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Malabsorption

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1241: 361:. Impaired calcium and vitamin D absorption and chelation of calcium by unabsorbed fatty acids resulting in fecal loss of calcium may all contribute. If calcium deficiency is prolonged, secondary hyperparathyroidism may develop. Prolonged malnutrition may induce amenorrhea, infertility, and impotence. Edema and even ascites may reflect hypoproteinemia associated with protein losing enteropathy caused by 316:. Malabsorption of dietary nutrients and excessive fluid secretion by inflamed small intestine also contribute to abdominal distention and bloating. Prevalence, severity, and character of abdominal pain vary considerably among the various disease processes associated with intestinal malabsorption. For example, pain is common in patients with chronic pancreatitis or pancreatic cancer and 34: 290:, and pain may be present. Although diarrhea is a common complaint, the character and frequency of stools may vary considerably ranging from over 10 watery stools per day to less than one voluminous putty-like stool, the latter causing some patients to complain of constipation. On the other hand, stool mass is invariably increased in patients with 304:
nutrients by significantly increasing their oral intake. Eliciting a careful dietary history from patients with suspected malabsorption is therefore crucial. Excessive flatus and abdominal bloating may reflect excessive gas production due to fermentation of unabsorbed carbohydrate, especially among patients with a primary or secondary
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Substantial numbers of patients with intestinal malabsorption present initially with symptoms or laboratory abnormalities that point to other organ systems in the absence of or overshadowing symptoms referable to the gastrointestinal tract. For example, there is increasing epidemiologic evidence that
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and signs. A range of different conditions can produce malabsorption and it is necessary to look for each of these specifically. Many tests have been advocated, and some, such as tests for pancreatic function are complex, vary between centers and have not been widely adopted. However, better tests
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both impair absorption and induce secretion of water and electrolytes by the colon adding to stool mass. Weight loss is common among patients with significant intestinal malabsorption but must be evaluated in the context of caloric intake. Some patients compensate for fecal wastage of unabsorbed
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secretions add an additional 7–8 L of protein-, lipid-, and electrolyte-containing fluid to intestinal contents. This massive load is reduced by the small and large intestines to less than 200 g of stool that contains less than 8 g of fat, 1–2 g of nitrogen, and less than 20 mmol each of
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Normally the human gastrointestinal tract digests and absorbs dietary nutrients with remarkable efficiency. A typical Western diet ingested by an adult in one day includes approximately 100 g of fat, 400 g of carbohydrate, 100 g of protein, 2 L of fluid, and the required
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have become available with greater ease of use, better sensitivity and specificity for the causative conditions. Tests are also needed to detect the systemic effects of deficiency of the malabsorbed nutrients (such as anaemia with vitamin B12 malabsorption).
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and generalized malabsorption above the normal with 150–200 g/day. Not only do unabsorbed nutrients contribute to stool mass but mucosal fluid and electrolyte secretion is also increased in diseases associated with mucosal inflammation such as
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Depending on the nature of the disease process causing malabsorption and its extent, gastrointestinal symptoms may range from severe to subtle or may even be totally absent.
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or extensive mucosal inflammation. Dermatitis and peripheral neuropathy may be caused by malabsorption of specific vitamins or micronutrients and essential fatty acids.
1661: 396:, is the most common feature. Watery, diurnal and nocturnal, bulky, frequent stools are the clinical hallmark of overt malabsorption. It is due to impaired water, 245:, or if the disease process is limited to the very proximal small intestine, then selective malabsorption of only a single nutrient may occur. However, generalized 2141: 947:
is initiated by intraluminal processes requiring gastric, pancreatic, and biliary secretions. The final products of digestion are absorbed through the
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of multiple dietary nutrients develops when the disease process is extensive, thus disturbing several digestive and absorptive processes, as occurs in
2645: 357:, or even frank bleeding may reflect hypoprothrombinemia secondary to vitamin K malabsorption. Osteopenia is common, especially in the presence of 1880:
Bertomeu A, Ros E, BarragĂĄn V, Sachje L, Navarro S (1991). "Chronic diarrhea with normal stool and colonic examinations: organic or functional?".
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absorption or both. Low cholesterol or triglyceride may give a clue toward fat malabsorption. Low calcium and phosphate may give a clue toward
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Thomas P, Forbes A, Green J, Howdle P, Long R, Playford R, Sheridan M, Stevens R, Valori R, Walters J, Addison G, Hill P, Brydon G (2003).
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and fluid may be necessary. In severe deficiency, hospital admission may be required for nutritional support and detailed advice from
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If there is impairment of any of the many steps involved in the complex process of nutrient digestion and absorption, intestinal
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Symptoms can manifest in a variety of ways and features might give a clue to the underlying condition. Symptoms can be
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There is no single, specific test for malabsorption. As for most medical conditions, investigation is guided by
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presenting as fatigue and weakness, and the first of which can give rise to neuropsychiatric symptoms such as
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CT abdomen is useful in ruling out structural abnormality, done in pancreatic protocol when visualising
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levels can be checked. Fat soluble vitamins (A, D, E and K) are affected in fat malabsorption. Prolonged
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Fine KD, Schiller LR (1999). "technical review on the evaluation and management of chronic diarrhea".
958:(intraluminal process), absorption (mucosal process) and transport (postmucosal events) of nutrients. 2951: 2907: 2860: 2666: 2284: 988: 565: 3297: 2977: 2612: 2570: 2383: 2258: 2245: 2215: 2186: 2056: 149:. Impairment can be of single or multiple nutrients depending on the abnormality. This may lead to 1437:
may be able to provide sufficient nutritional supplementation. Tube placement may also be done by
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Malabsorption constitutes the pathological interference with the normal physiological sequence of
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absorption test for mucosal disease or bacterial overgrowth. Normal in pancreatic insufficiency.
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may ensue. If the abnormality involves a single step in the absorptive process, as in primary
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and abdominal discomfort. Cramping pain usually suggests obstructive intestinal segment
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Serological studies. Specific tests are carried out to determine the underlying cause.
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Some prefer to classify malabsorption clinically into three basic categories:
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in the absence of significant classic gastrointestinal symptoms. Microcytic,
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Abnormality in absorption of food nutrients across the gastrointestinal tract
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Walker-Smith J, Barnard J, Bhutta Z, Heubi J, Reeves Z, Schmitz J (2002).
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Weight loss can be significant despite increased oral intake of nutrients.
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Gasbarrini G, Frisono M: Critical evaluation of malabsorption tests; in
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Microscopy is particularly useful in diarrhoea, may show protozoa like
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or extra-intestinal - the former predominates in severe malabsorption.
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Treatment is directed largely towards management of underlying cause:
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Read N, Krejs G, Read M, Santa Ana C, Morawski S, Fordtran J (1980).
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include chewing, gastric churning, and the to-and-fro mixing in the
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will show pancreatic and biliary structural abnormalities.
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Dietary modification is important in some conditions:
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are supplemented orally in pancreatic insufficiency.
1433:. Use of enteral nutrition by naso-gastric or other 1814:Dobrilla G, Bertaccini G (1986). Langman G (ed.). 1813: 265: 323: 3421: 714:(constitutional, secondary or rarely congenital) 329:more patients with coeliac disease present with 430:Growth retardation, failure to thrive, delayed 377:Small intestine : major site of absorption 1816:Problems and Controversies in Gastroenterology 1681: 758:Terminal ileal disease such as Crohn's disease 2135: 1227:(MRCP) to complement or as an alternative to 424:, especially if it persists after defecation. 2241:Esophagogastric junction outflow obstruction 1564: 1706: 1225:Magnetic resonance cholangiopancreatography 1178:is indicative of pancreatic insufficiency. 971:or acquired reduction in absorptive surface 341:, or dimorphic anemia may reflect impaired 2280:Esophageal intramural pseudodiverticulosis 2142: 2128: 1838: 1832: 1398:breath test (C-glycocholate) to determine 1326:is necessary in colonic and ileal disease. 32: 1982: 1956: 1954: 1952: 1932: 1856: 1781: 1740: 1613:Bai J (1998). "Malabsorption syndromes". 1538: 1536: 1534: 1532: 1530: 1235: 1182:and pancreolauryl can be assessed as well 404:absorption or irritation from unabsorbed 1818:. New York: Raven Pr. pp. 123–130. 1384:Obsolete tests no longer used clinically 1239: 372: 1608: 1606: 1604: 1336: 1186: 1161:, ova, cyst and other infective agents. 822:Common variable immunodeficiency (CVID) 663:Bariatric surgery (Weight loss surgery) 137:is a state arising from abnormality in 120:; genetic diseases; certain medications 3422: 1949: 1527: 3264: 2508:Small intestinal bacterial overgrowth 2123: 1612: 1495:will help with reducing diarrhoea in 720:Intestinal enteropeptidase deficiency 260: 114:small intestinal bacterial overgrowth 1917:"Chronic diarrhea of unknown origin" 1686:. Edinburgh: Churchill Livingstone. 1601: 1086:usually implies iron deficiency and 717:Intestinal disaccharidase deficiency 1713:Therapeutic Advances in Drug Safety 1439:percutaneous endoscopic gastrostomy 631:Inflammatory bowel diseases, as in 13: 1684:Malabsorption in clinical practice 886: 658:Due to surgical structural changes 253:with extensive involvement of the 14: 3451: 3393:Spontaneous bacterial peritonitis 3240:Exocrine pancreatic insufficiency 2003: 1356:Glucose hydrogen breath test for 1020: 878:Chronic Proton Pump Inhibitor Use 473:, and decreased mental abilities. 110:exocrine pancreatic insufficiency 3430:Gastrointestinal tract disorders 3138:Secondary sclerosing cholangitis 1894:10.1097/00004836-199110000-00011 1783:10.1097/00005176-200208002-00006 1151: 1133:Anti-transglutaminase antibodies 617:Infiltrative conditions such as 2379:Gastric antral vascular ectasia 2374:Portal hypertensive gastropathy 2251:Gastroesophageal reflux disease 1908: 1873: 1770:J. Pediatr. Gastroenterol. Nutr 1316:is able to visualise the whole 368: 266:Gastrointestinal manifestations 3133:Primary sclerosing cholangitis 2983:Hepatic veno-occlusive disease 2805:Solitary rectal ulcer syndrome 1806: 1757: 1700: 1675: 1649: 1558: 1060: 650:and collagen vascular diseases 324:Extraintestinal manifestations 44:: Alcian blue with apparently 1: 3190:Sphincter of Oddi dysfunction 1969:. 52 Suppl 5 (90005): v1–15. 1579:10.1016/s0016-5085(99)70513-5 1520: 1481:therapy to treat Small Bowel 1416: 1292:, abetalipoproteinaemia etc.) 1171:is rarely performed nowadays. 1052:, as in exceptional cases of 964:malabsorption can be due to: 931:involves both mechanical and 408:. The latter also results in 3435:Steatorrhea-related diseases 3099:Postcholecystectomy syndrome 2618:Intestinal pseudoobstruction 2226:Esophageal motility disorder 1934:10.1016/0016-5085(80)90575-2 1707:Heidelbaugh JJ (June 2013). 1145:gluten sensitive enteropathy 1007: 763:Pancreatic insufficiencies: 710:Lactase deficiency inducing 627:eosinophilic gastroenteritis 7: 1503: 1320:and is occasionally useful. 147:gastrointestinal (GI) tract 10: 3456: 3084:Gallstone / Cholelithiasis 2608:Functional colonic disease 2404:Zollinger–Ellison syndrome 1515:Protein losing enteropathy 1447:total parenteral nutrition 1425:Replacement of nutrients, 1351:primary bile acid diarrhea 1252:manifested by blunting of 1137:Anti-endomysial antibodies 1090:can be caused by impaired 784:Zollinger-Ellison syndrome 754:Primary bile acid diarrhea 706:Due to enzyme deficiencies 681:Due to mucosal abnormality 355:subconjunctival hemorrhage 3378: 3257: 3198: 3112: 3069: 2915: 2906: 2859: 2813: 2768: 2654: 2541: 2431: 2418: 2293: 2285:Acute esophageal necrosis 2167: 2158: 2082: 2011: 1975:10.1136/gut.52.suppl_5.v1 1365:hydrogen breath test for 1206:may be undertaken to see 1195:is useful in delineating 989:enterohepatic circulation 595:Due to structural defects 510: 498:Bleeding tendencies from 488:absorption. Also lead to 124: 93: 69: 59: 40: 31: 26: 2384:Gastric dumping syndrome 2259:Laryngopharyngeal reflux 2246:Diffuse esophageal spasm 1725:10.1177/2042098613482484 1658:"Malabsorption syndrome" 1544:"Malabsorption Syndrome" 1276:pathology and obtain D2 891:The main purpose of the 733:Due to digestive failure 3000:Alcoholic liver disease 2533:Bile acid malabsorption 2477:Peptic (duodenal) ulcer 1845:J Gastroenterol Hepatol 1682:Losowsky, M.S. (1974). 1497:bile acid malabsorption 1408:to establish cause of B 1377:intestinal permeability 1347:bile acid malabsorption 1264:infiltration of crypts. 1105:Specific vitamins like 739:Bile salt malabsorption 519:Due to infective agents 181:, and other elements. 3010:Hepatic encephalopathy 2394:Buried bumper syndrome 2325:Peptic (gastric) ulcer 2209:Mallory–Weiss syndrome 2152:human digestive system 1882:J. Clin. Gastroenterol 1510:Fructose malabsorption 1493:bile acid sequestrants 1265: 1236:Interventional studies 893:gastrointestinal tract 694:Fructose malabsorption 690:Cows' milk intolerance 378: 48:counterstain enlarged 3235:Pancreatic pseudocyst 3104:Porcelain gallbladder 2216:Zenker's diverticulum 1469:Lactose avoidance in 1243: 1193:Barium follow through 1174:Low fecal pancreatic 1044:abetalipoproteinaemia 1034:lactose malabsorption 949:intestinal epithelial 874:Other Possible Causes 802:Abetalipoproteinaemia 767:Carcinoma of pancreas 698:Soya milk intolerance 563:Ancylostoma duodenale 526:related malabsorption 376: 363:lymphatic obstruction 3039:Hepatorenal syndrome 2978:Budd–Chiari syndrome 2935:Autoimmune hepatitis 2760:Intestinal adhesions 2518:Short bowel syndrome 2347:Functional dyspepsia 2265:Esophageal stricture 2231:Nutcracker esophagus 1776:(Suppl 2): S98–105. 1483:Bacterial overgrowth 1462:Gluten-free diet in 1358:bacterial overgrowth 1349:in ileal disease or 1337:Other investigations 1298:for enteropathy and 1187:Radiological studies 981:Defects of specific 945:Enzymatic hydrolysis 937:Mechanical processes 772:Chronic pancreatitis 749:Obstructive jaundice 744:Bacterial overgrowth 643:Short bowel syndrome 545:(fish tape worm) (B 308:deficiency, such as 102:short bowel syndrome 3178:Choledocholithiasis 3049:Metabolic disorders 3015:Acute liver failure 2988:Portal hypertension 2940:Alcoholic hepatitis 2783:Radiation proctitis 2702:Mesenteric ischemia 2674:Gastroenterocolitis 2503:Blind loop syndrome 2313:MĂ©nĂ©trier's disease 2221:Barrett's esophagus 1839:Newnham ED (2017). 1471:lactose intolerance 1371:Sugar probes or Cr- 1367:lactose intolerance 1102:from low vitamin D. 935:breakdown of food. 858:Hyperparathyroidism 724:Sucrose intolerance 712:lactose intolerance 638:Radiation enteritis 576:Traveler's diarrhea 467:abnormal sensations 314:sucrose intolerance 310:lactose intolerance 3353:Undefined location 3344:Grynfeltt–Lesshaft 3245:Pancreatic fistula 3228:Pancreatic abscess 3183:Biliary dyskinesia 3154:Mirizzi's syndrome 2655:Large and/or small 2335:Dieulafoy's lesion 2204:Boerhaave syndrome 2083:External resources 1851:(Suppl 1): 82–85. 1266: 1084:microcytic anaemia 915:, micronutrients ( 862:Hypoparathyroidism 812:Carcinoid syndrome 797:affecting GI tract 648:Systemic sclerosis 570:Necator americanus 504:coagulation factor 471:difficulty walking 379: 261:Signs and symptoms 243:lactase deficiency 106:lactase deficiency 3417: 3416: 3413: 3412: 3253: 3252: 2855: 2854: 2712:Bowel obstruction 2414: 2413: 2117: 2116: 1858:10.1111/jgh.13704 1627:10.1159/000007529 1345:test to diagnose 1314:Capsule Endoscopy 1290:Whipple's disease 1121:can be caused by 1042:, as observed in 884: 883: 853:Diabetes mellitus 830:Pernicious anemia 807:Addison's disease 795:systemic diseases 586:Whipple's disease 153:and a variety of 132: 131: 118:Whipple's disease 42:Whipple's disease 21:Medical condition 3447: 3405:Pneumoperitoneum 3262: 3261: 3172:Common bile duct 3054:Wilson's disease 3044:Peliosis hepatis 2913: 2912: 2790:Proctalgia fugax 2697:Abdominal angina 2622:Ogilvie syndrome 2571:Pseudomembranous 2429: 2428: 2389:Gastric volvulus 2354:Pyloric stenosis 2165: 2164: 2150:Diseases of the 2144: 2137: 2130: 2121: 2120: 2009: 2008: 1997: 1996: 1986: 1958: 1947: 1946: 1936: 1921:Gastroenterology 1912: 1906: 1905: 1877: 1871: 1870: 1860: 1836: 1830: 1829: 1810: 1804: 1803: 1785: 1761: 1755: 1754: 1744: 1704: 1698: 1697: 1679: 1673: 1672: 1670: 1669: 1660:. Archived from 1653: 1647: 1646: 1610: 1599: 1598: 1573:(6): 1464–1486. 1567:Gastroenterology 1562: 1556: 1555: 1553: 1551: 1540: 1197:small intestinal 1119:prothrombin time 993:Mucosal damage ( 834:intrinsic factor 826:Fiber Deficiency 549:malabsorption), 543:diphyllobothrium 515: 514: 450:, commonly from 233: 229: 225: 224: 223: 220: 213: 209: 205: 128:Depends on cause 65:Gastroenterology 36: 24: 23: 3455: 3454: 3450: 3449: 3448: 3446: 3445: 3444: 3420: 3419: 3418: 3409: 3374: 3363:Internal hernia 3249: 3194: 3159:Biliary fistula 3117: 3108: 3094:Adenomyomatosis 3089:Cholesterolosis 3065: 3059:Hemochromatosis 2930:Viral hepatitis 2902: 2851: 2809: 2795:Rectal prolapse 2764: 2731:Fecal impaction 2721:Intussusception 2684:Crohn's disease 2650: 2633:Toxic megacolon 2545: 2543:Large intestine 2537: 2482:Curling's ulcer 2435: 2433:Small intestine 2422: 2410: 2318:Gastroenteritis 2289: 2154: 2148: 2118: 2113: 2112: 2078: 2077: 2020: 2006: 2001: 2000: 1959: 1950: 1913: 1909: 1878: 1874: 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3341: 3328: 3327: 3322: 3317: 3312: 3307: 3306: 3305: 3300: 3289: 3288: 3283: 3282: 3281: 3270: 3268: 3259: 3255: 3254: 3251: 3250: 3248: 3247: 3242: 3237: 3232: 3231: 3230: 3225: 3220: 3215: 3204: 3202: 3196: 3195: 3193: 3192: 3187: 3186: 3185: 3180: 3167: 3166: 3161: 3156: 3147: 3146: 3145: 3140: 3135: 3124: 3122: 3110: 3109: 3107: 3106: 3101: 3096: 3091: 3086: 3081: 3075: 3073: 3067: 3066: 3064: 3063: 3062: 3061: 3056: 3046: 3041: 3036: 3035: 3034: 3029: 3019: 3018: 3017: 3012: 3002: 2997: 2996: 2995: 2990: 2985: 2980: 2968: 2967: 2966: 2956: 2955: 2954: 2944: 2943: 2942: 2937: 2932: 2921: 2919: 2910: 2904: 2903: 2901: 2900: 2899: 2898: 2888: 2887: 2886: 2881: 2871: 2869:Blood in stool 2865: 2863: 2857: 2856: 2853: 2852: 2850: 2849: 2844: 2842:Anal dysplasia 2839: 2834: 2829: 2819: 2817: 2811: 2810: 2808: 2807: 2802: 2797: 2792: 2787: 2786: 2785: 2774: 2772: 2766: 2765: 2763: 2762: 2757: 2756: 2755: 2745: 2744: 2743: 2733: 2728: 2723: 2718: 2709: 2707:Angiodysplasia 2704: 2699: 2688: 2687: 2686: 2676: 2671: 2670: 2669: 2658: 2656: 2652: 2651: 2649: 2648: 2642:Diverticulosis 2638:Diverticulitis 2635: 2626: 2625: 2624: 2615: 2605: 2600: 2599: 2598: 2593: 2588: 2583: 2578: 2573: 2563: 2557: 2555: 2539: 2538: 2536: 2535: 2530: 2528:Milroy disease 2525: 2520: 2515: 2510: 2505: 2500: 2498:Tropical sprue 2495: 2486: 2485: 2484: 2474: 2473: 2472: 2467: 2462: 2451: 2449: 2426: 2420:Lower GI tract 2416: 2415: 2412: 2411: 2409: 2408: 2407: 2406: 2396: 2391: 2386: 2381: 2376: 2371: 2366: 2361: 2356: 2351: 2350: 2349: 2339: 2338: 2337: 2332: 2322: 2321: 2320: 2315: 2310: 2299: 2297: 2291: 2290: 2288: 2287: 2282: 2277: 2272: 2267: 2262: 2256: 2255: 2254: 2248: 2243: 2238: 2233: 2223: 2218: 2213: 2212: 2211: 2206: 2196: 2195: 2194: 2189: 2184: 2173: 2171: 2162: 2160:Upper GI tract 2156: 2155: 2147: 2146: 2139: 2132: 2124: 2115: 2114: 2111: 2110: 2099: 2087: 2086: 2084: 2080: 2079: 2076: 2075: 2064: 2053: 2038: 2021: 2016: 2015: 2013: 2012:Classification 2005: 2004:External links 2002: 1999: 1998: 1948: 1907: 1872: 1831: 1824: 1805: 1756: 1719:(3): 125–133. 1699: 1692: 1674: 1648: 1600: 1557: 1525: 1524: 1522: 1519: 1518: 1517: 1512: 1505: 1502: 1501: 1500: 1489:Cholestyramine 1486: 1476: 1475: 1474: 1467: 1457: 1450: 1449:may be needed. 1441:, or surgical 1418: 1415: 1414: 1413: 1409: 1406:Schilling test 1403: 1402:malabsorption. 1393: 1385: 1382: 1381: 1380: 1369: 1360: 1354: 1338: 1335: 1334: 1333: 1327: 1321: 1311: 1293: 1286:tropical sprue 1237: 1234: 1233: 1232: 1222: 1215: 1188: 1185: 1184: 1183: 1172: 1162: 1153: 1150: 1149: 1148: 1126: 1103: 1062: 1059: 1058: 1057: 1047: 1037: 1022: 1021:Classification 1019: 1009: 1006: 1005: 1004: 998: 991: 985: 979: 972: 923:), water, and 921:trace minerals 888: 885: 882: 881: 880: 879: 870: 869: 868: 867: 864: 855: 850: 844:Hypothyroidism 841: 840:malabsorption) 837: 827: 824: 819: 814: 809: 804: 789: 788: 787: 786: 781: 780: 779: 774: 769: 761: 760: 759: 756: 751: 746: 729: 728: 727: 726: 721: 718: 715: 702: 701: 700: 699: 696: 691: 688: 677: 676: 675: 674: 665: 654: 653: 652: 651: 645: 640: 635: 629: 615: 602: 591: 590: 589: 588: 583: 581:Tropical sprue 578: 573: 546: 533: 527: 512: 509: 508: 507: 496: 474: 453: 445: 435: 428: 425: 370: 367: 325: 322: 306:disaccharidase 267: 264: 262: 259: 143:food nutrients 130: 129: 126: 122: 121: 95: 91: 90: 73: 67: 66: 63: 57: 56: 38: 37: 29: 28: 20: 15: 9: 6: 4: 3: 2: 3452: 3441: 3438: 3436: 3433: 3431: 3428: 3427: 3425: 3406: 3403: 3401: 3398: 3394: 3391: 3390: 3389: 3386: 3385: 3383: 3381: 3377: 3369: 3366: 3364: 3361: 3359: 3356: 3355: 3354: 3351: 3350: 3345: 3342: 3340: 3337: 3336: 3335: 3334: 3330: 3329: 3326: 3323: 3321: 3318: 3316: 3313: 3311: 3308: 3304: 3301: 3299: 3296: 3295: 3294: 3291: 3290: 3287: 3284: 3280: 3277: 3276: 3275: 3274:Diaphragmatic 3272: 3271: 3269: 3267: 3263: 3260: 3256: 3246: 3243: 3241: 3238: 3236: 3233: 3229: 3226: 3224: 3221: 3219: 3216: 3214: 3211: 3210: 3209: 3206: 3205: 3203: 3201: 3197: 3191: 3188: 3184: 3181: 3179: 3176: 3175: 3174: 3173: 3169: 3168: 3165: 3162: 3160: 3157: 3155: 3151: 3148: 3144: 3141: 3139: 3136: 3134: 3131: 3130: 3129: 3126: 3125: 3123: 3121: 3115: 3111: 3105: 3102: 3100: 3097: 3095: 3092: 3090: 3087: 3085: 3082: 3080: 3079:Cholecystitis 3077: 3076: 3074: 3072: 3068: 3060: 3057: 3055: 3052: 3051: 3050: 3047: 3045: 3042: 3040: 3037: 3033: 3030: 3028: 3025: 3024: 3023: 3022:Liver abscess 3020: 3016: 3013: 3011: 3008: 3007: 3006: 3005:Liver failure 3003: 3001: 2998: 2994: 2991: 2989: 2986: 2984: 2981: 2979: 2976: 2975: 2974: 2973: 2969: 2965: 2962: 2961: 2960: 2957: 2953: 2950: 2949: 2948: 2945: 2941: 2938: 2936: 2933: 2931: 2928: 2927: 2926: 2923: 2922: 2920: 2918: 2914: 2911: 2909: 2905: 2897: 2894: 2893: 2892: 2889: 2885: 2882: 2880: 2877: 2876: 2875: 2872: 2870: 2867: 2866: 2864: 2862: 2858: 2848: 2845: 2843: 2840: 2838: 2835: 2833: 2830: 2828: 2824: 2821: 2820: 2818: 2816: 2812: 2806: 2803: 2801: 2798: 2796: 2793: 2791: 2788: 2784: 2781: 2780: 2779: 2776: 2775: 2773: 2771: 2767: 2761: 2758: 2754: 2751: 2750: 2749: 2746: 2742: 2739: 2738: 2737: 2734: 2732: 2729: 2727: 2724: 2722: 2719: 2717: 2713: 2710: 2708: 2705: 2703: 2700: 2698: 2694: 2693: 2689: 2685: 2682: 2681: 2680: 2677: 2675: 2672: 2668: 2665: 2664: 2663: 2662:Enterocolitis 2660: 2659: 2657: 2653: 2647: 2643: 2639: 2636: 2634: 2630: 2627: 2623: 2619: 2616: 2614: 2611: 2610: 2609: 2606: 2604: 2601: 2597: 2594: 2592: 2589: 2587: 2584: 2582: 2579: 2577: 2574: 2572: 2569: 2568: 2567: 2564: 2562: 2559: 2558: 2556: 2553: 2549: 2544: 2540: 2534: 2531: 2529: 2526: 2524: 2521: 2519: 2516: 2514: 2511: 2509: 2506: 2504: 2501: 2499: 2496: 2494: 2490: 2489:Malabsorption 2487: 2483: 2480: 2479: 2478: 2475: 2471: 2468: 2466: 2463: 2461: 2458: 2457: 2456: 2453: 2452: 2450: 2447: 2443: 2439: 2434: 2430: 2427: 2425: 2421: 2417: 2405: 2402: 2401: 2400: 2397: 2395: 2392: 2390: 2387: 2385: 2382: 2380: 2377: 2375: 2372: 2370: 2367: 2365: 2364:Gastroparesis 2362: 2360: 2357: 2355: 2352: 2348: 2345: 2344: 2343: 2340: 2336: 2333: 2331: 2330:Cushing ulcer 2328: 2327: 2326: 2323: 2319: 2316: 2314: 2311: 2309: 2306: 2305: 2304: 2301: 2300: 2298: 2296: 2292: 2286: 2283: 2281: 2278: 2276: 2275:Megaesophagus 2273: 2271: 2268: 2266: 2263: 2260: 2257: 2252: 2249: 2247: 2244: 2242: 2239: 2237: 2234: 2232: 2229: 2228: 2227: 2224: 2222: 2219: 2217: 2214: 2210: 2207: 2205: 2202: 2201: 2200: 2197: 2193: 2190: 2188: 2185: 2183: 2180: 2179: 2178: 2175: 2174: 2172: 2170: 2166: 2163: 2161: 2157: 2153: 2145: 2140: 2138: 2133: 2131: 2126: 2125: 2122: 2109: 2105: 2104: 2100: 2098: 2094: 2093: 2089: 2088: 2085: 2081: 2074: 2070: 2069: 2065: 2063: 2059: 2058: 2054: 2052: 2048: 2047: 2043: 2039: 2036: 2032: 2031: 2027: 2023: 2022: 2019: 2014: 2010: 1994: 1990: 1985: 1980: 1976: 1972: 1968: 1964: 1957: 1955: 1953: 1944: 1940: 1935: 1930: 1927:(2): 264–71. 1926: 1922: 1918: 1911: 1903: 1899: 1895: 1891: 1887: 1883: 1876: 1868: 1864: 1859: 1854: 1850: 1846: 1842: 1835: 1827: 1825:88-85037-75-5 1821: 1817: 1809: 1801: 1797: 1793: 1789: 1784: 1779: 1775: 1771: 1767: 1760: 1752: 1748: 1743: 1738: 1734: 1730: 1726: 1722: 1718: 1714: 1710: 1703: 1695: 1693:0-443-01007-2 1689: 1685: 1678: 1664:on 2007-05-22 1663: 1659: 1655:health a to z 1652: 1644: 1640: 1636: 1632: 1628: 1624: 1621:(5): 530–46. 1620: 1616: 1609: 1607: 1605: 1596: 1592: 1588: 1584: 1580: 1576: 1572: 1568: 1561: 1546:. MedlinePlus 1545: 1539: 1537: 1535: 1533: 1531: 1526: 1516: 1513: 1511: 1508: 1507: 1498: 1494: 1490: 1487: 1484: 1480: 1477: 1472: 1468: 1465: 1461: 1460: 1458: 1455: 1451: 1448: 1444: 1440: 1436: 1435:feeding tubes 1432: 1428: 1424: 1423: 1422: 1407: 1404: 1401: 1397: 1394: 1391: 1388: 1387: 1378: 1375:to determine 1374: 1370: 1368: 1364: 1361: 1359: 1355: 1352: 1348: 1344: 1341: 1340: 1331: 1328: 1325: 1322: 1319: 1315: 1312: 1309: 1305: 1302:aspirate and 1301: 1297: 1294: 1291: 1287: 1283: 1279: 1275: 1271: 1268: 1267: 1263: 1259: 1255: 1251: 1247: 1242: 1230: 1226: 1223: 1220: 1216: 1213: 1209: 1205: 1201: 1198: 1194: 1191: 1190: 1181: 1177: 1173: 1170: 1166: 1163: 1160: 1156: 1155: 1152:Stool studies 1146: 1142: 1138: 1134: 1131: 1127: 1124: 1120: 1116: 1112: 1111:micronutrient 1108: 1104: 1101: 1097: 1093: 1089: 1085: 1081: 1077: 1073: 1069: 1065: 1064: 1055: 1051: 1048: 1045: 1041: 1038: 1035: 1032:, as seen in 1031: 1028: 1027: 1026: 1018: 1015: 1003:insufficiency 1002: 999: 996: 992: 990: 986: 984: 980: 977: 973: 970: 967: 966: 965: 963: 959: 957: 952: 950: 946: 942: 938: 934: 930: 926: 922: 918: 914: 910: 906: 902: 898: 894: 877: 876: 875: 872: 871: 865: 863: 859: 856: 854: 851: 849: 845: 842: 835: 831: 828: 825: 823: 820: 818: 815: 813: 810: 808: 805: 803: 800: 799: 798: 796: 793:Due to other 791: 790: 785: 782: 778: 775: 773: 770: 768: 765: 764: 762: 757: 755: 752: 750: 747: 745: 742: 741: 740: 736: 735: 734: 731: 730: 725: 722: 719: 716: 713: 709: 708: 707: 704: 703: 697: 695: 692: 689: 687: 684: 683: 682: 679: 678: 673: 669: 666: 664: 661: 660: 659: 656: 655: 649: 646: 644: 641: 639: 636: 634: 630: 628: 624: 620: 616: 614: 610: 606: 603: 601: 598: 597: 596: 593: 592: 587: 584: 582: 579: 577: 574: 571: 567: 564: 560: 556: 552: 544: 540: 537: 534: 532: 528: 525: 522: 521: 520: 517: 516: 506:deficiencies. 505: 501: 497: 495: 491: 487: 483: 479: 475: 472: 468: 464: 460: 456: 449: 446: 444: 441:from loss of 440: 436: 433: 429: 426: 423: 419: 415: 411: 407: 403: 399: 395: 391: 388: 387: 386: 384: 375: 366: 364: 360: 356: 352: 348: 345:, folate, or 344: 340: 336: 332: 321: 319: 315: 311: 307: 302: 298: 293: 289: 285: 281: 277: 273: 258: 256: 252: 248: 247:malabsorption 244: 240: 239:malabsorption 235: 200: 196: 192: 188: 184: 180: 176: 172: 168: 164: 158: 156: 152: 148: 144: 140: 136: 135:Malabsorption 127: 123: 119: 115: 111: 107: 103: 99: 96: 92: 89: 85: 81: 77: 74: 72: 71:Complications 68: 64: 62: 58: 55: 51: 47: 43: 39: 35: 30: 27:Malabsorption 25: 19: 3352: 3331: 3208:Pancreatitis 3170: 3120:biliary tree 2993:Nutmeg liver 2970: 2896:Hematochezia 2847:Pruritus ani 2832:Anal abscess 2827:Anal fistula 2823:Anal fissure 2736:Constipation 2690: 2561:Appendicitis 2488: 2369:Gastroptosis 2359:Achlorhydria 2198: 2187:Eosinophilic 2101: 2090: 2066: 2055: 2040: 2024: 1966: 1924: 1920: 1910: 1888:(5): 531–6. 1885: 1881: 1875: 1848: 1844: 1834: 1815: 1808: 1773: 1769: 1759: 1716: 1712: 1702: 1683: 1677: 1666:. Retrieved 1662:the original 1651: 1618: 1614: 1570: 1566: 1560: 1548:. Retrieved 1427:electrolytes 1420: 1204:Barium enema 1180:Chymotrypsin 1169:steatorrhoea 1167:to diagnose 1100:osteomalacia 1088:macrocytosis 1049: 1039: 1029: 1024: 1011: 960: 953: 944: 936: 925:electrolytes 909:carbohydrate 890: 873: 866:Malnutrition 792: 732: 705: 680: 657: 594: 569: 562: 554: 538: 531:tuberculosis 518: 494:osteoporosis 490:osteomalacia 437:Swelling or 417: 398:carbohydrate 394:steatorrhoea 380: 369:Presentation 349:absorption. 327: 286:, abdominal 282:, abdominal 269: 246: 238: 236: 159: 151:malnutrition 134: 133: 84:steatorrhoea 76:Malnutrition 18: 3388:Peritonitis 3150:Cholestasis 3128:Cholangitis 3071:Gallbladder 2959:Fatty liver 2879:Hematemesis 2861:GI bleeding 2667:Necrotizing 2596:Lymphocytic 2591:Collagenous 2586:Microscopic 2523:Steatorrhea 2424:Enteropathy 2270:Inlet patch 2192:Herpetiform 2177:Esophagitis 2092:MedlinePlus 1452:Pancreatic 1443:jejunostomy 1412:deficiency. 1324:Colonoscopy 1296:Enteroscopy 1258:hyperplasia 1246:small bowel 1125:deficiency. 1070:may reveal 1068:blood tests 1061:Blood tests 995:enteropathy 974:Defects of 903:nutrients ( 668:Gastrectomy 619:amyloidosis 609:diverticula 600:Blind loops 529:Intestinal 434:in children 402:electrolyte 359:steatorrhea 347:vitamin B12 292:steatorrhea 276:weight loss 145:across the 54:macrophages 3424:Categories 3380:Peritoneal 3358:Incisional 3279:Congenital 3223:Hereditary 3200:Pancreatic 3164:Haemobilia 2837:Hemorrhoid 2815:Anal canal 2753:Infectious 2741:Functional 2576:Ulcerative 2460:Duodenitis 2399:Gastrinoma 2068:DiseasesDB 1847:(Review). 1668:2007-05-10 1521:References 1479:Antibiotic 1431:dietitians 1417:Management 1310:overgrowth 1272:to detect 1262:lymphocyte 1244:Biopsy of 1092:folic acid 1001:Pancreatic 983:hydrolysis 969:Congenital 962:Intestinal 737:Bile acid/ 613:strictures 551:giardiasis 502:and other 459:folic acid 414:flatulence 406:fatty acid 383:intestinal 339:macrocytic 335:osteopenia 301:bile acids 280:flatulence 199:pancreatic 191:intestinal 139:absorption 52:with many 3368:Richter's 3325:Spigelian 3320:Obturator 3310:Umbilical 3143:Ascending 3114:Bile duct 2947:Cirrhosis 2925:Hepatitis 2908:Accessory 2778:Proctitis 2629:Megacolon 2603:Dysentery 2513:Whipple's 2465:Jejunitis 2455:Enteritis 2342:Dyspepsia 2303:Gastritis 2236:Achalasia 2169:Esophagus 2103:eMedicine 1733:2042-0986 1615:Digestion 1491:or other 1400:bile salt 1396:Bile salt 1308:bacterial 1210:or ileal 1123:vitamin K 1107:vitamin D 1030:selective 1008:Diagnosis 987:Impaired 978:transport 956:digestion 933:enzymatic 929:Digestion 832:(lack of 566:roundworm 536:Parasites 500:vitamin K 482:vitamin D 452:vitamin B 390:Diarrhoea 167:potassium 125:Treatment 88:diarrhoea 61:Specialty 3440:Diarrhea 3298:Indirect 3293:Inguinal 3027:Pyogenic 2972:Vascular 2748:Diarrhea 2726:Volvulus 2692:Vascular 2631: / 2620: / 2581:Ischemic 2548:Appendix 2438:Duodenum 2308:Atrophic 2182:Candidal 2108:med/1384 1993:12801941 1867:28244672 1800:10373517 1792:12192177 1751:25083257 1643:46786949 1595:12239612 1587:10348832 1550:29 April 1504:See also 1390:D-xylose 1274:duodenal 1256:, crypt 1248:showing 1219:pancreas 1176:elastase 1066:Routine 1014:symptoms 917:vitamins 672:Vagotomy 623:lymphoma 605:Fistulae 559:hookworm 448:Anaemias 410:bloating 392:, often 284:bloating 272:Diarrhea 183:Salivary 179:vitamins 171:chloride 155:anaemias 3339:Petit's 3315:Femoral 3218:Chronic 3032:Amoebic 2800:Anismus 2566:Colitis 2493:Coeliac 2470:Ileitis 2442:Jejunum 2295:Stomach 2199:Rupture 2062:D008286 1984:1867765 1943:7350049 1902:1744388 1742:4110863 1635:9705537 1454:enzymes 1363:Lactose 1304:culture 1300:jejunal 1212:lesions 1208:colonic 1200:anatomy 1159:Giardia 1135:or IgA 1080:albumin 1078:or low 1074:, high 1072:anaemia 1040:partial 951:cells. 913:protein 486:calcium 476:Muscle 443:protein 432:puberty 351:Purpura 195:hepatic 187:gastric 175:calcium 80:anaemia 3333:Lumbar 3303:Direct 3286:Hiatus 3266:Hernia 3118:Other 2884:Melena 2770:Rectum 2253:(GERD) 2097:000299 1991:  1981:  1941:  1900:  1865:  1822:  1798:  1790:  1749:  1739:  1731:  1690:  1641:  1633:  1593:  1585:  1343:SeHCAT 1278:biopsy 1260:, and 901:absorb 897:digest 895:is to 568:, and 511:Causes 439:oedema 331:anemia 288:cramps 197:, and 163:sodium 94:Causes 50:villus 3258:Other 3213:Acute 2964:MASLD 2917:Liver 2891:Lower 2874:Upper 2716:Ileus 2552:Colon 2446:Ileum 2261:(LPR) 1796:S2CID 1639:S2CID 1591:S2CID 1280:(for 1254:villi 1113:like 1050:total 478:cramp 230:, or 46:eosin 2646:SCAD 2073:7698 2057:MeSH 2046:9-CM 1989:PMID 1939:PMID 1898:PMID 1863:PMID 1820:ISBN 1788:PMID 1747:PMID 1729:ISSN 1688:ISBN 1631:PMID 1583:PMID 1552:2018 1373:EDTA 1330:ERCP 1306:for 1229:ERCP 1139:for 1115:zinc 919:and 899:and 860:and 846:and 611:and 539:e.g. 492:and 461:and 418:e.g. 400:and 343:iron 333:and 2952:PBC 2679:IBD 2613:IBS 2051:579 2042:ICD 2035:K90 2033:: ( 2026:ICD 1979:PMC 1971:doi 1967:Gut 1929:doi 1890:doi 1853:doi 1778:doi 1737:PMC 1721:doi 1623:doi 1575:doi 1571:116 1270:OGD 1130:IgA 1109:or 1096:B12 1094:or 1076:CRP 976:ion 905:fat 836:, B 557:), 524:HIV 420:in 312:or 216:HCO 141:of 3426:: 3116:/ 2714:: 2695:: 2491:: 2106:: 2095:: 2071:: 2060:: 2049:: 2030:10 1987:. 1977:. 1965:. 1951:^ 1937:. 1925:78 1923:. 1919:. 1896:. 1886:13 1884:. 1861:. 1849:32 1843:. 1794:. 1786:. 1774:35 1772:. 1768:. 1745:. 1735:. 1727:. 1715:. 1711:. 1637:. 1629:. 1619:59 1617:. 1603:^ 1589:. 1581:. 1569:. 1529:^ 1410:12 1288:, 1284:, 1202:. 1147:). 943:. 927:. 911:, 907:, 838:12 670:; 625:, 621:, 607:, 547:12 541:, 484:, 469:, 457:, 454:12 412:, 353:, 278:, 274:, 257:. 234:. 232:Mg 228:Ca 226:, 214:, 212:Cl 210:, 206:, 204:Na 193:, 189:, 185:, 177:, 173:, 169:, 165:, 157:. 116:; 112:; 108:; 104:; 100:; 86:; 82:; 78:; 3152:/ 2825:/ 2644:/ 2640:/ 2554:) 2550:/ 2546:( 2448:) 2444:/ 2440:/ 2436:( 2143:e 2136:t 2129:v 2044:- 2037:) 2028:- 2018:D 1995:. 1973:: 1945:. 1931:: 1904:. 1892:: 1869:. 1855:: 1828:. 1802:. 1780:: 1753:. 1723:: 1717:4 1696:. 1671:. 1645:. 1625:: 1597:. 1577:: 1554:. 1499:. 1485:. 1473:. 1466:. 1379:. 1353:. 1231:. 1221:. 1214:. 1143:( 1056:. 1046:. 1036:. 997:) 572:) 561:( 553:( 222:3 219:− 208:K

Index


Whipple's disease
eosin
villus
macrophages
Specialty
Complications
Malnutrition
anaemia
steatorrhoea
diarrhoea
Coeliac disease
short bowel syndrome
lactase deficiency
exocrine pancreatic insufficiency
small intestinal bacterial overgrowth
Whipple's disease
absorption
food nutrients
gastrointestinal (GI) tract
malnutrition
anaemias
sodium
potassium
chloride
calcium
vitamins
Salivary
gastric
intestinal

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