329:
29:
496:
589:
levels, depending on the used testing system. Specifically, glucose dehydrogenase pyrroloquinolinequinone (GDH-PQQ) or glucose-dye-oxidoreductase (GDO) based tests can erroneously show high blood glucose in patients that have been treated with icodextrin.
577:, and headache. Of these side effects, only hypertension and rashes occurred significantly more often than under glucose solution; the other events seem to be related to peritoneal dialysis in general.
747:
505:
When used for peritoneal dialysis, the icodextrin solution absorbs waste products from the blood, and is removed from the peritoneum after a few hours together with the waste.
476:
and its number-average molecular weight between 5,000 and 6,500 daltons. The substance is a white to off-white solid, and the solution is clear and colourless to pale yellow.
793:
740:
798:
73:
1089:
733:
382:
513:
Icodextrin is not significantly metabolised inside the peritoneum. Instead, it is absorbed slowly (40% after 12 hours) into the bloodstream via the
788:
41:
389:
403:
103:
525:. In patients with intact kidney function, both icodextrin and its fragments are excreted via the kidney by
248:
297:
308:
407:
606:
324:
201:
1120:
546:
725:
1115:
1063:
59:
566:
526:
650:
175:
827:
257:
671:
Frampton JE, Plosker GL (2003). "Icodextrin: a review of its use in peritoneal dialysis".
8:
1043:
1038:
1023:
993:
932:
861:
803:
499:
438:
426:
328:
166:
488:
for three to four days, separating tissues and thus reducing adhesion between them when
1048:
1003:
998:
957:
492:
is formed after a surgery. In other words, the tissues are kept from gluing together.
51:
1079:
1068:
1058:
1018:
1013:
952:
688:
684:
1028:
756:
680:
345:
119:
1008:
942:
897:
550:
518:
465:
137:
127:
86:
66:
1033:
947:
912:
851:
607:
American
College of Physicians--American Society of Internal Medicine (2005).
1109:
1053:
922:
902:
778:
586:
522:
473:
142:
1073:
856:
818:
813:
808:
760:
711:
692:
625:
570:
514:
434:
418:
81:
20:
441:(fibrous bands that form between tissues and organs) under the trade name
917:
866:
837:
562:
221:
927:
907:
871:
846:
823:
542:
485:
370:
232:
881:
186:
149:
45:
1084:
977:
967:
937:
876:
755:
537:
Icodextrin is contraindicated in patients with cornstarch allergy,
472:. Its weight-average molecular weight is between 13,000 and 19,000
277:
212:
28:
972:
962:
783:
538:
495:
484:
The osmotic activity of icodextrin keeps the solution inside the
469:
461:
458:
422:
414:
411:
1094:
489:
454:
288:
769:
154:
313:
574:
268:
651:"Adept (4% Icodextrin) Adhesion Reduction Solution"
1107:
200:
670:
174:
741:
464:linked by α-(1→4) and less than 10% α-(1→6)
706:
704:
702:
437:surgery for the reduction of post-surgical
111:In general: ℞ (Prescription only)
748:
734:
327:
27:
256:
699:
620:
618:
494:
323:
220:
1108:
479:
729:
645:
643:
641:
639:
615:
600:
296:
50:
532:
191:
85:
508:
276:
13:
636:
556:
457:-derived, branched, water-soluble
14:
1132:
685:10.2165/00003495-200363190-00011
611:. BMJ Pub. Group. p. 1046.
585:Icodextrin can mimic increased
580:
517:. There it is broken down into
664:
1:
994:Peritoneal dialysis solutions
593:
448:
7:
891:Irrigating solutions (B05C)
772:and related products (B05A)
609:Clinical evidence, Issue 14
10:
1137:
433:, and after gynecological
340:Chemical and physical data
986:
890:
836:
768:
759:and perfusion solutions (
379:
369:
344:
339:
307:
287:
267:
247:
231:
211:
185:
165:
160:
148:
136:
126:
118:
102:
97:
72:
58:
40:
35:
26:
561:Adverse effects include
547:glycogen storage disease
52:International Drug Names
1064:Sodium glycerophosphate
573:(high blood pressure),
794:Hemoglobin crosfumaril
502:
468:, making it a type of
567:respiratory infection
527:glomerular filtration
498:
429:under the trade name
421:, used in form of an
862:Protein hydrolysates
828:umbilical cord blood
417:agent, derived from
1044:Magnesium phosphate
1024:Potassium phosphate
987:Others (B05D, B05X)
933:Ethacridine lactate
804:Hydroxyethyl starch
799:Hemoglobin raffimer
500:Peritoneal dialysis
480:Mechanism of action
427:peritoneal dialysis
23:
16:Pharmaceutical drug
1049:Magnesium chloride
1004:Sodium bicarbonate
999:Potassium chloride
958:Sodium bicarbonate
503:
19:
1103:
1102:
1080:Potassium acetate
1069:Potassium lactate
1059:Hydrochloric acid
1019:Magnesium sulfate
1014:Ammonium chloride
953:Magnesium citrate
757:Blood substitutes
533:Contraindications
397:
396:
309:CompTox Dashboard
1128:
1090:Alanyl glutamine
1039:Sodium phosphate
1029:Calcium chloride
840:solutions (B05B)
750:
743:
736:
727:
726:
720:
719:
708:
697:
696:
679:(19): 2079–105.
668:
662:
661:
655:
647:
634:
633:
622:
613:
612:
604:
519:oligosaccharides
509:Pharmacokinetics
466:glycosidic bonds
453:Icodextrin is a
393:
392:
385:
332:
331:
317:
315:
300:
280:
260:
224:
204:
194:
193:
178:
89:
54:
31:
24:
22:
18:
1136:
1135:
1131:
1130:
1129:
1127:
1126:
1125:
1121:Polysaccharides
1106:
1105:
1104:
1099:
1009:Sodium chloride
982:
943:Sodium chloride
898:Cetylpyridinium
886:
852:Lipid emulsions
832:
764:
754:
724:
723:
710:
709:
700:
669:
665:
653:
649:
648:
637:
624:
623:
616:
605:
601:
596:
583:
559:
557:Adverse effects
551:lactic acidosis
535:
511:
482:
451:
388:
386:
383:(what is this?)
380:
365:
361:
357:
353:
335:
311:
303:
283:
263:
243:
227:
207:
190:
181:
132:40% in 12 hours
128:Bioavailability
120:Pharmacokinetic
114:
93:
67:Intraperitoneal
61:
17:
12:
11:
5:
1134:
1124:
1123:
1118:
1116:Renal dialysis
1101:
1100:
1098:
1097:
1092:
1087:
1082:
1077:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1034:Sodium acetate
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
990:
988:
984:
983:
981:
980:
975:
970:
965:
960:
955:
950:
948:Sodium citrate
945:
940:
935:
930:
925:
920:
915:
913:Sulfamethizole
910:
905:
900:
894:
892:
888:
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879:
874:
869:
864:
859:
854:
849:
843:
841:
834:
833:
831:
830:
821:
816:
811:
806:
801:
796:
791:
789:Gelatin agents
786:
781:
775:
773:
766:
765:
753:
752:
745:
738:
730:
722:
721:
698:
663:
635:
614:
598:
597:
595:
592:
582:
579:
558:
555:
534:
531:
521:by the enzyme
510:
507:
481:
478:
450:
447:
395:
394:
377:
376:
373:
367:
366:
363:
359:
355:
351:
348:
342:
341:
337:
336:
334:
333:
325:DTXSID70872514
320:
318:
305:
304:
302:
301:
293:
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284:
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273:
271:
265:
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261:
253:
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241:
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94:
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78:
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69:
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62:administration
56:
55:
48:
38:
37:
33:
32:
15:
9:
6:
4:
3:
2:
1133:
1122:
1119:
1117:
1114:
1113:
1111:
1096:
1093:
1091:
1088:
1086:
1083:
1081:
1078:
1075:
1072:
1070:
1067:
1065:
1062:
1060:
1057:
1055:
1054:Zinc chloride
1052:
1050:
1047:
1045:
1042:
1040:
1037:
1035:
1032:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1007:
1005:
1002:
1000:
997:
995:
992:
991:
989:
985:
979:
976:
974:
971:
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966:
964:
961:
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954:
951:
949:
946:
944:
941:
939:
936:
934:
931:
929:
926:
924:
923:Mandelic acid
921:
919:
916:
914:
911:
909:
906:
904:
903:Chlorhexidine
901:
899:
896:
895:
893:
889:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
857:Carbohydrates
855:
853:
850:
848:
845:
844:
842:
839:
835:
829:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
779:Serum albumin
777:
776:
774:
771:
767:
762:
758:
751:
746:
744:
739:
737:
732:
731:
728:
717:
713:
707:
705:
703:
694:
690:
686:
682:
678:
674:
667:
659:
652:
646:
644:
642:
640:
631:
627:
621:
619:
610:
603:
599:
591:
588:
587:blood glucose
578:
576:
572:
568:
564:
554:
552:
548:
545:intolerance,
544:
540:
530:
528:
524:
523:alpha-amylase
520:
516:
515:lymph vessels
506:
501:
497:
493:
491:
487:
477:
475:
471:
467:
463:
460:
456:
446:
444:
440:
436:
432:
428:
425:solution for
424:
420:
416:
413:
409:
405:
401:
391:
384:
378:
374:
372:
368:
349:
347:
343:
338:
330:
326:
322:
321:
319:
310:
306:
299:
298:ChEMBL1201472
295:
294:
292:
290:
286:
279:
275:
274:
272:
270:
266:
259:
255:
254:
252:
250:
246:
239:
238:
236:
234:
230:
223:
219:
218:
216:
214:
210:
203:
199:
198:
196:
188:
184:
177:
173:
172:
170:
168:
164:
159:
156:
153:
151:
147:
144:
143:Alpha-amylase
141:
139:
135:
131:
129:
125:
121:
117:
110:
109:
107:
105:
101:
96:
88:
83:
80:
79:
77:
75:
71:
68:
65:
63:
57:
53:
49:
47:
43:
39:
36:Clinical data
34:
30:
25:
1074:Cardioplegia
867:Electrolytes
819:Blood plasma
814:Thrombocytes
809:Erythrocytes
715:
676:
672:
666:
657:
629:
608:
602:
584:
581:Interactions
571:hypertension
560:
549:, or severe
536:
512:
504:
483:
452:
442:
435:laparoscopic
430:
419:maltodextrin
399:
398:
387:
381:
375:13–19 kg/mol
104:Legal status
98:Legal status
918:Taurolidine
847:Amino acids
838:Intravenous
712:"Extraneal"
626:"Extraneal"
563:peritonitis
176:337376-15-5
161:Identifiers
1110:Categories
928:Noxytiolin
908:Nitrofural
872:Trometamol
824:Stem cells
630:RxList.com
594:References
543:isomaltose
486:peritoneum
400:Icodextrin
371:Molar mass
258:2NX48Z0A9G
233:ChemSpider
167:CAS Number
138:Metabolism
21:Icodextrin
1076:solutions
882:Carbamide
716:Drugs.com
449:Chemistry
439:adhesions
431:Extraneal
150:Excretion
60:Routes of
46:Drugs.com
1085:Arginine
978:Mannitol
968:Sorbitol
938:Neomycin
877:Mannitol
693:12962523
390:(verify)
213:DrugBank
202:17397419
74:ATC code
973:Glycine
963:Glucose
784:Dextran
539:maltose
474:daltons
470:dextrin
462:polymer
459:glucose
423:aqueous
415:osmotic
412:colloid
410:) is a
346:Formula
222:DB00702
187:PubChem
90:)
84: (
1095:Lysine
691:
575:rashes
490:fibrin
455:starch
289:ChEMBL
278:D03266
189:
826:from
770:Blood
673:Drugs
654:(PDF)
443:Adept
155:Renal
82:B05DA
689:PMID
408:USAN
269:KEGG
249:UNII
240:none
122:data
42:AHFS
761:B05
681:doi
658:FDA
541:or
404:INN
314:EPA
192:SID
87:WHO
1112::
714:.
701:^
687:.
677:63
675:.
656:.
638:^
628:.
617:^
569:,
565:,
553:.
529:.
445:.
406:,
356:10
350:(C
763:)
749:e
742:t
735:v
718:.
695:.
683::
660:.
632:.
402:(
364:n
362:)
360:5
358:O
354:H
352:6
316:)
312:(
44:/
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
