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333:). He continued to study peripheral nerve demyelinization and membrane structures. Using enzyme histochemical methods, he and his coworkers were able to prove that changes in ion concentrations can induce phase changes in cell membranes. Another study dealt with the substance (or substances) called amyloid (Wolman 1971).
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in 1985 and despite being formally retired remained active and remained a continued source of knowledge and wisdom well into his eighties. His opening remarks in his Pearse Prize
Lecture show the wisdom of a great scientist, “…after all, our scientific work is amply rewarded by the clear moments when
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Wolman was a member of the
Histochemical Society (USA), the Society for Experimental Biology and Medicine and the Israel Association of Pathologists and the Gesellschaft fur Histochemie. In 1966, he was elected as a member of the Deutsche Akademie der Naturforscher Leopoldina. In 1984, he founded the
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Wolman also studied chemical factors underlying various impregnation procedures for the nervous system. He was also involved in research on demyelination of peripheral nerve sheaths and also showed that black osmium staining light microscopy and its electron density for electron microscopy, appears
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in
Jerusalem and was involved in histochemical research. He taught at the newly founded Medical School of the Hebrew University. In this period, he studied the chemical significance of the periodic acid-Schiff (PAS) staining method and showed that the method is not specific for carbohydrates as was
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back to occupied
Ethiopia and was in charge of a medical ward and clinical laboratory in the Menelik Hospital in Addis Ababa in 1941-1944. In 1944, he was posted in the Central Pathology Laboratory of the Middle East Forces located in Cairo, Egypt. In 1945 he was appointed as head of the Pathology
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In 1951 his research included histochemistry of viral and non-viral inclusion bodies and he continued to study chemical fixatives and fixation techniques. He showed that proteoglycans and polysaccharides of different pK values in their end groups can be differently stained which resulted in the
401:(Wolman, 1989) and also received the Pioneer Award of the International Federation of Histochemical Societies (Carpenter, 1990). In 2000, an annual Wolman lecture was inaugurated by the Israel Society for Histochemistry and Cytochemistry. He was appointed emeritus professor of the
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in routine pathology and diagnostic molecular research. He was one of the first to recognize that polarized light microscopy is a powerful tool, which allows the detection of structures that otherwise be obtained only with great difficulty (Wolman, 1970).
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From 1938 to 1940, he worked in the Cancer
Research Institute of the Hebrew University and did residency at the department of Internal Medicine of the Hadassah Hospital. In the 1940s, he volunteered to serve in the
381:. He was concerned with the issues of medical errors and published a book on the subject together with his daughter, Ruth Manor, "Doctor's Errors and Mistakes of Medicine: Must Health Care Deteriorate?" (2004).
326:) and its importance in myelin breakdown. His research was focused on the oxidation of lipids, the formation of lipid peroxides, their polymerization, and the pathogenesis and nature of lipid pigments.
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Understanding of the chemistry involved in histological techniques enabled Moshe Wolman in the 1950s to determine that the storage disease, that was later named after him is known as
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Wolman authored more than 200 publications and contributions to books. Over the years, he contributed chapters to many textbooks and served on numerous editorial boards including
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first in carbohydrates before it stains unsaturated lipids. He also demonstrated the presence of a carbohydrate-containing moiety in myelin (later shown by others to be different
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development of Bi-Col procedure (Wolman, 1956). In fact, advances in our understanding of the chemical nature of ground substance remained largely neglected for a generation.
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Doctors' Errors and
Mistakes of Medicine: Must Health Care Deteriorate? (Biomedical and Health Research, Volume 59) by Moshe Wolman and Ruth Manor (Hardcover - Jun 1, 2004)
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He was deeply interested in educational and ethical questions. He published a book on ethics and demagoguery and served as chairperson of the ethics committee of the
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A histochemical method for the differential staining of acidic tissue components (particularly ground-substance polysaccharides), Bull Res
Council Israel. 1956
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Macrophages and their acid esterase in atherosclerosis. Pearse Prize
Lecture Speech delivered 5 January 1988) Pro Roy Microsc Soc. 1989
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In 1959, Wolman was appointed head of the
Department of Pathology of the Tel Hashomer Government Hospital (later renamed as the
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Biological peroxidation of lipids and membranes (Israel journal of medical sciences) by Moshe Wolman (Unknown
Binding - 1975)
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The Healing and Scarring of Atheroma (Advances in Experimental Medicine and Biology) by Moshe Wolman (Hardcover - Feb 1984)
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344:, is caused by accumulation in cells of a mixture of cholesterol and triglycerides and differed substantially from
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The Healing and Scarring of Atheroma. Advances in Experimental Medicine and Biology, New York, 1984, volume 168.
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Histochemistry of lipids in pathology (Handbuch der Histochemie) by Moshe Wolman (Unknown Binding - 1964)
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260:, 1935–1938). In 1939, he married Brigitte "Bigi" Koebbel with whom he had four children: filmmaker
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Histochemistry and lipids in pathology. Handbuch of Histochemie. Fischer, Stuttgart, Germany. 1964
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After his release from the army in 1946, Wolman joined the department of Pathology of the
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Wolman was the first recipient of the Pearse Prize for Histochemistry awarded by the
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complex and difficult problems become simple and understandable” (Wolman, 1989).
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In 1964, Wolman was appointed full professor and head of the Department of
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In 2002, Coleman attributed the enormous progress in the development of
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Doctors' Errors and Mistakes of Medicine: Must Health Care Deteriorate?
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An experiment in teaching histology and cell biology, Med Teacher. 1985
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Biological peroxidation of lipids and membranes, Israel J Med Sci. 1975
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in Israel to the "pioneering research and wisdom of Moshe Wolman."
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On the Use of polarized microscopy in pathology, Pathol Annu. 1970
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Pigments in Pathology by Moshe Wolman (Hardcover - Jan 1, 1969)
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Amyloid, its nature and molecular structure, Lab Invest. 1971
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252:(academic secondary school). He studied medicine in Italy (
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Pigments in Pathology, Academic Press, New York, NY. 1969
220:(November 10, 1914 – September 5, 2009) was an Israeli
508:"Professor Moshe Wolman: pioneer in histochemistry"
51:. Unsourced material may be challenged and removed.
461:Lipid pigments, Fischer, Stuttgart, Germany. 1993
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289:and joined the 101 Military Mission (the famous
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314:thought at the time, but also stains lipids.
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302:Laboratory of the 27th General Hospital in
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111:Learn how and when to remove this message
394:and served as its president until 1990.
351:Wolman formulated the theory and use of
635:Polish emigrants to Mandatory Palestine
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363:at the newly founded Medical School of
630:British Army personnel of World War II
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390:Israel Society for Histochemistry and
605:Academic staff of Tel Aviv University
573:"Organization: amsalemmedicalcenter"
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49:adding citations to reliable sources
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248:and graduated from the prestigious
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236:Moshe Wolman was born in 1914 in
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36:needs additional citations for
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379:Israel Medical Association
331:Chaim Sheba Medical Center
561:– via Google Books.
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272:Naomi Oren, and composer
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620:Israeli military doctors
16:Israeli neuropathologist
524:10.1078/0065-1281-00645
353:polarization microscopy
244:in 1925. He grew up in
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487:Health care in Israel
625:Israeli pathologists
346:Niemann–Pick disease
45:improve this article
403:Tel Aviv University
365:Tel Aviv University
207:, Naomi Oren &
600:Israeli scientists
348:. (Wolman, 1989).
250:Herzliya Gymnasium
640:Neuropathologists
512:Acta Histochemica
385:Awards and legacy
311:Hadassah Hospital
242:Mandate Palestine
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173:September 5, 2009
155:November 10, 1914
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291:Gideon Force
287:British Army
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274:Amnon Wolman
270:psychiatrist
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175:(2009-09-05)
139:Wolman, 1999
127:Moshe Wolman
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43:Please help
38:verification
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615:2009 deaths
610:1914 births
372:Histochemie
594:Categories
493:References
266:Ruth Manor
262:Dan Wolman
205:Ruth Manor
201:Dan Wolman
151:1914-11-10
71:newspapers
361:Pathology
306:, Egypt.
232:Biography
578:12 April
532:12086331
481:See also
254:Florence
246:Tel Aviv
196:Children
85:scholar
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238:Warsaw
188:Spouse
181:Israel
163:Poland
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