20:
184:
Gooding C, Roberts GC, Moreau G, Nadal-Ginard B, Smith CW. (1994). Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon.
171:
Gooding C, Roberts GC, Smith CW. (1998). Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon.
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A number of protein factors bind to or associate with the polypyrimidine tract, including the spliceosome component U2AF and the
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silencing, by which a particular exon region normally spliced into the mature mRNA is instead left out, resulting in the
48:
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Wagner EJ, Garcia-Blanco MA. (2001). Polypyrimidine tract binding protein antagonizes exon definition.
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Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J. (2004).
209:
84:
8:
126:
express alternate isoforms distinguished by mutually exclusive exon selection in alpha-
23:
The essential spliceosome component U2AF bound to a short polypyrimidine RNA fragment.
115:
123:
92:
40:
114:
The suppression or selection of exons is critical to the proper expression of
107:, it is thought to suppress the inclusion of "weak" exons with poorly defined
198:
119:
32:
100:
44:
127:
108:
36:
111:. However, PTB binding is not sufficient to suppress "robust" exons.
55:
52:
104:
67:
63:
16:
A pyrimidine-rich sequence involved in pre-messenger RNA maturation
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19:
71:
59:
88:
103:. Because PTB is ubiquitously expressed in many higher
196:
66:long, located about 5–40 base pairs before the
35:(mRNA) that promotes the assembly of the
83:(PTB), which plays a regulatory role in
18:
178:
197:
165:
152:
139:
80:polypyrimidine tract-binding protein
13:
99:of the protein for which the mRNA
14:
221:
149:WH Freeman: New York, NY. 5th ed.
118:-specific isoforms. For example,
49:post-transcriptional modification
87:. PTB's primary function is in
1:
133:
43:specialized for carrying out
7:
10:
226:
51:. The region is rich with
147:Molecular Cell Biology.
62:, and is usually 15–20
47:during the process of
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22:
85:alternative splicing
29:polypyrimidine tract
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162:21(10):3281-3288.
33:pre-messenger RNA
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205:Gene expression
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189:13(16):3861-72.
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124:skeletal muscle
74:to be spliced.
41:protein complex
31:is a region of
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5:
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160:Mol Cell Biol
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120:smooth muscle
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109:splice sites
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45:RNA splicing
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210:Spliceosome
128:tropomyosin
56:nucleotides
37:spliceosome
199:Categories
134:References
105:eukaryotes
93:expression
64:base pairs
53:pyrimidine
175:4:85-100.
97:isoform
70:of the
187:EMBO J
116:tissue
95:of an
72:intron
68:3' end
60:uracil
39:, the
101:codes
122:and
89:exon
27:The
173:RNA
201::
130:.
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