17:
87:) and 50 were spinal or located along spinal roots. The authors noted that the median age was 40 years for patients with intracranial tumors and 49 years for those with spinal tumors. The lesions were more common in women (57.9%). The review reported a recurrence rate of 26.3% and a mortality rate of 10.5% over a 46-month period.
43:
Histologically, the tumor is characterized by large, uniformly shaped polyhedral nevus cells that are pigmented and closely packed. Typically, it lacks signs of malignancy, such as a high mitotic rate, necrosis, or infiltrative growth. Similar to malignant melanoma, it exhibits an immunohistochemical
79:
of the brain, typically in the area of the base of the brain and brainstem, or the spine. Symptoms may be absent or related to the tumor's growth and location. Similar to optic melanocytomas, the main concerns include growth, recurrence, and malignant transformation. Meningeal melanocytomas account
896:
Wilcock B, Dubielzig R.R., Render J.A. Histological
Classification of Ocular and Otic Tumors of Domestic Animals. In: Schulman F.Y., editor. WHO International Histological Classification of Tumors of Domestic Animals. IX. Armed Forces Institute of Pathology; Washington, D.C.:
62:
as an optic melanocytoma. The lesion can be found at any age, and its location and size may lead to clinical symptoms. While melanocytomas are generally considered to be benign tumors, they have the potential for growth, recurrence, and transformation into
67:. Because malignant transformation is rare, optic melanocytomas can usually be managed with observation. Therefore, in asymptomatic patients, regular monitoring via fundoscopy is recommended, potentially supported by ocular ultrasonography.
628:
Lisker-Cervantes, Andrés; Ancona-Lezama, David Arturo; Arroyo-Garza, Luis Javier; Martinez, Jaime D.; Barreiro, Roberta Gomez Diaz; Valdepeña-López-Velarde, Victor Daniel; Morales-Canton, Virgilio; Moragrega-Adame, Eduardo (2017).
497:
Reidy, James J.; Apple, David J.; Steinmetz, Robert L.; Craythorn, Judy M.; Loftfield, Katherine; Gieser, Stephen C.; Brady, Steven E. (1985). "Melanocytoma: Nomenclature, pathogenesis, natural history and treatment".
770:
Rahimi-Movaghar, Vafa; Karimi, Mehrbod (2003). "Meningeal melanocytoma of the brain and oculodermal melanocytosis (nevus of Ota): case report and literature review".
136:
813:
Rades, Dirk; Heidenreich, Fedor; Tatagiba, Marcos; Brandis, Almuth; Karstens, Johann
Hinrich (2001). "Therapeutic options for meningeal melanocytoma".
478:
673:
Wang, F.; Li, X.; Chen, L.; Pu, X. (2007). "Malignant transformation of spinal meningeal melanocytoma. Case report and review of the literature".
90:
A 2001 review by Rades et al. concluded that complete resection is the best treatment option. If resection is incomplete, postoperative
285:
268:
106:, a condition that may present both diagnostic and therapeutic challenges. In the differential diagnosis, other conditions such as
927:
542:
Malignant transformation of optic disc melanocytoma? A clinical dilemma at presentation with a review of the literature.
710:"Primary meningeal melanocytoma of the cerebellopontine angle associated with ipsilateral nevus of Ota: A case report"
311:
Shanthi, Vissa; Ramakrishna, BA; Bheemaraju, Vydehi
Venkata; Rao, Nandam Mohan; Athota, Venkata Ramana Murthy (2010).
922:
269:"Meningeal melanocytoma ("melanotic meningioma"). Its melanocytic origin as revealed by electron microscopy"
373:
Mohmad, Zalilawati; Aik Kah, Tan; Chui Yong, Ku; Wan Abdul Halim, Wan
Haslina; Kong Yong, Then (2011).
912:
158:
Shields, Jerry A.; Demirci, Hakan; Mashayekhi, Arman; Eagle, Ralph C.; Shields, Carol L. (2006).
435:
Schindler CU, Kuchelmeister K, Richter HP, Schachenmayr W (1998). "Das meningeale
Melanozytom".
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Elazim, Ahmed Abd; Elbadry, Rasha; Mohamed, Kazim; Issa, Mamdouh; Ayyad, Ali (2018).
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83:
In a 2003 review of 95 cases by Rahimi-Movaghar et al., 45 were intracranial (mostly
53:
28:
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16:
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739:
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682:
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571:"Clinical imaging and high-resolution ultrasonography in melanocytoma management"
76:
858:"Unusual presentation of an anterior uveal melanocytoma in a 3-year-old poodle"
826:
208:
Sethi, Divya; Duhan, Amrita; Sen, Rajeev; Goyal, Vandana; Modi, Shilpi (2011).
906:
834:
791:
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10.1002/1097-0142(197211)30:5<1286::aid-cncr2820300522>3.0.co;2-v
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profile with S-100 protein-, vimentin-, and HMB-45-positive tumor cells.
587:
390:
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Melanocytomas have been described in animals, including dogs and cats.
111:
107:
27:
is a rare pigmented tumor that has been described as a variant of the
372:
35:. The term "melanocytoma" was introduced by Limas and Tio in 1972.
621:
75:
A meningeal melanocytoma is a rare, pigmented tumor found on the
812:
310:
102:
Pigmented tumors can raise concerns about the possibility of a
375:"Melanocytoma of the optic nerve head - a diagnostic dilemma"
157:
496:
58:
A melanocytoma most commonly occurs on or adjacent to the
707:
631:"Ocular ultrasound findings in optic disk melanocytoma"
313:"Spinal meningeal melanocytoma: A rare meningeal tumor"
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137:
Melanocytic tumors of uncertain malignant potential
765:
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207:
904:
203:
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114:with pigmentation should also be considered.
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477:: CS1 maint: multiple names: authors list (
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160:"Melanocytoma of the Optic Disk: A Review"
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317:Annals of Indian Academy of Neurology
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176:10.1016/j.survophthal.2005.12.011
714:Surgical Neurology International
635:Revista Mexicana de Oftalmología
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862:The Canadian Veterinary Journal
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210:"Spinal meningeal melanocytoma"
80:for 0.06-0.1% of brain tumors.
928:Melanocytic nevi and neoplasms
815:Journal of Neurosurgery: Spine
675:Journal of Neurosurgery: Spine
534:
260:
1:
784:10.1016/S0090-3019(02)01052-2
214:Asian Journal of Neurosurgery
142:
648:10.1016/j.mexoft.2017.03.003
548:216, 2002, S. 292–295.
512:10.1016/0039-6257(85)90107-9
38:
7:
569:Murray, Timothy G. (2010).
125:
10:
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827:10.3171/spi.2001.95.2.0225
51:
923:Nervous system neoplasia
687:10.3171/spi.2007.6.5.451
267:Limas C, Tio FO (1972).
31:and is derived from the
856:Martens, A. L. (2007).
500:Survey of Ophthalmology
330:10.4103/0972-2327.74192
227:10.4103/1793-5482.92176
164:Survey of Ophthalmology
727:10.4103/sni.sni_235_18
575:Clinical Ophthalmology
98:Differential diagnosis
71:Meningeal melanocytoma
20:
449:10.1007/s002920050292
52:Further information:
19:
540:P. M. Sharma u. a.:
379:Clinics and Practice
588:10.2147/OPTH.S11891
391:10.4081/cp.2011.e60
132:Dermal melanocytoma
118:Veterinary medicine
772:Surgical Neurology
104:malignant melanoma
65:malignant melanoma
48:Optic melanocytoma
21:
54:Optic nerve tumor
29:melanocytic nevus
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913:Ocular neoplasia
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506:(5): 319–327.
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279:(5): 1286–94.
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473:cite journal
443:(4): 325–9.
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220:(2): 110–2.
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92:radiotherapy
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82:
74:
57:
42:
33:neural crest
25:melanocytoma
24:
22:
918:Brain tumor
581:: 855–859.
60:optic nerve
907:Categories
720:(1): 245.
143:References
112:meningioma
108:schwannoma
835:1547-5654
792:0090-3019
736:2152-7806
657:0187-4519
597:1177-5483
556:(Review).
520:0039-6257
437:Pathologe
399:2039-7283
385:(3): 60.
339:0972-2327
236:1793-5482
184:0039-6257
39:Histology
884:17824163
843:11599841
800:12681556
754:30613434
695:17542513
615:20714362
554:12207136
465:41524594
417:24765321
357:21264144
254:22347335
192:16500211
126:See also
875:1899854
745:6293867
606:2921292
528:3992470
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408:3981369
348:3021939
295:4343293
245:3277064
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461:S2CID
880:PMID
839:PMID
831:ISSN
796:PMID
788:ISSN
750:PMID
732:ISSN
691:PMID
653:ISSN
611:PMID
593:ISSN
550:PMID
544:In:
524:PMID
516:ISSN
479:link
453:PMID
413:PMID
395:ISSN
353:PMID
335:ISSN
291:PMID
250:PMID
232:ISSN
188:PMID
180:ISSN
110:and
870:PMC
823:doi
780:doi
740:PMC
722:doi
683:doi
643:doi
601:PMC
583:doi
508:doi
445:doi
403:PMC
387:doi
343:PMC
325:doi
281:doi
240:PMC
222:doi
172:doi
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