1300:
1250:
1184:
1161:
1124:(ATP), can cause myocardial depression, reducing cardiac contractility and causing
990:
907:
827:
805:
633:
616:
In addition to symptoms related to the actual cause, people with sepsis may have a
438:
395:
382:. There may also be symptoms related to a specific infection, such as a cough with
379:
375:
265:
167:
147:
75:
8723:
8379:
Marshall JC (March 2008). "Sepsis: rethinking the approach to clinical research".
8180:"Conditions with the Largest Number of Adult Hospital Readmissions by Payer, 2011"
7968:
Jackson JC, Hopkins RO, Miller RR, Gordon SM, Wheeler AP, Ely EW (November 2009).
6890:
5885:
5320:
4997:"Iatrogenic salt water drowning and the hazards of a high central venous pressure"
4749:
4100:
3829:
1120:(AKI). Meanwhile, in the heart, impaired calcium transport, and low production of
10783:
10215:
10113:
9987:
9612:
9511:
9484:
9412:"Vitamin C for sepsis intervention: from redox biochemistry to clinical medicine"
9291:
9266:
9203:
9186:
9155:
9030:"National Inpatient Hospital Costs: The Most Expensive Conditions by Payer, 2013"
8860:
8585:
7985:
7851:
7415:
7165:
6874:
6757:
6527:
6478:
6036:
5951:
5261:
3691:
Fang F, Zhang Y, Tang J, Lunsford LD, Li T, Tang R, et al. (February 2019).
3564:
3547:
3158:
3141:
2968:'s "Marik protocol", also known as the "HAT" protocol, proposed a combination of
2863:
2782:
2526:
is not recommended for a person with lactic acidosis secondary to hypoperfusion.
2483:
2457:
2276:
2130:(ARDS) and sufficient tissue blood fluid, more fluids should be given carefully.
2045:
1942:
1922:
1886:
1866:
1606:
1576:
More specific definitions of end-organ dysfunction exist for SIRS in pediatrics.
1555:
1523:
Liver: disruption of protein synthetic function manifests acutely as progressive
1499:
1133:
1101:
1089:
ensues because tissues are unable to use oxygen efficiently due to inhibition of
955:
680:
580:
572:
529:
478:
10712:
9265:
Rózsa L, Apari P, Sulyok M, Tappe D, Bodó I, Hardi R, Müller V (November 2017).
9070:
9029:
8101:
7101:"Early goal-directed therapy in the treatment of severe sepsis and septic shock"
7008:
6351:"Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock"
5370:
5353:
2724:
International Statistical Classification of Diseases and Related Health Problems
2480:
does not reduce mortality in those with SIRS or sepsis and may even be harmful.
1037:
from damaged tissues. An uncontrolled immune response is then activated because
532:
may be needed to support the function of the lungs and kidneys, respectively. A
10675:
10455:
10414:
10326:
10169:
9946:
9623:
9427:
8921:
Proceedings of the National Academy of Sciences of the United States of America
8471:
7899:
7805:
7788:
7284:
7096:
6708:
6624:
6579:
6226:
6075:"Colloids versus crystalloids for fluid resuscitation in critically ill people"
5997:
5650:
5633:
4795:
4363:
Bloch KC (2009). "Ch. 4: Infectious Diseases". In McPhee SJ, Hammer GD (eds.).
4131:
4114:
2981:
2969:
2571:
2538:
devices are recommended for any person with sepsis at moderate to high risk of
2297:
2264:
2260:
2173:
2084:
1987:
1954:
1926:
1911:
1882:
1838:
1517:
1258:
1070:
1050:
875:
730:
697:
665:
560:
541:
391:
9586:
9582:
9380:
8992:
8763:
8746:
8635:
8618:
8352:
Sepsis and Non-infectious Systemic Inflammation: From Biology to Critical Care
8316:
8236:
7757:
7323:
7241:
7056:
6663:
6416:
5685:
5415:
5013:
4924:
4282:
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
4216:
Al-Khalisy H, Nikiforov I, Jhajj M, Kodali N, Cheriyath P (11 December 2015).
3465:
3320:
3303:
2786:. It was soon realized that endotoxins were expressed by most and perhaps all
10777:
10560:
10485:
10054:
10037:
9480:
5274:
5251:
Bone RC, Balk RA, et al. (The ACCP/SCCM Consensus Conference Committee.
4609:
2965:
2942:
2708:
2632:
2547:
2507:
2230:
2202:
1794:
1561:
1281:
1246:
1242:
1222:
1149:
1125:
1046:
1002:
986:
947:
935:
919:
794:
782:
750:
645:
509:
494:
470:
434:
363:
321:
221:
190:
9578:
9574:
8941:
8917:"Genomic responses in mouse models poorly mimic human inflammatory diseases"
7881:
Bauer M, Gerlach H, Vogelmann T, Preissing F, Stiefel J, Adam D (May 2020).
7601:
Martí-Carvajal AJ, Solà I, Gluud C, Lathyris D, Cardona AF (December 2012).
6966:
5100:"Synergy Between Nurses And Automation Could Be Key To Finding Sepsis Early"
4394:"Gram-positive and gram-negative bacterial toxins in sepsis: a brief review"
4233:
4180:
3605:
3588:
1053:, which is known as "compensatory anti-inflammatory response syndrome". The
10700:
10550:
10439:
10434:
10429:
10363:
10264:
10131:
10123:
10069:
9971:
9961:
9865:
9822:
9445:
9388:
9345:
9337:
9310:
9212:
9163:
9088:
9051:
9011:
8960:
8878:
8829:
8772:
8688:
8680:
8603:
8511:
8410:
8324:
8289:
8254:
8201:
8164:
8119:
8046:
8003:
7954:
7918:
7859:
7824:
7765:
7730:
7671:
7636:
7584:
7535:
7484:
7433:
7376:
7341:
7292:
7249:
7213:
7183:
7126:
7099:, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. (November 2001).
7074:
6985:
6926:
6882:
6839:
6765:
6716:
6681:
6632:
6597:
6535:
6497:
6435:
6384:
6324:
6283:
6234:
6198:
6149:
6108:
6054:
6005:
5969:
5872:
5824:
5787:
5752:
5703:
5618:
5559:
5516:
5473:
5434:
5379:
5338:
5237:
5188:
5084:
5032:
4978:
4943:
4892:
4838:
4803:
4767:
4718:
4669:
4567:
4476:
4427:
4349:
4251:
4199:
4140:
4081:
3998:
3953:
3901:
3837:
3802:
3793:
3776:
3761:
3726:
3674:
3614:
3573:
3483:
3429:
3385:
3367:
3329:
3231:
3213:
3167:
3053:
2668:
2579:
2555:
2362:
2314:
2288:
2284:
2069:
2049:
1938:
1750:≥ 2 times the upper limit of normal for age or 2-fold increase in baseline
1600:
1524:
1444:
1180:
1176:
970:
891:
857:
754:
684:
556:
520:
is not enough to maintain blood pressure, then the use of medications that
461:(SIRS) criteria in the setting of presumed infection. In 2016, a shortened
450:
423:
325:
303:
250:
200:
31:
9679:
8731:
8644:
8554:
8281:
7551:"N-acetylcysteine for sepsis and systemic inflammatory response in adults"
6918:
6315:
6299:"Lower versus higher hemoglobin threshold for transfusion in septic shock"
6298:
6140:
6123:
5934:
Sterling SA, Miller WR, Pryor J, Puskarich MA, Jones AE (September 2015).
5282:
5219:
5076:
4617:
4316:"Sepsis and Septic Shock: Current Treatment Strategies and New Approaches"
3972:"2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference"
3420:
3403:
969:
There are a number of microbial factors that may cause the typical septic
696:
falls during the early stages of sepsis, causing a widening/increasing of
10687:
10596:
10509:
10473:
10463:
10405:
10346:
10269:
9850:
9642:
8811:
8155:
7117:
7100:
5863:
5846:
4443:"Invasive candidiasis as a cause of sepsis in the critically ill patient"
4095:
2948:
2936:
2823:
2741:
are present in the blood at abnormal levels and are the causative issue,
2631:
worldwide of sepsis is estimated to be 18 million cases per year. In the
2583:
2575:
2438:
2422:, and remains important despite the emergence of more modern treatments.
2218:
2201:
is also not useful. Meanwhile, the blood purification technique (such as
2065:
2053:
2031:
1842:
1802:
therapy for improved antibiotic stewardship and better patient outcomes.
1675:
1586:
1449:
1395:
Sepsis Steps. Training tool for teaching the progression of sepsis stages
1292:
1284:
lactate measurement over usual methods of measurement, however, is poor.
1188:
1157:
1153:
1066:
851:
746:
738:
701:
676:
657:
629:
621:
584:
564:
521:
490:
482:
473:
before starting antibiotics; however, the diagnosis does not require the
415:
411:
399:
371:
229:
142:
137:
8546:
8402:
8139:"The epidemiology of sepsis in the United States from 1979 through 2000"
7711:
5909:
4651:
3971:
3882:
2283:. Treatment with corticosteroids might be most beneficial in those with
10657:
10624:
10606:
10504:
10353:
10336:
10248:
10164:
10108:
9914:
9653:
9301:
8038:
7695:"Blood glucose control in patients with severe sepsis and septic shock"
5734:
4700:
4458:
4409:
2930:
2895:
2887:
2819:
2734:
2640:
2494:) was originally introduced for severe sepsis (as identified by a high
2370:
2263:
should be used. The 2016 Surviving Sepsis Campaign recommends low dose
2243:
2177:
2161:
2057:
2036:
2027:
2003:
organisms. In case of people having a high risk of being infected with
1975:
1918:
1907:
1874:
1870:
1857:(HLH) may have similar symptoms and are on the differential diagnosis.
1751:
1747:
1461:
1409:
1353:
1265:
in only about 30% of cases. Another possible method of detection is by
1262:
1165:
1058:
922:
bacteria is thought to be largely due to a response by the host to the
911:
887:
841:
817:
474:
462:
457:. Previously, a sepsis diagnosis required the presence of at least two
54:
10374:
9538:
9517:
8845:"Physiologically relevant human tissue models for infectious diseases"
6265:
4830:
4549:
3935:
2733:
The current terms are dependent on the microorganism that is present:
10514:
10499:
10341:
10223:
10159:
8437:"Understand How ICD-10 Expands Sepsis Coding – AAPC Knowledge Center"
6788:
6398:
Bai X, Yu W, Ji W, Lin Z, Tan S, Duan K, et al. (October 2014).
6180:
5465:
5201:
4164:"Pediatric Sepsis Guidelines: Summary for resource-limited countries"
2973:
2811:
2777:
2765:
2611:
2495:
2487:
2366:
2358:
2292:
2287:
and early severe ARDS, whereas its role in others such as those with
2169:
2041:
1983:
1878:
1793:
concluded moderate-quality evidence exists to support the use of the
1766:
1565:
1536:
1532:
1417:
1304:
1226:
1141:
1109:
1062:
1054:
1038:
978:
963:
931:
625:
575:
is controversial, with some reviews finding benefit, and others not.
383:
356:
332:
8616:
7663:
7516:
7465:
2878:
Phenotypic strategy switches of microbes capable of provoking sepsis
2144:
in terms of risk of death. Starches also carry an increased risk of
1218:
10758:
10634:
10468:
10243:
10194:
10174:
10032:
9951:
9726:
9667:
8225:
European Journal of Clinical Microbiology & Infectious Diseases
6349:
Alejandria MM, Lansang MA, Dans LF, Mantaring JB (September 2013).
6121:
5599:
4285:
3818:
Best Practice & Research. Clinical Obstetrics & Gynaecology
3195:
2977:
2841:
2761:
2750:
2738:
2712:
2664:
2500:
2301:
2256:
2235:
2123:
2061:
1897:
1720:
1569:
1543:
1437:
1308:
1113:
1057:(cell death) of lymphocytes further worsens the immunosuppression.
943:
915:
822:
652:(which may be accompanied by a faster breathing rate that leads to
641:
419:
152:
6211:
4816:
4734:"Recognition of Staphylococcus aureus by the innate immune system"
4115:"ESPEN guideline on clinical nutrition in the intensive care unit"
10358:
10238:
2746:
2742:
2610:
There are a number of prognostic stratification systems, such as
2511:
2413:
2361:(cell death) of the lymphocytes, possibly with a toxic effect on
2137:
1312:
1230:
1030:
923:
846:
774:
734:
568:
387:
9468:
Knowledge's health care articles can be viewed offline with the
6452:
Avni T, Lador A, Lev S, Leibovici L, Paul M, Grossman A (2015).
5765:
5162:
1348:<36 °C (96.8 °F) or >38 °C (100.4 °F)
938:
bacteria may result from an immunological response to cell wall
426:
is low blood pressure due to sepsis that does not improve after
213:
May be rapid (less than three hours) or prolonged (several days)
9569:
9550:
9499:
9235:
8219:
Koh GC, Peacock SJ, van der Poll T, Wiersinga WJ (April 2012).
8218:
7600:
7500:"Clinical review: fever in septic ICU patients--friend or foe?"
7226:
5667:
4780:
3815:
3638:
2769:
2754:
2727:
2700:
2656:
2387:, as a growing body of evidence points to reduced durations of
2213:
If the person has been sufficiently fluid resuscitated but the
1790:
1547:
1404:
SIRS is the presence of two or more of the following: abnormal
1391:
1382:<4x10/L (<4000/mm), >12x10/L (>12,000/mm), or ≥10%
1296:
1078:
758:
442:
362:
This initial stage of sepsis is followed by suppression of the
255:
240:
157:
8524:
7880:
6645:
6348:
5982:
4215:
1966:
these sites are suspected. In severe sepsis and septic shock,
1949:—is important during prolonged illness. Medication to prevent
1568:
that depress myocyte function, cellular damage, manifest as a
9184:
7497:
7308:"Neonatal infectious diseases: evaluation of neonatal sepsis"
7305:
6296:
4636:"Recognition of lipopolysaccharide pattern by TLR4 complexes"
2874:
2798:
2404:
Source control refers to physical interventions to control a
1806:
1465:
1164:, which may lead to intravascular clotting, the formation of
832:
729:
of a German hospital (2015) with a severe sepsis caused by a
637:
617:
403:
367:
132:
7397:
7354:
6947:
6162:
5933:
5163:
Wacker C, Prkno A, Brunkhorst FM, Schlattmann P (May 2013).
4161:
3641:"Corticosteroids for treating sepsis in children and adults"
3110:
Tintinalli's Emergency Medicine: A Comprehensive Study Guide
2882:
Some authors suggest that initiating sepsis by the normally
2760:
By the end of the 19th century, it was widely believed that
2383:
are not suggested for use in sepsis cases in the absence of
1762:
Liver dysfunction (only applicable to infants > 1 month)
1727:
or 50% drop from maximum in chronically thrombocytopenic, or
1456:
In 2016 a new consensus was reached to replace screening by
1215:
to bring attention to potential cases as early as possible.
1108:(ARDS). Impaired utilization of oxygen in the liver impairs
10233:
9919:
7837:
4112:
3855:
2672:
2077:
1934:
1830:
977:(PAMPs). Examples of PAMPs include lipopolysaccharides and
883:
733:
of incidental negative events after a prior surgery of the
454:
270:
260:
195:
162:
84:
10311:
European Society of Paediatric and Neonatal Intensive Care
7967:
7931:
7094:
6613:
American Journal of Respiratory and Critical Care Medicine
6018:
5986:
American Journal of Respiratory and Critical Care Medicine
4784:
American Journal of Respiratory and Critical Care Medicine
8914:
7548:
6948:
Lagunes L, Encina B, Ramirez-Estrada S (September 2016).
6817:
6742:
6072:
5450:
5399:"qSOFA does not replace SIRS in the definition of sepsis"
5107:
4908:"Organ dysfunction as a new standard for defining sepsis"
4863:
Cardiovascular & Hematological Disorders Drug Targets
3545:
2716:
2136:
is recommended as the fluid of choice for resuscitation.
1400:
and septic shock. The definition of SIRS is shown below:
1299:(free air on an abdominal X-ray or CT scan), an abnormal
1074:
950:
also may cause sepsis. Superantigens simultaneously bind
93:
9137:
8177:
7306:
Camacho-Gonzalez A, Spearman PW, Stoll BJ (April 2013).
3774:
3301:
2715:
used the term "blood rot" for diseases linked to severe
1531:
and disruption of metabolic functions leads to impaired
1430:
is defined as SIRS in response to an infectious process.
898:. However, sepsis also causes similar response to SIRS.
398:
may have no symptoms of a specific infection, and their
7446:
7150:"Lactate as a hemodynamic marker in the critically ill"
7038:
5537:
4314:
Polat G, Ugan RA, Cadirci E, Halici Z (February 2017).
3969:
2550:
are useful in a person with risk factors of developing
2060:, is chosen for people with severe sepsis, followed by
8221:"The impact of diabetes on the pathogenesis of sepsis"
8136:
7549:
Szakmany T, Hauser B, Radermacher P (September 2012).
6786:
6513:
6247:
5250:
4583:
4313:
2126:
are added until the ScvO2 is optimized. In those with
1705:
with drop in GCS of 3 or more points in a person with
9942:
Critical illness–related corticosteroid insufficiency
9264:
9071:"Costs for Hospital Stays in the United States, 2011"
8793:
8701:
8665:
8348:"Ch. 1: Definition of Sepsis and Non-infectious SIRS"
8137:
Martin GS, Mannino DM, Eaton S, Moss M (April 2003).
7743:
6451:
4859:"Sepsis pathophysiology and anesthetic consideration"
4531:
3775:
Epstein L, Dantes R, Magill S, Fiore A (April 2016).
3690:
2281:
critical illness–related corticosteroid insufficiency
1807:
soluble urokinase-type plasminogen activator receptor
1535:
metabolism, resulting in elevated unconjugated serum
1460:(SIRS) with the sequential organ failure assessment (
96:
90:
81:
9528:
8973:
8095:
8093:
7498:
Launey Y, Nesseler N, Mallédant Y, Seguin P (2011).
7199:
6248:
Patel A, Laffan MA, Waheed U, Brett SJ (July 2014).
2391:, ICU and hospital stays. However, paralytic use in
757:
via the machine on the left became necessary due to
87:
9068:
8747:"[Mouse Models of Sepsis and Septic Shock]"
8339:
8016:
7787:Liang B, Su J, Shao H, Chen H, Xie B (March 2023).
7692:
6561:
3586:
3349:
2980:as a treatment for preventing sepsis for people in
2797:It was discovered in 1965 that a strain of C3H/HeJ
1917:Apart from the timely administration of fluids and
1684:
supplemental oxygen requirement of greater than FiO
1452:, despite the administration of intravenous fluids.
78:
8794:Lewis AJ, Seymour CW, Rosengart MR (August 2016).
5887:Scottish Intercollegiate Guidelines Network (SIGN)
5354:"New Sepsis Criteria: A Change We Should Not Make"
2856:A large international collaboration entitled the "
1572:leak (although not necessarily ischemic in nature)
839:. The most common causes for parasitic sepsis are
551:. People with sepsis need preventive measures for
8090:
7001:Yearbook of Intensive Care and Emergency Medicine
6860:
6344:
6342:
5396:
5048:
5046:
5044:
5042:
4271:
3401:
2373:in this situation due to concerns it may lead to
1662:arterial partial-pressure of carbon dioxide (PaCO
1609:: serum lactate 2 times the upper limit of normal
648:. Signs of established sepsis include confusion,
10775:
9069:Pfuntner A, Wier LM, Steiner C (December 2013).
8178:Hines AL, Barrett ML, et al. (April 2014).
7693:Hirasawa H, Oda S, Nakamura M (September 2009).
5580:
4810:
4731:
4579:
4577:
4440:
4385:
4274:"Ch. 75: Sepsis, Severe Sepsis and Septic Shock"
3587:Sehgal M, Ladd HJ, Totapally B (December 2020).
3139:
3135:
3133:
2317:of 6 mL/kg of predicted body weight (PBW) and a
2048:is chosen. If fungal infection is suspected, an
1233:, and yellow cap for blood samples from children
9227:
8302:
8296:
7786:
7147:
7034:
7032:
7030:
7028:
7003:. Springer Berlin Heidelberg. pp. 93–101.
6738:
6736:
6734:
6509:
6507:
6115:
4498:
4496:
4494:
4492:
4490:
4488:
4486:
4025:
4023:
3965:
3963:
3191:
3189:
3187:
3185:
3183:
3181:
3179:
3177:
402:may be low or normal instead of constituting a
191:temporary, transient, or permanent organ damage
9366:
8967:
8695:
8267:
8099:
7925:
6694:
6339:
5806:"Neonatal sepsis: a continuing disease burden"
5716:
5039:
4267:
4265:
4263:
4261:
4063:
4061:
4059:
4057:
4055:
3443:
3441:
3439:
2425:
989:of the gram-positive bacterial cell wall, and
10390:
9695:
9062:
9023:
9021:
8908:
8659:
8518:
8372:
7874:
7686:
6903:
5759:
5663:
5661:
5494:
5158:
5156:
5154:
4899:
4774:
4685:"Anti-endotoxin vaccines: back to the future"
4574:
4211:
4209:
3913:
3911:
3130:
2958:spp. are all capable of such a high level of
1636:Respiratory dysfunction (in the absence of a
1512:pediatric acute respiratory distress syndrome
359:causes injury to its own tissues and organs.
62:Skin blotching and inflammation due to sepsis
8567:
8561:
8061:
7961:
7542:
7348:
7025:
6731:
6557:
6555:
6553:
6504:
5927:
5799:
5797:
5531:
5488:
5444:
5397:Vincent JL, Martin GS, Levy MM (July 2016).
5298:
5296:
5294:
5292:
4990:
4988:
4856:
4725:
4483:
4434:
4391:
4032:Principles and Practice of Hospital Medicine
4020:
3960:
3350:Jawad I, Lukšić I, Rafnsson SB (June 2012).
3297:
3295:
3293:
3291:
3289:
3287:
3285:
3283:
3281:
3279:
3277:
3275:
3273:
3271:
3269:
3267:
3265:
3263:
3261:
3174:
3142:"Sepsis: current dogma and new perspectives"
2711:of organic matter. In the eleventh century,
1257:are necessary. At least one should be drawn
1085:are more apoptosis resistant. Subsequently,
973:. An invading pathogen is recognized by its
9709:
9233:
9095:
8885:
8610:
8130:
7607:The Cochrane Database of Systematic Reviews
7555:The Cochrane Database of Systematic Reviews
7299:
7220:
7195:
7193:
6811:
6639:
6447:
6445:
6355:The Cochrane Database of Systematic Reviews
6079:The Cochrane Database of Systematic Reviews
6012:
5976:
5838:
5717:Mayr FB, Yende S, Angus DC (January 2014).
5390:
5345:
5244:
4956:
4258:
4052:
4029:
3781:MMWR. Morbidity and Mortality Weekly Report
3739:
3686:
3684:
3645:The Cochrane Database of Systematic Reviews
3541:
3539:
3537:
3535:
3533:
3531:
3529:
3527:
3525:
3523:
3521:
3519:
3517:
3515:
3513:
3436:
3345:
3343:
3341:
3339:
3259:
3257:
3255:
3253:
3251:
3249:
3247:
3245:
3243:
3241:
1319:may indicate the presence of an infection.
1289:inflammation of the abdominal cavity lining
878:) may be followed by a prolonged period of
10397:
10383:
9702:
9688:
9258:
9040:Agency for Healthcare Research and Quality
9027:
9018:
8842:
8836:
8787:
8489:
8261:
8194:United States National Library of Medicine
8190:Agency for Healthcare Research and Quality
8171:
8112:United States National Library of Medicine
8070:Harrison's Principles of Internal Medicine
8019:Annals of the New York Academy of Sciences
7780:
7649:
7596:
7594:
7491:
7391:
7270:
7141:
6697:The American Journal of Emergency Medicine
6397:
6068:
6066:
6064:
5658:
5195:
5151:
4525:
4502:
4206:
3908:
3634:
3632:
3511:
3509:
3507:
3505:
3503:
3501:
3499:
3497:
3495:
3493:
3397:
3395:
3099:
3097:
3095:
3093:
3091:
3089:
3087:
3085:
3083:
3062:Centers for Disease Control and Prevention
3048:
3046:
3044:
3042:
3040:
3038:
3036:
3034:
3032:
3030:
2764:produced substances that could injure the
2156:The Surviving Sepsis Campaign recommended
1626:core to peripheral temperature difference
880:decreased functioning of the immune system
737:. After an emergency surgery, he received
640:. Early signs include a rapid heart rate,
53:
9435:
9300:
9290:
9202:
9001:
8991:
8950:
8940:
8868:
8819:
8762:
8634:
8593:
8392:
8244:
8154:
8010:
7993:
7908:
7898:
7814:
7804:
7720:
7710:
7626:
7574:
7525:
7515:
7474:
7464:
7440:
7423:
7331:
7264:
7173:
7116:
7064:
6975:
6965:
6797:National Heart, Lung, and Blood Institute
6671:
6610:
6604:
6587:
6550:
6487:
6477:
6425:
6415:
6374:
6314:
6290:
6273:
6241:
6205:
6188:
6156:
6139:
6098:
6044:
5959:
5862:
5851:The Journal of Antimicrobial Chemotherapy
5803:
5794:
5742:
5693:
5649:
5608:
5598:
5424:
5414:
5369:
5328:
5302:
5289:
5227:
5066:
5022:
5012:
4985:
4950:
4933:
4923:
4905:
4882:
4757:
4708:
4676:
4659:
4557:
4466:
4417:
4339:
4241:
4189:
4179:
4155:
4130:
3943:
3891:
3881:
3792:
3716:
3664:
3604:
3563:
3473:
3447:
3419:
3375:
3319:
3221:
3157:
3015:and severe acute sepsis after a dog bite)
2730:, such as "Sepsis due to streptococcus".
1812:
1775:(ALT) ≥ 2 times the upper limit of normal
1295:, or an intestinal infarction. A pierced
769:Infections leading to sepsis are usually
504:Sepsis requires immediate treatment with
463:sequential organ failure assessment score
394:. The very young, old, and people with a
8974:Hazeldine J, Hampson P, Lord JM (2016).
8499:Journal of the National Cancer Institute
8430:
8428:
8378:
8350:. In Cavaillon JM, Christophe A (eds.).
8212:
8100:Sutton JP, Friedman B (September 2013).
7643:
7190:
6998:
6854:
6442:
5710:
5631:
4627:
4309:
4307:
4305:
3733:
3681:
3402:Angus DC, van der Poll T (August 2013).
3336:
3238:
3106:American College of Emergency Physicians
2873:
2690:
2329:due to sepsis-induced severe ARDS. High
1896:
1475:
1390:
1217:
720:
589:
10404:
9505:SIRS, Sepsis, and Septic Shock Criteria
9076:Healthcare Cost and Utilization Project
9035:Healthcare Cost and Utilization Project
8744:
8434:
8345:
8185:Healthcare Cost and Utilization Project
8107:Healthcare Cost and Utilization Project
8067:
7591:
7090:
7088:
7086:
7084:
6780:
6568:Revista Brasileira de Terapia Intensiva
6061:
5879:
5844:
5768:Critical Reviews in Oncology/Hematology
5351:
5208:The British Journal of General Practice
4852:
4850:
4848:
4633:
4441:Delaloye J, Calandra T (January 2014).
4356:
4016:from the original on 24 September 2015.
3924:Expert Review of Anti-Infective Therapy
3629:
3490:
3392:
3140:Deutschman CS, Tracey KJ (April 2014).
3080:
3027:
2844:, and the fourth-most costly billed to
2534:(UFH), and mechanical prophylaxis with
2515:recommended for blood glucose testing.
2325:O is recommended for those who require
1974:with broad coverage, or broad-spectrum
1688:0.5 to maintain oxygen saturation ≥ 92%
1458:systemic inflammatory response syndrome
1329:Systemic inflammatory response syndrome
1049:1 (TH1) is shifted to TH2, mediated by
459:systemic inflammatory response syndrome
286:Systemic inflammatory response syndrome
14:
10776:
9058:from the original on 6 September 2017.
8891:
8568:Heppner G, Weiss DW (September 1965).
8454:
8126:from the original on 6 September 2017.
6897:
6688:
6562:Dubin A, Lattanzio B, Gatti L (2017).
6213:and meta-analysis of the literature".
5097:
3917:
2829:
2247:abnormally increasing the heart rate.
2199:disseminated intravascular coagulation
1853:. Hyperinflammatory syndromes such as
1737:Disseminated intravascular coagulation
1045:state ensues when the proinflammatory
975:pathogen-associated molecular patterns
27:Life-threatening response to infection
10378:
9683:
9409:
9323:
9317:
9246:from the original on 8 September 2015
9028:Torio CM, Moore BJ (1 January 2006).
8669:Blood Cells, Molecules & Diseases
8495:
8467:The Merck Manual—Home Health Handbook
8425:
7148:Fuller BM, Dellinger RP (June 2012).
6807:from the original on 3 December 2019.
5114:from the original on 27 February 2018
5052:
4994:
4857:Yuki K, Murakami N (6 January 2016).
4732:Fournier B, Philpott DJ (July 2005).
4682:
4640:Experimental & Molecular Medicine
4362:
4302:
4088:
4067:
3851:
3849:
3847:
2099:
611:
512:. Ongoing care often continues in an
261:Chronic Obstructive Pulmonary Disease
10190:Recombinant activated protein C
9524:. U.S. National Library of Medicine.
8843:Mills M, Estes MK (September 2016).
7081:
5253:American College of Chest Physicians
4845:
4586:American College of Chest Physicians
4222:J Community Hosp Intern Med Perspect
3448:Cao C, Yu M, Chai Y (October 2019).
3068:from the original on 4 December 2014
2271:During critical illness, a state of
1873:in the first month of life, such as
1805:A 2012 systematic review found that
1470:American College of Chest Physicians
1035:damage-associated molecular patterns
993:. These PAMPs are recognized by the
901:
366:. Common signs and symptoms include
196:extra corporeal membrane oxygenation
9903:Multiple organ dysfunction syndrome
9888:Acute respiratory distress syndrome
9828:Multiple organ dysfunction syndrome
9416:Molecular and Cellular Biochemistry
8539:10.1093/infdis/128.Supplement_1.S17
8270:The New England Journal of Medicine
8143:The New England Journal of Medicine
7105:The New England Journal of Medicine
6303:The New England Journal of Medicine
5305:"Sepsis: recognition and treatment"
5091:
3408:The New England Journal of Medicine
3103:
2522:may be used if indicated. However,
2347:continuous positive airway pressure
2164:levels below 70 g/L if there is no
2128:acute respiratory distress syndrome
1496:acute respiratory distress syndrome
1482:Multiple organ dysfunction syndrome
1448:is severe sepsis plus persistently
1106:acute respiratory distress syndrome
1098:multiple organ dysfunction syndrome
763:multiple organ dysfunction syndrome
186:Multiple organ dysfunction syndrome
24:
9267:"The evolutionary logic of sepsis"
8904:from the original on 9 April 2017.
8527:The Journal of Infectious Diseases
8208:from the original on 4 March 2016.
7369:10.1097/01.PCC.0000074266.10576.9B
7312:Pediatric Clinics of North America
5898:. Guideline 139. Edinburgh: SIGN.
5804:Satar M, Ozlü F (September 2012).
5552:10.1097/01.PCC.0000149131.72248.E6
5509:10.1097/01.CCM.0000282072.56245.91
4272:Munford RS, Suffredini AF (2014).
3991:10.1097/01.CCM.0000050454.01978.3B
3844:
2536:intermittent pneumatic compression
2268:benefit, as did two 2019 reviews.
2217:is not greater than 65 mmHg,
1860:
1855:hemophagocytic lymphohistiocytosis
1527:due to an inability to synthesize
868:
749:via automated injection employing
158:absent or near absent urine output
25:
10820:
10301:Society of Critical Care Medicine
9998:Ventilator-associated lung injury
9456:
9271:Infection, Genetics and Evolution
9119:from the original on 4 March 2014
9113:Society of Critical Care Medicine
8796:"Current Murine Models of Sepsis"
8477:from the original on 28 July 2017
7935:The Journal of Emergency Medicine
7699:World Journal of Gastroenterology
5813:The Turkish Journal of Pediatrics
5634:"PCT testing in sepsis protocols"
5257:Society of Critical Care Medicine
5139:. WVUH Laboratories. 7 April 2012
4875:10.2174/1871529x15666150108114810
4634:Park BS, Lee JO (December 2013).
4590:Society of Critical Care Medicine
3742:The Journal of Emergency Medicine
2399:
2187:intravenous immunoglobulin (IVIG)
2151:
1183:, a deficiency of chemicals that
9817:
9462:
9403:
9360:
9178:
9131:
8738:
7831:
7737:
7357:Pediatric Critical Care Medicine
7154:Current Opinion in Critical Care
6954:Annals of Translational Medicine
6832:10.1002/j.1875-9114.2012.01027.x
6516:Current Opinion in Critical Care
5780:10.1016/j.critrevonc.2017.03.023
5581:Pierrakos C, Vincent JL (2010).
5540:Pediatric Critical Care Medicine
4320:The Eurasian Journal of Medicine
3404:"Severe sepsis and septic shock"
2331:positive end expiratory pressure
2279:may occur. This has been termed
2090:minimum inhibitory concentration
1372:<32 mmHg (4.3 kPa)
1278:central venous oxygen saturation
1193:ATP-sensitive potassium channels
952:major histocompatibility complex
683:and is part of the criteria for
74:
10003:Ventilator-associated pneumonia
9936:Critical illness polyneuropathy
7230:Internal and Emergency Medicine
6992:
6941:
6787:NHLBI–NIH ARDS Network (2014).
6391:
5719:"Epidemiology of severe sepsis"
5638:Frontiers in Analytical Science
5625:
5574:
5169:The Lancet. Infectious Diseases
5126:
4906:Fujishima S (1 November 2016).
4538:British Journal of Pharmacology
4392:Ramachandran G (January 2014).
4332:10.5152/eurasianjmed.2017.17062
4106:
3809:
3768:
3709:10.1001/jamainternmed.2018.5849
3580:
2699:, carrying a spray can marked "
2622:
2552:upper gastrointestinal bleeding
2542:. Stress ulcer prevention with
2335:β2 adrenergic receptor agonists
2208:
1910:", is in widespread use in the
1592:two of the following criteria:
1464:) and the abbreviated version (
1307:(with focal opacification), or
1081:all undergo apoptosis, whereas
1024:
410:or blood flow. The presence of
9410:Li YR, Zhu H (December 2021).
8745:Korneev KV (18 October 2019).
7947:10.1016/j.jemermed.2009.03.016
7840:Curr Opin Clin Nutr Metab Care
7652:Nature Reviews. Drug Discovery
7619:10.1002/14651858.CD004388.pub6
7567:10.1002/14651858.CD006616.pub2
6367:10.1002/14651858.CD001090.pub2
6091:10.1002/14651858.CD000567.pub7
5892:Care of Deteriorating Patients
4284:(8th ed.). Philadelphia:
3754:10.1016/j.jemermed.2017.05.024
3657:10.1002/14651858.CD002243.pub4
3054:"Sepsis Questions and Answers"
1960:
1901:Intravenous fluids being given
1731:international normalized ratio
1655:) < 300 (the definition of
1560:Heart: systolic and diastolic
1510:< 300), different ratio in
1322:
13:
1:
9782:Geriatric intensive-care unit
9765:Pediatric intensive care unit
8892:Engber D (13 February 2013).
8724:10.1126/science.282.5396.2085
6801:National Institutes of Health
5583:"Sepsis biomarkers: a review"
5321:10.7861/clinmedicine.12-3-276
5303:Soong J, Soni N (June 2012).
5181:10.1016/S1473-3099(12)70323-7
5098:Harris R (22 February 2018).
4971:10.1016/s0749-0704(03)00008-3
4912:Inflammation and Regeneration
4750:10.1128/CMR.18.3.521-540.2005
4738:Clinical Microbiology Reviews
4103:. Retrieved 29 November 2014.
3874:10.1016/S0140-6736(19)32989-7
3830:10.1016/j.bpobgyn.2016.05.008
3020:
2681:immunosuppressive medications
2308:
1892:
1784:
1096:Inflammatory responses cause
995:pattern recognition receptors
422:may suggest poor blood flow.
10185:Neuromuscular-blocking drugs
10128:Nutritional supplementation
9759:Neonatal intensive care unit
9292:10.1016/j.meegid.2017.09.006
9204:10.1097/CCM.0000000000005337
9156:10.1097/CCM.0000000000002255
9081:National Library of Medicine
9044:National Library of Medicine
8861:10.1016/j.drudis.2016.06.020
8586:10.1128/JB.90.3.696-703.1965
8381:Journal of Leukocyte Biology
7986:10.1097/SMJ.0b013e3181b6a592
7852:10.1097/MCO.0000000000000148
7416:10.1097/CCM.0000000000002285
7166:10.1097/MCC.0b013e3283532b8a
6875:10.1097/CCM.0b013e31825fec26
6758:10.1097/CCM.0b013e31817603ba
6528:10.1097/mcc.0000000000000418
6479:10.1371/journal.pone.0129305
6037:10.1161/cir.0000000000000266
5952:10.1097/CCM.0000000000001142
3565:10.1097/CCM.0b013e31827e83af
3159:10.1016/j.immuni.2014.04.001
2886:(or neutral) members of the
2851:
2834:
2601:
2528:Low-molecular-weight heparin
2503:also has not shown benefit.
2080:unless sepsis is suspected.
1937:dysfunction, transfusion of
1525:disruption of blood clotting
1206:
1168:in small blood vessels, and
1029:Upon detection of microbial
201:blood filtration or dialysis
7:
10285:Water-electrolyte imbalance
10119:Early goal-directed therapy
8072:(18th ed.). New York:
7009:10.1007/978-3-540-92276-6_9
5454:Annals of Internal Medicine
5371:10.1016/j.chest.2016.02.653
4505:Principles of Critical Care
3011:(Bacteria that can lead to
3002:
2990:science by press conference
2869:
2586:and consequently provoke a
2518:Intermittent or continuous
2452:
2431:Early goal directed therapy
2426:Early goal directed therapy
2343:spontaneous breathing trial
2250:
2094:therapeutic drug monitoring
981:in gram-negative bacteria,
837:hospital-acquired infection
670:disorders in blood-clotting
465:(SOFA score), known as the
10:
10825:
10137:Total parenteral nutrition
10070:Life-supporting treatments
9777:Critical illness insurance
9428:10.1007/s11010-021-04240-z
9079:. Statistical Brief #168.
9038:. Statistical Brief #204.
8435:Stewart C (8 April 2011).
8188:. Statistical Brief #172.
8110:. Statistical Brief #161.
7900:10.1186/s13054-020-02950-2
7806:10.1186/s13054-023-04392-y
7746:Nutrition Research Reviews
7285:10.1016/j.jinf.2013.09.011
6709:10.1016/j.ajem.2018.11.040
6625:10.1164/rccm.201011-1897CI
6580:10.5935/0103-507x.20170068
6227:10.1016/j.jcrc.2013.09.031
5998:10.1164/rccm.201601-0024oc
5651:10.3389/frans.2023.1229003
5134:"Blood Culture Collection"
4796:10.1164/rccm.201301-0036CP
4507:(3rd ed.). New York:
4367:(6th ed.). New York:
4365:Pathophysiology of Disease
4276:. In Bennett JE, Dolin R,
4132:10.1016/j.clnu.2018.08.037
3112:(7th ed.). New York:
2988:, leading to criticism of
2686:
1968:broad-spectrum antibiotics
1865:In common clinical usage,
1479:
1293:infection of the bile duct
1158:cells lining blood vessels
890:, or the initial state in
660:due to decreased systemic
516:. If an adequate trial of
29:
10751:
10696:Hypersegmented neutrophil
10686:
10656:
10647:
10617:
10603:Hemoglobin precipitation
10569:
10543:
10533:Hereditary stomatocytosis
10479:Hereditary elliptocytosis
10448:
10422:
10413:
10319:
10306:Surviving Sepsis Campaign
10293:
10257:
10214:
10152:
10102:Ventricular assist device
10097:Intra-aortic balloon pump
10068:
10048:Pulmonary artery catheter
10020:
9970:
9928:
9797:
9790:
9745:
9717:
9633:
9532:
9381:10.1177/02601060211018371
9108:Surviving Sepsis Campaign
8993:10.1186/s41038-016-0059-3
8764:10.1134/S0026893319050108
8636:10.4049/jimmunol.124.1.20
8317:10.1007/s00134-006-0392-2
8237:10.1007/s10096-011-1337-4
7758:10.1017/S0954422418000124
7324:10.1016/j.pcl.2012.12.003
7242:10.1007/s11739-015-1248-y
7057:10.1007/s00134-007-0934-2
6664:10.1007/s00134-015-3899-6
6417:10.1186/s13054-014-0532-y
6031:(18 Suppl 2): S526–S542.
5686:10.1007/s00134-012-2613-1
5416:10.1186/s13054-016-1389-z
5014:10.1186/s13613-014-0021-0
4925:10.1186/s41232-016-0029-y
4683:Cross AS (January 2014).
4070:American Family Physician
3466:10.1038/s41419-019-2015-1
3321:10.1007/s00134-017-4683-6
3009:Capnocytophaga canimorsus
2858:Surviving Sepsis Campaign
2520:renal replacement therapy
2441:may be equivalent to ScvO
2275:and tissue resistance to
2106:Surviving Sepsis Campaign
1552:electrolyte abnormalities
1267:polymerase chain reaction
1213:electronic health records
704:compromise advances, the
679:seen in sepsis can cause
342:
331:
313:
295:
279:
228:
224:triggered by an infection
217:
209:
176:
123:
111:
66:
61:
52:
47:
10728:Critical green inclusion
10519:Sickle cell/drepanocyte
10491:Hereditary spherocytosis
9510:17 February 2015 at the
8751:Molekuliarnaia Biologiia
7974:Southern Medical Journal
7273:The Journal of Infection
6215:Journal of Critical Care
5845:Daniels R (April 2011).
5632:Valencia L (July 2023).
5275:10.1378/chest.101.6.1644
5001:Annals of Intensive Care
4610:10.1378/chest.101.6.1644
4286:Elsevier Health Sciences
4096:MedlinePlus Encyclopedia
3454:Cell Death & Disease
3356:Journal of Global Health
2901:Streptococcus pneumoniae
2464:
2355:Inhalational anesthetics
2298:ACTH stimulation testing
2001:multiple drug resistance
1773:alanine aminotransferase
1717:Hematologic dysfunction
1225:bottles: orange cap for
716:
694:Diastolic blood pressure
376:increased breathing rate
148:increased breathing rate
10794:Intensive care medicine
10460:Membrane abnormalities
10200:Stress ulcer prevention
10144:Therapeutic hypothermia
10043:Central venous catheter
9711:Intensive care medicine
9490:considered for deletion
8942:10.1073/pnas.1222878110
8574:Journal of Bacteriology
8305:Intensive Care Medicine
7202:Minerva Anestesiologica
7045:Intensive Care Medicine
6967:10.21037/atm.2016.09.02
6652:Intensive Care Medicine
5674:Intensive Care Medicine
5352:Simpson SQ (May 2016).
4234:10.3402/jchimp.v5.29426
4181:10.4103/0972-5229.63029
3918:Martin GS (June 2012).
3606:10.1542/hpeds.2020-0174
3308:Intensive Care Medicine
2119:central venous pressure
2115:central venous catheter
2040:infection, addition of
2016:Acinetobacter baumannii
2005:multiple drug resistant
1945:, but if necessary, by
1711:intellectual disability
1693:Neurologic dysfunction
1612:oliguria (urine output
1490:include the following:
1274:central venous pressure
1239:white blood cell counts
1185:constrict blood vessels
534:central venous catheter
406:. Severe sepsis causes
10630:Red cell agglutination
10275:Level of consciousness
10082:mechanical ventilation
9980:Methicillin-resistant
9338:10.1001/jama.2019.7936
9191:Critical Care Medicine
9144:Critical Care Medicine
8681:10.1006/bcmd.1998.0201
7404:Critical Care Medicine
6863:Critical Care Medicine
6746:Critical Care Medicine
5940:Critical Care Medicine
5857:(Suppl 2): ii11–ii23.
5497:Critical Care Medicine
4995:Marik PE (June 2014).
4168:Indian J Crit Care Med
3979:Critical Care Medicine
3794:10.15585/mmwr.mm6513a2
3697:JAMA Internal Medicine
3552:Critical Care Medicine
3368:10.7189/jogh.01.010404
3214:10.1001/jama.2016.0287
2919:Pseudomonas aeruginosa
2879:
2788:gram-negative bacteria
2768:host and that soluble
2709:decay or decomposition
2704:
2588:ventricular arrhythmia
2540:venous thromboembolism
2532:unfractionated heparin
2445:and easier to obtain.
2389:mechanical ventilation
2339:abnormal heart rhythms
2321:less than 30 cm H
2240:abnormal heart rhythms
2215:mean arterial pressure
2158:packed red blood cells
2111:mean arterial pressure
2021:methicillin-resistant
2010:Pseudomonas aeruginosa
1931:mechanical ventilation
1902:
1871:blood stream infection
1869:refers to a bacterial
1819:differential diagnosis
1813:Differential diagnosis
1756:chronic kidney disease
1438:decreased urine output
1396:
1234:
1170:multiple organ failure
1138:central nervous system
1130:gastrointestinal tract
1122:adenosine triphosphate
1087:multiple organ failure
1015:nuclear factor-kappa B
812:Pseudomonas aeruginosa
800:Streptococcus pyogenes
791:gram-negative bacteria
787:Gram-positive bacteria
766:
677:drop in blood pressure
608:
526:Mechanical ventilation
396:weakened immune system
338:location and its staff
9982:Staphylococcus aureus
9471:Medical Knowledge app
8623:Journal of Immunology
8533:: Suppl:17–Suppl:29.
8356:John Wiley & Sons
8282:10.1056/NEJMcp1314291
6919:10.1378/chest.14-1012
6316:10.1056/NEJMoa1406617
6141:10.1001/jama.2013.430
5220:10.3399/bjgp17X693665
5104:All Things Considered
5077:10.1378/chest.13-2104
4959:Critical Care Clinics
4038:. pp. 1099–109.
3421:10.1056/NEJMra1208623
2986:National Public Radio
2960:phenotypic plasticity
2925:Staphylococcus aureus
2877:
2694:
2560:intravenous nutrition
2544:proton-pump inhibitor
2375:poor adrenal function
2273:adrenal insufficiency
2083:Once-daily dosing of
2023:Staphylococcus aureus
1900:
1847:adrenal insufficiency
1703:altered mental status
1638:cyanotic heart defect
1488:end-organ dysfunction
1476:End-organ dysfunction
1394:
1221:
1142:tumor necrosis factor
724:
654:respiratory alkalosis
602:
487:adrenal insufficiency
308:pneumonia vaccination
300:influenza vaccination
10804:Causes of amputation
10733:Alder–Reilly anomaly
10587:Basophilic stippling
9957:Stress hyperglycemia
9798:Organ system failure
9732:Medical specialities
9369:Nutrition and Health
8849:Drug Discovery Today
8812:10.1089/sur.2016.021
8512:10.1093/jnci/4.5.461
8156:10.1056/NEJMoa022139
8076:. pp. 2223–31.
7279:(Suppl 1): S24–S32.
7118:10.1056/NEJMoa010307
6221:(1): 185.e1–185.e7.
5834:on 19 December 2014.
3116:. pp. 1003–14.
3104:Jui J, et al. (
3064:(CDC). 22 May 2014.
2134:Crystalloid solution
2034:is recommended. For
1951:deep vein thrombosis
1947:parenteral nutrition
1670:) over baseline PaCO
1263:present in the blood
1191:, and activation of
1177:dilate blood vessels
1091:cytochrome c oxidase
1011:RIG-I-like receptors
971:inflammatory cascade
960:antigen presentation
896:chemical pneumonitis
753:(background right).
743:parenteral nutrition
622:low body temperature
553:deep vein thrombosis
522:raise blood pressure
475:blood to be infected
372:increased heart rate
138:increased heart rate
10799:Medical emergencies
10789:Infectious diseases
10708:Pelger–Huët anomaly
10666:Reactive lymphocyte
10592:Pappenheimer bodies
10523:Sickle cell disease
10320:Related specialties
10280:Acid–base imbalance
10216:ICU scoring systems
10087:Tracheal intubation
9898:Respiratory failure
9893:Acute liver failure
9883:Acute renal failure
9753:Intensive care unit
9737:Respiratory therapy
9283:2017InfGE..55..135R
9197:(11): e1063–e1143.
8933:2013PNAS..110.3507S
8800:Surgical Infections
8716:1998Sci...282.2085P
8710:(5396): 2085–2088.
8403:10.1189/jlb.0607380
8346:Vincent JL (2008).
8031:2014NYASA1323..101L
7712:10.3748/wjg.15.4132
6470:2015PLoSO..1029305A
4652:10.1038/emm.2013.97
4509:McGraw-Hill Medical
4288:. pp. 914–34.
3593:Hospital Pediatrics
2952:spp. and the fungi
2830:Society and culture
2695:Personification of
2665:absence of a spleen
2645:intensive care unit
2629:number of new cases
2592:torsades de pointes
2564:omega-3 fatty acids
2419:Ubi pus, ibi evacua
2365:function. Although
2182:Fresh frozen plasma
2166:myocardial ischemia
2146:acute kidney injury
2142:hydroxyethyl starch
1972:β-lactam antibiotic
1743:Kidney dysfunction
1707:developmental delay
1679:respiratory failure
1666:) > 65 torr (20
1642:respiratory disease
1640:or a known chronic
1331:
1255:anaerobic organisms
1245:using bottles with
1118:acute kidney injury
1112:transport, causing
1019:activator protein-1
999:toll-like receptors
934:. Sepsis caused by
727:intensive care unit
662:vascular resistance
642:decreased urination
524:becomes necessary.
514:intensive care unit
408:poor organ function
10556:Hypochromic anemia
10229:Glasgow Coma Scale
10180:Intravenous fluids
10060:Screening cultures
10028:Arterial blood gas
9993:Refeeding syndrome
9910:Neonatal infection
9871:Vasodilatory shock
9846:Distributive shock
9771:Coronary care unit
9634:External resources
8980:Burns & Trauma
8039:10.1111/nyas.12444
5864:10.1093/jac/dkq515
5735:10.4161/viru.27372
5214:(665): e859–e870.
4701:10.4161/viru.25965
4459:10.4161/viru.26187
4410:10.4161/viru.27024
4119:Clinical Nutrition
3868:(10219): 200–211.
2880:
2826:for intervention.
2807:toll-like receptor
2792:lipopolysaccharide
2705:
2524:sodium bicarbonate
2406:focus of infection
2100:Intravenous fluids
2074:acute pancreatitis
2007:organisms such as
1957:also may be used.
1903:
1835:pulmonary embolism
1827:acute pancreatitis
1823:alcohol withdrawal
1769:≥ 4 mg/dL, or
1697:Glasgow Coma Score
1597:metabolic acidosis
1450:low blood pressure
1397:
1327:
1235:
1201:distributive shock
1083:regulatory T cells
1007:NOD-like receptors
958:in the absence of
928:lipopolysaccharide
767:
658:low blood pressure
650:metabolic acidosis
612:Signs and symptoms
609:
546:superior vena cava
506:intravenous fluids
499:pulmonary embolism
412:low blood pressure
318:Intravenous fluids
143:low blood pressure
118:Infectious disease
10771:
10770:
10767:
10766:
10723:Toxic vacuolation
10718:Toxic granulation
10649:White blood cells
10643:
10642:
10582:Howell–Jolly body
10372:
10371:
10332:Internal medicine
10078:Airway management
10016:
10015:
9856:Obstructive shock
9841:Cardiogenic shock
9677:
9676:
9422:(12): 4449–4460.
9234:Sepsis Alliance.
8149:(16): 1546–1554.
8025:(2014): 101–114.
7980:(11): 1150–1157.
7705:(33): 4132–4136.
7208:(10): 1138–1143.
7111:(19): 1368–1377.
7018:978-3-540-92275-9
6869:(11): 2945–2953.
6309:(15): 1381–1391.
6266:10.1136/bmj.g4561
5915:on 11 August 2014
5905:978-1-909103-26-9
5503:(10): 2408–2416.
5309:Clinical Medicine
4831:10.2217/imt.10.82
4790:(12): 1287–1293.
4550:10.1111/bph.12829
4544:(22): 5011–5031.
3936:10.1586/eri.12.50
3599:(12): 1021–1030.
2994:systematic review
2846:private insurance
2568:prokinetic agents
2492:drotrecogin alpha
2221:are recommended.
1657:acute lung injury
1389:
1388:
1317:purpura fulminans
1197:circulatory shock
1043:immunosuppression
991:CpG bacterial DNA
983:muramyl dipeptide
940:lipoteichoic acid
908:virulence factors
902:Microbial factors
706:systolic pressure
630:a fast heart rate
600:
549:oxygen saturation
538:arterial catheter
518:fluid replacement
428:fluid replacement
388:painful urination
350:
349:
281:Diagnostic method
42:Medical condition
30:For the fly, see
16:(Redirected from
10816:
10738:Jordans' anomaly
10654:
10653:
10571:Inclusion bodies
10420:
10419:
10399:
10392:
10385:
10376:
10375:
10093:Cardiac devices
9947:Decubitus ulcers
9861:Neurogenic shock
9795:
9794:
9704:
9697:
9690:
9681:
9680:
9530:
9529:
9525:
9493:
9466:
9450:
9449:
9439:
9407:
9401:
9400:
9364:
9358:
9357:
9321:
9315:
9314:
9304:
9294:
9262:
9256:
9255:
9253:
9251:
9231:
9225:
9224:
9206:
9182:
9176:
9175:
9135:
9129:
9128:
9126:
9124:
9099:
9093:
9092:
9066:
9060:
9059:
9025:
9016:
9015:
9005:
8995:
8971:
8965:
8964:
8954:
8944:
8927:(9): 3507–3512.
8912:
8906:
8905:
8889:
8883:
8882:
8872:
8855:(9): 1540–1552.
8840:
8834:
8833:
8823:
8791:
8785:
8784:
8766:
8742:
8736:
8735:
8699:
8693:
8692:
8663:
8657:
8656:
8638:
8614:
8608:
8607:
8597:
8565:
8559:
8558:
8522:
8516:
8515:
8493:
8487:
8486:
8484:
8482:
8458:
8452:
8451:
8449:
8447:
8432:
8423:
8422:
8396:
8376:
8370:
8369:
8343:
8337:
8336:
8300:
8294:
8293:
8265:
8259:
8258:
8248:
8216:
8210:
8209:
8175:
8169:
8168:
8158:
8134:
8128:
8127:
8097:
8088:
8087:
8065:
8059:
8058:
8014:
8008:
8007:
7997:
7965:
7959:
7958:
7929:
7923:
7922:
7912:
7902:
7878:
7872:
7871:
7835:
7829:
7828:
7818:
7808:
7784:
7778:
7777:
7741:
7735:
7734:
7724:
7714:
7690:
7684:
7683:
7647:
7641:
7640:
7630:
7613:(12): CD004388.
7598:
7589:
7588:
7578:
7546:
7540:
7539:
7529:
7519:
7495:
7489:
7488:
7478:
7468:
7444:
7438:
7437:
7427:
7395:
7389:
7388:
7352:
7346:
7345:
7335:
7303:
7297:
7296:
7268:
7262:
7261:
7224:
7218:
7217:
7197:
7188:
7187:
7177:
7145:
7139:
7138:
7120:
7092:
7079:
7078:
7068:
7036:
7023:
7022:
6996:
6990:
6989:
6979:
6969:
6945:
6939:
6938:
6901:
6895:
6894:
6858:
6852:
6851:
6815:
6809:
6808:
6784:
6778:
6777:
6752:(6): 1937–1949.
6740:
6729:
6728:
6703:(9): 1657–1664.
6692:
6686:
6685:
6675:
6658:(7): 1220–1234.
6643:
6637:
6636:
6608:
6602:
6601:
6591:
6559:
6548:
6547:
6511:
6502:
6501:
6491:
6481:
6449:
6440:
6439:
6429:
6419:
6395:
6389:
6388:
6378:
6346:
6337:
6336:
6318:
6294:
6288:
6287:
6277:
6245:
6239:
6238:
6209:
6203:
6202:
6192:
6181:10.1136/bmj.f839
6160:
6154:
6153:
6143:
6119:
6113:
6112:
6102:
6070:
6059:
6058:
6048:
6016:
6010:
6009:
5980:
5974:
5973:
5963:
5946:(9): 1907–1915.
5931:
5925:
5924:
5922:
5920:
5914:
5908:. Archived from
5897:
5883:
5877:
5876:
5866:
5842:
5836:
5835:
5833:
5827:. Archived from
5810:
5801:
5792:
5791:
5763:
5757:
5756:
5746:
5714:
5708:
5707:
5697:
5680:(9): 1418–1428.
5665:
5656:
5655:
5653:
5629:
5623:
5622:
5612:
5602:
5578:
5572:
5571:
5535:
5529:
5528:
5492:
5486:
5485:
5466:10.7326/M17-2820
5448:
5442:
5441:
5428:
5418:
5394:
5388:
5387:
5373:
5364:(5): 1117–1118.
5349:
5343:
5342:
5332:
5300:
5287:
5286:
5248:
5242:
5241:
5231:
5199:
5193:
5192:
5160:
5149:
5148:
5146:
5144:
5138:
5130:
5124:
5123:
5121:
5119:
5095:
5089:
5088:
5070:
5061:(6): 1407–1418.
5050:
5037:
5036:
5026:
5016:
4992:
4983:
4982:
4954:
4948:
4947:
4937:
4927:
4903:
4897:
4896:
4886:
4854:
4843:
4842:
4814:
4808:
4807:
4778:
4772:
4771:
4761:
4729:
4723:
4722:
4712:
4680:
4674:
4673:
4663:
4631:
4625:
4624:
4604:(6): 1644–1655.
4581:
4572:
4571:
4561:
4529:
4523:
4522:
4500:
4481:
4480:
4470:
4438:
4432:
4431:
4421:
4389:
4383:
4382:
4360:
4354:
4353:
4343:
4311:
4300:
4299:
4269:
4256:
4255:
4245:
4213:
4204:
4203:
4193:
4183:
4159:
4153:
4152:
4134:
4110:
4104:
4092:
4086:
4085:
4065:
4050:
4049:
4027:
4018:
4017:
4015:
3985:(4): 1250–1256.
3976:
3967:
3958:
3957:
3947:
3915:
3906:
3905:
3895:
3885:
3853:
3842:
3841:
3813:
3807:
3806:
3796:
3772:
3766:
3765:
3737:
3731:
3730:
3720:
3688:
3679:
3678:
3668:
3651:(12): CD002243.
3636:
3627:
3626:
3608:
3584:
3578:
3577:
3567:
3543:
3488:
3487:
3477:
3445:
3434:
3433:
3423:
3399:
3390:
3389:
3379:
3347:
3334:
3333:
3323:
3299:
3236:
3235:
3225:
3193:
3172:
3171:
3161:
3137:
3128:
3127:
3101:
3078:
3077:
3075:
3073:
3050:
3013:pupura fulminans
2907:Escherichia coli
2776:coined the term
2508:high blood sugar
2478:N-acetylcysteine
2381:Paralytic agents
2319:plateau pressure
2160:transfusion for
1980:fluoroquinolones
1970:(usually two, a
1851:neurogenic shock
1726:
1629:
1621:capillary refill
1615:
1614:< 0.5 mL/kg/h
1566:chemical signals
1564:, likely due to
1544:low urine output
1529:clotting factors
1422:white blood cell
1414:respiratory rate
1406:body temperature
1364:Respiratory rate
1332:
1326:
1303:consistent with
1259:through the skin
1229:, green cap for
1162:antifibrinolysis
956:T-cell receptors
845:(which leads to
806:Escherichia coli
761:malfunction and
646:high blood sugar
601:
491:low blood volume
467:quick SOFA score
439:abdominal organs
420:low urine output
400:body temperature
392:kidney infection
266:multiple myeloma
237:Young or old age
153:low urine output
103:
102:
99:
98:
95:
92:
89:
86:
83:
80:
57:
45:
44:
21:
10824:
10823:
10819:
10818:
10817:
10815:
10814:
10813:
10774:
10773:
10772:
10763:
10747:
10682:
10639:
10613:
10565:
10539:
10444:
10415:Red blood cells
10409:
10403:
10373:
10368:
10315:
10289:
10253:
10210:
10170:Antithrombotics
10148:
10132:Enteral feeding
10114:Kidney dialysis
10064:
10012:
9988:Oxygen toxicity
9966:
9924:
9786:
9741:
9713:
9708:
9678:
9673:
9672:
9629:
9628:
9541:
9516:
9512:Wayback Machine
9478:
9475:
9467:
9459:
9454:
9453:
9408:
9404:
9365:
9361:
9322:
9318:
9263:
9259:
9249:
9247:
9232:
9228:
9183:
9179:
9136:
9132:
9122:
9120:
9101:
9100:
9096:
9067:
9063:
9026:
9019:
8972:
8968:
8913:
8909:
8890:
8886:
8841:
8837:
8792:
8788:
8743:
8739:
8700:
8696:
8664:
8660:
8615:
8611:
8566:
8562:
8523:
8519:
8494:
8490:
8480:
8478:
8472:Merck & Co.
8460:
8459:
8455:
8445:
8443:
8433:
8426:
8394:10.1.1.492.7774
8377:
8373:
8366:
8344:
8340:
8301:
8297:
8266:
8262:
8217:
8213:
8176:
8172:
8135:
8131:
8098:
8091:
8084:
8066:
8062:
8015:
8011:
7966:
7962:
7930:
7926:
7879:
7875:
7836:
7832:
7785:
7781:
7742:
7738:
7691:
7687:
7664:10.1038/nrd4368
7658:(10): 741–758.
7648:
7644:
7599:
7592:
7561:(9): CD006616.
7547:
7543:
7517:10.1186/cc10097
7496:
7492:
7466:10.1186/cc13153
7445:
7441:
7396:
7392:
7353:
7349:
7304:
7300:
7269:
7265:
7225:
7221:
7198:
7191:
7146:
7142:
7093:
7082:
7037:
7026:
7019:
6997:
6993:
6946:
6942:
6902:
6898:
6859:
6855:
6820:Pharmacotherapy
6816:
6812:
6785:
6781:
6741:
6732:
6693:
6689:
6644:
6640:
6609:
6605:
6560:
6551:
6512:
6505:
6464:(8): e0129305.
6450:
6443:
6396:
6392:
6361:(9): CD001090.
6347:
6340:
6295:
6291:
6246:
6242:
6210:
6206:
6161:
6157:
6120:
6116:
6085:(8): CD000567.
6071:
6062:
6017:
6013:
5981:
5977:
5932:
5928:
5918:
5916:
5912:
5906:
5895:
5884:
5880:
5843:
5839:
5831:
5808:
5802:
5795:
5764:
5760:
5715:
5711:
5666:
5659:
5630:
5626:
5579:
5575:
5536:
5532:
5493:
5489:
5449:
5445:
5395:
5391:
5350:
5346:
5301:
5290:
5249:
5245:
5200:
5196:
5161:
5152:
5142:
5140:
5136:
5132:
5131:
5127:
5117:
5115:
5096:
5092:
5068:10.1.1.661.7518
5051:
5040:
4993:
4986:
4955:
4951:
4904:
4900:
4855:
4846:
4815:
4811:
4779:
4775:
4730:
4726:
4681:
4677:
4632:
4628:
4592:) (June 1992).
4582:
4575:
4530:
4526:
4519:
4501:
4484:
4439:
4435:
4390:
4386:
4379:
4361:
4357:
4312:
4303:
4296:
4270:
4259:
4214:
4207:
4160:
4156:
4111:
4107:
4093:
4089:
4066:
4053:
4046:
4028:
4021:
4013:
3974:
3968:
3961:
3916:
3909:
3854:
3845:
3814:
3810:
3787:(13): 342–345.
3773:
3769:
3738:
3734:
3689:
3682:
3637:
3630:
3585:
3581:
3544:
3491:
3446:
3437:
3400:
3393:
3348:
3337:
3300:
3239:
3194:
3175:
3138:
3131:
3124:
3102:
3081:
3071:
3069:
3052:
3051:
3028:
3023:
3016:
3005:
2872:
2864:Sepsis Alliance
2854:
2837:
2832:
2783:Vibrio cholerae
2689:
2625:
2604:
2476:concluded that
2474:Cochrane review
2467:
2458:Neonatal sepsis
2455:
2444:
2436:
2428:
2410:drainage of pus
2402:
2324:
2311:
2277:corticosteroids
2261:glucocorticoids
2253:
2211:
2154:
2102:
2046:fluoroquinolone
1988:aminoglycosides
1963:
1943:enteral feeding
1895:
1887:gastroenteritis
1867:neonatal sepsis
1863:
1861:Neonatal sepsis
1815:
1787:
1754:in people with
1724:
1687:
1673:
1665:
1654:
1650:
1627:
1613:
1607:lactic acidosis
1589:requirement, or
1556:volume overload
1548:no urine output
1507:
1503:
1484:
1478:
1325:
1209:
1156:factors in the
1134:paralytic ileus
1102:pulmonary edema
1071:dendritic cells
1027:
1005:receptors, the
904:
871:
869:Pathophysiology
719:
681:lightheadedness
626:rapid breathing
614:
603:Video summary (
590:
581:developed world
573:corticosteroids
561:pressure ulcers
479:Medical imaging
275:
222:Immune response
205:
172:
107:
77:
73:
43:
38:
28:
23:
22:
15:
12:
11:
5:
10822:
10812:
10811:
10806:
10801:
10796:
10791:
10786:
10769:
10768:
10765:
10764:
10762:
10761:
10755:
10753:
10749:
10748:
10746:
10745:
10740:
10735:
10730:
10725:
10720:
10715:
10710:
10705:
10704:
10703:
10692:
10690:
10684:
10683:
10681:
10680:
10679:
10678:
10676:Russell bodies
10668:
10662:
10660:
10651:
10645:
10644:
10641:
10640:
10638:
10637:
10632:
10627:
10621:
10619:
10615:
10614:
10612:
10611:
10610:
10609:
10601:
10600:
10599:
10594:
10589:
10584:
10578:Developmental
10575:
10573:
10567:
10566:
10564:
10563:
10558:
10553:
10547:
10545:
10541:
10540:
10538:
10537:
10536:
10535:
10527:
10526:
10525:
10517:
10512:
10507:
10502:
10497:
10496:
10495:
10494:
10493:
10483:
10482:
10481:
10471:
10466:
10458:
10456:Poikilocytosis
10452:
10450:
10446:
10445:
10443:
10442:
10437:
10432:
10426:
10424:
10417:
10411:
10410:
10402:
10401:
10394:
10387:
10379:
10370:
10369:
10367:
10366:
10361:
10356:
10351:
10350:
10349:
10344:
10339:
10329:
10327:Anesthesiology
10323:
10321:
10317:
10316:
10314:
10313:
10308:
10303:
10297:
10295:
10291:
10290:
10288:
10287:
10282:
10277:
10272:
10267:
10261:
10259:
10255:
10254:
10252:
10251:
10246:
10241:
10236:
10231:
10226:
10224:APACHE II
10220:
10218:
10212:
10211:
10209:
10208:
10203:
10197:
10192:
10187:
10182:
10177:
10172:
10167:
10162:
10156:
10154:
10150:
10149:
10147:
10146:
10141:
10140:
10139:
10134:
10126:
10121:
10116:
10111:
10106:
10105:
10104:
10099:
10091:
10090:
10089:
10074:
10072:
10066:
10065:
10063:
10062:
10057:
10055:Blood cultures
10052:
10051:
10050:
10045:
10040:
10030:
10024:
10022:
10018:
10017:
10014:
10013:
10011:
10010:
10005:
10000:
9995:
9990:
9985:
9976:
9974:
9968:
9967:
9965:
9964:
9959:
9954:
9949:
9944:
9939:
9932:
9930:
9926:
9925:
9923:
9922:
9917:
9912:
9906:
9905:
9900:
9895:
9890:
9885:
9880:
9874:
9873:
9868:
9863:
9858:
9853:
9848:
9843:
9838:
9831:
9830:
9825:
9820:
9815:
9810:
9805:
9804:Shock sequence
9801:
9799:
9792:
9788:
9787:
9785:
9784:
9779:
9774:
9768:
9762:
9756:
9749:
9747:
9743:
9742:
9740:
9739:
9734:
9729:
9724:
9722:Health science
9718:
9715:
9714:
9707:
9706:
9699:
9692:
9684:
9675:
9674:
9671:
9670:
9661:
9650:
9638:
9637:
9635:
9631:
9630:
9627:
9626:
9615:
9604:
9589:
9562:
9542:
9537:
9536:
9534:
9533:Classification
9527:
9526:
9514:
9502:
9461:
9460:
9458:
9457:External links
9455:
9452:
9451:
9402:
9359:
9332:(4): 291–293.
9316:
9257:
9226:
9177:
9150:(3): 486–552.
9130:
9094:
9061:
9017:
8966:
8907:
8894:"Septic Shock"
8884:
8835:
8806:(4): 385–393.
8786:
8757:(5): 799–814.
8737:
8694:
8675:(3): 340–355.
8658:
8609:
8580:(3): 696–703.
8560:
8517:
8488:
8453:
8424:
8387:(3): 471–482.
8371:
8364:
8338:
8295:
8276:(4): 349–356.
8260:
8231:(4): 379–388.
8211:
8170:
8129:
8089:
8082:
8060:
8009:
7960:
7941:(3): 319–327.
7924:
7873:
7846:(2): 193–201.
7830:
7779:
7736:
7685:
7642:
7590:
7541:
7490:
7439:
7410:(5): 806–813.
7390:
7363:(3): 333–337.
7347:
7318:(2): 367–389.
7298:
7263:
7236:(6): 731–743.
7219:
7189:
7160:(3): 267–272.
7140:
7080:
7024:
7017:
6991:
6940:
6913:(2): 335–346.
6896:
6853:
6826:(5): 475–482.
6810:
6779:
6730:
6687:
6638:
6619:(2): 133–139.
6603:
6574:(4): 490–498.
6549:
6522:(4): 342–347.
6503:
6441:
6390:
6338:
6289:
6240:
6204:
6155:
6134:(7): 678–688.
6114:
6060:
6011:
5992:(6): 681–691.
5975:
5926:
5904:
5878:
5837:
5819:(5): 449–457.
5793:
5758:
5709:
5657:
5624:
5600:10.1186/cc8872
5573:
5530:
5487:
5460:(4): 266–275.
5443:
5389:
5344:
5315:(3): 276–280.
5288:
5269:(6): 1644–55.
5243:
5194:
5175:(5): 426–435.
5150:
5125:
5090:
5038:
4984:
4965:(3): 441–458.
4949:
4898:
4844:
4825:(1): 117–128.
4809:
4773:
4744:(3): 521–540.
4724:
4695:(1): 219–225.
4675:
4626:
4573:
4524:
4518:978-0071416405
4517:
4482:
4453:(1): 161–169.
4433:
4404:(1): 213–218.
4384:
4377:
4355:
4301:
4294:
4257:
4205:
4154:
4105:
4087:
4051:
4045:978-0071603898
4044:
4019:
3959:
3930:(6): 701–706.
3907:
3843:
3808:
3767:
3748:(5): 653–661.
3732:
3703:(2): 213–223.
3680:
3628:
3579:
3558:(2): 580–637.
3489:
3435:
3414:(9): 840–851.
3391:
3335:
3314:(3): 304–377.
3237:
3208:(8): 801–810.
3173:
3152:(4): 463–475.
3129:
3122:
3079:
3025:
3024:
3022:
3019:
3018:
3017:
3004:
3001:
2982:intensive care
2970:hydrocortisone
2871:
2868:
2853:
2850:
2836:
2833:
2831:
2828:
2688:
2685:
2624:
2621:
2603:
2600:
2572:metoclopramide
2506:In those with
2466:
2463:
2454:
2451:
2442:
2434:
2427:
2424:
2401:
2400:Source control
2398:
2322:
2310:
2307:
2265:hydrocortisone
2252:
2249:
2223:Norepinephrine
2210:
2207:
2178:blood clotting
2174:Erythropoietin
2153:
2152:Blood products
2150:
2101:
2098:
2085:aminoglycoside
1978:combined with
1962:
1959:
1955:gastric ulcers
1939:blood products
1927:kidney failure
1912:United Kingdom
1894:
1891:
1883:pyelonephritis
1862:
1859:
1839:thyrotoxicosis
1814:
1811:
1786:
1783:
1779:
1778:
1777:
1776:
1770:
1760:
1759:
1758:
1741:
1740:
1739:
1734:
1728:
1725:< 80,000/mm
1715:
1714:
1713:
1700:
1699:(GCS) ≤ 11, or
1691:
1690:
1689:
1685:
1682:
1671:
1663:
1660:
1652:
1648:
1634:
1633:
1632:
1631:
1630:
1624:
1623:> 5 seconds
1617:
1610:
1604:
1590:
1584:
1574:
1573:
1558:
1540:
1521:
1518:encephalopathy
1514:
1505:
1501:
1480:Main article:
1477:
1474:
1454:
1453:
1441:
1431:
1425:
1387:
1386:
1380:
1374:
1373:
1368:>20/min or
1366:
1360:
1359:
1356:
1350:
1349:
1346:
1340:
1339:
1336:
1324:
1321:
1297:internal organ
1243:blood cultures
1208:
1205:
1154:procoagulation
1051:interleukin 10
1026:
1023:
966:) by T-cells.
930:, also called
903:
900:
876:cytokine storm
870:
867:
751:infusion pumps
731:chain reaction
725:Patient of an
718:
715:
698:pulse pressure
666:cardiac output
613:
610:
542:cardiac output
510:antimicrobials
471:blood cultures
348:
347:
344:
340:
339:
335:
329:
328:
322:antimicrobials
315:
311:
310:
297:
293:
292:
283:
277:
276:
274:
273:
268:
263:
258:
253:
248:
243:
238:
234:
232:
226:
225:
219:
215:
214:
211:
207:
206:
204:
203:
198:
193:
188:
182:
180:
174:
173:
171:
170:
165:
160:
155:
150:
145:
140:
135:
129:
127:
121:
120:
115:
109:
108:
106:
105:
70:
68:
64:
63:
59:
58:
50:
49:
41:
26:
9:
6:
4:
3:
2:
10821:
10810:
10807:
10805:
10802:
10800:
10797:
10795:
10792:
10790:
10787:
10785:
10782:
10781:
10779:
10760:
10757:
10756:
10754:
10750:
10744:
10741:
10739:
10736:
10734:
10731:
10729:
10726:
10724:
10721:
10719:
10716:
10714:
10711:
10709:
10706:
10702:
10699:
10698:
10697:
10694:
10693:
10691:
10689:
10685:
10677:
10674:
10673:
10672:
10669:
10667:
10664:
10663:
10661:
10659:
10655:
10652:
10650:
10646:
10636:
10633:
10631:
10628:
10626:
10623:
10622:
10620:
10616:
10608:
10605:
10604:
10602:
10598:
10595:
10593:
10590:
10588:
10585:
10583:
10580:
10579:
10577:
10576:
10574:
10572:
10568:
10562:
10561:Polychromasia
10559:
10557:
10554:
10552:
10549:
10548:
10546:
10542:
10534:
10531:
10530:
10528:
10524:
10521:
10520:
10518:
10516:
10513:
10511:
10508:
10506:
10503:
10501:
10498:
10492:
10489:
10488:
10487:
10484:
10480:
10477:
10476:
10475:
10472:
10470:
10467:
10465:
10462:
10461:
10459:
10457:
10454:
10453:
10451:
10447:
10441:
10438:
10436:
10433:
10431:
10428:
10427:
10425:
10421:
10418:
10416:
10412:
10407:
10400:
10395:
10393:
10388:
10386:
10381:
10380:
10377:
10365:
10362:
10360:
10357:
10355:
10352:
10348:
10345:
10343:
10340:
10338:
10335:
10334:
10333:
10330:
10328:
10325:
10324:
10322:
10318:
10312:
10309:
10307:
10304:
10302:
10299:
10298:
10296:
10294:Organisations
10292:
10286:
10283:
10281:
10278:
10276:
10273:
10271:
10268:
10266:
10263:
10262:
10260:
10256:
10250:
10247:
10245:
10244:SAPS III
10242:
10240:
10237:
10235:
10232:
10230:
10227:
10225:
10222:
10221:
10219:
10217:
10213:
10207:
10204:
10201:
10198:
10196:
10193:
10191:
10188:
10186:
10183:
10181:
10178:
10176:
10173:
10171:
10168:
10166:
10163:
10161:
10158:
10157:
10155:
10151:
10145:
10142:
10138:
10135:
10133:
10130:
10129:
10127:
10125:
10122:
10120:
10117:
10115:
10112:
10110:
10107:
10103:
10100:
10098:
10095:
10094:
10092:
10088:
10085:
10084:
10083:
10079:
10076:
10075:
10073:
10071:
10067:
10061:
10058:
10056:
10053:
10049:
10046:
10044:
10041:
10039:
10038:Arterial line
10036:
10035:
10034:
10031:
10029:
10026:
10025:
10023:
10019:
10009:
10006:
10004:
10001:
9999:
9996:
9994:
9991:
9989:
9986:
9984:
9983:
9978:
9977:
9975:
9973:
9969:
9963:
9960:
9958:
9955:
9953:
9950:
9948:
9945:
9943:
9940:
9937:
9934:
9933:
9931:
9929:Complications
9927:
9921:
9918:
9916:
9913:
9911:
9908:
9907:
9904:
9901:
9899:
9896:
9894:
9891:
9889:
9886:
9884:
9881:
9879:
9878:Organ failure
9876:
9875:
9872:
9869:
9867:
9864:
9862:
9859:
9857:
9854:
9852:
9849:
9847:
9844:
9842:
9839:
9837:
9833:
9832:
9829:
9826:
9824:
9821:
9819:
9818:Severe sepsis
9816:
9814:
9811:
9809:
9806:
9803:
9802:
9800:
9796:
9793:
9789:
9783:
9780:
9778:
9775:
9772:
9769:
9766:
9763:
9760:
9757:
9754:
9751:
9750:
9748:
9746:General terms
9744:
9738:
9735:
9733:
9730:
9728:
9725:
9723:
9720:
9719:
9716:
9712:
9705:
9700:
9698:
9693:
9691:
9686:
9685:
9682:
9669:
9665:
9662:
9660:
9656:
9655:
9651:
9649:
9645:
9644:
9640:
9639:
9636:
9632:
9625:
9621:
9620:
9616:
9614:
9610:
9609:
9605:
9603:
9599:
9598:
9594:
9590:
9588:
9584:
9580:
9576:
9572:
9571:
9567:
9563:
9561:
9557:
9553:
9552:
9548:
9544:
9543:
9540:
9535:
9531:
9523:
9519:
9515:
9513:
9509:
9506:
9503:
9501:
9497:
9491:
9487:
9486:
9482:
9477:
9476:
9473:
9472:
9465:
9447:
9443:
9438:
9433:
9429:
9425:
9421:
9417:
9413:
9406:
9398:
9394:
9390:
9386:
9382:
9378:
9374:
9370:
9363:
9355:
9351:
9347:
9343:
9339:
9335:
9331:
9327:
9320:
9312:
9308:
9303:
9298:
9293:
9288:
9284:
9280:
9276:
9272:
9268:
9261:
9245:
9241:
9237:
9230:
9222:
9218:
9214:
9210:
9205:
9200:
9196:
9192:
9188:
9181:
9173:
9169:
9165:
9161:
9157:
9153:
9149:
9145:
9141:
9134:
9118:
9114:
9110:
9109:
9104:
9098:
9090:
9086:
9082:
9078:
9077:
9072:
9065:
9057:
9053:
9049:
9045:
9041:
9037:
9036:
9031:
9024:
9022:
9013:
9009:
9004:
8999:
8994:
8989:
8985:
8981:
8977:
8970:
8962:
8958:
8953:
8948:
8943:
8938:
8934:
8930:
8926:
8922:
8918:
8911:
8903:
8899:
8895:
8888:
8880:
8876:
8871:
8866:
8862:
8858:
8854:
8850:
8846:
8839:
8831:
8827:
8822:
8817:
8813:
8809:
8805:
8801:
8797:
8790:
8782:
8778:
8774:
8770:
8765:
8760:
8756:
8752:
8748:
8741:
8733:
8729:
8725:
8721:
8717:
8713:
8709:
8705:
8698:
8690:
8686:
8682:
8678:
8674:
8670:
8662:
8654:
8650:
8646:
8642:
8637:
8632:
8628:
8624:
8620:
8613:
8605:
8601:
8596:
8591:
8587:
8583:
8579:
8575:
8571:
8564:
8556:
8552:
8548:
8544:
8540:
8536:
8532:
8528:
8521:
8513:
8509:
8506:(5): 461–76.
8505:
8501:
8500:
8492:
8476:
8473:
8469:
8468:
8463:
8457:
8442:
8438:
8431:
8429:
8420:
8416:
8412:
8408:
8404:
8400:
8395:
8390:
8386:
8382:
8375:
8367:
8365:9783527319350
8361:
8358:. p. 3.
8357:
8353:
8349:
8342:
8334:
8330:
8326:
8322:
8318:
8314:
8310:
8306:
8299:
8291:
8287:
8283:
8279:
8275:
8271:
8264:
8256:
8252:
8247:
8242:
8238:
8234:
8230:
8226:
8222:
8215:
8207:
8203:
8199:
8195:
8191:
8187:
8186:
8181:
8174:
8166:
8162:
8157:
8152:
8148:
8144:
8140:
8133:
8125:
8121:
8117:
8113:
8109:
8108:
8103:
8096:
8094:
8085:
8083:9780071748896
8079:
8075:
8071:
8064:
8056:
8052:
8048:
8044:
8040:
8036:
8032:
8028:
8024:
8020:
8013:
8005:
8001:
7996:
7991:
7987:
7983:
7979:
7975:
7971:
7964:
7956:
7952:
7948:
7944:
7940:
7936:
7928:
7920:
7916:
7911:
7906:
7901:
7896:
7892:
7888:
7887:Critical Care
7884:
7877:
7869:
7865:
7861:
7857:
7853:
7849:
7845:
7841:
7834:
7826:
7822:
7817:
7812:
7807:
7802:
7798:
7794:
7790:
7783:
7775:
7771:
7767:
7763:
7759:
7755:
7752:(2): 281–90.
7751:
7747:
7740:
7732:
7728:
7723:
7718:
7713:
7708:
7704:
7700:
7696:
7689:
7681:
7677:
7673:
7669:
7665:
7661:
7657:
7653:
7646:
7638:
7634:
7629:
7624:
7620:
7616:
7612:
7608:
7604:
7597:
7595:
7586:
7582:
7577:
7572:
7568:
7564:
7560:
7556:
7552:
7545:
7537:
7533:
7528:
7523:
7518:
7513:
7509:
7505:
7504:Critical Care
7501:
7494:
7486:
7482:
7477:
7472:
7467:
7462:
7458:
7454:
7453:Critical Care
7450:
7443:
7435:
7431:
7426:
7421:
7417:
7413:
7409:
7405:
7401:
7394:
7386:
7382:
7378:
7374:
7370:
7366:
7362:
7358:
7351:
7343:
7339:
7334:
7329:
7325:
7321:
7317:
7313:
7309:
7302:
7294:
7290:
7286:
7282:
7278:
7274:
7267:
7259:
7255:
7251:
7247:
7243:
7239:
7235:
7231:
7223:
7215:
7211:
7207:
7203:
7196:
7194:
7185:
7181:
7176:
7171:
7167:
7163:
7159:
7155:
7151:
7144:
7136:
7132:
7128:
7124:
7119:
7114:
7110:
7106:
7102:
7098:
7091:
7089:
7087:
7085:
7076:
7072:
7067:
7062:
7058:
7054:
7050:
7046:
7042:
7035:
7033:
7031:
7029:
7020:
7014:
7010:
7006:
7002:
6995:
6987:
6983:
6978:
6973:
6968:
6963:
6959:
6955:
6951:
6944:
6936:
6932:
6928:
6924:
6920:
6916:
6912:
6908:
6900:
6892:
6888:
6884:
6880:
6876:
6872:
6868:
6864:
6857:
6849:
6845:
6841:
6837:
6833:
6829:
6825:
6821:
6814:
6806:
6802:
6798:
6794:
6790:
6783:
6775:
6771:
6767:
6763:
6759:
6755:
6751:
6747:
6739:
6737:
6735:
6726:
6722:
6718:
6714:
6710:
6706:
6702:
6698:
6691:
6683:
6679:
6674:
6669:
6665:
6661:
6657:
6653:
6649:
6642:
6634:
6630:
6626:
6622:
6618:
6614:
6607:
6599:
6595:
6590:
6585:
6581:
6577:
6573:
6569:
6565:
6558:
6556:
6554:
6545:
6541:
6537:
6533:
6529:
6525:
6521:
6517:
6510:
6508:
6499:
6495:
6490:
6485:
6480:
6475:
6471:
6467:
6463:
6459:
6455:
6448:
6446:
6437:
6433:
6428:
6423:
6418:
6413:
6409:
6405:
6404:Critical Care
6401:
6394:
6386:
6382:
6377:
6372:
6368:
6364:
6360:
6356:
6352:
6345:
6343:
6334:
6330:
6326:
6322:
6317:
6312:
6308:
6304:
6300:
6293:
6285:
6281:
6276:
6271:
6267:
6263:
6259:
6255:
6251:
6244:
6236:
6232:
6228:
6224:
6220:
6216:
6208:
6200:
6196:
6191:
6186:
6182:
6178:
6174:
6170:
6166:
6159:
6151:
6147:
6142:
6137:
6133:
6129:
6125:
6118:
6110:
6106:
6101:
6096:
6092:
6088:
6084:
6080:
6076:
6069:
6067:
6065:
6056:
6052:
6047:
6042:
6038:
6034:
6030:
6026:
6022:
6015:
6007:
6003:
5999:
5995:
5991:
5987:
5979:
5971:
5967:
5962:
5957:
5953:
5949:
5945:
5941:
5937:
5930:
5911:
5907:
5901:
5894:
5893:
5888:
5882:
5874:
5870:
5865:
5860:
5856:
5852:
5848:
5841:
5830:
5826:
5822:
5818:
5814:
5807:
5800:
5798:
5789:
5785:
5781:
5777:
5773:
5769:
5762:
5754:
5750:
5745:
5740:
5736:
5732:
5728:
5724:
5720:
5713:
5705:
5701:
5696:
5691:
5687:
5683:
5679:
5675:
5671:
5664:
5662:
5652:
5647:
5643:
5639:
5635:
5628:
5620:
5616:
5611:
5606:
5601:
5596:
5592:
5588:
5587:Critical Care
5584:
5577:
5569:
5565:
5561:
5557:
5553:
5549:
5545:
5541:
5534:
5526:
5522:
5518:
5514:
5510:
5506:
5502:
5498:
5491:
5483:
5479:
5475:
5471:
5467:
5463:
5459:
5455:
5447:
5440:
5436:
5432:
5427:
5422:
5417:
5412:
5408:
5404:
5403:Critical Care
5400:
5393:
5386:
5381:
5377:
5372:
5367:
5363:
5359:
5355:
5348:
5340:
5336:
5331:
5326:
5322:
5318:
5314:
5310:
5306:
5299:
5297:
5295:
5293:
5284:
5280:
5276:
5272:
5268:
5264:
5263:
5258:
5254:
5247:
5239:
5235:
5230:
5225:
5221:
5217:
5213:
5209:
5205:
5198:
5190:
5186:
5182:
5178:
5174:
5170:
5166:
5159:
5157:
5155:
5135:
5129:
5113:
5109:
5105:
5101:
5094:
5086:
5082:
5078:
5074:
5069:
5064:
5060:
5056:
5049:
5047:
5045:
5043:
5034:
5030:
5025:
5020:
5015:
5010:
5006:
5002:
4998:
4991:
4989:
4980:
4976:
4972:
4968:
4964:
4960:
4953:
4945:
4941:
4936:
4931:
4926:
4921:
4917:
4913:
4909:
4902:
4894:
4890:
4885:
4880:
4876:
4872:
4868:
4864:
4860:
4853:
4851:
4849:
4840:
4836:
4832:
4828:
4824:
4820:
4819:Immunotherapy
4813:
4805:
4801:
4797:
4793:
4789:
4785:
4777:
4769:
4765:
4760:
4755:
4751:
4747:
4743:
4739:
4735:
4728:
4720:
4716:
4711:
4706:
4702:
4698:
4694:
4690:
4686:
4679:
4671:
4667:
4662:
4657:
4653:
4649:
4645:
4641:
4637:
4630:
4623:
4619:
4615:
4611:
4607:
4603:
4599:
4595:
4591:
4587:
4580:
4578:
4569:
4565:
4560:
4555:
4551:
4547:
4543:
4539:
4535:
4528:
4520:
4514:
4510:
4506:
4499:
4497:
4495:
4493:
4491:
4489:
4487:
4478:
4474:
4469:
4464:
4460:
4456:
4452:
4448:
4444:
4437:
4429:
4425:
4420:
4415:
4411:
4407:
4403:
4399:
4395:
4388:
4380:
4378:9780071621670
4374:
4370:
4366:
4359:
4351:
4347:
4342:
4337:
4333:
4329:
4325:
4321:
4317:
4310:
4308:
4306:
4297:
4295:9780323263733
4291:
4287:
4283:
4279:
4275:
4268:
4266:
4264:
4262:
4253:
4249:
4244:
4239:
4235:
4231:
4227:
4223:
4219:
4212:
4210:
4201:
4197:
4192:
4187:
4182:
4177:
4173:
4169:
4165:
4158:
4150:
4146:
4142:
4138:
4133:
4128:
4124:
4120:
4116:
4109:
4102:
4098:
4097:
4091:
4083:
4079:
4075:
4071:
4064:
4062:
4060:
4058:
4056:
4047:
4041:
4037:
4033:
4026:
4024:
4012:
4008:
4004:
4000:
3996:
3992:
3988:
3984:
3980:
3973:
3966:
3964:
3955:
3951:
3946:
3941:
3937:
3933:
3929:
3925:
3921:
3914:
3912:
3903:
3899:
3894:
3889:
3884:
3879:
3875:
3871:
3867:
3863:
3859:
3852:
3850:
3848:
3839:
3835:
3831:
3827:
3823:
3819:
3812:
3804:
3800:
3795:
3790:
3786:
3782:
3778:
3771:
3763:
3759:
3755:
3751:
3747:
3743:
3736:
3728:
3724:
3719:
3714:
3710:
3706:
3702:
3698:
3694:
3687:
3685:
3676:
3672:
3667:
3662:
3658:
3654:
3650:
3646:
3642:
3635:
3633:
3624:
3620:
3616:
3612:
3607:
3602:
3598:
3594:
3590:
3583:
3575:
3571:
3566:
3561:
3557:
3553:
3549:
3542:
3540:
3538:
3536:
3534:
3532:
3530:
3528:
3526:
3524:
3522:
3520:
3518:
3516:
3514:
3512:
3510:
3508:
3506:
3504:
3502:
3500:
3498:
3496:
3494:
3485:
3481:
3476:
3471:
3467:
3463:
3459:
3455:
3451:
3444:
3442:
3440:
3431:
3427:
3422:
3417:
3413:
3409:
3405:
3398:
3396:
3387:
3383:
3378:
3373:
3369:
3365:
3362:(1): 010404.
3361:
3357:
3353:
3346:
3344:
3342:
3340:
3331:
3327:
3322:
3317:
3313:
3309:
3305:
3298:
3296:
3294:
3292:
3290:
3288:
3286:
3284:
3282:
3280:
3278:
3276:
3274:
3272:
3270:
3268:
3266:
3264:
3262:
3260:
3258:
3256:
3254:
3252:
3250:
3248:
3246:
3244:
3242:
3233:
3229:
3224:
3219:
3215:
3211:
3207:
3203:
3199:
3192:
3190:
3188:
3186:
3184:
3182:
3180:
3178:
3169:
3165:
3160:
3155:
3151:
3147:
3143:
3136:
3134:
3125:
3123:9780071484800
3119:
3115:
3111:
3107:
3100:
3098:
3096:
3094:
3092:
3090:
3088:
3086:
3084:
3067:
3063:
3059:
3055:
3049:
3047:
3045:
3043:
3041:
3039:
3037:
3035:
3033:
3031:
3026:
3014:
3010:
3007:
3006:
3000:
2997:
2995:
2991:
2987:
2983:
2979:
2975:
2971:
2967:
2966:Paul E. Marik
2963:
2961:
2957:
2956:
2951:
2950:
2945:
2944:
2943:Lactobacillus
2939:
2938:
2933:
2932:
2927:
2926:
2921:
2920:
2915:
2914:
2909:
2908:
2903:
2902:
2897:
2893:
2889:
2885:
2876:
2867:
2865:
2861:
2859:
2849:
2847:
2843:
2827:
2825:
2821:
2815:
2813:
2808:
2804:
2800:
2795:
2793:
2789:
2785:
2784:
2779:
2775:
2771:
2767:
2763:
2758:
2756:
2752:
2748:
2744:
2740:
2736:
2731:
2729:
2725:
2720:
2718:
2714:
2710:
2702:
2698:
2693:
2684:
2682:
2676:
2674:
2670:
2666:
2662:
2658:
2652:
2650:
2646:
2642:
2636:
2634:
2633:United States
2630:
2620:
2616:
2613:
2608:
2599:
2595:
2593:
2589:
2585:
2581:
2577:
2573:
2569:
2565:
2561:
2557:
2553:
2549:
2548:H2 antagonist
2545:
2541:
2537:
2533:
2529:
2525:
2521:
2516:
2513:
2509:
2504:
2502:
2497:
2493:
2489:
2485:
2481:
2479:
2475:
2470:
2462:
2459:
2450:
2446:
2440:
2432:
2423:
2421:
2420:
2415:
2411:
2407:
2397:
2394:
2390:
2386:
2382:
2378:
2376:
2372:
2368:
2364:
2363:mitochondrial
2360:
2356:
2350:
2348:
2344:
2340:
2336:
2332:
2328:
2320:
2316:
2306:
2303:
2299:
2294:
2290:
2286:
2282:
2278:
2274:
2269:
2266:
2262:
2258:
2248:
2245:
2241:
2237:
2232:
2231:stroke volume
2226:
2224:
2220:
2216:
2206:
2204:
2203:hemoperfusion
2200:
2196:
2192:
2188:
2183:
2179:
2175:
2171:
2167:
2163:
2159:
2149:
2147:
2143:
2139:
2135:
2131:
2129:
2125:
2120:
2116:
2112:
2107:
2097:
2095:
2091:
2086:
2081:
2079:
2075:
2071:
2067:
2063:
2059:
2055:
2051:
2047:
2043:
2039:
2038:
2033:
2029:
2025:
2024:
2018:
2017:
2012:
2011:
2006:
2002:
1997:
1991:
1989:
1985:
1981:
1977:
1973:
1969:
1958:
1956:
1952:
1948:
1944:
1940:
1936:
1932:
1928:
1924:
1920:
1915:
1913:
1909:
1899:
1890:
1888:
1884:
1880:
1876:
1872:
1868:
1858:
1856:
1852:
1848:
1844:
1840:
1836:
1832:
1828:
1824:
1820:
1810:
1808:
1803:
1800:
1796:
1795:procalcitonin
1792:
1782:
1774:
1771:
1768:
1764:
1763:
1761:
1757:
1753:
1749:
1745:
1744:
1742:
1738:
1735:
1732:
1729:
1722:
1719:
1718:
1716:
1712:
1708:
1704:
1701:
1698:
1695:
1694:
1692:
1683:
1680:
1677:
1674:(evidence of
1669:
1661:
1658:
1646:
1645:
1643:
1639:
1635:
1625:
1622:
1618:
1611:
1608:
1605:
1602:
1598:
1594:
1593:
1591:
1588:
1585:
1582:
1581:
1579:
1578:
1577:
1571:
1567:
1563:
1562:heart failure
1559:
1557:
1553:
1549:
1545:
1541:
1538:
1534:
1530:
1526:
1522:
1519:
1515:
1513:
1509:
1497:
1493:
1492:
1491:
1489:
1483:
1473:
1471:
1467:
1463:
1459:
1451:
1447:
1446:
1442:
1439:
1435:
1434:Severe sepsis
1432:
1429:
1426:
1423:
1419:
1415:
1411:
1407:
1403:
1402:
1401:
1393:
1385:
1381:
1379:
1376:
1375:
1371:
1367:
1365:
1362:
1361:
1357:
1355:
1352:
1351:
1347:
1345:
1342:
1341:
1337:
1334:
1333:
1330:
1320:
1318:
1314:
1310:
1306:
1302:
1298:
1294:
1290:
1285:
1283:
1282:point of care
1279:
1275:
1270:
1268:
1264:
1260:
1256:
1252:
1248:
1244:
1240:
1232:
1228:
1224:
1223:Blood culture
1220:
1216:
1214:
1204:
1202:
1198:
1194:
1190:
1186:
1182:
1178:
1173:
1171:
1167:
1163:
1159:
1155:
1152:may activate
1151:
1150:interleukin 6
1147:
1146:interleukin 1
1143:
1139:
1135:
1131:
1127:
1126:heart failure
1123:
1119:
1115:
1111:
1107:
1103:
1099:
1094:
1092:
1088:
1084:
1080:
1076:
1072:
1068:
1064:
1060:
1056:
1052:
1048:
1047:T helper cell
1044:
1040:
1036:
1032:
1022:
1020:
1016:
1012:
1008:
1004:
1003:C-type lectin
1000:
996:
992:
988:
987:peptidoglycan
984:
980:
976:
972:
967:
965:
961:
957:
953:
949:
948:superantigens
945:
941:
937:
936:gram-positive
933:
929:
926:component of
925:
921:
920:gram-negative
917:
913:
909:
899:
897:
893:
889:
885:
881:
877:
866:
862:
860:
859:
854:
853:
848:
844:
843:
838:
835:, a frequent
834:
830:
829:
824:
823:Fungal sepsis
820:
819:
814:
813:
808:
807:
802:
801:
796:
795:staphylococci
792:
788:
784:
780:
776:
772:
764:
760:
756:
752:
748:
744:
740:
736:
732:
728:
723:
714:
712:
707:
703:
699:
695:
691:
688:
686:
682:
678:
673:
671:
667:
663:
659:
655:
651:
647:
643:
639:
635:
631:
627:
623:
619:
606:
588:
586:
582:
576:
574:
571:. The use of
570:
566:
562:
558:
557:stress ulcers
554:
550:
547:
543:
539:
535:
531:
527:
523:
519:
515:
511:
507:
502:
500:
496:
495:heart failure
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
435:urinary tract
431:
429:
425:
421:
417:
414:, high blood
413:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
364:immune system
360:
358:
354:
345:
341:
336:
334:
330:
327:
323:
319:
316:
312:
309:
305:
301:
298:
294:
291:
287:
284:
282:
278:
272:
269:
267:
264:
262:
259:
257:
254:
252:
249:
247:
244:
242:
239:
236:
235:
233:
231:
227:
223:
220:
216:
212:
208:
202:
199:
197:
194:
192:
189:
187:
184:
183:
181:
179:
178:Complications
175:
169:
166:
164:
161:
159:
156:
154:
151:
149:
146:
144:
141:
139:
136:
134:
131:
130:
128:
126:
122:
119:
116:
114:
110:
101:
72:
71:
69:
67:Pronunciation
65:
60:
56:
51:
46:
40:
36:
34:
19:
10713:Döhle bodies
10701:Arneth count
10688:Granulocytes
10551:Anisochromia
10529:Stomatocyte
10440:Microcytosis
10435:Macrocytosis
10430:Anisocytosis
10364:Traumatology
10265:Hemodynamics
10239:SAPS II
10206:Vasopressors
10124:Induced coma
9981:
9972:Iatrogenesis
9962:Stress ulcer
9866:Spinal shock
9823:Septic shock
9812:
9663:
9652:
9641:
9617:
9606:
9591:
9564:
9545:
9521:
9483:
9469:
9419:
9415:
9405:
9375:(1): 77–93.
9372:
9368:
9362:
9329:
9325:
9319:
9274:
9270:
9260:
9248:. Retrieved
9239:
9229:
9194:
9190:
9180:
9147:
9143:
9133:
9121:. Retrieved
9106:
9097:
9075:
9064:
9034:
8983:
8979:
8969:
8924:
8920:
8910:
8897:
8887:
8852:
8848:
8838:
8803:
8799:
8789:
8754:
8750:
8740:
8707:
8703:
8697:
8672:
8668:
8661:
8629:(1): 20–24.
8626:
8622:
8612:
8577:
8573:
8563:
8530:
8526:
8520:
8503:
8497:
8491:
8479:. Retrieved
8465:
8462:"Bacteremia"
8456:
8444:. Retrieved
8440:
8384:
8380:
8374:
8351:
8341:
8311:(12): 2077.
8308:
8304:
8298:
8273:
8269:
8263:
8228:
8224:
8214:
8184:
8173:
8146:
8142:
8132:
8106:
8069:
8063:
8022:
8018:
8012:
7977:
7973:
7963:
7938:
7934:
7927:
7890:
7886:
7876:
7843:
7839:
7833:
7796:
7792:
7782:
7749:
7745:
7739:
7702:
7698:
7688:
7655:
7651:
7645:
7610:
7606:
7558:
7554:
7544:
7507:
7503:
7493:
7456:
7452:
7442:
7407:
7403:
7393:
7360:
7356:
7350:
7315:
7311:
7301:
7276:
7272:
7266:
7233:
7229:
7222:
7205:
7201:
7157:
7153:
7143:
7108:
7104:
7051:(1): 17–60.
7048:
7044:
7000:
6994:
6957:
6953:
6943:
6910:
6906:
6899:
6866:
6862:
6856:
6823:
6819:
6813:
6792:
6782:
6749:
6745:
6700:
6696:
6690:
6655:
6651:
6641:
6616:
6612:
6606:
6571:
6567:
6519:
6515:
6461:
6457:
6407:
6403:
6393:
6358:
6354:
6306:
6302:
6292:
6257:
6253:
6243:
6218:
6214:
6207:
6172:
6168:
6158:
6131:
6127:
6117:
6082:
6078:
6028:
6024:
6014:
5989:
5985:
5978:
5943:
5939:
5929:
5917:. Retrieved
5910:the original
5891:
5889:(May 2014).
5881:
5854:
5850:
5840:
5829:the original
5816:
5812:
5771:
5767:
5761:
5726:
5722:
5712:
5677:
5673:
5641:
5637:
5627:
5590:
5586:
5576:
5543:
5539:
5533:
5500:
5496:
5490:
5457:
5453:
5446:
5438:
5406:
5402:
5392:
5383:
5361:
5357:
5347:
5312:
5308:
5266:
5260:
5246:
5211:
5207:
5197:
5172:
5168:
5141:. Retrieved
5128:
5116:. Retrieved
5093:
5058:
5054:
5004:
5000:
4962:
4958:
4952:
4915:
4911:
4901:
4869:(1): 57–69.
4866:
4862:
4822:
4818:
4812:
4787:
4783:
4776:
4741:
4737:
4727:
4692:
4688:
4678:
4643:
4639:
4629:
4621:
4601:
4597:
4541:
4537:
4527:
4504:
4450:
4446:
4436:
4401:
4397:
4387:
4364:
4358:
4326:(1): 53–58.
4323:
4319:
4281:
4228:(6): 29426.
4225:
4221:
4174:(1): 41–52.
4171:
4167:
4157:
4125:(1): 48–79.
4122:
4118:
4108:
4094:
4090:
4076:(1): 44–53.
4073:
4069:
4034:. New York:
4031:
3982:
3978:
3927:
3923:
3883:11343/273829
3865:
3861:
3821:
3817:
3811:
3784:
3780:
3770:
3745:
3741:
3735:
3700:
3696:
3648:
3644:
3596:
3592:
3582:
3555:
3551:
3457:
3453:
3411:
3407:
3359:
3355:
3311:
3307:
3205:
3201:
3149:
3145:
3109:
3070:. Retrieved
3057:
2998:
2964:
2953:
2947:
2941:
2935:
2929:
2923:
2917:
2911:
2905:
2899:
2881:
2862:
2855:
2838:
2824:drug targets
2816:
2802:
2796:
2781:
2759:
2732:
2721:
2706:
2696:
2677:
2669:major trauma
2653:
2637:
2626:
2623:Epidemiology
2617:
2609:
2605:
2596:
2580:erythromycin
2556:feeding tube
2517:
2505:
2482:
2471:
2468:
2456:
2447:
2429:
2417:
2403:
2379:
2351:
2315:tidal volume
2312:
2289:pancreatitis
2285:septic shock
2270:
2254:
2227:
2219:vasopressors
2212:
2209:Vasopressors
2195:antithrombin
2155:
2132:
2103:
2082:
2070:itraconazole
2050:echinocandin
2035:
2022:
2014:
2008:
1992:
1964:
1923:hemodialysis
1916:
1904:
1864:
1816:
1804:
1788:
1780:
1765:total serum
1733:(INR) > 2
1603:> 5 mEq/L
1601:base deficit
1595:unexplained
1575:
1486:Examples of
1485:
1455:
1445:Septic shock
1443:
1433:
1427:
1398:
1286:
1271:
1236:
1210:
1181:nitric oxide
1174:
1095:
1075:CD4+ T cells
1028:
1025:Host factors
968:
946:that act as
942:. Bacterial
914:and various
905:
892:pancreatitis
872:
863:
858:Echinococcus
856:
850:
840:
826:
816:
810:
804:
798:
768:
755:Hemodialysis
747:pain killers
692:
689:
685:septic shock
674:
615:
577:
567:levels with
503:
451:major trauma
437:, skin, and
432:
424:Septic shock
361:
352:
351:
326:vasopressors
251:major trauma
230:Risk factors
39:
32:
10809:Neonatology
10671:Smudge cell
10658:Lymphocytes
10597:Cabot rings
10510:Schistocyte
10474:Elliptocyte
10464:Acanthocyte
10347:Pulmonology
10270:Hypotension
10165:Antibiotics
10008:Dialytrauma
9851:Anaphylaxis
9643:MedlinePlus
9522:MedlinePlus
9302:10831/67370
9277:: 135–141.
9123:24 February
8481:25 November
8074:McGraw-Hill
7459:(6): R289.
6960:(17): 330.
6793:ardsnet.org
6744:Medicine".
6025:Circulation
5729:(1): 4–11.
5118:26 February
4646:(12): e66.
4369:McGraw-Hill
4036:McGraw-Hill
3824:: 116–130.
3460:(10): 782.
3114:McGraw-Hill
3072:28 November
2949:Bacteroides
2937:Clostridium
2896:decomposers
2884:mutualistic
2641:U.S. states
2584:QT interval
2576:domperidone
2562:. However,
2484:Recombinant
2327:ventilation
2300:nor random
2255:The use of
2066:fluconazole
2054:caspofungin
2032:teicoplanin
1961:Antibiotics
1919:antibiotics
1843:anaphylaxis
1799:sensitivity
1676:hypercapnic
1587:vasopressor
1358:>90/min
1344:Temperature
1323:Definitions
1301:chest X-ray
1189:vasopressin
1166:blood clots
1067:macrophages
1059:Neutrophils
852:Schistosoma
831:species of
773:but may be
739:antibiotics
702:hemodynamic
585:Hippocrates
565:blood sugar
483:anaphylaxis
210:Usual onset
163:severe pain
18:Septicaemia
10778:Categories
10743:Left shift
10625:Haemoconia
10607:Heinz body
10505:Echinocyte
10486:Spherocyte
10406:Blood film
10354:Pediatrics
10337:Cardiology
10258:Physiology
10160:Analgesics
10109:Chest tube
9938:/ myopathy
9915:Polytrauma
9791:Conditions
9654:Patient UK
9619:DiseasesDB
9240:sepsis.org
9236:"About Us"
8446:6 February
7893:(1): 239.
7799:(1): 109.
7510:(3): 222.
7095:Rivers E,
6410:(5): 532.
5919:6 December
5593:(1): R15.
5546:(1): 2–8.
5409:(1): 210.
4918:(24): 24.
3021:References
2931:Klebsiella
2888:microbiome
2820:biomarkers
2735:bacteremia
2697:septicemia
2546:(PPI) and
2486:activated
2371:intubation
2309:Anesthesia
2291:or severe
2244:Dobutamine
2162:hemoglobin
2058:micafungin
2052:, such as
2037:Legionella
2028:vancomycin
1984:macrolides
1976:carbapenem
1908:Sepsis Six
1893:Management
1875:meningitis
1785:Biomarkers
1752:creatinine
1748:creatinine
1619:prolonged
1462:SOFA score
1410:heart rate
1354:Heart rate
1039:leukocytes
1009:, and the
912:glycocalyx
910:, such as
906:Bacterial
888:polytrauma
842:Plasmodium
818:Klebsiella
296:Prevention
10515:Degmacyte
10500:Dacrocyte
10342:Neurology
10195:Sedatives
10175:Inotropes
10021:Diagnosis
9488:is being
9397:235215735
9354:195788169
9250:8 October
9221:238257608
9103:"History"
8781:204758015
8389:CiteSeerX
7793:Crit Care
7258:207311061
6799:(NHLBI),
6260:: g4561.
5723:Virulence
5385:patients.
5063:CiteSeerX
4689:Virulence
4447:Virulence
4398:Virulence
4278:Blaser MJ
3623:227067133
2974:vitamin C
2852:Education
2835:Economics
2812:cytoplasm
2778:endotoxin
2766:mammalian
2663:, or the
2639:study of
2612:APACHE II
2602:Prognosis
2496:APACHE II
2488:protein C
2367:etomidate
2359:apoptosis
2313:A target
2293:pneumonia
2197:to treat
2170:hypoxemia
2124:inotropes
2042:macrolide
1879:pneumonia
1767:bilirubin
1628:> 3 °C
1537:bilirubin
1533:bilirubin
1418:blood gas
1309:petechiae
1305:pneumonia
1227:anaerobes
1207:Diagnosis
1199:known as
1136:. In the
1128:. In the
1110:bile salt
1063:monocytes
1055:apoptosis
979:flagellin
964:cytokines
944:exotoxins
932:endotoxin
821:species.
779:parasitic
771:bacterial
711:IV fluids
664:, higher
634:confusion
384:pneumonia
380:confusion
357:infection
343:Frequency
333:Prognosis
314:Treatment
168:confusion
113:Specialty
10759:Auer rod
10635:Rouleaux
10469:Codocyte
10408:findings
10033:Catheter
9952:Fungemia
9727:Medicine
9518:"Sepsis"
9508:Archived
9481:template
9446:34478032
9389:34039089
9346:31268477
9311:28899789
9244:Archived
9213:34605781
9172:52827184
9164:28098591
9117:Archived
9089:24455786
9056:Archived
9052:27359025
9012:27672669
8961:23401516
8902:Archived
8879:27352632
8830:27305321
8773:31661479
8689:10087992
8653:34569641
8604:16562068
8547:30106029
8475:Archived
8419:24332955
8411:18171697
8333:37084190
8325:17131165
8290:25054718
8255:21805196
8206:Archived
8202:24901179
8165:12700374
8124:Archived
8120:24228290
8047:24797961
8004:19864995
7955:19427752
7919:32430052
7868:37895257
7860:25635594
7825:36915173
7816:10012592
7774:51599526
7766:29984680
7731:19725146
7680:20904332
7672:25190187
7637:23235609
7585:22972094
7536:21672276
7485:24326145
7434:28221185
7385:18089789
7377:12831416
7342:23481106
7293:24140138
7250:25982917
7214:26091011
7184:22517402
7127:11794169
7097:Nguyen B
7075:18058085
6986:27713888
6935:22739840
6927:25255427
6883:22971586
6840:22488264
6805:Archived
6766:18496365
6725:54537066
6717:30522935
6682:26100123
6633:21680949
6598:29340539
6536:28509668
6498:26237037
6458:PLOS ONE
6436:25277635
6385:24043371
6333:16280618
6325:25270275
6284:25099709
6235:24262273
6199:23418281
6175:: f839.
6150:23423413
6109:30073665
6055:26473000
6006:26974879
5970:26121073
5873:21398303
5825:23427506
5788:28477737
5774:: 1–12.
5753:24335434
5704:22706919
5619:20144219
5560:15636651
5525:12657048
5517:17948334
5474:29404582
5435:27423462
5380:26927525
5339:22783783
5238:29158243
5189:23375419
5143:23 March
5112:Archived
5085:24889440
5033:25110606
4979:12848314
4944:29259697
4893:25567335
4839:21174562
4804:23590272
4768:16020688
4719:23974910
4670:24310172
4568:24977655
4477:24157707
4428:24193365
4350:28416934
4280:(eds.).
4252:26653692
4200:20606908
4149:53036546
4141:30348463
4082:23939605
4011:Archived
4007:19605781
3999:12682500
3954:22734959
3902:31954465
3838:27450868
3803:27054476
3762:28916121
3727:30575845
3675:31808551
3615:33208389
3574:23353941
3484:31611560
3430:23984731
3386:23198133
3330:28101605
3232:26903338
3168:24745331
3146:Immunity
3066:Archived
3003:See also
2978:thiamine
2892:adaptive
2870:Research
2842:Medicaid
2774:Pfeiffer
2762:microbes
2751:fungemia
2739:bacteria
2717:purulent
2713:Avicenna
2661:diabetes
2649:Medicare
2590:such as
2570:such as
2530:(LMWH),
2510:levels,
2501:eritoran
2453:Newborns
2412:from an
2305:needed.
2302:cortisol
2257:steroids
2251:Steroids
2236:Dopamine
2180:events.
2062:triazole
2026:(MRSA),
1996:hospital
1721:platelet
1570:troponin
1542:Kidney:
1498:(ARDS) (
1187:such as
1179:such as
1114:jaundice
1031:antigens
916:adhesins
530:dialysis
447:diabetes
304:vaccines
288:(SIRS),
246:diabetes
125:Symptoms
10359:Surgery
9668:Q183134
9664:Scholia
9613:D018805
9437:8413356
9279:Bibcode
9003:5030723
8952:3587220
8929:Bibcode
8870:5365153
8821:4960474
8732:9851930
8712:Bibcode
8704:Science
8645:6985638
8555:4352586
8246:3303037
8055:5089865
8027:Bibcode
7995:3776422
7910:7236499
7722:2738808
7628:6464614
7576:6517277
7527:3218963
7476:4057370
7425:5389594
7333:4405627
7175:3608508
7135:7549555
7066:2249616
6977:5050189
6848:6406983
6803:(NIH).
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