444:
421:
690:
42:
616:. During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other
620:, pramocaine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.
115:
812:
681:
used to treat or prevent infections due to its pain relieving effects. However, there is no additional antibiotic effect compared to antibiotics without pramocaine.
813:"Neosporin Plus Pain Relief Ointment, TriBiozene Ointment (neomycin/polymyxin B/ bacitracin/pramoxine) dosing, indications, interactions, adverse effects, and more"
59:
Analpram HC, Caladryl, Caladryl Clear, Cortane-B, Epifoam, Gold Bond
Maximum Relief, Itch-X, Pramosone, Prax, Proctodan-HC, Proctofoam, Tronolane, Vagisil Medicated
138:
857:
568:
64:
524:
890:
1256:
759:
Schmidt JL, Blockus LE, Richards RK (1953). "The
Pharmacology of Pramoxine Hydrochloride: A New Topical Local Anesthetic".
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202:
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552:
InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3
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Topical anesthetics are used to relieve pain and itching caused by conditions such as
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862:(2016 to Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd.).
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8bfeea34-25d5-4721-a17f-d9f1d0084cc3, 81ab7fa7-d9b0-49dc-9782-02f37e588c5e
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Pramocaine is also included in some topical antibiotics like
500:
360:
405:
41:
836:
Salva
Salvatore Joseph De & Migliarese Joseph Francis,
656:
to numb sensitive skin, as does the pain relief variant of
340:
644:, and minor cuts and scratches. The popular itch creams
186:
Depends on country, some formulations OTC others Rx only
793:. U.S. National Library of Medicine. September 25, 2013
758:
717:). Alkylation with 4-(3-chloropropyl)morpholine (
660:and some formulations of Sarna. The hydrochloride
1477:
761:Current Researches in Anesthesia & Analgesia
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632:or other minor burns, insect bites or stings,
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14:
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1100:sclerosing agents for local injection
872:
664:form of pramocaine is water-soluble.
388:
368:
105:
73:
667:Pramocaine is a common component of
160:
150:
348:
251:
24:
25:
1507:
473:
467:
842:(1965 to Colgate Palmolive Co).
557:Key:DQKXQSGTHWVTAD-UHFFFAOYSA-N
845:
830:
805:
779:
476:
461:
13:
1:
740:
532:O(c2ccc(OCCCN1CCOCC1)cc2)CCCC
1159:Capillary stabilising agents
791:MedlinePlus Drug Information
697:The ether formation between
684:
7:
728:
10:
1512:
679:Neosporin Plus Pain Relief
451:Chemical and physical data
1419:
1365:
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1205:
1165:
1158:
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1123:Sodium tetradecyl sulfate
1098:
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713:) gives 4-butoxyphenol (
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133:Topical, rectal, Vaginal
75:International Drug Names
1491:4-Morpholinyl compounds
1108:Monoethanolamine oleate
612:in 1953 and used as an
963:Fluocinolone acetonide
817:reference.medscape.com
694:
623:
839:U.S. patent 3,172,805
692:
1118:Inverted sugar syrup
1090:Pentosan polysulfate
721:) gives pramocaine (
327:hydrochloride:
234:hydrochloride:
851:Li Yuedong, et al.
610:Abbott Laboratories
36:
1146:Calcium dobesilate
695:
648:and some forms of
606:topical anesthetic
32:
1486:Local anesthetics
1473:
1472:
1232:
1231:
1228:
1227:
1154:
1153:
1075:Organo-heparinoid
1044:
1043:
979:local anesthetics
913:Antihemorrhoidals
618:local anesthetics
583:
582:
511:Interactive image
401:CompTox Dashboard
108:
27:Chemical compound
16:(Redirected from
1503:
1437:Counterirritants
1302:Chlorphenoxamine
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1162:
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735:Local anesthesia
669:over the counter
596:, also known as
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44:
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1511:
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1504:
1502:
1501:
1500:
1476:
1475:
1474:
1469:
1427:Corticosteroids
1415:
1369:for topical use
1361:
1317:Diphenhydramine
1273:
1263:
1233:
1224:
1201:
1150:
1132:
1094:
1067:for topical use
1040:
1022:
972:
948:Fluorometholone
924:corticosteroids
915:for topical use
907:
900:Vasoprotectives
897:
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866:
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846:
837:
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767:(6:1): 418–25.
757:
748:
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652:use pramocaine
650:calamine lotion
626:
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572:
569:(what is this?)
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1431:hydrocortisone
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1357:Tripelennamine
1354:
1349:
1344:
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1334:
1329:
1324:
1319:
1314:
1309:
1304:
1299:
1297:Chloropyramine
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1279:Antihistamines
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933:Hydrocortisone
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674:preparations.
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26:
9:
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2:
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1497:
1496:Phenol ethers
1494:
1492:
1489:
1487:
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1455:Difelikefalin
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1425:
1424:
1422:
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1396:Oxybuprocaine
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1266:Antipruritics
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1168:bioflavonoids
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953:Fluocortolone
951:
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943:Betamethasone
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732:
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708:
707:1-bromobutane
704:
700:
693:Patent: Sino:
691:
682:
680:
675:
673:
670:
665:
663:
659:
655:
654:hydrochloride
651:
647:
643:
639:
635:
631:
621:
619:
615:
611:
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603:
602:pramoxine HCl
599:
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438:
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434:ECHA InfoCard
430:
422:
418:
417:DTXSID8040692
414:
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58:
56:
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49:Clinical data
47:
43:
38:
30:
19:
1406:Quinisocaine
1400:
1352:Tolpropamine
1347:Thonzylamine
1337:Promethazine
1322:Isothipendyl
1206:
1166:
1137:
1099:
1059:
1050:Antivaricose
1027:
1017:
977:
968:Fluocinonide
938:Prednisolone
922:
854:CN 106045942
847:
832:
820:. Retrieved
816:
807:
795:. Retrieved
790:
781:
764:
760:
722:
718:
714:
710:
702:
699:hydroquinone
696:
676:
666:
642:poison sumac
627:
614:antipruritic
601:
597:
585:
584:
573:
567:
210:4-morpholine
179:Legal status
173:Legal status
97:License data
29:
1465:Nalfurafine
1381:Cinchocaine
1367:Anesthetics
1342:Thenalidine
1332:Pheniramine
1312:Dimetindene
1215:Tribenoside
1182:Monoxerutin
1113:Polidocanol
1065:heparinoids
1036:Tribenoside
787:"Pramoxine"
494: g·mol
440:100.004.933
194:Identifiers
83:MedlinePlus
55:Trade names
1480:Categories
1411:Tetracaine
1401:Pramocaine
1376:Benzocaine
1327:Mepyramine
1307:Clemastine
1220:Etamsylate
1192:Troxerutin
1018:Pramocaine
1013:Oxetacaine
998:Benzocaine
993:Tetracaine
797:October 9,
741:References
672:hemorrhoid
638:poison oak
634:poison ivy
586:Pramocaine
499:3D model (
487:Molar mass
390:ChEMBL1198
370:CHEBI:8357
330:88AYB867L5
322:068X84E056
293:ChemSpider
220:CAS Number
203:IUPAC name
34:Pramocaine
1391:Lidocaine
1386:Dibucaine
1197:Hidrosmin
1003:Dibucaine
988:Lidocaine
685:Synthesis
658:Neosporin
646:Gold Bond
598:pramoxine
127:Routes of
69:Drugs.com
18:Pramoxine
1441:mint oil
1292:Bamipine
1177:Rutoside
1061:heparins
1008:Procaine
773:13107298
729:See also
576:(verify)
273:DrugBank
237:637-58-1
229:140-65-8
139:ATC code
111:DailyMed
1460:Doxepin
1449:camphor
1445:menthol
1439:(e.g.,
1429:(e.g.,
1283:topical
1187:Diosmin
1085:Heparin
1052:therapy
822:July 3,
630:sunburn
604:) is a
492:293.407
457:Formula
282:DB09345
248:PubChem
159: (
157:C05AD07
155:)
149: (
147:D04AB07
113::
89:a682429
1420:Others
1128:Phenol
859:
771:
705:) and
525:SMILES
381:ChEMBL
350:D08407
109:
1207:other
1138:other
1028:other
545:InChI
501:JSmol
361:ChEBI
1281:for
824:2023
799:2013
769:PMID
662:salt
592:and
341:KEGG
313:UNII
302:4717
262:4886
65:AHFS
1285:use
1270:D04
1063:or
904:C05
725:).
624:Use
600:or
594:BAN
590:INN
406:EPA
252:CID
162:WHO
152:WHO
1482::
1447:,
1443:,
815:.
789:.
765:32
763:.
749:^
640:,
636:,
471:27
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480:3
477:O
474:N
468:H
462:C
408:)
404:(
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67:/
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