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Performance-enhancing substance

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decennia however, it became clear that the central nervous system plays an important role in the onset of fatigue during prolonged exercise (Klass et al., 2008), certainly when ambient temperature is increased ... 5-HT, DA, and NA have all been implicated in the control of thermoregulation and are thought to mediate thermoregulatory responses, certainly since their neurons innervate the hypothalamus (Roelands & Meeusen, 2010). ... This indicates that subjects did not feel they were producing more power and consequently more heat. The authors concluded that the "safety switch" or the mechanisms existing in the body to prevent harmful effects are overridden by the drug administration (Roelands et al., 2008b). Taken together, these data indicate strong ergogenic effects of an increased DA concentration in the brain, without any change in the perception of effort. ... The combined effects of DA and NA on performance in the heat were studied by our research group on a number of occasions. ... the administration of bupropion (DA/NA reuptake inhibitor) significantly improved performance. Coinciding with this ergogenic effect, the authors observed core temperatures that were much higher compared with the placebo situation. Interestingly, this occurred without any change in the subjective feelings of thermal sensation or perceived exertion. Similar to the methylphenidate study (Roelands et al., 2008b), bupropion may dampen or override inhibitory signals arising from the central nervous system to cease exercise because of hyperthermia, and enable an individual to continue maintaining a high power output
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addition, we examined the evidence for publication bias. Forty-eight studies (total of 1,409 participants) were included in the analyses. We found evidence for small but significant stimulant enhancement effects on inhibitory control and short-term episodic memory. Small effects on working memory reached significance, based on one of our two analytical approaches. Effects on delayed episodic memory were medium in size. However, because the effects on long-term and working memory were qualified by evidence for publication bias, we conclude that the effect of amphetamine and methylphenidate on the examined facets of healthy cognition is probably modest overall. In some situations, a small advantage may be valuable, although it is also possible that healthy users resort to stimulants to enhance their energy and motivation more than their cognition. ... Earlier research has failed to distinguish whether stimulants' effects are small or whether they are nonexistent (Ilieva et al., 2013; Smith & Farah, 2011). The present findings supported generally small effects of amphetamine and methylphenidate on executive function and memory. Specifically, in a set of experiments limited to high-quality designs, we found significant enhancement of several cognitive abilities. ...
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dextroamphetamine versus placebo. Most of the information to answer this question has been obtained in the past decade through studies of fatigue rather than an attempt to systematically investigate the effect of ADHD drugs on exercise. ... In 2008, Roelands and colleagues studied the effect of reboxetine, a pure NE reuptake inhibitor, similar to atomoxetine, in 9 healthy, well-trained cyclists. They too exercised in both temperate and warm environments. They showed decreased power output and exercise performance at both 18 and 30 degrees centigrade. Their conclusion was that DA reuptake inhibition was the cause of the increased exercise performance seen with drugs that affect both DA and NE (MPH, amphetamine, and bupropion).
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Studies have shown that the most common gendered risk factors include being an adolescent female dissatisfied with their body weight or an adolescent male who perceives larger body sizes as the ideal. Having a negative body image or a history of depression can also be a significant risk factor. These are further exacerbated by parental pressures surrounding appearance, media influence, and peer pressure.
390:: one of the most popular nutritional supplements, it contributes to 400 million dollars in sales globally every year. It is a nonessential amino acid that helps to improve an athlete's performance during short-term, high intensity exercises such as weightlifting. Supplementation of creatine increases skeletal muscle creatine levels, this boosts performance by increasing the rate at which 598:, the most commonly used substance by athletes, can be used for cardiovascular improvements though has significant detrimental effects. Ethanol was formerly banned by WADA during performance for athletes performing in aeronautics, archery, automobile, karate, motorcycling and powerboating, but was taken off the ban list in 2017. It is detected by 2580:
The results of this meta-analysis cannot address the important issues of individual differences in stimulant effects or the role of motivational enhancement in helping perform academic or occupational tasks. However, they do confirm the reality of cognitive enhancing effects for normal healthy adults
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Studies show that adolescent males who engage with fitness magazines are twice as likely to use performance-enhancing substances. Adolescents who partake in competitive sports are at a particularly high risk, with those involved in gridiron football, basketball, wrestling, baseball, and gymnastics at
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In 1980, Chandler and Blair showed significant increases in knee extension strength, acceleration, anaerobic capacity, time to exhaustion during exercise, pre-exercise and maximum heart rates, and time to exhaustion during maximal oxygen consumption (VO2 max) testing after administration of 15 mg of
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Physical fatigue has classically been attributed to peripheral factors within the muscle (Fitts, 1996), the depletion of muscle glycogen (Bergstrom & Hultman, 1967) or increased cardiovascular, metabolic, and thermoregulatory strain (Abbiss & Laursen, 2005; Meeusen et al., 2006b). In recent
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Aside from accounting for the reduced performance of mentally fatigued participants, this model rationalizes the reduced RPE and hence improved cycling time trial performance of athletes using a glucose mouthwash (Chambers et al., 2009) and the greater power output during a RPE matched cycling time
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Actoprotectors or synthetic adaptogens are compounds that enhance an organism's resilience to physical stress without increasing heat output. Actoprotectors are distinct from other doping compounds in that they increase physical and psychological resilience via non-exhaustive action. Actoprotectors
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In the 20th century, testosterone was isolated and characterized by scientists. In 1941, the first record of synthesized testosterone use occurred when a horse was given testosterone which successfully improved its race performance. Sports trainers soon after began advocating for testosterone use.
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Cognitive enhancement can be defined as the use of drugs and/or other means with the aim to improve the cognitive functions of healthy subjects in particular memory, attention, creativity and intelligence in the absence of any medical indication. ... The first aim of this paper was to review
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Manipulations of dopaminergic signaling profoundly influence interval timing, leading to the hypothesis that dopamine influences internal pacemaker, or "clock," activity. For instance, amphetamine, which increases concentrations of dopamine at the synaptic cleft advances the start of responding
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The present meta-analysis was conducted to estimate the magnitude of the effects of methylphenidate and amphetamine on cognitive functions central to academic and occupational functioning, including inhibitory control, working memory, short-term episodic memory, and delayed episodic memory. In
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Adolescents are the most vulnerable group when it comes to taking performance-enhancing substances. This is in part due to the significance placed on physical appearance by this age group as well as feelings of invincibility combined with a lack of knowledge surrounding long-term consequences.
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Ergogenic aids, or athletic performance-enhancing substances, include a number of drugs with various effects on physical performance. Drugs such as amphetamine and methylphenidate increase power output at constant levels of perceived exertion and delay the onset of fatigue, among other
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had consumed a diet consisting of dried figs which was a significant factor in winning the 200-yard stade race. Ancient Greek athletes at the time also incorporated stimulants such as wine and brandy into their training routines. Stimulants derived from plants (e.g.,
439:. Despite its small window for detection, two primary methods of testing have been developed for hGH, one being an isoform test which detects changes in growth hormone structure in the blood, and the markers test, which detects changes in serum protein ratios. 398:, thereby increasing maximal power output. Potential side effects include gastrointestinal cramps, weight gain, fatigue, and diarrhea. Creatine is currently not recognized as a prohibited substance and can be purchased as a legal dietary supplement. 1088:
current trends in the misuse of smart drugs (also known as Nootropics) presently available on the market focusing in detail on methylphenidate, trying to evaluate the potential risk in healthy individuals, especially teenagers and young adults.
415:: endogenous hormone that can help decrease fat mass while increasing lean body mass. hGH is one of the most commonly used substances among professional athletes because it has a small window for detection. It works by promoting the release of 459:
was that "The principle of an adaptogenic action needs further clarification and studies in the pre-clinical and clinical area. As such, the term is not accepted in pharmacological and clinical terminology that is commonly used in the EU."
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during interval timing, whereas antagonists of D2 type dopamine receptors typically slow timing;... Depletion of dopamine in healthy volunteers impairs timing, while amphetamine releases synaptic dopamine and speeds up timing.
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with massive muscles began circulating which further perpetuated a desire among athletes to use testosterone. In 1967, the first prohibited substance list and anti-doping measures were implemented at the 1968 Olympics.
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to criminalize the distribution and possession of non-medical anabolic steroids. In 1999, WADA was formed to address the escalating use of substances in sports, particularly after the 1998 doping scandal in cycling.
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Adaptogens are plants that support health through nonspecific effects, neutralize various environmental and physical stressors while being relatively safe and free of side effects. As of 2008, the position of the
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which increases the delivery of oxygen to muscles. It is commonly used among endurance athletes such as cyclists. It functions by protecting red blood cells against destruction whilst simultaneously stimulating
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Anabolic steroids are synthetically derived from testosterone and modified to have greater anabolic effects. They work by increasing the concentration of nitrogen in the muscle which inhibits catabolic
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Blood doping agents increase the oxygen-carrying capacity of blood beyond the individual's natural capacity. They are used in endurance sports like long-distance running, cycling, and Nordic skiing.
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Amphetamines and caffeine are stimulants that increase alertness, improve focus, decrease reaction time, and delay fatigue, allowing for an increased intensity and duration of training ...
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is popularly used in reference to anabolic steroids or their precursors (hence the colloquial term "steroids"); anti-doping organizations apply the term broadly. Agencies such as the WADA and
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supplements) are virtually never classified as performance enhancers despite their effects on performance. As is usual with categorization, there are borderline cases;
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trial following amphetamine ingestion (Swart, 2009). ... Dopamine stimulating drugs are known to enhance aspects of exercise performance (Roelands et al., 2008)
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were developing, PEDs saw an increase in use. Supplements were now exclusively being used to enhance muscular work capacity. The main stimulants being used included
281:) also promote mental and athletic performance, as cognitive enhancers and ergogenic aids respectively, by improving muscle strength and endurance while decreasing 1595:
Roelands B, de Koning J, Foster C, Hettinga F, Meeusen R (May 2013). "Neurophysiological determinants of theoretical concepts and mechanisms involved in pacing".
3287:"Relationships between body image, nutritional supplement use, and attitudes towards doping in sport among adolescent boys: implications for prevention programs" 1118: 285:
and fatigue. Stimulants are commonly used in lengthy exercises that require short bursts (e.g., tennis, team sports, etc.). Stimulants work by increasing
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method, orally, or through injection. Injectable forms of the steroid are the most potent and long-lasting. In general, potential side effects include:
3026:"Dehydroepiandrosterone (DHEA) is an anabolic steroid like dihydrotestosterone (DHT), the most potent natural androgen, and tetrahydrogestrinone (THG)" 1022: • Amphetamines increase dopamine/norepinephrine release and inhibit their reuptake, leading to central nervous system (CNS) stimulation 738:
in 2005 became classified as a controlled substance by WADA, however DHEA can still be obtained legally as an over-the-counter nutritional supplement.
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is banned at all times for an athlete by WADA, though performance-enhancing effects have yet to be studied. Cannabis and nicotine are detected through
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Koncic MZ, Tomczyk M (August 2013). "New insights into dietary supplements used in sport: active substances, pharmacological and side effects".
406:, a metabolite of leucine also used as a supplement, has positive effects on lean muscle mass, possibly through a decrease in muscle catabolism. 688:
Gene doping agents are a relatively recently described class of athletic performance-enhancing substances. These drug therapies, which involve
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Nootropics, or "cognition enhancers", are substances that are claimed to benefit overall cognition by improving memory (e.g., increasing
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and increase endogenous testosterone. The desired effects of steroid precursors however, are often not seen as they do not bind well to
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binding to muscle. This ultimately prohibits the breakdown of muscle and preserves muscle mass. Examples of anabolic steroids include:
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While the use of PEDs has expanded in recent times, the practice of using substances to improve performance has been around since the
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The classifications of substances as performance-enhancing substances are not entirely clear-cut and objective. As in other types of
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have been used to prepare athletes and enhance performance in Olympic competition. However, only bromantane has been placed on the
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which require steady hands and accurate aim, and also to overcome excessive nervousness or discomfort for more dangerous sports.
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try to prevent athletes from using these drugs by performing drug tests. When medical exemptions are granted they are called
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to epitestosterone glucuronide, which should be 3:1. Any ratio of 4:1 or greater is considered a positive test. The 1988
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Holt RI, Erotokritou-Mulligan I, Sönksen PH (August 2009). "The history of doping and growth hormone abuse in sport".
2540:"Prescription Stimulants' Effects on Healthy Inhibitory Control, Working Memory, and Episodic Memory: A Meta-analysis" 1643:"Is it time to turn our attention toward central mechanisms for post-exertional recovery strategies and performance?" 419:, insulin-like growth factor, the release of which has anabolic effects on the body. Potential side effects include: 2085:
Momaya A, Fawal M, Estes R (April 2015). "Performance-enhancing substances in sports: a review of the literature".
1049:"Smart drugs and synthetic androgens for cognitive and physical enhancement: revolving doors of cosmetic neurology" 893: 878: 847: 629: 379: 337:. Some stimulants are allowed in competitive sports and are widely accessible, though may also be monitored by the 1308:
van Amsterdam J, Opperhuizen A, Hartgens F (June 2010). "Adverse health effects of anabolic–androgenic steroids".
3831: 2806:"Erythropoietin as a performance-enhancing drug: Its mechanistic basis, detection, and potential adverse effects" 1435:
Parr JW (July 2011). "Attention-deficit hyperactivity disorder and the athlete: new advances and understanding".
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Prendergast HM, Bannen T, Erickson TB, Honore KR (March 2003). "The toxic torch of the modern Olympic Games".
2423:"The pharmacology of actoprotectors: practical application for improvement of mental and physical performance" 3917: 873: 3892: 734:. These steroids have little desired effect compared to anabolic steroids, but have the same side effects. 212: 913: 3907: 811: 633: 248: 2861:"Detection of EPO doping and blood doping: the haematological module of the Athlete Biological Passport" 3912: 851: 362:
also increases power output at constant levels of perceived exertion, but only during short term use.
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Albano GD, Amico F, Cocimano G, Liberto A, Maglietta F, Esposito M, et al. (19 January 2021).
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Better Fighting Through Chemistry? The Role of FDA Regulation in Crafting the Warrior of the Future
484: 436: 338: 244: 168: 160: 48:, can be used to improve athletic performance and build muscle, which in most cases is considered 3965: 3950: 3882: 2688:"Red blood cells in sports: effects of exercise and training on oxygen supply by red blood cells" 1024: • Amphetamines seem to enhance athletic performance in anaerobic conditions 39 40 723: 659: 3902: 3024:
Labrie F, Luu-The V, Martel C, Chernomoretz A, Calvo E, Morissette J, et al. (July 2006).
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Frati P, Kyriakou C, Del Rio A, Marinelli E, Vergallo GM, Zaami S, et al. (January 2015).
731: 391: 3091:"Oral andro-related prohormone supplementation: do the potential risks outweigh the benefits?" 2395:. European Medicines Agency Committee on Herbal Medicinal Products. 8 May 2008. Archived from 936:"The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance" 3473:"A review of designer anabolic steroids in equine sports: Designer steroids in equine sports" 863: 747: 549: 395: 3955: 1535:"Office of Dietary Supplements – Dietary Supplements for Exercise and Athletic Performance" 883: 371: 255:
both deemed anabolic steroids as an illegal substance when not used for disease treatment.
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Kitagawa H, Hisatsune J, Ohge H, Kutsuno S, Hara T, Masuda K, et al. (July 2021).
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Freeman ER, Bloom DA, McGuire EJ (February 2001). "A brief history of testosterone".
3413: 3362: 3318: 3260: 3229: 3194: 3167: 3159: 3118: 3110: 3063: 3055: 2995: 2987: 2945: 2927: 2888: 2880: 2833: 2825: 2786: 2768: 2727: 2709: 2669: 2657: 2649: 2559: 2512: 2504: 2460: 2442: 2438: 2371: 2336: 2328: 2284: 2266: 2227: 2209: 2170: 2152: 2102: 2038: 2030: 1983: 1975: 1936: 1918: 1864: 1831: 1790: 1772: 1725: 1717: 1674: 1612: 1568: 1512: 1452: 1410: 1406: 1379: 1325: 1290: 1272: 1203: 1178: 1078: 1009: 967: 719: 506: 204: 200: 81: 45: 3075: 3007: 2571: 2524: 2307:"Growth hormone doping in sports: a critical review of use and detection strategies" 2114: 1995: 1876: 1737: 1624: 3721: 3713: 3669: 3661: 3615: 3607: 3539: 3516: 3494: 3484: 3445: 3403: 3393: 3352: 3308: 3298: 3221: 3149: 3102: 3045: 3037: 2979: 2935: 2919: 2872: 2845: 2817: 2776: 2763: 2758: 2717: 2699: 2639: 2551: 2494: 2450: 2434: 2363: 2318: 2274: 2258: 2217: 2201: 2160: 2144: 2094: 2022: 1967: 1926: 1910: 1854: 1780: 1764: 1709: 1664: 1654: 1604: 1502: 1492: 1444: 1402: 1369: 1359: 1317: 1280: 1262: 1168: 1160: 1068: 1060: 1001: 957: 947: 888: 807: 670:
or stroke. Per the WADA, it is a banned substance. Urine samples can be tested via
435:. If not prescribed by a professional, it is a banned substance in competition per 180: 113: 77: 3837: 3871: 3341:"Doping in sports and its spread to at-risk populations: an international review" 837: 779: 735: 671: 607: 302: 278: 220: 184: 53: 3041: 2367: 1321: 992:
Liddle DG, Connor DJ (June 2013). "Nutritional supplements and ergogenic AIDS".
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Burnat P, Payen A, Le Brumant-Payen C, Hugon M, Ceppa F (27 September 1997).
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Breenfeldt Andersen A, Nordsborg NB, Bonne TC, Bejder J (26 December 2022).
2010: 1955: 1697: 1104: 952: 96:, for example, is considered a performance enhancer by some but not others. 3868: 3735: 3683: 3629: 3551: 3508: 3457: 3417: 3366: 3322: 3264: 3248: 3233: 3198: 3171: 3122: 3067: 2999: 2949: 2892: 2837: 2790: 2731: 2661: 2563: 2464: 2375: 2340: 2288: 2231: 2174: 2106: 2042: 1987: 1940: 1868: 1794: 1729: 1678: 1616: 1572: 1516: 1456: 1383: 1329: 1294: 1207: 1182: 1082: 1013: 971: 795: 775: 715: 689: 650:
Erythropoietin, or EPO, is a hormone that helps increase the production of
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Allows performance beyond the usual pain threshold. Some painkillers raise
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in general, while also indicating that these effects are modest in size.
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The phrase has been used to refer to several distinct classes of drugs:
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by organized athletic organizations. This usage is often referred to as
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Saugy M, Robinson N, Saudan C, Baume N, Avois L, Mangin P (July 2006).
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Substance used to improve any form of activity performance in humans
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Schumacher YO, Saugy M, Pottgiesser T, Robinson N (November 2012).
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Levy JL, Cabrera J, Thomas S, Brennan FH (2008). "Ergogenic Aids".
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is the only indirect testing method for detection of blood doping.
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Stimulants improve focus and alertness. Low (therapeutic) doses of
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Parker KL, Lamichhane D, Caetano MS, Narayanan NS (October 2013).
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Delbeke FT, Van Eenoo P, Van Thuyne W, Desmet N (December 2002).
2628:"Contemporary blood doping—Performance, mechanism, and detection" 1641:
Rattray B, Argus C, Martin K, Northey J, Driller M (March 2015).
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to produce more red blood cells. Potential side effects include:
632:(rhEPO) is one of the most widely known drugs in this class. The 595: 583: 342: 330: 89: 2965: 2480: 1478: 1307: 3826: 3211: 3184: 3023: 2804:
Salamin O, Kuuranne T, Saugy M, Leuenberger N (15 March 2018).
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performance enhancers are universally classified as such (like
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Eidelsberg J (June 1946). "Testosterone pellet implantation".
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Pesta DH, Angadi SS, Burtscher M, Roberts CK (December 2013).
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Cappelletti S, Daria P, Sani G, Aromatario M (January 2015).
1046: 553: 416: 3593: 3564: 2908:"Genetics and the Elite Athlete: Our Understanding in 2020" 1032: • Increased alertness and attention to task 933: 666:
and an increase in blood viscosity which could result in a
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International Journal of Sports Physiology and Performance
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Ganesan K, Rahman S, Zito PM (2024). "Anabolic Steroids".
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The Journal of Steroid Biochemistry and Molecular Biology
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The Journal of Steroid Biochemistry and Molecular Biology
1640: 60:. Cognitive performance-enhancing drugs, commonly called 3797: 3291:
Journal of the International Society of Sports Nutrition
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Scandinavian Journal of Medicine & Science in Sports
2190:"Insulin-like growth factor 1 (IGF-1): a growth hormone" 2130: 2080: 2078: 2076: 2074: 1847:
Scandinavian Journal of Medicine & Science in Sports
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Also known as anabolic steroid precursors, they promote
203:. Potential side effects specifically in males include: 2058:"What Do Athletes Need to Know About Creatine? | USADA" 1222:"Performance Enhancing Anabolic Steroid Abuse in Women" 2745:
Bhoopalan SV, Huang LJ, Weiss MJ (18 September 2020).
2011:"Side effects of creatine supplementation in athletes" 1840: 810:. In 1988, the United States Congress established the 714:. Once in the body, these precursors are converted to 2594:""No need for laboratory to test for alcohol" – WADA" 2247:"The Use and Abuse of Human Growth Hormone in Sports" 2071: 1467: 914:"Effects of Performance-Enhancing Drugs | USADA" 3532:
The Journal of Clinical Endocrinology and Metabolism
3338: 1843:"Neurophysiological effects of exercise in the heat" 1558: 3867: 3435: 2744: 696:, are not known to currently be in use as of 2020. 239:, and thickening of vocal cords (voice deepening). 3379: 2905: 1698:"Considerations in the Use of Stimulants in Sport" 582:Sedatives and anxiolytics are used in sports like 223:. Potential side specifically in females include: 3135: 2621: 2619: 2617: 2615: 2008: 1896: 1195: 548:. Painkillers used by athletes range from common 3942: 2084: 1590: 1588: 309:. Potential side effects include: hypertension, 3650:"Performance-Enhancing Drug Use in Adolescence" 2537: 1897:Butts J, Jacobs B, Silvis M (23 October 2017). 1567:, Treasure Island (FL): StatPearls Publishing, 3567:"What is the history of anabolic steroid use?" 3339:Baron DA, Martin DM, Abol Magd S (June 2007). 3284: 3249:"Doping in sports in ancient and recent times" 2612: 1841:Roelands B, De Pauw K, Meeusen R (June 2015). 1430: 1428: 1426: 3853: 3699: 3136:Brown GA, Vukovich M, King DS (August 2006). 2390:"Reflection Paper on the Adaptogenic Concept" 2353: 1695: 1585: 1248: 1042: 1040: 3470: 2347: 991: 987: 985: 983: 981: 567: 3142:Medicine and Science in Sports and Exercise 1423: 929: 927: 925: 923: 135:. Anabolic steroids can be taken through a 3860: 3846: 3647: 3529: 2906:John R, Dhillon MS, Dhillon S (May 2020). 2538:Ilieva IP, Hook CJ, Farah MJ (June 2015). 2244: 2055: 2009:Francaux M, Poortmans JR (December 2006). 1037: 674:, and blood samples via indirect markers. 505:capacity or updating) or other aspects of 3725: 3673: 3619: 3498: 3488: 3407: 3397: 3356: 3312: 3302: 3153: 3049: 2939: 2780: 2762: 2721: 2703: 2685: 2643: 2498: 2454: 2420: 2322: 2278: 2221: 2164: 1930: 1858: 1784: 1668: 1658: 1506: 1496: 1373: 1363: 1284: 1266: 1172: 1072: 978: 961: 951: 3471:Waller CC, McLeod MD (12 October 2016). 1559:Farzam K, Faizy RM, Saadabadi A (2022), 1030: • Increased acceleration 1026: • Improved reaction time 920: 358:athletic-performance-enhancing effects; 3088: 2304: 1953: 1249:Reardon CL, Creado S (14 August 2014). 14: 3943: 3750:"Performance-Enhancing Drug Resources" 3654:American Journal of Lifestyle Medicine 3095:Canadian Journal of Applied Physiology 3019: 3017: 2961: 2959: 2681: 2679: 2476: 2474: 2300: 2298: 2133:"Human growth hormone doping in sport" 2126: 2124: 1892: 1890: 1808: 1806: 1804: 1341: 1339: 1310:Regulatory Toxicology and Pharmacology 1146: 1103:(Report). 8 March 2004. Archived from 3841: 3695: 3693: 3643: 3641: 3639: 3589: 3587: 3431: 3429: 3427: 3334: 3332: 3280: 3278: 3276: 3274: 3246: 3138:"Testosterone prohormone supplements" 2187: 1485:Frontiers in Integrative Neuroscience 1244: 1242: 289:levels and agonistic activity at the 243:are tested to determine the ratio of 2810:Molecular and Cellular Endocrinology 1434: 1142: 1140: 1020:Physiologic and performance effects 107: 3014: 2956: 2676: 2471: 2295: 2245:Siebert DM, Rao AL (October 2018). 2121: 1960:Molecular and Cellular Biochemistry 1887: 1801: 1399:The Sports Medicine Resource Manual 1336: 1149:"Pharmacology of anabolic steroids" 24: 3898:Ergogenic use of anabolic steroids 3700:Dandoy C, Gereige RS (June 2012). 3690: 3636: 3584: 3565:National Institute on Drug Abuse. 3523: 3424: 3380:Knechtle B, Nikolaidis PT (2018). 3373: 3329: 3271: 3155:10.1249/01.mss.0000228928.69512.2e 2421:Oliynyk S, Oh S (September 2012). 2137:British Journal of Sports Medicine 1696:Reardon CL, Factor RM (May 2016). 1255:Substance Abuse and Rehabilitation 1239: 869:Ergogenic use of anabolic steroids 767:to overcome injuries and fatigue. 750:. In the Olympic Games of 668 BC, 722:. Examples of prohormones include 293:. Examples of stimulants include: 84:), whereas other substances (like 25: 3977: 3819: 3798:"U.S. Anti-Doping Agency – USADA" 3214:Growth Hormone & IGF Research 2544:Journal of Cognitive Neuroscience 1769:10.2174/1570159X13666141210215655 1137: 1119:"Caffeine and Sports Performance" 1065:10.2174/1570159X13666141210221750 831: 802:In the 1980s, the main PEDs were 639: 617: 463: 352: 3825: 3648:White ND, Noeun J (March 2017). 3612:10.2169/internalmedicine.5579-20 3571:National Institute on Drug Abuse 3450:10.1097/00005392-200102000-00004 3285:Yager Z, O'Dea JA (March 2014). 2686:Mairbäurl H (12 November 2013). 2439:10.4062/biomolther.2012.20.5.446 1702:Sports Medicine (Auckland, N.Z.) 1407:10.1016/B978-141603197-0.10048-5 1121:. Vanderbilt.edu. Archived from 894:Steroid use in American football 879:List of drugs used by militaries 848:United States Anti-Doping Agency 630:Recombinant human erythropoietin 380:Beta-Hydroxy-Beta-methylbutyrate 31:Performance-enhancing substances 3930:Performance-enhancing substance 3802:U.S. Anti-Doping Agency (USADA) 3790: 3764: 3742: 3558: 3464: 3240: 3205: 3187:Veterinary and Human Toxicology 3178: 3129: 3082: 2899: 2852: 2797: 2738: 2586: 2483:"Bromontan, a new doping agent" 2427:Biomolecules & Therapeutics 2414: 2382: 2238: 2181: 2049: 2002: 1947: 1744: 1689: 1552: 1527: 1390: 1301: 1153:British Journal of Pharmacology 818: 2912:Indian Journal of Orthopaedics 2764:10.12688/f1000research.26648.1 1214: 1189: 1111: 1093: 906: 699: 677: 544:, increasing oxygen supply to 529: 13: 1: 3918:Masculinizing hormone therapy 3702:"Performance-enhancing drugs" 2984:10.1016/s0960-0760(02)00274-1 2500:10.1016/s0140-6736(05)63310-7 899: 874:List of doping cases in sport 732:dehydroepiandrosterone (DHEA) 524: 490: 443: 258: 67: 3712:(6): 265–271, quiz 271–272. 3089:Broeder CE (February 2003). 2056:Perishable (10 March 2021). 1954:Kreider RB (February 2003). 786:tablets made of cocaine and 770:In the late 19th century as 7: 3908:Transgender hormone therapy 3042:10.1016/j.jsbmb.2006.03.006 2368:10.2174/1389450111314090016 1322:10.1016/j.yrtph.2010.02.001 857: 844:performance-enhancing drugs 634:Athlete Biological Passport 560:) to powerful prescription 365: 35:performance-enhancing drugs 18:Performance enhancing drugs 10: 3982: 3913:Feminizing hormone therapy 3226:10.1016/j.ghir.2009.04.009 2924:10.1007/s43465-020-00056-z 2757:: F1000 Faculty Rev–1153. 1437:Clinics in Sports Medicine 940:Nutrition & Metabolism 852:therapeutic use exemptions 835: 741: 703: 681: 643: 621: 571: 533: 494: 467: 447: 403:β-hydroxy β-methylbutyrate 369: 262: 111: 3878: 3477:Drug Testing and Analysis 2865:Drug Testing and Analysis 2822:10.1016/j.mce.2017.01.033 2305:Baumann GP (April 2012). 2099:10.1007/s40279-015-0308-9 1757:Current Neuropharmacology 1714:10.1007/s40279-015-0456-y 1609:10.1007/s40279-013-0030-4 1449:10.1016/j.csm.2011.03.007 1365:10.3390/healthcare9010097 1202:. StatPearls Publishing. 1053:Current Neuropharmacology 1006:10.1016/j.pop.2013.02.009 763:, etc.) were used by the 568:Sedatives and anxiolytics 457:European Medicines Agency 161:high-density lipoproteins 44:Many substances, such as 3776:World Anti-Doping Agency 3666:10.1177/1559827616680593 3399:10.3389/fphys.2018.00634 2705:10.3389/fphys.2013.00332 2263:10.1177/1941738118782688 2188:Laron Z (October 2001). 2149:10.1136/bjsm.2006.027573 1915:10.1177/1941738117737248 1899:"Creatine Use in Sports" 1818:World Anti-Doping Agency 1660:10.3389/fphys.2015.00079 1498:10.3389/fnint.2013.00075 1251:"Drug abuse in athletes" 485:World Anti-Doping Agency 394:can be replenished from 339:World Anti-Doping Agency 245:testosterone glucuronide 99: 3883:Bodybuilding supplement 3386:Frontiers in Physiology 3304:10.1186/1550-2783-11-13 2968:"Prohormones and sport" 2692:Frontiers in Physiology 1972:10.1023/A:1022465203458 1647:Frontiers in Physiology 1147:Kicman AT (June 2008). 953:10.1186/1743-7075-10-71 3903:Growth hormone therapy 3438:The Journal of Urology 2598:www.insidethegames.biz 392:adenosine triphosphate 2027:10.1123/ijspp.1.4.311 1814:"The Prohibited List" 864:Cosmetic pharmacology 748:Ancient Olympic Games 594:are common examples. 396:adenosine diphosphate 205:male pattern baldness 3893:Clitoris enlargement 3834:at Wikimedia Commons 3718:10.1542/pir.33-6-265 3706:Pediatrics in Review 3544:10.1210/jcem-6-6-423 2556:10.1162/jocn_a_00776 2402:on 20 September 2018 2356:Current Drug Targets 2324:10.1210/er.2011-1035 2143:(Suppl 1): i35–i39. 1401:. pp. 598–610. 1165:10.1038/bjp.2008.165 884:Natural bodybuilding 842:In sports, the term 411:Human Growth Hormone 372:Human growth hormone 349:, ephedrine, etc.). 291:adrenergic receptors 253:Anabolic Steroid Act 213:prostate hypertrophy 153:elevated cholesterol 3253:Medicina Nei Secoli 2206:10.1136/mp.54.5.311 2194:Molecular Pathology 1125:on 29 February 2012 1107:on 3 February 2016. 812:Anti-Drug Abuse Act 515:attentional control 275:reuptake inhibitors 249:Anti-Drug Abuse Act 3888:Breast enlargement 3778:. 14 November 2013 1853:(Suppl 1): 65–78. 1268:10.2147/SAR.S53784 720:androgen receptors 668:pulmonary embolism 552:medicines such as 511:inhibitory control 273:stimulants (e.g., 217:testicular atrophy 177:peliosis hepatitis 141:muscle hypertrophy 3938: 3937: 3925:Penis enlargement 3830:Media related to 3752:. Drug Free Sport 3606:(14): 2337–2340. 3600:Internal Medicine 3247:Conti AA (2010). 2645:10.1111/sms.14243 2493:(9082): 963–964. 2311:Endocrine Reviews 1860:10.1111/sms.12350 1416:978-1-4160-3197-0 808:anabolic steroids 724:norandrostendione 507:cognitive control 333:, addiction, and 169:hepatic carcinoma 108:Anabolic steroids 82:anabolic steroids 46:anabolic steroids 16:(Redirected from 3973: 3862: 3855: 3848: 3839: 3838: 3829: 3813: 3812: 3810: 3808: 3794: 3788: 3787: 3785: 3783: 3768: 3762: 3761: 3759: 3757: 3746: 3740: 3739: 3729: 3697: 3688: 3687: 3677: 3645: 3634: 3633: 3623: 3591: 3582: 3581: 3579: 3577: 3562: 3556: 3555: 3527: 3521: 3520: 3502: 3492: 3490:10.1002/dta.2112 3483:(9): 1304–1319. 3468: 3462: 3461: 3433: 3422: 3421: 3411: 3401: 3377: 3371: 3370: 3360: 3345:World Psychiatry 3336: 3327: 3326: 3316: 3306: 3282: 3269: 3268: 3259:(1–3): 181–190. 3244: 3238: 3237: 3209: 3203: 3202: 3182: 3176: 3175: 3157: 3148:(8): 1451–1461. 3133: 3127: 3126: 3086: 3080: 3079: 3053: 3021: 3012: 3011: 2978:(1–5): 245–251. 2963: 2954: 2953: 2943: 2903: 2897: 2896: 2856: 2850: 2849: 2801: 2795: 2794: 2784: 2766: 2742: 2736: 2735: 2725: 2707: 2683: 2674: 2673: 2647: 2638:(1): sms.14243. 2623: 2610: 2609: 2607: 2605: 2600:. 5 October 2017 2590: 2584: 2583: 2550:(6): 1069–1089. 2535: 2529: 2528: 2502: 2478: 2469: 2468: 2458: 2418: 2412: 2411: 2409: 2407: 2401: 2394: 2386: 2380: 2379: 2362:(9): 1079–1092. 2351: 2345: 2344: 2326: 2302: 2293: 2292: 2282: 2242: 2236: 2235: 2225: 2185: 2179: 2178: 2168: 2128: 2119: 2118: 2082: 2069: 2068: 2066: 2064: 2053: 2047: 2046: 2006: 2000: 1999: 1951: 1945: 1944: 1934: 1894: 1885: 1884: 1862: 1838: 1829: 1828: 1826: 1824: 1810: 1799: 1798: 1788: 1748: 1742: 1741: 1693: 1687: 1686: 1672: 1662: 1638: 1629: 1628: 1592: 1583: 1582: 1581: 1579: 1556: 1550: 1549: 1547: 1545: 1531: 1525: 1524: 1510: 1500: 1476: 1465: 1464: 1432: 1421: 1420: 1394: 1388: 1387: 1377: 1367: 1343: 1334: 1333: 1305: 1299: 1298: 1288: 1270: 1246: 1237: 1236: 1234: 1232: 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atrophy 221:prostate cancer 116: 110: 102: 70: 28: 23: 22: 15: 12: 11: 5: 3979: 3969: 3968: 3966:Ergogenic aids 3963: 3958: 3953: 3951:Drugs in sport 3936: 3935: 3933: 3932: 3927: 3922: 3921: 3920: 3915: 3905: 3900: 3895: 3890: 3885: 3879: 3876: 3875: 3865: 3864: 3857: 3850: 3842: 3836: 3835: 3832:Ergogenic aids 3821: 3820:External links 3818: 3815: 3814: 3789: 3763: 3741: 3689: 3660:(2): 122–124. 3635: 3583: 3557: 3538:(6): 423–425. 3522: 3463: 3444:(2): 371–373. 3423: 3372: 3351:(2): 118–123. 3328: 3270: 3239: 3220:(4): 320–326. 3204: 3177: 3128: 3101:(1): 102–116. 3081: 3036:(1–3): 52–58. 3013: 2955: 2918:(3): 256–263. 2898: 2851: 2796: 2737: 2675: 2611: 2585: 2530: 2470: 2433:(5): 446–456. 2413: 2381: 2346: 2317:(2): 155–186. 2294: 2257:(5): 419–426. 2237: 2200:(5): 311–316. 2180: 2120: 2093:(4): 517–531. 2070: 2048: 2021:(4): 311–323. 2001: 1966:(1–2): 89–94. 1946: 1886: 1830: 1800: 1743: 1708:(5): 611–617. 1688: 1630: 1603:(5): 301–311. 1584: 1551: 1539:ods.od.nih.gov 1526: 1466: 1443:(3): 591–610. 1422: 1415: 1389: 1335: 1316:(1): 117–123. 1300: 1238: 1213: 1188: 1159:(3): 502–521. 1136: 1110: 1092: 1036: 1000:(2): 487–505. 977: 919: 904: 903: 901: 898: 897: 896: 891: 886: 881: 876: 871: 866: 859: 856: 836:Main article: 833: 832:Usage in sport 830: 820: 817: 743: 740: 728:androstenediol 712:lean body mass 704:Main article: 701: 698: 682:Main article: 679: 676: 646:Erythropoietin 644:Main article: 641: 640:Erythropoietin 638: 622:Main article: 619: 618:Blood boosters 616: 612:urine analysis 569: 566: 542:blood pressure 534:Main article: 531: 528: 526: 523: 519:attention span 503:working memory 495:Main article: 492: 489: 468:Main article: 465: 464:Actoprotectors 462: 448:Main article: 445: 442: 441: 440: 421:cardiomyopathy 407: 399: 367: 364: 354: 353:Ergogenic aids 351: 263:Main article: 260: 257: 237:breast atrophy 121:glucocorticoid 112:Main article: 109: 106: 101: 98: 74:categorization 69: 66: 58:ergogenic aids 26: 9: 6: 4: 3: 2: 3978: 3967: 3964: 3962: 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Index

Performance enhancing drugs
anabolic steroids
cheating
"doping"
nootropics
categorization
prototype
anabolic steroids
vitamins
protein
caffeine
Anabolic steroid
glucocorticoid
oxandrolone
stanozolol
nandrolone
transdermal
muscle hypertrophy
acne
hypertension
elevated cholesterol
thrombosis
high-density lipoproteins
libido
hepatic carcinoma
cholestasis
peliosis hepatitis
septic arthritis
Wilm's tumor
psychosis

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