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Institute of Molecular Biotechnology

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evaluate and implement a wide range of novel technologies and instrumentations. These professional staff scientists also train users, help with experimental design, and disseminate expert knowledge. The IMBA scientists are not billed for core services, except for certain experiment-related consumables.
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In order to maintain the highest standard of research, the IMBA has installed a process of review and feedback led by an external Scientific Advisory Board (SAB) of internationally recognised scientists. The Board meets yearly and, together with group leaders, discusses the quality, significance, and
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Schmidt, Clara; Deyett, Alison; Ilmer, Tobias; Haendeler, Simon; Torres Caballero, Aranxa; Novatchkova, Maria; Netzer, Michael A.; Ceci Ginistrelli, Lavinia; Mancheno Juncosa, Estela; Bhattacharya, Tanishta; Mujadzic, Amra; Pimpale, Lokesh; Jahnel, Stefan M.; Martina, Cirigliano; Reumann, Daniel;
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Core scientific facilities within the IMBA provide services to facilitate research making use of stem cells, flies/worms, informatics, optics, molecular biology, comparative medicine, transgenics, protein chemistry, or graphic designs. These core facilities are managed by technical leaders who
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Hofbauer, Pablo; Jahnel, Stefan M.; Papai, Nora; Giesshammer, Magdalena; Deyett, Alison; Schmidt, Clara; Penc, Mirjam; Tavernini, Katherina; Grdseloff, Nastasja; Meledeth, Christy; Ginistrelli, Lavinia Ceci; Ctortecka, Claudia; Šalic, Šejla; Novatchkova, Maria; Mendjan, Sasha (June 2021).
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Eichmüller, Oliver L.; Corsini, Nina S.; Vértesy, Ábel; Morassut, Ilaria; Scholl, Theresa; Gruber, Victoria-Elisabeth; Peer, Angela M.; Chu, Julia; Novatchkova, Maria; Hainfellner, Johannes A.; Paredes, Mercedes F.; Feucht, Martha; Knoblich, Jürgen A. (2022-01-28).
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Schneider, Maximilian W. G.; Gibson, Bryan A.; Otsuka, Shotaro; Spicer, Maximilian F. D.; Petrovic, Mina; Blaukopf, Claudia; Langer, Christoph C. H.; Batty, Paul; Nagaraju, Thejaswi; Doolittle, Lynda K.; Rosen, Michael K.; Gerlich, Daniel W. (2022-09-01).
523:). Acceptance into the program is competitive and based on a formal selection procedure. There are two selections each year, deadlines are usually on April 30 and November 15. Participation in the program is a condition for doing a PhD at the IMBA. 1390:
Wimmer, Reiner A.; Leopoldi, Alexandra; Aichinger, Martin; Wick, Nikolaus; Hantusch, Brigitte; Novatchkova, Maria; Taubenschmid, Jasmin; Hämmerle, Monika; Esk, Christopher; Bagley, Joshua A.; Lindenhofer, Dominik (January 2019).
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Kagawa, Harunobu; Javali, Alok; Khoei, Heidar Heidari; Sommer, Theresa Maria; Sestini, Giovanni; Novatchkova, Maria; Scholte op Reimer, Yvonne; Castel, Gaël; Bruneau, Alexandre; Maenhoudt, Nina; Lammers, Jenna (2021-12-02).
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Rivron, Nicolas C.; Frias-Aldeguer, Javier; Vrij, Erik J.; Boisset, Jean-Charles; Korving, Jeroen; Vivié, Judith; Truckenmüller, Roman K.; van Oudenaarden, Alexander; van Blitterswijk, Clemens A.; Geijsen, Niels (May 2018).
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Esk, Christopher; Lindenhofer, Dominik; Haendeler, Simon; Wester, Roelof A.; Pflug, Florian; Schroeder, Benoit; Bagley, Joshua A.; Elling, Ulrich; Zuber, Johannes; Haeseler, Arndt von; Knoblich, Jürgen A. (2020-11-20).
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Mitter, Michael; Gasser, Catherina; Takacs, Zsuzsanna; Langer, Christoph C. H.; Tang, Wen; Jessberger, Gregor; Beales, Charlie T.; Neuner, Eva; Ameres, Stefan L.; Peters, Jan-Michael; Goloborodko, Anton (2020-10-01).
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Czech, Benjamin; Malone, Colin D.; Zhou, Rui; Stark, Alexander; Schlingeheyde, Catherine; Dus, Monica; Perrimon, Norbert; Kellis, Manolis; Wohlschlegel, James A.; Sachidanandam, Ravi; Hannon, Gregory J. (June 2008).
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Lancaster, Madeline A.; Renner, Magdalena; Martin, Carol-Anne; Wenzel, Daniel; Bicknell, Louise S.; Hurles, Matthew E.; Homfray, Tessa; Penninger, Josef M.; Jackson, Andrew P.; Knoblich, Juergen A. (2013-09-19).
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Lancaster, Madeline A.; Renner, Magdalena; Martin, Carol-Anne; Wenzel, Daniel; Bicknell, Louise S.; Hurles, Matthew E.; Homfray, Tessa; Penninger, Josef M.; Jackson, Andrew P.; Knoblich, Juergen A. (2013-09-19).
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Hofbauer, Pablo; Jahnel, Stefan; Papai, Nora; Giesshammer, Magdalena; Penc, Mirjam; Tavernini, Katherina; Grdseloff, Nastasja; Meledeth, Christy; Deyett, Alison; Schmidt, Clara; Ctortecka, Claudia (2020-07-06).
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Elling, Ulrich; Wimmer, Reiner A.; Leibbrandt, Andreas; Burkard, Thomas; Michlits, Georg; Leopoldi, Alexandra; Micheler, Thomas; Abdeen, Dana; Zhuk, Sergei; Aspalter, Irene M.; Handl, Cornelia (October 2017).
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Herzog, Veronika A.; Reichholf, Brian; Neumann, Tobias; Rescheneder, Philipp; Bhat, Pooja; Burkard, Thomas R.; Wlotzka, Wiebke; von Haeseler, Arndt; Zuber, Johannes; Ameres, Stefan L. (December 2017).
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and with contributions from the Austrian Government and the city of Vienna. The construction of the building was initiated in 2003 and completed in 2006. It is linked to the building of the
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Tavernini, Katherina; Papai, Nora; Hering, Steffen; Hofbauer, Pablo; Mendjan, Sasha (2022-09-01). "Multi-chamber cardioids unravel human heart development and cardiac defects".
653:. In 2012, Josef Penninger was awarded with the Innovator Award for his project "Novel Approaches to Breast Cancer Prevention and Inhibition of Metastases" through the 2047: 693: 1904: 227:: The Vienna Drosophila RNAi Center (VDRC) is located at IMBA, and is available to researchers worldwide. It collects an RNAi library of over 22,000 1711:
Kuba, Keiji; Imai, Yumiko; Rao, Shuan; Gao, Hong; Guo, Feng; Guan, Bin; Huan, Yi; Yang, Peng; Zhang, Yanli; Deng, Wei; Bao, Linlin (August 2005).
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Beyond the core scientific facilities of the institute, the IMBA laboratories are also financially supported to use of the core facilities of the
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by a bridge so as to enhance collaborations. Both institutes share a common canteen and their scientific core facilities. In 2002, the geneticist
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In collaboration with the incorporated society Dialog Gentechnik, in 2006 IMBA opened a hands-on biomolecular laboratory open to the public.
628: 608: 587:, former interim scientific director, has received the Young Investigator Award of the European Molecular Biology Organization (EMBO), the 1776: 2180: 2021: 2236: 2200: 1870: 512: 488: 380: 364: 120: 637:, former scientific director, has been elected as a full member of The Austrian Academy of Sciences (ÖAW). He has been awarded the 2241: 1927: 1900: 624: 578: 546: 441: 2120: 484:
seminars, and weekly guest lectures (termed "VBC lectures" and "Impromptus") from external, recognised or upcoming scientists.
650: 383:. In 2018, Josef Penninger was appointed as director of the Life Science Institute of the University of British Columbia and 256: 766: 565:
in 2017, highlighting Tanaka as "the leading expert in the field of regeneration biology". In 2018, she was awarded the
111:. The institute employs around 250 people from over 40 countries, who perform basic research. IMBA is located at the 592: 387:
took the position as interim director of IMBA. In 2020, the institute expanded in an additional building of the
2173: 612: 1953:"Press Release: Elly Tanaka and Jürgen Knoblich elected to the German National Academy of Sciences Leopoldina" 421: 329:. Development of a reversible haploid mouse pluripotent stem cell biobank resource for functional genomics. 2246: 620: 600: 570: 554: 550: 356: 347:. Discovery of the role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury. 150:
Stefan Ameres (adjunct group): Mechanism and biology of RNA silencing. Developer of the SLAMseq technology.
104: 59: 631:. In 2015, he was awarded both an Advanced and a Proof-of-concept European Research Council (ERC) grant. 1896: 480:
The IMBA acts as a forum for academic exchange through its participation to a series of weekly internal
429: 596: 566: 335:. Generation of cerebral organoids from human pluripotent stem cells to model human brain development 156:: Transposon silencing & heterochromatin formation by small RNAs. Pioneer in the discovery of the 2166: 741: 658: 532: 437: 654: 1713:"A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury" 65: 2210: 516: 417: 376: 116: 1838: 1095:"Amplification of human interneuron progenitors promotes brain tumors and neurological defects" 958: 409: 858: 1659: 1593: 1527: 1404: 1338: 1272: 1040: 908: 804: 604: 562: 379:, USA). In 2007 the Vienna Drosophila RNAi Center (VDRC) opened, in collaboration with the 360: 157: 124: 108: 1261:"A human tissue screen identifies a regulator of ER secretion as a brain-size determinant" 139:
processes underlying the 3D architecture of genomes, the functions of small RNAs, and the
8: 2097:"IMBA's Josef Penninger wins $ 7.4 million Innovator Award from US Department of Defense" 1516:"A reversible haploid mouse embryonic stem cell biobank resource for functional genomics" 646: 287: 205: 1814: 1663: 1597: 1531: 1408: 1342: 1276: 1044: 912: 808: 323:. Development of SLAM-Seq for the high-resolution assessment of RNA expression dynamics 191:
Sasha Mendjan: Molecular control of human cardiogenesis. Developer of the human cardiac
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focus of research conducted. As of December 2022, the IMBA SAB is chaired by
372: 1790: 1285: 1260: 1110: 1995: 1754: 1697: 1631: 1565: 1499: 1442: 1376: 1302: 1244: 1194: 1136: 1078: 1029:"A mitotic chromatin phase transition prevents perforation by microtubules" 1012: 936: 842: 433: 405: 1992:"Höchste Akademie-Preise für Neurowissenschafter, Biologen und Historiker" 717: 341:. Discovery of an endogenous small interfering RNA pathway in Drosophila. 317:. Generation of blood vessel organoids from human pluripotent stem cells. 538: 507:
is an international PhD training program carried out jointly by the four
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Nicolas Rivron: Blastoid development and implantation. Developer of the
1473: 665: 228: 661:’s (ERC) Advanced Investigator Grant for his research in the field of 115:(VBC) and shares facilities and scientific training programs with the 296:. Cardioids reveal self-organizing principles of human cardiogenesis 260: 252: 1219:"Cardioids reveal self-organizing principles of human cardiogenesis" 859:"Cardioids reveal self-organizing principles of human cardiogenesis" 211:
Shambaditya Saha: Macromolecular phase separation in germ cell fate.
103:) is an independent biomedical research organisation founded by the 2158: 1728: 1582:"Cerebral organoids model human brain development and microcephaly" 793:"Cerebral organoids model human brain development and microcephaly" 303: 278: 243: 192: 185: 163:
Alejandro Burga: Molecular determinants of biological idiosyncrasy.
26: 1393:"Human blood vessel organoids as a model of diabetic vasculopathy" 1327:"Conformation of sister chromatids in the replicated human genome" 1455: 662: 2048:"Wittgenstein-Preise 2009 an Jürgen Knoblich und Gerhard Widmer" 1871:"Elly Tanaka elected member of the Austrian Academy of Sciences" 1769:"Institute of Molecular Biotechnology (IMBA) | Vienna BioCenter" 1091: 641:
for Medicine by the Jung-Stiftung for Science and Research, the
2137: 1153:"Human blastoids model blastocyst development and implantation" 893: 355:
The institute was founded in 1999 as a joint initiative of the
1458:"Thiol-linked alkylation of RNA to assess expression dynamics" 1215: 855: 767:"Lexogen Launches SLAMseq Kit for Metabolic Sequencing of RNA" 172:
Anton Goloborodko: Theoretical models of chromosome structure.
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The institute comprises 14 research groups (as of July 2024):
78: 1512: 1257: 897:"Blastocyst-like structures generated solely from stem cells" 371:
started as the Scientific Director of the IMBA and recruited
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Joanna Jachowicz: Dark genome in early mammalian development.
619:, of the Mathematisch-naturwissenschaftlichen Klasse of the 302:. Identification of a brain-size determinant using cerebral 143:
reconstitution from stem cells of whole organs and embryos.
1648:"An endogenous small interfering RNA pathway in Drosophila" 1578: 1389: 1025: 981: 789: 574: 541:, current scientific director, was elected a member of the 184:: Brain development and disease. Developer of the cerebral 495:
focusing on the next generation of stem cell researchers.
492: 1928:"Elly Tanaka elected to the National Academy of Sciences" 175:
Sofia Grade: Mechanisms of plasticity after brain injury.
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for lifetime achievements. In 2020, she was awarded the
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Noelia Urbán: Systemic regulation of adult neurogenesis.
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The research at IMBA aims to understand the fundamental
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Gregor Mendel Institute of Molecular Plant Biology (GMI)
1149: 1644: 2014: 1967: 395:took the position as Scientific Director of IMBA. 217:: Molecular mechanisms of vertebrate regeneration. 531:TIMBA has received recognition in the form of 18 2228: 1839:"The Nobel Prize in Physiology or Medicine 2000" 627:(EMBO), and is on the board of directors of the 234: 107:in cooperation with the pharmaceutical company 1710: 657:. In 2013 Josef Penninger received his second 559:German National Academy of Sciences Leopoldina 535:grants and through awards to its researchers. 290:model blastocyst development and implantation 2174: 1932:The Research Institute of Molecular Pathology 1875:The Research Institute of Molecular Pathology 694:"Institute of Molecular Biotechnology (IMBA)" 459: 2130: 1926:Pathology, Research Institute of Molecular. 1869:Pathology, Research Institute of Molecular. 629:International Society for Stem Cell Research 609:Federation of European Biochemical Societies 398: 119:of the Austrian Academy of Sciences and the 1791:"Josef Penninger | Life Sciences Institute" 963:IMBA - Institute of Molecular Biotechnology 722:IMBA - Institute of Molecular Biotechnology 20:Institute of Molecular Biotechnology (IMBA) 2181: 2167: 475: 64: 1744: 1687: 1621: 1555: 1489: 1432: 1366: 1284: 1234: 1184: 1126: 1068: 870: 832: 381:Research Institute of Molecular Pathology 365:Research Institute of Molecular Pathology 121:Research Institute of Molecular Pathology 16:Austrian biomedical research organisation 951: 671: 649:and has received the Carus-Medal of the 1977:was invoked but never defined (see the 1855:was invoked but never defined (see the 764: 625:European Molecular Biology Organisation 611:(FEBS). He is an elected member of the 547:European Molecular Biology Organisation 2229: 1955:. Institute of Molecular Biotechnology 269:. Identification of CLIP cells (human 201:(guest group): Modeling human disease. 2162: 1925: 1868: 651:German Academy of Sciences Leopoldina 2216:Institute of Molecular Biotechnology 2188: 2002:from the original on 3 December 2018 169:: Chromosome sturcutre and dynamics. 123:(IMP), the basic research center of 97:Institute of Molecular Biotechnology 1972: 1850: 13: 1845: 375:as the first group leader (now at 251:. Disentanglement of the roles of 14: 2258: 1907:from the original on 19 June 2017 1894: 2237:Biochemistry research institutes 2201:Institute of Molecular Pathology 1973:Cite error: The named reference 1851:Cite error: The named reference 25: 2113: 2089: 2065: 2040: 2022:"Elly Tanaka receives the FEBS" 1984: 1945: 1919: 1888: 1862: 1831: 1807: 1783: 1761: 1704: 1638: 1572: 1506: 1449: 1383: 1317: 1251: 1209: 1143: 1085: 1019: 277:using patient-derived cerebral 2242:Research institutes in Austria 1897:"EMBO welcomes 65 new members" 975: 887: 849: 783: 758: 734: 710: 686: 613:Pontifical Academy of Sciences 505:Vienna Biocenter PhD Programme 498: 273:progenitors) as the origin of 1: 765:Lexogen (25 September 2017). 679: 561:in 2024. She was awarded the 438:European Research Council ERC 430:University of Paris Descartes 422:Cold Spring Harbor Laboratory 621:Austrian Academy of Sciences 601:Austrian Academy of Sciences 571:Austrian Academy of Sciences 555:National Academy of Sciences 551:Austrian Academy of Sciences 357:Austrian Academy of Sciences 242:. First multi-chamber heart 235:Major scientific discoveries 105:Austrian Academy of Sciences 60:Austrian Academy of Sciences 7: 1815:"Scientific Advisory Board" 259:in chromosome assembly and 130: 10: 2263: 2121:"ERC Advanced Grants 2013" 1236:10.1016/j.cell.2021.04.034 1169:10.1038/s41586-021-04267-8 1053:10.1038/s41586-022-05027-y 997:10.1016/j.cell.2023.10.030 460:Core scientific facilities 452:), and Nobel prize winner 410:The Rockefeller University 350: 208:, a complete embryo model. 2196: 1417:10.1038/s41586-018-0858-8 1351:10.1038/s41586-020-2744-4 921:10.1038/s41586-018-0051-0 872:10.1101/2020.07.06.189431 659:European Research Council 526: 399:Scientific Advisory Board 73: 53: 41: 33: 24: 655:US Department of Defense 591:awarded by the Austrian 581:Women in Science Award. 391:(termed VBC6). In 2024, 2211:Gregor Mendel Institute 1773:www.viennabiocenter.org 1286:10.1126/science.abb5390 1111:10.1126/science.abf5546 597:Erwin Schrödinger Prize 567:Erwin Schrödinger Prize 491:co-organize the yearly 476:Seminar and conferences 418:University of Cambridge 377:Janelia Research Campus 2073:"Oeaw Members Detail" 1229:(12): 3299–3317.e22. 865:: 2020.07.06.189431. 672:Science communication 511:research institutes ( 257:histone deacetylation 645:for Research by the 605:Sir Hans Krebs Medal 563:Ernst Schering Prize 361:Boehringer Ingelheim 137:molecular biological 125:Boehringer Ingelheim 109:Boehringer Ingelheim 2247:Education in Vienna 1998:. 3 December 2018. 1975:scheringstiftung.de 1672:10.1038/nature07007 1664:2008Natur.453..798C 1606:10.1038/nature12517 1598:2013Natur.501..373L 1540:10.1038/nature24027 1532:2017Natur.550..114E 1409:2019Natur.565..505W 1343:2020Natur.586..139M 1277:2020Sci...370..935E 1045:2022Natur.609..183S 913:2018Natur.557..106R 817:10.1038/nature12517 809:2013Natur.501..373L 647:European Commission 593:Ministry of Science 225:Associated projects 21: 2028:. 18 February 2020 1474:10.1038/nmeth.4435 1105:(6579): eabf5546. 589:Wittgenstein Award 450:Harvard University 436:(President of the 275:Tuberous Sclerosis 158:piRNA/Piwi pathway 19: 2224: 2223: 1658:(7196): 798–802. 1592:(7467): 373–379. 1526:(7674): 114–118. 1468:(12): 1198–1204. 1403:(7740): 505–510. 1337:(7827): 139–144. 1271:(6519): 935–941. 1163:(7894): 600–605. 1039:(7925): 183–190. 991:(25): 5587–5605. 907:(7703): 106–111. 803:(7467): 373–379. 742:"Research Groups" 617:Academia Europaea 543:Academia Europaea 493:SY-Stem symposium 93: 92: 2254: 2190:Vienna Biocenter 2183: 2176: 2169: 2160: 2159: 2153: 2152: 2150: 2149: 2134: 2128: 2127: 2125: 2117: 2111: 2110: 2108: 2107: 2093: 2087: 2086: 2084: 2083: 2069: 2063: 2062: 2060: 2059: 2044: 2038: 2037: 2035: 2033: 2018: 2012: 2011: 2009: 2007: 1988: 1982: 1976: 1971: 1965: 1964: 1962: 1960: 1949: 1943: 1942: 1940: 1938: 1923: 1917: 1916: 1914: 1912: 1892: 1886: 1885: 1883: 1881: 1866: 1860: 1854: 1849: 1843: 1842: 1835: 1829: 1828: 1826: 1825: 1811: 1805: 1804: 1802: 1801: 1787: 1781: 1780: 1775:. 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Index


Parent
Austrian Academy of Sciences
Edit this on Wikidata
www.imba.oeaw.ac.at
Austrian Academy of Sciences
Boehringer Ingelheim
Vienna BioCenter
Gregor Mendel Institute of Molecular Plant Biology (GMI)
Research Institute of Molecular Pathology
Boehringer Ingelheim
molecular biological
Julius Brennecke
piRNA/Piwi pathway
Daniel Gerlich
Jürgen Knoblich
organoid
organoid
Josef Penninger
blastoid
Elly Tanaka
Drosophila
organoids
condensin
histone deacetylation
chromatin
interneuron
Tuberous Sclerosis
organoids
blastoids

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