197:
44:
325:
359:(other than the single bone lesion). The criteria for extramedullary plasmacytoma are the same but the tumor is located in soft tissue. No bone lesions should be present. Criteria for multiple solitary plasmacytomas (+/- recurrent) are the same except either multiple solitary bone or soft tissue lesions must be present. They may occur as multiple primary tumors or as a recurrence from a previous plasmacytoma.
355:(IMWG) has published criteria for the diagnosis of plasmacytomas. They recognise three distinct entities: SPB, extramedullary plasmacytoma and multiple solitary plasmacytomas (+/- recurrent). The proposed criteria for SPB is the presence of a single bone lesion, normal bone marrow (less than 5% plasma cells), small or no paraprotein, no related organ involvement/damage and a normal
451:
Plasmacytomas are a rare form of cancer. SPB is the most common form of the disease and accounts for 3-5% of all plasma cell malignancies. The median age at diagnosis for all plasmacytomas is 55. Both SPB and extramedullary plasmacytoma are more prevalent in males; with a 2:1 male to female ratio for
117:
of bone (SPB); extramedullary plasmacytoma (EP), and multiple plasmacytomas that are either primary or recurrent. The most common of these is SPB, accounting for 3â5% of all plasma cell malignancies. SPBs occur as lytic lesions within the axial skeleton and extramedullary plasmacytomas most often
429:
treatment. In a study that included 68 patients, a group of 8 patients who were treated with radio- and chemotherapy (with or without surgery) were less likey to have a relapse of plasmacytoma, progress to multiple myeloma, or die compared with patients who were treated with radiotherapy and/or
403:
plasma cells. These cells express products of EBV genes such as EBER1 and EBER2. EBV-positive plasmacytoma(s) is more likely to progress to multiple myeloma than EBV-negative plasmacytoma(s) suggesting that the virus may play a role in the progression of plasmacytoma to multiple myeloma.
442:
within 2â4 years of diagnosis, but the overall median survival for SPB is 7â12 years. 30â50% of extramedullary plasmacytoma cases progress to multiple myeloma with a median time of 1.5â2.5 years. 15â45% of SPB and 50â65% of extramedullary plasmacytoma are disease free after 10 years.
250:
spike. This is due to an outgrowth of a single type of plasma cell that forms the plasmacytoma and produces a single type of antibody. The plasma cells are said to be monoclonal and the excessively produced antibody is known as monoclonal protein or
262:
Bone marrow biopsies are performed to ensure the disease is localised; and in SPB or extramedullary plasmacytoma there will not be an increase of monoclonal plasma cells. Tissue biopsies of SPB and extramedullary plasmacytoma are used to assess the
725:
Dimopoulos M, Terpos E, Comenzo RL, et al. (September 2009). "International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple
Myeloma".
392:
424:
is an option for extramedullary plasmacytoma, but for cosmetic reasons it is generally used when the lesion is not present within the head and neck region. Another option is the possible combination of radiotherapy with
415:
is the main choice of treatment for both SPB and extramedullary plasmacytoma, and local control rates of >80% can be achieved. This form of treatment can be used with curative intent because plasmacytoma is a
1281:
1266:
464:" or "solitary myeloma". It is often used as part of the phrase "solitary plasmacytoma". or as part of the phrase "extramedullary plasmacytoma". In this context, "extramedullary" means outside of the
242:
Serum protein electrophoresis separates the proteins in the liquid part of the blood (serum), allowing the analysis of antibodies. Normal blood serum contains a range of antibodies and are said to be
1018:
395:. EBV-positivity is more common in plasmacytoma than multiple myeloma. The tissues involved in EBV+ plasmacytoma typically show foci of EBV+ cells with the appearance of rapidly proliferating
2438:
1407:
932:
Yan J, Wang J, Zhang W, Chen M, Chen J, Liu W (April 2017). "Solitary plasmacytoma associated with
Epstein-Barr virus: a clinicopathologic, cytogenetic study and literature review".
2182:
388:
344:, but they form discrete masses of cells in the skeleton (solitary plasmacytoma of bone; SPB) or in soft tissues (extramedullary plasmacytoma; EP). They do not present with
1400:
1736:
430:
surgery alone . Concerning that study, a large prospective trial is needed to evaluate the impact of adding systemic anti-myeloma treatment to local radiotherapy.
848:
Sekiguchi Y, Shimada A, Ichikawa K, Wakabayashi M, Sugimoto K, Ikeda K, Sekikawa I, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M (2015).
2517:
1853:
1393:
1296:
801:"Guidelines on the diagnosis and management of solitary plasmacytoma of bone, extramedullary plasmacytoma and multiple solitary plasmacytomas: 2009 update"
850:"EpsteinâBarr virus-positive multiple myeloma developing after immunosuppressant therapy for rheumatoid arthritis: a case report and review of literature"
2443:
527:"Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group"
271:(CD) markers are present and to assess monoclonality of the cells. CD markers can aid in the distinction of extramedullary plasmacytoma from lymphomas.
2252:
1455:
487:
2466:
1818:
2512:
2208:
285:. MRI can be used to assess tumor status and may be advantageous in detecting primary tumors that are not detected by plain film radiography.
1547:
974:"Clinical features, therapy patterns, outcomes and prognostic factors of solitary plasmacytomas: a report of the Israeli Myeloma Study Group"
1898:
2411:
2450:
1996:
1875:
1741:
141:. For SPB and extramedullary plasmacytoma the distinction is the presence of only one lesion (either in bone or soft tissue), normal
1078:
2507:
1976:
1774:
1197:"Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics"
2400:
2074:
1628:
2247:
800:
2066:
1617:
832:
493:
2395:
1023:
2351:
1971:
1769:
1653:
352:
110:
2299:
2010:
2242:
575:"Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma"
1540:
1239:
387:. EBV-positive multiple myeloma and plasmacytoma are classified together by the World Health Organization (2016) as
2203:
889:
Rezk SA, Zhao X, Weiss LM (June 2018). "Epstein - Barr virus - associated lymphoid proliferations, a 2018 update".
769:
O'Connell TX, Horita TJ, Kasravi B (January 2005). "Understanding and interpreting serum protein electrophoresis".
114:
26:
1470:
2433:
2425:
2284:
2162:
2101:
2087:
1981:
1922:
1759:
1685:
130:, but surgery is used in some cases of extramedullary plasmacytoma. The skeletal forms frequently progress to
2481:
2391:
2341:
2237:
1966:
1750:
212:
200:
2373:
2279:
2262:
2070:
1624:
1533:
1416:
1373:
2314:
2187:
1893:
1038:
2229:
1489:
1477:
268:
196:
2117:
1958:
1880:
1243:
498:
371:(EBV) is associated with multiple myeloma and plasmacytomas, particularly in individuals who have an
290:
973:
2319:
2147:
1311:
228:
1785:
170:
162:
119:
304:. The difference between plasmacytoma and multiple myeloma is that plasmacytoma lacks increased
2336:
2213:
2192:
2106:
1887:
1506:
1385:
396:
368:
289:
may also be beneficial in detecting extramedullary tumours in individuals diagnosed with SPB.
2345:
1935:
1908:
1829:
1731:
1428:
477:
461:
380:
247:
243:
211:
The diagnosis of plasmacytoma uses a diverse range of interdisciplinary techniques including
166:
88:
1525:
2142:
1754:
1665:
1573:
1449:
460:
There can be some ambiguity when using the word. "Plasmacytoma" is sometimes equated with "
384:
224:
267:
of the plasma cells. Histological analyses can be performed on these biopsies to see what
8:
1942:
1726:
1696:
1482:
1285:
1098:
309:
220:
825:
Pathology and
Genetics of Haemo (World Health Organization Classification of Tumours S.)
2406:
1305:
1301:
1138:
1113:
1001:
914:
866:
849:
751:
699:
672:
216:
1290:
945:
2486:
2137:
2126:
1916:
1806:
1721:
1466:
1322:
1218:
1177:
1143:
1090:
1059:
1005:
993:
949:
906:
871:
828:
778:
743:
704:
646:
596:
591:
548:
543:
526:
296:
An important distinction to be made is that a true plasmacytoma is present and not a
67:
2156:
918:
755:
641:
624:
2256:
2035:
1903:
1802:
1514:
1461:
1445:
1362:
1208:
1133:
1125:
1051:
985:
941:
898:
861:
735:
694:
684:
636:
586:
538:
482:
439:
426:
417:
372:
345:
341:
301:
297:
138:
131:
20:
989:
902:
2029:
2024:
1833:
1717:
1583:
1578:
1432:
1316:
1129:
1079:"Up-date on solitary plasmacytoma and its main differences with multiple myeloma"
356:
274:
203:
of an individual with polyclonal antibodies (top) and an individual with a large
157:
For SPB the most common presenting symptom is that of pain in the affected bone.
146:
123:
122:(85%), but can occur in any soft tissue. Approximately half of all cases produce
2476:
1494:
282:
278:
137:
Due to their cellular similarity, plasmacytomas have to be differentiated from
103:
1327:
1275:
2501:
2383:
2082:
1991:
1947:
1764:
1638:
1055:
305:
673:"A review for solitary plasmacytoma of bone and extramedullary plasmacytoma"
259:
are present in 60% of SPB and less than 25% of extramedullary plasmacytoma.
1648:
1222:
1213:
1196:
1181:
1147:
1094:
1063:
997:
953:
910:
875:
782:
747:
708:
650:
600:
552:
412:
127:
59:
689:
316:
in the bloodstream, and multiple bone lesions (collectively termed CRAB).
43:
1660:
1162:
1036:
Dimopoulos MA, Moulopoulos LA, Maniatis A, Alexanian R (September 2000).
670:
465:
337:
256:
252:
204:
181:
142:
99:
92:
1258:
739:
1556:
72:
51:
16:
Growth of a plasma cell tumour within soft tissue or the axial skeleton
1035:
348:, which would classify them as another systemic plasma cell disorder.
1357:
1333:
400:
293:
may be better than plain film radiography for assessing bone damage.
264:
177:
158:
1114:"Immunoglobulin free light chains and solitary plasmacytoma of bone"
2471:
1560:
1419:
1368:
847:
574:
524:
376:
185:
76:
1338:
1039:"Solitary plasmacytoma of bone and asymptomatic multiple myeloma"
671:
Kilciksiz S, Karakoyun-Celik O, Agaoglu FY, Haydaroglu A (2012).
421:
1415:
1160:
324:
169:. Around 85% of extramedullary plasmacytoma presents within the
126:. SPBs and extramedullary plasmacytomas are mostly treated with
2019:
1270:
1161:
Megat Shiraz MA, Jong YH, Primuharsa Putra SH (November 2008).
798:
313:
286:
236:
173:
95:
1112:
Dingli D, Kyle RA, Rajkumar SV, et al. (September 2006).
1842:
1707:
1691:
1555:
333:
1195:
Bink K, Haralambieva E, Kremer M, et al. (April 2008).
972:
Ganzel C, Trestman S, Levi S, et al. (September 2022).
854:
International
Journal of Clinical and Experimental Pathology
184:
and nasal obstruction. In some tissues it may be found as a
161:
and other consequences of the bone lesion may occur such as
2305:
2199:
2183:
Non-mycosis fungoides CD30â cutaneous large T-cell lymphoma
2178:
2096:
1838:
1813:
1793:
1789:
1676:
1594:
1589:
246:, whereas serum from a person with plasmacytoma may show a
768:
573:
Soutar R, Lucraft H, Jackson G, et al. (March 2004).
389:
EpsteinâBarr virus-associated lymphoproliferative diseases
362:
2045:
2040:
1930:
232:
794:
792:
724:
1194:
789:
452:
SPB and a 3:1 ratio for extramedullary plasmacytoma.
149:, absent or low paraprotein and no end organ damage.
1248:
1163:"Extramedullary plasmacytoma in the maxillary sinus"
799:
M. Hughes; R. Soutar; H. Lucraft; R. Owen; J. Bird.
572:
2253:Peripheral T-cell lymphoma not otherwise specified
1111:
1037:
971:
488:Monoclonal gammopathy of undetermined significance
27:Plasma cell dyscrasia § Solitary plasmacytoma
2075:Precursor T acute lymphoblastic leukemia/lymphoma
1629:Precursor B acute lymphoblastic leukemia/lymphoma
525:International Myeloma Working Group (June 2003).
393:EpsteinâBarr virus-associated plasma cell myeloma
2499:
1076:
931:
817:
1819:Nodular lymphocyte predominant Hodgkin lymphoma
967:
965:
963:
625:"Solitary bone and extramedullary plasmacytoma"
720:
718:
666:
664:
662:
660:
618:
616:
614:
612:
610:
568:
566:
564:
562:
520:
518:
516:
514:
383:, or a chronic inflammatory condition such as
2209:Secondary cutaneous CD30+ large-cell lymphoma
1541:
1401:
888:
1899:Post-transplant lymphoproliferative disorder
1854:immunoproliferative immunoglobulin disorders
1188:
1154:
1105:
1070:
1029:
960:
925:
882:
2412:Diffuse infiltrative lymphocytosis syndrome
841:
762:
715:
657:
607:
559:
511:
340:. The cells are identical to those seen in
2451:Jessner lymphocytic infiltrate of the skin
1997:Primary cutaneous follicle center lymphoma
1742:Primary cutaneous follicle center lymphoma
1548:
1534:
1408:
1394:
42:
1212:
1137:
865:
698:
688:
640:
590:
542:
1977:Primary cutaneous marginal zone lymphoma
1775:Primary cutaneous marginal zone lymphoma
622:
323:
195:
2439:with bandlike and perivascular patterns
2401:Autoimmune lymphoproliferative syndrome
363:Association with the EpsteinâBarr virus
2518:EpsteinâBarr virusâassociated diseases
2500:
2248:Enteropathy-associated T-cell lymphoma
629:Hematology Am Soc Hematol Educ Program
277:are used to ensure there are no other
2513:Lymphoid-related cutaneous conditions
1529:
1389:
1077:Di Micco P, Di Micco B (March 2005).
152:
2396:X-linked lymphoproliferative disease
176:, causing possible symptoms such as
2352:Large granular lymphocytic leukemia
1972:Intravascular large B-cell lymphoma
353:International Myeloma Working Group
111:International Myeloma Working Group
13:
14:
2529:
1233:
946:10.1016/j.anndiagpath.2016.09.002
319:
592:10.1111/j.1365-2141.2004.04834.x
544:10.1046/j.1365-2141.2003.04355.x
2508:Hematologic malignant neoplasms
2204:CD30+ cutaneous T-cell lymphoma
1012:
642:10.1182/asheducation-2005.1.373
494:Waldenström's macroglobulinemia
446:
2434:Cutaneous lymphoid hyperplasia
2426:Cutaneous lymphoid hyperplasia
2285:Adult T-cell leukemia/lymphoma
2163:Adult T-cell leukemia/lymphoma
2102:Anaplastic large-cell lymphoma
1982:Primary cutaneous immunocytoma
1923:Splenic marginal zone lymphoma
934:Annals of Diagnostic Pathology
455:
438:Most cases of SPB progress to
300:plasma cell disorder, such as
145:(<5% plasma cells), normal
134:over the course of 2â4 years.
1:
2482:Lymphoproliferative disorders
2392:Lymphoproliferative disorders
2342:Extranodal NK-T-cell lymphoma
2214:Lymphomatoid papulosis type A
2193:Lymphomatoid papulosis type B
2107:Lymphomatoid papulosis type A
1967:Diffuse large B-cell lymphoma
1471:Waldenström macroglobulinemia
990:10.1080/10428194.2022.2118535
903:10.1016/j.humpath.2018.05.020
504:
328:Micrograph of a plasmacytoma.
213:serum protein electrophoresis
201:Serum protein electrophoresis
2374:Acute biphenotypic leukaemia
2263:Subcutaneous T-cell lymphoma
1130:10.1182/blood-2006-04-015784
1024:Dorland's Medical Dictionary
433:
407:
191:
7:
2315:Aggressive NK-cell leukemia
2188:Pleomorphic T-cell lymphoma
1894:Lymphomatoid granulomatosis
471:
10:
2534:
269:cluster of differentiation
24:
18:
2459:
2424:
2382:
2364:
2328:
2298:
2271:
2226:
2171:
2125:
2116:
2056:
2018:
2009:
1957:
1867:
1828:
1784:
1706:
1675:
1637:
1616:
1605:
1572:
1568:
1504:
1427:
1348:
1252:
1244:National Cancer Institute
499:Cutaneous B-cell lymphoma
310:decreased kidney function
66:
50:
41:
36:
2467:Hematological malignancy
2320:Blastic NK cell lymphoma
2148:Granulomatous slack skin
1904:Classic Hodgkin lymphoma
1803:Classic Hodgkin lymphoma
1056:10.1182/blood.V96.6.2037
827:. Oxford Univ Pr. 2003.
314:too few red blood cells
171:upper respiratory tract
163:spinal cord compression
120:upper respiratory tract
1507:hypergammaglobulinemia
1214:10.3324/haematol.12005
677:ScientificWorldJournal
329:
229:plain film radiography
208:
2346:Angiocentric lymphoma
1936:AIDS-related lymphoma
1760:Splenic marginal zone
478:Plasma cell dyscrasia
462:plasma cell dyscrasia
401:poorly differentiated
381:organ transplantation
327:
219:, urine analysis for
199:
167:pathological fracture
115:solitary plasmacytoma
89:plasma cell dyscrasia
2444:with nodular pattern
2143:Pagetoid reticulosis
1755:marginal zone B-cell
1450:Plasma cell leukemia
385:rheumatoid arthritis
225:complete blood count
1943:Helicobacter pylori
1770:Nodal marginal zone
1697:Hairy cell leukemia
1563:and related disease
1495:Primary amyloidosis
1483:Heavy chain disease
1417:Immunoproliferative
740:10.1038/leu.2009.89
690:10.1100/2012/895765
221:Bence Jones protein
113:lists three types:
2487:Lymphoid leukemias
2407:Leukemoid reaction
2243:Angioimmunoblastic
1909:Burkitt's lymphoma
1349:External resources
369:EpsteinâBarr virus
332:Plasmacytoma is a
330:
217:bone marrow biopsy
209:
153:Signs and symptoms
2495:
2494:
2420:
2419:
2360:
2359:
2294:
2293:
2222:
2221:
2138:Mycosis fungoides
2005:
2004:
1863:
1862:
1807:Nodular sclerosis
1722:follicular B cell
1523:
1522:
1467:Macroglobulinemia
1383:
1382:
984:(14): 3448â3455.
834:978-92-832-2411-2
623:Weber DM (2005).
82:
81:
31:Medical condition
2525:
2257:Lennert lymphoma
2123:
2122:
2054:
2053:
2016:
2015:
1881:Primary effusion
1614:
1613:
1603:
1602:
1570:
1569:
1550:
1543:
1536:
1527:
1526:
1515:Cryoglobulinemia
1446:Multiple myeloma
1410:
1403:
1396:
1387:
1386:
1250:
1249:
1227:
1226:
1216:
1192:
1186:
1185:
1167:
1158:
1152:
1151:
1141:
1109:
1103:
1102:
1097:. Archived from
1074:
1068:
1067:
1041:
1033:
1027:
1016:
1010:
1009:
969:
958:
957:
929:
923:
922:
886:
880:
879:
869:
845:
839:
838:
821:
815:
814:
812:
810:
805:
796:
787:
786:
771:Am Fam Physician
766:
760:
759:
722:
713:
712:
702:
692:
668:
655:
654:
644:
620:
605:
604:
594:
570:
557:
556:
546:
522:
483:Multiple myeloma
440:multiple myeloma
427:multiple myeloma
373:immunodeficiency
346:systemic disease
342:multiple myeloma
302:multiple myeloma
275:Skeletal surveys
139:multiple myeloma
132:multiple myeloma
46:
34:
33:
21:Multiple myeloma
2533:
2532:
2528:
2527:
2526:
2524:
2523:
2522:
2498:
2497:
2496:
2491:
2455:
2416:
2378:
2366:
2356:
2324:
2303:
2290:
2267:
2228:
2218:
2167:
2112:
2060:
2058:
2033:
2028:
2022:
2001:
1953:
1859:
1836:
1824:
1780:
1718:germinal center
1702:
1671:
1633:
1609:
1607:
1587:
1582:
1576:
1564:
1554:
1524:
1519:
1500:
1423:
1414:
1384:
1379:
1378:
1344:
1343:
1261:
1236:
1231:
1230:
1193:
1189:
1170:Singapore Med J
1165:
1159:
1155:
1110:
1106:
1075:
1071:
1034:
1030:
1017:
1013:
970:
961:
930:
926:
891:Human Pathology
887:
883:
860:(2): 2090â102.
846:
842:
835:
823:
822:
818:
808:
806:
803:
797:
790:
767:
763:
723:
716:
669:
658:
621:
608:
579:Br. J. Haematol
571:
560:
531:Br. J. Haematol
523:
512:
507:
474:
458:
449:
436:
410:
365:
357:skeletal survey
322:
194:
155:
147:skeletal survey
124:paraproteinemia
32:
29:
23:
17:
12:
11:
5:
2531:
2521:
2520:
2515:
2510:
2493:
2492:
2490:
2489:
2484:
2479:
2477:Leukemia cutis
2474:
2469:
2463:
2461:
2457:
2456:
2454:
2453:
2448:
2447:
2446:
2441:
2430:
2428:
2422:
2421:
2418:
2417:
2415:
2414:
2409:
2404:
2398:
2388:
2386:
2380:
2379:
2377:
2376:
2370:
2368:
2362:
2361:
2358:
2357:
2355:
2354:
2349:
2332:
2330:
2326:
2325:
2323:
2322:
2317:
2311:
2309:
2296:
2295:
2292:
2291:
2289:
2288:
2275:
2273:
2269:
2268:
2266:
2265:
2260:
2250:
2245:
2240:
2234:
2232:
2224:
2223:
2220:
2219:
2217:
2216:
2211:
2206:
2196:
2195:
2190:
2185:
2175:
2173:
2169:
2168:
2166:
2165:
2157:SĂ©zary disease
2151:
2150:
2145:
2140:
2131:
2129:
2120:
2114:
2113:
2111:
2110:
2104:
2092:
2091:
2088:Prolymphocytic
2078:
2064:
2062:
2051:
2050:
2049:
2043:
2013:
2007:
2006:
2003:
2002:
2000:
1999:
1994:
1989:
1984:
1979:
1974:
1969:
1963:
1961:
1955:
1954:
1952:
1951:
1939:
1927:
1926:
1925:
1913:
1912:
1911:
1906:
1901:
1896:
1884:
1871:
1869:
1865:
1864:
1861:
1860:
1858:
1857:
1848:
1846:
1826:
1825:
1823:
1822:
1810:
1799:
1797:
1782:
1781:
1779:
1778:
1772:
1767:
1762:
1746:
1745:
1739:
1734:
1729:
1713:
1711:
1704:
1703:
1701:
1700:
1688:
1686:Prolymphocytic
1682:
1680:
1673:
1672:
1670:
1669:
1657:
1644:
1642:
1635:
1634:
1632:
1622:
1620:
1611:
1600:
1599:
1598:
1566:
1565:
1553:
1552:
1545:
1538:
1530:
1521:
1520:
1518:
1517:
1511:
1509:
1502:
1501:
1499:
1498:
1486:
1474:
1458:
1453:
1443:
1437:
1435:
1425:
1424:
1420:immunoglobulin
1413:
1412:
1405:
1398:
1390:
1381:
1380:
1377:
1376:
1365:
1353:
1352:
1350:
1346:
1345:
1342:
1341:
1330:
1319:
1308:
1293:
1278:
1262:
1257:
1256:
1254:
1253:Classification
1247:
1246:
1235:
1234:External links
1232:
1229:
1228:
1187:
1176:(11): e310â1.
1153:
1124:(6): 1979â83.
1104:
1101:on 2009-01-07.
1069:
1050:(6): 2037â44.
1028:
1019:"plasmacytoma"
1011:
959:
924:
881:
840:
833:
816:
788:
761:
734:(9): 1545â56.
714:
656:
606:
558:
509:
508:
506:
503:
502:
501:
496:
491:
485:
480:
473:
470:
457:
454:
448:
445:
435:
432:
418:radiosensitive
409:
406:
364:
361:
321:
320:Classification
318:
283:axial skeleton
279:primary tumors
193:
190:
154:
151:
104:axial skeleton
102:or within the
80:
79:
70:
64:
63:
48:
47:
39:
38:
30:
15:
9:
6:
4:
3:
2:
2530:
2519:
2516:
2514:
2511:
2509:
2506:
2505:
2503:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2464:
2462:
2458:
2452:
2449:
2445:
2442:
2440:
2437:
2436:
2435:
2432:
2431:
2429:
2427:
2423:
2413:
2410:
2408:
2405:
2402:
2399:
2397:
2393:
2390:
2389:
2387:
2385:
2384:Lymphocytosis
2381:
2375:
2372:
2371:
2369:
2363:
2353:
2350:
2347:
2343:
2339:
2338:
2334:
2333:
2331:
2327:
2321:
2318:
2316:
2313:
2312:
2310:
2307:
2301:
2297:
2286:
2282:
2281:
2277:
2276:
2274:
2270:
2264:
2261:
2258:
2254:
2251:
2249:
2246:
2244:
2241:
2239:
2238:Hepatosplenic
2236:
2235:
2233:
2231:
2225:
2215:
2212:
2210:
2207:
2205:
2201:
2198:
2197:
2194:
2191:
2189:
2186:
2184:
2180:
2177:
2176:
2174:
2170:
2164:
2161:
2160:
2159:
2158:
2155:
2149:
2146:
2144:
2141:
2139:
2136:
2133:
2132:
2130:
2128:
2124:
2121:
2119:
2115:
2108:
2105:
2103:
2099:
2098:
2094:
2093:
2089:
2085:
2084:
2083:prolymphocyte
2080:
2079:
2076:
2072:
2068:
2065:
2063:
2055:
2052:
2047:
2044:
2042:
2039:
2038:
2037:
2031:
2026:
2021:
2017:
2014:
2012:
2008:
1998:
1995:
1993:
1992:Plasmacytosis
1990:
1988:
1985:
1983:
1980:
1978:
1975:
1973:
1970:
1968:
1965:
1964:
1962:
1960:
1956:
1949:
1948:MALT lymphoma
1945:
1944:
1940:
1937:
1933:
1932:
1928:
1924:
1921:
1920:
1919:
1918:
1914:
1910:
1907:
1905:
1902:
1900:
1897:
1895:
1892:
1891:
1890:
1889:
1885:
1882:
1878:
1877:
1873:
1872:
1870:
1866:
1856:
1855:
1850:
1849:
1847:
1844:
1840:
1835:
1831:
1827:
1820:
1816:
1815:
1811:
1808:
1804:
1801:
1800:
1798:
1795:
1791:
1787:
1783:
1776:
1773:
1771:
1768:
1766:
1763:
1761:
1757:
1756:
1752:
1751:marginal zone
1748:
1747:
1743:
1740:
1738:
1735:
1733:
1730:
1728:
1724:
1723:
1719:
1715:
1714:
1712:
1709:
1705:
1698:
1694:
1693:
1689:
1687:
1684:
1683:
1681:
1678:
1674:
1667:
1663:
1662:
1658:
1655:
1651:
1650:
1646:
1645:
1643:
1640:
1636:
1630:
1626:
1623:
1621:
1619:
1615:
1612:
1604:
1601:
1596:
1593:
1592:
1591:
1585:
1580:
1575:
1571:
1567:
1562:
1558:
1551:
1546:
1544:
1539:
1537:
1532:
1531:
1528:
1516:
1513:
1512:
1510:
1508:
1503:
1496:
1492:
1491:
1487:
1484:
1480:
1479:
1475:
1472:
1468:
1464:
1463:
1459:
1457:
1454:
1451:
1447:
1444:
1442:
1439:
1438:
1436:
1434:
1430:
1426:
1421:
1418:
1411:
1406:
1404:
1399:
1397:
1392:
1391:
1388:
1375:
1371:
1370:
1366:
1364:
1360:
1359:
1355:
1354:
1351:
1347:
1340:
1336:
1335:
1331:
1329:
1325:
1324:
1320:
1318:
1314:
1313:
1309:
1307:
1303:
1299:
1298:
1294:
1292:
1288:
1287:
1283:
1279:
1277:
1273:
1272:
1268:
1264:
1263:
1260:
1255:
1251:
1245:
1241:
1238:
1237:
1224:
1220:
1215:
1210:
1206:
1202:
1201:Haematologica
1198:
1191:
1183:
1179:
1175:
1171:
1164:
1157:
1149:
1145:
1140:
1135:
1131:
1127:
1123:
1119:
1115:
1108:
1100:
1096:
1092:
1088:
1084:
1080:
1073:
1065:
1061:
1057:
1053:
1049:
1045:
1040:
1032:
1026:
1025:
1020:
1015:
1007:
1003:
999:
995:
991:
987:
983:
979:
978:Leuk Lymphoma
975:
968:
966:
964:
955:
951:
947:
943:
939:
935:
928:
920:
916:
912:
908:
904:
900:
896:
892:
885:
877:
873:
868:
863:
859:
855:
851:
844:
836:
830:
826:
820:
802:
795:
793:
784:
780:
777:(1): 105â12.
776:
772:
765:
757:
753:
749:
745:
741:
737:
733:
729:
721:
719:
710:
706:
701:
696:
691:
686:
682:
678:
674:
667:
665:
663:
661:
652:
648:
643:
638:
634:
630:
626:
619:
617:
615:
613:
611:
602:
598:
593:
588:
585:(6): 717â26.
584:
580:
576:
569:
567:
565:
563:
554:
550:
545:
540:
537:(5): 749â57.
536:
532:
528:
521:
519:
517:
515:
510:
500:
497:
495:
492:
489:
486:
484:
481:
479:
476:
475:
469:
467:
463:
453:
444:
441:
431:
428:
423:
419:
414:
405:
402:
398:
394:
390:
386:
382:
378:
374:
370:
360:
358:
354:
349:
347:
343:
339:
335:
326:
317:
315:
311:
307:
306:blood calcium
303:
299:
294:
292:
288:
284:
280:
276:
272:
270:
266:
260:
258:
254:
249:
245:
240:
238:
234:
230:
226:
222:
218:
214:
206:
202:
198:
189:
187:
186:palpable mass
183:
179:
175:
172:
168:
164:
160:
150:
148:
144:
140:
135:
133:
129:
125:
121:
118:occur in the
116:
112:
107:
105:
101:
98:grows within
97:
94:
90:
86:
78:
74:
71:
69:
65:
61:
60:H&E stain
57:
53:
49:
45:
40:
35:
28:
22:
2335:
2278:
2272:By infection
2153:
2152:
2134:
2095:
2081:
2059:development/
1987:Plasmacytoma
1986:
1941:
1929:
1915:
1886:
1874:
1868:By infection
1851:
1812:
1749:
1716:
1690:
1659:
1649:naive B cell
1647:
1608:development/
1488:
1476:
1460:
1441:Plasmacytoma
1440:
1367:
1356:
1332:
1321:
1310:
1295:
1280:
1265:
1207:(4): 623â6.
1204:
1200:
1190:
1173:
1169:
1156:
1121:
1117:
1107:
1099:the original
1086:
1082:
1072:
1047:
1043:
1031:
1022:
1014:
981:
977:
937:
933:
927:
894:
890:
884:
857:
853:
843:
824:
819:
807:. Retrieved
774:
770:
764:
731:
727:
680:
676:
632:
628:
582:
578:
534:
530:
459:
450:
447:Epidemiology
437:
413:Radiotherapy
411:
375:due to e.g.
367:Rarely, the
366:
350:
338:plasma cells
331:
295:
273:
261:
257:Paraproteins
241:
210:
156:
136:
128:radiotherapy
108:
85:Plasmacytoma
84:
83:
56:plasmacytoma
55:
37:Plasmacytoma
2154:aggressive:
2127:MF+variants
1666:Mantle cell
1661:mantle zone
1490:light chain
1478:heavy chain
1089:(1): 7â12.
466:bone marrow
456:Terminology
391:and termed
281:within the
253:paraprotein
205:paraprotein
182:rhinorrhoea
143:bone marrow
100:soft tissue
93:plasma cell
91:in which a
2502:Categories
2230:peripheral
1727:Follicular
1557:Leukaemias
1323:DiseasesDB
1083:Exp. Oncol
809:January 2,
505:References
291:CT imaging
248:monoclonal
244:polyclonal
73:Hematology
52:Micrograph
25:See also:
19:See also:
2365:Lymphoid+
2135:indolent:
2118:Cutaneous
1959:Cutaneous
1737:GCB DLBCL
1732:Burkitt's
1561:lymphomas
1422:disorders
1358:eMedicine
1334:SNOMED CT
1006:252161148
897:: 18â41.
635:: 373â6.
434:Prognosis
408:Treatment
265:phenotype
207:(bottom).
192:Diagnosis
178:epistaxis
159:Back pain
68:Specialty
2472:leukemia
2030:leukemia
2025:lymphoma
1584:leukemia
1579:lymphoma
1369:Orphanet
1363:med/2532
1339:10639003
1240:Overview
1223:18326524
1182:19037537
1148:16741249
1095:15812350
1064:10979944
998:36075048
954:28325354
919:47010934
911:29885408
876:25973110
783:15663032
756:13264295
748:19421229
728:Leukemia
709:22654647
651:16304406
601:15009059
553:12780789
472:See also
397:immature
377:HIV/AIDS
298:systemic
77:oncology
2460:General
2367:myeloid
2329:T or NK
2300:NK cell
1654:CLL/SLL
1317:D010954
1306:M9734/3
1302:M9731/3
1139:1895544
940:: 1â6.
867:4396324
700:3354668
683:: 1â6.
422:Surgery
420:tumor.
2304:(most
2280:HTLV-1
2172:Non-MF
2061:marker
2034:(most
2020:T cell
1692:CD11c+
1610:marker
1588:(most
1574:B cell
1505:Other
1221:
1180:
1146:
1136:
1093:
1062:
1004:
996:
952:
917:
909:
874:
864:
831:
781:
754:
746:
707:
697:
649:
599:
551:
490:(MGUS)
287:PET-CT
237:PET-CT
174:mucosa
96:tumour
2227:Other
2097:CD30+
1843:CD138
1814:CD20+
1708:CD79a
1374:86855
1297:ICD-O
1291:238.6
1276:C90.2
1166:(PDF)
1118:Blood
1044:Blood
1002:S2CID
915:S2CID
804:(PDF)
752:S2CID
425:anti-
334:tumor
87:is a
54:of a
2306:CD56
2200:CD30
2179:CD30
2067:TdT+
2011:T/NK
1876:KSHV
1852:see
1839:CD38
1830:PCDs
1794:CD30
1790:CD15
1765:MALT
1677:CD22
1618:TdT+
1595:CD20
1590:CD19
1456:MGUS
1429:PCDs
1328:8628
1312:MeSH
1286:9-CM
1219:PMID
1178:PMID
1144:PMID
1091:PMID
1060:PMID
994:PMID
950:PMID
907:PMID
872:PMID
829:ISBN
811:2019
779:PMID
744:PMID
705:PMID
681:2012
647:PMID
633:2005
597:PMID
549:PMID
351:The
235:and
223:and
109:The
75:and
2337:EBV
2202:+:
2181:-:
2071:ALL
2046:CD8
2041:CD4
2036:CD3
1931:HIV
1917:HCV
1888:EBV
1792:+,
1639:CD5
1625:ALL
1462:IgM
1282:ICD
1267:ICD
1242:at
1209:doi
1134:PMC
1126:doi
1122:108
1052:doi
1021:at
986:doi
942:doi
899:doi
862:PMC
736:doi
695:PMC
685:doi
637:doi
587:doi
583:124
539:doi
535:121
399:or
336:of
255:.
233:MRI
165:or
2504::
2069::
2057:By
1845:+)
1841:+/
1834:PP
1796:+)
1786:RS
1606:By
1559:,
1433:PP
1372::
1361::
1337::
1326::
1315::
1304:,
1300::
1289::
1274::
1271:10
1217:.
1205:93
1203:.
1199:.
1174:49
1172:.
1168:.
1142:.
1132:.
1120:.
1116:.
1087:27
1085:.
1081:.
1058:.
1048:96
1046:.
1042:.
1000:.
992:.
982:63
980:.
976:.
962:^
948:.
938:27
936:.
913:.
905:.
895:79
893:.
870:.
856:.
852:.
791:^
775:71
773:.
750:.
742:.
732:23
730:.
717:^
703:.
693:.
679:.
675:.
659:^
645:.
631:.
627:.
609:^
595:.
581:.
577:.
561:^
547:.
533:.
529:.
513:^
468:.
379:,
312:,
308:,
239:.
231:,
227:,
215:,
188:.
180:,
106:.
58:.
2403:)
2394:(
2348:)
2344:/
2340:(
2308:)
2302:/
2287:)
2283:(
2259:)
2255:(
2109:)
2100:(
2090:)
2086:(
2077:)
2073:(
2048:)
2032:)
2027:,
2023:(
1950:)
1946:(
1938:)
1934:(
1883:)
1879:(
1837:(
1832:/
1821:)
1817:(
1809:)
1805:(
1788:(
1777:)
1758:(
1753:/
1744:)
1725:(
1720:/
1710:+
1699:)
1695:(
1679:+
1668:)
1664:(
1656:)
1652:(
1641:+
1631:)
1627:(
1597:)
1586:)
1581:,
1577:(
1549:e
1542:t
1535:v
1497:)
1493:(
1485:)
1481:(
1473:)
1469:/
1465:(
1452:)
1448:(
1431:/
1409:e
1402:t
1395:v
1284:-
1269:-
1259:D
1225:.
1211::
1184:.
1150:.
1128::
1066:.
1054::
1008:.
988::
956:.
944::
921:.
901::
878:.
858:8
837:.
813:.
785:.
758:.
738::
711:.
687::
653:.
639::
603:.
589::
555:.
541::
62:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
