363:
only sugar that S.mutans are capable of using to produce the polyacrylamide adhesive which allows them to bind to the teeth. Xylitol does not actively reduce or harm the presence or capacities of oral bacteria, but rather does not offer them the sustenance to propagate or function. There are often claims of significant dental benefits of
Xylitol. These generally derive from the perspectives of; saliva production is increased during chewing and oral stimulation which can help to maintain a more adequate supply of saliva to support normal oral functioning. Also, because Xylitol is a sweetener option which does not serve as fuel for oral bacteria it is considered to be the healthier alternative than sucrose (table sugar), fructose, lactose, galactose products. While these considerations may not reverse any conditions in health, they are more preventative, and do not further the consequential events such as dental caries, malodorous breath, excessive plaque and gingivitis conditions.
246:. Fluoride interferes with the process of tooth decay as fluoride intake during the period of enamel development for up to 7 years of age; the fluoride alters the structure of the developing enamel making it more resistant to acid attack. In children and adults when teeth are subjected to the alternating stages of demineralisation and remineralization, the presence of fluoride intake encourages remineralization and ensures that the enamel crystals that are laid down are of improved quality. Fluoride is commonly found in toothpastes. Fluoride can be delivered to many parts of the oral cavity during brushing, including the tooth surface, saliva, soft tissues and remaining plaque biofilm. Some remineralization methods may work for "white spot lesions" but not necessarily "intact tooth surfaces".
20:
339:
sugar intake at which caries progresses to cavitation. It has been concluded in modern societies that a significant relationship between sugars and caries persists despite the regular widespread use of fluoride toothpaste. Several reviews conclude that high sugar consumption continues to be the main threat for dental health of whole populations in some developed and many developing countries. Therefore, a key strategy to further reducing levels of caries in individuals as well as for populations, is by means of reducing the frequency of sugar intakes in the diet.
422:
peptide scaffold mimicking the enamel matrix. Around the newly formed matrix de-novo enamel-crystals are formed from calcium phosphate present in saliva. Through the remineralization caries activity is significantly reduced in comparison with a fluoride treatment alone. In aqueous oral care gels the peptide is present as matrix. It binds directly as matrix to the tooth mineral and forms a stable layer on the teeth. This layer does protect the teeth from acid attacks. It also occludes open dentin tubule and thus reduces the dental sensitivity.
347:
seeds and nuts. Sugary snacks including lollies, fruit bars, muesli bars, biscuits, dried fruit, cordials, juices and soft drinks should be limited as they contribute to dental decay and dental erosion. Additionally, excessive starchy foods (such as bread, pasta, and crackers), fruits and milk products consumed frequently can cause the growth of dental plaque and bacteria. Therefore, a diet low in sugar and proper maintenance of oral hygiene is the best way to promote and maintain sound tooth structure for an individual.
150:
surrounding the enamel, thereby inhibiting caries progression. Plaque thickness and the number of bacteria present determine the effectiveness of salivary buffers. The high salivary concentrations of calcium and phosphate which are maintained by salivary proteins may account for the development and remineralization of enamel. The presence of fluoride in saliva speeds up crystal precipitation forming a fluorapatite-like coating which will be more resistant to caries.
288:. There are many types of fluoride varnishes and among them the popular brands are Duraphat and Fluor Protector. Currently, the anti-caries effect fluoride varnishes are backed up by Cochrane systematic reviews, 2002 which was updated in 2013 included 22 trials with 12,455 children aged 1â15 years old. The conclusion made is similar to its previous review, a 46% reduction in D(M)FS and 33% reduction in d (e/m)fs in permanent teeth and deciduous teeth respectively
280:
overcome their shortcoming which is to prolong the contact time between fluoride and tooth surfaces. Furthermore, when compared to other existing topical fluoride the advantages of fluoride varnishes application are being a quick and easy procedure for the clinicians, reduced discomfort for the receiving patients, and greater acceptability by the patients. Fluoride varnishes are a concentrated topical fluoride containing 5%
331:
remineralization to occur naturally. A loss of the tooth enamel structure and cavitation may occur if the demineralization phase continues for a long period of time. This disturbance of demineralisation caused by the presence of fermentable carbohydrates continues until the saliva has returned to a normal pH and had sufficient time to penetrate and neutralize the acids within any cariogenic biofilm present.
434:
359:
been found to reduce mutans streptococci in plaque and saliva and reduce the binding of these to the acquired enamel pellicle. This in turn leads to less adherent plaque and a decrease in acid production. In addition, chewing xylitol gum will stimulate increased salivary flow which in turn increases the amount of calcium in the saliva and enhances the oral clearance.
237:
lot longer and making them easier to prevent via normal brushing as it will take a higher amount of acid, usually built up over a number of days, to destroy the created fluorapatite. When fluoride ions are present in plaque fluid along with dissolved hydroxyapatite, and the pH is higher than 4.5, a fluorapatite-like remineralised
343:
mouth. The bacteria produce acid, which destroys teeth. Highly refined packaged foods such as savory crackers and chips can also have high levels of carbohydrates. It is important to check the nutritional information panel on packaged foods to determine which foods and drinks have high carbohydrate concentrations.
362:
Additional saliva flow which includes chewing products such as gums that contain no fermentable carbohydrates can aid in the modulation of plaque pH. Xylitol is a sugar alcohol which provides the sensation of tasting sweetness in foods, particularly chewing gum, without providing sucrose which is the
241:
is formed over the remaining surface of the enamel; this veneer is much more acid-resistant than the original hydroxyapatite, and is formed more quickly than ordinary remineralised enamel would be. The cavity-prevention effect of fluoride is partly due to these surface effects, which occur during and
125:
Remineralization occurs on a daily basis after attack by acids from food, through the presence of calcium, phosphate and fluoride found in saliva. Saliva also acts as a natural buffer to neutralize acid, preventing demineralization in the first place. If there is reduced saliva flow or reduced saliva
342:
Foods high in refined carbohydrates, such as concentrated fruit snack bars, sweets, muesli bars, sweet biscuits, some breakfast cereals and sugary drinks including juices can contribute to dental decay, especially if eaten often and over long periods as the sugar nourishes the cariogenic bacteria in
338:
Recent studies on diet and caries have been confounded by the widespread use of fluoride toothpastes. Studies have argued that with greater exposure to fluoride, the sugar consumption/caries relationship may be weaker in the modern age than previously thought, with fluoride raising the threshold of
321:
Oral hygiene practices involve the mechanical removal of plaque from hard tissue surfaces
Cariogenic bacteria levels in the plaque determine whether caries will occur or not, therefore, effective removal of plaque is paramount. The removal of plaque inhibits demineralisation of teeth, and increases
279:
Fluoride varnishes were developed late 1960s and early 1970s and since then they have been used both as a preventative agent in public health programs and as a specific treatment for patients at risk of caries by the 1980s, mostly in
European countries. Fluoride varnishes were developed primarily to
236:
or surface effect. A person living in an area with fluoridated water may experience rises of fluoride concentration in saliva to about 0.04 mg/L several times during a day. Technically, this fluoride does not prevent cavities but rather controls the rate at which they develop making them take a
79:
whilst tooth wear is caused by acids from non-bacterial sources. These can be extrinsic in source, such as carbonated drinks, or intrinsic acids, usually from stomach acid coming into the mouth. Both types of demineralization will progress if the acid attacks continue unless arrested or reversed by
773:
Over sixty years of research shows that water fluoridation helps to prevent tooth decay by protecting against damage and helping with the repair of teeth. All of the studies in previous reviews and in the 2016 NHMRC Evidence
Evaluation found that water fluoridation reduces tooth decay by 26-44% in
421:
Self assembling properties of P11-4 are used to regenerate early caries lesions. By application of P11-4 on the tooth surface, the peptide diffuse through the intact hypomineralized plate into the early caries lesion body and start, due to the low pH in such a lesion, to self-assemble generating a
358:
is a naturally-occurring sweetener that can be synthetically produced in bulk. It is classified as a sugar alcohol. Xylitol inhibits acid production by oral bacteria and promotes remineralization of the teeth. It can be found in various products which include chewing gums and lozenges. Xylitol has
346:
To prevent demineralisation in the mouth, it is important for an individual to ensure they have a well-balanced diet, including foods containing calcium and foods that are low in acids and sugars. The individual should have a diet high in fresh fruits and vegetables, wholegrain cereals, legumes,
334:
Increased sugar consumption in the means of foods and drinks containing high levels of sugar are known to be associated with high rates of dental decay. As a result, members of the dental team routinely assess patients' diets and highlight areas where this could be improved to reduce the risk of
798:
There is evidence that water fluoridation at current
Australian levels is not associated with cognitive dysfunction, lowered IQ, cancer, hip fracture and Down syndrome. There is no reliable evidence of an association between water fluoridation at current Australian levels and other human health
417:
P11-4 is a self-assembling β-peptide. It builds a 3-D bio-matrix with binding sites for
Calcium-ions serving as nucleation point for hydroxyapatite (tooth mineral) formation. The high affinity to tooth mineral is based on matching distances of Ca-ion binding sites on P11-4 and Ca spacing in the
330:
Demineralization is caused by bacteria excreting acids as a product of their metabolism of carbohydrates. By reducing the intake frequency of carbohydrates in an individual's diet, remineralization is increased and demineralization is decreased. Diet control is an important aspect in promoting
149:
As the demineralization process continues, the pH of the mouth becomes more acidic which promotes the development of cavities. Dissolved minerals then diffuse out of the tooth structure and into the saliva surrounding the tooth. The buffering capacity of saliva greatly impacts the pH of plaque
335:
dental decay. A balanced diet is an important contributing factor towards oral health and general health. It is common knowledge that certain dietary habits contribute to disease, whether patients take note of advice which is given to them and change their diet as a result, is less certain.
111:
However, the capacity for remineralization is limited, and if sugars enter the mouth too frequently then a net loss of minerals from enamel produces a cavity, through which bacteria can infect the inner tooth and destroy the latticework. This process requires many months or years.
399:, providing new sites for mineralisation to occur. Their binding to the teeth also occludes open dentin tubules, helping to reduce dentin hypersensitivity. Evidence is insufficient to recommend either for any indications, but the evidence for CSPS is stronger than that for ACP.
270:
As stated previously, fluoride has been proven to positively affect the remineralization process through fluorapatite-like veneer formation. Therefore, by using an adequately fluoridated toothpaste regularly, this assists the remineralization process of any hard tooth tissues.
308:
statutory body, released the public statement of efficacy and safety of fluoridation 2007 to set the recommended water fluoridation to the target range of 0.6 to 1.1 mg/L, depending on climate, to balance reduction of dental caries (tooth decay) and occurrence of
108:. The plaque can hold the acids in contact with the tooth for up to two hours, before it is neutralized by saliva. Once the plaque acid has been neutralized, the minerals can return from the plaque and saliva to the enamel surface.
609:
Hicks J, Garcia-Godoy F, Flaitz C. Biological factors in dental caries: role of saliva and dental plaque in the dynamic process of demineralization and remineralization (part 1). Journal of
Clinical Pediatric Dentistry. 2004 Sep
313:(mottling of teeth). Moreover the public statement states that the fluoridation of drinking water is an effective way to ensure the community is exposed to fluoride and can benefit from its preventative role in tooth decay.
413:
P11-4 (Ace-QQRFEWEFEQQ-NH2, Curolox) is a synthetic, pH controlled self-assembling peptide used for biomimetic mineralization e.g. for enamel regeneration or as an oral care agent. It has a high affinity to tooth mineral.
254:
Regular use of a fluoridated toothpaste has been shown to provide a significant source of fluoride to the mouth by the means of direct fluoride contact to tooth structure. The types of fluoride added to toothpaste include:
1052:
BeltrĂĄn-Aguilar; Goldstein; Lockwood (2000). "Fluoride
Varnishes: A Review of Their Clinical Use, Cariostatic Mechanism, Efficacy and Safety: A Review of Their Clinical Use, Cariostatic Mechanism, Efficacy and Safety".
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Hicks, John; Garcia-Godoy, Franklin; Flaitz, Catherine (2003-01-01). "Biological factors in dental caries: role of saliva and dental plaque in the dynamic process of demineralization and remineralization (part 1)".
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GarcĂa-Godoy, Franklin; Hicks, M. John (2008-05-01). "Maintaining the integrity of the enamel surface: The role of dental biofilm, saliva and preventive agents in enamel demineralization and remineralization".
88:
When food or drinks containing fermentable sugars enter the mouth, the bacteria in dental plaque rapidly feed on the sugars and produce organic acids as by-products. The glucose produced from starch by
619:
Fejerskov O, Nyvad B, Kidd EA: Pathology of dental caries; in
Fejerskov O, Kidd EAM (eds): Dental caries: The disease and its clinical management. Oxford, Blackwell Munksgaard, 2008, vol 2, pp 20-48.
1782:
300:
is the addition of fluoride in the drinking water with the aim of reducing tooth decay by adjusting the natural fluoride concentration of water to that recommended for improving oral health. The
75:. It begins at the surface, and may progress into either cavitation (tooth decay) or erosion (tooth wear). Tooth decay demineralization is caused by acids from bacteria in the dental plaque
543:
Cochrane NJ, Cai F, Huq NL, Burrow MF, Reynolds EC. New approaches to enhanced remineralization of tooth enamel. Journal of Dental
Research. 2010 Nov 1;89(11):1187-97.
199:
Provides an overall community advantage, especially individuals from low socioeconomic communities, who have less access to other forms of fluoride treatments
1731:"Dentine Tubule Occlusion of a Novel Self-n Vitro Evaluation of Dentine Remineralization by a Self-Assembling Peptide Using Scanning Electron Microscopy"
395:(ACP, Recaldent), are used in some toothpastes and topical preparations to promote remineralization of teeth. These particles have a structure mimicking
1639:
Aggeli, A; Bell, M; et al. (20 March 1997). "Responsive gels formed by the spontaneous self-assembly of peptides into polymeric β-sheet tapes".
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Dr RS Levine. "The British Fluoridation Society", A guide to the action of fluoride in the prevention of dental decay, 2016. retrieved on 2016-05-3.
1775:"Diffusion of Ions Between Two Solutions Saturated With Respect to Hydroxyapatite: A Possible Mechanism for Subsurface Demineralization of Teeth"
126:
quality, this will increase the risk of demineralization and create the need for treatment in order to prevent demineralization progression.
1191:
Arathi Rao, Neeraj Malhotra. "The Role of Remineralizing Agents in dentistry: A Review". Volume 32, Number 6. 2011. retrieved on 2016-05-22.
301:
129:
Saliva function can be organized into five major categories that serve to maintain oral health and create an appropriate ecologic balance:
418:
crystal lattice of hydroxyapatite. The matrix formation is pH controlled and thus allows control matrix activity and place of formation.
534:
Fejerskov, O., Nyvad, Bente, & Kidd, Edwina A. M. (2015). Dental caries: The disease and its clinical management (Third ed.),
23:
Example: Demineralization and remineralization of dental enamel in the presence of acid and fluoride in saliva and plaque fluid.
600:
Garcia- Godoy, F. & Hicks, J. (2008). Maintaining the integrity of the enamel surface. American Dental Association, 139(3).
566:
Li, Xiaoke; Wang, Jinfang; Joiner, Andrew; Chang, Jiang (2014). "The remineralization of enamel: a review of the literature".
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The presence of fluoride in saliva and plaque fluid interacts with remineralization process in many ways and thus exerts a
1129:
National health and medical research council. "Health effects of water fluoridation", 2016-04-06. retrieved on 2016-04-11.
189:
Helps prevent premature tooth loss of baby teeth due to decay and overall assists in guiding the adult teeth to correct
457:
905:
Cury, J. A.; Tenuta, L. M. A. (2008). "How to Maintain a Cariostatic Fluoride Concentration in the Oral Environment".
628:
Soi S, Roy AS, Vinayak V. Fluorides and Their Role in Demineralization and Remineralization. Principalâs Message.:19.
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Aids in the prevention of invasive dental treatment therefore reducing the amount of money spent on dental treatment
382:
1089:
1400:"The Effect of Calcium Sodium Phosphosilicate on Dentin Hypersensitivity: A Systematic Review and Meta-Analysis"
388:
1090:"Effect of sodium, amine and stannous fluoride at the same concentration and different pH on in vitro erosion"
1830:
998:
Iijima, Y. (2008). "Early detection of white spot lesions with digital camera and remineralization therapy".
1692:"Efficacy, Clinical Applicability and Safety, of CurodontTM Repair in Children with Early Occlusal Caries"
202:
Evidence confirms that water fluoridation is a safe and effective way to help protect teeth against decay
178:
Potentially repairing early white spot lesions found on the tooth surface that may develop into cavities.
1596:
Kirkham, J; et al. (May 2007). "Self-assembling Peptide Scaffolds Promote Enamel Remineralization".
392:
1549:"Treatment of early caries lesions using biomimetic self-assembling-peptides â a clinical safety trial"
260:
745:. Canberra, Australia: Australian Government National Health and Medical Research Council. July 2017.
1202:
60:. Remineralization can contribute towards restoring strength and function within tooth structure.
373:. However, this research is industry funded and not as comprehensive as the research on xylitol.
1774:
53:
1459:"Dentine hypersensitivity: bleaching and restorative considerations for successful management"
1138:
Darby ML, Walsh M. Dental hygiene: theory and practice. Elsevier Health Sciences; 2014 Apr 15.
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is often used to promote remineralization. This produces the stronger and more acid-resistant
205:
The addition of fluoride to the water does not alter the taste or smell of the drinking water
305:
158:
Besides professional dental care, there are other ways for promoting tooth remineralization:
1648:
1411:
63:
Demineralization is the removal of minerals (mainly calcium) from any of the hard tissues:
1346:"Erythritol Is More Effective Than Xylitol and Sorbitol in Managing Oral Health Endpoints"
8:
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Better health channel. "Dental care - fluoride", April 2012. retrieved on 2016-04-15.
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517:
512:
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220:. Both materials are made of calcium. In fluorapatite, fluoride takes the place of a
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is a mineral found naturally in rock, air, soil, plants and water and may assist by:
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19:
1500:"Casein phosphopeptide-amorphous calcium phosphate products in caries prevention"
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694:"Contemporary perspective on the use of fluoride products in caries prevention"
396:
285:
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217:
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101:
840:
742:
Information Paper â Water fluoridation: dental and other human health outcomes
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And a reduction in cavities may result in the following downstream benefits:
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26:
Remineralization is a natural process and does not have to involve fluoride.
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is also digested by the bacteria. When enough acid is produced so that the
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57:
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1783:
Journal of Research of the National Institute of Standards and Technology
34:
1498:
Hani, Thikrayat Bani; O'Connell, Anne C.; Duane, Brett (24 June 2016).
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822:"Community Water Fluoridation and Caries Prevention: A Critical Review"
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38:
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Zhu, M; Li, J; Chen, B; Mei, L; Yao, L; Tian, J; Li, H (2015).
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1790:(4). National Institute of Science and Technology: 217â224.
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Biomimetic glass and ceramic particles, including amorphous
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819:
49:
1203:"Diet, nutrition and the prevention of dental diseases"
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94:
1497:
16:
Natural repair process for non-cavitated tooth lesions
1200:
429:
383:
Biomimetic material § Biomimetic mineralization
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may have greater protective action than xylitol and
350:
186:Protecting children and adults against tooth decay
1254:"Evidence-based recommendation on toothpaste use"
659:
565:
115:
1822:
376:
284:(NaF) except the Fluor protector which contains
33:is the natural repair process for non-cavitated
1393:
1391:
872:Critical Reviews in Oral Biology & Medicine
1304:The Journal of the American Dental Association
1055:The Journal of the American Dental Association
663:The Journal of the American Dental Association
489:
487:
485:
483:
1547:Brunton, P.A.; Davies, R.P.W. (2 July 2013).
1546:
1201:Moynihan, Paula; Erik Petersen, Poul (2004).
947:
869:
1397:
1388:
1297:"Eating habits for a healthy smile and body"
735:
733:
731:
729:
493:
1456:
1151:The Journal of Clinical Pediatric Dentistry
480:
153:
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1251:
904:
496:"Dental caries: A dynamic disease process"
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249:
1690:Alkilzy, M; et al. (May 15, 2015).
691:
18:
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637:Nanci, A., & Ten Cate, A. (2008).
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83:
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813:
655:
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651:
649:
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402:
291:
227:
1772:
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898:
322:opportunities for remineralization.
56:into crystal voids in demineralised
1163:10.17796/jcpd.28.1.yg6m443046k50u20
948:Hellwig, E.; Lennon, Ă. M. (2004).
274:
166:
97:goes below 5.5, the acid dissolves
13:
1766:
1476:10.1002/j.1875-595x.2002.tb00937.x
1350:International Journal of Dentistry
1286:
1252:Cury, J; Tenuta, L (24 Jan 2014).
1036:
950:"Systemic versus Topical Fluoride"
644:
14:
1842:
1729:Chen, X; et al. (Sep 2014).
1344:de Cock, Peter (21 August 2016).
641:. St. Louis, Mo.: Mosby Elsevier.
351:Xylitol, Sorbitol, and Erythritol
316:
120:
1012:10.1111/j.1834-7819.2008.00062.x
513:10.1111/j.1834-7819.2008.00064.x
432:
1722:
1683:
1632:
1589:
1540:
1491:
1450:
1337:
1316:10.14219/jada.archive.2010.0115
1271:10.1590/S1806-83242014.50000001
1245:
1194:
1185:
1141:
1132:
1123:
1081:
1067:10.14219/jada.archive.2000.0232
991:
982:
941:
863:
804:
786:target range of 0.6 to 1.1 mg/L
774:children, teenagers and adults.
685:
671:10.14219/jada.archive.2008.0352
494:Featherstone, J. D. B. (2008).
665:. 139, Supplement 2: 25Sâ34S.
631:
622:
613:
603:
594:
537:
528:
389:calcium sodium phosphosilicate
139:Maintenance of tooth integrity
136:Buffering action and clearance
116:Natural tooth remineralization
1:
580:10.1016/s0300-5712(14)50003-6
473:
377:Biomimetic glass and ceramics
1463:International Dental Journal
1425:10.1371/journal.pone.0140176
829:Clinical Oral Investigations
7:
1109:10.1016/j.jdent.2009.03.020
907:Advances in Dental Research
425:
393:amorphous calcium phosphate
161:
10:
1847:
1610:10.1177/154405910708600507
1310:(12): 1544. JanâFeb 2011.
919:10.1177/154407370802000104
884:10.1177/154411130201300206
406:
380:
261:sodium monofluorophosphate
216:, rather than the natural
133:Lubrication and protection
1000:Australian Dental Journal
841:10.1007/s00784-007-0111-6
792:
639:Ten Cate's oral histology
500:Australian Dental Journal
1504:Evidence-Based Dentistry
780:
767:
692:Ten Cate, J. M. (2013).
154:Treatment and prevention
104:, the main component of
1565:10.1038/sj.bdj.2013.741
1457:Van Haywood, B (2002).
1258:Brazilian Oral Research
1210:Public Health Nutrition
711:10.1038/sj.bdj.2013.162
325:
1517:10.1038/sj.ebd.6401168
698:British Dental Journal
250:Fluoridated toothpaste
142:Antibacterial activity
31:Tooth remineralization
27:
796:
784:
771:
381:Further information:
306:Australian Government
22:
1831:Dentistry procedures
1796:10.6028/jres.115.015
1363:10.1155/2016/9868421
1097:Journal of Dentistry
568:Journal of Dentistry
391:(CSPS, NovaMin) and
145:Taste and digestion.
1653:1997Natur.386..259A
1416:2015PLoSO..1040176Z
84:Tooth decay process
1223:10.1079/PHN2003589
409:Oligopeptide P11-4
403:Oligopeptide P11-4
298:water fluoridation
292:Water fluoridation
228:Effect of fluoride
80:remineralization.
28:
1773:Chow, L. (2010).
1748:10.1159/000360836
1708:10.1159/000381323
1647:(6622): 259â262.
967:10.1159/000077764
752:978-1-925129-83-0
458:Tooth development
453:Calcium phosphate
265:stannous fluoride
1838:
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275:Fluoride varnish
210:Fluoride therapy
167:Fluoride therapy
91:salivary amylase
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317:Plaque control
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574:: S12âS20.
263:(MFP), and
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1735:Caries Res
1696:Caries Res
1598:J Dent Res
1559:(E6): E6.
758:4 December
474:References
463:Toothpaste
367:Erythritol
296:Community
99:carbonated
1553:Br Dent J
1171:1053-4628
799:outcomes.
222:hydroxide
54:deposited
43:phosphate
1825:Category
1814:21037801
1716:79016534
1626:21582771
1618:17452562
1583:23969679
1534:10479902
1526:27339237
1485:72558772
1444:26544035
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1324:21119136
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857:13189520
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720:23429124
679:18460677
588:24993850
522:18782377
426:See also
371:sorbitol
172:Fluoride
162:Fluoride
73:cementum
47:fluoride
1805:2966276
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1677:4343341
1669:9069283
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234:topical
77:biofilm
69:dentine
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1641:Nature
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239:veneer
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58:enamel
1778:(PDF)
1712:S2CID
1673:S2CID
1622:S2CID
1530:S2CID
1481:S2CID
1300:(PDF)
1206:(PDF)
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853:S2CID
825:(PDF)
302:NHMRC
1810:PMID
1756:2015
1665:PMID
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1522:PMID
1440:PMID
1378:PMID
1354:2016
1331:2016
1320:PMID
1276:PMID
1239:2016
1228:PMID
1175:PMID
1167:ISSN
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888:PMID
845:PMID
760:2021
747:ISBN
716:PMID
675:PMID
584:PMID
518:PMID
326:Diet
52:are
50:ions
1800:PMC
1792:doi
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