1828:, treatment of cancer patients with PEG-rHuIL-10 elicits a dose titratable induction of the immune stimulatory cytokines IFNγ, IL-18, IL-7, GM-CSF and IL-4. Furthermore, treated patients exhibit fold increases of peripheral CD8+ T cells expressing markers of activation, such as programmed death 1 (PD1)+, lymphocyte activation gene 3 (LAG3)+ and increased Fas Ligand (FasL) and a decrease in serum TGFβ. These findings are consistent with the published preclinical immunoncology reports using PEG-rMuIL-10 and with previous findings treating humans with rHuIL-10. These data suggest that while IL-10 can exert immunosuppressive effects in context of bacterial product stimulated myeloid cells, rHuIL-10/PEG-rHuIL-10 treatment of humans is predominantly immunostimulatory. As of 2018 AM0010 (aka
328:
305:
5036:
1671:
Expression of IL-10 from transfected tumor cell lines in IL-10 transgenic mice or dosing with IL-10 leads to control of primary tumor growth and decreased metastatic burden. More recently, PEGylated recombinant murine IL-10 (PEG-rMuIL-10) has been shown to induce IFNγ and CD8+ T cell dependent anti-tumor immunity. More specifically, PEGylated recombinant human IL-10 (PEG-rHuIL-10) has been shown to enhance CD8+ T cell secretion of the cytotoxic molecules
Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion.
227:
202:
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5126:
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31:
5171:
5081:
334:
233:
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1807:
treatment initially exhibited promising clinical data in psoriasis, but failed to achieve clinical significance in a randomized, double blind, placebo controlled Phase II trial. Further investigation of rHuIL-10's effects in humans suggests that rather than inhibiting inflammation, rHuIL-10 is capable of exerting pro-inflammatory effects.
579:
1653:
Discovered in 1991, IL-10 was initially reported to suppress cytokine secretion, antigen presentation and CD4+ T cell activation. Further investigation has shown that IL-10 predominantly inhibits lipopolysaccharide (LPS) and bacterial product mediated induction of the pro-inflammatory cytokines TNFα,
1806:
Due to the data, thousands of patients with a variety of autoimmune diseases were treated with recombinant human IL-10 (rHuIL-10) in clinical trials. Contrary to expectations, rHuIL-10 treatment did not significantly impact disease in patients with Crohn's disease or rheumatoid arthritis. rHuIL-10
1670:
Over time a more nuanced picture of IL-10's function has emerged as treatment of tumor bearing mice has been shown to inhibit tumor metastasis. Additional investigation by multiple laboratories has generated data that further supports IL-10's immunostimulatory capacity in an immunoncology context.
1718:
IL-10 checks the inducible form of Cyclo-oxygenase, Cyclo-oxygenase-2 (COX-2). Lack of IL-10 has been shown to cause COX activation and resultant
Thromboxane receptor activation to cause vascular endothelial and cardiac dysfunctions in mice. Interleukin 10 knockout frail mice develop cardiac and
1741:
levels are not regulated effectively as IL-10 regulates the TNF-α-converting enzyme. As a result, TNFα levels rise and result in inflammation. TNFα itself induces demyelination of the oligodendroglial via TNF receptor 1, while chronic inflammation has been linked to demyelination of neurons.
1573:
receptors. The expression of IL-10 is minimal in unstimulated tissues and seems to require triggering by commensal or pathogenic flora. IL-10 expression is tightly regulated at the transcriptional and post-transcriptional level. Extensive IL-10 locus remodeling is observed in monocytes upon
3941:
Fedorak RN, Gangl A, Elson CO, Rutgeerts P, Schreiber S, Wild G, et al. (December 2000). "Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The
Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group".
57:
1714:
and Th1 T cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells; however, it is also stimulatory towards certain T cells (Th2) and mast cells and stimulates B cell maturation and antibody production.
4052:
van Roon J, Wijngaarden S, Lafeber FP, Damen C, van de Winkel J, Bijlsma JW (April 2003). "Interleukin 10 treatment of patients with rheumatoid arthritis enhances Fc gamma receptor expression on monocytes and responsiveness to immune complex stimulation".
3977:
Schreiber S, Fedorak RN, Nielsen OH, Wild G, Williams CN, Nikolaus S, et al. (December 2000). "Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn's disease. Crohn's
Disease IL-10 Cooperative Study Group".
2715:"Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression"
1783:
A recent mouse study indicates that IL-10 regulates CD36, a key phagocytosis effector, promoting hematoma clearance after intracerebral hemorrhage. IL-10 deficiency aggravates traumatic brain injury in male but not female mice.
3756:
Ezzeddini R, Somi MH, Taghikhani M, Moaddab SY, Masnadi
Shirazi K, Shirmohammadi M, et al. (February 2021). "Association of Foxp3 rs3761548 polymorphism with cytokines concentration in gastric adenocarcinoma patients".
1819:
recombinant human IL-10 (PEG-rHuIL-10, AM0010). Consistent with preclinical immunoncology data, investigators report substantial anti-tumor efficacy. Contrary to the reported immunosuppressive effects of IL-10 generated
3224:
Berman RM, Suzuki T, Tahara H, Robbins PD, Narula SK, Lotze MT (July 1996). "Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice".
341:
240:
4014:
5035:
1602:
stimulation of the IL-10 receptor and inhibition of the p38 signaling pathway. Additionally, IL-10 expression is extensively regulated at the post-transcriptional level, which may involve control of
3391:
Grimbaldeston MA, Nakae S, Kalesnikoff J, Tsai M, Galli SJ (October 2007). "Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B".
3356:
Chan IH, Wu V, Bilardello M, Mar E, Oft M, Van
Vlasselaer P, et al. (December 2015). "The Potentiation of IFN-γ and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells".
1851:
The receptor complex for IL-10 also requires the IL10R2 chain to initiate signalling. This ligand–receptor combination is found in birds and frogs, and is also likely to exist in bony fish.
3703:
Serrano AE, Menares-Castillo E, Garrido-Tapia M, Ribeiro CH, Hernández CJ, Mendoza-Naranjo A, et al. (March 2011). "Interleukin 10 decreases MICA expression on melanoma cell surface".
3906:
Braat H, Rottiers P, Hommes DW, Huyghebaert N, Remaut E, Remon JP, et al. (June 2006). "A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease".
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Asadullah K, Döcke WD, Ebeling M, Friedrich M, Belbe G, Audring H, et al. (February 1999). "Interleukin 10 treatment of psoriasis: clinical results of a phase 2 trial".
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4447:
Josephson K, McPherson DT, Walter MR (December 2001). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1".
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4580:
Zhu H, Wang Z, Yu J, Yang X, He F, Liu Z, et al. (July 2019). "Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage".
3091:
Sun H, Gutierrez P, Jackson MJ, Kundu N, Fulton AM (2000-04-01). "Essential role of nitric oxide and interferon-gamma for tumor immunotherapy with interleukin-10".
2767:"A molecular basis for T cell suppression by IL-10: CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding"
6942:
4683:
Beebe AM, Cua DJ, de Waal
Malefyt R (2003). "The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS)".
3577:"Multiple sclerosis: levels of interleukin-10-secreting blood mononuclear cells are low in untreated patients but augmented during interferon-beta-1b treatment"
4977:
4117:"Clinical and immunologic assessment of patients with psoriasis in a randomized, double-blind, placebo-controlled trial using recombinant human interleukin 10"
2863:
Opp MR, Smith EM, Hughes TK (July 1995). "Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep".
3849:
Gu Y, Dong Y, Wan J, Ren H, Koehler RC, Wang J (September 2022). "Interleukin-10 deficiency aggravates traumatic brain injury in male but not female mice".
4828:
Asadullah K, Sabat R, Friedrich M, Volk HD, Sterry W (June 2004). "Interleukin-10: an important immunoregulatory cytokine with major impact on psoriasis".
6452:
1122:
7564:
5110:
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1103:
7338:
163:
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6477:
5715:
5170:
5080:
1799:
react favorably towards treatment with recombinant interleukin-10-producing bacteria, demonstrating the importance of IL-10 for counteracting the
6896:
6691:
3483:
Ostrowski K, Schjerling P, Pedersen BK (December 2000). "Physical activity and plasma interleukin-6 in humans--effect of intensity of exercise".
7208:
7203:
7188:
7100:
7079:
6528:
6462:
6421:
6319:
5787:
1927:
1909:
1795:
studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. and, indeed, patients with
7069:
6937:
6844:
6823:
6574:
6543:
6538:
6482:
6401:
3660:
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1948:
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3052:"Interleukin-10 gene transfer activates interferon-gamma and the interferon-gamma-inducible genes Gbp-1/Mag-1 and Mig-1 in mammary tumors"
7115:
6548:
6376:
6371:
2909:
Aste-Amezaga M, Ma X, Sartori A, Trinchieri G (June 1998). "Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10".
3068:
3051:
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6386:
1322:
1329:
6312:
4492:"Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization"
7035:
7031:
7027:
5791:
3892:
1815:
Further to these data, a Phase I immunoncology clinical trial is currently being conducted to assess the therapeutic capacity of
3273:"IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs"
2835:
2818:
2045:"Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma"
7524:
6791:
6186:
1845:
1408:
7528:
7514:
7474:
5044:: INTERLEUKIN-10 CRYSTAL STRUCTURE REVEALS THE FUNCTIONAL DIMER WITH AN UNEXPECTED TOPOLOGICAL SIMILARITY TO INTERFERON GAMMA
5015:
2663:"Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes"
1591:
1412:
3618:"Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism"
1892:
7589:
7543:
54:
4894:"Alternative activation-skewed microglia/macrophages promote hematoma resolution in experimental intracerebral hemorrhage"
4205:"Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma"
5211:
2133:
Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB (2004). "Interleukin-10 and related cytokines and receptors".
1871:
4859:"IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly"
7448:
4537:"Viral and murine interleukin-10 are correctly processed and retain their biological activity when produced in tobacco"
2170:"Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection"
6396:
6077:
327:
2626:
Moore KW, de Waal
Malefyt R, Coffman RL, O'Garra A (2001-01-01). "Interleukin-10 and the interleukin-10 receptor".
3802:"Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating CD36"
2520:"Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family"
2323:"IL-35 is a novel responsive anti-inflammatory cytokine--a new system of categorizing anti-inflammatory cytokines"
5607:
4015:"Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group"
1896:
1875:
1415:
proteins. Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces
304:
1594:
and NF-κB signalling and transcriptional activation via promoter binding of the transcription factors NF-κB and
5095:
4741:
Roncarolo MG, Battaglia M, Gregori S (June 2003). "The role of interleukin 10 in the control of autoimmunity".
4261:"A first-in-human dose escalation study of PEGylated recombinant human IL-10 (AM0010) in advanced solid tumors"
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Malefyt R, Coffman RL, O'Garra A (2001). "Interleukin-10 and the interleukin-10 receptor".
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1148:
5065:
226:
201:
143:
6220:
5770:
5545:
2479:"Posttranscriptional regulation of IL-10 gene expression through sequences in the 3'-untranslated region"
1841:
1738:
1703:
6253:
6055:
5765:
4857:
Stenvinkel P, Ketteler M, Johnson RJ, Lindholm B, Pecoits-Filho R, Riella M, et al. (April 2005).
4799:
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4294:
Early Data Supports Phase 3 Trial of Pegilodecakin as Possible Treatment for Advanced Pancreatic Cancer
3136:"A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells"
1726:, as exercise provokes an increase in circulating levels of IL-1ra, IL-10, and sTNF-R, suggesting that
1647:
1566:
1416:
340:
239:
5149:: Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain
2713:
de Waal Malefyt R, Haanen J, Spits H, Roncarolo MG, te Velde A, Figdor C, et al. (October 1991).
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1615:
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1772:
through influencing Tregs function and the secretion of immunomodulatory cytokines such as IL-10,
7367:
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7306:
7250:
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7177:
7135:
7089:
7008:
6982:
6926:
6885:
6859:
6833:
6487:
5204:
2954:"Cellular mechanisms that cause suppressed gamma interferon secretion in endotoxin-tolerant mice"
1558:
1420:
5050:
3436:"Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age"
2952:
Varma TK, Toliver-Kinsky TE, Lin CY, Koutrouvelis AP, Nichols JE, Sherwood ER (September 2001).
1305:
1284:
1258:
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5537:
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4935:
Copeland KF (December 2005). "Modulation of HIV-1 transcription by cytokines and chemokines".
3185:"Interleukin-10 promotes the maintenance of antitumor CD8(+) T-cell effector function in situ"
7594:
4535:
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3575:
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2436:
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2146:
1642:. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block
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6063:
5001:
4456:
4319:
4259:
Infante JR, Naing A, Papadopoulos KP, Autio KA, Ott PA, Wong DJ, et al. (2015-05-20).
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2383:
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5134:: Crystal structure of Epstein-Barr virus IL-10 complexed with the soluble IL-10R1 chain
4460:
4323:
2584:
2438:"Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10"
2338:
6365:
6338:
6072:
6029:
5944:
5651:
5197:
4918:
4893:
4671:
4605:
4563:
4536:
4408:"Characterization of recombinant extracellular domain of human interleukin-10 receptor"
4367:"Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site"
4229:
4204:
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3826:
3801:
3782:
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2020:
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4913:
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4870:
4837:
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4721:
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4626:
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4026:
3987:
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3712:
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3284:
3234:
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3001:
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2973:
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2726:
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2598:
2588:
2539:
2531:
2490:
2449:
2422:
2400:
2392:
2352:
2342:
2293:
2283:
2238:
2230:
2219:"The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion"
2189:
2181:
2142:
2105:
2097:
2056:
2015:
2007:
1957:
1691:
1630:, effects in immunoregulation and inflammation. It downregulates the expression of
420:
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295:
250:
6304:
3315:
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3289:
3272:
155:
7351:
5775:
5461:
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2922:
2347:
2101:
1607:
395:
179:
4177:
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3451:
3152:
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1683:, counteracting the inflammatory effect that these cells have at the site of an
1598:. IL-10 may autoregulate its expression via a negative feed-back loop involving
7549:
7539:
7534:
7520:
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7496:
7491:
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7420:
7399:
7378:
7357:
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7019:
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6112:
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4312:
Proceedings of the National Academy of Sciences of the United States of America
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3238:
2573:
Proceedings of the National Academy of Sciences of the United States of America
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1690:
IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as
1603:
1463:
1459:
1455:
1451:
1447:
1424:
496:
4909:
4468:
3919:
3817:
3673:
3333:
3316:
2234:
1760:) as a transcription factor is an essential molecular marker of regulatory T (
7583:
7291:
6947:
6813:
6772:
6696:
6630:
6579:
6533:
6472:
6357:
6279:
6274:
6269:
6215:
6164:
5830:
5734:
5710:
5705:
5682:
5677:
5668:
5659:
5441:
4841:
4646:
Girndt M (2003). "Humoral immune responses in uremia and the role of IL-10".
4490:
Hoover DM, Schalk-Hihi C, Chou CC, Menon S, Wlodawer A, Zdanov A (May 1999).
4424:
4407:
4332:
3528:"Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans"
3201:
3184:
2569:"Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a"
2288:
1829:
1792:
1699:
1695:
1631:
1527:
1436:
607:
30:
5189:
3991:
3955:
2593:
556:
434:
7465:
7286:
6972:
6967:
6962:
6711:
6650:
6609:
5760:
5592:
5119:: Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain
4956:
4927:
4884:
4849:
4820:
4791:
4762:
4733:
4704:
4667:
4638:
4601:
4572:
4553:
4517:
4476:
4392:
4238:
4186:
4142:
4101:
4066:
3999:
3963:
3927:
3870:
3835:
3778:
3734:
3702:
3681:
3643:
3602:
3504:
3469:
3412:
3377:
3342:
3298:
3210:
3112:
3069:
10.1002/(sici)1097-0215(19990209)80:4<624::aid-ijc23>3.0.co;2-9
2987:
2844:
2792:
2678:
2647:
2612:
2553:
2504:
2463:
2414:
2366:
2307:
2252:
2203:
2154:
2119:
2029:
1800:
1635:
1397:
998:
positive regulation of vascular associated smooth muscle cell proliferation
993:
negative regulation of vascular associated smooth muscle cell proliferation
413:
192:
4433:
4351:
4038:
3634:
3617:
3561:
3496:
3369:
3246:
3161:
3077:
3036:
3018:
2930:
2884:
2783:
2766:
2748:
2730:
2696:
2535:
2454:
2437:
2070:
1969:
1961:
1369:
1364:
678:
negative regulation of chronic inflammatory response to antigenic stimulus
7296:
7276:
7239:
7074:
7064:
6916:
6911:
6746:
6716:
6655:
6497:
6457:
6416:
6411:
6181:
6127:
5868:
5627:
5550:
4220:
3716:
1737:
when compared to healthy individuals. Due to a decrease in IL-10 levels,
1711:
1627:
1579:
1212:
1193:
3800:
Li Q, Lan X, Han X, Durham F, Wan J, Weiland A, et al. (May 2021).
3725:
3526:
Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK (February 1999).
1446:
IL-10 is classified as a class-2 cytokine, a set of cytokines including
578:
7281:
7271:
7166:
7059:
7054:
6875:
6736:
6726:
6660:
6594:
6507:
6502:
6431:
6234:
5927:
5617:
5577:
5179:: CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-10 AT 1.6 ANGSTROMS RESOLUTION
5089:: ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT
2836:
10.1002/1521-4141(200006)30:6<1683::AID-IMMU1683>3.0.CO;2-A
2518:
Schulte LN, Eulalio A, Mollenkopf HJ, Reinhardt R, Vogel J (May 2011).
2321:
Li X, Mai J, Virtue A, Yin Y, Gong R, Sha X, et al. (March 2012).
1733:
Lower levels of IL-10 have been observed in individuals diagnosed with
1639:
1523:
1440:
312:
209:
159:
4659:
4616:
2625:
2405:
1768:
polymorphism (rs3761548) might be involved in cancer progression like
763:
negative regulation of cytokine production involved in immune response
100:
96:
92:
88:
84:
80:
76:
6751:
6741:
6731:
6604:
5239:
1816:
1680:
1599:
1535:
1471:
1067:
379:
366:
278:
265:
167:
2396:
2217:
Ağaç D, Estrada LD, Maples R, Hooper LV, Farrar JD (November 2018).
2185:
6391:
6229:
5224:
4306:
Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (December 1993).
3404:
2712:
1746:
1611:
1519:
1423:
of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by
1400:
1353:
1028:
positive regulation of pri-miRNA transcription by RNA polymerase II
4892:
Chang CF, Wan J, Li Q, Renfroe SC, Heller NM, Wang J (July 2017).
4308:"A receptor for interleukin 10 is related to interferon receptors"
4202:
2951:
2660:
1777:
1643:
1561:
triggering in these cells. IL-10 upregulation is also mediated by
7510:
6993:
4856:
3390:
2517:
2266:
Saroz Y, Kho DT, Glass M, Graham ES, Grimsey NL (December 2019).
1723:
1407:
gene. IL-10 signals through a receptor complex consisting of two
1179:
1134:
1052:
1048:
2477:
Powell MJ, Thompson SA, Tone Y, Waldmann H, Tone M (July 2000).
753:
positive regulation of DNA-binding transcription factor activity
713:
negative regulation of chemokine (C-C motif) ligand 5 production
147:
7125:
6107:
6004:
5999:
5994:
5989:
5984:
5979:
5697:
5502:
5486:
5481:
5476:
5471:
5466:
5456:
5451:
4972:
4051:
2908:
2765:
Akdis CA, Joss A, Akdis M, Faith A, Blaser K (September 2000).
2086:"Interferon-λ: Immune Functions at Barrier Surfaces and Beyond"
2042:
1707:
1554:
1550:
1337:
1089:
587:
4993:
4079:
3905:
3755:
1023:
positive regulation of receptor signaling pathway via JAK-STAT
888:
negative regulation of membrane protein ectodomain proteolysis
7432:
7428:
7424:
7043:
7039:
7023:
6143:
6102:
6097:
6092:
6087:
6082:
6019:
6009:
5974:
5969:
5964:
5959:
5954:
5949:
5602:
5597:
5587:
5572:
5567:
5446:
5436:
5431:
5426:
5416:
5411:
5405:
5389:
5379:
5374:
5369:
5364:
5359:
5354:
5349:
5344:
5338:
5333:
5328:
5323:
5318:
5313:
5308:
5303:
4449:
Acta Crystallographica. Section D, Biological Crystallography
4258:
1773:
1765:
1757:
1750:
1562:
1495:
1491:
1483:
1033:
negative regulation of hydrogen peroxide-induced neuron death
3615:
6067:
6014:
5582:
5523:
5518:
5298:
5293:
5288:
5283:
5277:
5271:
5265:
5259:
5254:
4827:
4711:
4534:
4161:"Proinflammatory effects of IL-10 during human endotoxemia"
3976:
3525:
3482:
1761:
1587:
1583:
1542:
1515:
4489:
3940:
3574:
2817:
Joss A, Akdis M, Faith A, Blaser K, Akdis CA (June 2000).
2476:
2435:
7500:
4740:
4114:
3223:
1947:
1679:
A study in mice has shown that IL-10 is also produced by
1539:
918:
positive regulation of transcription by RNA polymerase II
688:
negative regulation of endothelial cell apoptotic process
4446:
4012:
3433:
3317:"IL-10 elicits IFNγ-dependent tumor immune surveillance"
3183:
Fujii S, Shimizu K, Shimizu T, Lotze MT (October 2001).
3182:
3133:
3090:
2566:
2132:
843:
negative regulation of nitric oxide biosynthetic process
813:
negative regulation of myeloid dendritic cell activation
783:
negative regulation of MHC class II biosynthetic process
683:
positive regulation of MHC class II biosynthetic process
403:
4682:
3659:
3050:
Sun H, Jackson MJ, Kundu N, Fulton AM (February 1999).
2216:
2167:
1730:
fosters an environment of anti-inflammatory cytokines.
883:
negative regulation of tumor necrosis factor production
4364:
4158:
3270:
1749:
cell lines, IL-10 modulates the surface expression of
848:
branching involved in labyrinthine layer morphogenesis
733:
cellular response to hepatocyte growth factor stimulus
4798:
4405:
4013:
van Deventer SJ, Elson CO, Fedorak RN (August 1997).
3314:
3049:
3000:
1996:"Interleukin-10: new perspectives on an old cytokine"
968:
positive regulation of heterotypic cell-cell adhesion
963:
negative regulation of heterotypic cell-cell adhesion
953:
positive regulation of endothelial cell proliferation
568:
2904:
2902:
2816:
958:
negative regulation of cell population proliferation
6334:
3355:
2764:
2265:
1646:activity, and is involved in the regulation of the
1008:
positive regulation of transcription, DNA-templated
2382:
1888:
1886:
1884:
1867:
1865:
1863:
698:negative regulation of interferon-gamma production
4891:
2899:
2083:
933:negative regulation of sensory perception of pain
350:
249:
134:, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10
7581:
4365:Josephson K, Logsdon NJ, Walter MR (July 2001).
3655:
3653:
3266:
3264:
923:negative regulation of interleukin-12 production
778:negative regulation of interleukin-18 production
4254:
4252:
4250:
4248:
2708:
2706:
2378:
2376:
1881:
1860:
858:regulation of complement-dependent cytotoxicity
823:negative regulation of interleukin-8 production
743:negative regulation of interleukin-6 production
728:negative regulation of interleukin-1 production
708:positive regulation of B cell apoptotic process
4830:Current Drug Targets. Inflammation and Allergy
3799:
2862:
2320:
1893:GRCm38: Ensembl release 89: ENSMUSG00000016529
1403:. In humans, interleukin 10 is encoded by the
6320:
5219:
5205:
5009:
4579:
3650:
3358:Journal of Interferon & Cytokine Research
3261:
2760:
2758:
2654:
1989:
1987:
1943:
1941:
1430:
1038:positive regulation of sprouting angiogenesis
4769:
4483:
4440:
4358:
4305:
4245:
4198:
4196:
4154:
4152:
3899:
3848:
3842:
3793:
3662:Clinical Reviews in Allergy & Immunology
3609:
3568:
3476:
3427:
3384:
3310:
3308:
2812:
2810:
2703:
2560:
2511:
2470:
2429:
2373:
2314:
2276:ACS Pharmacology & Translational Science
2161:
2084:Lazear HM, Nice TJ, Diamond MS (July 2015).
938:positive regulation of macrophage activation
908:negative regulation of inflammatory response
4399:
4299:
3519:
2858:
2856:
2854:
2126:
2077:
1993:
1872:GRCh38: Ensembl release 89: ENSG00000136634
1501:
903:negative regulation of B cell proliferation
838:negative regulation of T cell proliferation
6327:
6313:
5212:
5198:
5016:
5002:
2755:
2036:
1984:
1938:
1638:antigens, and co-stimulatory molecules on
1557:. IL-10 can be produced by monocytes upon
1390:human cytokine synthesis inhibitory factor
913:negative regulation of cytokine production
4986:at the U.S. National Library of Medicine
4917:
4874:
4562:
4552:
4507:
4423:
4382:
4341:
4331:
4228:
4193:
4176:
4149:
4132:
3825:
3724:
3633:
3592:
3551:
3459:
3332:
3305:
3288:
3200:
3151:
3067:
3026:
2977:
2834:
2807:
2782:
2738:
2686:
2602:
2592:
2543:
2494:
2453:
2404:
2356:
2346:
2297:
2287:
2242:
2193:
2109:
2060:
2019:
1787:
1719:vascular dysfunction with increased age.
1003:interleukin-12-mediated signaling pathway
978:negative regulation of mitotic cell cycle
7492:Interleukin 14 (taxilin alpha, HMW-BCGF)
4934:
3908:Clinical Gastroenterology and Hepatology
2851:
2147:10.1146/annurev.immunol.22.012703.104622
758:negative regulation of apoptotic process
723:negative regulation of cytokine activity
703:regulation of sensory perception of pain
1549:, and in a certain subset of activated
898:cellular response to lipopolysaccharide
738:cellular response to estradiol stimulus
7582:
6790:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
4645:
3485:European Journal of Applied Physiology
1846:Interleukin 10 receptor, alpha subunit
1654:IL-1β, IL-12, and IFNγ secretion from
6308:
5193:
4997:
4978:Interferons or interleukin-10 (IL-10)
1756:In addition, Forkhead box protein 3 (
773:cytoplasmic sequestering of NF-kappaB
355:
316:
311:
254:
213:
208:
4685:Cytokine & Growth Factor Reviews
3007:The Journal of Experimental Medicine
2719:The Journal of Experimental Medicine
2667:The Journal of Experimental Medicine
1994:Mosser DM, Zhang X (December 2008).
1474:, -beta, -epsilon, -kappa, -omega),
5104:: STRUCTURE OF VIRAL INTERLEUKIN-10
4937:Mini Reviews in Medicinal Chemistry
4412:The Journal of Biological Chemistry
1665:
1626:IL-10 is a cytokine with multiple,
1582:pathways. IL-10 induction involves
1506:In humans, IL-10 is encoded by the
1018:cytokine-mediated signaling pathway
13:
5164:: Crystal structure of human IL-10
4527:
3893:"Entrez Gene: IL10 interleukin 10"
3581:Scandinavian Journal of Immunology
1810:
1674:
988:regulation of response to wounding
983:endothelial cell apoptotic process
948:regulation of synapse organization
14:
7606:
4965:
1832:) is in phase 3 clinical trials.
973:positive regulation of cell cycle
5169:
5154:
5139:
5124:
5109:
5094:
5079:
5064:
5049:
5034:
4971:
4876:10.1111/j.1523-1755.2005.00200.x
4631:10.1146/annurev.immunol.19.1.683
4509:10.1046/j.1432-1327.1999.00363.x
4496:European Journal of Biochemistry
4271:(15_suppl): 3017. Archived from
4031:10.1053/gast.1997.v113.pm9247454
3594:10.1046/j.1365-3083.1999.00546.x
3544:10.1111/j.1469-7793.1999.287ad.x
3105:10.1097/00002371-200003000-00005
2640:10.1146/annurev.immunol.19.1.683
2012:10.1111/j.1600-065X.2008.00706.x
1013:negative regulation of autophagy
577:
515:lumbar subsegment of spinal cord
339:
332:
326:
303:
238:
231:
225:
200:
29:
7318:Interleukin 27 (interleukin 30)
5074:: HUMAN IL-10 / IL-10R1 COMPLEX
5023:
4594:10.1016/j.pneurobio.2019.03.003
4286:
4108:
4073:
4045:
4006:
3970:
3934:
3885:
3863:10.1016/j.expneurol.2022.114125
3749:
3696:
3349:
3217:
3176:
3127:
3084:
3056:International Journal of Cancer
3043:
2994:
2970:10.1128/iai.69.9.5249-5263.2001
2945:
2619:
2259:
2210:
1835:
1518:, and is primarily produced by
878:regulation of isotype switching
636:interleukin-10 receptor binding
3622:European Journal of Immunology
2823:European Journal of Immunology
2442:European Journal of Immunology
1920:
1902:
1439:; each of its subunits is 178-
828:response to lipopolysaccharide
588:More reference expression data
557:More reference expression data
1:
4813:10.1016/S0896-8411(03)00043-X
4784:10.1016/S0896-8411(03)00044-1
4755:10.1016/S0896-8411(03)00047-7
4726:10.1016/S1471-4906(02)00009-1
4697:10.1016/S1359-6101(02)00025-4
4384:10.1016/S1074-7613(01)00169-8
3806:Brain, Behavior, and Immunity
3290:10.1158/0008-5472.CAN-12-0721
2223:Brain, Behavior, and Immunity
2062:10.1016/S0969-2126(01)00193-9
1854:
928:defense response to protozoan
868:regulation of gene expression
853:defense response to bacterium
793:response to organic substance
641:protein dimerization activity
324:
223:
4134:10.1001/archderm.138.10.1341
2923:10.4049/jimmunol.160.12.5936
2877:10.1016/0165-5728(95)00066-b
2348:10.1371/journal.pone.0033628
2102:10.1016/j.immuni.2015.07.001
7:
7590:Genes on human chromosome 1
6668:Antisense oligonucleotides:
4619:Annual Review of Immunology
4178:10.4049/jimmunol.165.5.2783
4055:The Journal of Rheumatology
3705:Immunology and Cell Biology
3452:10.1016/j.exger.2012.11.001
3153:10.4049/jimmunol.162.3.1723
2628:Annual Review of Immunology
2268:"Cannabinoid Receptor 2 (CB
2135:Annual Review of Immunology
1801:hyperactive immune response
1621:
798:response to carbon monoxide
10:
7613:
4949:10.2174/138955705774933383
4094:10.1001/archderm.135.2.187
3771:10.1016/j.cyto.2020.155351
3239:10.4049/jimmunol.157.1.231
2865:Journal of Neuroimmunology
2496:10.4049/jimmunol.165.1.292
2385:Nature Reviews. Immunology
1648:JAK-STAT signaling pathway
1510:gene, which is located on
1431:Gene and protein structure
768:response to glucocorticoid
16:Anti-inflammatory cytokine
7484:
7464:
7457:
7408:
7387:
7366:
7326:
7305:
7249:
7217:
7176:
7134:
7088:
7007:
6981:
6925:
6884:
6858:
6832:
6801:
6781:
6760:
6679:
6618:
6562:
6516:
6440:
6345:
6199:
6175:Colony-stimulating factor
6157:
6126:
6054:
6028:
5935:
5926:
5867:
5858:
5823:
5786:
5724:
5696:
5650:
5635:
5626:
5536:
5511:
5495:
5398:
5247:
5238:
5231:
5029:
4910:10.1016/j.nbd.2017.03.016
4469:10.1107/S0907444901016249
3920:10.1016/j.cgh.2006.03.028
3818:10.1016/j.bbi.2021.02.001
3674:10.1007/s12016-011-8287-6
3532:The Journal of Physiology
3334:10.1016/j.ccr.2011.11.003
2235:10.1016/j.bbi.2018.09.004
1928:"Mouse PubMed Reference:"
1910:"Human PubMed Reference:"
1522:and, to a lesser extent,
1368:
1363:
1359:
1352:
1336:
1330:Chr 1: 130.95 – 130.95 Mb
1323:Chr 1: 206.77 – 206.77 Mb
1317:
1302:
1298:
1281:
1277:
1270:
1255:
1251:
1234:
1230:
1223:
1210:
1206:
1191:
1187:
1178:
1165:
1161:
1146:
1142:
1133:
1120:
1116:
1101:
1097:
1088:
1073:
1066:
1062:
1046:
606:
602:
585:
576:
567:
554:
503:
494:
441:
432:
402:
394:
390:
373:
360:
323:
302:
293:
289:
272:
259:
222:
199:
190:
186:
141:
138:
128:
121:
116:
73:
68:
51:
46:
41:
37:
28:
23:
6210:proinflammatory cytokine
4988:Medical Subject Headings
4842:10.2174/1568010043343886
4582:Progress in Neurobiology
4425:10.1074/jbc.270.21.12906
4333:10.1073/pnas.90.23.11267
3440:Experimental Gerontology
3202:10.1182/blood.v98.7.2143
3093:Journal of Immunotherapy
2289:10.1021/acsptsci.9b00049
1840:IL-10 has been shown to
1502:Expression and synthesis
7358:Interleukin-29 (IFN-λ1)
6503:Daclizumab (dacliximab)
6488:Tucotuzumab celmoleukin
4898:Neurobiology of Disease
4801:Journal of Autoimmunity
4772:Journal of Autoimmunity
4743:Journal of Autoimmunity
4121:Archives of Dermatology
4082:Archives of Dermatology
3992:10.1053/gast.2000.20196
3956:10.1053/gast.2000.20229
2594:10.1073/pnas.0808743106
1722:IL-10 is linked to the
1482:(IFN-lambda, including
1435:The IL-10 protein is a
1427:and Tyk2 respectively.
7339:Interferon λ4 (IFN-λ4)
6432:Rilonacept (IL-1 Trap)
5341:/PARC/DCCK1/AMAC1/MIP4
4554:10.1186/1472-6750-9-22
4265:ASCO Meeting Abstracts
3851:Experimental Neurology
2958:Infection and Immunity
2679:10.1084/jem.174.5.1209
1788:Clinical use or trials
1710:made by cells such as
873:B cell differentiation
808:type 2 immune response
718:response to inactivity
626:growth factor activity
531:lumbar spinal ganglion
7262:Interleukin 23 (SGRF)
6943:Cintredekin besudotox
6871:Interleukin 11 (AGIF)
6850:Interleukin 10 (CSIF)
4165:Journal of Immunology
3635:10.1002/eji.200737821
3497:10.1007/s004210000312
3370:10.1089/jir.2014.0221
3227:Journal of Immunology
3140:Journal of Immunology
3019:10.1084/jem.184.2.579
2911:Journal of Immunology
2784:10.1096/fj.99-0874fje
2731:10.1084/jem.174.4.915
2536:10.1038/emboj.2011.94
2483:Journal of Immunology
2455:10.1002/eji.200526192
2000:Immunological Reviews
1962:10.1007/s002510050250
1660:myeloid lineage cells
893:inflammatory response
539:tracheobronchial tree
519:stroma of bone marrow
6336:Interleukin receptor
5059:: CYTOKINE SYNTHESIS
4980:at Wikimedia Commons
4863:Kidney International
4714:Trends in Immunology
4455:(Pt 12): 1908–1911.
4221:10.1136/gut.50.2.191
3717:10.1038/icb.2010.100
833:B cell proliferation
803:leukocyte chemotaxis
788:response to activity
657:extracellular region
473:right adrenal cortex
357:1 E4|1 56.89 cM
318:Chromosome 1 (mouse)
216:Chromosome 1 (human)
69:List of PDB id codes
42:Available structures
6468:Denileukin diftitox
5906:Interferon type III
4461:2001AcCrD..57.1908J
4418:(21): 12906–12911.
4324:1993PNAS...9011267H
4318:(23): 11267–11271.
2585:2009PNAS..106.5761S
2339:2012PLoSO...733628L
1803:in the human body.
1514:and comprises five
818:response to insulin
662:extracellular space
477:left adrenal cortex
7040:E (interleukin 25)
4648:Blood Purification
1735:multiple sclerosis
1656:Toll-Like Receptor
1571:type 2 cannabinoid
1547:regulatory T cells
1468:interferons type-I
1168:ENSMUSG00000016529
943:liver regeneration
671:Biological process
650:Cellular component
614:Molecular function
7577:
7576:
7573:
7572:
7542:(signals through
7523:(signals through
7509:(signals through
7499:(signals through
7123:Binding proteins:
6453:Adargileukin alfa
6302:
6301:
6195:
6194:
6153:
6152:
6050:
6049:
6046:
6045:
5854:
5853:
5532:
5531:
5187:
5186:
4976:Media related to
4943:(12): 1093–1101.
4660:10.1159/000063553
4541:BMC Biotechnology
4127:(10): 1341–1346.
3538:(Pt 1): 287–291.
3399:(10): 1095–1104.
3393:Nature Immunology
3283:(14): 3570–3581.
2917:(12): 5936–5944.
2777:(12): 1666–1668.
2579:(14): 5761–5766.
2530:(10): 1977–1989.
2448:(10): 2991–3001.
1728:physical exercise
1685:allergic reaction
1567:beta-2 adrenergic
1526:, namely type-II
1388:), also known as
1379:
1378:
1375:
1374:
1348:
1347:
1313:
1312:
1292:
1291:
1266:
1265:
1245:
1244:
1219:
1218:
1200:
1199:
1174:
1173:
1155:
1154:
1129:
1128:
1110:
1109:
1058:
1057:
631:cytokine activity
598:
597:
594:
593:
563:
562:
550:
549:
523:entorhinal cortex
488:
487:
461:left uterine tube
386:
385:
285:
284:
112:
111:
108:
107:
52:Ortholog search:
7602:
7565:Efineptakin alfa
7560:Efavaleukin alfa
7462:
7461:
6429:Decoy receptors:
6329:
6322:
6315:
6306:
6305:
5933:
5932:
5865:
5864:
5648:
5647:
5633:
5632:
5245:
5244:
5236:
5235:
5214:
5207:
5200:
5191:
5190:
5173:
5158:
5143:
5128:
5113:
5098:
5083:
5068:
5053:
5038:
5018:
5011:
5004:
4995:
4994:
4975:
4960:
4931:
4921:
4888:
4878:
4869:(4): 1216–1233.
4853:
4824:
4795:
4766:
4737:
4708:
4691:(4–5): 403–412.
4679:
4642:
4613:
4576:
4566:
4556:
4522:
4521:
4511:
4487:
4481:
4480:
4444:
4438:
4437:
4427:
4403:
4397:
4396:
4386:
4362:
4356:
4355:
4345:
4335:
4303:
4297:
4290:
4284:
4283:
4281:
4280:
4256:
4243:
4242:
4232:
4200:
4191:
4190:
4180:
4171:(5): 2783–2789.
4156:
4147:
4146:
4136:
4112:
4106:
4105:
4077:
4071:
4070:
4049:
4043:
4042:
4019:Gastroenterology
4010:
4004:
4003:
3986:(6): 1461–1472.
3980:Gastroenterology
3974:
3968:
3967:
3950:(6): 1473–1482.
3944:Gastroenterology
3938:
3932:
3931:
3903:
3897:
3896:
3889:
3883:
3882:
3846:
3840:
3839:
3829:
3797:
3791:
3790:
3753:
3747:
3746:
3728:
3700:
3694:
3693:
3657:
3648:
3647:
3637:
3628:(4): 1106–1117.
3613:
3607:
3606:
3596:
3572:
3566:
3565:
3555:
3523:
3517:
3516:
3480:
3474:
3473:
3463:
3431:
3425:
3424:
3388:
3382:
3381:
3353:
3347:
3346:
3336:
3312:
3303:
3302:
3292:
3268:
3259:
3258:
3221:
3215:
3214:
3204:
3195:(7): 2143–2151.
3180:
3174:
3173:
3155:
3146:(3): 1723–1729.
3131:
3125:
3124:
3088:
3082:
3081:
3071:
3047:
3041:
3040:
3030:
2998:
2992:
2991:
2981:
2964:(9): 5249–5263.
2949:
2943:
2942:
2906:
2897:
2896:
2871:(1–2): 165–168.
2860:
2849:
2848:
2838:
2829:(6): 1683–1690.
2814:
2805:
2804:
2786:
2762:
2753:
2752:
2742:
2710:
2701:
2700:
2690:
2673:(5): 1209–1220.
2658:
2652:
2651:
2623:
2617:
2616:
2606:
2596:
2564:
2558:
2557:
2547:
2524:The EMBO Journal
2515:
2509:
2508:
2498:
2474:
2468:
2467:
2457:
2433:
2427:
2426:
2408:
2380:
2371:
2370:
2360:
2350:
2318:
2312:
2311:
2301:
2291:
2263:
2257:
2256:
2246:
2214:
2208:
2207:
2197:
2165:
2159:
2158:
2130:
2124:
2123:
2113:
2081:
2075:
2074:
2064:
2040:
2034:
2033:
2023:
1991:
1982:
1981:
1945:
1936:
1935:
1924:
1918:
1917:
1906:
1900:
1890:
1879:
1869:
1666:Effect on tumors
1658:(TLR) triggered
1608:AU-rich elements
1478:(IFN-gamma) and
1417:STAT3 signalling
1413:IL-10 receptor-2
1409:IL-10 receptor-1
1361:
1360:
1332:
1325:
1308:
1296:
1295:
1287:
1275:
1274:
1271:RefSeq (protein)
1261:
1249:
1248:
1240:
1228:
1227:
1204:
1203:
1185:
1184:
1159:
1158:
1140:
1139:
1114:
1113:
1095:
1094:
1064:
1063:
604:
603:
590:
581:
574:
573:
559:
543:stria vascularis
499:
497:Top expressed in
492:
491:
453:cartilage tissue
437:
435:Top expressed in
430:
429:
409:
408:
392:
391:
382:
369:
358:
343:
336:
330:
319:
307:
291:
290:
281:
268:
257:
242:
235:
229:
218:
204:
188:
187:
182:
180:IL10 - orthologs
133:
126:
103:
66:
65:
60:
39:
38:
33:
21:
20:
7612:
7611:
7605:
7604:
7603:
7601:
7600:
7599:
7580:
7579:
7578:
7569:
7480:
7453:
7404:
7383:
7362:
7322:
7301:
7245:
7242:(against IL-22)
7213:
7172:
7169:(against IL-20)
7130:
7084:
7003:
6977:
6921:
6880:
6854:
6828:
6797:
6777:
6756:
6675:
6614:
6558:
6512:
6436:
6341:
6333:
6303:
6298:
6264:
6243:
6201:
6191:
6149:
6122:
6042:
6024:
5922:
5850:
5819:
5782:
5720:
5692:
5643:
5641:
5639:
5622:
5528:
5507:
5491:
5394:
5227:
5218:
5188:
5183:
5180:
5174:
5165:
5159:
5150:
5144:
5135:
5129:
5120:
5114:
5105:
5099:
5090:
5084:
5075:
5069:
5060:
5054:
5045:
5039:
5025:
5022:
4968:
4963:
4530:
4528:Further reading
4525:
4488:
4484:
4445:
4441:
4404:
4400:
4363:
4359:
4304:
4300:
4291:
4287:
4278:
4276:
4257:
4246:
4201:
4194:
4157:
4150:
4113:
4109:
4078:
4074:
4050:
4046:
4011:
4007:
3975:
3971:
3939:
3935:
3904:
3900:
3891:
3890:
3886:
3847:
3843:
3798:
3794:
3754:
3750:
3701:
3697:
3658:
3651:
3614:
3610:
3573:
3569:
3524:
3520:
3481:
3477:
3432:
3428:
3389:
3385:
3364:(12): 948–955.
3354:
3350:
3313:
3306:
3277:Cancer Research
3269:
3262:
3222:
3218:
3181:
3177:
3132:
3128:
3089:
3085:
3048:
3044:
2999:
2995:
2950:
2946:
2907:
2900:
2861:
2852:
2815:
2808:
2763:
2756:
2711:
2704:
2659:
2655:
2624:
2620:
2565:
2561:
2516:
2512:
2475:
2471:
2434:
2430:
2397:10.1038/nri2711
2381:
2374:
2319:
2315:
2271:
2264:
2260:
2215:
2211:
2186:10.1038/nm.2106
2174:Nature Medicine
2166:
2162:
2131:
2127:
2082:
2078:
2041:
2037:
1992:
1985:
1946:
1939:
1926:
1925:
1921:
1908:
1907:
1903:
1891:
1882:
1870:
1861:
1857:
1838:
1813:
1811:PEGylated forms
1797:Crohn's disease
1790:
1677:
1675:Role in disease
1668:
1624:
1574:stimulation of
1533:
1504:
1433:
1421:phosphorylation
1370:View/Edit Mouse
1365:View/Edit Human
1328:
1321:
1318:Location (UCSC)
1304:
1283:
1257:
1236:
1149:ENSG00000136634
1042:
863:immune response
666:
645:
621:protein binding
586:
555:
546:
541:
537:
533:
529:
525:
521:
517:
513:
509:
495:
484:
479:
475:
471:
467:
463:
459:
455:
451:
447:
433:
377:
364:
356:
346:
345:
344:
337:
317:
294:Gene location (
276:
263:
255:
245:
244:
243:
236:
214:
191:Gene location (
142:
129:
122:
75:
53:
17:
12:
11:
5:
7610:
7609:
7598:
7597:
7592:
7575:
7574:
7571:
7570:
7568:
7567:
7562:
7553:
7552:
7550:Interleukin 35
7547:
7540:Interleukin 34
7537:
7535:Interleukin 32
7532:
7521:Interleukin 26
7518:
7507:Interleukin 24
7504:
7497:Interleukin 16
7494:
7488:
7486:
7482:
7481:
7479:
7478:
7470:
7468:
7459:
7455:
7454:
7452:
7451:
7442:
7441:
7439:Interleukin 38
7436:
7421:Interleukin 36
7414:
7412:
7406:
7405:
7403:
7402:
7400:Interleukin 33
7393:
7391:
7385:
7384:
7382:
7381:
7379:Interleukin 31
7372:
7370:
7364:
7363:
7361:
7360:
7355:
7344:Interleukin 28
7341:
7332:
7330:
7324:
7323:
7321:
7320:
7311:
7309:
7303:
7302:
7300:
7299:
7294:
7289:
7284:
7279:
7274:
7265:
7264:
7255:
7253:
7247:
7246:
7244:
7243:
7233:
7232:
7230:Interleukin 22
7223:
7221:
7215:
7214:
7212:
7211:
7206:
7197:
7196:
7194:Interleukin 21
7191:
7182:
7180:
7174:
7173:
7171:
7170:
7160:
7159:
7157:Interleukin 24
7154:
7152:Interleukin 20
7149:
7147:Interleukin 19
7140:
7138:
7132:
7131:
7129:
7128:
7119:
7118:
7113:
7111:Interleukin 37
7108:
7106:Interleukin 18
7103:
7094:
7092:
7086:
7085:
7083:
7082:
7077:
7072:
7067:
7062:
7057:
7048:
7047:
7020:Interleukin 17
7013:
7011:
7005:
7004:
7002:
7001:
6999:Interleukin 15
6996:
6987:
6985:
6979:
6978:
6976:
6975:
6970:
6965:
6956:
6955:
6953:Interleukin 13
6950:
6945:
6940:
6931:
6929:
6923:
6922:
6920:
6919:
6914:
6905:
6904:
6902:Interleukin 12
6899:
6890:
6888:
6882:
6881:
6879:
6878:
6873:
6864:
6862:
6856:
6855:
6853:
6852:
6847:
6838:
6836:
6830:
6829:
6827:
6826:
6817:
6816:
6807:
6805:
6799:
6798:
6796:
6795:
6787:
6785:
6779:
6778:
6776:
6775:
6766:
6764:
6758:
6757:
6755:
6754:
6749:
6744:
6739:
6734:
6729:
6724:
6719:
6714:
6709:
6700:
6699:
6694:
6685:
6683:
6677:
6676:
6674:
6673:
6664:
6663:
6658:
6653:
6644:
6643:
6634:
6633:
6624:
6622:
6616:
6615:
6613:
6612:
6607:
6598:
6597:
6588:
6587:
6585:Interleukin 13
6582:
6577:
6568:
6566:
6560:
6559:
6557:
6556:
6554:Promegapoietin
6551:
6546:
6541:
6536:
6531:
6522:
6520:
6514:
6513:
6511:
6510:
6505:
6500:
6491:
6490:
6485:
6480:
6478:Pegaldesleukin
6475:
6470:
6465:
6460:
6455:
6446:
6444:
6438:
6437:
6435:
6434:
6425:
6424:
6419:
6414:
6405:
6404:
6399:
6394:
6389:
6380:
6379:
6374:
6369:
6351:
6349:
6343:
6342:
6332:
6331:
6324:
6317:
6309:
6300:
6299:
6297:
6296:
6295:
6294:
6293:
6292:
6287:
6282:
6277:
6272:
6262:
6258:
6257:
6256:
6251:
6241:
6232:
6226:
6225:
6224:
6223:
6218:
6205:
6203:
6197:
6196:
6193:
6192:
6190:
6189:
6184:
6179:
6178:
6177:
6172:
6161:
6159:
6155:
6154:
6151:
6150:
6148:
6147:
6132:
6130:
6124:
6123:
6121:
6120:
6115:
6110:
6105:
6100:
6095:
6090:
6085:
6080:
6075:
6070:
6060:
6058:
6056:Ig superfamily
6052:
6051:
6048:
6047:
6044:
6043:
6041:
6040:
6034:
6032:
6026:
6025:
6023:
6022:
6017:
6012:
6007:
6002:
5997:
5992:
5987:
5982:
5977:
5972:
5967:
5962:
5957:
5952:
5947:
5941:
5939:
5930:
5924:
5923:
5921:
5920:
5919:
5918:
5913:
5903:
5898:
5893:
5888:
5883:
5873:
5871:
5862:
5856:
5855:
5852:
5851:
5849:
5848:
5843:
5838:
5833:
5827:
5825:
5821:
5820:
5818:
5817:
5812:
5807:
5802:
5796:
5794:
5784:
5783:
5781:
5780:
5779:
5778:
5773:
5768:
5763:
5752:
5747:
5742:
5737:
5731:
5729:
5722:
5721:
5719:
5718:
5713:
5708:
5702:
5700:
5694:
5693:
5691:
5690:
5685:
5680:
5675:
5666:
5656:
5654:
5645:
5630:
5624:
5623:
5621:
5620:
5615:
5610:
5605:
5600:
5595:
5590:
5585:
5580:
5575:
5570:
5565:
5564:
5563:
5558:
5548:
5542:
5540:
5534:
5533:
5530:
5529:
5527:
5526:
5521:
5515:
5513:
5509:
5508:
5506:
5505:
5499:
5497:
5493:
5492:
5490:
5489:
5484:
5479:
5474:
5469:
5464:
5459:
5454:
5449:
5444:
5439:
5434:
5429:
5424:
5419:
5414:
5409:
5402:
5400:
5396:
5395:
5393:
5392:
5387:
5382:
5377:
5372:
5367:
5362:
5357:
5352:
5347:
5342:
5336:
5331:
5326:
5321:
5316:
5311:
5306:
5301:
5296:
5291:
5286:
5281:
5275:
5269:
5263:
5257:
5251:
5249:
5242:
5233:
5229:
5228:
5221:Cell signaling
5217:
5216:
5209:
5202:
5194:
5185:
5184:
5182:
5181:
5175:
5168:
5166:
5160:
5153:
5151:
5145:
5138:
5136:
5130:
5123:
5121:
5115:
5108:
5106:
5100:
5093:
5091:
5085:
5078:
5076:
5070:
5063:
5061:
5055:
5048:
5046:
5040:
5033:
5030:
5027:
5026:
5021:
5020:
5013:
5006:
4998:
4992:
4991:
4984:Interleukin-10
4981:
4967:
4966:External links
4964:
4962:
4961:
4932:
4889:
4854:
4836:(2): 185–192.
4825:
4807:(4): 287–289.
4796:
4778:(4): 281–285.
4767:
4749:(4): 269–272.
4738:
4709:
4680:
4654:(5): 485–488.
4643:
4625:(1): 683–765.
4614:
4577:
4531:
4529:
4526:
4524:
4523:
4502:(1): 134–141.
4482:
4439:
4398:
4357:
4298:
4285:
4244:
4215:(2): 191–195.
4192:
4148:
4107:
4088:(2): 187–192.
4072:
4061:(4): 648–651.
4044:
4025:(2): 383–389.
4005:
3969:
3933:
3914:(6): 754–759.
3898:
3884:
3841:
3792:
3748:
3711:(3): 447–457.
3695:
3649:
3608:
3587:(5): 554–561.
3567:
3518:
3491:(6): 512–515.
3475:
3446:(2): 128–135.
3426:
3405:10.1038/ni1503
3383:
3348:
3327:(6): 781–796.
3304:
3260:
3233:(1): 231–238.
3216:
3175:
3126:
3099:(2): 208–214.
3083:
3062:(4): 624–629.
3042:
3013:(2): 579–584.
2993:
2944:
2898:
2850:
2806:
2754:
2725:(4): 915–924.
2702:
2653:
2634:(1): 683–765.
2618:
2559:
2510:
2489:(1): 292–296.
2469:
2428:
2391:(3): 170–181.
2372:
2313:
2282:(6): 414–428.
2269:
2258:
2209:
2180:(4): 452–459.
2160:
2141:(1): 929–979.
2125:
2076:
2055:(6): 591–601.
2035:
2006:(1): 205–218.
1983:
1956:(2): 120–128.
1950:Immunogenetics
1937:
1919:
1901:
1880:
1858:
1856:
1853:
1837:
1834:
1812:
1809:
1789:
1786:
1770:gastric cancer
1676:
1673:
1667:
1664:
1623:
1620:
1604:mRNA stability
1531:
1528:T helper cells
1503:
1500:
1432:
1429:
1396:), is an anti-
1382:Interleukin 10
1377:
1376:
1373:
1372:
1367:
1357:
1356:
1350:
1349:
1346:
1345:
1343:
1341:
1334:
1333:
1326:
1319:
1315:
1314:
1311:
1310:
1300:
1299:
1293:
1290:
1289:
1279:
1278:
1272:
1268:
1267:
1264:
1263:
1253:
1252:
1246:
1243:
1242:
1232:
1231:
1225:
1221:
1220:
1217:
1216:
1208:
1207:
1201:
1198:
1197:
1189:
1188:
1182:
1176:
1175:
1172:
1171:
1163:
1162:
1156:
1153:
1152:
1144:
1143:
1137:
1131:
1130:
1127:
1126:
1118:
1117:
1111:
1108:
1107:
1099:
1098:
1092:
1086:
1085:
1080:
1075:
1071:
1070:
1060:
1059:
1056:
1055:
1044:
1043:
1041:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
674:
672:
668:
667:
665:
664:
659:
653:
651:
647:
646:
644:
643:
638:
633:
628:
623:
617:
615:
611:
610:
600:
599:
596:
595:
592:
591:
583:
582:
571:
565:
564:
561:
560:
552:
551:
548:
547:
545:
544:
540:
536:
532:
528:
524:
520:
516:
512:
508:
504:
501:
500:
489:
486:
485:
483:
482:
478:
474:
470:
469:gastric mucosa
466:
462:
458:
454:
450:
446:
442:
439:
438:
426:
425:
417:
406:
400:
399:
396:RNA expression
388:
387:
384:
383:
375:
371:
370:
362:
359:
354:
348:
347:
338:
331:
325:
321:
320:
315:
309:
308:
300:
299:
287:
286:
283:
282:
274:
270:
269:
261:
258:
253:
247:
246:
237:
230:
224:
220:
219:
212:
206:
205:
197:
196:
184:
183:
140:
136:
135:
127:
119:
118:
114:
113:
110:
109:
106:
105:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
9:
6:
4:
3:
2:
7608:
7607:
7596:
7593:
7591:
7588:
7587:
7585:
7566:
7563:
7561:
7558:
7555:
7554:
7551:
7548:
7545:
7541:
7538:
7536:
7533:
7530:
7526:
7522:
7519:
7516:
7512:
7508:
7505:
7502:
7498:
7495:
7493:
7490:
7489:
7487:
7483:
7476:
7472:
7471:
7469:
7467:
7463:
7460:
7456:
7450:
7447:
7444:
7443:
7440:
7437:
7434:
7430:
7426:
7422:
7419:
7416:
7415:
7413:
7411:
7407:
7401:
7398:
7395:
7394:
7392:
7390:
7386:
7380:
7377:
7374:
7373:
7371:
7369:
7365:
7359:
7356:
7353:
7349:
7345:
7342:
7340:
7337:
7334:
7333:
7331:
7329:
7325:
7319:
7316:
7313:
7312:
7310:
7308:
7304:
7298:
7295:
7293:
7292:Tildrakizumab
7290:
7288:
7285:
7283:
7280:
7278:
7275:
7273:
7270:
7267:
7266:
7263:
7260:
7257:
7256:
7254:
7252:
7248:
7241:
7238:
7235:
7234:
7231:
7228:
7225:
7224:
7222:
7220:
7216:
7210:
7207:
7205:
7202:
7199:
7198:
7195:
7192:
7190:
7187:
7184:
7183:
7181:
7179:
7175:
7168:
7165:
7162:
7161:
7158:
7155:
7153:
7150:
7148:
7145:
7142:
7141:
7139:
7137:
7133:
7127:
7124:
7121:
7120:
7117:
7114:
7112:
7109:
7107:
7104:
7102:
7099:
7096:
7095:
7093:
7091:
7087:
7081:
7078:
7076:
7073:
7071:
7068:
7066:
7063:
7061:
7058:
7056:
7053:
7050:
7049:
7045:
7041:
7037:
7033:
7029:
7025:
7021:
7018:
7015:
7014:
7012:
7010:
7006:
7000:
6997:
6995:
6992:
6989:
6988:
6986:
6984:
6980:
6974:
6971:
6969:
6966:
6964:
6961:
6958:
6957:
6954:
6951:
6949:
6948:Interleukin 4
6946:
6944:
6941:
6939:
6936:
6933:
6932:
6930:
6928:
6924:
6918:
6915:
6913:
6910:
6907:
6906:
6903:
6900:
6898:
6897:Edodekin alfa
6895:
6892:
6891:
6889:
6887:
6883:
6877:
6874:
6872:
6869:
6866:
6865:
6863:
6861:
6857:
6851:
6848:
6846:
6843:
6840:
6839:
6837:
6835:
6831:
6825:
6822:
6819:
6818:
6815:
6814:Interleukin 9
6812:
6809:
6808:
6806:
6804:
6800:
6793:
6789:
6788:
6786:
6784:
6780:
6774:
6773:Interleukin 7
6771:
6768:
6767:
6765:
6763:
6759:
6753:
6750:
6748:
6745:
6743:
6740:
6738:
6735:
6733:
6730:
6728:
6725:
6723:
6720:
6718:
6715:
6713:
6710:
6708:
6705:
6702:
6701:
6698:
6697:Interleukin 6
6695:
6693:
6692:Atexakin alfa
6690:
6687:
6686:
6684:
6682:
6678:
6672:
6669:
6666:
6665:
6662:
6659:
6657:
6654:
6652:
6649:
6646:
6645:
6642:
6639:
6636:
6635:
6632:
6631:Interleukin 5
6629:
6626:
6625:
6623:
6621:
6617:
6611:
6608:
6606:
6603:
6600:
6599:
6596:
6593:
6590:
6589:
6586:
6583:
6581:
6580:Interleukin 4
6578:
6576:
6573:
6570:
6569:
6567:
6565:
6561:
6555:
6552:
6550:
6547:
6545:
6542:
6540:
6537:
6535:
6534:Interleukin 3
6532:
6530:
6527:
6524:
6523:
6521:
6519:
6515:
6509:
6506:
6504:
6501:
6499:
6496:
6493:
6492:
6489:
6486:
6484:
6481:
6479:
6476:
6474:
6473:Interleukin 2
6471:
6469:
6466:
6464:
6461:
6459:
6456:
6454:
6451:
6448:
6447:
6445:
6443:
6439:
6433:
6430:
6427:
6426:
6423:
6420:
6418:
6415:
6413:
6410:
6407:
6406:
6403:
6400:
6398:
6395:
6393:
6390:
6388:
6385:
6382:
6381:
6378:
6375:
6373:
6370:
6367:
6363:
6359:
6358:Interleukin 1
6356:
6353:
6352:
6350:
6348:
6344:
6340:
6337:
6330:
6325:
6323:
6318:
6316:
6311:
6310:
6307:
6291:
6288:
6286:
6283:
6281:
6278:
6276:
6273:
6271:
6268:
6267:
6266:
6259:
6255:
6252:
6250:
6247:
6246:
6245:
6238:
6237:
6236:
6233:
6231:
6228:
6227:
6222:
6219:
6217:
6214:
6213:
6212:
6211:
6207:
6206:
6204:
6198:
6188:
6185:
6183:
6180:
6176:
6173:
6171:
6168:
6167:
6166:
6165:Hematopoietic
6163:
6162:
6160:
6156:
6145:
6141:
6137:
6134:
6133:
6131:
6129:
6125:
6119:
6116:
6114:
6111:
6109:
6106:
6104:
6101:
6099:
6096:
6094:
6091:
6089:
6086:
6084:
6081:
6079:
6076:
6074:
6071:
6069:
6065:
6062:
6061:
6059:
6057:
6053:
6039:
6036:
6035:
6033:
6031:
6027:
6021:
6018:
6016:
6013:
6011:
6008:
6006:
6003:
6001:
5998:
5996:
5993:
5991:
5988:
5986:
5983:
5981:
5978:
5976:
5973:
5971:
5968:
5966:
5963:
5961:
5958:
5956:
5953:
5951:
5948:
5946:
5943:
5942:
5940:
5938:
5934:
5931:
5929:
5925:
5917:
5914:
5912:
5909:
5908:
5907:
5904:
5902:
5899:
5897:
5894:
5892:
5889:
5887:
5884:
5882:
5878:
5875:
5874:
5872:
5870:
5866:
5863:
5861:
5857:
5847:
5844:
5842:
5839:
5837:
5834:
5832:
5829:
5828:
5826:
5822:
5816:
5813:
5811:
5808:
5806:
5803:
5801:
5798:
5797:
5795:
5793:
5789:
5785:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5758:
5757:
5756:
5753:
5751:
5748:
5746:
5743:
5741:
5738:
5736:
5733:
5732:
5730:
5728:
5723:
5717:
5714:
5712:
5709:
5707:
5704:
5703:
5701:
5699:
5695:
5689:
5686:
5684:
5681:
5679:
5676:
5674:
5670:
5667:
5665:
5661:
5658:
5657:
5655:
5653:
5649:
5646:
5638:
5634:
5631:
5629:
5625:
5619:
5616:
5614:
5611:
5609:
5606:
5604:
5601:
5599:
5596:
5594:
5591:
5589:
5586:
5584:
5581:
5579:
5576:
5574:
5573:TNFSF5/CD40LG
5571:
5569:
5566:
5562:
5559:
5557:
5554:
5553:
5552:
5549:
5547:
5544:
5543:
5541:
5539:
5535:
5525:
5522:
5520:
5517:
5516:
5514:
5510:
5504:
5501:
5500:
5498:
5494:
5488:
5485:
5483:
5480:
5478:
5475:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5453:
5450:
5448:
5445:
5443:
5440:
5438:
5435:
5433:
5430:
5428:
5425:
5423:
5420:
5418:
5415:
5413:
5410:
5407:
5404:
5403:
5401:
5397:
5391:
5388:
5386:
5383:
5381:
5378:
5376:
5373:
5371:
5368:
5366:
5363:
5361:
5358:
5356:
5353:
5351:
5348:
5346:
5343:
5340:
5337:
5335:
5332:
5330:
5327:
5325:
5322:
5320:
5317:
5315:
5312:
5310:
5307:
5305:
5302:
5300:
5297:
5295:
5292:
5290:
5287:
5285:
5282:
5279:
5276:
5273:
5270:
5267:
5264:
5261:
5258:
5256:
5253:
5252:
5250:
5246:
5243:
5241:
5237:
5234:
5230:
5226:
5222:
5215:
5210:
5208:
5203:
5201:
5196:
5195:
5192:
5178:
5172:
5167:
5163:
5157:
5152:
5148:
5142:
5137:
5133:
5127:
5122:
5118:
5112:
5107:
5103:
5097:
5092:
5088:
5082:
5077:
5073:
5067:
5062:
5058:
5052:
5047:
5043:
5037:
5032:
5031:
5028:
5019:
5014:
5012:
5007:
5005:
5000:
4999:
4996:
4989:
4985:
4982:
4979:
4974:
4970:
4969:
4958:
4954:
4950:
4946:
4942:
4938:
4933:
4929:
4925:
4920:
4915:
4911:
4907:
4903:
4899:
4895:
4890:
4886:
4882:
4877:
4872:
4868:
4864:
4860:
4855:
4851:
4847:
4843:
4839:
4835:
4831:
4826:
4822:
4818:
4814:
4810:
4806:
4802:
4797:
4793:
4789:
4785:
4781:
4777:
4773:
4768:
4764:
4760:
4756:
4752:
4748:
4744:
4739:
4735:
4731:
4727:
4723:
4719:
4715:
4710:
4706:
4702:
4698:
4694:
4690:
4686:
4681:
4677:
4673:
4669:
4665:
4661:
4657:
4653:
4649:
4644:
4640:
4636:
4632:
4628:
4624:
4620:
4615:
4611:
4607:
4603:
4599:
4595:
4591:
4587:
4583:
4578:
4574:
4570:
4565:
4560:
4555:
4550:
4546:
4542:
4538:
4533:
4532:
4519:
4515:
4510:
4505:
4501:
4497:
4493:
4486:
4478:
4474:
4470:
4466:
4462:
4458:
4454:
4450:
4443:
4435:
4431:
4426:
4421:
4417:
4413:
4409:
4402:
4394:
4390:
4385:
4380:
4376:
4372:
4368:
4361:
4353:
4349:
4344:
4339:
4334:
4329:
4325:
4321:
4317:
4313:
4309:
4302:
4296:
4295:
4289:
4275:on 2015-12-22
4274:
4270:
4266:
4262:
4255:
4253:
4251:
4249:
4240:
4236:
4231:
4226:
4222:
4218:
4214:
4210:
4206:
4199:
4197:
4188:
4184:
4179:
4174:
4170:
4166:
4162:
4155:
4153:
4144:
4140:
4135:
4130:
4126:
4122:
4118:
4111:
4103:
4099:
4095:
4091:
4087:
4083:
4076:
4068:
4064:
4060:
4056:
4048:
4040:
4036:
4032:
4028:
4024:
4020:
4016:
4009:
4001:
3997:
3993:
3989:
3985:
3981:
3973:
3965:
3961:
3957:
3953:
3949:
3945:
3937:
3929:
3925:
3921:
3917:
3913:
3909:
3902:
3894:
3888:
3880:
3876:
3872:
3868:
3864:
3860:
3856:
3852:
3845:
3837:
3833:
3828:
3823:
3819:
3815:
3811:
3807:
3803:
3796:
3788:
3784:
3780:
3776:
3772:
3768:
3764:
3760:
3752:
3744:
3740:
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3727:
3722:
3718:
3714:
3710:
3706:
3699:
3691:
3687:
3683:
3679:
3675:
3671:
3667:
3663:
3656:
3654:
3645:
3641:
3636:
3631:
3627:
3623:
3619:
3612:
3604:
3600:
3595:
3590:
3586:
3582:
3578:
3571:
3563:
3559:
3554:
3549:
3545:
3541:
3537:
3533:
3529:
3522:
3514:
3510:
3506:
3502:
3498:
3494:
3490:
3486:
3479:
3471:
3467:
3462:
3457:
3453:
3449:
3445:
3441:
3437:
3430:
3422:
3418:
3414:
3410:
3406:
3402:
3398:
3394:
3387:
3379:
3375:
3371:
3367:
3363:
3359:
3352:
3344:
3340:
3335:
3330:
3326:
3322:
3318:
3311:
3309:
3300:
3296:
3291:
3286:
3282:
3278:
3274:
3267:
3265:
3256:
3252:
3248:
3244:
3240:
3236:
3232:
3228:
3220:
3212:
3208:
3203:
3198:
3194:
3190:
3186:
3179:
3171:
3167:
3163:
3159:
3154:
3149:
3145:
3141:
3137:
3130:
3122:
3118:
3114:
3110:
3106:
3102:
3098:
3094:
3087:
3079:
3075:
3070:
3065:
3061:
3057:
3053:
3046:
3038:
3034:
3029:
3024:
3020:
3016:
3012:
3008:
3004:
2997:
2989:
2985:
2980:
2975:
2971:
2967:
2963:
2959:
2955:
2948:
2940:
2936:
2932:
2928:
2924:
2920:
2916:
2912:
2905:
2903:
2894:
2890:
2886:
2882:
2878:
2874:
2870:
2866:
2859:
2857:
2855:
2846:
2842:
2837:
2832:
2828:
2824:
2820:
2813:
2811:
2802:
2798:
2794:
2790:
2785:
2780:
2776:
2772:
2771:FASEB Journal
2768:
2761:
2759:
2750:
2746:
2741:
2736:
2732:
2728:
2724:
2720:
2716:
2709:
2707:
2698:
2694:
2689:
2684:
2680:
2676:
2672:
2668:
2664:
2657:
2649:
2645:
2641:
2637:
2633:
2629:
2622:
2614:
2610:
2605:
2600:
2595:
2590:
2586:
2582:
2578:
2574:
2570:
2563:
2555:
2551:
2546:
2541:
2537:
2533:
2529:
2525:
2521:
2514:
2506:
2502:
2497:
2492:
2488:
2484:
2480:
2473:
2465:
2461:
2456:
2451:
2447:
2443:
2439:
2432:
2424:
2420:
2416:
2412:
2407:
2402:
2398:
2394:
2390:
2386:
2379:
2377:
2368:
2364:
2359:
2354:
2349:
2344:
2340:
2336:
2333:(3): e33628.
2332:
2328:
2324:
2317:
2309:
2305:
2300:
2295:
2290:
2285:
2281:
2277:
2273:
2262:
2254:
2250:
2245:
2240:
2236:
2232:
2228:
2224:
2220:
2213:
2205:
2201:
2196:
2191:
2187:
2183:
2179:
2175:
2171:
2164:
2156:
2152:
2148:
2144:
2140:
2136:
2129:
2121:
2117:
2112:
2107:
2103:
2099:
2095:
2091:
2087:
2080:
2072:
2068:
2063:
2058:
2054:
2050:
2046:
2039:
2031:
2027:
2022:
2017:
2013:
2009:
2005:
2001:
1997:
1990:
1988:
1979:
1975:
1971:
1967:
1963:
1959:
1955:
1951:
1944:
1942:
1933:
1929:
1923:
1915:
1911:
1905:
1898:
1894:
1889:
1887:
1885:
1877:
1873:
1868:
1866:
1864:
1859:
1852:
1849:
1847:
1843:
1833:
1831:
1830:pegilodecakin
1827:
1823:
1818:
1808:
1804:
1802:
1798:
1794:
1785:
1781:
1779:
1775:
1771:
1767:
1763:
1759:
1754:
1752:
1748:
1743:
1740:
1736:
1731:
1729:
1725:
1720:
1716:
1713:
1709:
1705:
1701:
1697:
1693:
1688:
1686:
1682:
1672:
1663:
1661:
1657:
1651:
1649:
1645:
1641:
1637:
1633:
1629:
1619:
1617:
1613:
1609:
1605:
1601:
1597:
1593:
1589:
1585:
1581:
1577:
1572:
1568:
1564:
1560:
1556:
1552:
1548:
1544:
1541:
1537:
1529:
1525:
1521:
1517:
1513:
1509:
1499:
1497:
1493:
1489:
1485:
1481:
1477:
1473:
1469:
1465:
1461:
1457:
1453:
1449:
1444:
1442:
1438:
1428:
1426:
1422:
1418:
1414:
1410:
1406:
1402:
1399:
1395:
1391:
1387:
1383:
1371:
1366:
1362:
1358:
1355:
1351:
1344:
1342:
1339:
1335:
1331:
1327:
1324:
1320:
1316:
1309:
1307:
1301:
1297:
1294:
1288:
1286:
1280:
1276:
1273:
1269:
1262:
1260:
1254:
1250:
1247:
1241:
1239:
1233:
1229:
1226:
1224:RefSeq (mRNA)
1222:
1215:
1214:
1209:
1205:
1202:
1196:
1195:
1190:
1186:
1183:
1181:
1177:
1170:
1169:
1164:
1160:
1157:
1151:
1150:
1145:
1141:
1138:
1136:
1132:
1125:
1124:
1119:
1115:
1112:
1106:
1105:
1100:
1096:
1093:
1091:
1087:
1084:
1081:
1079:
1076:
1072:
1069:
1065:
1061:
1054:
1050:
1045:
1039:
1036:
1034:
1031:
1029:
1026:
1024:
1021:
1019:
1016:
1014:
1011:
1009:
1006:
1004:
1001:
999:
996:
994:
991:
989:
986:
984:
981:
979:
976:
974:
971:
969:
966:
964:
961:
959:
956:
954:
951:
949:
946:
944:
941:
939:
936:
934:
931:
929:
926:
924:
921:
919:
916:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
675:
673:
670:
669:
663:
660:
658:
655:
654:
652:
649:
648:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
618:
616:
613:
612:
609:
608:Gene ontology
605:
601:
589:
584:
580:
575:
572:
570:
566:
558:
553:
542:
538:
534:
530:
526:
522:
518:
514:
510:
506:
505:
502:
498:
493:
490:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
443:
440:
436:
431:
428:
427:
424:
422:
418:
416:
415:
411:
410:
407:
405:
401:
397:
393:
389:
381:
376:
372:
368:
363:
353:
349:
342:
335:
329:
322:
314:
310:
306:
301:
297:
292:
288:
280:
275:
271:
267:
262:
252:
248:
241:
234:
228:
221:
217:
211:
207:
203:
198:
194:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
137:
132:
125:
120:
115:
104:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
7595:Interleukins
7556:
7544:M-CSFR/CSF1R
7531:heterodimer)
7517:heterodimer)
7446:Antagonists:
7445:
7417:
7396:
7375:
7335:
7314:
7287:Risankizumab
7268:
7258:
7236:
7226:
7209:NNC0114-0006
7204:NNC0114-0005
7200:
7185:
7163:
7143:
7122:
7097:
7051:
7016:
6990:
6973:Tralokinumab
6968:Lebrikizumab
6963:Anrukinzumab
6959:
6934:
6908:
6893:
6867:
6849:
6841:
6820:
6810:
6769:
6712:Clazakizumab
6703:
6688:
6667:
6651:Benralizumab
6647:
6638:Antagonists:
6637:
6627:
6610:Pascolizumab
6601:
6592:Antagonists:
6591:
6571:
6525:
6494:
6449:
6428:
6408:
6384:Antagonists:
6383:
6354:
6284:
6260:
6239:
6208:
6200:By function/
5911:IL28/IFNL2+3
5876:
5176:
5161:
5146:
5131:
5116:
5101:
5086:
5071:
5056:
5041:
4940:
4936:
4901:
4897:
4866:
4862:
4833:
4829:
4804:
4800:
4775:
4771:
4746:
4742:
4720:(1): 36–43.
4717:
4713:
4688:
4684:
4651:
4647:
4622:
4618:
4585:
4581:
4544:
4540:
4499:
4495:
4485:
4452:
4448:
4442:
4415:
4411:
4401:
4377:(1): 35–46.
4374:
4370:
4360:
4315:
4311:
4301:
4293:
4288:
4277:. Retrieved
4273:the original
4268:
4264:
4212:
4208:
4168:
4164:
4124:
4120:
4110:
4085:
4081:
4075:
4058:
4054:
4047:
4022:
4018:
4008:
3983:
3979:
3972:
3947:
3943:
3936:
3911:
3907:
3901:
3887:
3854:
3850:
3844:
3809:
3805:
3795:
3762:
3758:
3751:
3726:10533/132162
3708:
3704:
3698:
3668:(1): 26–34.
3665:
3661:
3625:
3621:
3611:
3584:
3580:
3570:
3535:
3531:
3521:
3488:
3484:
3478:
3443:
3439:
3429:
3396:
3392:
3386:
3361:
3357:
3351:
3324:
3320:
3280:
3276:
3230:
3226:
3219:
3192:
3188:
3178:
3143:
3139:
3129:
3096:
3092:
3086:
3059:
3055:
3045:
3010:
3006:
2996:
2961:
2957:
2947:
2914:
2910:
2868:
2864:
2826:
2822:
2774:
2770:
2722:
2718:
2670:
2666:
2656:
2631:
2627:
2621:
2576:
2572:
2562:
2527:
2523:
2513:
2486:
2482:
2472:
2445:
2441:
2431:
2388:
2384:
2330:
2326:
2316:
2279:
2275:
2261:
2226:
2222:
2212:
2177:
2173:
2163:
2138:
2134:
2128:
2096:(1): 15–28.
2093:
2089:
2079:
2052:
2048:
2038:
2003:
1999:
1953:
1949:
1931:
1922:
1913:
1904:
1850:
1839:
1836:Interactions
1825:
1821:
1814:
1805:
1791:
1782:
1755:
1744:
1732:
1721:
1717:
1689:
1678:
1669:
1652:
1636:MHC class II
1625:
1618:or miR-106.
1512:chromosome 1
1507:
1505:
1445:
1434:
1404:
1398:inflammatory
1393:
1389:
1385:
1381:
1380:
1303:
1282:
1256:
1235:
1211:
1192:
1166:
1147:
1121:
1102:
1082:
1077:
748:human ageing
419:
412:
378:130,952,711
365:130,947,582
277:206,774,541
264:206,767,602
139:External IDs
74:
18:
7297:Ustekinumab
7277:Briakinumab
7269:Antibodies:
7240:Fezakinumab
7237:Antibodies:
7201:Antibodies:
7189:Denenicokin
7164:Antibodies:
7101:Iboctadekin
7080:Vunakizumab
7075:Secukinumab
7065:Perakizumab
7052:Antibodies:
6960:Antibodies:
6917:Ustekinumab
6912:Briakinumab
6909:Antibodies:
6821:Antibodies:
6747:Tocilizumab
6717:Elsilimomab
6704:Antibodies:
6656:Mepolizumab
6648:Antibodies:
6602:Antibodies:
6529:Daniplestim
6498:Basiliximab
6495:Antibodies:
6463:Celmoleukin
6458:Aldesleukin
6422:Lutikizumab
6417:Gevokizumab
6412:Canakinumab
6409:Antibodies:
6128:IL17 family
5869:IL10 family
5788:IL12 family
5640:(grouped by
5628:Interleukin
5551:Lymphotoxin
5024:PDB gallery
3812:: 437–457.
3321:Cancer Cell
2229:: 176–185.
1712:macrophages
1640:macrophages
1634:cytokines,
1628:pleiotropic
1580:Fc receptor
1524:lymphocytes
693:hemopoiesis
481:granulocyte
449:gallbladder
117:Identifiers
7584:Categories
7352:B (IFN-λ3)
7348:A (IFN-λ2)
7282:Guselkumab
7272:Brazikumab
7167:Fletikumab
7070:Remtolumab
7060:Ixekizumab
7055:Brodalumab
6938:Binetrakin
6876:Oprelvekin
6845:Ilodecakin
6824:Enokizumab
6737:Siltuximab
6727:Olokizumab
6661:Reslizumab
6595:Pitrakinra
6575:Binetrakin
6544:Milodistim
6539:Leridistim
6508:Inolimomab
6483:Teceleukin
6402:Isunakinra
6339:modulators
6235:Lymphokine
6073:IL1B/IL1F2
6068:IL1A/IL1F1
6064:IL1 family
5928:Interferon
5916:IL29/IFNL1
4588:: 101610.
4279:2015-12-10
3857:: 114125.
3765:: 155351.
2406:1822/29592
1899:, May 2017
1878:, May 2017
1855:References
1681:mast cells
1565:, such as
1536:mast cells
1441:amino-acid
465:lymph node
423:(ortholog)
160:HomoloGene
7557:Unsorted:
7418:Agonists:
7397:Agonists:
7376:Agonists:
7336:Agonists:
7315:Agonists:
7259:Agonists:
7227:Agonists:
7186:Agonists:
7144:Agonists:
7116:Tadekinig
7098:Agonists:
7017:Agonists:
6991:Agonists:
6935:Agonists:
6894:Agonists:
6868:Agonists:
6842:Agonists:
6811:Agonists:
6770:Agonists:
6752:Levilimab
6742:Sirukumab
6732:Sarilumab
6689:Agonists:
6628:Agonists:
6605:Dupilumab
6572:Agonists:
6549:Muplestim
6526:Agonists:
6450:Agonists:
6377:Pifonakin
6372:Mobenakin
6355:Agonists:
6113:33/IL1F11
6078:1Ra/IL1F3
5725:IL6 like/
5442:CXCL8/IL8
5240:Chemokine
5232:By family
5225:cytokines
4904:: 54–69.
4547:(1): 22.
3879:249070122
3787:226218796
3743:205150174
2049:Structure
1817:PEGylated
1764:) cells.
1753:ligands.
1612:microRNAs
1600:autocrine
1520:monocytes
1472:IFN-alpha
1462:(Mda-7),
1437:homodimer
1306:NP_034678
1285:NP_000563
1259:NM_010548
1238:NM_000572
1068:Orthologs
168:GeneCards
7511:IL-22Rα1
7477:instead.
6794:instead.
6722:mAb 1339
6707:ARGX-109
6671:TPI ASM8
6641:YM-90709
6392:Anakinra
6387:AF-12198
6230:Monokine
5759:+non IL
5644:subunit)
5642:receptor
5613:TNFSF13B
5561:TNFC/LTB
5556:TNFB/LTA
4957:16375755
4928:28365213
4885:15780075
4850:15180472
4821:12791314
4792:12791313
4763:12791310
4734:12495723
4705:12220553
4676:46867122
4668:12207099
4639:11244051
4610:85495400
4602:30923023
4573:19298643
4518:10231374
4477:11717514
4393:11485736
4371:Immunity
4239:11788558
4187:10946310
4143:12374540
4102:10052405
4067:12672180
4000:11113067
3964:11113068
3928:16716759
3871:35644427
3836:33588074
3779:33127257
3759:Cytokine
3735:20714339
3690:21058811
3682:22189514
3644:18383040
3603:10320650
3513:44759539
3505:11192058
3470:23159957
3421:10972672
3413:17767162
3378:26309093
3343:22172723
3299:22581824
3255:25596108
3211:11568001
3170:36990295
3121:39224241
3113:10746547
2988:11500393
2939:15960096
2845:10898505
2801:40794643
2793:10973911
2648:11244051
2613:19307576
2554:21468030
2505:10861064
2464:16184516
2415:20154735
2367:22438968
2327:PLOS ONE
2308:32259074
2253:30195028
2204:20208540
2155:15032600
2120:26200010
2090:Immunity
2030:19161426
1978:30126106
1895:–
1874:–
1842:interact
1822:in vitro
1793:Knockout
1747:melanoma
1724:myokines
1622:Function
1614:such as
1480:type-III
1419:via the
1411:and two
1401:cytokine
1354:Wikidata
1047:Sources:
527:epiblast
445:appendix
7529:IL-10Rβ
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