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isolation, characterization and advanced development of antibodies targeting HIV, Ebola and COVID-19, the clinical evaluation of novel vaccine candidates and biologic products targeting respiratory syncytial virus (RSV), influenza, Malaria, and Zika, among others, and strategic collaboration with pharmaceutical and biotech partners advancing VRC products into effective public health interventions.
235:
In 2010, Dr. Mascola and colleagues discovered an antibody called VRC01 that potently neutralizes the HIV virus. Over the course of a decade, the VRC developed this and more potent antibodies to understand their potential to prevent and treat HIV infection. Investigators at the VRC also discovered an
222:
Mascola was appointed
Director of the VRC in 2013 and provided leadership to the scientific and clinical research activities of the Center, guiding development of vaccine and antibody-based research programs for diseases of high public health importance. Scientific advances and research include the
231:
Mascola’s laboratory research focused on rational design approaches to produce effective vaccine and antibody products to prevent and treat infectious diseases. His laboratory also studies how the immune system generates protective antibody responses against viruses and other infectious pathogens.
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in 1985. He completed a residency in internal medicine at the Naval
Medical Center, San Diego and a fellowship in infectious diseases at the National Naval Medical Center, Bethesda, MD, followed by a fellowship in retroviral diseases at the Walter Reed Army Institute of Research (WRAIR). Mascola
275:
Mascola helped establish and lead the
Operation Warp Speed Vaccine Development Team (VDT), responsible for coordinating the effort to develop and evaluate the COVID-19 vaccines selected within the US Government portfolio. He also serves as senior member on both NIH and HHS leadership teams that
194:
Mascola began his career in biomedical research as a U.S. Navy physician. Upon completion of his medical training, he served as a Staff
Research Physician in the Division of Retrovirology, WRAIR from 1993 – 2000. During this time, Mascola advanced multiple studies of HIV immunology and vaccine
506:"Tufts University - Jumbo Yearbook (Medford, MA), Class of 1981, Page 241 of 256 | E-Yearbook.com has the largest online yearbook collection of college, university, high school, middle school, junior high school, military, naval cruise books and yearbooks. Search and browse yearbooks online!"
320:
2021: NIH Director’s Award for
Outstanding Efforts in the Pursuit of Effective Vaccines and Therapeutics to COVID-19
1218:
Ruckwardt, Tracy J.; Morabito, Kaitlyn M.; Phung, Emily; Crank, Michelle C.; Costner, Pamela J.; Holman, LaSonji A.; Chang, Lauren A.; Hickman, Somia P.; Berkowitz, Nina M.; Gordon, Ingelise J.; Yamshchikov, Galina V. (2021-10-01).
1160:
Crank, Michelle C.; Ruckwardt, Tracy J.; Chen, Man; Morabito, Kaitlyn M.; Phung, Emily; Costner, Pamela J.; Holman, LaSonji A.; Hickman, Somia P.; Berkowitz, Nina M.; Gordon, Ingelise J.; Yamshchikov, Galina V. (2019-08-02).
1097:
Mulangu, Sabue; Dodd, Lori E.; Richard T. Davey, Jr; Mbaya, Olivier
Tshiani; Proschan, Michael; Mukadi, Daniel; Manzo, Mariano Lusakibanza; Nzolo, Didier; Oloma, Antoine Tshomba; Ibanda, Augustin; Ali, Rosine (2019-11-27).
236:
antibody against Ebola, and during the 2018 outbreak in the
Democratic Republic of Congo (DRC), this antibody, called mAb114, was shown to dramatically reduce mortality of Ebola virus disease. mAb114 has been developed by
1549:
Kanekiyo, Masaru; Joyce, M. Gordon; Gillespie, Rebecca A.; Gallagher, John R.; Andrews, Sarah F.; Yassine, Hadi M.; Wheatley, Adam K.; Fisher, Brian E.; Ambrozak, David R.; Creanga, Adrian; Leung, Kwanyee (March 2019).
1491:
Chen, Grace L.; Coates, Emily E.; Plummer, Sarah H.; Carter, Cristina A.; Berkowitz, Nina; Conan-Cibotti, Michelle; Cox, Josephine H.; Beck, Allison; O’Callahan, Mark; Andrews, Charla; Gordon, Ingelise J. (2020-04-14).
913:
Misasi, John; Gilman, Morgan S.A.; Kanekiyo, Masaru; Gui, Miao; Cagigi, Alberto; Mulangu, Sabue; Corti, Davide; Ledgerwood, Julie E.; Lanzavecchia, Antonio; Cunningham, James; Muyembe-Tamfun, Jean
Jacques (2016-03-18).
1036:
Gaudinski, Martin R.; Coates, Emily E.; Novik, Laura; Widge, Alicia; Houser, Katherine V.; Burch, Eugeania; Holman, LaSonji A.; Gordon, Ingelise J.; Chen, Grace L.; Carter, Cristina; Nason, Martha (2019-03-02).
157:
An internationally recognized expert on vaccine and antibody-based product development, Mascola has led biomedical research efforts targeting a wide breadth of viral pathogens for more than 30 years.
979:
Corti, Davide; Misasi, John; Mulangu, Sabue; Stanley, Daphne A.; Kanekiyo, Masaru; Wollen, Suzanne; Ploquin, Aurélie; Doria-Rose, Nicole A.; Staupe, Ryan P.; Bailey, Michael; Shi, Wei (2016-03-18).
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2014: Fellow, American
Academy of Microbiology (AAM)
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development. His research demonstrated the importance of neutralizing antibodies in protection against HIV and helped explain the reason that HIV vaccines have not yet been effective.
1221:"Safety, tolerability, and immunogenicity of the respiratory syncytial virus prefusion F subunit vaccine DS-Cav1: a phase 1, randomised, open-label, dose-escalation clinical trial"
414:
791:
Wu, Xueling; Zhou, Tongqing; Zhu, Jiang; Zhang, Baoshan; Georgiev, Ivelin; Wang, Charlene; Chen, Xuejun; Longo, Nancy S.; Louder, Mark; McKee, Krisha; O’Dell, Sijy (2011-09-16).
215:
Mascola joined the
Vaccine Research Center (VRC) in 2000 as a founding investigator and Principal Deputy Director. In this role, he worked with the Center’s founding director,
723:
Zhou, Tongqing; Georgiev, Ivelin; Wu, Xueling; Yang, Zhi-Yong; Dai, Kaifan; Finzi, Andrés; Kwon, Young Do; Scheid, Johannes; Shi, Wei; Xu, Ling; Yang, Yongping (2010-08-13).
240:
and licensed for use by the FDA. Other major vaccines and antibodies under development include those for RSV, chikungunya virus and improved vaccines for Influenza.
856:
Corey, L.; Gilbert, P.B.; Juraska, M.; Montefiori, D.C.; Morris, L.; Karuna, S.T.; Edupuganti, S.; Mgodi, N.M.; deCamp, A.C.; Rudnicki, E.; Huang, Y. (2021-03-18).
2056:
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1039:"Safety, Tolerability, Pharmacokinetics, and Immunogenicity of mAb114: A Phase 1 Trial of a Therapeutic Monoclonal Antibody Targeting Ebola Virus Glycoprotein"
529:
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288:(ASCI)
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1300:
154:, director of NIAID, on vaccines and biomedical research affairs. Mascola is the current Chief Scientific Officer for ModeX Therapeutics.
1277:"NIH Begins First-in-Human Trial of a Universal Influenza Vaccine Candidate | NIH: National Institute of Allergy and Infectious Diseases"
285:
219:, to build a broad research portfolio, including the capacity of the Center to develop and evaluate new vaccines and antibody products.
1399:
365:
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1400:"Phase 2 Zika Vaccine Trial Begins in U.S., Central and South America | NIH: National Institute of Allergy and Infectious Diseases"
1301:"NIH Launches Clinical Trial of Universal Influenza Vaccine Candidate | NIH: National Institute of Allergy and Infectious Diseases"
695:
177:
1326:"First Human Trial of Monoclonal Antibody to Prevent Malaria Opens | NIH: National Institute of Allergy and Infectious Diseases"
472:
415:"Inside the quixotic 30-year quest that gave us the Covid-19 treatments, vaccines and could unlock vaccinology's new holy grail"
1375:
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1666:"FDA Takes Additional Action in Fight Against COVID-19 By Issuing Emergency Use Authorization for Second COVID-19 Vaccine"
505:
1376:"NIH Begins Testing Investigational Zika Vaccine in Humans | NIH: National Institute of Allergy and Infectious Diseases"
1473:
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1494:"Effect of a Chikungunya Virus–Like Particle Vaccine on Safety and Tolerability Outcomes: A Randomized Clinical Trial"
1351:"Monoclonal Antibody Prevents Malaria in Small NIH Trial | NIH: National Institute of Allergy and Infectious Diseases"
2036:
1631:
LaFraniere, Sharon; Thomas, Katie; Weiland, Noah; Gelles, David; Stolberg, Sheryl Gay; Grady, Denise (2020-11-21).
1869:
1690:"Lilly Begins World's First Study of a Potential COVID-19 Antibody Treatment in Humans | Eli Lilly and Company"
276:
provided recommendations on COVID-19 variants of concern, vaccine boosters and heterologous vaccine platforms.
138:
is an American physician-scientist, immunologist and infectious disease specialist. He was the director of the
203:
164:
facilitating the rapid development, evaluation, and subsequent authorization of effective COVID-19 vaccines.
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As part of the United States Government COVID-19 Response, Mascola led the Vaccine Development Team (VDT) of
147:
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1966:
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1748:"Lilly's bebtelovimab receives Emergency Use Authorization for the treatment of mild-to-moderate COVID-19"
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1552:"Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses"
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981:"Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody"
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115:
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17:
2026:
793:"Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing"
640:"Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning"
1778:
916:"Structural and Molecular Basis for Ebola Virus Neutralization by Protective Human Antibodies"
265:
1991:
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authorized for use in November 2020 and bebtelovimab authorized for use in February 2022.
8:
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Corey, Lawrence; Mascola, John R.; Fauci, Anthony S.; Collins, Francis S. (2020-05-29).
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725:"Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01"
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342:"John Mascola, M.D. | NIH: National Institute of Allergy and Infectious Diseases"
1608:"NIH Vaccine Research Center Leads the Way to Safe, Effective COVID-19 Vaccines"
1163:"A proof of concept for structure-based vaccine design targeting RSV in humans"
858:"Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition"
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in 1981 with a Bachelor of Science degree and earned his medical degree from
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completed board-certification in internal medicine and infectious diseases.
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442:"Meet the Researcher Leading NIH's COVID-19 Vaccine Development Efforts"
216:
93:
41:
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Mascola, John R.; Graham, Barney S.; Fauci, Anthony S. (2021-04-06).
1633:"Politics, Science and the Remarkable Race for a Coronavirus Vaccine"
261:
1100:"A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics"
656:
639:
638:
Kwong, Peter D.; Mascola, John R.; Nabel, Gary J. (September 2013).
226:
473:"The NIH's Top Vaccine Maker Wants Warp Speed to Be the New Normal"
97:
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Washingtonians of the Year
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855:
1894:"79 Fellows elected to the American Academy of Microbiology"
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to design and develop a successful mRNA vaccine that became
1217:
696:"NIAID selects new director of the Vaccine Research Center"
366:"NIAID Selects New Director of the Vaccine Research Center"
1917:
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1422:
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Research, Center for Drug Evaluation and (2021-09-30).
912:
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150:(NIH). He also served as a principal advisor to
260:, authorized for use (EUA) in December 2020 and with
144:
National Institute of Allergy and Infectious Diseases
112:
National Institute of Allergy and Infectious Diseases
1942:"National Academy of Medicine Elects 80 New Members"
1794:"SARS-CoV-2 Viral Variants—Tackling a Moving Target"
1791:
1425:"A strategic approach to COVID-19 vaccine R&D"
722:
1850:"The American Society for Clinical Investigation"
637:
590:
227:Novel Vaccine and Antibody-Based Product Research
2013:
2057:Fellows of the American Academy of Microbiology
2032:Georgetown University School of Medicine alumni
591:Mascola, John R.; Montefiori, David C. (2010).
503:
391:"Top vaccine researcher to speak at CTSI Forum"
790:
268:to isolate a SARS-CoV-2 monoclonal antibodies
1663:
189:
2052:Members of the National Academy of Medicine
1992:"2021 NIAID Awards | NIH Director's Awards"
530:"Medical Alumni Board June 2018 Newsletter"
286:American Society for Clinical Investigation
1967:"Meet Our 2020 Washingtonians of the Year"
1664:Commissioner, Office of the (2020-12-21).
40:
2042:United States Navy Medical Corps officers
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252:led the partnerships between the VRC and
1474:"FDA approves treatment for ebola virus"
1471:
593:"The role of antibodies in HIV vaccines"
202:
178:Georgetown University School of Medicine
243:
57:Director of the Vaccine Research Center
14:
2022:American infectious disease physicians
2014:
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609:10.1146/annurev-immunol-030409-101256
2047:National Institutes of Health people
1870:"Association of American Physicians"
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336:
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1715:"May I Borrow Your Covid Immunity?"
862:The New England Journal of Medicine
700:National Institutes of Health (NIH)
199:Leading the Vaccine Research Center
24:
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1087:
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293:Association of American Physicians
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1055:10.1016/S0140-6736(19)30036-4
324:
148:National Institutes of Health
108:National Institutes of Health
1946:National Academy of Medicine
1922:National Academy of Medicine
570:10.1097/COH.0b013e3283304ea1
303:National Academy of Medicine
167:
27:American Physician-Scientist
7:
597:Annual Review of Immunology
534:myemail.constantcontact.com
10:
2073:
1996:directorsawards.hr.nih.gov
564:(5): vii. September 2009.
248:Mascola and his colleague
1568:10.1038/s41590-018-0305-x
644:Nature Reviews Immunology
554:"Editorial introductions"
238:Ridgeback Biotherapeutics
207:Mascola greets President
190:Early Biomedical Research
184:
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55:
51:
39:
32:
1746:Company, Eli Lilly and.
270:Ly-CoV555 (bamlanivimab)
2037:Tufts University alumni
1442:10.1126/science.abc5312
1188:10.1126/science.aav9033
1006:10.1126/science.aad5224
940:10.1126/science.aad6117
817:10.1126/science.1207532
749:10.1126/science.1192819
172:Mascola graduated from
140:Vaccine Research Center
116:Vaccine Research Center
1811:10.1001/jama.2021.2088
1510:10.1001/jama.2020.2477
315:Washingtonian Magazine
280:Professional societies
212:
1612:NIH COVID-19 Research
1117:10.1056/NEJMoa1910993
874:10.1056/NEJMoa2031738
504:e-yearbook.com (tm).
206:
46:John R. Mascola, M.D.
244:Response to COVID-19
162:Operation Warp Speed
1179:2019Sci...365..505C
997:2016Sci...351.1339C
991:(6279): 1339–1342.
932:2016Sci...351.1343M
926:(6279): 1343–1346.
809:2011Sci...333.1593W
803:(6049): 1593–1602.
741:2010Sci...329..811Z
446:NIH Director's Blog
142:(VRC), part of the
67:Julie E. Ledgerwood
1777:has generic name (
1767:cite press release
1752:www.prnewswire.com
1694:investor.lilly.com
1637:The New York Times
1049:(10174): 889–898.
213:
1804:(13): 1261–1262.
1713:Khamsi, Roxanne.
1556:Nature Immunology
1504:(14): 1369–1377.
1435:(6494): 948–950.
1404:www.niaid.nih.gov
1380:www.niaid.nih.gov
1355:www.niaid.nih.gov
1332:. 27 January 2020
1330:www.niaid.nih.gov
1305:www.niaid.nih.gov
1281:www.niaid.nih.gov
1231:(10): 1111–1120.
1173:(6452): 505–509.
1110:(24): 2293–2303.
868:(11): 1003–1014.
735:(5993): 811–817.
370:Global Biodefense
346:www.niaid.nih.gov
133:
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84:Scientific career
16:(Redirected from
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1357:. 11 August 2021
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309:Selected awards
301:2017: Elected,
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136:John R. Mascola
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70:Richard A. Koup
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34:John R. Mascola
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