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Masculinizing hormone therapy

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2607:(Delatestryl or Xyosted) which are almost interchangeable. Testosterone enanthate is purported to be slightly better with respect to even testosterone release, but this is probably more of a concern for bodybuilders who use the drugs at higher doses (250–1000 mg/week) than the replacement doses used by transgender men (50–100 mg/week). These testosterone esters are mixed with different oils, so some individuals may tolerate one better than the other. Testosterone enanthate costs more than testosterone cypionate and is more typically the one prescribed for 1798:
even after adjusting for age, diabetes mellitus, chronic kidney disease, smoking, hypertension, hypercholesterolemia, and exercise—though the study did not include data about whether the subjects were undergoing hormone therapy and did not control for stressors. The study found that transgender men have a >4-fold and 2-fold increased odds of having a myocardial infarction when compared with cisgender women and cisgender men, respectively. Though it is not always the case, testosterone for transmasculine people is often intended to be used long-term.
2648: 1655: 1606: 3925: 1361: 1385: 1373: 25: 2927:(DHT) (referred to as androstanolone or stanolone when used medically) can also be used in place of testosterone as an androgen. The availability of DHT is limited; it is not available in the United States or Canada, for instance, but it is available in certain European countries, including the United Kingdom, France, Spain, Belgium, Italy, and Luxembourg. DHT is available in formulations including 3939: 2616:(Nebido, Aveed) provides significantly improved testosterone delivery with far less variation outside the eugonadal range than other formulations with injections required only four times yearly. However, each quarterly dose requires an injection of 4 mL of oil which may require multiple simultaneous injections. Testosterone undecanoate is also much more expensive as it is still under 2931:, buccal or sublingual tablets, and as esters in oil for intramuscular injection. Relative to testosterone, and similarly to many synthetic AAS, DHT has the potential advantages of not being locally potentiated in so-called androgenic tissues that express 5α-reductase (as DHT is already 5α-reduced) and of not being aromatized into an estrogen (it is not a substrate for aromatase). 2760:/month). Testosterone is absorbed through the oral mucosa and avoids the first-pass metabolism in the liver which is the cause of many of the adverse effects of oral testosterone undecanoate. The lozenges can cause gum irritation, taste changes, and headache but most side effects diminish after two weeks. The lozenge is 'mucoadhesive' and must be applied twice daily. 5132:
In addition, oral finasteride may block the development of wanted secondary physical features, including voice change, body hair and composition, and clitoromegaly. Therefore, it is important to ensure that all desired changes are complete before the initiation of treatment with finasteride, which is
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Testosterone increases body weight (and increases appetite). The form that this weight gain will take depends on diet and exercise as well as genetic factors. Since testosterone has anabolic effects, gain of lean muscle mass will be easier than it previously was for transgender men. Moderate amounts
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It is unknown whether the risk of ovarian cancer is increased, decreased or unchanged in transgender men compared to women. It is unlikely to be determined in the near future because ovarian cancer is a relatively rare disease and the population of transgender men is too small to do the appropriate
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The adverse side effects of injected testosterone esters are generally associated with high peak levels in the first few days after an injection. Some side effects may be ameliorated by using a shorter dosing interval (weekly or every ten days instead of twice monthly with testosterone enanthate or
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Due to insufficient comprehensive research, there is no consensus on the full range of risks of lengthy testosterone administration, especially as it is difficult to achieve a sufficient number of participants for results to be meaningful.Two 2019 studies indicate the potential for elevated risk of
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Ovarian tissue banking – Ovarian tissue is frozen after oophorectomy. Even after long-term androgen therapy, ovaries usually retain usable follicles. Eventual use of frozen ovaries will require replantation into the transgender man for stimulation and harvest, but may eventually be
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Oocyte banking – hormonal stimulation to 'hyper-ovulate' with transvaginal oocyte harvest for freezing. Previously using the "slow-freezing" cryopreservation method there were very poor survival rates of banked oocytes. However, the advent of vitrification, a rapid freezing process,
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should cease within 5 months of testosterone therapy (often sooner). If bleeding continues past 5 months, transgender men are strongly encouraged to see a gynecologist. A retrospective chart review of 74 menstruating individuals treated with intramuscular injected testosterone found that 4 stopped
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Implants, as subcutaneous pellets, can be used to deliver testosterone (brand name Testopel). 6 to 12 pellets are inserted under the skin every three months. This must be done in a physician's office, but is a relatively minor procedure done under local anesthetic. Pellets cost about $ 60 each, so
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women, with 11 vs. 3 cardiovascular events per 100,000 person-years, though the risk was less than that of cisgender men. Researchers were not able to control for smoking status or stressors. The other study found elevated risk of heart attacks among self-identified transgender men—which persisted
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occurs, and frequently reaches its apex within 2–3 years of therapy. Sizes generally range from 3–8 cm with 4–5 cm being about average. This is genetically determined, but some physicians advocate topical clitoral testosterone as an adjunct to growth before metoidioplasty. However, this
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changes are harder to define, since HRT is usually the first physical action that takes place when transitioning. This fact alone has a significant psychological impact, which is hard to distinguish from hormonally induced changes. Most trans men report an increase of energy and an increased sex
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Acne: generally worse the first few years of testosterone therapy (mimicking a second puberty). Can be treated with standard acne therapy. Initial treatment is with increased cleansing (at least twice daily) with an anti-acne or oil reducing scrub. If this doesn't work, additional therapy may be
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of the liver also may result in testosterone levels too low to provide satisfactory masculinization and suppress menses. Because of the short terminal half-life of testosterone, oral testosterone undecanoate must be administered two to four times per day, preferably with food (which improves its
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men). However, a single small study of trans men after oophorectomy demonstrated that androgens alone may be insufficient to slow bone loss. It is likely the case that pre-oophorectomy, residual estrogen production is protective. However, after oophorectomy, some trans men may have insufficient
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In pre-clinical models, testosterone XHT has been shown to lead to adverse cardiovascular effects, but adding a low-dose estrogen to that hormone therapy completely mitigated those effects. (Goetz LG, et al. "Addition of Estradiol to Cross-sex Testosterone Therapy Reduces Atherosclerosis Plaque
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Embryo banking – oocyte harvest as above with immediate fertilization and banking of the embryo. The sperm donor must be chosen before oophorectomy. Allows the possibility for embryos to later be placed in a surrogate, as opposed to a transgender man having to carry the pregnancy
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Some transgender men report mood swings, increased anger, and increased aggressiveness after starting androgen therapy. Studies are limited and small scale, however, based on self reporting over a short period of time (7 months). In a study by Motta et al., trans men also reported better anger
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Injectable forms of testosterone can cause a lung problem called pulmonary oil microembolism (POME). Symptoms of POME include cough, shortness of breath, tightening of the throat, chest pain, sweating, dizziness, and fainting. A postmarketing analysis by the manufacturer of Aveed (testosterone
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is similarly unknown. A large multicenter study along with review of previous studies, noted no increased prevalence of endometrial hyperplasia or malignancy in transgender men undergoing hysterectomy. However while the endometrial linings in these studies were noted to be thin, they remained
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testosterone cypionate). 100 mg weekly gives a much lower peak level of testosterone than does 200 mg every two weeks, while still maintaining the same total dose of androgen. This benefit must be weighed against the discomfort and inconvenience of doubling the number of injections.
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Frequently the first sign of endometrial cancer is bleeding in post-menopausal women. Transgender men who have any bleeding after the cessation of menses with androgen therapy should be evaluated for age appropriate causes of abnormal uterine bleeding as per cisgender female guidelines.
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into estrogen, hence why the female ranges are referenced instead. In post-oophorectomy trans men, Israel and colleagues recommend that both testosterone and estrogen levels fall exactly within the normal male ranges. See the table below for all of the precise values they suggest.
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In women, increased levels of either estrogen or androgens are associated with decreased insulin sensitivity (which may predispose to diabetes). In a study of transgender males and females, decreased insulin sensitivity was found in both populations after four months of hormonal
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Some physicians advocate a Dexa (bone density) scan at the time of oophorectomy and every year or two thereafter to diagnose osteoporosis before it becomes severe enough to be symptomatic. This is important because the treatment of osteoporosis is most effective if done
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Cardiovascular risk factors are more than additive. (If high blood pressure is worth 10 and smoking is worth 10, together they are worth more than 20.) So for transgender men, the addition of risk with androgen therapy makes improving modifiable risk factors more
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Cheeks: Female cheeks tend to be fuller and more rounded. Under the influence of estrogen, fat is deposited beneath the skin and overall facial and body contours become softer. This is reversed by androgens, resulting in a male-type fat distribution after hormone
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Patches slowly diffuse testosterone through the skin and are replaced daily. The cost varies, as with all medication, from country to country, it is about $ 150/month in the US, and about €60 in Germany. Transdermal testosterone has the advantage of delivering a
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Androgen therapy effects are not all negative, however. Acutely it causes dilation of the coronary arteries, and in men with testosterone levels within the normal physiological range, higher levels are actually associated with a slight decrease in cardiovascular
2831:), although this can also be disadvantageous in certain aspects of masculinization like facial hair growth and normal body hair growth). Although many AAS are not potentiated in androgenic tissues, they have similar effects to testosterone in other tissues like 2723:
the cost is greater than injected testosterone when the cost of the physician visit and procedure are included. The primary advantages of Testopel are that it gives a much more constant blood level of testosterone yet requires attention only four times yearly.
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Hembree WC, Cohen-Kettenis PT, Gooren L, Hannema SE, Meyer WJ, Murad MH, Rosenthal SM, Safer JD, Tangpricha V, T'Sjoen GG (November 2017). "Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline".
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is another testosterone ester that is widely available, including in the US, Canada, and Europe, but it is very short-acting compared to the other testosterone esters and must be administered once every 2 or 3 days, and for this reason, is rarely used.
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Worse with injected testosterone (especially with longer intervals between doses) than with oral, transdermal, or Testopel. (Increase in RBCs occurs with the very high peaks from the injection. So decreasing dose and interval to 7–10 days instead of 14 may
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males in the US. Testosterone cypionate is more popular in the US than elsewhere (especially amongst bodybuilders). Other formulations exist but are more difficult to come by in the US. A formulation of injected testosterone available in Europe and the US,
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There is a risk of liver damage and liver cancer with all testosterone formulations, but this is minimal with all forms except oral or unless very high levels are administered. However, as with any drug that carries even a small risk of liver damage,
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when compared with the general female Dutch population. (As with all scientific studies, this does not conclusively prove that no causal link exists. A small to moderate detrimental effect remains a possibility, though a very large effect is more
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For the sake of clarification, the term "anabolic–androgenic steroid" is essentially synonymous with "androgen" (or with "anabolic steroid"), and that natural androgens like testosterone are also AAS. These drugs all share the same core
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has made oocyte cryopreservation a viable option for fertility preservation. It allows the possibility for eggs to later be fertilized and be placed in a surrogate, as opposed to a transgender man having to carry the pregnancy himself.
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after the first shot, 37 stopped within 6 months, 24 stopped after 6 months, and 9 required additional progesterone therapy. The time to menstrual cessation was individualized, with only a small correlation to testosterone dosage.
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In cisgender men, abnormally high or low levels of testosterone are both associated with insulin resistance (which eventually can result in Type II diabetes). So mid-normal levels of testosterone are the target for androgen
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Larynx: At puberty, the bones and cartilage of the voicebox tend to enlarge less in females than males. In most males, the larynx becomes visible as a bony "Adam's apple," which is developed in transgender men under hormone
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A study of 45 FtM individuals randomly assigned to receive testoviron depot (intramuscular, 100 mg/10 days), testosterone gel (50 mg/day), or testosterone undecanoate (intramuscular, 1000 mg) found increased
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can be used to suspend the advance of sex steroid induced, inappropriate pubertal changes for a period without inducing any changes in the gender-appropriate direction. GnRH analogues work by initially overstimulating the
2016: 1551:. Introducing exogenous (not internally produced) hormones into the body impacts it at every level and many patients report changes in energy levels, mood, appetite, etc. The goal of the therapy, and indeed all 3531:, this is not a noticeable effect in most trans men. HRT doses of testosterone are much lower than the typical doses taken by steroid-using athletes, and create testosterone levels comparable to those of most 2811:(ART) in cisgender men. However, they can be used in place of testosterone with similar effects, and can have certain advantages like less or no local potentiation in so-called androgenic tissues that express 3333:
Lips: Females, tend to have thicker, fleshier lips than males of the same size due to estrogen. Thus, after being administered androgens, transgender men may have a fat redistribution that results in smaller
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effects (due to differing capacities to be locally metabolized and potentiated by 5α-reductase), capacity for aromatization (i.e., conversion into an estrogen), and potential for liver damage may all differ.
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of young children after exposure to topical androgen preparations (both prescription and 'supplement' products) used by their caregivers demonstrates this very real risk, the same principle also applies to
2599:' drug formulations are created by mixing a substance with the drug that slows its release and prolongs the action of the drug. The two primarily used forms in the United States are the testosterone esters 3482:
possible in a lab as techniques for tissue culture improve. This option does not usually allow for placement into a surrogate as it may require the use of immunosuppressants on the part of the surrogate.
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More conventional therapies, including intramuscular injections, subcutaneous injections, and transdermal gels, have been extensively studied and show promising efficacy and outcomes with limited safety
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Grimstad FW, Fowler KG, New EP, Ferrando CA, Pollard RR, Chapman G, et al. (March 2019). "Uterine pathology in transmasculine persons on testosterone: a retrospective multicenter case series".
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are available. Both approximate normal physiological levels of testosterone better than the higher peaks associated with injection. Both can cause local skin irritation (more so with the patches).
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Pelusi C, Costantino A, Martelli V, Lambertini M, Bazzocchi A, Ponti F, et al. (December 2014). "Effects of three different testosterone formulations in female-to-male transsexual persons".
3463:, he may regain fertility on cessation of testosterone. With the ovarian changes of long-term androgen therapy, however, it may require months of cessation of testosterone and possibly assistive 3417:
Some transgender men report a decrease in breast size with androgen therapy. However, no morphological changes were found when this was studied and likely it is due to loss of fat in the breasts.
3362:(PCOS) morphology, as both PCOS and transgender men there is an up-regulation of testosterone receptors in the ovaries. Untreated PCOS is associated with a possibly increased risk of endometrial 3312:
Facial changes develop gradually over time, and sexual dimorphism (physical difference between the sexes) tends to increase with age. Within a population of similar body size and ethnicity:
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Because of these interactions, it is advised that trans men make their healthcare providers aware of their hormone therapy when this is relevant to their treatment for other medical issues.
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van Kesteren P, Lips P, Gooren LJ, Asscheman H, Megens J (March 1998). "Long-term follow-up of bone mineral density and bone metabolism in transsexuals treated with cross-sex hormones".
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In cisgender men, testosterone levels that are either significantly above or below normal are associated with increase cardiovascular risk. This may be causative or simply a correlation.
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If severe odor is a problem, an antibacterial soap like chlorhexidine may be used in the armpits when showering. After 1–2 weeks of daily use, a noticeable decrease in odor should occur.
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These medical uses of masculinizing hormone therapy are subject to individual health considerations and are typically administered under the supervision of healthcare professionals.
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Transdermal testosterone poses a risk of inadvertent exposure to others who come in contact with the patient's skin. This is most important for patients whose intimate partners are
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In certain cases, hormonal interventions are employed to delay puberty, offering individuals more time to explore their gender identity before undergoing permanent physical changes.
3720:. Estrogen supplementation is theoretically not usually necessary, as some of the injected testosterone will be aromatized into estrogen sufficient to maintain bone (as it does in 5056:"Topical dihydrotestosterone to treat micropenis secondary to partial androgen insensitivity syndrome (PAIS) before, during, and after puberty - A case series | Request PDF" 5194: 2756:
approved a buccal form of testosterone (Striant). Sublingual testosterone can also be made by some compounding pharmacies. Cost for Striant is greater than other formulations (
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Motta G, Crespi C, Mineccia V, Brustio PR, Manieri C, Lanfranco F (January 2018). "Does Testosterone Treatment Increase Anger Expression in a Population of Transgender Men?".
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Mwamba RN, Ekwonu A, Guimaraes P, Raheem OA (Nov 2022). "The efficacy, safety, and outcomes of testosterone use among transgender men patients: A review of the literature".
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range. Before oophorectomy, it is difficult and frequently impractical to fully suppress estrogen levels into the normal male range, especially with exogenous testosterone
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Administered as part of gender transition to align the physical appearance with the affirmed gender, inducing changes such as facial hair growth and deepening of the voice.
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Daily calcium supplementation and possibly Vitamin D3 and K2 are probably a good idea for most transgender men, but it is even more important after removal of the ovaries.
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Nose: The tips of the nasal bones tend to grow more in males than females, creating a larger (longer or wider) nose. Thus, androgens result in the development of the nose.
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to DHT. There are two forms of this enzyme: type 1 and 2. However, type 2 is the form that is most important to the development of male pattern hair loss. Males with
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Symptoms of OSA are noisy sleeping (snoring), excessive daytime sleepiness, morning headache, personality changes, and problems with judgment, memory, and attention.
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Meriggiola MC, Gava G (November 2015). "Endocrine care of transpeople part I. A review of cross-sex hormonal treatments, outcomes and adverse effects in transmen".
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Supra-physiological levels of androgens (generally due to abuse) are associated with significantly increased risks of strokes and heart attacks (even in the young).
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Testosterone may cause an increase in cortical bone thickness in transgender men (however this does not necessarily translate to a greater mechanical stability).
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trans men, therapeutic testosterone levels should optimally fall within the normal male range, whereas estrogen levels should optimally fall within the normal
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Pre-clinical research has suggested the importance of low-dose estrogen supplementation for those beginning cross-sex hormone therapy (XHT) during adolescence.
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or those who are parents of young children as both of these groups are more vulnerable to the masculinizing effects of androgens. Case reports of significant
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Sleep deprivation worsens almost all seizure disorders, so concurrent obstructive sleep apnea caused or worsened by androgen therapy may also be responsible.
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within 2–5 years of starting androgen therapy due to the possible increased risk. (Note: Testosterone dose can frequently be decreased after oophorectomy.)
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Bone is not static. It is constantly being reabsorbed and created. Osteoporosis results when bone formation occurs at a rate less than bone resorption.
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Oral testosterone is provided exclusively as testosterone undecanoate. It is available in Europe and Canada, but not in the US. Once absorbed from the
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A transgender man's hematocrit (the percentage of whole blood made up of red blood cells) should be judged against normal age-adjusted values for men.
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people also receive this form of therapy, either starting in childhood to confirm the assigned sex or later if the assignment proves to be incorrect.
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in transgender men taking testosterone. However, they may also slow or reduce certain aspects of masculinization, such as facial hair growth, normal
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Anderson, William J.; Kolin, David L.; Neville, Grace; Diamond, David A.; Crum, Christopher P.; Hirsch, Michelle S.; Vargas, Sara O. (August 2020).
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or low testosterone levels in assigned female at birth (AFAB) individuals, fostering the development of masculine secondary sexual characteristics.
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hormones in the form of testosterone (including esters) and do not apply to those taking synthetic AAS (e.g., nandrolone) or dihydrotestosterone.
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Untreated OSA may have significant adverse effects on the heart, blood pressure, mood, and may cause headaches and worsen seizure disorders.
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Most transgender men report a significantly increased libido. Some report that this decreases somewhat after several years on testosterone.
2891:(via which they act as long-lasting depots similarly to testosterone esters) but have no more risk of liver damage than does testosterone. 1793:
cardiovascular events. One study found that transgender men taking testosterone had an increased risk of cardiovascular events compared to
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Hembree WC, Cohen-Kettenis P, Delemarre-van de Waal HA, Gooren LJ, Meyer WJ, Spack NP, et al. (Endocrine Society) (September 2009).
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A single retrospective study in the medical literature of 293 trans men treated with testosterone (range of 2 months to 41 years) by the
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As the age at which transgender people begin therapy decreases, retention of reproductive potential may become more important to some.
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control. Many transgender men, however, report improved mood, decreased emotional lability, and a lessening of anger and aggression.
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of testosterone in the blood is about 70 minutes, so it is necessary to have a continuous supply of the hormone for masculinization.
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Polderman KH, Gooren LJ, Asscheman H, Bakker A, Heine RJ (July 1994). "Induction of insulin resistance by androgens and estrogens".
5582:"Early Access to Testosterone Therapy in Transgender and Gender-Diverse Adults Seeking Masculinization: A Randomized Clinical Trial" 3675:
Many transgender men report an increased energy level, decreased need for sleep, and increased alertness after testosterone therapy.
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can be significantly worsened with androgen therapy. Headaches can also become problematic in men without prior headache disorders.
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Xu, Rena; Diamond, David A.; Borer, Joseph G.; Estrada, Carlos; Yu, Richard; Anderson, William J.; Vargas, Sara O. (2022-03-01).
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HeresovĂĄ J, PobisovĂĄ Z, Hampl R, StĂĄrka L (December 1986). "Androgen administration to transsexual women. II. Hormonal changes".
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Recent studies have found that cross-hormone therapy in trans men results in an increase in brain volume up to male proportions.
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then rapidly desensitizing it to the effects of GnRH. Over a period of weeks, gonadal androgen production is greatly reduced.
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to a greatly reduced extent relative to testosterone or not at all, and for this reason, are associated with reduced or no
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Jaw: The jaw in males tends to grow wider and more deeply sculptured than in females, thus the jaw widens under androgens.
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can be administered, potentially in conjunction with an aromatase inhibitor or a GnRH analogue, to increase final height.
57: 9144: 9048: 7162: 6372: 5850: 5639:"Addition of Estradiol to Cross-Sex Testosterone Therapy Reduces Atherosclerosis Plaque Formation in Female ApoE-/- Mice" 697: 3504:: some seizure disorders are androgen-dependent. These may be worsened or (very rarely) unmasked with androgen therapy. 3470:
If a transgender man is planning on having a hysterectomy/oophorectomy, future reproduction may still be preserved by:
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are greatly reduced or eliminated. This may be useful for transgender men prior to initiation of testosterone therapy.
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2. The sex steroids do have important other functions. The high cost of GnRH analogues is often a significant factor.
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in a group of transgender and gender expansive adults found that the group given treatment had significantly reduced
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men. These levels of testosterone have not been proven to cause more aggression than comparable levels of estrogen.
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The purpose of this form of therapy is to cause the development of the secondary sex characteristics of the desired
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treatments, is to provide patients with a more satisfying body that is more congruent with their gender identity.
8779: 8597: 6392: 6137: 3131:(DMPA) may be injected every three months just as it is used for contraception. Generally after the first cycle, 2640:(blood levels drawn just before your next shot). A trough level of 500 ng/dL is sought. (Normal range for a 2580:. No differences were found between the different formulations of testosterone, and at week 54 all subjects were 1803:
The efficacy, safety, and outcomes of testosterone use among transgender men patients: A review of the literature
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Krempasky C, Harris M, Abern L, Grimstad F (February 2020). "Contraception across the transmasculine spectrum".
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With androgen therapy, genetics primarily determines how much hair will develop (and where) as well as whether
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Risk is higher in transgender men who are obese, smoke, or have COPD (Chronic Obstructive Pulmonary Disease).
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should be counseled on utilizing concomitant contraception. All contraceptive methods are acceptable for use.
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One of the earliest widely distributed guides to transmasculine transition, written by transgender activist
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Enzyme inducers – May cause decreased levels of testosterone (and other sex steroid) levels:
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undeconate injection) found that POME occurred at a rate of less than 1% per injection per year for Aveed.
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Increases the effect of some oral medicines for diabetes and can cause dangerously low blood sugar levels.
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which diffuses into the circulation, peaking at 4 hours and decreasing slowly over the rest of the day.
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Brow: Males tend to develop heavier bony brows than females, thus HRT results in a more prominent brow.
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Testosterone (frequently in large doses) was previously used to treat anemia from bone marrow failure.
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of exercise will cause greater gains and will ameliorate some of the adverse effects of testosterone.
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Fabris B, Bernardi S, Trombetta C (March 2015). "Cross-sex hormone therapy for gender dysphoria".
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Androgen therapy can adversely affect the blood lipid profile by causing decreases in HDL (good)
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Transdermal testosterone is available throughout the world under the brand names Andromen Forte,
2621: 2573: 1755: 387: 197: 35: 4949: 4144:"Occurrence of Acute Cardiovascular Events in Transgender Individuals Receiving Hormone Therapy" 9223: 8490: 8350: 8280: 7611: 7388: 7341: 6427: 6333: 6239: 6235: 6176: 6078: 6012: 6007: 6002: 5992: 5029: 3796: 2900: 2732: 2651: 2604: 2600: 2198: 2171: 1971: 795: 692: 396: 5580:
Nolan, Brendan J.; Zwickl, Sav; Locke, Peter; Zajac, Jeffrey D.; Cheung, Ada S. (2023-09-07).
5504:
Pol HE, Cohen-Kettenis PT, Van Haren NE, Peper JS, Brans RG, Cahn W, et al. (July 2006).
4930: 4906: 4095:"Endocrine treatment of transsexual persons: an Endocrine Society clinical practice guideline" 3977: 3795:
Severe polycythemia predisposes to both venous and arterial thrombosis (blood clots) such as:
3300: 9253: 9215: 8673: 8360: 8290: 8223: 8028: 7412: 7406: 7336: 7306: 7216: 7204: 7051: 6712: 5997: 5892: 5857:
Medical Therapy and Health Maintenance for Transgender Men: A Guide For Health Care Providers
5814: 5764:
Goetz TG, Mamillapalli R, Devlin MJ, Robbins AE, Majidi-Zolbin M, Taylor HS (November 2017).
5637:
Goetz TG, Mamillapalli R, Sahin C, Majidi-Zolbin M, Ge G, Mani A, Taylor HS (February 2018).
5233:
Medical therapy and health maintenance for transgender men: A guide for health care providers
5002: 4487:
Fishman SL, Paliou M, Poretsky L, Hembree WC (2019). "Endocrine Care of Transgender Adults".
4294: 4185:"Cardiovascular Disease Risk Factors and Myocardial Infarction in the Transgender Population" 3804: 3285: 2856: 2852: 2740: 1501: 1319: 714: 504: 5875: 4606:
Arif T, Dorjay K, Adil M, Sami M (2017). "Dutasteride in Androgenetic Alopecia: An Update".
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Both estrogens and androgens are necessary for both cisgender males and females for healthy
2950:). As the masculinizing effects of testosterone is limited in AIS, DHT more easily binds to 9265: 8530: 8392: 8345: 8315: 8036: 7533: 7481: 7417: 7393: 7366: 7331: 7316: 7063: 6871: 6762: 6357: 6342: 6318: 6211: 6196: 3658: 3547: 3109: 2792: 2636:
Injected testosterone esters should be started at a low dose and titrated upwards based on
2557: 2290: 1955: 1389: 687: 637: 627: 204: 5258:"The Response of the Menstrual Cycle to Initiation of Hormonal Therapy in Transgender Men" 2887:, whereas AAS that are not 17α-alkylated, like nandrolone esters, must be administered by 2807:(AR) similarly to testosterone but are not usually used in HRT for transgender men or for 8: 9257: 9181: 9101: 9005: 8681: 8475: 8407: 8397: 8305: 8300: 8088: 8032: 7956: 7850: 7682: 7362: 7358: 7291: 7096: 7055: 6959: 6905: 6887: 6747: 6722: 6717: 6699: 6688: 6642: 6362: 5070:"Partial Androgen Insensitivity Syndrome (PAIS) | Intersex Society of North America" 4183:
Alzahrani T, Nguyen T, Ryan A, Dwairy A, McCaffrey J, Yunus R, et al. (April 2019).
3278: 3064:(which occurs during adolescence and is mediated by estrogen), antiestrogens can prevent 3037: 2987: 2924: 2896: 2880: 2676: 1901: 1596: 1299: 1198: 936: 707: 167: 5614: 3706:
Both estrogen and testosterone help stimulate bone formation (T, especially at puberty).
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study. However, it has been recommended by some physicians that transgender men have an
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Therapy is via phlebotomy (periodic therapeutic blood draws similar to blood donation).
3421: 3378: 3061: 3053: 2868: 2773: 1805:, while pointing out that more research is needed for newer therapies, concludes that: 1524:
and other treatments to reverse. The medications used for FTM therapy include, mainly,
1365: 1339: 220: 5816:
Transgender Care: Recommended Guidelines, Practical Information, and Personal Accounts
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Testosterone is converted (within the cells of the hair follicle's dermal papilla) by
9273: 8355: 8340: 8048: 7861: 7711: 7402: 7350: 7225: 7071: 6895: 6752: 6742: 6680: 6186: 6152: 5820: 5795: 5738: 5734: 5703: 5668: 5619: 5601: 5581: 5562: 5527: 5490: 5478: 5447: 5435: 5427: 5392: 5380: 5372: 5325: 5287: 5236: 5180: 5168: 5123: 5055: 5035: 5008: 4984: 4888: 4830: 4734: 4699: 4623: 4588: 4553: 4510: 4500: 4473: 4461: 4418: 4387: 4375: 4332: 4257: 4206: 4165: 4116: 4037: 3555: 3097: 2951: 2828: 2804: 2664: 2617: 1881: 905: 899: 360: 225: 191: 8165: 5750: 5337: 4522: 4430: 4201: 4184: 4142:
Nota NM, Wiepjes CM, de Blok CJ, Gooren LJ, Kreukels BP, den Heijer M (March 2019).
4128: 3060:) in transgender men. In addition, in those who have not yet undergone or completed 9231: 9164: 9156: 9134: 8848: 8613: 8605: 8379: 7923: 7911: 7523: 7439: 7252: 7013: 6944: 6267: 5954: 5785: 5777: 5730: 5695: 5658: 5650: 5609: 5593: 5554: 5517: 5470: 5419: 5364: 5317: 5277: 5269: 5158: 5113: 5105: 4974: 4964: 4878: 4868: 4726: 4689: 4679: 4615: 4580: 4545: 4492: 4453: 4410: 4367: 4344: 4324: 4280: 4247: 4237: 4196: 4155: 4106: 4027: 4017: 3551: 3253:
Change in body odor – less sweet and musky, more metallic and acrid.
2904: 2780: 2668: 2647: 2577: 1947: 1742: 1690: 1544: 1509: 757: 403: 4931:"Overview of masculinizing hormone therapy | Gender Affirming Health Program" 3428:(painful vaginal intercourse). This can be alleviated with topical estrogen cream. 9227: 9038: 8636: 8621: 8275: 8200: 8007: 7943: 7631: 7584: 7461: 7037: 6602: 6512: 6397: 5872:: A comprehensive guide to gender transition for persons assigned female at birth 5863: 5368: 3944: 3639: 3389:
tissue has been documented in transmasculine individuals on testosterone therapy.
3052:) can be used to reduce the effects of high levels of endogenous estrogen (e.g., 3011: 2736: 2596: 2587:
1 year after treatment, general life satisfaction was increased in all subjects.
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distribution. It cannot undo many of the changes produced by naturally occurring
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to become pregnant. Testosterone must be withheld for the duration of pregnancy.
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Some physicians see acne as a contraindication to increasing testosterone dose.
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Enzyme inhibitors – May cause increased levels of testosterone:
1762: 1482: 1309: 877: 872: 419: 7173: 6089: 5699: 4668:"Hormonal Treatment Strategies Tailored to Non-Binary Transgender Individuals" 4457: 4371: 4226:"Hormonal Treatment Strategies Tailored to Non-Binary Transgender Individuals" 9378: 8617: 8460: 7567: 6502: 5605: 5531: 5431: 5407: 5376: 4907:"Overview of masculinizing hormone therapy | Gender Affirming Health Program" 4778: 4514: 3978:"Overview of masculinizing hormone therapy | Gender Affirming Health Program" 3776:
Increased red blood cell mass usually from overproduction by the bone marrow.
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The optimal ranges listed for testosterone only apply to individuals taking
2823:(which results in a reduced rate of skin and hair-related side effects like 259: 9111: 9074: 9068: 9064: 9056: 8978: 8811: 8694: 8689: 8658: 8587: 8572: 8547: 8505: 8500: 8424: 8419: 8372: 8365: 8247: 7990: 7927: 7866: 7795: 7790: 7785: 7780: 7760: 7755: 7702: 7669: 7649: 7643: 7639: 7498: 7493: 7287: 7268: 7208: 7027: 6915: 6822: 6807: 6797: 6792: 6782: 6737: 6732: 6671: 6638: 6624: 6610: 6522: 6487: 6452: 6442: 6407: 6352: 6303: 6298: 6124: 5929: 5915: 5879: 5799: 5672: 5623: 5566: 5482: 5439: 5384: 5329: 5291: 5273: 5172: 5127: 4988: 4892: 4752: 4738: 4703: 4627: 4584: 4557: 4465: 4422: 4379: 4336: 4261: 4210: 4169: 4120: 4041: 3831: 3770: 3717: 3713: 3703:
Estrogen is the predominant sex hormone that slows bone loss (even in men).
3527:
While a high level of testosterone is often associated with an increase in
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testosterone is absorbed and should be calculated into one's total regimen.
3344: 3226: 3125: 3121: 3069: 3065: 3033: 3022: 2979: 2963: 2928: 2860: 2706: 2608: 1975: 1967: 1889: 1873: 1738: 1724: 1568: 1377: 893: 556: 498: 366: 249: 6373:
Trenbolone hexahydrobenzylcarbonate (trenbolone cyclohexylmethylcarbonate)
5742: 5707: 5654: 4969: 4805: 4659: 4592: 4328: 334: 9294: 9245: 9201: 9197: 9189: 9174: 9168: 9105: 9095: 8903: 8888: 8868: 8542: 8480: 8465: 8447: 8414: 8402: 8262: 8024: 7997: 7976: 7972: 7964: 7949: 7939: 7891: 7830: 7825: 7775: 7663: 7606: 7432: 7382: 7301: 7242: 7047: 7031: 6979: 6975: 6967: 6952: 6925: 6866: 6861: 6856: 6851: 6817: 6777: 6632: 6572: 6556: 6482: 6477: 6447: 6412: 6402: 6387: 6382: 6308: 6255: 5147:"Is there a role for 5α-reductase inhibitors in transgender individuals?" 4950:"Prenatal Virilization Associated with Paternal Testosterone Gel Therapy" 4111: 4094: 3827:
should be consistently done to assess hormone levels and liver function.
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of acting as agonists of the AR and have similar effects, although their
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Information for the Female to Male Crossdresser and Transsexual (1985):
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While testosterone decreases ovulation, it is not an approved form of
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Defreyne J, T'Sjoen G (June 2019). "Transmasculine Hormone Therapy".
4285: 3999: 3997: 3924: 3839: 3721: 3591: 3581: 3532: 3439: 3407: 3101: 3049: 2973: 2967: 2848: 2824: 2680: 2641: 1983: 1897: 1850: 1794: 1698: 1505: 1466: 1360: 1149: 867: 324: 279: 244: 210: 5853:- masculinizing and feminizing clinical protocols aimed at providers 3420:
Androgen therapy (and suppression of estrogen production) may cause
24: 9152: 8949: 8924: 8535: 8083: 8018: 7919: 7750: 7295: 7248: 7091: 6993: 6582: 6259: 6132: 6120: 5949: 5636: 4783: 4536:
Irwig MS (April 2017). "Testosterone therapy for transgender men".
3501: 3495: 3386: 3220: 3213: 3143:
In those who have not yet started or completed epiphyseal closure,
2935: 2912: 2908: 2776: 2711: 2702: 2332: 2298: 2061: 1963: 1943: 1913: 1854: 1714: 1709: 1552: 1525: 1490: 1458: 1314: 340: 317: 8646: 7732: 5408:"Prostatic metaplasia of the vagina in transmasculine individuals" 4716: 4313: 3994: 3438:; transgender men who engage in sex which places them at risk for 9284: 8437: 8231: 8068: 7621: 6542: 6160: 4666:
Cocchetti C, Ristori J, Romani A, Maggi M, Fisher AD (May 2020).
4224:
Cocchetti C, Ristori J, Romani A, Maggi M, Fisher AD (May 2020).
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Medications used in hormone therapy for transgender men include
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The main effects of testosterone in trans men are as follows:
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of hormones over a given period and having a simple method of
1539:
While the therapy cannot undo the effects of a person's first
5199: 3587: 3018: 2788: 1838: 1831: 1749: 254: 5869: 5770:
American Journal of Physiology. Endocrinology and Metabolism
5460: 4806:"Testosterone Injections: Uses, Side Effects & Warnings" 4486: 8281:
Algestone acetophenide (dihydroxyprogesterone acetophenide)
5350: 4665: 4570: 4274: 4223: 3694: 3620:
sensitivity (perhaps worsening a predisposition to develop
3274: 3072:(estrogen limits height by causing the epiphyses to fuse). 2832: 2816: 2691: 1780: 1324: 295: 8270:
17α-Hydroxyprogesterone (and closely related) derivatives:
5544: 3638:
The most important modifiable risk factor for many men is
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Gianna Israel and colleagues have suggested that for pre-
3823:
During HRT, especially in the early stages of treatment,
2840: 2753: 1497: 1329: 4779:"FDA Approves Aveed Testosterone Jab, with Restrictions" 4141: 3646:
Formation in Female ApoE -/- Mice." Endocrinology. 2017)
3609:
Androgen therapy redistributes the fat toward abdominal
2158: 1908:
Testosterone can also alter the effects of other drugs:
1547:, and can help the person to "pass" or be seen as their 4753:"Aveed (testosterone undecanoate) FDA Approval History" 4357: 3602:, increases in LDL (bad) cholesterol, and increases in 3586:
from 1975 to 1994 showed no increase in cardiovascular
2954:
and cannot be directly converted into estrogen via the
9346: 9145: 9119: 9112: 9049: 8820: 8803: 8008: 7991: 7657: 7650: 4831:"Testosterone Injection: MedlinePlus Drug Information" 3358:
After long-term androgen therapy, ovaries may develop
3338: 2966:. DHT can be converted into testosterone which can be 8195: 5579: 5405: 4446:
Endocrinology and Metabolism Clinics of North America
3616:
Androgen therapy can cause weight gain and decreased
3277:
follicles is mainly due to the more potent androgen,
2654:, a medication used in masculinizing hormone therapy. 7674: 7595:
Methestrol dipropionate (promethestrol dipropionate)
6652: 6279:
Androstanolone (stanolone, dihydrotestosterone, DHT)
5688:
The Journal of Clinical Endocrinology and Metabolism
5007:. Taylor & Francis. January 2000. pp. 63–. 4317:
The Journal of Clinical Endocrinology and Metabolism
4099:
The Journal of Clinical Endocrinology and Metabolism
3920: 3751:
OSA may be worsened or unmasked by androgen therapy.
3414:). Use of testosterone is no exception to this rule. 2994:(FSH) which in turn cause the gonads to produce sex 1927:
used in the management of cardiovascular conditions;
9143:Sex steroid agonists (via negative feedback on the 6518:
Normethandrone (methylestrenolone, normethisterone)
6294:
Drostanolone propionate (dromostanolone propionate)
6138: 5812: 4443: 4437: 3661:(or at least ALT) should be periodically monitored. 3182:
Acne (especially in the first few years of therapy)
2473:The natural production of testosterone by the male 49:. Unsourced material may be challenged and removed. 9047:Sex steroid antagonists (via disinhibition of the 8651:Tooltip Selective progesterone receptor modulators 7737:Tooltip selective estrogen receptor downregulators 5813:Israel GE, Tarver DE, Shaffer JS (26 April 2001). 5021: 4605: 4394: 4351: 3716:must continue androgen therapy to avoid premature 2974:Gonadotropin-releasing hormone modulator analogues 5034:. Jones & Bartlett Learning. pp. 1100–. 4480: 4299:: CS1 maint: DOI inactive as of September 2024 ( 3788:Tendency to become polycythemic worsens with age. 1635: 9376: 6408:Metandienone (methandienone, methandrostenolone) 5806: 5230: 5004:Index Nominum 2000: International Drug Directory 4995: 4957:International Journal of Pediatric Endocrinology 4854: 4491:. Contemporary Endocrinology. pp. 143–163. 4189:Circulation: Cardiovascular Quality and Outcomes 3524:drive. Many also report feeling more confident. 3235:– possible shrinking and/or softening of breasts 2031:Medications and dosages used in transgender men 1646:Transgender hormone therapy § Accessibility 264: 7561:Mestilbol (diethylstilbestrol monomethyl ether) 7203: 6119: 5087: 5085: 5083: 2182: 1697:exist. An absolute medical contraindication is 1642:Transgender hormone therapy § Requirements 9282:Others (mixed or unknown mechanism of action): 9084:Tooltip Selective estrogen receptor modulators 7728:Tooltip selective estrogen receptor modulators 6460:17α-Alkylated dihydrotestosterone derivatives: 5226: 5224: 5222: 5094:"Dermatologic care of the transgender patient" 5027: 4599: 4400: 2847:. Also, many AAS, like nandrolone esters, are 1982:to suppress estrogen and progesterone levels; 1767:Bleeding disorders (for injected testosterone) 8787: 8674: 8224: 8181: 7551:Dimestrol (diethylstilbestrol dimethyl ether) 7189: 6500:17α-Alkylated 19-nortestosterone derivatives: 6105: 5900: 5463:American Journal of Obstetrics and Gynecology 5310:American Journal of Obstetrics and Gynecology 5133:frequently after 2 years of testosterone use. 4634: 4056:"Masculinizing hormone therapy - Mayo Clinic" 2986:(GnRH) to stimulate the pituitary to produce 2938:men to initiate the development of masculine 2017: 1407: 8408:Segesterone acetate (nestorone, elcometrine) 6319:Metenolone enanthate (methenolone enanthate) 5255: 5098:International Journal of Women's Dermatology 5080: 4947: 2584:(no longer experiencing menstrual periods). 8986: 7683: 7556:Fosfestrol (diethylstilbestrol diphosphate) 6643: 5955:Androgen/anabolic steroid (as a medication) 5497: 5219: 4564: 3650: 3250:Increased activity of oil and sweat glands. 1777:effects on most but not all breast cancers) 1773:History of breast cancer (testosterone has 1580:Puberty suppression in gender diverse youth 8794: 8780: 8393:Gestonorone caproate (gestronol hexanoate) 8188: 8174: 7196: 7182: 6112: 6098: 5907: 5893: 5357:The American Journal of Surgical Pathology 5031:Conservative Management of Sports Injuries 4855:Pastuszak AW, Hu Y, Freid JD (June 2020). 4006:"Hormone therapy for transgender patients" 3739: 3080: 2024: 2010: 1414: 1400: 16:Type of gender-affirming medical treatment 8311:Flugestone acetate (flurogestone acetate) 7712: 7477:Prasterone (dehydroepiandrosterone; DHEA) 7226: 6681: 6363:Oxabolone cipionate (oxabolone cypionate) 6207:Prasterone (dehydroepiandrosterone, DHEA) 6153: 6074:Dehydroepiandrosterone (DHEA; prasterone) 6059:Dihydrotestosterone (DHT; androstanolone) 5789: 5662: 5613: 5521: 5281: 5187: 5162: 5138: 5117: 4978: 4968: 4882: 4872: 4693: 4683: 4529: 4360:Journal of Endocrinological Investigation 4284: 4251: 4241: 4200: 4159: 4110: 4031: 4021: 3570: 3565: 3297:congenital 5α-reductase type 2 deficiency 2513: 2511: 2501: 2499: 2497: 2495: 2493: 2491: 2489: 2487: 2485: 2483: 2069:40–80 mg up to three times/day 109:Learn how and when to remove this message 7433:Estropipate (piperazine estrone sulfate) 6314:Metenolone acetate (methenolone acetate) 5091: 4538:The Lancet. Diabetes & Endocrinology 3514: 3176:Increased sweat and changes in body odor 3036:(or so-called "estrogen blockers") like 2763: 2747: 2646: 1704:Relative medical contraindications are: 6380:17α-Alkylated testosterone derivatives: 5851:Tom Waddell Clinic Transgender Protocol 5819:. Temple University Press. p. 69. 5235:. Lyon-Martin Women's Health Services. 4573:Experimental and Clinical Endocrinology 3903:225–900 ng/dL (post-oophorectomy) 3488: 3455:If a transgender man has not undergone 3446: 3303:) never develop male-pattern hair loss. 3170:Cessation of ovulation and menstruation 2944:partial androgen insensitivity syndrome 2529: 2527: 2505:Also available under other brand names. 1912:Increases the blood thinning effect of 1770:Significant history of violent behavior 9377: 9124:Tooltip gonadotropin-releasing hormone 8808:Tooltip Gonadotropin-releasing hormone 8276:Acetomepregenol (mepregenol diacetate) 6393:Chlorodehydromethyltestosterone (CDMT) 4776: 3046:selective estrogen receptor modulators 2919: 2768: 2508: 2480: 1564:Testosterone replacement therapy (TRT) 1477:), and is predominantly used to treat 8775: 8169: 7177: 6533:Norvinisterone (vinylnortestosterone) 6212:Prasterone enanthate (DHEA enanthate) 6093: 5888: 5231:Gorton RN, Jamie Buth MD (May 2005). 5144: 4535: 4003: 3901:225–900 ng/dL (pre-oophorectomy) 2352: 2073: 1574:Gender affirmation in transgender men 9349:and gonadotropin receptor modulators 7679:Tooltip follicle-stimulating hormone 6657:Tooltip human chorionic gonadotropin 6540:17α-Ethynyltestosterone derivatives: 3898:25–95 ng/dL (post-orchiectomy) 3665: 3179:Prominence of veins and coarser skin 3120:Progestogens can be used to control 2942:, particularly for individuals with 2524: 2477:is between 3 and 11 mg per day. 2428: 1888:(an anti-ulcer agent that can cause 1684: 1649: 1600: 47:adding citations to reliable sources 18: 7163:List of androgens/anabolic steroids 6143:Tooltip anabolic–androgenic steroid 5256:Ahmad S, Leinung M (October 2017). 4010:Translational Andrology and Urology 3896:95–225 ng/dL (pre-orchiectomy) 3339:Endocrine and gynecological changes 3239: 2970:into estrogen however this is low. 2113: 449:Puberty-suppressing hormone therapy 13: 8516:Normethandrone (methylestrenolone) 8084:Androvax (androstenedione albumin) 7092:Androvax (androstenedione albumin) 6530:17α-Vinyltestosterone derivatives: 6413:Methandriol (methylandrostenediol) 5598:10.1001/jamanetworkopen.2023.31919 3882:< 40 pg/mL (post-oophorectomy) 3229:if given before the end of puberty 2348:150mg/day or 200mg twice/day 1758:or risk factors for this condition 14: 9396: 9364:Progestogens and antiprogestogens 8964:+estradiol/norethisterone acetate 8150:Progestogens and antiprogestogens 7158:Progestogens and antiprogestogens 6557:ethisterone (ethynyltestosterone) 6217:Prasterone sulfate (DHEA sulfate) 5844: 5510:European Journal of Endocrinology 4620:10.2174/1574884712666170310111125 4161:10.1161/CIRCULATIONAHA.118.038584 3880:< 400 pg/mL (pre-oophorectomy) 3818: 3424:and dryness, which may result in 3307: 3138: 8746:Progesterone receptor modulators 7546:Diethylstilbestrol esters/ethers 7541:Diethylstilbestrol (stilbestrol) 6438:Methyltestosterone 3-hexyl ether 6418:Methandriol bisenanthoyl acetate 6276:Dihydrotestosterone derivatives: 5945:Pharmacokinetics of testosterone 5940:Pharmacodynamics of testosterone 5914: 5735:10.1046/j.1365-2265.1998.00396.x 3937: 3923: 3877:40–400 pg/mL (post-orchiectomy) 3028: 2644:man is 290 to 900 ng/dL). 2568:, decreased fat mass, decreased 1892:in men because of this effect). 1653: 1604: 1451:secondary sexual characteristics 1441:) hormone therapy, is a form of 1384: 1383: 1371: 1359: 510:Assisted reproductive technology 23: 8455:19-Nortestosterone derivatives: 8387:19-Norprogesterone derivatives: 6331:19-Nortestosterone derivatives: 6069:Nandrolone (19-nortestosterone) 5757: 5714: 5679: 5630: 5573: 5538: 5454: 5399: 5344: 5249: 5062: 5048: 5028:Hyde TE, Gengenbach MS (2007). 4941: 4923: 4899: 4848: 4823: 4798: 4770: 4745: 4710: 4642:"Orilissa (elagolix) FDA Label" 4202:10.1161/CIRCOUTCOMES.119.005597 4080:"Masculinizing Hormone Therapy" 3875:400–800 pg/mL (pre-orchiectomy) 3764: 3687: 3562:relative to the control group. 3366:as well as decreased fertility. 3267: 3244: 3115: 3096:can be used to slow or prevent 2934:DHT is common androgen used by 2570:high-density plasma lipoprotein 2551: 2467: 1919:Decreases the effectiveness of 1814: 1727:(elevated red blood cell count) 1558: 58:"Masculinizing hormone therapy" 34:needs additional citations for 8486:Norethisterone (norethindrone) 8331:Hydroxyprogesterone heptanoate 8255:Retroprogesterone derivatives: 8089:Ovandrotone albumin (Fecundin) 7275:) (via estrogenic metabolites) 7097:Ovandrotone albumin (Fecundin) 6569:norethisterone (norethindrone) 5935:Testosterone (as a medication) 5547:The Journal of Sexual Medicine 5195:"Standards of Care, Version 7" 4719:The Journal of Sexual Medicine 4268: 4217: 4176: 4135: 4086: 4072: 4048: 3970: 3814:Aspirin may decrease the risk. 3712:Transgender men who have been 3412:Human papillomavirus infection 3273:The action of testosterone on 3209:Growth of facial and body hair 3196:Increased red blood cell count 2984:gonadotropin-releasing hormone 2964:breast growth and hip widening 2658: 1937: 1636:Requirements and accessibility 1431:transmasculine hormone therapy 868:Cisgender / cissexual 863:Childhood gender nonconformity 489:Facial masculinization surgery 1: 9385:Masculinizing hormone therapy 8679:Tooltip Progesterone receptor 8229:Tooltip Progesterone receptor 6028:Testosterone phenylpropionate 5965:Masculinizing hormone therapy 5866:: a free online medical book. 4608:Current Clinical Pharmacology 4550:10.1016/S2213-8587(16)00036-X 3963: 3185:Alterations in blood lipids ( 3106:male-pattern body hair growth 2940:secondary sex characteristics 1958:and other routes) to produce 1427:Masculinizing hormone therapy 1345:Social construction of gender 9262:hydroxyprogesterone caproate 9001:Human chorionic gonadotropin 8996:Follicle-stimulating hormone 8598:Anabolic–androgenic steroids 8326:Hydroxyprogesterone caproate 8140:Estrogen receptor modulators 8041:hydroxyprogesterone caproate 7148:Androgen receptor modulators 7060:hydroxyprogesterone caproate 6523:Propetandrol (propethandrol) 6453:Tiomesterone (thiomesterone) 5960:Androgen replacement therapy 5369:10.1097/PAS.0000000000001486 4948:Patel A, Rivkees SA (2010). 4672:Journal of Clinical Medicine 4230:Journal of Clinical Medicine 3953:Androgen replacement therapy 3225:Growth spurt and closure of 2992:follicle-stimulating hormone 2809:androgen replacement therapy 2533:For prevention/treatment of 1970:levels, and prevent/reverse 1449:which is used to change the 917:Gender-sexuality questioning 7: 9359:Estrogens and antiestrogens 9354:Androgens and antiandrogens 9270:medroxyprogesterone acetate 8756:Estrogens and antiestrogens 8751:Androgens and antiandrogens 8336:Medroxyprogesterone acetate 8321:Hydroxyprogesterone acetate 8296:Chlormethenmadinone acetate 8145:Androgens and antiandrogens 8081:Androstenedione immunogens: 8045:medroxyprogesterone acetate 7688:Tooltip luteinizing hormone 7568:Doisynoestrol (fenocycline) 7153:Estrogens and antiestrogens 7089:Androstenedione immunogens: 7068:medroxyprogesterone acetate 6648:Tooltip luteinizing hormone 6593:Medroxyprogesterone acetate 6347:nandrolone phenylpropionate 6252:testosterone ester mixtures 6172:Androstenediol dipropionate 5930:Testosterone (as a hormone) 5870:Hudson's FTM Resource Guide 4777:Tucker ME (March 7, 2014). 4497:10.1007/978-3-030-05683-4_8 3916: 3858:Optimal trans female range 3725:estrogen to slow bone loss. 3129:medroxyprogesterone acetate 2797:nandrolone phenylpropionate 2717: 2590: 2354:Medroxyprogesterone acetate 1988:medroxyprogesterone acetate 1504:and a masculine pattern of 1471:transgender hormone therapy 482:Facial feminization surgery 10: 9401: 8066:Mixed mechanism of action: 7838:Noncompetitive inhibitors: 7590:Methestrol (promethestrol) 7445:Ethinylestradiol sulfonate 7018:ethinylestradiol sulfonate 5782:10.1152/ajpendo.00161.2017 5559:10.1016/j.jsxm.2017.11.004 5475:10.1016/j.ajog.2019.07.043 5424:10.1007/s00345-021-03907-y 5322:10.1016/j.ajog.2018.12.021 5145:Irwig MS (November 2021). 5110:10.1016/j.ijwd.2016.11.007 5092:Ginsberg BA (March 2017). 4874:10.1016/j.esxm.2020.01.009 4004:Unger CA (December 2016). 3958:Feminizing hormone therapy 3885: 3864: 3847: 3768: 3743: 3260:prescribed by a physician. 3167:Redistribution of body fat 3150: 3102:excessive body hair growth 2907:, oral activity, ratio of 2825:excessive body hair growth 2395:104mg every 3 months 2381:150mg every 3 months 2212:50–100mg once/week or 2188:50–100mg once/week or 1857:(antibiotic), and alcohol. 1639: 1594: 1590: 1483:transmasculine individuals 1475:feminizing hormone therapy 852:Androphilia and gynephilia 552:Gender self-identification 9307: 9133: 9037: 9028: 8977: 8912: 8836: 8818: 8707: 8672: 8644: 8635: 8585:Spirolactone derivatives: 8432:Testosterone derivatives: 8240:Progesterone derivatives: 8207: 8101: 8058: 7910: 7849: 7823:Exclusively antagonistic: 7717:Tooltip Estrogen receptor 7710: 7701: 7630: 7231:Tooltip Estrogen receptor 7224: 7215: 7109: 7081: 6943: 6880: 6842: 6831: 6686:Tooltip Androgen receptor 6679: 6670: 6601: 6590:Progesterone derivatives: 6202:Cloxotestosterone acetate 6169:Testosterone derivatives: 6158:Tooltip Androgen receptor 6151: 6131: 6051: 6043:Mixed testosterone esters 5973: 5922: 5700:10.1210/jcem.79.1.8027240 4458:10.1016/j.ecl.2019.01.004 4372:10.1007/s40618-014-0186-2 3861:Optimal trans male range 3544:randomized clinical trial 3360:polycystic ovary syndrome 3075: 3058:feminine fat distribution 2956:androgen backdoor pathway 2883:but carry a high risk of 2463: 2442: 2418: 2399: 2331: 2310: 2289: 2267: 2242:Mixed testosterone esters 2240: 2221: 2197: 2170: 2052: 2047: 2044: 2041: 2038: 2035: 1925:nonselective beta blocker 1787: 1469:. It is a common type of 226:Non-binary or genderqueer 8889:Leuprorelin (leuprolide) 8496:Norethisterone enanthate 7452:Hydroxyestrone diacetate 7379:estradiol ester mixtures 6473:Mebolazine (dimethazine) 6423:Methandriol dipropionate 6248:testosterone undecanoate 6038:Testosterone undecanoate 6023:Testosterone isocaproate 6018:Testosterone isobutyrate 5412:World Journal of Urology 4277:Neurology of Urodynamics 3651:Gastrointestinal changes 3494:Headaches: Pre-existing 2948:assigned female at birth 2614:testosterone undecanoate 2603:(Depo-Testosterone) and 2269:Testosterone undecanoate 2223:Testosterone isobutyrate 2054:Testosterone undecanoate 1520:, which may necessitate 1487:assigned female at birth 1447:gender affirming therapy 671:Parental rights movement 580:Political office-holders 459:Gender-affirming surgery 7617:Triphenylchloroethylene 7375:polyestradiol phosphate 6823:Topilutamide (fluridil) 6244:testosterone propionate 6033:Testosterone propionate 5950:Androgen (as a hormone) 4023:10.21037/tau.2016.09.04 3740:Obstructive sleep apnea 3584:Gender Dysphoria Clinic 3465:reproductive technology 3086:5α-Reductase inhibitors 3081:5α-Reductase inhibitors 2889:intramuscular injection 2726: 2622:Testosterone propionate 2574:low-density lipoprotein 2102:11mg three times daily 1996:5α-reductase inhibitors 1801:A 2022 review entitled 1756:Coronary artery disease 265: 198:Bissu, Calabai, Calalai 8491:Norethisterone acetate 8351:Methenmadinone acetate 7612:Triphenylbromoethylene 7389:Estramustine phosphate 6428:Methandriol propionate 6334:Bolandiol dipropionate 6240:testosterone enanthate 6236:testosterone cypionate 6177:Boldenone undecylenate 6013:Testosterone enanthate 6008:Testosterone decanoate 6003:Testosterone cypionate 5993:Testosterone buciclate 5723:Clinical Endocrinology 5274:10.1089/trgh.2017.0023 4585:10.1055/s-0029-1210600 4403:Clinical Endocrinology 4289:(inactive 2024-09-01). 3797:deep venous thrombosis 3571:Cardiovascular changes 3566:Health-related changes 3406:are advised to have a 3382:histologically active. 3206:Deepening of the voice 2733:gastrointestinal tract 2655: 2652:Testosterone cypionate 2605:testosterone enanthate 2601:testosterone cypionate 2576:levels, and increased 2199:Testosterone cypionate 2172:Testosterone enanthate 1812: 1662:This section is empty. 1613:This section is empty. 1366:Transgender portal 1335:Sex–gender distinction 894:Gender detransitioning 781:Anatomical terminology 9254:chlormadinone acetate 8361:Pentagestrone acetate 8291:Chlormadinone acetate 8029:chlormadinone acetate 7413:Estrogenic substances 7407:polyestriol phosphate 7307:Cloxestradiol acetate 7052:chlormadinone acetate 6713:Chlormadinone acetate 6284:Androstanolone esters 5998:Testosterone caproate 5655:10.1210/en.2017-00884 4329:10.1210/jc.2017-01658 3887:Testosterone (total) 3515:Psychological changes 3286:male pattern baldness 3216:(in some individuals) 3173:Increased musculature 2764:Alternative androgens 2748:Sublingual and buccal 2741:first-pass metabolism 2650: 2558:elimination half-life 2386:Depo-SubQ Provera 104 1853:(seizure medicines), 1830:system (specifically 1807: 1320:Queer heterosexuality 932:Rapid-onset dysphoria 715:Yogyakarta Principles 9266:gestonorone caproate 9102:Aromatase inhibitors 8761:List of progestogens 8531:Quingestanol acetate 8346:Melengestrol acetate 8316:Flumedroxone acetate 8037:gestonorone caproate 7851:Aromatase inhibitors 7534:Dienestrol diacetate 7482:Prasterone enanthate 7367:estradiol undecylate 7332:Esterified estrogens 7317:Conjugated estrogens 7064:gestonorone caproate 6872:Saw palmetto extract 6763:Potassium canrenoate 6358:Norclostebol acetate 6343:nandrolone decanoate 6197:Clostebol propionate 5516:(suppl_1): 107–114. 5316:(3): 257.e1–257.e7. 4678:(6). MDPI AG: 1609. 4489:Transgender Medicine 4112:10.1210/jc.2009-0345 3659:liver function tests 3548:testosterone therapy 3489:Neurological changes 3447:Reproductive changes 3201:Irreversible changes 3124:in transgender men. 3110:clitoral enlargement 3068:as well as increase 3038:aromatase inhibitors 2793:nandrolone decanoate 2291:Nandrolone decanoate 1567:Utilized to address 906:Gender transitioning 858:Blanchard's typology 786:Fictional characters 732:Events and awareness 638:Anti-gender movement 43:improve this article 9258:cyproterone acetate 9186:prolactin releasers 9006:Luteinizing hormone 8476:Etynodiol diacetate 8398:Nomegestrol acetate 8306:Delmadinone acetate 8301:Cyproterone acetate 8033:cyproterone acetate 7932:testosterone esters 7363:estradiol enanthate 7359:estradiol cypionate 7292:etynodiol diacetate 7261:testosterone esters 7056:cyproterone acetate 6964:prolactin releasers 6906:Cyproterone acetate 6888:Abiraterone acetate 6748:Nomegestrol acetate 6723:Delmadinone acetate 6718:Cyproterone acetate 6700:Abiraterone acetate 6232:Testosterone esters 5523:10.1530/eje.1.02248 5207:on January 28, 2014 4970:10.1155/2010/867471 4082:. 17 February 2022. 3893:225–900 ng/dL 3301:5α-reductase type 1 3279:dihydrotestosterone 3219:Enlargement of the 2988:luteinizing hormone 2978:In all people, the 2925:Dihydrotestosterone 2920:Dihydrotestosterone 2897:mechanism of action 2769:Synthetic androgens 2739:. In addition, the 2517:For suppression of 2236:50–100mg once/week 2032: 1998:to prevent/reverse 1902:protease inhibitors 1872:(antidepressants), 1708:Androgen-sensitive 1597:Transgender history 1300:Anti-LGBTQ rhetoric 845:Theory and concepts 727:Society and culture 708:Trans panic defense 9334:Never to phase III 9236:diethylstilbestrol 8734:Never to phase III 8664:Ulipristal acetate 8286:Anagestone acetate 8128:Never to phase III 7963:releasers) (e.g., 7874:Second-generation: 7487:Prasterone sulfate 7371:estradiol valerate 7355:estradiol benzoate 7312:Conjugated estriol 7265:methyltestosterone 7136:Never to phase III 7002:diethylstilbestrol 6629:GnRH (gonadorelin) 6433:Methyltestosterone 6368:Trenbolone acetate 6324:Stenbolone acetate 6289:Bolazine capronate 6192:Clostebol caproate 6064:Methyltestosterone 5988:Testosterone ester 5862:2016-11-30 at the 5262:Transgender Health 5164:10.1111/andr.12881 4935:transcare.ucsf.edu 4911:transcare.ucsf.edu 4685:10.3390/jcm9061609 4243:10.3390/jcm9061609 4060:www.mayoclinic.org 3982:transcare.ucsf.edu 3931:Transgender portal 3801:pulmonary embolism 3546:on the effects of 3496:migraine headaches 3379:endometrial cancer 3159:Reversible changes 3062:epiphyseal closure 3054:breast development 3021:permits GnRH from 2952:androgen receptors 2869:methyltestosterone 2656: 2572:levels, increased 2282:750–1,000mg every 2005: 1745:and fluid overload 1340:Sexual orientation 1179:Disenfranchisement 748:Day of Remembrance 649:trans-exclusionary 134:Transgender topics 9372: 9371: 9303: 9302: 9274:megestrol acetate 9165:nandrolone esters 9157:anabolic steroids 9135:Antigonadotropins 9024: 9023: 8973: 8972: 8769: 8768: 8703: 8702: 8631: 8630: 8390:17α-Hydroxylated: 8356:Osaterone acetate 8341:Megestrol acetate 8273:17α-Hydroxylated: 8163: 8162: 8155:List of estrogens 8097: 8096: 8049:megestrol acetate 7936:nandrolone esters 7924:anabolic steroids 7912:Antigonadotropins 7889:Third-generation: 7862:Aminoglutethimide 7859:First-generation: 7697: 7696: 7403:estriol succinate 7351:estradiol acetate 7273:nandrolone esters 7253:anabolic steroids 7171: 7170: 7105: 7104: 7072:megestrol acetate 6945:Antigonadotropins 6939: 6938: 6896:Aminoglutethimide 6753:Osaterone acetate 6743:Megestrol acetate 6666: 6665: 6339:Nandrolone esters 6187:Clostebol acetate 6087: 6086: 5826:978-1-56639-852-7 5586:JAMA Network Open 5242:978-0-9773250-0-9 5041:978-0-7637-3252-3 5014:978-3-88763-075-1 4731:10.1111/jsm.12698 4725:(12): 3002–3011. 4506:978-3-030-05683-4 4415:10.1111/cen.12753 4323:(11): 3869–3903. 4154:(11): 1461–1462. 3907: 3906: 3890:25–95 ng/dL 3866:Estrogen (total) 3852:Cis female range 3666:Metabolic changes 2805:androgen receptor 2781:anabolic steroids 2677:consistent supply 2618:patent protection 2549: 2548: 2088:30mg twice daily 1948:anabolic steroids 1900:antibiotics, and 1882:azole antifungals 1775:antiproliferative 1691:contraindications 1685:Contraindications 1682: 1681: 1633: 1632: 1424: 1423: 1270:elected officials 900:Gender expression 753:Day of Visibility 562:Non-binary gender 528:Standards of Care 185:Gender identities 119: 118: 111: 93: 9392: 9348: 9232:ethinylestradiol 9228:estradiol esters 9147: 9125: 9121: 9114: 9085: 9081: 9051: 9039:Progonadotropins 9035: 9034: 8984: 8983: 8849:Azagly-nafarelin 8834: 8833: 8822: 8809: 8805: 8796: 8789: 8782: 8773: 8772: 8680: 8676: 8652: 8648: 8642: 8641: 8637:Antiprogestogens 8380:Haloprogesterone 8230: 8226: 8220: 8219: 8201:antiprogestogens 8190: 8183: 8176: 8167: 8166: 8010: 7993: 7738: 7734: 7729: 7725: 7718: 7714: 7708: 7707: 7689: 7685: 7680: 7676: 7659: 7652: 7632:Progonadotropins 7578:Hexestrol esters 7524:Chlorotrianisene 7440:Ethinylestradiol 7347:Estradiol esters 7232: 7228: 7222: 7221: 7198: 7191: 7184: 7175: 7174: 7038:GnRH antagonists 7014:ethinylestradiol 7010:estradiol esters 6840: 6839: 6687: 6683: 6677: 6676: 6658: 6654: 6649: 6645: 6603:Progonadotropins 6268:Testoviron Depot 6159: 6155: 6149: 6148: 6144: 6140: 6114: 6107: 6100: 6091: 6090: 5909: 5902: 5895: 5886: 5885: 5838: 5837: 5835: 5833: 5810: 5804: 5803: 5793: 5776:(5): E540–E551. 5761: 5755: 5754: 5718: 5712: 5711: 5683: 5677: 5676: 5666: 5634: 5628: 5627: 5617: 5577: 5571: 5570: 5542: 5536: 5535: 5525: 5501: 5495: 5494: 5458: 5452: 5451: 5403: 5397: 5396: 5363:(8): 1040–1049. 5348: 5342: 5341: 5305: 5296: 5295: 5285: 5253: 5247: 5246: 5228: 5217: 5216: 5214: 5212: 5203:. Archived from 5191: 5185: 5184: 5166: 5157:(6): 1729–1731. 5142: 5136: 5135: 5121: 5089: 5078: 5077: 5066: 5060: 5059: 5052: 5046: 5045: 5025: 5019: 5018: 4999: 4993: 4992: 4982: 4972: 4954: 4945: 4939: 4938: 4927: 4921: 4920: 4918: 4917: 4903: 4897: 4896: 4886: 4876: 4852: 4846: 4845: 4843: 4841: 4827: 4821: 4820: 4818: 4816: 4802: 4796: 4795: 4793: 4791: 4774: 4768: 4767: 4765: 4763: 4749: 4743: 4742: 4714: 4708: 4707: 4697: 4687: 4663: 4657: 4656: 4654: 4652: 4646: 4638: 4632: 4631: 4603: 4597: 4596: 4568: 4562: 4561: 4533: 4527: 4526: 4484: 4478: 4477: 4441: 4435: 4434: 4398: 4392: 4391: 4355: 4349: 4348: 4311: 4305: 4304: 4298: 4290: 4288: 4286:10.1002/nau25094 4272: 4266: 4265: 4255: 4245: 4221: 4215: 4214: 4204: 4180: 4174: 4173: 4163: 4139: 4133: 4132: 4114: 4105:(9): 3132–3154. 4090: 4084: 4083: 4076: 4070: 4069: 4067: 4066: 4052: 4046: 4045: 4035: 4025: 4001: 3992: 3991: 3989: 3988: 3974: 3947: 3942: 3941: 3940: 3933: 3928: 3927: 3846: 3845: 3622:Type II diabetes 3410:per guidelines ( 3299:(but functional 3240:Physical changes 3164:Increased libido 3001:In adolescents, 2962:effects such as 2905:pharmacokinetics 2863:). AAS that are 2759: 2578:prothrombin time 2538: 2531: 2522: 2515: 2506: 2503: 2478: 2471: 2430: 2285: 2263: 2258: 2217: 2214:100–250mg every 2193: 2190:100–250mg every 2184: 2166: 2163:150–600mg every 2160: 2115: 2058:Andriol, Jatenzo 2033: 2026: 2019: 2012: 2004: 1904:(HIV treatment). 1819:Testosterone is 1783:(mild to severe) 1743:sodium retention 1695:androgen therapy 1677: 1674: 1664:You can help by 1657: 1650: 1628: 1625: 1615:You can help by 1608: 1601: 1545:gender dysphoria 1429:, also known as 1416: 1409: 1402: 1387: 1386: 1378:LGBTQ portal 1376: 1375: 1374: 1364: 1363: 1214: 1041: 908: 896: 854: 801:Media portrayals 654: 653: 652:radical feminism 650: 646: 598:Military service 530: 518: 501: 491: 484: 475: 468: 461: 451: 432: 422: 413: 406: 404:Gender dysphoria 399: 270: 154: 151: 148: 145: 142: 121: 120: 114: 107: 103: 100: 94: 92: 51: 27: 19: 9400: 9399: 9395: 9394: 9393: 9391: 9390: 9389: 9375: 9374: 9373: 9368: 9339: 9324:Clinical trials 9299: 9178: 9129: 9123: 9083: 9030: 9020: 8969: 8908: 8825: 8814: 8807: 8800: 8770: 8765: 8739: 8724:Clinical trials 8699: 8678: 8668: 8650: 8627: 8622:norethandrolone 8412:17α-Methylated: 8370:17α-Methylated: 8228: 8211: 8203: 8194: 8164: 8159: 8133: 8118:Clinical trials 8093: 8054: 7953: 7944:fluoxymesterone 7906: 7845: 7736: 7727: 7720: 7716: 7693: 7687: 7678: 7626: 7585:Methallenestril 7462:Methylestradiol 7428:Estrone sulfate 7230: 7211: 7202: 7172: 7167: 7141: 7126:Clinical trials 7101: 7077: 6956: 6935: 6876: 6834: 6833:Steroidogenesis 6827: 6685: 6662: 6656: 6647: 6597: 6513:Norethandrolone 6398:Fluoxymesterone 6157: 6142: 6135: 6127: 6118: 6088: 6083: 6047: 5969: 5918: 5913: 5864:Wayback Machine 5847: 5842: 5841: 5831: 5829: 5827: 5811: 5807: 5762: 5758: 5719: 5715: 5684: 5680: 5635: 5631: 5592:(9): e2331919. 5578: 5574: 5543: 5539: 5502: 5498: 5459: 5455: 5404: 5400: 5349: 5345: 5306: 5299: 5254: 5250: 5243: 5229: 5220: 5210: 5208: 5193: 5192: 5188: 5143: 5139: 5090: 5081: 5068: 5067: 5063: 5054: 5053: 5049: 5042: 5026: 5022: 5015: 5001: 5000: 4996: 4952: 4946: 4942: 4929: 4928: 4924: 4915: 4913: 4905: 4904: 4900: 4861:Sexual Medicine 4853: 4849: 4839: 4837: 4835:medlineplus.gov 4829: 4828: 4824: 4814: 4812: 4804: 4803: 4799: 4789: 4787: 4775: 4771: 4761: 4759: 4751: 4750: 4746: 4715: 4711: 4664: 4660: 4650: 4648: 4644: 4640: 4639: 4635: 4604: 4600: 4569: 4565: 4534: 4530: 4507: 4485: 4481: 4442: 4438: 4399: 4395: 4356: 4352: 4312: 4308: 4292: 4291: 4273: 4269: 4222: 4218: 4181: 4177: 4140: 4136: 4091: 4087: 4078: 4077: 4073: 4064: 4062: 4054: 4053: 4049: 4002: 3995: 3986: 3984: 3976: 3975: 3971: 3966: 3945:Medicine portal 3943: 3938: 3936: 3929: 3922: 3919: 3902: 3897: 3881: 3876: 3855:Cis male range 3821: 3773: 3767: 3748: 3742: 3714:oophorectomized 3690: 3668: 3653: 3573: 3568: 3517: 3491: 3449: 3422:vaginal atrophy 3341: 3310: 3270: 3247: 3242: 3153: 3141: 3118: 3108:, and possibly 3098:scalp hair loss 3083: 3078: 3048:(SERMs) (e.g., 3031: 3012:pituitary gland 2976: 2946:(who are often 2922: 2859:effects (e.g., 2829:scalp hair loss 2771: 2766: 2757: 2750: 2737:HDL cholesterol 2729: 2720: 2696:The cost varies 2661: 2593: 2554: 2544: 2542: 2541: 2535:scalp hair loss 2532: 2525: 2516: 2509: 2504: 2481: 2472: 2468: 2341:GnRH antagonist 2283: 2261: 2259: 2256: 2215: 2213: 2191: 2189: 2164: 2030: 2000:scalp hair loss 1960:masculinization 1940: 1825:cytochrome P450 1817: 1790: 1741:susceptible to 1731:Cardiac failure 1687: 1678: 1672: 1669: 1648: 1640:Main articles: 1638: 1629: 1623: 1620: 1599: 1593: 1561: 1549:gender identity 1502:voice deepening 1479:transgender men 1473:(another being 1443:hormone therapy 1420: 1382: 1372: 1370: 1358: 1350: 1349: 1295: 1287: 1286: 1208: 1202: 1195: 1035: 980: 974: 964: 963: 954:Transmedicalism 922:Gender variance 912:Gender identity 904: 892: 850: 846: 838: 837: 777: 772: 743:Beauty pageants 734: 728: 720: 719: 676:Transgender men 651: 648: 645:Gender-critical 644: 643: 634: 584: 570:Rights movement 566: 547: 536: 535: 526: 514: 497: 494: 487: 480: 471: 464: 457: 454: 447: 430:Hormone therapy 428: 425: 418: 409: 402: 395: 391: 380: 379: 231:Gender fluidity 187: 177: 152: 149: 146: 143: 140: 115: 104: 98: 95: 52: 50: 40: 28: 17: 12: 11: 5: 9398: 9388: 9387: 9370: 9369: 9367: 9366: 9361: 9356: 9351: 9343: 9338: 9337: 9336: 9335: 9332: 9321: 9315: 9309: 9308: 9305: 9304: 9301: 9300: 9298: 9297: 9292: 9287: 9278: 9277: 9243: 9240:paroxypropione 9213: 9206:chlorpromazine 9194:metoclopramide 9176: 9172: 9139: 9137: 9131: 9130: 9128: 9127: 9109: 9099: 9072: 9043: 9041: 9032: 9026: 9025: 9022: 9021: 9019: 9018: 9016:Urofollitropin 9013: 9008: 9003: 8998: 8992: 8990: 8981: 8975: 8974: 8971: 8970: 8968: 8967: 8957: 8952: 8943: 8942: 8937: 8932: 8927: 8918: 8916: 8910: 8909: 8907: 8906: 8901: 8896: 8891: 8886: 8881: 8876: 8871: 8866: 8861: 8856: 8851: 8842: 8840: 8831: 8816: 8815: 8799: 8798: 8791: 8784: 8776: 8767: 8766: 8764: 8763: 8758: 8753: 8748: 8743: 8738: 8737: 8736: 8735: 8732: 8721: 8715: 8709: 8708: 8705: 8704: 8701: 8700: 8698: 8697: 8692: 8686: 8684: 8670: 8669: 8667: 8666: 8661: 8655: 8653: 8639: 8633: 8632: 8629: 8628: 8626: 8625: 8591: 8590: 8581: 8580: 8575: 8570: 8568:Norelgestromin 8565: 8563:Levonorgestrel 8560: 8555: 8550: 8545: 8533: 8528: 8523: 8521:Norvinisterone 8518: 8513: 8511:Norgestrienone 8508: 8503: 8498: 8493: 8488: 8483: 8478: 8473: 8468: 8463: 8451: 8450: 8445: 8443:Dimethisterone 8440: 8428: 8427: 8422: 8417: 8405: 8400: 8395: 8383: 8382: 8363: 8358: 8353: 8348: 8343: 8338: 8333: 8328: 8323: 8318: 8313: 8308: 8303: 8298: 8293: 8288: 8283: 8278: 8266: 8265: 8260: 8258:Dydrogesterone 8251: 8250: 8245: 8236: 8234: 8217: 8205: 8204: 8193: 8192: 8185: 8178: 8170: 8161: 8160: 8158: 8157: 8152: 8147: 8142: 8137: 8132: 8131: 8130: 8129: 8126: 8115: 8109: 8103: 8102: 8099: 8098: 8095: 8094: 8092: 8091: 8086: 8077: 8076: 8071: 8062: 8060: 8056: 8055: 8053: 8052: 8022: 8005: 7988: 7981:chlorpromazine 7969:metoclopramide 7951: 7947: 7916: 7914: 7908: 7907: 7905: 7904: 7899: 7894: 7885: 7884: 7879: 7870: 7869: 7864: 7855: 7853: 7847: 7846: 7844: 7843: 7834: 7833: 7828: 7819: 7818: 7813: 7808: 7803: 7798: 7793: 7788: 7783: 7778: 7773: 7768: 7763: 7758: 7753: 7748: 7742: 7740: 7705: 7699: 7698: 7695: 7694: 7692: 7691: 7667: 7647: 7636: 7634: 7628: 7627: 7625: 7624: 7619: 7614: 7609: 7604: 7602:Paroxypropione 7599: 7598: 7597: 7587: 7582: 7581: 7580: 7570: 7565: 7564: 7563: 7558: 7553: 7543: 7538: 7537: 7536: 7526: 7521: 7516: 7507: 7506: 7501: 7496: 7491: 7490: 7489: 7484: 7474: 7469: 7464: 7459: 7454: 7449: 7448: 7447: 7437: 7436: 7435: 7430: 7423:Estrone esters 7420: 7415: 7410: 7399:Estriol esters 7396: 7391: 7386: 7344: 7339: 7334: 7329: 7324: 7319: 7314: 7309: 7304: 7299: 7284:norethisterone 7276: 7245: 7236: 7234: 7219: 7213: 7212: 7201: 7200: 7193: 7186: 7178: 7169: 7168: 7166: 7165: 7160: 7155: 7150: 7145: 7140: 7139: 7138: 7137: 7134: 7123: 7117: 7111: 7110: 7107: 7106: 7103: 7102: 7100: 7099: 7094: 7085: 7083: 7079: 7078: 7076: 7075: 7045: 7035: 7025: 7022:paroxypropione 6991: 6984:chlorpromazine 6972:metoclopramide 6954: 6949: 6947: 6941: 6940: 6937: 6936: 6934: 6933: 6931:Spironolactone 6928: 6923: 6918: 6913: 6908: 6903: 6898: 6893: 6884: 6882: 6878: 6877: 6875: 6874: 6869: 6864: 6859: 6854: 6848: 6846: 6837: 6829: 6828: 6826: 6825: 6820: 6815: 6810: 6805: 6800: 6795: 6790: 6785: 6780: 6771: 6770: 6768:Spironolactone 6765: 6760: 6755: 6750: 6745: 6740: 6735: 6730: 6725: 6720: 6715: 6710: 6705: 6693: 6691: 6674: 6668: 6667: 6664: 6663: 6661: 6660: 6636: 6622: 6607: 6605: 6599: 6598: 6596: 6595: 6586: 6585: 6580: 6577:norgestrienone 6561:levonorgestrel 6550: 6545: 6536: 6535: 6526: 6525: 6520: 6515: 6510: 6505: 6496: 6495: 6490: 6485: 6480: 6475: 6470: 6465: 6463:Androisoxazole 6456: 6455: 6450: 6445: 6440: 6435: 6430: 6425: 6420: 6415: 6410: 6405: 6400: 6395: 6390: 6385: 6376: 6375: 6370: 6365: 6360: 6355: 6350: 6336: 6327: 6326: 6321: 6316: 6311: 6306: 6301: 6296: 6291: 6286: 6281: 6272: 6271: 6229: 6224: 6219: 6214: 6209: 6204: 6199: 6194: 6189: 6184: 6179: 6174: 6165: 6163: 6146: 6129: 6128: 6117: 6116: 6109: 6102: 6094: 6085: 6084: 6082: 6081: 6076: 6071: 6066: 6061: 6055: 6053: 6049: 6048: 6046: 6045: 6040: 6035: 6030: 6025: 6020: 6015: 6010: 6005: 6000: 5995: 5990: 5985: 5983:Androgen ester 5979: 5977: 5971: 5970: 5968: 5967: 5962: 5957: 5952: 5947: 5942: 5937: 5932: 5926: 5924: 5920: 5919: 5912: 5911: 5904: 5897: 5889: 5883: 5882: 5873: 5867: 5854: 5846: 5845:External links 5843: 5840: 5839: 5825: 5805: 5756: 5729:(3): 347–354. 5713: 5694:(1): 265–271. 5678: 5649:(2): 754–762. 5629: 5572: 5537: 5496: 5469:(2): 134–143. 5453: 5418:(3): 849–855. 5398: 5343: 5297: 5268:(1): 176–179. 5248: 5241: 5218: 5186: 5137: 5079: 5061: 5047: 5040: 5020: 5013: 4994: 4940: 4922: 4898: 4867:(2): 237–242. 4847: 4822: 4797: 4769: 4744: 4709: 4658: 4647:. 24 July 2018 4633: 4598: 4563: 4544:(4): 301–311. 4528: 4505: 4479: 4452:(2): 357–375. 4436: 4409:(5): 597–606. 4393: 4350: 4306: 4267: 4216: 4195:(4): e005597. 4175: 4134: 4085: 4071: 4047: 4016:(6): 877–884. 3993: 3968: 3967: 3965: 3962: 3961: 3960: 3955: 3949: 3948: 3934: 3918: 3915: 3905: 3904: 3899: 3894: 3891: 3888: 3884: 3883: 3878: 3873: 3872:< 40 pg/mL 3870: 3867: 3863: 3862: 3859: 3856: 3853: 3850: 3820: 3819:Hormone levels 3817: 3816: 3815: 3812: 3793: 3789: 3786: 3783: 3780: 3777: 3769:Main article: 3766: 3763: 3762: 3761: 3758: 3755: 3752: 3744:Main article: 3741: 3738: 3737: 3736: 3733: 3729: 3726: 3710: 3707: 3704: 3701: 3698: 3689: 3686: 3685: 3684: 3680: 3676: 3673: 3667: 3664: 3663: 3662: 3652: 3649: 3648: 3647: 3643: 3636: 3632: 3629: 3625: 3614: 3607: 3596: 3577: 3572: 3569: 3567: 3564: 3516: 3513: 3512: 3511: 3508: 3505: 3499: 3490: 3487: 3486: 3485: 3484: 3483: 3479: 3475: 3468: 3453: 3448: 3445: 3444: 3443: 3432: 3429: 3418: 3415: 3398:Adults with a 3391: 3390: 3383: 3375: 3367: 3356: 3349: 3340: 3337: 3336: 3335: 3331: 3327: 3324: 3321: 3317: 3309: 3308:Facial changes 3306: 3305: 3304: 3289: 3282: 3269: 3266: 3265: 3264: 3261: 3257: 3254: 3251: 3246: 3243: 3241: 3238: 3237: 3236: 3233:Breast atrophy 3230: 3223: 3217: 3210: 3207: 3203: 3202: 3198: 3197: 3194: 3183: 3180: 3177: 3174: 3171: 3168: 3165: 3161: 3160: 3152: 3149: 3145:growth hormone 3140: 3139:Growth hormone 3137: 3117: 3114: 3082: 3079: 3077: 3074: 3030: 3027: 3003:GnRH analogues 2975: 2972: 2921: 2918: 2821:hair follicles 2770: 2767: 2765: 2762: 2749: 2746: 2728: 2725: 2719: 2716: 2667:, creams, and 2660: 2657: 2592: 2589: 2566:lean body mass 2553: 2550: 2547: 2546: 2540: 2539: 2523: 2507: 2479: 2465: 2464: 2461: 2460: 2457: 2454: 2449: 2446: 2440: 2439: 2436: 2433: 2425: 2422: 2416: 2415: 2412: 2409: 2406: 2403: 2397: 2396: 2393: 2390: 2387: 2383: 2382: 2379: 2376: 2373: 2369: 2368: 2365: 2362: 2359: 2356: 2350: 2349: 2346: 2343: 2338: 2335: 2329: 2328: 2325: 2322: 2320:GnRH modulator 2317: 2314: 2312:GnRH analogues 2308: 2307: 2304: 2301: 2296: 2295:Deca-Durabolin 2293: 2287: 2286: 2280: 2277: 2274: 2271: 2265: 2264: 2253: 2250: 2247: 2244: 2238: 2237: 2234: 2231: 2228: 2227:Agovirin Depot 2225: 2219: 2218: 2210: 2207: 2204: 2201: 2195: 2194: 2186: 2180: 2177: 2174: 2168: 2167: 2161: 2156: 2153: 2149: 2148: 2145: 2142: 2139: 2135: 2134: 2131: 2128: 2125: 2121: 2120: 2117: 2111: 2108: 2104: 2103: 2100: 2097: 2094: 2090: 2089: 2086: 2083: 2080: 2077: 2071: 2070: 2067: 2064: 2059: 2056: 2050: 2049: 2046: 2043: 2040: 2037: 2029: 2028: 2021: 2014: 2006: 1939: 1936: 1932: 1931: 1928: 1917: 1906: 1905: 1894:Clarithromycin 1858: 1816: 1813: 1789: 1786: 1785: 1784: 1778: 1771: 1768: 1765: 1763:uterine cancer 1759: 1753: 1746: 1728: 1722: 1717: 1712: 1686: 1683: 1680: 1679: 1660: 1658: 1637: 1634: 1631: 1630: 1624:September 2024 1611: 1609: 1595:Main article: 1592: 1589: 1585: 1584: 1581: 1578: 1575: 1572: 1565: 1560: 1557: 1534:GnRH analogues 1435:female-to-male 1422: 1421: 1419: 1418: 1411: 1404: 1396: 1393: 1392: 1381: 1380: 1368: 1355: 1352: 1351: 1348: 1347: 1342: 1337: 1332: 1327: 1322: 1317: 1312: 1310:Gender studies 1307: 1302: 1296: 1293: 1292: 1289: 1288: 1285: 1284: 1283: 1282: 1277: 1275:Cafeteria riot 1272: 1267: 1257: 1255:United Kingdom 1252: 1247: 1242: 1237: 1232: 1227: 1226: 1225: 1215: 1196: 1194: 1193: 1192: 1191: 1186: 1181: 1171: 1170: 1169: 1164: 1157:United Kingdom 1154: 1153: 1152: 1144: 1139: 1138: 1137: 1129: 1124: 1123: 1122: 1114: 1109: 1108: 1107: 1102: 1094: 1089: 1084: 1083: 1082: 1077: 1072: 1064: 1063: 1062: 1057: 1052: 1042: 1030: 1025: 1020: 1019: 1018: 1008: 1003: 998: 997: 996: 991: 976: 975: 970: 969: 966: 965: 962: 961: 956: 951: 950: 949: 939: 934: 929: 924: 919: 914: 909: 902: 897: 890: 885: 880: 878:Cross-dressing 875: 873:Cisnormativity 870: 865: 860: 855: 847: 844: 843: 840: 839: 836: 835: 830: 825: 820: 815: 814: 813: 803: 798: 793: 788: 783: 773: 771: 770: 765: 760: 755: 750: 745: 740: 738:Awareness Week 730: 729: 726: 725: 722: 721: 718: 717: 712: 711: 710: 705: 695: 690: 685: 684: 683: 678: 673: 668: 661:Discrimination 658: 657: 656: 633: 632: 631: 630: 625: 623:Bathroom bills 617: 612: 611: 610: 605: 595: 590: 583: 582: 577: 572: 565: 564: 559: 554: 548: 542: 541: 538: 537: 534: 533: 532: 531: 519: 512: 507: 502: 493: 492: 485: 478: 477: 476: 473:male-to-female 469: 466:female-to-male 453: 452: 445: 444: 443: 438: 424: 423: 420:Sex assignment 416: 415: 414: 400: 392: 386: 385: 382: 381: 378: 377: 372: 371: 370: 363: 353: 352: 351: 344: 337: 327: 322: 321: 320: 315: 308: 303: 298: 293: 288: 283: 276: 271: 262: 257: 247: 242: 235: 234: 233: 223: 218: 213: 208: 201: 194: 188: 183: 182: 179: 178: 176: 175: 170: 165: 159: 156: 155: 137: 136: 130: 129: 117: 116: 31: 29: 22: 15: 9: 6: 4: 3: 2: 9397: 9386: 9383: 9382: 9380: 9365: 9362: 9360: 9357: 9355: 9352: 9350: 9344: 9341: 9340: 9333: 9331: 9328: 9327: 9325: 9322: 9319: 9316: 9314: 9311: 9310: 9306: 9296: 9293: 9291: 9288: 9286: 9283: 9280: 9279: 9275: 9271: 9267: 9263: 9259: 9255: 9251: 9247: 9244: 9241: 9237: 9233: 9229: 9225: 9221: 9217: 9214: 9211: 9207: 9203: 9199: 9195: 9191: 9187: 9183: 9180: 9173: 9170: 9166: 9162: 9158: 9154: 9151: 9149: 9141: 9140: 9138: 9136: 9132: 9122: 9116: 9110: 9107: 9103: 9100: 9097: 9093: 9089: 9082: 9076: 9075:Antiestrogens 9073: 9070: 9066: 9062: 9058: 9057:Antiandrogens 9055: 9053: 9045: 9044: 9042: 9040: 9036: 9033: 9027: 9017: 9014: 9012: 9009: 9007: 9004: 9002: 8999: 8997: 8994: 8993: 8991: 8989: 8985: 8982: 8980: 8979:Gonadotropins 8976: 8965: 8961: 8958: 8956: 8953: 8951: 8948: 8945: 8944: 8941: 8938: 8936: 8933: 8931: 8928: 8926: 8923: 8920: 8919: 8917: 8915: 8911: 8905: 8902: 8900: 8897: 8895: 8892: 8890: 8887: 8885: 8882: 8880: 8877: 8875: 8872: 8870: 8867: 8865: 8862: 8860: 8857: 8855: 8852: 8850: 8847: 8844: 8843: 8841: 8839: 8835: 8832: 8829: 8824: 8817: 8813: 8812:gonadotropins 8806: 8797: 8792: 8790: 8785: 8783: 8778: 8777: 8774: 8762: 8759: 8757: 8754: 8752: 8749: 8747: 8744: 8741: 8740: 8733: 8731: 8728: 8727: 8725: 8722: 8719: 8716: 8714: 8711: 8710: 8706: 8696: 8693: 8691: 8688: 8687: 8685: 8683: 8677: 8671: 8665: 8662: 8660: 8657: 8656: 8654: 8649: 8643: 8640: 8638: 8634: 8623: 8619: 8618:ethylestrenol 8615: 8611: 8607: 8603: 8599: 8596: 8593: 8592: 8589: 8586: 8583: 8582: 8579: 8576: 8574: 8571: 8569: 8566: 8564: 8561: 8559: 8556: 8554: 8551: 8549: 8546: 8544: 8541: 8537: 8534: 8532: 8529: 8527: 8524: 8522: 8519: 8517: 8514: 8512: 8509: 8507: 8504: 8502: 8499: 8497: 8494: 8492: 8489: 8487: 8484: 8482: 8479: 8477: 8474: 8472: 8469: 8467: 8464: 8462: 8461:Allylestrenol 8459: 8456: 8453: 8452: 8449: 8446: 8444: 8441: 8439: 8436: 8433: 8430: 8429: 8426: 8423: 8421: 8418: 8416: 8413: 8409: 8406: 8404: 8401: 8399: 8396: 8394: 8391: 8388: 8385: 8384: 8381: 8378: 8374: 8371: 8367: 8364: 8362: 8359: 8357: 8354: 8352: 8349: 8347: 8344: 8342: 8339: 8337: 8334: 8332: 8329: 8327: 8324: 8322: 8319: 8317: 8314: 8312: 8309: 8307: 8304: 8302: 8299: 8297: 8294: 8292: 8289: 8287: 8284: 8282: 8279: 8277: 8274: 8271: 8268: 8267: 8264: 8261: 8259: 8256: 8253: 8252: 8249: 8246: 8244: 8241: 8238: 8237: 8235: 8233: 8227: 8221: 8218: 8215: 8210: 8206: 8202: 8198: 8191: 8186: 8184: 8179: 8177: 8172: 8171: 8168: 8156: 8153: 8151: 8148: 8146: 8143: 8141: 8138: 8135: 8134: 8127: 8125: 8122: 8121: 8119: 8116: 8113: 8110: 8108: 8105: 8104: 8100: 8090: 8087: 8085: 8082: 8079: 8078: 8075: 8072: 8070: 8067: 8064: 8063: 8061: 8057: 8050: 8046: 8042: 8038: 8034: 8030: 8026: 8023: 8020: 8016: 8012: 8006: 8003: 7999: 7995: 7989: 7986: 7982: 7978: 7974: 7970: 7966: 7962: 7958: 7955: 7948: 7945: 7941: 7937: 7933: 7929: 7925: 7921: 7918: 7917: 7915: 7913: 7909: 7903: 7900: 7898: 7895: 7893: 7890: 7887: 7886: 7883: 7880: 7878: 7875: 7872: 7871: 7868: 7865: 7863: 7860: 7857: 7856: 7854: 7852: 7848: 7842: 7839: 7836: 7835: 7832: 7829: 7827: 7824: 7821: 7820: 7817: 7814: 7812: 7809: 7807: 7804: 7802: 7799: 7797: 7794: 7792: 7789: 7787: 7784: 7782: 7779: 7777: 7774: 7772: 7769: 7767: 7764: 7762: 7759: 7757: 7754: 7752: 7749: 7747: 7744: 7743: 7741: 7735: 7726: 7715: 7709: 7706: 7704: 7703:Antiestrogens 7700: 7686: 7677: 7671: 7670:Gonadotropins 7668: 7665: 7661: 7660:(gonadorelin) 7654: 7648: 7645: 7641: 7640:Antiandrogens 7638: 7637: 7635: 7633: 7629: 7623: 7620: 7618: 7615: 7613: 7610: 7608: 7605: 7603: 7600: 7596: 7593: 7592: 7591: 7588: 7586: 7583: 7579: 7576: 7575: 7574: 7571: 7569: 7566: 7562: 7559: 7557: 7554: 7552: 7549: 7548: 7547: 7544: 7542: 7539: 7535: 7532: 7531: 7530: 7527: 7525: 7522: 7520: 7517: 7515: 7512: 7511:Nonsteroidal: 7509: 7508: 7505: 7502: 7500: 7497: 7495: 7492: 7488: 7485: 7483: 7480: 7479: 7478: 7475: 7473: 7470: 7468: 7465: 7463: 7460: 7458: 7455: 7453: 7450: 7446: 7443: 7442: 7441: 7438: 7434: 7431: 7429: 7426: 7425: 7424: 7421: 7419: 7416: 7414: 7411: 7408: 7404: 7400: 7397: 7395: 7392: 7390: 7387: 7384: 7380: 7376: 7372: 7368: 7364: 7360: 7356: 7352: 7348: 7345: 7343: 7340: 7338: 7335: 7333: 7330: 7328: 7325: 7323: 7320: 7318: 7315: 7313: 7310: 7308: 7305: 7303: 7300: 7297: 7293: 7289: 7285: 7281: 7277: 7274: 7270: 7266: 7262: 7258: 7254: 7250: 7246: 7244: 7241: 7238: 7237: 7235: 7229: 7223: 7220: 7218: 7214: 7210: 7209:antiestrogens 7206: 7199: 7194: 7192: 7187: 7185: 7180: 7179: 7176: 7164: 7161: 7159: 7156: 7154: 7151: 7149: 7146: 7143: 7142: 7135: 7133: 7130: 7129: 7127: 7124: 7121: 7118: 7116: 7113: 7112: 7108: 7098: 7095: 7093: 7090: 7087: 7086: 7084: 7080: 7073: 7069: 7065: 7061: 7057: 7053: 7049: 7046: 7043: 7039: 7036: 7033: 7029: 7028:GnRH agonists 7026: 7023: 7019: 7015: 7011: 7007: 7003: 6999: 6995: 6992: 6989: 6985: 6981: 6977: 6973: 6969: 6965: 6961: 6958: 6951: 6950: 6948: 6946: 6942: 6932: 6929: 6927: 6924: 6922: 6919: 6917: 6914: 6912: 6909: 6907: 6904: 6902: 6899: 6897: 6894: 6892: 6889: 6886: 6885: 6883: 6879: 6873: 6870: 6868: 6865: 6863: 6860: 6858: 6855: 6853: 6850: 6849: 6847: 6845: 6841: 6838: 6836: 6830: 6824: 6821: 6819: 6816: 6814: 6811: 6809: 6806: 6804: 6801: 6799: 6796: 6794: 6791: 6789: 6786: 6784: 6781: 6779: 6776: 6775:Nonsteroidal: 6773: 6772: 6769: 6766: 6764: 6761: 6759: 6756: 6754: 6751: 6749: 6746: 6744: 6741: 6739: 6736: 6734: 6731: 6729: 6726: 6724: 6721: 6719: 6716: 6714: 6711: 6709: 6706: 6704: 6701: 6698: 6695: 6694: 6692: 6690: 6684: 6678: 6675: 6673: 6672:Antiandrogens 6669: 6655: 6646: 6640: 6639:Gonadotropins 6637: 6634: 6630: 6626: 6625:GnRH agonists 6623: 6620: 6616: 6612: 6611:Antiestrogens 6609: 6608: 6606: 6604: 6600: 6594: 6591: 6588: 6587: 6584: 6581: 6578: 6574: 6570: 6566: 6562: 6558: 6554: 6551: 6549: 6546: 6544: 6541: 6538: 6537: 6534: 6531: 6528: 6527: 6524: 6521: 6519: 6516: 6514: 6511: 6509: 6506: 6504: 6503:Ethylestrenol 6501: 6498: 6497: 6494: 6491: 6489: 6486: 6484: 6481: 6479: 6476: 6474: 6471: 6469: 6466: 6464: 6461: 6458: 6457: 6454: 6451: 6449: 6446: 6444: 6441: 6439: 6436: 6434: 6431: 6429: 6426: 6424: 6421: 6419: 6416: 6414: 6411: 6409: 6406: 6404: 6401: 6399: 6396: 6394: 6391: 6389: 6386: 6384: 6381: 6378: 6377: 6374: 6371: 6369: 6366: 6364: 6361: 6359: 6356: 6354: 6351: 6348: 6344: 6340: 6337: 6335: 6332: 6329: 6328: 6325: 6322: 6320: 6317: 6315: 6312: 6310: 6307: 6305: 6302: 6300: 6297: 6295: 6292: 6290: 6287: 6285: 6282: 6280: 6277: 6274: 6273: 6269: 6265: 6261: 6257: 6253: 6249: 6245: 6241: 6237: 6233: 6230: 6228: 6225: 6223: 6220: 6218: 6215: 6213: 6210: 6208: 6205: 6203: 6200: 6198: 6195: 6193: 6190: 6188: 6185: 6183: 6180: 6178: 6175: 6173: 6170: 6167: 6166: 6164: 6162: 6156: 6150: 6147: 6141: 6134: 6130: 6126: 6125:antiandrogens 6122: 6115: 6110: 6108: 6103: 6101: 6096: 6095: 6092: 6080: 6077: 6075: 6072: 6070: 6067: 6065: 6062: 6060: 6057: 6056: 6054: 6050: 6044: 6041: 6039: 6036: 6034: 6031: 6029: 6026: 6024: 6021: 6019: 6016: 6014: 6011: 6009: 6006: 6004: 6001: 5999: 5996: 5994: 5991: 5989: 5986: 5984: 5981: 5980: 5978: 5976: 5972: 5966: 5963: 5961: 5958: 5956: 5953: 5951: 5948: 5946: 5943: 5941: 5938: 5936: 5933: 5931: 5928: 5927: 5925: 5921: 5917: 5910: 5905: 5903: 5898: 5896: 5891: 5890: 5887: 5881: 5877: 5874: 5871: 5868: 5865: 5861: 5858: 5855: 5852: 5849: 5848: 5828: 5822: 5818: 5817: 5809: 5801: 5797: 5792: 5787: 5783: 5779: 5775: 5771: 5767: 5760: 5752: 5748: 5744: 5740: 5736: 5732: 5728: 5724: 5717: 5709: 5705: 5701: 5697: 5693: 5689: 5682: 5674: 5670: 5665: 5660: 5656: 5652: 5648: 5644: 5643:Endocrinology 5640: 5633: 5625: 5621: 5616: 5611: 5607: 5603: 5599: 5595: 5591: 5587: 5583: 5576: 5568: 5564: 5560: 5556: 5553:(1): 94–101. 5552: 5548: 5541: 5533: 5529: 5524: 5519: 5515: 5511: 5507: 5500: 5492: 5488: 5484: 5480: 5476: 5472: 5468: 5464: 5457: 5449: 5445: 5441: 5437: 5433: 5429: 5425: 5421: 5417: 5413: 5409: 5402: 5394: 5390: 5386: 5382: 5378: 5374: 5370: 5366: 5362: 5358: 5354: 5347: 5339: 5335: 5331: 5327: 5323: 5319: 5315: 5311: 5304: 5302: 5293: 5289: 5284: 5279: 5275: 5271: 5267: 5263: 5259: 5252: 5244: 5238: 5234: 5227: 5225: 5223: 5206: 5202: 5201: 5196: 5190: 5182: 5178: 5174: 5170: 5165: 5160: 5156: 5152: 5148: 5141: 5134: 5129: 5125: 5120: 5115: 5111: 5107: 5103: 5099: 5095: 5088: 5086: 5084: 5075: 5071: 5065: 5057: 5051: 5043: 5037: 5033: 5032: 5024: 5016: 5010: 5006: 5005: 4998: 4990: 4986: 4981: 4976: 4971: 4966: 4962: 4958: 4951: 4944: 4936: 4932: 4926: 4912: 4908: 4902: 4894: 4890: 4885: 4880: 4875: 4870: 4866: 4862: 4858: 4851: 4836: 4832: 4826: 4811: 4807: 4801: 4786: 4785: 4780: 4773: 4758: 4754: 4748: 4740: 4736: 4732: 4728: 4724: 4720: 4713: 4705: 4701: 4696: 4691: 4686: 4681: 4677: 4673: 4669: 4662: 4643: 4637: 4629: 4625: 4621: 4617: 4613: 4609: 4602: 4594: 4590: 4586: 4582: 4579:(2): 219–23. 4578: 4574: 4567: 4559: 4555: 4551: 4547: 4543: 4539: 4532: 4524: 4520: 4516: 4512: 4508: 4502: 4498: 4494: 4490: 4483: 4475: 4471: 4467: 4463: 4459: 4455: 4451: 4447: 4440: 4432: 4428: 4424: 4420: 4416: 4412: 4408: 4404: 4397: 4389: 4385: 4381: 4377: 4373: 4369: 4366:(3): 269–82. 4365: 4361: 4354: 4346: 4342: 4338: 4334: 4330: 4326: 4322: 4318: 4310: 4302: 4296: 4287: 4282: 4278: 4271: 4263: 4259: 4254: 4249: 4244: 4239: 4235: 4231: 4227: 4220: 4212: 4208: 4203: 4198: 4194: 4190: 4186: 4179: 4171: 4167: 4162: 4157: 4153: 4149: 4145: 4138: 4130: 4126: 4122: 4118: 4113: 4108: 4104: 4100: 4096: 4089: 4081: 4075: 4061: 4057: 4051: 4043: 4039: 4034: 4029: 4024: 4019: 4015: 4011: 4007: 4000: 3998: 3983: 3979: 3973: 3969: 3959: 3956: 3954: 3951: 3950: 3946: 3935: 3932: 3926: 3921: 3914: 3912: 3900: 3895: 3892: 3889: 3886: 3879: 3874: 3871: 3869:40–450 pg/mL 3868: 3865: 3860: 3857: 3854: 3851: 3848: 3844: 3841: 3837: 3833: 3828: 3826: 3813: 3810: 3806: 3802: 3798: 3794: 3790: 3787: 3784: 3781: 3778: 3775: 3774: 3772: 3759: 3756: 3753: 3750: 3749: 3747: 3734: 3730: 3727: 3723: 3719: 3715: 3711: 3708: 3705: 3702: 3699: 3696: 3692: 3691: 3681: 3677: 3674: 3670: 3669: 3660: 3655: 3654: 3644: 3641: 3637: 3633: 3630: 3626: 3623: 3619: 3615: 3612: 3608: 3605: 3604:triglycerides 3601: 3597: 3593: 3589: 3585: 3583: 3578: 3575: 3574: 3563: 3561: 3557: 3553: 3549: 3545: 3540: 3536: 3534: 3530: 3525: 3522: 3521:psychological 3509: 3506: 3503: 3500: 3497: 3493: 3492: 3480: 3476: 3472: 3471: 3469: 3466: 3462: 3458: 3454: 3451: 3450: 3441: 3437: 3436:contraception 3433: 3430: 3427: 3423: 3419: 3416: 3413: 3409: 3405: 3401: 3397: 3396: 3395: 3388: 3384: 3380: 3376: 3373: 3368: 3365: 3361: 3357: 3353: 3352:Clitoromegaly 3350: 3346: 3343: 3342: 3332: 3328: 3325: 3322: 3318: 3315: 3314: 3313: 3302: 3298: 3294: 3290: 3288:will develop. 3287: 3283: 3280: 3276: 3272: 3271: 3262: 3258: 3255: 3252: 3249: 3248: 3234: 3231: 3228: 3227:growth plates 3224: 3222: 3218: 3215: 3212:Male-pattern 3211: 3208: 3205: 3204: 3200: 3199: 3195: 3192: 3191:triglycerides 3188: 3184: 3181: 3178: 3175: 3172: 3169: 3166: 3163: 3162: 3158: 3157: 3156: 3148: 3146: 3136: 3134: 3130: 3127: 3123: 3113: 3111: 3107: 3103: 3099: 3095: 3091: 3087: 3073: 3071: 3067: 3063: 3059: 3055: 3051: 3047: 3043: 3040:(AIs) (e.g., 3039: 3035: 3034:Antiestrogens 3029:Antiestrogens 3026: 3024: 3020: 3015: 3013: 3008: 3004: 2999: 2997: 2993: 2989: 2985: 2981: 2971: 2969: 2965: 2961: 2957: 2953: 2949: 2945: 2941: 2937: 2932: 2930: 2926: 2917: 2914: 2910: 2906: 2902: 2898: 2892: 2890: 2886: 2882: 2881:orally active 2878: 2874: 2870: 2866: 2865:17α-alkylated 2862: 2858: 2854: 2850: 2846: 2842: 2838: 2834: 2830: 2826: 2822: 2818: 2814: 2810: 2806: 2802: 2798: 2794: 2790: 2786: 2782: 2778: 2775: 2761: 2755: 2752:In 2003, the 2745: 2744:absorption). 2742: 2738: 2734: 2724: 2715: 2713: 2708: 2704: 2699: 2697: 2693: 2689: 2684: 2682: 2678: 2672: 2670: 2666: 2663:Testosterone 2653: 2649: 2645: 2643: 2639: 2638:trough levels 2634: 2630: 2626: 2623: 2619: 2615: 2610: 2606: 2602: 2598: 2588: 2585: 2583: 2579: 2575: 2571: 2567: 2561: 2559: 2545: 2536: 2530: 2528: 2520: 2514: 2512: 2502: 2500: 2498: 2496: 2494: 2492: 2490: 2488: 2486: 2484: 2476: 2470: 2466: 2462: 2458: 2455: 2453: 2452:5αR inhibitor 2450: 2447: 2445: 2441: 2437: 2434: 2432: 2426: 2423: 2421: 2417: 2413: 2410: 2407: 2404: 2402: 2398: 2394: 2391: 2388: 2385: 2384: 2380: 2377: 2374: 2371: 2370: 2366: 2363: 2360: 2357: 2355: 2351: 2347: 2344: 2342: 2339: 2336: 2334: 2330: 2326: 2323: 2321: 2318: 2315: 2313: 2309: 2305: 2302: 2300: 2297: 2294: 2292: 2288: 2281: 2278: 2275: 2272: 2270: 2266: 2254: 2251: 2248: 2245: 2243: 2239: 2235: 2232: 2229: 2226: 2224: 2220: 2211: 2208: 2205: 2202: 2200: 2196: 2187: 2181: 2178: 2175: 2173: 2169: 2162: 2157: 2154: 2151: 2150: 2147:30–120mg/day 2146: 2143: 2140: 2137: 2136: 2133:2.5–10mg/day 2132: 2129: 2126: 2123: 2122: 2119:25–100mg/day 2118: 2112: 2109: 2106: 2105: 2101: 2098: 2095: 2092: 2091: 2087: 2084: 2081: 2078: 2076: 2072: 2068: 2065: 2063: 2060: 2057: 2055: 2051: 2034: 2027: 2022: 2020: 2015: 2013: 2008: 2007: 2003: 2001: 1997: 1993: 1989: 1985: 1981: 1977: 1976:GnRH agonists 1973: 1969: 1965: 1961: 1957: 1953: 1949: 1945: 1935: 1929: 1926: 1922: 1918: 1915: 1911: 1910: 1909: 1903: 1899: 1895: 1891: 1887: 1883: 1879: 1875: 1871: 1867: 1863: 1859: 1856: 1852: 1848: 1847:Phenobarbital 1844: 1843: 1842: 1840: 1836: 1833: 1829: 1826: 1822: 1811: 1806: 1804: 1799: 1796: 1782: 1779: 1776: 1772: 1769: 1766: 1764: 1760: 1757: 1754: 1751: 1747: 1744: 1740: 1736: 1735:renal failure 1732: 1729: 1726: 1723: 1721: 1718: 1716: 1713: 1711: 1707: 1706: 1705: 1702: 1700: 1696: 1692: 1676: 1667: 1663: 1659: 1656: 1652: 1651: 1647: 1643: 1627: 1618: 1614: 1610: 1607: 1603: 1602: 1598: 1588: 1582: 1579: 1576: 1573: 1570: 1566: 1563: 1562: 1556: 1554: 1550: 1546: 1542: 1537: 1535: 1531: 1527: 1523: 1519: 1515: 1511: 1507: 1503: 1499: 1494: 1492: 1488: 1484: 1480: 1476: 1472: 1468: 1464: 1460: 1456: 1452: 1448: 1444: 1440: 1436: 1432: 1428: 1417: 1412: 1410: 1405: 1403: 1398: 1397: 1395: 1394: 1391: 1379: 1369: 1367: 1362: 1357: 1356: 1354: 1353: 1346: 1343: 1341: 1338: 1336: 1333: 1331: 1328: 1326: 1323: 1321: 1318: 1316: 1313: 1311: 1308: 1306: 1303: 1301: 1298: 1297: 1291: 1290: 1281: 1278: 1276: 1273: 1271: 1268: 1266: 1263: 1262: 1261: 1260:United States 1258: 1256: 1253: 1251: 1248: 1246: 1243: 1241: 1238: 1236: 1233: 1231: 1228: 1224: 1221: 1220: 1219: 1216: 1212: 1207: 1204: 1203: 1201: 1200: 1190: 1187: 1185: 1182: 1180: 1177: 1176: 1175: 1174:United States 1172: 1168: 1165: 1163: 1160: 1159: 1158: 1155: 1151: 1148: 1147: 1145: 1143: 1140: 1136: 1133: 1132: 1131:South Africa 1130: 1128: 1125: 1121: 1118: 1117: 1115: 1113: 1110: 1106: 1103: 1101: 1098: 1097: 1095: 1093: 1090: 1088: 1085: 1081: 1078: 1076: 1073: 1071: 1068: 1067: 1065: 1061: 1058: 1056: 1053: 1051: 1048: 1047: 1046: 1043: 1039: 1034: 1031: 1029: 1026: 1024: 1021: 1017: 1014: 1013: 1012: 1009: 1007: 1004: 1002: 999: 995: 992: 990: 987: 986: 985: 982: 981: 979: 973: 968: 967: 960: 959:Transmisogyny 957: 955: 952: 948: 945: 944: 943: 942:Transfeminism 940: 938: 935: 933: 930: 928: 927:Postgenderism 925: 923: 920: 918: 915: 913: 910: 907: 903: 901: 898: 895: 891: 889: 888:Gender binary 886: 884: 881: 879: 876: 874: 871: 869: 866: 864: 861: 859: 856: 853: 849: 848: 842: 841: 834: 831: 829: 826: 824: 821: 819: 816: 812: 809: 808: 807: 804: 802: 799: 797: 794: 792: 789: 787: 784: 782: 779: 778: 776: 769: 766: 764: 761: 759: 756: 754: 751: 749: 746: 744: 741: 739: 736: 735: 733: 724: 723: 716: 713: 709: 706: 704: 701: 700: 699: 696: 694: 691: 689: 686: 682: 681:Transmisogyny 679: 677: 674: 672: 669: 667: 664: 663: 662: 659: 655: 641: 640: 639: 636: 635: 629: 626: 624: 621: 620: 618: 616: 613: 609: 608:United States 606: 604: 601: 600: 599: 596: 594: 591: 589: 586: 585: 581: 578: 576: 575:Organizations 573: 571: 568: 567: 563: 560: 558: 555: 553: 550: 549: 546: 540: 539: 529: 525: 524: 523: 520: 517: 516:Voice therapy 513: 511: 508: 506: 503: 500: 496: 495: 490: 486: 483: 479: 474: 470: 467: 463: 462: 460: 456: 455: 450: 446: 442: 441:masculinizing 439: 437: 434: 433: 431: 427: 426: 421: 417: 412: 408: 407: 405: 401: 398: 397:Gender clinic 394: 393: 389: 384: 383: 376: 373: 369: 368: 364: 362: 359: 358: 357: 354: 350: 349: 345: 343: 342: 338: 336: 333: 332: 331: 328: 326: 323: 319: 316: 314: 313: 309: 307: 304: 302: 299: 297: 294: 292: 289: 287: 284: 282: 281: 277: 275: 272: 269: 268: 263: 261: 258: 256: 253: 252: 251: 248: 246: 243: 241: 240: 236: 232: 229: 228: 227: 224: 222: 219: 217: 216:Gender bender 214: 212: 209: 207: 206: 202: 200: 199: 195: 193: 190: 189: 186: 181: 180: 174: 171: 169: 166: 164: 161: 160: 158: 157: 139: 138: 135: 132: 131: 127: 123: 122: 113: 110: 102: 99:November 2016 91: 88: 84: 81: 77: 74: 70: 67: 63: 60: â€“  59: 55: 54:Find sources: 48: 44: 38: 37: 32:This article 30: 26: 21: 20: 9281: 9246:Progestogens 9161:testosterone 9142: 9069:enzalutamide 9065:bicalutamide 9046: 8988:Preparations 8947:Non-peptide: 8946: 8921: 8845: 8695:Mifepristone 8690:Aglepristone 8659:Telapristone 8594: 8588:Drospirenone 8584: 8573:Norgestimate 8548:Etonogestrel 8539: 8506:Norgesterone 8501:Noretynodrel 8457: 8454: 8434: 8431: 8425:Trimegestone 8420:Promegestone 8411: 8389: 8386: 8376: 8373:Medrogestone 8369: 8366:Proligestone 8272: 8269: 8254: 8248:Quingestrone 8243:Progesterone 8239: 8209:Progestogens 8197:Progestogens 8080: 8065: 8025:Progestogens 7928:testosterone 7888: 7873: 7867:Testolactone 7858: 7837: 7822: 7796:Ormeloxifene 7791:Mepitiostane 7786:Lasofoxifene 7781:Epitiostanol 7761:Broparestrol 7756:Bazedoxifene 7644:bicalutamide 7510: 7499:Quinestradol 7494:Promestriene 7288:noretynodrel 7269:metandienone 7257:testosterone 7239: 7088: 7048:Progestogens 6916:Ketoconazole 6844:5α-Reductase 6808:Ketoconazole 6798:Enzalutamide 6793:Darolutamide 6783:Bicalutamide 6774: 6738:Medrogestone 6733:Drospirenone 6696: 6589: 6539: 6529: 6499: 6488:Oxymetholone 6459: 6443:Oxymesterone 6379: 6353:Norclostebol 6330: 6304:Mepitiostane 6299:Epitiostanol 6275: 6227:Testosterone 6168: 5964: 5916:Testosterone 5880:Lou Sullivan 5830:. 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Retrieved 3981: 3972: 3911:bioidentical 3908: 3835: 3832:oophorectomy 3829: 3822: 3805:heart attack 3771:Polycythemia 3765:Polycythemia 3718:osteoporosis 3688:Bone changes 3580: 3541: 3537: 3526: 3518: 3461:oophorectomy 3457:hysterectomy 3392: 3377:The risk of 3372:oophorectomy 3311: 3293:5α-reductase 3268:Hair changes 3245:Skin changes 3154: 3142: 3122:menstruation 3119: 3116:Progestogens 3084: 3070:final height 3066:hip widening 3032: 3023:Tanner stage 3016: 3000: 2980:hypothalamus 2977: 2933: 2923: 2893: 2885:liver damage 2861:gynecomastia 2813:5α-reductase 2783:(AAS), like 2772: 2751: 2730: 2721: 2707:virilization 2700: 2685: 2673: 2662: 2635: 2631: 2627: 2594: 2586: 2562: 2555: 2552:Testosterone 2543: 2469: 2372:Depo-Provera 2260:500mg every 2255:250mg every 2246:Sustanon 250 2075:Testosterone 1990:to suppress 1972:feminization 1968:progesterone 1952:testosterone 1941: 1933: 1907: 1890:gynecomastia 1880:, and other 1874:itraconazole 1818: 1815:Interactions 1808: 1802: 1800: 1791: 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