364:
247:
33:
24:
500:
843:
Many myeloblastosis (MYB) transcription factors have been identified in a variety of fruits and plants, including strawberries, maize, and arabidopsis, as being important in the regulation of flavonoid biosynthesis and accumulation. These transcription factors continue to be studied in plant model organisms such as maize and
Arabidopsis.
846:
The environment of the plant has also been shown to affect the flavonoid biosynthesis pathway. Shorter wavelengths of light, ranging from blue to UV light, allow for higher production and accumulation of flavonoids in fruits. These wavelengths activate enzymes that are involved in the phenylpropanoid
842:
Flavonoid biosynthesis gene regulation occurs through the interaction of different transcription factors. Depending on the combination of transcription factor interactions, the structural genes involved in flavonoid biosynthesis are expressed in specific locations of the plant and at specific times.
859:
and has been shown in laboratory studies to extend the life of yeast, worms, flies, and mice. Like the other compounds, it has also been shown to be reactive in many different assays of biological activities, raising the possibility that any drug generated from fisetin would have too many side
1436:
Viñas, P.; MartĂnez-Castillo, N.; Campillo, N.; Hernández-CĂłrdoba, M. (2011). "Directly suspended droplet microextraction with in injection-port derivatization coupled to gas chromatography–mass spectrometry for the analysis of polyphenols in herbal infusions, fruits and functional foods".
985:
Medical research on humans is at a very early stage, and health claims are therefore not well supported. In vitro results or animal studies may and often do seriously differ from actual performance in human metabolism observed in double blind randomized reviewed studies.
1774:
Yousefzadeh, Matthew J.; Zhu, Yi; McGowan, Sara J.; Angelini, Luise; Fuhrmann-Stroissnigg, Heike; Xu, Ming; Ling, Yuan Yuan; Melos, Kendra I.; Pirtskhalava, Tamar; Inman, Christina L.; McGuckian, Collin (2018-10-01).
2017:
Salerno, S.; Da
Settimo, F.; Taliani, S.; Simorini, F.; La Motta, C.; Fornaciari, G.; Marini, A. M. (2010). "Recent advances in the development of dual topoisomerase I and II inhibitors as anticancer drugs".
838:
help control changes in the flavonoid's solubility and reactivity by catalyzing the addition of things such as methyl groups and sugars. This allows for controlled fluctuations in physiological activities.
963:
in the cell membrane. Like other flavonoids, it has a planar structure, with multiple carbon rings. It scavenges free radicals as a result of its electron-donating capacity, due to the presence of two
2625:
2590:
2585:
1472:
De Santi, C.; Pietrabissa, A.; Mosca, F.; Pacifici, G. M. (2002). "Methylation of quercetin and fisetin, flavonoids widely distributed in edible vegetables, fruits and wine, by human liver".
555:
colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers. Its chemical formula was first described by
Austrian chemist
2341:
Salmela, Anna-Leena; Pouwels, Jeroen; Varis, Asta; Kukkonen, Anu M.; Toivonen, Pauliina; Halonen, Pasi K.; Perälä, Merja; Kallioniemi, Olli; Gorbsky, Gary J.; Kallio, Marko J. (2009).
2595:
2692:
2053:
Yousefzadeh, Matthew J.; Zhu, Yi; McGowan, Sara J.; Angelini, Luise; Fuhrmann-Stroissnigg, Heike; Xu, Ming; Ling, Yuan Yuan; Melos, Kendra I.; Pirtskhalava, Tamar (2018-09-29).
2734:
2729:
897:
agent in wild-type mice, with effects of increased lifespan, reduced senescence markers in tissues, and reduced age-related pathologies. Studies of cell cultures of senescent
3044:
2610:
3081:
3050:
2681:
1394:"Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration"
3055:
2605:
1059:
Sahu, Bidya Dhar; Kalvala, Anil Kumar; Koneru, Meghana; Kumar, Jerald Mahesh; Kuncha, Madhusudana; Rachamalla, Shyam Sunder; Sistla, Ramakrishna (September 3, 2014).
3113:
2804:
2620:
2615:
3103:
2635:
2630:
3333:
2651:
3155:
834:). The activity of different enzymes, including isomerases and hydroxylases, alter the backbone depending on the subclass of the flavonoid being produced.
3186:
144:
513:
3269:
3265:
3261:
1346:"It's not an apple a day after all -- it's strawberries: Flavonoids could represent two-fisted assault on diabetes and nervous system disorders"
3150:
847:
and flavonoid biosynthesis pathways, stimulating the production of flavonoids. The level of stimulation can vary between individual fruits.
3181:
3109:
3077:
413:
3040:
2821:
2542:
1982:
Gupta, SC; et al. (1 October 2014). "Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols".
2771:
2677:
1061:"Ameliorative Effect of Fisetin on Cisplatin-Induced Nephrotoxicity in Rats via Modulation of NF-ÎşB Activation and Antioxidant Defence"
1509:"Comparison of the main components and bioactivity of Rhus verniciflua Stokes extracts by different detoxification processing methods"
3191:
1292:
Maher, Pamela; Dargusch, Richard; Ehren, Jennifer L.; Okada, Shinichi; Sharma, Kumar; Schubert, David (2011). Deli, Maria A. (ed.).
3099:
863:
Fisetin has shown anti-cancer activity in studies on cells and model animals conducted in laboratories, and appears to block the
982:
Manufacturers, promoters and sellers of fisetin dietary supplements make various claims of supposed health benefits for humans.
898:
265:
2215:"Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women - Full Text View - ClinicalTrials.gov"
1669:
2408:
3343:
1161:
378:
508:
520:
1253:"Dietary flavonoids as intracellular substrates for an erythrocyte trans-plasma membrane oxidoreductase activity"
830:
from 4-coumaroyl-CoA. All flavonoids are derived from this chalcone backbone (this family being the so-called
2799:
55:
2116:
890:, which may turn out to be a carcinogenic activity or an anti-cancer activity; further research is needed.
321:
242:
2343:"Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint"
917:
912:
In studies conducted on cells in a laboratory, fisetin inhibits the activity of several pro-inflammatory
856:
342:
184:
686:
2646:
2687:
2600:
1294:"Fisetin Lowers Methylglyoxal Dependent Protein Glycation and Limits the Complications of Diabetes"
875:
359:
2401:
1345:
952:
909:. A clinical trial in the U.S. was under way as of October 2018 to show effectiveness in humans.
887:
1930:
1507:
Lee, Seon-Ok; Kim, Sung-Ji; Kim, Ju-Sung; Ji, Hyuk; Lee, Eun-Ok; Lee, Hyo-Jeong (2021-06-02).
2724:
864:
606:
387:
InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
204:
45:
397:
InChI=1/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
3296:
3171:
1305:
1207:
1072:
933:
330:
2163:"Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies"
8:
2872:
1012:
1008:"Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies"
563:
120:
110:
1691:
1664:
1309:
1211:
1076:
363:
246:
164:
3348:
3338:
2982:
2394:
2367:
2342:
2318:
2293:
2262:
2235:
2191:
2162:
2138:
2111:
2087:
2054:
1954:
1925:
1901:
1876:
1811:
1776:
1751:
1726:
1704:
1640:
1613:
1612:
Zoratti, L.; Karppinen, K.; Escobar, A.L.; Haggman, H.; Jaakola, L. (October 9, 2014).
1589:
1562:
1535:
1508:
1328:
1293:
1233:
1139:
1095:
1060:
1036:
1007:
635:
616:
594:
901:
have shown that fisetin induces apoptosis by inhibition of the anti-apoptotic protein
646:
apples, and grapes. Fisetin can be extracted from fruit and herbal sources in juices,
3002:
2372:
2323:
2267:
2196:
2167:
2143:
2092:
2074:
2035:
1999:
1959:
1906:
1857:
1816:
1798:
1756:
1696:
1645:
1594:
1540:
1489:
1454:
1415:
1333:
1274:
1225:
1143:
1100:
1041:
823:
1708:
310:
23:
2491:
2436:
2362:
2354:
2313:
2305:
2257:
2247:
2186:
2176:
2133:
2125:
2082:
2066:
2027:
1991:
1949:
1939:
1896:
1888:
1847:
1806:
1788:
1746:
1738:
1686:
1678:
1635:
1625:
1584:
1574:
1563:"Flavanoids: biosynthesis, biological functions, and biotechnological applications"
1530:
1520:
1481:
1446:
1405:
1323:
1313:
1264:
1237:
1215:
1198:
1131:
1090:
1080:
1031:
1021:
436:
2214:
1665:"Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells"
3218:
2907:
2386:
1892:
1742:
1450:
1392:
Arai, Y.; Watanabe, S.; Kimira, M.; Shimoi, K.; Mochizuki, R.; Kinae, N. (2000).
1318:
1085:
819:
811:
2070:
1793:
2031:
1836:"How should we assess the effects of exposure to dietary polyphenols in vitro?"
1435:
956:
948:
663:
600:
588:
491:
1995:
1682:
1525:
3327:
3118:
2573:
2501:
2252:
2078:
1802:
1167:. Texas A&M Agricultural Research and Extension Center at. Archived from
921:
815:
651:
611:
579:
479:
235:
2358:
2181:
1926:"Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential"
1630:
1579:
1410:
1393:
3017:
2962:
2937:
2902:
2787:
2376:
2327:
2271:
2200:
2147:
2096:
2039:
2003:
1963:
1910:
1861:
1852:
1835:
1820:
1760:
1700:
1649:
1598:
1544:
1493:
1458:
1419:
1337:
1278:
1229:
1104:
1045:
835:
556:
2309:
1168:
1026:
3301:
2952:
2947:
2922:
2827:
2793:
2775:
2765:
2761:
944:
929:
567:
1944:
1269:
224:
3306:
3012:
3007:
2987:
2972:
2957:
2897:
2833:
2809:
2781:
2750:
2697:
2567:
2553:
2529:
2486:
2481:
2476:
2129:
1135:
879:
831:
822:. This is the compound that enters the flavonoid biosynthesis pathway.
807:
736:
696:
643:
548:
459:
255:
195:
1220:
1193:
1005:
3093:
2997:
2992:
2977:
2932:
2927:
2912:
2892:
2887:
2877:
2709:
2669:
2537:
2511:
2506:
2496:
2451:
1485:
937:
913:
906:
894:
883:
868:
803:
756:
716:
659:
627:
544:
1119:
490:
Except where otherwise noted, data are given for materials in their
3245:
2942:
2657:
2579:
2471:
1877:"Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin"
1252:
964:
827:
776:
583:
540:
536:
285:
215:
78:
32:
1122:[Studies on Quercetin and its Derivatives, Treatise VII].
925:
566:
of fisetin has been studied in many laboratory assays; like other
143:
3176:
3087:
3071:
2917:
2756:
2640:
2561:
2161:
Wyld L, Bellantuono I, Tchkonia T, Danson S, Kirkland JL (2020).
971:
578:
Fisetin can be found in a wide variety of plants. It is found in
469:
297:
2016:
1471:
2967:
2882:
2055:"Fisetin is a senotherapeutic that extends health and lifespan"
1777:"Fisetin is a senotherapeutic that extends health and lifespan"
1474:
International
Journal of Clinical Pharmacology and Therapeutics
960:
902:
786:
746:
175:
1834:
Kroon, PA; Clifford, MN; Crozier, A; et al. (July 2004).
1611:
642:). Many fruits and vegetables also contain fisetin, including
551:. It can be found in many plants, where it serves as a yellow/
2815:
2160:
2052:
1773:
1731:
Biochimica et
Biophysica Acta (BBA) - Proteins and Proteomics
1561:
Ferreyra, M.L.; Rius, S.P.; Casati, P. (September 28, 2012).
766:
726:
706:
655:
552:
155:
133:
1120:"Studien ĂĽber Quercetin und seine Derivate, VII. Abhandlung"
347:
2340:
2233:
647:
630:, fisetin provides the color of the traditional yellow dye
622:
276:
1006:
RodrĂguez-GarcĂa C, Sánchez-Quesada C, Gaforio JJ (2019).
2236:"SIRT1 Activation by Natural Phytochemicals: An Overview"
947:, an endogenous antioxidant. It has direct activity as a
1391:
1291:
1500:
1058:
955:
to neutralize them. Studies suggest that it lodges in
2294:"Fisetin: a dietary antioxidant for health promotion"
1923:
905:. Fisetin has roughly twice the senolytic potency as
2292:
Khan, N; Syed, DN; Ahmad, N; Mukhtar, H (Jul 2013).
2291:
1833:
967:
groups on one ring and a hydroxyl group on another.
943:
Fisetin has been shown in lab studies to upregulate
1614:"Light-controlled flavanoid biosynthesis in fruits"
1556:
1554:
264:
2416:
2234:Iside C, Scafuro M, Nebbioso A, Altucci L (2020).
1977:
1975:
1973:
1560:
1159:
650:, and infusions such as teas. It is also found in
73:2-(3,4-Dihydroxyphenyl)-3,7-dihydroxychromen-4-one
1194:"Antibacterial Effect of Fisetin and Fisetinidin"
3325:
2112:"Senolytic drugs: from discovery to translation"
2109:
1551:
970:In vitro screening has identified fisetin as an
928:(NF-ÎşB). The anti-inflammatory action is due to
309:
1970:
1387:
1385:
1383:
1381:
874:In lab studies fisetin has been shown to be an
810:subgroup. Flavonoid synthesis begins with the
119:
2287:
2285:
2283:
2281:
2010:
1924:Kashyap D, Garg VK, Tuli HS, Sandhu S (2019).
1868:
1720:
1718:
1431:
1429:
1379:
1377:
1375:
1373:
1371:
1369:
1367:
1365:
1363:
1361:
1250:
1191:
1001:
999:
871:activation, and prevent apoptosis resistance.
2402:
826:, the first enzyme of this pathway, produces
2227:
2154:
2103:
1917:
1827:
1656:
1465:
3334:17β-Hydroxysteroid dehydrogenase inhibitors
2278:
1715:
1506:
1426:
1358:
996:
886:, it has been found in lab studies to be a
2643:(kaempferol-3-O-robinoside-7-O-rhamnoside)
2409:
2395:
1513:BMC Complementary and Alternative Medicine
893:Fisetin has been shown to be an effective
362:
245:
203:
2366:
2317:
2261:
2251:
2190:
2180:
2137:
2086:
1953:
1943:
1900:
1851:
1810:
1792:
1750:
1727:"Biochemical effects of SIRT1 activators"
1690:
1662:
1639:
1629:
1588:
1578:
1534:
1524:
1409:
1327:
1317:
1268:
1219:
1094:
1084:
1052:
1035:
1025:
977:
582:, such as trees and shrubs in the family
421:O=C1c3c(O/C(=C1/O)c2ccc(O)c(O)c2)cc(O)cc3
329:
2836:(galloylated 3-O-glucoside of quercetin°
1285:
1162:"Chemistry of Acacia's from South Texas"
867:, along with other mechanisms to induce
626:, which contains the sumacs. Along with
2626:Kaempferol 7-O-alpha-L-rhamnofuranoside
1984:Archives of Biochemistry and Biophysics
358:
223:
60:2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4
3326:
2591:Kaempferol 3-alpha-D-arabinopyranoside
2586:Kaempferol 3-alpha-L-arabinopyranoside
1155:
1153:
1117:
899:human umbilical vein endothelial cells
850:
484:330 °C (626 °F; 603 K)
236:
2753:(quercetin-3-O-α-L-arabinofuranoside)
2390:
1981:
818:, an amino acid, is transformed into
573:
390:Key: XHEFDIBZLJXQHF-UHFFFAOYSA-N
183:
163:
1874:
1724:
1670:Cellular and Molecular Life Sciences
2660:(Kaempferol 3-O-beta-D-galactoside)
1150:
400:Key: XHEFDIBZLJXQHF-UHFFFAOYAQ
300:
284:
13:
2298:Antioxidants & Redox Signaling
1875:Syed, DN; et al. (Sep 2013).
14:
3360:
1251:Fiorani, M.; Accorsi, A. (2005).
1192:Gábor, M.; Eperjessy, E. (1966).
959:and prevents oxidative damage to
882:in several ways. Like some other
2596:Kaempferol 7-alpha-L-arabinoside
2110:Kirkland JL, Tchkonia T (2020).
1257:The British Journal of Nutrition
498:
31:
22:
2334:
2207:
2046:
1767:
1605:
1352:(Press release). June 28, 2011.
797:
634:, which was extracted from the
494:(at 25 °C , 100 kPa).
3074:(Azaleatin 3-O-α-L-rhamnoside)
2693:Myricetin-3-O-neohesperidoside
2417:Flavonols and their conjugates
1244:
1185:
1111:
1:
2576:(kaempferol 3,7-dirhamnoside)
989:
49:3,3′,4′,7-Tetrahydroxyflavone
3096:(Eupatolitin 3-O-rhamnoside)
2654:(Kaempferol 3-O-sophoroside)
2582:(Kaempferol 3-O-arabinoside)
2117:Journal of Internal Medicine
1893:10.2174/18715206113139990129
1743:10.1016/j.bbapap.2009.10.025
1451:10.1016/j.chroma.2010.12.026
1319:10.1371/journal.pone.0021226
1086:10.1371/journal.pone.0105070
464:286.2363 g/mol
7:
3045:Isorhamnetin 3-O-rutinoside
2796:(quercetin 3-O-glucuronide)
2784:(quercetin 3-O-galactoside)
2439:(synthetic) and derivatives
2071:10.1016/j.ebiom.2018.09.015
1794:10.1016/j.ebiom.2018.09.015
1439:Journal of Chromatography A
951:, chemically reacting with
918:tumor necrosis factor alpha
857:sirtuin-activating compound
10:
3365:
3090:(Eupalitin 3-0-rhamnoside)
3082:Centaureidin 7-O-glucoside
3051:Isorhamnetin 3-O-glucoside
2830:(quercetin 4'-O-glucoside)
2812:(quercetin 3-O-rhamnoside)
2800:Quercetin 3,4'-diglucoside
2790:(quercetin 3-O-glucoside)
2700:(Myricetin 3-O-rhamnoside)
2570:(kaempferol 3-O-glucoside)
2032:10.2174/092986710793361252
1881:Anticancer Agents Med Chem
1663:Hwang ES, Song SB (2017).
1618:Frontiers in Plant Science
1567:Frontiers in Plant Science
687:Toxicodendron vernicifluum
3289:
3282:
3254:
3238:
3231:
3211:
3204:
3164:
3143:
3136:
3064:
3033:
3026:
2865:
2855:
2743:
2735:Quercetin 3,4'-bissulfate
2730:Quercetin 3,3'-bissulfate
2717:
2707:
2682:Myricetin 3-O-arabinoside
2667:
2647:Kaempferol 3-O-rutinoside
2564:(Kaempferol 3-rhamnoside)
2551:
2527:
2520:
2459:
2450:
2429:
2422:
2240:Frontiers in Pharmacology
1996:10.1016/j.abb.2014.06.006
1683:10.1007/s00018-017-2527-8
1526:10.1186/s12906-018-2310-x
668:Callitropsis nootkatensis
620:and species of the genus
610:), members of the family
488:
429:
409:
374:
103:
77:(not to be confused with
70:
54:
44:
39:
30:
21:
3344:Topoisomerase inhibitors
3056:Tamarixetin 7-rutinoside
2824:(quercetin-3-D-xyloside)
2688:Myricetin 3-O-rutinoside
2611:Kaempferol 4'-rhamnoside
2606:Kaempferol 3-lathyroside
2601:Kaempferol 7-O-glucoside
2253:10.3389/fphar.2020.01225
1725:Baur, JA (August 2010).
1398:The Journal of Nutrition
1160:Forbes TDA, Clement BA.
932:of the pro-inflammatory
876:anti-proliferative agent
658:. It is also present in
570:it has many activities.
3114:Patuletin 7-O-glucoside
2805:Quercetin-3-sophorodide
2621:Kaempferol 7-rhamnoside
2616:Kaempferol 5-rhamnoside
2182:10.3390/cancers12082134
1631:10.3389/fpls.2014.00534
1580:10.3389/fpls.2012.00222
953:reactive oxygen species
888:topoisomerase inhibitor
878:, interfering with the
3104:Jaceidin 7-O-glucoside
2818:(quercetin rutinoside)
1124:Monatshefte fĂĽr Chemie
978:Health benefits claims
926:nuclear factor kappa B
860:effects to be useful.
586:, such as the acacias
3297:Hydroxyethylrutosides
3121:(Rhamnetin glycoside)
2859:-Methylated flavonols
2725:Quercetin 3-O-sulfate
2636:Kaempferol 7-xyloside
2631:Kaempferol 3-xyloside
2359:10.1093/carcin/bgp101
2310:10.1089/ars.2012.4901
1411:10.1093/jn/130.9.2243
1027:10.3390/antiox8050137
865:PI3K/AKT/mTOR pathway
607:Gleditsia triacanthos
604:), the honey locust (
56:Systematic IUPAC name
3137:Derivative flavonols
2652:Sophoraflavonoloside
1853:10.1093/ajcn/80.1.15
934:transcription factor
662:species such as the
2873:5-O-methylmyricetin
1945:10.3390/biom9050174
1310:2011PLoSO...621226M
1270:10.1079/bjn20051504
1212:1966Natur.212.1273G
1118:Herzig, J. (1891).
1077:2014PLoSO...9j5070S
851:Biological activity
598:, the parrot tree (
564:biological activity
64:-1-benzopyran-4-one
18:
3156:Dihydronoricaritin
2130:10.1111/joim.13141
1136:10.1007/BF01538594
814:pathway, in which
636:Eurasian smoketree
617:Quebracho colorado
595:Acacia berlandieri
574:Biological sources
521:Infobox references
16:
3321:
3320:
3317:
3316:
3278:
3277:
3227:
3226:
3200:
3199:
3187:Dihydrophelloside
3132:
3131:
3128:
3127:
2851:
2850:
2847:
2846:
2843:
2842:
2446:
2445:
1840:Am. J. Clin. Nutr
1677:(18): 3347–3362.
1221:10.1038/2121273a0
824:Chalcone synthase
795:
794:
679:Amount of Fisetin
529:Chemical compound
527:
526:
343:CompTox Dashboard
145:Interactive image
82:
3356:
3287:
3286:
3236:
3235:
3209:
3208:
3141:
3140:
3031:
3030:
2863:
2862:
2715:
2714:
2525:
2524:
2457:
2456:
2437:3-Hydroxyflavone
2427:
2426:
2411:
2404:
2397:
2388:
2387:
2381:
2380:
2370:
2353:(6): 1032–1040.
2338:
2332:
2331:
2321:
2289:
2276:
2275:
2265:
2255:
2231:
2225:
2224:
2222:
2221:
2211:
2205:
2204:
2194:
2184:
2158:
2152:
2151:
2141:
2107:
2101:
2100:
2090:
2050:
2044:
2043:
2014:
2008:
2007:
1979:
1968:
1967:
1957:
1947:
1921:
1915:
1914:
1904:
1872:
1866:
1865:
1855:
1831:
1825:
1824:
1814:
1796:
1771:
1765:
1764:
1754:
1722:
1713:
1712:
1694:
1660:
1654:
1653:
1643:
1633:
1609:
1603:
1602:
1592:
1582:
1558:
1549:
1548:
1538:
1528:
1504:
1498:
1497:
1486:10.5414/cpp40207
1469:
1463:
1462:
1433:
1424:
1423:
1413:
1404:(9): 2243–2250.
1389:
1356:
1353:
1341:
1331:
1321:
1289:
1283:
1282:
1272:
1248:
1242:
1241:
1223:
1189:
1183:
1182:
1180:
1179:
1173:
1166:
1157:
1148:
1147:
1115:
1109:
1108:
1098:
1088:
1056:
1050:
1049:
1039:
1029:
1003:
673:
672:
511:
505:
502:
501:
437:Chemical formula
367:
366:
351:
349:
333:
313:
302:
288:
268:
249:
238:
227:
207:
187:
167:
147:
123:
84:5-Deoxyquercetin
76:
35:
26:
19:
15:
3364:
3363:
3359:
3358:
3357:
3355:
3354:
3353:
3324:
3323:
3322:
3313:
3274:
3250:
3232:Furanoflavonols
3223:
3219:Karanjachromene
3205:Pyranoflavonols
3196:
3160:
3124:
3060:
3034:of isorhamnetin
3022:
2908:Chrysosplenetin
2839:
2774:(quercetin 3-di
2764:(quercetin 3-O-
2739:
2703:
2663:
2547:
2516:
2442:
2418:
2415:
2385:
2384:
2339:
2335:
2290:
2279:
2232:
2228:
2219:
2217:
2213:
2212:
2208:
2159:
2155:
2108:
2104:
2051:
2047:
2026:(35): 4270–90.
2015:
2011:
1980:
1971:
1922:
1918:
1887:(7): 995–1001.
1873:
1869:
1832:
1828:
1772:
1768:
1723:
1716:
1661:
1657:
1610:
1606:
1559:
1552:
1505:
1501:
1470:
1466:
1434:
1427:
1390:
1359:
1344:
1290:
1286:
1249:
1245:
1190:
1186:
1177:
1175:
1174:on May 15, 2011
1171:
1164:
1158:
1151:
1116:
1112:
1057:
1053:
1004:
997:
992:
980:
853:
820:4-coumaroyl-CoA
812:phenylpropanoid
800:
680:
576:
530:
523:
518:
517:
516: ?)
507:
503:
499:
495:
453:
449:
445:
439:
425:
422:
417:
416:
405:
402:
401:
398:
392:
391:
388:
382:
381:
370:
352:
345:
336:
316:
303:
291:
271:
258:
230:
210:
190:
170:
150:
137:
126:
113:
99:
97:
95:
93:
91:
89:
87:
85:
83:
74:
66:
65:
50:
12:
11:
5:
3362:
3352:
3351:
3346:
3341:
3336:
3319:
3318:
3315:
3314:
3312:
3311:
3310:
3309:
3304:
3293:
3291:
3284:
3280:
3279:
3276:
3275:
3273:
3272:
3258:
3256:
3252:
3251:
3249:
3248:
3242:
3240:
3233:
3229:
3228:
3225:
3224:
3222:
3221:
3215:
3213:
3206:
3202:
3201:
3198:
3197:
3195:
3194:
3189:
3184:
3179:
3174:
3168:
3166:
3162:
3161:
3159:
3158:
3153:
3147:
3145:
3138:
3134:
3133:
3130:
3129:
3126:
3125:
3123:
3122:
3116:
3107:
3097:
3091:
3085:
3075:
3068:
3066:
3062:
3061:
3059:
3058:
3053:
3048:
3037:
3035:
3028:
3024:
3023:
3021:
3020:
3015:
3010:
3005:
3000:
2995:
2990:
2985:
2980:
2975:
2970:
2965:
2960:
2955:
2950:
2945:
2940:
2935:
2930:
2925:
2920:
2915:
2910:
2905:
2900:
2895:
2890:
2885:
2880:
2875:
2869:
2867:
2860:
2853:
2852:
2849:
2848:
2845:
2844:
2841:
2840:
2838:
2837:
2831:
2825:
2819:
2813:
2807:
2802:
2797:
2791:
2785:
2779:
2769:
2759:
2754:
2747:
2745:
2741:
2740:
2738:
2737:
2732:
2727:
2721:
2719:
2712:
2708:Conjugates of
2705:
2704:
2702:
2701:
2695:
2690:
2685:
2674:
2672:
2668:Glycosides of
2665:
2664:
2662:
2661:
2655:
2649:
2644:
2638:
2633:
2628:
2623:
2618:
2613:
2608:
2603:
2598:
2593:
2588:
2583:
2577:
2571:
2565:
2558:
2556:
2552:Glycosides of
2549:
2548:
2546:
2545:
2540:
2534:
2532:
2528:Glycosides of
2522:
2518:
2517:
2515:
2514:
2509:
2504:
2499:
2494:
2489:
2484:
2479:
2474:
2469:
2463:
2461:
2454:
2448:
2447:
2444:
2443:
2441:
2440:
2433:
2431:
2424:
2420:
2419:
2414:
2413:
2406:
2399:
2391:
2383:
2382:
2347:Carcinogenesis
2333:
2277:
2226:
2206:
2153:
2124:(5): 518–536.
2102:
2045:
2009:
1969:
1916:
1867:
1826:
1766:
1737:(8): 1626–34.
1714:
1655:
1604:
1550:
1499:
1480:(5): 207–212.
1464:
1445:(5): 639–646.
1425:
1357:
1355:
1354:
1284:
1263:(3): 338–345.
1243:
1206:(5067): 1273.
1184:
1149:
1110:
1071:(9): e105070.
1051:
994:
993:
991:
988:
979:
976:
957:cell membranes
949:reducing agent
852:
849:
799:
796:
793:
792:
789:
783:
782:
779:
773:
772:
769:
763:
762:
759:
753:
752:
749:
743:
742:
739:
733:
732:
729:
723:
722:
719:
713:
712:
709:
703:
702:
699:
693:
692:
689:
683:
682:
677:
664:yellow cypress
652:Monocotyledons
601:Butea frondosa
589:Acacia greggii
580:Eudicotyledons
575:
572:
528:
525:
524:
519:
497:
496:
492:standard state
489:
486:
485:
482:
476:
475:
472:
466:
465:
462:
456:
455:
451:
447:
443:
440:
435:
432:
431:
427:
426:
424:
423:
420:
412:
411:
410:
407:
406:
404:
403:
399:
396:
395:
393:
389:
386:
385:
377:
376:
375:
372:
371:
369:
368:
355:
353:
341:
338:
337:
335:
334:
326:
324:
318:
317:
315:
314:
306:
304:
296:
293:
292:
290:
289:
281:
279:
273:
272:
270:
269:
261:
259:
254:
251:
250:
240:
232:
231:
229:
228:
220:
218:
212:
211:
209:
208:
200:
198:
192:
191:
189:
188:
180:
178:
172:
171:
169:
168:
160:
158:
152:
151:
149:
148:
140:
138:
131:
128:
127:
125:
124:
116:
114:
109:
106:
105:
101:
100:
72:
68:
67:
59:
58:
52:
51:
48:
42:
41:
37:
36:
28:
27:
9:
6:
4:
3:
2:
3361:
3350:
3347:
3345:
3342:
3340:
3337:
3335:
3332:
3331:
3329:
3308:
3305:
3303:
3300:
3299:
3298:
3295:
3294:
3292:
3288:
3285:
3283:Semisynthetic
3281:
3271:
3267:
3263:
3262:Pongamoside A
3260:
3259:
3257:
3253:
3247:
3244:
3243:
3241:
3237:
3234:
3230:
3220:
3217:
3216:
3214:
3210:
3207:
3203:
3193:
3190:
3188:
3185:
3183:
3180:
3178:
3175:
3173:
3170:
3169:
3167:
3163:
3157:
3154:
3152:
3149:
3148:
3146:
3142:
3139:
3135:
3120:
3119:Xanthorhamnin
3117:
3115:
3111:
3108:
3105:
3101:
3098:
3095:
3092:
3089:
3086:
3083:
3079:
3076:
3073:
3070:
3069:
3067:
3063:
3057:
3054:
3052:
3049:
3046:
3042:
3039:
3038:
3036:
3032:
3029:
3025:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2974:
2971:
2969:
2966:
2964:
2961:
2959:
2956:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2916:
2914:
2911:
2909:
2906:
2904:
2901:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2871:
2870:
2868:
2864:
2861:
2858:
2854:
2835:
2832:
2829:
2826:
2823:
2820:
2817:
2814:
2811:
2808:
2806:
2803:
2801:
2798:
2795:
2792:
2789:
2786:
2783:
2780:
2777:
2773:
2770:
2767:
2763:
2760:
2758:
2755:
2752:
2749:
2748:
2746:
2742:
2736:
2733:
2731:
2728:
2726:
2723:
2722:
2720:
2716:
2713:
2711:
2706:
2699:
2696:
2694:
2691:
2689:
2686:
2683:
2679:
2676:
2675:
2673:
2671:
2666:
2659:
2656:
2653:
2650:
2648:
2645:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2604:
2602:
2599:
2597:
2594:
2592:
2589:
2587:
2584:
2581:
2578:
2575:
2574:Kaempferitrin
2572:
2569:
2566:
2563:
2560:
2559:
2557:
2555:
2550:
2544:
2541:
2539:
2536:
2535:
2533:
2531:
2526:
2523:
2519:
2513:
2510:
2508:
2505:
2503:
2502:Quercetagetin
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2464:
2462:
2458:
2455:
2453:
2449:
2438:
2435:
2434:
2432:
2428:
2425:
2421:
2412:
2407:
2405:
2400:
2398:
2393:
2392:
2389:
2378:
2374:
2369:
2364:
2360:
2356:
2352:
2348:
2344:
2337:
2329:
2325:
2320:
2315:
2311:
2307:
2304:(2): 151–62.
2303:
2299:
2295:
2288:
2286:
2284:
2282:
2273:
2269:
2264:
2259:
2254:
2249:
2245:
2241:
2237:
2230:
2216:
2210:
2202:
2198:
2193:
2188:
2183:
2178:
2174:
2170:
2169:
2164:
2157:
2149:
2145:
2140:
2135:
2131:
2127:
2123:
2119:
2118:
2113:
2106:
2098:
2094:
2089:
2084:
2080:
2076:
2072:
2068:
2064:
2060:
2056:
2049:
2041:
2037:
2033:
2029:
2025:
2021:
2020:Curr Med Chem
2013:
2005:
2001:
1997:
1993:
1989:
1985:
1978:
1976:
1974:
1965:
1961:
1956:
1951:
1946:
1941:
1937:
1933:
1932:
1927:
1920:
1912:
1908:
1903:
1898:
1894:
1890:
1886:
1882:
1878:
1871:
1863:
1859:
1854:
1849:
1845:
1841:
1837:
1830:
1822:
1818:
1813:
1808:
1804:
1800:
1795:
1790:
1786:
1782:
1778:
1770:
1762:
1758:
1753:
1748:
1744:
1740:
1736:
1732:
1728:
1721:
1719:
1710:
1706:
1702:
1698:
1693:
1688:
1684:
1680:
1676:
1672:
1671:
1666:
1659:
1651:
1647:
1642:
1637:
1632:
1627:
1623:
1619:
1615:
1608:
1600:
1596:
1591:
1586:
1581:
1576:
1572:
1568:
1564:
1557:
1555:
1546:
1542:
1537:
1532:
1527:
1522:
1518:
1514:
1510:
1503:
1495:
1491:
1487:
1483:
1479:
1475:
1468:
1460:
1456:
1452:
1448:
1444:
1440:
1432:
1430:
1421:
1417:
1412:
1407:
1403:
1399:
1395:
1388:
1386:
1384:
1382:
1380:
1378:
1376:
1374:
1372:
1370:
1368:
1366:
1364:
1362:
1351:
1347:
1343:
1342:
1339:
1335:
1330:
1325:
1320:
1315:
1311:
1307:
1304:(6): e21226.
1303:
1299:
1295:
1288:
1280:
1276:
1271:
1266:
1262:
1258:
1254:
1247:
1239:
1235:
1231:
1227:
1222:
1217:
1213:
1209:
1205:
1201:
1200:
1195:
1188:
1170:
1163:
1156:
1154:
1145:
1141:
1137:
1133:
1130:(1): 177–90.
1129:
1126:(in German).
1125:
1121:
1114:
1106:
1102:
1097:
1092:
1087:
1082:
1078:
1074:
1070:
1066:
1062:
1055:
1047:
1043:
1038:
1033:
1028:
1023:
1019:
1015:
1014:
1009:
1002:
1000:
995:
987:
983:
975:
973:
968:
966:
962:
958:
954:
950:
946:
941:
939:
935:
931:
927:
923:
922:interleukin 6
919:
915:
910:
908:
904:
900:
896:
891:
889:
885:
881:
877:
872:
870:
866:
861:
858:
855:Fisetin is a
848:
844:
840:
837:
833:
829:
825:
821:
817:
816:phenylalanine
813:
809:
806:, which is a
805:
802:Fisetin is a
790:
788:
785:
784:
780:
778:
775:
774:
770:
768:
765:
764:
760:
758:
755:
754:
750:
748:
745:
744:
740:
738:
735:
734:
730:
728:
725:
724:
720:
718:
715:
714:
710:
708:
705:
704:
700:
698:
695:
694:
690:
688:
685:
684:
678:
676:Plant source
675:
674:
671:
669:
665:
661:
657:
653:
649:
645:
641:
637:
633:
629:
625:
624:
619:
618:
613:
612:Anacardiaceae
609:
608:
603:
602:
597:
596:
591:
590:
585:
581:
571:
569:
565:
560:
558:
554:
550:
546:
542:
539:) is a plant
538:
534:
522:
515:
510:
493:
487:
483:
481:
480:Melting point
478:
477:
473:
471:
468:
467:
463:
461:
458:
457:
441:
438:
434:
433:
428:
419:
418:
415:
408:
394:
384:
383:
380:
373:
365:
361:
360:DTXSID4022317
357:
356:
354:
344:
340:
339:
332:
328:
327:
325:
323:
320:
319:
312:
308:
307:
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275:
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267:
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257:
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252:
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244:
241:
239:
237:ECHA InfoCard
234:
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206:
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107:
102:
98:Junger fustik
80:
69:
63:
57:
53:
47:
43:
38:
34:
29:
25:
20:
2963:Natsudaidain
2938:Isorhamnetin
2903:Centaureidin
2856:
2788:Isoquercetin
2466:
2350:
2346:
2336:
2301:
2297:
2243:
2239:
2229:
2218:. Retrieved
2209:
2175:(8): e2134.
2172:
2166:
2156:
2121:
2115:
2105:
2062:
2059:eBioMedicine
2058:
2048:
2023:
2019:
2012:
1987:
1983:
1935:
1931:Biomolecules
1929:
1919:
1884:
1880:
1870:
1846:(1): 15–21.
1843:
1839:
1829:
1784:
1781:eBioMedicine
1780:
1769:
1734:
1730:
1674:
1668:
1658:
1624:(534): 534.
1621:
1617:
1607:
1573:(222): 222.
1570:
1566:
1516:
1512:
1502:
1477:
1473:
1467:
1442:
1438:
1401:
1397:
1350:ScienceDaily
1349:
1301:
1297:
1287:
1260:
1256:
1246:
1203:
1197:
1187:
1176:. Retrieved
1169:the original
1127:
1123:
1113:
1068:
1064:
1054:
1017:
1011:
984:
981:
969:
942:
916:, including
911:
892:
873:
862:
854:
845:
841:
836:Transferases
801:
798:Biosynthesis
667:
644:strawberries
640:Rhus cotinus
639:
632:young fustic
631:
621:
615:
614:such as the
605:
599:
593:
587:
577:
561:
557:Josef Herzig
532:
531:
104:Identifiers
71:Other names
61:
3302:Monoxerutin
3151:Noricaritin
3018:Tamarixetin
2953:Kumatakenin
2948:Kaempferide
2923:Eupatolitin
2828:Spiraeoside
2794:Miquelianin
2776:galactoside
2766:arabinoside
2762:Guaijaverin
972:antimitotic
945:glutathione
930:deacylation
832:chalconoids
568:polyphenols
549:polyphenols
537:flavon-3-ol
474:1.688 g/mL
430:Properties
243:100.007.669
185:ChEMBL31574
165:CHEBI:42567
86:Superfustel
3328:Categories
3307:Troxerutin
3290:Glycosides
3255:Glycosides
3182:Phelloside
3165:Glycosides
3110:Patulitrin
3078:Centaurein
3027:Glycosides
3013:Syringetin
3008:Spinacetin
2988:Mearnsetin
2973:Pachypodol
2958:Laricitrin
2898:Brickellin
2834:Taxillusin
2810:Quercitrin
2782:Hyperoside
2751:Avicularin
2744:Glycosides
2698:Myricitrin
2568:Astragalin
2554:kaempferol
2530:herbacetin
2521:Conjugates
2487:Kaempferol
2482:Herbacetin
2477:Gossypetin
2220:2018-10-12
1938:(5): 174.
1519:(1): 242.
1178:2010-04-14
1020:(5): 137.
990:References
974:compound.
884:flavonoids
880:cell cycle
808:polyphenol
737:Lotus root
697:Strawberry
460:Molar mass
331:OO2ABO9578
256:IUPHAR/BPS
196:ChemSpider
132:3D model (
111:CAS Number
46:IUPAC name
3349:Catechols
3339:Flavonols
3239:Aglycones
3212:Aglycones
3172:Amurensin
3144:Aglycones
3094:Eupatolin
3041:Narcissin
2998:Rhamnetin
2993:Rhamnazin
2978:Patuletin
2933:Europetin
2928:Eupalitin
2913:Combretol
2893:Azaleatin
2888:Axillarin
2878:Annulatin
2866:Aglycones
2822:Reinutrin
2710:quercetin
2670:myricetin
2543:Rhodiosin
2538:Rhodionin
2512:Robinetin
2507:Quercetin
2497:Myricetin
2460:Aglycones
2452:Flavonols
2430:Aglycones
2079:2352-3964
2065:: 18–28.
1803:2352-3964
1787:: 18–28.
1144:197766725
1013:Nutrients
938:sirtuin 1
936:NF-ÎşB by
914:cytokines
907:quercetin
895:senolytic
869:apoptosis
804:flavonoid
757:Kiwifruit
717:Persimmon
660:Pinophyta
628:myricetin
559:in 1891.
547:group of
545:flavonoid
543:from the
535:(7,3′,4′-
88:Fisetholz
3246:Karanjin
2943:Jaceidin
2772:Heliosin
2718:Sulfates
2678:Betmidin
2658:Trifolin
2580:Juglanin
2472:Galangin
2423:Backbone
2377:19395653
2328:23121441
2272:32848804
2246:: 1225.
2201:32752135
2148:32686219
2097:30279143
2040:20939813
2004:24946050
1990:: 91–9.
1964:31064104
1911:23293889
1862:15213022
1821:30279143
1761:19897059
1709:25896400
1701:28417163
1692:11107671
1650:25346743
1599:23060891
1545:30165848
1494:12051572
1459:21185565
1420:10958819
1338:21738623
1298:PLOS ONE
1279:16176603
1230:21090477
1105:25184746
1065:PLOS ONE
1046:31109072
965:hydroxyl
828:chalcone
777:Cucumber
681:(ÎĽg /g)
654:such as
584:Fabaceae
541:flavonol
216:DrugBank
121:528-48-3
79:Cotinine
75:Cotinin
17:Fisetin
3192:Rutin S
3177:Icariin
3088:Eupalin
3072:Azalein
2983:Retusin
2918:Ermanin
2757:CTN-986
2641:Robinin
2562:Afzelin
2467:Fisetin
2368:2691139
2319:3689181
2263:7426493
2192:7464619
2168:Cancers
2139:7405395
2088:6197652
1955:6572624
1902:3985520
1812:6197652
1752:2886178
1641:4191440
1590:3460232
1536:6118002
1329:3124487
1306:Bibcode
1238:4262402
1208:Bibcode
1096:4153571
1073:Bibcode
1037:6562590
533:Fisetin
514:what is
512: (
470:Density
454:
311:5281614
298:PubChem
225:DB07795
205:4444933
3100:Jacein
3003:Santin
2968:Ombuin
2883:Ayanin
2375:
2365:
2326:
2316:
2270:
2260:
2199:
2189:
2146:
2136:
2095:
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2077:
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1277:
1236:
1228:
1199:Nature
1142:
1103:
1093:
1044:
1034:
961:lipids
924:, and
903:Bcl-xL
787:Tomato
747:Grapes
691:15000
656:onions
509:verify
506:
414:SMILES
286:C10041
176:ChEMBL
94:Fustet
92:Fustel
90:Fietin
40:Names
3065:other
2816:Rutin
2492:Morin
1705:S2CID
1234:S2CID
1172:(PDF)
1165:(PDF)
1140:S2CID
767:Peach
727:Onion
721:10.6
707:Apple
648:wines
553:ochre
379:InChI
156:ChEBI
134:JSmol
96:Viset
3268:and
2373:PMID
2324:PMID
2268:PMID
2197:PMID
2144:PMID
2093:PMID
2075:ISSN
2036:PMID
2000:PMID
1960:PMID
1907:PMID
1858:PMID
1817:PMID
1799:ISSN
1757:PMID
1735:1804
1697:PMID
1646:PMID
1595:PMID
1541:PMID
1490:PMID
1455:PMID
1443:1218
1416:PMID
1334:PMID
1275:PMID
1226:PMID
1101:PMID
1042:PMID
791:0.1
781:0.1
771:0.6
761:2.0
751:3.9
741:5.8
731:4.8
701:160
623:Rhus
592:and
562:The
322:UNII
277:KEGG
266:5182
2363:PMC
2355:doi
2314:PMC
2306:doi
2258:PMC
2248:doi
2187:PMC
2177:doi
2134:PMC
2126:doi
2122:288
2083:PMC
2067:doi
2028:doi
1992:doi
1988:559
1950:PMC
1940:doi
1897:PMC
1889:doi
1848:doi
1807:PMC
1789:doi
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1687:PMC
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1531:PMC
1521:doi
1482:doi
1447:doi
1406:doi
1402:130
1324:PMC
1314:doi
1265:doi
1216:doi
1204:212
1132:doi
1091:PMC
1081:doi
1032:PMC
1022:doi
711:26
670:).
348:EPA
301:CID
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