273:
414:-labeled lipiodol. The radioactive lipiodol is attracted to the tumor, much like regular lipiodol. Its radioactivity destroys tumor tissue. However, I-lipiodol has been withdrawn from the market by its European manufacturer due to risk of embolism, especially in patients with hepatic arterio-venous shunting. I-lipidol is also less tumor-targeted than the microbeads used in conventional TARE procedures, requiring much higher radiation doses. It remains available in India, where its cost-effectiveness over conventional Y TARE is valued.
464:
salt. Beyond poppyseed oil, locally-available rapeseed (Brassiodol), peanut, walnut, and soybean oils have also been used for producing iodized oil for oral use. These iodized oils have different pharmacological profiles, but have also proven successful in eradicating goiter at a lower cost. In fact, iodized rapeseed and peanut oils provide longer-lasting protection from goiter compared to
Lipiodol.
2079:
516:
version, Lipiodol Ultra Fluide, was proposed by
Wallace specifically for this purpose in 1960. In 1981, Japanese professor Konno found that when Lipidol is injected into the hepatic artery of patients with hepatocarcinoma, the oily substance is selectively retained by the tumor for several months. He mixed Lipidol with a new drug SMANCS to selectively target cancer cells; thus,
378:(HSG: a procedure to determine tubal patency , used in the investigation of subfertility). It became less commonly utilized in the 1960s to 1980s because the more modern water-soluble media give images that are easier to interpret. There is also an important safety issue with Lipiodol in that intravasation (leakage) of the fluid into the venous system has caused
515:
by two French physicians, Jacques
Forestier and Jean Sicard in 1921). It was first used for lymphography in 1960 as a replacement for the earlier water-soluble contrasts, which quickly diffused outside the lymphatic network and prevented visualization beyond the first few nodes. A transesterified
463:
Iodized poppyseed oil (Lipiodol) given orally or intermuscularly produces a long-lasting store of iodine in the body, allowing very infrequent dosing. Iodized oil is a cost-effective way of combating iodine deficiency. There seems to be a lower risk of initial hyperthyroidism compared to iodized
338:
Iodized oil was first made in 1901 by Marcel
Guerbet and Laurent Lafay. Originally used to treat iodine deficiency, it was identified as an effective radiocontrast in 1921 by Sicard and Forestier, before returning as a tool to treat iodine deficiency in goiter eradication campaigns of the 1980s.
1258:
Markou KB, Georgopoulos NA, Makri M, Vlasopoulou B, Anastasiou E, Vagenakis GA, et al. (2003). "Improvement of iodine deficiency after iodine supplementation in schoolchildren of
Azerbaijan was accompanied by hypo and hyperthyrotropinemia and increased title of thyroid autoantibodies".
527:
to fight endemic goitre via intramuscular injection. The technique received increasing approval and refinement as a supplement to salt iodization from the Pan
American Health Organisation, UNICEF, and WHO. In 1989, it was added to the WHO Model List of Essential Medications.
1062:
Andreana L, Isgrò G, Marelli L, Davies N, Yu D, Navalkissoor S, et al. (October 2012). "Treatment of hepatocellular carcinoma (HCC) by intra-arterial infusion of radio-emitter compounds: trans-arterial radio-embolisation of HCC".
459:
Lipiodol is given once or twice yearly to remote communities at risk of endemic goitre. The oil can be taken orally or injected intermuscularly. There is also an oral capsule that contains the oil, equivalent to 190 mg iodine.
438:
Since the 2000s, a small number of studies have suggested that flushing lipiodol through the fallopian tubes (similar to what is done in HSG, but without imaging) might provide a short-term rise in fecundity in patients with
1098:
Qian Y, Liu Q, Li P, Han Y, Zhang J, Xu J, et al. (February 2021). "Highly Tumor-Specific and Long-Acting Iodine-131 Microbeads for
Enhanced Treatment of Hepatocellular Carcinoma with Low-Dose Radio-Chemoembolization".
311:
that is used to outline structures in radiological investigations. When given orally or by intramuscular injection once or twice a year, it prevents endemic goitre in remote communities. It has an additional use in
539:
supplied thiodized oil for interventional procedure under the brand name "Ethiodol" to the US market until 2011, when the product was discotinued. The
Ethiodol product is equivalent to Lipiodol Ultra Fluide.
398:
into lipiodol to form a suspension. Guided by an imaging system, a catheter is moved into an artery that feeds the tumor and injects the suspension. Lipiodol helps retain the drug around the cancer cells. An
984:
de Baere T, Arai Y, Lencioni R, Geschwind JF, Rilling W, Salem R, et al. (March 2016). "Treatment of Liver Tumors with
Lipiodol TACE: Technical Recommendations from Experts Opinion".
451:
when using
Lipiodol flushing. A 2020 Cochrane review suggests that flushing with oil-soluble contrast media such as lipiodol may increase the chance of live birth and clinical pregnancy.
331:
referring to the risk of embolism. Use as iodine supplementation is recommended in regions where deficiency is common, otherwise it is not recommended. It should not be used for
1144:"Transarterial Radioembolization (TARE) with Iodine-Lipiodol for Unresectable Primary Hepatocellular Carcinoma: Experience from a Tertiary Care Center in India"
536:
112:
1755:
496:
are iodinated. The product is washed and purified to remove any free elemental iodine and other organic compounds, leaving only the iodinated esters.
1366:
Ingenbleek Y, Jung L, FĂ©rard G, Bordet F, Goncalves AM, Dechoux L (November 1997). "Iodised rapeseed oil for eradication of severe endemic goitre".
548:
444:
504:
Lipiodol was first synthesized by Marcel Guerbet in the Paris School of Pharmacy in 1901. It was originally used to treat iodine deficiency.
52:
1943:
1938:
597:
Ahrar K, Gupta S (January 2003). "Hepatic artery embolization for hepatocellular carcinoma: technique, patient selection, and outcomes".
492:
using silylated reagents, then reacting the acid with fatty acid ethyl esters. Sufficient amounts of the acid is used to ensure that all
488:, primarily as ethyl monoiodostearate and ethyl diiodostearate. One method to produce the oil involves turning iodine into anhydrous
1524:
850:"Multidetector-row computed tomography in the management of hepatocellular carcinoma with transcatheter arterial chemoembolization"
391:
364:
752:
2033:
1347:
1240:
1027:
Ahmadzadehfar H, Sabet A, Wilhelm K, Biersack HJ, Risse J (November 2011). "Iodine-131-lipiodol therapy in hepatic tumours".
914:
733:
340:
89:
1849:
696:
367:
applications as a contrast agent in follow-up imaging. Lipiodol is also used in lymphangiography, the imaging of the
2050:
1409:
Untoro J, Schultink W, Gross R, West CE, Hautvast JG (March 1998). "Efficacy of different types of iodised oil".
447:. A 2005 systematic review has suggested a significant increase in fertility, especially in those women who have
407:
153:
70:
410:" (TARE) is a similar procedure where the anticancer drug is radioactive. An experimental version of TARE uses
2099:
1982:
1517:
268:
221:
250:
1631:
569:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
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820:
674:
568:
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1915:
1510:
782:
523:
The use of Lipiodol against iodine deficiency was revived in 1957 by Mac Cullagh, who used it in
440:
379:
100:
34:
1491:
785:[The history of Lipiodol (1901-1994) or How a medication may evolve with the times].
375:
332:
941:
Johnson NP (2005). "A review of the use of lipiodol flushing for unexplained infertility".
423:
313:
301:
230:
194:
8:
2019:
1994:
1191:
Wang R, Watson A, Johnson N, Cheung K, Fitzgerald C, Mol BW, et al. (October 2020).
272:
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by mouth, injection (IM, intralymphatic, intrauterine, selective hepatic intra-arterial)
1930:
1831:
1434:
1391:
1339:
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1192:
1168:
1143:
1124:
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879:
783:"Histoire du Lipiodol (1901-1994) ou Comment un médicament peut évoluer avec son temps"
725:
508:
1422:
1379:
610:
323:
When used as tissue contrast, iodized oil has a risk of entering the vein and causing
1879:
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Gomi T, Hasegawa M (2012). "Radiological contrast agents and radiopharmaceuticals".
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Ethiodized oil for interventional procedure was solely produced and marketed by
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Medication derived from poppyseed oil and iodine often used as a contrast agent
997:
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1999:
1735:
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1649:
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632:
Sato T (April 2002). "Locoregional immuno(bio)therapy for liver metastases".
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Patel A, Subbanna I, Bhargavi V, Swamy S, Kallur KG, Patil S (April 2021).
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World Health Organization model list of essential medicines: 21st list 2019
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394:(TACE), a procedure for treating liver tumors. An anticancer drug is first
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2003:
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901:. Recent Results in Cancer Research. Vol. 157. pp. 109–20.
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324:
84:
1291:"Physiology and pharmacology of iodized oil in goiter prophylaxis"
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1791:
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1644:
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1330:
Medeiros-Neto G, Rubio IG (2016). "Iodine-Deficiency Disorders".
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material is then injected to restrict blood supply to the tumor.
400:
473:
297:
241:
983:
897:
Cabanas RM (2000). "The Concept of the Sentinel Lymph Node".
443:. This procedure is called Lipiodol flushing or more broadly
374:
Historically Lipiodol was often used as a contrast medium at
1365:
1141:
1061:
819:
673:
576:
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launched its oil under the brand name "Vividol" in 2022.
1408:
837:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
1190:
341:
World Health Organization's List of Essential Medicines
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as a dilutant that does not affect polymerization of
316:
as a dilutant that does not affect polymerization of
561:
47:
ethiodized oil, ethyl esters of iodised fatty acids
1329:
899:Lymphatic Metastasis and Sentinel Lymphonodectomy
2091:
1454:Journal of Vascular and Interventional Radiology
1452:Kolbeck KJ (March 2011). "Lipiodol = ethiodol".
780:
417:
1284:
1282:
936:
934:
753:"DailyMed - LIPIODOL- ethiodized oil injection"
677:(2009). Stuart MC, Kouimtzi M, Hill SR (eds.).
339:Under the name "iodine", iodized oil is on the
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1361:
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1279:
1097:
931:
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88:
1241:"IODIZED OIL oral | MSF Medical Guidelines"
1197:The Cochrane Database of Systematic Reviews
986:CardioVascular and Interventional Radiology
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747:
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854:Journal of Gastroenterology and Hepatology
681:. World Health Organization. p. 499.
599:Surgical Oncology Clinics of North America
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827:. Geneva: World Health Organization.
507:Historically, Lipiodol was the first
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61:
1498:. U.S. National Library of Medicine.
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454:
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135:
124:
327:in the brain and lungs. There is a
13:
1340:10.1016/B978-0-323-18907-1.00091-3
1332:Endocrinology: Adult and Pediatric
848:Guan YS, Hu Y, Liu Y (June 2006).
726:10.1016/b978-0-444-59499-0.00046-5
14:
2111:
1484:
1193:"Tubal flushing for subfertility"
390:Lipiodol is used in conventional
2077:
1308:10.1097/00005792-200101000-00003
955:10.2165/00024677-200504040-00004
867:10.1111/j.1440-1746.2006.04474.x
787:Revue d'Histoire de la Pharmacie
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781:Bonnemain B, Guerbet M (1995).
408:Transarterial radioembolization
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292:, is a medication derived from
1209:10.1002/14651858.CD003718.pub5
841:
705:
625:
590:
472:Ethiodized oil is composed of
343:, in liquid and capsule form.
1:
1423:10.1016/S0140-6736(05)78525-1
1380:10.1016/s0140-6736(97)02427-6
1148:South Asian Journal of Cancer
611:10.1016/s1055-3207(02)00089-3
554:
424:gastric variceal obliteration
418:Gastric variceal obliteration
314:gastric variceal obliteration
714:Side Effects of Drugs Annual
467:
422:It has an additional use in
7:
1041:10.1016/j.ymeth.2011.05.003
943:Treatments in Endocrinology
907:10.1007/978-3-642-57151-0_9
39:Lipiodol, Ethiodol, Vividol
10:
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1289:Wolff J (January 2001).
1065:Cancer Treatment Reviews
679:WHO Model Formulary 2008
509:iodinated contrast agent
63:International Drug Names
1916:Ferric ammonium citrate
1496:Drug Information Portal
1113:10.1021/acsnano.0c09122
799:10.3406/pharm.1995.4238
646:10.1053/sonc.2002.31716
441:unexplained infertility
434:Fallopian tube flushing
1160:10.1055/s-0041-1731600
376:hysterosalpingography
333:hysterosalpingography
2100:Radiocontrast agents
757:dailymed.nlm.nih.gov
634:Seminars in Oncology
2020:Sulfur hexafluoride
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537:Savage Laboratories
140:): goiter treatment
25:
2055:Never to phase III
1267:(2 Suppl): 43–48.
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1976:
1931:Superparamagnetic
1880:Gadopentetic acid
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1417:(9104): 752–753.
1349:978-0-323-18907-1
916:978-3-642-63070-5
735:978-0-444-59499-0
518:chemoembolization
455:Iodine deficiency
386:Chemoembolization
365:chemoembolization
356:Iodized oil is a
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2013:Microspheres of
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1334:. p. 1597.
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369:lymphatic system
363:. It is used in
300:. When given by
284:, also known as
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1900:Gadoversetamide
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1771:Water insoluble
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1751:Tyropanoic acid
1746:Sodium iopodate
1731:Iobenzamic acid
1721:Ioglycamic acid
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94:
93:
90:Ethiodized_oil
75:
73:
67:
66:
59:
49:
48:
45:
41:
40:
37:
31:
30:
15:
9:
6:
4:
3:
2:
2112:
2101:
2098:
2097:
2095:
2085:
2075:
2074:
2071:
2054:
2052:
2049:
2048:
2046:
2043:
2040:
2037:
2035:
2032:
2031:
2027:
2021:
2018:
2016:
2015:phospholipids
2012:
2010:
2007:
2005:
2001:
1998:
1996:
1995:human albumin
1992:
1989:
1988:
1986:
1984:
1980:
1970:
1967:
1966:
1964:
1960:
1954:
1953:nanoparticles
1950:
1947:
1945:
1942:
1940:
1937:
1936:
1934:
1932:
1928:
1922:
1919:
1917:
1913:
1910:
1909:
1906:
1903:
1901:
1898:
1896:
1893:
1891:
1888:
1886:
1883:
1881:
1878:
1876:
1873:
1871:
1868:
1866:
1863:
1861:
1858:
1856:
1852:
1851:
1847:
1846:
1844:
1842:
1838:
1835:
1833:
1829:
1819:
1816:
1815:
1813:
1811:Non-iodinated
1809:
1803:
1800:
1798:
1795:
1793:
1790:
1787:
1783:
1779:
1776:
1775:
1773:
1767:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1736:Iopanoic acid
1734:
1732:
1729:
1727:
1724:
1722:
1719:
1717:
1716:Iotroxic acid
1714:
1712:
1709:
1708:
1706:
1702:
1696:
1693:
1691:
1688:
1686:
1683:
1681:
1678:
1676:
1673:
1671:
1668:
1666:
1663:
1661:
1658:
1656:
1653:
1651:
1650:Ioxaglic acid
1648:
1646:
1643:
1641:
1638:
1637:
1635:
1633:
1629:Nephrotropic,
1627:
1621:
1618:
1616:
1613:
1611:
1610:Iocarmic acid
1608:
1606:
1603:
1601:
1600:Ioglicic acid
1598:
1596:
1593:
1591:
1588:
1586:
1583:
1581:
1578:
1576:
1573:
1572:
1570:
1568:
1564:Nephrotropic,
1562:
1559:
1557:Water soluble
1553:
1550:
1548:
1544:
1539:
1535:
1528:
1523:
1521:
1516:
1514:
1509:
1508:
1505:
1497:
1493:
1489:
1488:
1475:
1471:
1467:
1463:
1459:
1455:
1448:
1440:
1436:
1432:
1428:
1424:
1420:
1416:
1412:
1405:
1397:
1393:
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1377:
1373:
1369:
1362:
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1351:
1345:
1341:
1337:
1333:
1326:
1318:
1314:
1309:
1304:
1300:
1296:
1292:
1285:
1283:
1274:
1270:
1266:
1262:
1254:
1246:
1242:
1236:
1228:
1224:
1219:
1214:
1210:
1206:
1202:
1198:
1194:
1187:
1179:
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1170:
1165:
1161:
1157:
1153:
1149:
1145:
1138:
1130:
1126:
1122:
1118:
1114:
1110:
1106:
1102:
1094:
1086:
1082:
1078:
1074:
1070:
1066:
1058:
1050:
1046:
1042:
1038:
1034:
1030:
1023:
1015:
1011:
1007:
1003:
999:
995:
991:
987:
980:
972:
968:
964:
960:
956:
952:
948:
944:
937:
935:
926:
922:
918:
912:
908:
904:
900:
893:
885:
881:
877:
873:
868:
863:
859:
855:
851:
844:
835:
830:
826:
822:
816:
808:
804:
800:
796:
792:
789:(in French).
788:
784:
777:
775:
773:
771:
769:
767:
758:
754:
748:
746:
737:
731:
727:
723:
719:
715:
708:
700:
698:9789241547659
694:
689:
684:
680:
676:
670:
668:
666:
664:
655:
651:
647:
643:
639:
635:
628:
620:
616:
612:
608:
604:
600:
593:
578:
574:
570:
564:
560:
552:
550:
546:
541:
538:
532:Supply status
529:
526:
521:
519:
514:
510:
505:
497:
495:
491:
487:
486:poppyseed oil
483:
479:
476:reacted with
475:
465:
461:
452:
450:
449:endometriosis
446:
442:
431:
429:
428:cyanoacrylate
425:
415:
413:
409:
404:
402:
397:
393:
383:
382:in the past.
381:
380:complications
377:
372:
370:
366:
362:
359:
344:
342:
336:
334:
330:
329:boxed warning
326:
321:
319:
318:cyanoacrylate
315:
310:
307:
303:
299:
295:
294:poppyseed oil
291:
288:, brand name
287:
283:
274:
270:
267:
265:
263:ECHA InfoCard
259:
252:
251:ChEMBL1201458
248:
247:
245:
243:
239:
232:
228:
227:
225:
223:
219:
212:
211:
209:
207:
203:
196:
192:
191:
189:
187:
183:
178:
172:
160:
159:
157:
155:
151:
146:
138:
133:
127:
122:
119:
118:
116:
114:
110:
106:
104:
98:
91:
86:
77:
76:
74:
72:
68:
64:
60:
58:
54:
50:
46:
42:
38:
36:
32:
29:Clinical data
27:
19:
2009:Perflenapent
1991:Microspheres
1921:Mangafodipir
1911:
1885:Gadopiclenol
1870:Gadofosveset
1848:
1841:Paramagnetic
1797:Propyliodone
1782:Ethyl esters
1704:Hepatotropic
1567:high osmolar
1547:X-ray and CT
1495:
1457:
1453:
1447:
1414:
1410:
1404:
1371:
1367:
1331:
1325:
1301:(1): 20–36.
1298:
1294:
1264:
1260:
1253:
1244:
1235:
1200:
1196:
1186:
1154:(2): 81–86.
1151:
1147:
1137:
1104:
1100:
1093:
1068:
1064:
1057:
1032:
1028:
1022:
989:
985:
979:
946:
942:
898:
892:
857:
853:
843:
834:10665/325771
824:
815:
790:
786:
756:
717:
713:
707:
678:
637:
633:
627:
602:
598:
592:
580:. Retrieved
572:
563:
542:
535:
522:
506:
503:
494:double bonds
478:ethyl esters
471:
462:
458:
437:
421:
405:
389:
373:
358:radio-opaque
355:
347:Medical uses
337:
322:
306:radio-opaque
289:
285:
281:
280:
154:Legal status
148:Legal status
71:License data
18:
2041:from market
1895:Gadoteridol
1865:Gadodiamide
1802:Iofendylate
1788:, lipiodol)
1786:fatty acids
1784:of iodised
1640:Metrizamide
1632:low osmolar
720:: 749–760.
688:10665/44053
513:myelography
482:fatty acids
282:Iodized oil
269:100.122.502
180:Identifiers
44:Other names
35:Trade names
23:Iodized oil
1983:Ultrasound
1969:Perflubron
1949:Iron oxide
1944:Ferristene
1939:Ferumoxsil
1875:Gadolinium
1860:Gadobutrol
1769:Iodinated,
1726:Adipiodone
1690:Iobitridol
1555:Iodinated,
555:References
520:was born.
511:(used for
412:iodine-131
396:emulsified
304:, it is a
231:KZW0R0686Q
206:ChemSpider
186:CAS Number
2051:Phase III
2039:Withdrawn
2004:galactose
1680:Iodixanol
1660:Iopromide
1655:Iopamidol
1615:Methiodal
1129:231788293
468:Chemistry
302:injection
195:8008-53-5
101:Routes of
57:Drugs.com
2094:Category
2084:Medicine
1685:Iomeprol
1675:Iopentol
1670:Ioversol
1665:Iotrolan
1585:Iodamide
1474:21277801
1439:45475444
1317:11204500
1295:Medicine
1273:12762640
1227:33053612
1178:34568220
1121:33529007
1101:ACS Nano
1085:22169503
1049:21664971
1014:12719852
1006:26390875
971:25322807
963:16053340
925:10857165
884:40066693
876:16724976
823:(2019).
807:11640460
654:11951214
619:12735133
547:, until
325:embolism
290:Lipiodol
113:ATC code
85:DailyMed
1792:Iopydol
1695:Ioxilan
1645:Iohexol
1620:Diodone
1431:9504541
1388:9388412
1218:9508794
1169:8460342
1029:Methods
545:Guerbet
500:History
401:embolic
352:Imaging
170:WARNING
134: (
123: (
121:V08AD01
87::
2070:Portal
2034:WHO-EM
1472:
1437:
1429:
1411:Lancet
1394:
1386:
1368:Lancet
1346:
1315:
1271:
1225:
1215:
1176:
1166:
1127:
1119:
1083:
1047:
1012:
1004:
969:
961:
923:
913:
882:
874:
805:
732:
695:
652:
617:
582:22 Oct
474:iodine
298:iodine
242:ChEMBL
167:
83:
1962:Other
1912:Other
1435:S2CID
1396:93815
1392:S2CID
1125:S2CID
1010:S2CID
967:S2CID
880:S2CID
132:H03CA
1470:PMID
1427:PMID
1384:PMID
1344:ISBN
1313:PMID
1269:PMID
1223:PMID
1201:2020
1174:PMID
1117:PMID
1081:PMID
1045:PMID
1002:PMID
959:PMID
921:PMID
911:ISBN
872:PMID
803:PMID
730:ISBN
693:ISBN
650:PMID
615:PMID
584:2023
296:and
222:UNII
213:none
53:AHFS
2002:of
1993:of
1832:MRI
1780:(=
1538:V08
1462:doi
1419:doi
1415:351
1376:doi
1372:350
1336:doi
1303:doi
1213:PMC
1205:doi
1164:PMC
1156:doi
1109:doi
1073:doi
1037:doi
994:doi
951:doi
903:doi
862:doi
829:hdl
795:doi
722:doi
683:hdl
642:doi
607:doi
577:FDA
484:of
480:of
137:WHO
126:WHO
2096::
2047::
1951:,
1914::
1853::
1494:.
1468:.
1458:22
1456:.
1433:.
1425:.
1413:.
1390:.
1382:.
1370:.
1358:^
1342:.
1311:.
1299:80
1297:.
1293:.
1281:^
1265:26
1263:.
1243:.
1221:.
1211:.
1199:.
1195:.
1172:.
1162:.
1152:10
1150:.
1146:.
1123:.
1115:.
1105:15
1103:.
1079:.
1069:38
1067:.
1043:.
1033:55
1031:.
1008:.
1000:.
990:39
988:.
965:.
957:.
945:.
933:^
919:.
909:.
878:.
870:.
858:21
856:.
852:.
801:.
791:42
765:^
755:.
744:^
728:.
718:34
716:.
691:.
662:^
648:.
638:29
636:.
613:.
603:12
601:.
575:.
571:.
430:.
371:.
320:.
163:US
80:US
2072::
1540:)
1536:(
1526:e
1519:t
1512:v
1476:.
1464::
1441:.
1421::
1398:.
1378::
1352:.
1338::
1319:.
1305::
1275:.
1247:.
1229:.
1207::
1180:.
1158::
1131:.
1111::
1087:.
1075::
1051:.
1039::
1016:.
996::
973:.
953::
947:4
927:.
905::
886:.
864::
831::
809:.
797::
759:.
738:.
724::
701:.
685::
656:.
644::
621:.
609::
586:.
406:"
165::
55:/
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