17:
98:
The three different mechanisms of high iodine response, the
Plummer effect, the Wolff-Chaikoff inhibition effect, and the adaptive escape phenomenon, synergistically work together to fend off potentially harmful consequences of excess iodine load and ensure thyroid homeostasis.
396:"Iodine Content and Distribution in Thyroid Specimens from Two Patients with Graves' Disease Pretreated with Either Propylthiouracil or Stable Iodine: Analysis Using X-Ray Fluorescence and Time-of-Flight Secondary Ion Mass Spectrometry"
111:. Therefore, "plummering" with high-dose iodine is only effective in a short time window after the release of radionuclides. Wrong timing of iodine use may even increase the risk by triggering the Plummer effect.
470:
Zanzonico, PB; Becker, DV (June 2000). "Effects of time of administration and dietary iodine levels on potassium iodide (KI) blockade of thyroid irradiation by 131I from radioactive fallout".
114:
The
Plummer effect is, however, helpful in the management of thyrotoxicosis, where the usage of Lugol’s solution helps to limit the release of thyroid hormones into the bloodstream.
84:, where iodine inhibits the uptake of iodine in thyroid cells and the formation of thyroid hormones, and of the dehalogenase inhibition effect, where high iodine levels block
353:
Solis-S, JC; Villalobos, P; Orozco, A; Delgado, G; Quintanar-Stephano, A; Garcia-Solis, P; Hernandez-Montiel, HL; Robles-Osorio, L; Valverde-R, C (January 2011).
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68:. Today, “Plummering”, i.e. therapy with Lugol's iodine solution, is one of several emergency measures in the management of severe thyrotoxicosis.
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Unlike the Wolff–Chaikoff effect, the
Plummer effect does not prevent the thyroid from taking up radioactive iodine, e.g. in the case of
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95:
The
Plummer effect lasts about 7 to 10 days, but unlike the Wolff-Chaikoff effect, it isn't subject to an escape phenomenon.
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Via the
Plummer effect, a high iodine concentration inhibits the proteolysis of thyroglobulin and the release of pre-formed
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454:
630:
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Nyström, Ernst; Berg, Gertrud E. B.; Jansson, Svante K. G.; Törring, Ove; Valdemarsson, Stig V. (2011).
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513:
Meristoudis, G; Ilias, I (June 2022). "Caveats in the use of potassium iodide for thyroid blocking".
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Plummer, HS (30 June 1923). "Results of administering iodin to patients having exophthalmic goiter".
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162:"Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion"
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Compensatory mechanisms preventing thyrotoxicosis in oversupply with iodine, including the
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Reyes-Castano, John J.; Burman, Kenneth (2014). "Thyrotoxic Crisis: Thyroid Storm".
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Saller, B; Fink, H; Mann, K (1998). "Kinetics of acute and chronic iodine excess".
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Hansson, M; Filipsson Nyström, H; Jansson, S; Lausmaa, J; Berg, G (2012).
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Loriaux, D. Lynn (March 2016). "A Biographical
History of Endocrinology".
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from thyroid follicles. Therefore, its mechanism differs from that of the
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discovered that high-dose iodine may be effective in the treatment of
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24:, the Plummer effect and the dehalogenase inhibition effect
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European
Journal of Nuclear Medicine and Molecular Imaging
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355:"Inhibition of intrathyroidal dehalogenation by iodide"
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Experimental and
Clinical Endocrinology & Diabetes
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Journal of the American Medical Association
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160:Jing, Li; Zhang, Qiang (15 September 2022).
48:in situations of extremely high supply with
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683:Reproductive endocrinology and infertility
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601:Hypothalamic–pituitary–thyroid axis
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44:and preventing the development of
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484:10.1097/00004032-200006000-00008
449:. Berlin: Springer. p. 16.
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32:is one of several physiological
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60:In 1923 the American physician
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36:mechanisms taking place in
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244:10.1002/9781119205791.ch58
166:Frontiers in Endocrinology
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447:Thyroid disease in adults
179:10.3389/fendo.2022.992883
678:Psychoneuroendocrinology
631:Renin–angiotensin system
673:Pediatric endocrinology
647:Blood sugar regulation
332:10.1055/s-0029-1212044
326:. 106 Suppl 3: S34-8.
259:Cite journal requires
124:Jod-Basedow phenomenon
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699:Wolff–Chaikoff effect
283:Endocrine Emergencies
139:Wolff–Chaikoff effect
103:Clinical implications
82:Wolff–Chaikoff effect
62:Henry Stanley Plummer
22:Wolff-Chaikoff effect
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413:10.1155/2012/842357
372:10.1677/JOE-10-0300
109:nuclear emergencies
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583:Physiology
406:: 842357.
172:: 992883.
145:References
88:and other
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72:Mechanism
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118:See also
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56:History
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661:Fields
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488:PMID
451:ISBN
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404:2012
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28:The
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