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unclear whether amyloid beta was a byproduct of neuronal degeneration or a contributor to that degeneration. This paper provided the first direct evidence that a fragment of the amyloid precursor protein could kill neurons, and helped stimulate a very large field dedicated to preventing and treating
Alzheimer's disease by targeting amyloid beta.
257:. She was the eldest of six children; her father, John, was a teacher and musician and her mother, Drucilla, was a social worker. By the age of nine, Villa-Komaroff knew that she wanted to be a scientist, influenced in part by her uncle, a chemist. She was also inspired due to her mother's and grandmother's love for both nature and plants.
423:
The laboratory identified several proteins that help vision develop in very young animals. Other scientists had discovered that the development of normal vision in cats is delayed when cats are raised in total darkness and that the development of vision can be triggered by brief exposure to light.
368:. Within 6 months, she was the first author of the landmark report from the Gilbert laboratory showing that bacteria could be induced to make proinsulin– the first time a mammalian hormone was synthesized by bacteria. The research was a milestone in the birth of the biotechnology industry.
434:
Finally, Villa-Komaroff contributed to the discovery that a molecule known to be associated with
Alzheimer's disease (amyloid beta) causes degeneration of brain cells (neurons), work done in conjunction with a postdoctoral fellow in her laboratory, Bruce Yankner. Before this publication, it was
379:
with a lighter teaching workload and more research opportunities including her research on transforming growth factor- α and epidermal growth factor during fetal and neonatal development published in 1992 and 1993. There, she continued to establish her name in molecular biology, and in 1995 a
424:
Villa-Komaroff's laboratory showed that exposing dark-reared cats to one hour of light caused a 2 to 3 fold transient induction of three specific proteins. This finding directly linked the expression of these genes with an environmental trigger (light) in the development of vision.
232:
419:
to address a number of fundamental questions in different fields, in collaboration with neurologists, developmental biologists, endocrinologists, and cell biologists. Villa-Komaroff's laboratory made several important contributions following the insulin research.
360:
Villa-Komaroff felt that these failures aided in her biggest victory: six months after she was able to return to
Harvard (once the ban on recombinant DNA experiments was lifted in 1977), she became a postdoctoral fellow in the laboratory of
357:. While at Cold Spring Harbor, she experienced repeated failures of her experiments; however, these disappointments taught her that “most experiments fail, and that scientists must accept failure as a part of the process”.
231:
832:
403:. Since 2005, she has served as a senior executive and board member of several biotechnology companies. She also continues to serve on the boards and committees of several major public and private institutions.
233:
1623:
1415:
is a series of 60-second historical profiles of MIT students, researchers, and staff that demonstrates the role of women at the
Institute from its founding to today." Retrieved 22 April 2017.
599:
705:
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Yankner, BA; Dawes, LR; Fisher, S; Villa-Komaroff, L; Oster-Granite, ML; Neve, RL (1989). "Neurotoxicity of a fragment of the amyloid precursor associated with
Alzheimer's disease".
1290:
1320:
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where she served as vice president for
Research of the university. In 2003 she returned to Boston, where she became the Vice President for Research and Chief Operating Officer of
187:(born August 7, 1947) is a molecular and cellular biologist who has been an academic laboratory scientist, a university administrator, and a business woman. She was the third
289:. It is believed that she applied to Johns Hopkins University, but was not accepted because they were not accepting women at that time. In 1970, she married her boyfriend, Dr.
319:. She dedicated her thesis to her colleagues David Rekosh and David Housman, who she says "taught me to walk," and her advisors who "taught me what it might be like to fly."
195:
to receive a doctorate degree in the sciences (1975) and is a co-founding member of The
Society for the Advancement of Chicanos/Hispanics and Native Americans in Science (
199:). Her most notable discovery was in 1978 during her post-doctoral research, when she was part of a team that discovered how bacterial cells could be used to generate
839:
1044:
Yankner, BA; Benowitz, LI; Villa-Komaroff, L; Neve, RL (1990). "Transfection of the human GAP-43 gene in PC12 cells: effects on neurite outgrowth and regeneration".
224:
322:
In 1973, while still a graduate student at MIT, she became a founding member of the
Society for Advancement of Chicanos and Native Americans in Science (SACNAS).
571:
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as a chemistry major. When an advisor told her that "women do not belong in chemistry" she switched majors, settling on biology. In 1967, she transferred to
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After her participation in the landmark research reporting the first synthesis of mammalian insulin in bacterial cells, Villa-Komaroff used the then-new
815:
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banned such experiments in 1976, citing worries about public safety and the chance of unintentionally creating a new disease, Villa-Komaroff moved to
1583:
1593:
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1475:
1347:
709:
822:". Committee on Equal Opportunities in Science and Engineering (CEOSE), National Science Foundation. nsf.gov. Retrieved 22 April 2017.
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television documentary called "DNA Detective" featured her work on insulin-related growth factors. The segment ran as part of a six-part
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375:(UMMS), where she was a professor for six years before being granted tenure. The following year, she left for a position at
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Chief
Scientific Officer & Member of the Board, 2003-2004; Chief Executive Officer & Chair of the Board, 2005,
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1158:
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861:
Villa-Komaroff, L; Efstratiadis, A; Broome, S; Lomedico, P; Tizard, R; Naber, SP; Chick, WL; Gilbert, W (Aug 1978).
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Chief
Scientific Officer, 2005; Chief Executive Officer 2006-2009; Chief Scientific Officer, 2009-2014,
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Member of the US delegation to the Asian-Pacific Economic Conference-Women and the Economy Forum, 2012
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304:(MIT) for graduate work in molecular biology. Her PhD dissertation, under the supervision of
1429:
1394:". March for Science. marchforscience.com. 30 March 2017. Retrieved 22 April 2017.
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987:"Brief visual experience induces immediate early gene expression in the cat visual cortex"
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2014 Distinguished Lecturer for the STEM Diversity Institute and the Five Colleges, Inc
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1994 Participant in the 1994 Forum on Science in the National Interest - White House
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1321:"Regis College announces two honorary degree recipients and commencement speaker"
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706:"Hooray for women in STEM! Meet Lydia Villa-Komaroff 2013 Women of Distinction"
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Committee on the Expansion of the Science and Engineering Workforce Pipeline
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1999 Induction into the Hispanic Engineer National Achievement Hall of Fame
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1291:"Breaking Barriers: World-Renowned Molecular Biologist Blazes New Trails"
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773:"Lydia Villa-Komaroff Learned in the Lab 'What It Might Be Like to Fly'"
581:
Committee on Assessing the System for Protecting Human Research Subjects
956:"Villa-Komaroff to Present SDI and Five Colleges Distinguished Lecture"
600:
Society for the Advancement of Chicanos and Native Americans in Science
391:
In 1996, Villa-Komaroff left laboratory research, and was recruited to
316:
245:
1426:"Lydia Villa-Komaroff | Biography, Insulin, & SACNAS | Britannica"
1411:. Massachusetts Institute of Technology. teachingexcellence.mit.edu. "
1175:"Lydia Villa-Komaroff Among 100 Most Influential Hispanics in America"
500:
2011 Leadership Award, Women Entrepreneurs in Science & Technology
708:. American Association of University Women. aauw.org. Archived from
654:
522:
2016 Morison Prize, MIT Program in Science, Technology & Society
833:"Education, Preparation & Passion: Lydia Villa-Komaroff, Ph.D."
278:
1624:
Fellows of the American Association for the Advancement of Science
985:
Rosen, KM; McCormack, MA; Villa-Komaroff, L; Mower, G (Jun 1992).
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741:. Independence (KY): Gale, Cengage Learning. 2014. Archived from
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in Cambridge, Massachusetts, an affiliated research institute of
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Committee on Women in Science, Engineering, and Medicine (CWSEM)
253:
Lydia Villa-Komaroff was born on August 7, 1947, and grew up in
294:
196:
1392:
March for Science Announces Three Honorary National Co-Chairs
588:
Committee on the Equal Opportunity in Science and Engineering
503:
2012 MAKERS selection, and video, as a prominent woman leader
638:
1153:. Thousand Oaks (CA): Sage Publications, Inc. p. 151.
619:
Chief Operating Officer & Vice President for Research,
406:
1451:"Board of Directors | Massachusetts Life Sciences Center"
431:
was important in the growth of the axons of nerve cells.
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130:
921:
Invisible Frontiers: The Race to Synthesize a Human Gene
684:
478:
2008 Lifetime Achievement award, Hispanic Business Media
427:
The laboratory also discovered direct evidence that the
667:
Member of the Board, Chair of the Executive Committee,
572:
National Institute of Neurological Disorders and Stroke
371:
Later in the same year, she joined the faculty of the
598:
Founding member, 1973; Board member; Vice President,
579:
National Academy of Medicine (Institute of Medicine)
1205:
American Association for the Advancement of Science
614:
American Association for the Advancement of Science
464:
American Association for the Advancement of Science
315:, focused on how proteins are produced from RNA in
1230:. Santa Barbara (CA): ABC-CLIO, LLC. p. 941.
813:CEOSE - Member Biography: Dr. Lydia Villa-Komaroff
1146:
779:. The American Society for Cell Biology. ascb.org
450:1992 Hispanic Engineer National Achievement Award
1545:
516:2015 Distinguished Women Scientist, White House
388:, under the umbrella title "Discovering Women."
225:Lydia Villa-Komaroff (As Told By Jo Handelsman)
1619:Hispanic and Latino American women scientists
1476:"Board of Trustees - Keck Graduate Institute"
1258:
1256:
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469:2008 Catalyst Award - Science Club for Girls
1348:"WEST honors four women technology leaders"
1223:
863:"A bacterial clone synthesizing proinsulin"
1405:Storied Women of MIT: Lydia Villa-Komaroff
1251:
1179:Whitehead Institute of Biomedical Research
373:University of Massachusetts Medical School
29:
1288:
1123:"Celebrating Historical Women in Science"
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1010:
923:. New York: Atlantic Monthly Press.
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561:National Research Council (United States)
554:National Research Council (United States)
547:National Research Council (United States)
540:National Research Council (United States)
525:2017 Honorary Co-Chair, March for Science
508:American Association of University Women
407:Research discoveries and accomplishments
300:In 1970, Villa-Komaroff enrolled at the
206:
106:American Association of University Women
1584:Hispanic and Latino American scientists
1345:
1147:Stange MZ, Oyster CK, Sloan JE (2011).
518:Office of Science and Technology Policy
455:Office of Science and Technology Policy
260:
1594:21st-century American women scientists
1589:20th-century American women scientists
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1150:Encyclopedia of Women in Today's World
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487:University of Saint Thomas (Minnesota)
474:Museum of Science and Industry (Tampa)
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481:1996-2011 Honorary Doctoral Degrees,
472:2008 Hispanic Scientist of the Year,
302:Massachusetts Institute of Technology
80:Massachusetts Institute of Technology
1227:American Women of Science Since 1990
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661:
549:Committee on Underrepresented Groups
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960:University of Massachusetts Amherst
799:"Biography of Lydia Villa-Komaroff"
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16:Mexican American cellular biologist
13:
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1268:Massachusetts Life Sciences Center
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685:Biomedical Science Careers Program
655:Massachusetts Life Sciences Center
281:, when her boyfriend moved to the
213:
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1635:
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771:Weiler, Nicholas (30 July 2014).
673:Member of the Board of Trustees,
563:Committee on the Structure of NIH
532:
285:metropolitan area to work at the
104:2013 Woman of Distinction by the
1609:People from Santa Fe, New Mexico
1604:21st-century American biologists
1599:20th-century American biologists
446:Association for Women in Science
325:She completed her PhD at MIT in
244:Problems playing this file? See
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1282:
1217:
1201:"AAAS Historic Fellows Listing"
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978:
1534:Makers: Women Who Make America
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704:Shury, Nzinga (4 April 2014).
1:
1579:American molecular biologists
962:. 27 Mar 2014. Archived from
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679:Claremont Colleges Consortium
605:Vice President for Research,
495:Regis College (Massachusetts)
355:Cold Spring Harbor Laboratory
337:for three years, focusing on
287:National Institutes of Health
1503:. 2024-01-13. Archived from
1478:. 2024-01-04. Archived from
1453:. 2017-02-20. Archived from
1428:. 2024-02-07. Archived from
1058:10.1016/0169-328x(90)90071-k
528:2017 Storied Women of M.I.T.
161:Other academic advisors
35:Lydia Villa-Komaroff in 2013
7:
593:National Science Foundation
586:National Science Foundation
506:2013 Woman of Distinction,
341:, under the supervision of
10:
1640:
1614:Biologists from New Mexico
1564:Women molecular biologists
1409:Teaching Excellence at MIT
643:Chair, Board of Trustees,
339:recombinant DNA technology
329:in 1975. She then went to
293:, and the couple moved to
944:– via www.imdb.com.
919:Hall, Stephen S. (1987).
265:In 1965, she entered the
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1559:American women academics
1289:Molina J. (7 Jan 2009).
267:University of Washington
1352:Boston Business Journal
1101:10.1126/science.2474201
1012:10.1073/pnas.89.12.5437
675:Keck Graduate Institute
628:Transkaryotic Therapies
607:Northwestern University
393:Northwestern University
139:Northwestern University
1574:Goucher College alumni
1374:"Lydia Villa-Komaroff"
1346:Lang M. (9 Jun 2011).
997:(5437–5431): 5437–41.
991:Proc Natl Acad Sci USA
888:10.1073/pnas.75.8.3727
867:Proc Natl Acad Sci USA
377:Harvard Medical School
218:
653:Member of the Board,
632:Shire Pharmaceuticals
335:postdoctoral research
217:
207:Early life and family
1529:Lydia Villa-Komaroff
1413:Storied Women of MIT
1264:"Board of Directors"
1224:Vitetta ES. (2011).
966:on 19 September 2015
738:Lydia Villa-Komaroff
612:Board of Directors,
261:Education and career
255:Santa Fe, New Mexico
185:Lydia Villa-Komaroff
23:Lydia Villa-Komaroff
1501:"Leadership | BSCP"
1093:1989Sci...245..417Y
1003:1992PNAS...89.5437R
942:"Discovering Women"
879:1978PNAS...75.3727V
621:Whitehead Institute
595:Biology Directorate
462:2008 Fellow of the
397:Whitehead Institute
291:Anthony L. Komaroff
95:Anthony L. Komaroff
1531:Video produced by
818:2018-08-25 at the
645:Pine Manor College
491:Pine Manor College
219:
135:Harvard University
1295:Hispanic Business
1087:(4916): 417–420.
662:Current positions
439:Awards and honors
413:molecular biology
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122:Molecular Biology
113:Scientific career
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1301:on 11 March 2014
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712:on 26 March 2017
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683:Vice President,
574:Advisory Council
386:women in science
283:Washington, D.C.
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189:Mexican-American
146:Doctoral advisor
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483:Goucher College
441:
417:recombinant DNA
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333:to conduct her
313:David Baltimore
275:Goucher College
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366:Walter Gilbert
363:Nobel laureate
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1507:on 2024-01-13
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1327:. 15 Apr 2010
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